Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Y40 10403
2R:R:F69 6.2975407
3R:R:T73 5.1475408
4R:R:D95 8.1409
5R:R:V102 4.805417
6R:R:M103 6.9275417
7R:R:Y109 7.15416
8R:R:W115 8.85333618
9R:R:Q119 5.88414
10R:R:W125 6.97616
11R:R:W138 7.028516
12R:R:H139 7.07437
13R:R:C141 3.905417
14R:R:Y148 6.468508
15R:R:W149 10.28405
16R:R:Y157 10.7325428
17R:R:F176 5.6325405
18R:R:W187 10.565416
19R:R:C199 8.5875419
20R:R:Y208 7.7825458
21R:R:F217 9.922518
22R:R:Y218 7.1075416
23R:R:T221 3.99416
24R:R:L227 5.3625406
25R:R:Y228 4.9875409
26R:R:I231 2.5509
27R:R:F323 5.38333619
28R:R:W327 6.81167617
29R:R:F330 10.8175418
30R:R:F331 10.702517
31R:R:M337 5.5375414
32R:R:F351 9.9075414
33R:R:F354 6.6925406
34R:R:W356 7.5175816
35R:R:Y359 8.14667617
36R:R:I368 3468
37R:R:F376 7.25408
38L:L:?1 7.926471710
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:D352 R:R:Y40 12.90395.75NoYes043
2R:R:T107 R:R:W356 32.51833.64NoYes176
3R:R:M108 R:R:T107 30.75183.01NoNo057
4R:R:M108 R:R:V53 28.56674.56NoNo056
5R:R:V111 R:R:V53 26.71054.81NoNo066
6R:R:K49 R:R:V111 22.31956.07NoNo036
7R:R:I44 R:R:K49 20.11967.27NoNo013
8R:R:I44 R:R:W48 15.68971.17NoNo012
9R:R:S45 R:R:W48 11.2363.71NoNo062
10R:R:I59 R:R:W356 19.58153.52NoYes066
11L:L:?1 R:R:D352 12.91294.77YesNo004
12L:L:?1 R:R:Y359 47.84934.81YesYes107
13R:R:M103 R:R:Y359 11.92057.18YesYes177
14R:R:M103 R:R:T63 10.83846.02YesNo077
15L:L:?1 R:R:T134 67.6734.32YesNo107
16R:R:S177 R:R:T134 67.08124.8NoNo087
17R:R:A135 R:R:S177 66.22033.42NoNo088
18R:R:A135 R:R:W174 65.35357.78NoNo089
19R:R:T94 R:R:W174 63.60196.06NoNo089
20R:R:H139 R:R:T94 62.71716.85YesNo078
21R:R:H139 R:R:L91 60.02696.43YesNo079
22R:R:D95 R:R:L91 58.26935.43YesNo099
23R:R:D95 R:R:N67 54.550910.77YesNo099
24R:R:A92 R:R:N67 51.69934.69NoNo099
25R:R:F69 R:R:T73 10.29147.78YesYes078
26R:R:F376 R:R:T73 16.02756.49YesYes088
27R:R:F376 R:R:V70 47.80155.24YesNo089
28R:R:A92 R:R:V70 48.79393.39NoNo099
29R:R:F69 R:R:T370 10.16295.19YesNo077
30R:R:F376 R:R:T370 11.31975.19YesNo087
31R:R:F380 R:R:F69 16.03358.57NoYes077
32R:R:L80 R:R:N85 15.69579.61NoNo089
33R:R:D375 R:R:L80 17.86285.43NoNo068
34R:R:D375 R:R:N373 21.15388.08NoNo069
35R:R:F376 R:R:N373 22.289612.08YesNo089
36R:R:W149 R:R:Y157 29.762420.26YesYes058
37R:R:L145 R:R:W149 19.372311.39NoYes065
38R:R:L145 R:R:L227 21.00435.54NoYes066
39R:R:L223 R:R:L227 80.84294.15NoYes076
40R:R:C141 R:R:L223 82.35244.76YesNo077
41R:R:C141 R:R:P220 83.92773.77YesNo179
42R:R:I137 R:R:P220 1003.39NoNo189
43R:R:I137 R:R:W327 97.87184.7NoYes187
44R:R:C133 R:R:W327 54.81695.22NoYes067
45L:L:?1 R:R:C133 55.19954.65YesNo006
46R:R:W149 R:R:Y148 20.12554.82YesYes058
47R:R:L227 R:R:Y148 56.93627.03YesYes068
48R:R:F331 R:R:W327 64.87827.02YesYes177
49L:L:?1 R:R:F331 69.16167.85YesYes107
50R:R:F323 R:R:L140 10.09124.87YesNo198
51R:R:F217 R:R:F331 12.374821.43YesYes187
52R:R:N361 R:R:W327 11.7745.65NoYes097
53R:R:V102 R:R:W125 10.67114.9YesYes176
54L:L:?1 R:R:V201 16.82865.24YesNo106
55R:R:L126 R:R:V201 16.27265.96NoNo066
56R:R:W115 R:R:W125 15.95289.37YesYes186
57R:R:C199 R:R:L126 10.54854.76YesNo096
58R:R:L117 R:R:W115 10.99096.83NoYes068
59R:R:P220 R:R:W138 14.631613.51NoYes196
60R:R:F176 R:R:W138 10.75778.02YesYes056
61R:R:I231 R:R:Y148 31.91152.42YesYes098
62R:R:K160 R:R:Y157 13.17592.39NoYes058
63L:L:?1 R:R:S212 12.01913.52YesNo007
64R:R:S212 R:R:Y208 10.97297.63NoYes078
65R:R:I231 R:R:L316 16.95112.85YesNo098
66R:R:L316 R:R:Y228 15.50745.86NoYes089
67R:R:F386 R:R:I384 11.60963.77NoNo046
68R:R:F380 R:R:I384 13.9717.54NoNo076
69R:R:I59 R:R:L360 15.15172.85NoNo064
70R:R:I364 R:R:L360 12.92785.71NoNo064
71R:R:F354 R:R:I333 11.25395.02YesNo064
72R:R:F351 R:R:I333 15.81537.54YesNo044
73L:L:?1 R:R:F351 13.017519.27YesYes104
74L:L:?1 R:R:T355 23.16846.91YesNo106
75R:R:T355 R:R:W356 31.32573.64NoYes166
76R:R:W356 R:R:Y359 22.74716.4YesYes167
77R:R:F330 R:R:F331 11.750110.72YesYes187
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D352 R:R:Y40 5.75 0 No Yes 4 3 1 2
R:R:D129 R:R:V102 7.3 1 No Yes 8 7 1 2
R:R:V102 R:R:Y359 3.79 1 Yes Yes 7 7 2 1
R:R:M103 R:R:W356 6.98 1 Yes Yes 7 6 2 2
R:R:M103 R:R:Y359 7.18 1 Yes Yes 7 7 2 1
R:R:S106 R:R:W356 4.94 1 No Yes 6 6 2 2
R:R:S106 R:R:Y359 6.36 1 No Yes 6 7 2 1
R:R:D352 R:R:T110 7.23 0 No No 4 5 1 2
R:R:T110 R:R:W356 8.49 0 No Yes 5 6 2 2
R:R:L126 R:R:V201 5.96 0 No No 6 6 2 1
R:R:D129 R:R:Y359 10.34 1 No Yes 8 7 1 1
L:L:?1 R:R:D129 15.11 1 Yes No 0 8 0 1
R:R:I130 R:R:S181 4.64 1 No No 6 7 1 2
R:R:I130 R:R:V201 4.61 1 No No 6 6 1 1
L:L:?1 R:R:I130 9.2 1 Yes No 0 6 0 1
R:R:C133 R:R:W327 5.22 0 No Yes 6 7 1 2
L:L:?1 R:R:C133 4.65 1 Yes No 0 6 0 1
R:R:S177 R:R:T134 4.8 0 No No 8 7 2 1
R:R:A216 R:R:T134 5.03 1 No No 7 7 1 1
L:L:?1 R:R:T134 4.32 1 Yes No 0 7 0 1
R:R:E198 R:R:V200 8.56 0 No No 4 3 2 1
L:L:?1 R:R:V200 11.35 1 Yes No 0 3 0 1
L:L:?1 R:R:V201 5.24 1 Yes No 0 6 0 1
R:R:S212 R:R:Y208 7.63 0 No Yes 7 8 1 2
L:L:?1 R:R:S212 3.52 1 Yes No 0 7 0 1
R:R:F331 R:R:T213 6.49 1 Yes No 7 6 1 2
L:L:?1 R:R:A216 3.69 1 Yes No 0 7 0 1
R:R:F217 R:R:F331 21.43 1 Yes Yes 8 7 2 1
R:R:F331 R:R:W327 7.02 1 Yes Yes 7 7 1 2
R:R:F330 R:R:F331 10.72 1 Yes Yes 8 7 1 1
R:R:F330 R:R:F351 5.36 1 Yes Yes 8 4 1 1
R:R:F330 R:R:T355 6.49 1 Yes No 8 6 1 1
L:L:?1 R:R:F330 20.7 1 Yes Yes 0 8 0 1
L:L:?1 R:R:F331 7.85 1 Yes Yes 0 7 0 1
R:R:F351 R:R:I333 7.54 1 Yes No 4 4 1 2
L:L:?1 R:R:S334 3.52 1 Yes No 0 6 0 1
R:R:M337 R:R:P338 6.71 1 Yes No 4 5 1 2
R:R:F351 R:R:M337 7.46 1 Yes Yes 4 4 1 1
L:L:?1 R:R:M337 4.97 1 Yes Yes 0 4 0 1
L:L:?1 R:R:L348 4.87 1 Yes No 0 2 0 1
L:L:?1 R:R:F351 19.27 1 Yes Yes 0 4 0 1
L:L:?1 R:R:D352 4.77 1 Yes No 0 4 0 1
R:R:T355 R:R:W356 3.64 1 No Yes 6 6 1 2
L:L:?1 R:R:T355 6.91 1 Yes No 0 6 0 1
R:R:W356 R:R:Y359 16.4 1 Yes Yes 6 7 2 1
L:L:?1 R:R:Y359 4.81 1 Yes Yes 0 7 0 1
R:R:M337 R:R:T203 3.01 1 Yes No 4 7 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
88.24Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
84.21Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
82.35Single6MXTSalmeterol6MXT-β2-Salmeterol
77.78Single6IBLArformoterol6IBL-β1-Arformoterol
76.47Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
76.47Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
72.22Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
72.22Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
72.22Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
72.22Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
72.22Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
72.22Single8JJ8Formoterol8JJ8-β2-Formoterol
72.22Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
70.59Single7XKAEpinephrine7XKA-β2-Epinephrine
70.59Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
70.59Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
68.42Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
68.42Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
68.42Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
68.18Single7C61Ergotamine7C61-5-HT1B-Ergotamine
66.67Single3P0GBI1671073P0G-β2-BI167107
66.67Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
66.67Single4RWADIPP-NH24RWA-δ-DIPP-NH2
66.67Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
66.67Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
66.67Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
66.67Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
64.71Single6PS1Timolol6PS1-β2-Timolol
64.71Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
64.71Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
64.71Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
64.71Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
64.71Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
64.71Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
64.71Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.71Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.71Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.71Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.71Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.71Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.71Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.71Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.71Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.71Single8GGJEpinephrine8GGJ-β2-Epinephrine
64.71Single8GGNEpinephrine8GGN-β2-Epinephrine
64.71Single8GGOEpinephrine8GGO-β2-Epinephrine
64.71Single8GGUEpinephrine8GGU-β2-Epinephrine
64.71Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.71Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.71Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.71Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
64.71Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
64.71Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
64.71Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
63.64Single5WF5UK-4320975WF5-A2A-UK-432097
63.16Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
63.16Single4AMIBucindolol4AMI-β1-Bucindolol
63.16Single4LDEBI1671074LDE-β2-BI167107
63.16Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
63.16Single8JJLOlodaterol8JJL-β2-Olodaterol
61.11Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
61.11Single6E67BI1671076E67-β2-BI167107-Gs (fused)
61.11Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
61.11Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
61.11Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
61.11Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
61.11Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
61.11Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
61.11Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
61.11Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
61.11Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
61.11Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
61.11Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
61.11Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
60.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
60.00Single6H7LDobutamine6H7L-β1-Dobutamine
60.00Single7EZCUKA7EZC-A2A-UKA
60.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
59.09Single3QAKUK-4320973QAK-A2A-UK-432097
58.82Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
58.82Single6PS4ICI 118-5516PS4-β2-ICI 118-551
58.82Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
58.82Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
58.82Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
58.82Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
58.82Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
58.82Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
58.82Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
58.82Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
58.82Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
58.82Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
58.82Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
58.82Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
58.82Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.82Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.82Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.82Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.82Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.82Single8GGIEpinephrine8GGI-β2-Epinephrine
58.82Single8GGKEpinephrine8GGK-β2-Epinephrine
58.82Single8GGMEpinephrine8GGM-β2-Epinephrine
58.82Single8GGPEpinephrine8GGP-β2-Epinephrine
58.82Single8GGQEpinephrine8GGQ-β2-Epinephrine
58.82Single8GGTEpinephrine8GGT-β2-Epinephrine
58.82Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.82Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.82Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.82Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.82Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.82Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
58.33Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
57.89Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
57.89Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
57.89Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
57.89Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
57.89Single6H7JIsoprenaline6H7J-β1-Isoprenaline
57.89Single6WGTLSD6WGT-5-HT2A-LSD
57.89Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
57.89Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
57.89Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
57.89Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
57.89Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
57.89Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
57.14Single3NY9PubChem 9131033NY9-β2-PubChem 913103
57.14Single5WF6UK-4320975WF6-A2A-UK-432097
57.14Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
56.52Consensusangiotensin_onOrthosteric Ligandat1_on
56.52Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
55.56Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
55.56Single2Y02Carmoterol2Y02-β1-Carmoterol
55.56Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
55.56Single3NY8ICI 118-5513NY8-β2-ICI 118-551
55.56Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
55.56Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
55.56Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
55.56Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
55.56Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
55.56Single6H7MSalbutamol6H7M-β1-Salbutamol
55.56Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
55.56Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
55.56Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
55.56Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
55.56Single7BU7BI1671077BU7-β1-BI167107
55.56Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
55.56Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
55.56Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
55.56Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
55.56Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
55.56Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
55.56Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
55.56Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
55.56Single8JJOAlprenolol8JJO-β2-Alprenolol
55.56Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
55.56Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
55.56Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
55.56Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
55.56Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
55.56Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
55.00Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
55.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
55.00Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
55.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
54.55Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
54.55Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
54.55Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
54.55Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
54.17Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
54.17Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
52.94Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
52.94Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
52.94Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
52.94Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
52.94Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
52.94Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
52.94Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
52.94Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
52.94Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
52.94Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
52.94Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
52.94Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
52.94Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
52.94Single8GGVEpinephrine8GGV-β2-Epinephrine
52.94Single8GGWEpinephrine8GGW-β2-Epinephrine
52.94Single8GGXEpinephrine8GGX-β2-Epinephrine
52.94Single8GH0Epinephrine8GH0-β2-Epinephrine
52.94Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
52.94Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
52.94Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
52.94Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
52.94Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
52.94Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
52.94Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
52.94Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
52.94Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
52.63Single2Y03Isoprenaline2Y03-β1-Isoprenaline
52.63Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
52.63Single5C1MBU725C1M-μ-BU72
52.63Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
52.63Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
52.63Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
52.63Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
52.63Single7WC6LSD7WC6-5-HT2A-LSD
52.63Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
52.63Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
52.63Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
52.63Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
52.63Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
52.63Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
52.63Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
52.38Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
52.38Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
52.38Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
52.38Single7UM4AS26747237UM4-5-HT5A-AS2674723
52.38Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
52.38Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
52.38Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
52.38Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
52.38Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
52.38Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
52.38Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
52.38Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
52.38Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
52.17Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
51.85Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
50.00Single2YDVNECA2YDV-A2A-NECA
50.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
50.00Single4U15Tiotropium4U15-M3-Tiotropium
50.00Single4UG2CGS216804UG2-A2A-CGS21680
50.00Single4UHRCGS216804UHR-A2A-CGS21680
50.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
50.00Single5G53NECA5G53-A2A-NECA-Gs
50.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
50.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
50.00Single6OL9Tiotropium6OL9-M5-Tiotropium
50.00Single6PT3DPI-2876PT3-δ-DPI-287
50.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
50.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
50.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
50.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
50.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
50.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
50.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Single7XN9L-054,5227XN9-SST2-L-054,522
50.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
50.00Single8E0GBU728E0G-μ-BU72
50.00Single8GGLEpinephrine8GGL-β2-Epinephrine
50.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
50.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
50.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
50.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8X5YAstemizole8X5Y-H1-Astemizole
50.00Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
50.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
50.00Consensus5ht5_offOrthosteric Ligand5ht5a_off
50.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
50.00Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Consensusa2_onOrthosteric Liganda2a_on a2b_on
50.00Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
50.00Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
50.00Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
50.00Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
50.00Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
50.00Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
50.00Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
50.00Consensushistamine_offOrthosteric Ligandh1_off
50.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
48.15Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
47.83Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
47.83Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
47.83Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
47.83Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
47.62Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
47.62Single5CXVTiotropium5CXV-M1-Tiotropium
47.62Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
47.62Single6A93Risperidone6A93-5-HT2A-Risperidone
47.62Single6CM4Risperidone6CM4-D2-Risperidone
47.62Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
47.62Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
47.62Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
47.62Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.62Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
47.62Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
47.62Single7YITNalfurafine7YIT-κ-Nalfurafine
47.62Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
47.62Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.62Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
47.62Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
47.62Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
47.62Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
47.62Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
47.37Single2Y01Dobutamine2Y01-β1-Dobutamine
47.37Single2Y04Salbutamol2Y04-β1-Salbutamol
47.37Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
47.37Single4EJ4Naltrindole4EJ4-δ-Naltrindole
47.37Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
47.37Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
47.37Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
47.37Single7WC7Lisuride7WC7-5-HT2A-Lisuride
47.37Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
47.37Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
47.37Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
47.37Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
47.37Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
47.37Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
47.37Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
47.37Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
47.37Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
47.37Single8X64Desloratadine8X64-H1-Desloratadine
47.37Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
47.37Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
47.37Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
47.37Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
47.37Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
47.37Consensustar_onOrthosteric Ligandta1_on
47.06Single3PBLEticlopride3PBL-D3-Eticlopride
47.06Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
47.06Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
47.06Single7SRQLSD7SRQ-5-HT2B-LSD
47.06Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
47.06Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
47.06Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
47.06Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
47.06Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
47.06Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
47.06Single8GGSEpinephrine8GGS-β2-Epinephrine
47.06Single8GGYEpinephrine8GGY-β2-Epinephrine
47.06Single8GH1Epinephrine8GH1-β2-Epinephrine
47.06Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
47.06Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
47.06Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
47.06Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
47.06Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
47.06Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
46.43Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
46.15Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
46.15Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
46.15Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
45.83Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
45.83Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
45.83Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
45.45Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
45.45Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
45.00Single2Y00Dobutamine2Y00-β1-Dobutamine
45.00Single5TVNLSD5TVN-5-HT2B-LSD
45.00Single5WIUNemonapride5WIU-D4-Nemonapride
45.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
45.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
45.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
45.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
45.00Single6PS6Timolol6PS6-β2-Timolol
45.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
45.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
45.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
45.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
45.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
45.00Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
45.00Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
45.00Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
45.00Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
45.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
45.00Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
45.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.83Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
44.44Single6KUXRS-799486KUX-α2a-RS-79948
44.44Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
44.44Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
44.44Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
44.44Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
44.44Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
44.44Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
44.44Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
44.44Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
44.44Single8GNGIstradefylline8GNG-A2A-Istradefylline
44.44Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
44.44Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
44.44Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
44.44Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
44.44Consensusalpha1_onOrthosteric Ligandalpha1a_on
44.44Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
44.44Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
44.44Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
44.44Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
44.44Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
44.44Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
44.00Single6PT2KGCHM076PT2-δ-KGCHM07
44.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
44.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
44.00Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
43.48Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
43.48Single7SK9CCX6627SK9-ACKR3-CCX662
43.48Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
43.48Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
43.48Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
42.86Single5V54Methiothepin5V54-5-HT1B-Methiothepin
42.86Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
42.86Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
42.86Single6J21Aprepitant6J21-NK1-Aprepitant
42.86Single6TQ7SB-3348676TQ7-OX1-SB-334867
42.86Single7B6WCyclazosin7B6W-α1b-Cyclazosin
42.86Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
42.86Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
42.86Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
42.86Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
42.86Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
42.86Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
42.86Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
42.86Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
42.86Consensus5ht1_offOrthosteric Ligand5ht1b_off
42.86Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
42.86Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
42.86Consensusendothelin_onOrthosteric Ligandetb_on eta_on
42.86Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
42.86Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
42.86Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
42.86Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
42.86Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
42.31Single6JODAngiotensin II6JOD-AT2-Angiotensin II
42.31Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
42.31Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
42.31Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
42.11Single3REYPubChem 56973REY-A2A-PubChem 5697
42.11Single3RZECidoxepin3RZE-H1-Cidoxepin
42.11Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
42.11Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
42.11Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
42.11Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
42.11Single6A94Zotepine6A94-5-HT2A-Zotepine
42.11Single6DS0Ly2660976DS0-5-HT2B-Ly266097
42.11Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
42.11Single6TPGEMPA6TPG-OX2-EMPA
42.11Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
42.11Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
42.11Single7AROLUF58337ARO-A2A-LUF5833-Na
42.11Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
42.11Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
42.11Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
42.11Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
42.11Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
42.11Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.11Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
42.11Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
42.11Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
42.11Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.11Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
42.11Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
41.67Single7F8XNN90567F8X-CCKA-NN9056
41.67Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
41.67Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
41.67Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
41.67Consensussst_onOrthosteric Ligandsst2_on sst4_on
41.38Single6IGLIRL16206IGL-ETB-IRL1620
41.38Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
41.38Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.38Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
41.18Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
41.18Single8GGREpinephrine8GGR-β2-Epinephrine
41.18Single8GGZEpinephrine8GGZ-β2-Epinephrine
41.18Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.91Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.91Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
40.91Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
40.91Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
40.91Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
40.91Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
40.91Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
40.91Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
40.91Consensusdp_offOrthosteric Liganddp2_off
40.91Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
40.91Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
40.91Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
40.74Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
40.74Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
40.74Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
40.74Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
40.74Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
40.74Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.74Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
40.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
40.00Single4MQSIperoxo4MQS-M2-Iperoxo
40.00Single4U14Tiotropium4U14-M3-Tiotropium
40.00Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
40.00Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
40.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
40.00Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
40.00Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
40.00Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
40.00Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
40.00Single6D27CAY104716D27-DP2-CAY10471
40.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
40.00Single6HLOAprepitant6HLO-NK1-Aprepitant
40.00Single6LPJZM2413856LPJ-A2A-ZM241385-Na
40.00Single6LPKZM2413856LPK-A2A-ZM241385-Na
40.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
40.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
40.00Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
40.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
40.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
40.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
40.00Single7UL4Alvimopan7UL4-μ-Alvimopan
40.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
40.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
40.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
40.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
40.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
40.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
40.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
40.00Single8X63Mepyramine8X63-H1-Mepyramine
40.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
40.00Consensusadenosine_onOrthosteric Liganda1_on a2_on
40.00Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
40.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
40.00Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
40.00Consensushistamine_onOrthosteric Ligandh1_on h4_on
40.00Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
40.00Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
40.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
40.00Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
40.00Consensusnucleotide_onOrthosteric Ligandadenosine_on
39.29Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
39.29Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
39.29Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
39.13Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
39.13Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
39.13Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
39.13Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
39.13Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
39.13Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
39.13Consensusendothelin_offOrthosteric Ligandetb_off
39.13Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
39.13Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
39.13Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
39.13Consensusorexin_onOrthosteric Ligandox2_on
38.89Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
38.89Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
38.89Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
38.89Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
38.89Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
38.89Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
38.89Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
38.89Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
38.89Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
38.89Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
38.71Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
38.46Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
38.46Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
38.46Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
38.10Single5IUAQ274563485IUA-A2A-Q27456348-Na
38.10Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
38.10Single5NM2ZM2413855NM2-A2A-ZM241385-Na
38.10Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
38.10Single5WQCEMPA5WQC-OX2-EMPA
38.10Single6D26Fevipiprant6D26-DP2-Fevipiprant
38.10Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
38.10Single6LPLZM2413856LPL-A2A-ZM241385-Na
38.10Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
38.10Single6S0QZM2413856S0Q-A2A-ZM241385
38.10Single6WQAZM2413856WQA-A2A-ZM241385-Na
38.10Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
38.10Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
38.10Single7RM5ZM2413857RM5-A2A-ZM241385-Na
38.10Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
38.10Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
38.10Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
38.10Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
38.10Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
38.10Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.10Single8FYNZM2413858FYN-A2A-ZM241385-Na
38.10Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
38.10Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
38.10Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
38.10Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
38.10Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
37.93Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.93Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
37.50Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
37.50Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
37.50Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
37.50Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
37.50Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
37.50Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
37.50Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
37.50Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
37.50Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
37.50Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
37.50Consensuslpl_onOrthosteric Ligands1p_on lpa_on
37.50Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
37.04Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
37.04Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
37.04Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.04Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
37.04Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
36.84Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
36.84Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
36.84Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
36.84Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
36.84Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
36.84Single6AKXA4R6AKX-CCR5-A4R
36.84Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
36.84Single6TODEMPA6TOD-OX1-EMPA-Na
36.84Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
36.84Single7F8ULintitript7F8U-CCKA-Lintitript
36.84Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.84Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
36.84Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
36.84Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
36.84Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
36.84Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
36.84Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
36.84Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
36.84Single8IWESpermidine8IWE-TAAR9-Spermidine
36.84Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.67Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
36.36Single5X93K-87945X93-ETB-K-8794
36.36Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
36.36Single6J20Aprepitant6J20-NK1-Aprepitant
36.36Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
36.36Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
36.36Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
36.36Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
36.36Single7PX4PSB-21137PX4-A2A-PSB-2113
36.36Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
36.36Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
36.36Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
36.36Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
36.36Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
36.36Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.36Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
36.36Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
36.36Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
36.36Consensusadenosine_offOrthosteric Liganda1_off a2_off
36.36Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
36.36Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
36.36Consensuscck_onOrthosteric Ligandccka_on cckb_on
36.36Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
36.36Consensuschemerin_onOrthosteric Ligandcml1_on
36.36Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
36.36Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
36.36Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
36.36Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.36Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
36.36Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
36.36Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
36.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
36.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
36.00Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
36.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
36.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
36.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
36.00Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
36.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
36.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
35.71Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
35.71Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
35.48Single6IGKEndothelin-36IGK-ETB-Endothelin-3
35.29Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Single2YDOAdenosine2YDO-A2A-Adenosine
35.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
35.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
35.00Single5IU4ZM2413855IU4-A2A-ZM241385-Na
35.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
35.00Single5K2BZM2413855K2B-A2A-ZM241385-Na
35.00Single5K2CZM2413855K2C-A2A-ZM241385-Na
35.00Single5NLXZM2413855NLX-A2A-ZM241385-Na
35.00Single5NM4ZM2413855NM4-A2A-ZM241385-Na
35.00Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
35.00Single6AQFZM2413856AQF-A2A-ZM241385
35.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
35.00Single6MH8ZM2413856MH8-A2A-ZM241385
35.00Single6TPNHTL66416TPN-OX2-HTL6641
35.00Single6VI4JDTic6VI4-κ-JDTic
35.00Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
35.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
35.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
35.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.00Single7T32ZM2413857T32-A2A-ZM241385
35.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
35.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
35.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
35.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
35.00Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
35.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
35.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
35.00Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
35.00Consensushca_onOrthosteric Ligandhca2_on hca3_on
35.00Consensushcar_onOrthosteric Ligandhca_on
35.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
35.00Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
35.00Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
34.78Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
34.78Single6HLPNetupitant6HLP-NK1-Netupitant
34.78Single6ZG4HTL00099366ZG4-M1-HTL0009936
34.78Single7DFPSpiperone7DFP-D2-Spiperone
34.78Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
34.78Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.78Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
34.78Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
34.78Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
34.78Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
34.78Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
34.78Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
34.78Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
34.78Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
34.78Single8JWZAB9288JWZ-A2A-AB928-Na
34.78Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
34.78Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
34.78Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
34.78Consensusgs_steroidOrthosteric Ligandgs_bileacid
34.78Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
34.78Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
34.78Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
34.62Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
34.62Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
34.62Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
34.62Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
34.62Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
34.62Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
34.48Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
34.48Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
34.38Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
33.33Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
33.33Single3EMLZM2413853EML-A2A-ZM241385
33.33Single3OE0CVX153OE0-CXCR4-CVX15
33.33Single3UZAGTPL92363UZA-A2A-GTPL9236
33.33Single4DAJTiotropium4DAJ-M3-Tiotropium
33.33Single4EIYZM2413854EIY-A2A-ZM241385-Na
33.33Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
33.33Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
33.33Single5DSGTiotropium5DSG-M4-Tiotropium
33.33Single5IU8Q274563475IU8-A2A-Q27456347-Na
33.33Single5K2AZM2413855K2A-A2A-ZM241385-Na
33.33Single5OLGZM2413855OLG-A2A-ZM241385-Na
33.33Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
33.33Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
33.33Single5UENDU1725UEN-A1-DU172
33.33Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
33.33Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
33.33Single5VRAZM2413855VRA-A2A-ZM241385-Na
33.33Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
33.33Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
33.33Single6S0LZM2413856S0L-A2A-ZM241385
33.33Single6TOTLemborexant6TOT-OX1-Lemborexant
33.33Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
33.33Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
33.33Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
33.33Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
33.33Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
33.33Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
33.33Single7PYRPSB-21157PYR-A2A-PSB-2115
33.33Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
33.33Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
33.33Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
33.33Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
33.33Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
33.33Single7WC5Psilocin7WC5-5-HT2A-Psilocin
33.33Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
33.33Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
33.33Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
33.33Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
33.33Single8CU6LJ-45178CU6-A2A-LJ-4517
33.33Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
33.33Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
33.33Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
33.33Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
33.33Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
33.33Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
33.33Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensusa2_offOrthosteric Liganda2a_off
33.33Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
33.33Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
33.33Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
33.33Consensusblt_onOrthosteric Ligandblt1_on
33.33Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
33.33Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Consensusgi_hcarOrthosteric Ligandgi_hca
33.33Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
33.33Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
33.33Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
33.33Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Consensusleuko_onOrthosteric Ligandblt_on
33.33Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
33.33Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
33.33Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
33.33Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
33.33Consensussteroid_onOrthosteric Ligandbileacid_on
33.33Consensustachykinin_offOrthosteric Ligandnk1_off
32.35Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
32.26Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
32.26Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
32.26Single8IY6Endothelin-18IY6-ETB-Endothelin-1
32.14Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
32.14Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
32.14Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
32.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
32.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
32.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
32.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
32.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
32.00Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
32.00Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
32.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
32.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
31.82Single4NTJAZD12834NTJ-P2Y12-AZD1283
31.82Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
31.82Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
31.82Single5N2SPSB365N2S-A1-PSB36
31.82Single5XPRBosentan5XPR-ETB-Bosentan
31.82Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
31.82Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
31.82Single6LUQHaloperidol6LUQ-D2-Haloperidol
31.82Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
31.82Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
31.82Single6TP6Filorexant6TP6-OX1-Filorexant
31.82Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
31.82Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
31.82Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.82Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.82Single8EA0Iperoxo8EA0-M3-Iperoxo
31.82Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
31.82Single8GNEKW-63568GNE-A2A-KW-6356-Na
31.82Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
31.82Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
31.82Single8QOTNanobody E8QOT-μ-Nanobody E
31.82Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.82Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
31.82Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.82Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
31.58Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
31.58Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
31.58Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
31.58Single6HLLCP999946HLL-NK1-CP99994
31.58Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
31.58Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
31.58Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
31.58Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
31.58Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
31.58Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
31.25Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
31.25Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
31.03Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.03Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.03Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
31.03Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
31.03Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
30.77Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
30.77Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
30.77Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
30.43Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
30.43Single4DJHJDTic4DJH-κ-JDTic
30.43Single6E59L-7607356E59-NK1-L-760735
30.43Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
30.43Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
30.43Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
30.43Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
30.43Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
30.43Single7TUYGSK682753A7TUY-GPR183-GSK682753A
30.43Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
30.43Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
30.43Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
30.43Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
30.43Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
30.43Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
30.43Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
30.43Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
30.43Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
30.43Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.43Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
30.43Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
30.43Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
30.43Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
30.43Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
30.43Consensuslpa_offOrthosteric Ligandlpa1_off
30.43Consensuslpa_onOrthosteric Ligandlpa1_on
30.43Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
30.43Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
30.43Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
30.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
30.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
30.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
30.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
30.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
30.00Single3PWHZM2413853PWH-A2A-ZM241385
30.00Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
30.00Single5DHHSB-6121115DHH-NOP-SB-612111
30.00Single5K2DZM2413855K2D-A2A-ZM241385
30.00Single5WS3EMPA5WS3-OX2-EMPA
30.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
30.00Single6B73PubChem 1319551386B73-κ-PubChem 131955138
30.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
30.00Single6JZHZM2413856JZH-A2A-ZM241385-Na
30.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
30.00Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
30.00Single6PS7ZM2413856PS7-A2A-ZM241385-Na
30.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
30.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
30.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
30.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
30.00Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
30.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
30.00Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
30.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
30.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
30.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
30.00Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
30.00Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
30.00Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
30.00Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
30.00Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Consensusgt_class-aOrthosteric Ligandgt_opsin
30.00Consensusgt_opsinOrthosteric Ligandgt_sensory
30.00Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
30.00Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
30.00Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
30.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
30.00Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
30.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
29.63Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
29.63Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
29.63Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
29.41Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
29.17Single4N4WSANT-14N4W-SMO-SANT-1
29.17Single6OS2TRV0266OS2-AT1-TRV026
29.17Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
29.17Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
29.17Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
29.17Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
29.17Single7K15MKD0467K15-BLT1-MKD046-Na
29.17Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
29.17Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
29.17Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
29.17Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
29.17Single8WU1KCA8WU1-CB1-KCA-Arrestin1
29.17Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
29.17Consensusblt_offOrthosteric Ligandblt1_off
29.17Consensusgi_class-fOther Ligandgi_frizzled
29.17Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
29.17Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
29.03Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
29.03Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
29.03Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
29.03Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
28.57Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
28.57Single5IU7Q274563465IU7-A2A-Q27456346-Na
28.57Single5JTBZM2413855JTB-A2A-ZM241385
28.57Single5UVIZM2413855UVI-A2A-ZM241385
28.57Single6IQLL7458706IQL-D4-L745870
28.57Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
28.57Single6V9SGTPL114036V9S-OX1-GTPL11403
28.57Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
28.57Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
28.57Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
28.57Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
28.57Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
28.57Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
28.57Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
28.57Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
28.57Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
28.57Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
28.57Single8K5CAcipimox8K5C-HCA2-Acipimox
28.57Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
28.57Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
28.57Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
28.57Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
28.57Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
28.57Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
28.57Consensussensory_offOrthosteric Ligandopsin_off
28.12Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
28.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
28.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
28.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
28.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
28.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
28.00Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
28.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
28.00Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
28.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
27.78Single3RFMCaffeine3RFM-A2A-Caffeine
27.78Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
27.78Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
27.78Single8A2OTheophylline8A2O-A2A-Theophylline-Na
27.78Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
27.78Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
27.78Consensussensory_onOrthosteric Ligandopsin_on
27.59Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
27.59Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
27.59Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
27.59Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
27.59Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
27.27Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
27.27Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
27.27Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
27.27Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
27.27Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
27.27Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
27.27Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
27.27Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
27.27Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
27.27Single8K5DGSK2560738K5D-HCA2-GSK256073
27.27Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
27.27Consensuscck_offOrthosteric Ligandccka_off
27.27Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
27.27Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
27.27Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
27.27Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
27.27Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
26.92Single5ZTYAM102575ZTY-CB2-AM10257
26.92Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
26.92Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
26.92Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
26.92Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
26.92Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
26.92Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
26.92Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
26.92Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
26.92Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
26.67Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
26.67Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.47Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
26.32Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
26.32Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
26.32Single6ME5Agomelatine6ME5-MT1-Agomelatine
26.32Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
26.32Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
26.32Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
26.32Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
26.32Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
26.09Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
26.09Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
26.09Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
26.09Single7SINNPS-21437SIN-CaS-NPS-2143
26.09Single7SINNPS-21437SIN-CaS-NPS-2143
26.09Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
26.09Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.09Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.09Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.09Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
26.09Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
26.09Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
26.09Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
26.09Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
25.93Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
25.93Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.93Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
25.93Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.81Single4XT3Fractalkine4XT3-US28-Fractalkine
25.81Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
25.81Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
25.81Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
25.81Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
25.71Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
25.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
25.00Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
25.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
25.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
25.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
25.00Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
25.00Single5XR8AM8415XR8-CB1-AM841
25.00Single5XRAAM115425XRA-CB1-AM11542
25.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
25.00Single6OS1TRV0266OS1-AT1-TRV026
25.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
25.00Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
25.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
25.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
25.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
25.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
25.00Single7EPENAM5637EPE-mGlu-NAM563
25.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
25.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
25.00Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
25.00Single7SK5CXCL127SK5-ACKR3-CXCL12
25.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
25.00Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
25.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single7W41PD1762527W41-BB2-PD176252
25.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
25.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
25.00Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
25.00Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
25.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
25.00Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
25.00Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
25.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
25.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
25.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
25.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
25.00Single8K5BNiacin8K5B-HCA2-Niacin
25.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
25.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
25.00Consensusbombesin_offOrthosteric Ligandbb2_off
25.00Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
25.00Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
25.00Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
25.00Consensussst_offOrthosteric Ligandsst2_off
24.24Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
24.14Single6W25SHU91196W25-MC4-SHU9119-Ca
24.14Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
24.14Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
24.14Single7XNACYN1548067XNA-SST2-CYN154806
24.14Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
24.14Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
24.14Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
24.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
24.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
24.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
24.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
24.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
24.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
24.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
24.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
24.00Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
24.00Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
24.00Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
24.00Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
24.00Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
24.00Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
23.81Single4S0VSuvorexant4S0V-OX2-Suvorexant
23.81Single6TPJSuvorexant6TPJ-OX2-Suvorexant
23.81Single7BR3Elagolix7BR3-GnRH1-Elagolix
23.81Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
23.81Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
23.81Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
23.81Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
23.81Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
23.81Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
23.81Single7XRRLemborexant7XRR-OX2-Lemborexant
23.81Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
23.81Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
23.81Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
23.81Single8IHKAcifran8IHK-HCA3-Acifran
23.81Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
23.81Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
23.81Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
23.81Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
23.81Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
23.81Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
23.53Single5MZPCaffeine5MZP-A2A-Caffeine-Na
23.33Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
23.33Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
23.33Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
23.33Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
23.33Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
23.08Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
23.08Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
23.08Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
23.08Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
23.08Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
23.08Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
23.08Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.86Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
22.73Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
22.73Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
22.73Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
22.73Single6TP3Nemorexant6TP3-OX1-Nemorexant
22.73Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
22.73Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
22.73Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
22.73Single7VODCariprazine7VOD-5-HT2A-Cariprazine
22.73Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
22.73Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
22.73Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.73Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
22.73Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
22.73Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
22.73Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
22.73Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
22.73Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
22.73Consensusgnrh_offOrthosteric Ligandgnrh1_off
22.73Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
22.73Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
22.73Consensuss1p_offOrthosteric Ligands1p1_off
22.58Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
22.58Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.58Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
22.22Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
22.22Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
22.22Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
22.22Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
22.22Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
22.22Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
22.22Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
22.22Single7WC4Serotonin7WC4-5-HT2A-Serotonin
22.22Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8PWNTheophylline8PWN-A2A-Theophylline
22.22Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
22.22Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
22.22Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.88Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
21.88Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
21.88Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
21.74Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
21.74Single4YAYZD-71554YAY-AT1-ZD-7155
21.74Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
21.74Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
21.74Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
21.74Single6GPSMK08126GPS-CCR2-MK0812
21.74Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
21.74Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
21.74Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
21.74Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
21.74Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
21.74Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
21.74Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
21.74Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
21.74Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
21.74Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
21.43Single4XT1Fractalkine4XT1-US28-Fractalkine
21.43Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
21.43Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
21.43Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
21.43Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
21.43Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
21.43Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
21.43Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
21.43Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
21.21Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
21.21Consensusgo_class-b1Orthosteric Ligandgo_crf
21.21Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
21.05Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
21.05Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
21.05Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
20.83Single5CGCHTL142425CGC-mGlu5-HTL14242
20.83Single6GPXMK08126GPX-CCR2-MK0812
20.83Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
20.83Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
20.83Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
20.83Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
20.83Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
20.83Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
20.83Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
20.83Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
20.83Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
20.83Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
20.83Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
20.69Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
20.69Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
20.69Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
20.59Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
20.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
20.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
20.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
20.00Single5TZR-5TZR-FFA1 (GPR40)-MK8666
20.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
20.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
20.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
20.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
20.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
20.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
20.00Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
20.00Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
20.00Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
20.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
20.00Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
20.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
20.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
20.00Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
20.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
20.00Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
20.00Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
20.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
19.44Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
19.35Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
19.35Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
19.35Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
19.35Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
19.23Single4XEENeurotensin4XEE-NTS1-Neurotensin
19.23Single4XESNeurotensin4XES-NTS1-Neurotensin
19.23Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
19.23Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
19.23Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
19.23Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
19.23Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
19.23Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
19.23Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
19.23Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
19.23Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
19.23Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
19.23Consensusclass-b2_onOrthosteric Ligandadgrg_on
19.23Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
19.23Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
19.23Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
19.23Consensusnts_offOrthosteric Ligandnts1_off
19.23Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
19.05Single3OE9IT1t3OE9-CXCR4-IT1t
19.05Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
19.05Single5L7IVismodegib5L7I-SMO-Vismodegib
19.05Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
19.05Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
19.05Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
19.05Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
19.05Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
18.92Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
18.75Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
18.75Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
18.75Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
18.75Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
18.75Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
18.75Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
18.52Single4BUONeurotensin4BUO-NTS1-Neurotensin
18.52Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
18.52Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
18.52Single5CGDHTL142425CGD-mGlu5-HTL14242
18.52Single6K1QIRL25006K1Q-ETB-IRL2500
18.52Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
18.52Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
18.52Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
18.52Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
18.52Consensuscyslt_offOrthosteric Ligandcyslt2_off
18.52Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
18.52Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
18.52Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.42Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
18.18Single6FJ3PTH6FJ3-PTH1-PTH
18.18Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
18.18Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
18.18Single7F8YDevazepide7F8Y-CCKA-Devazepide
18.18Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
18.18Single7SK3CXCL127SK3-ACKR3-CXCL12
18.18Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
18.18Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
18.18Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
18.18Consensusmglu_onOther Ligandmglu2_on mglu4_on
17.95Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
17.95Consensuspth_onOrthosteric Ligandpth1_on pth2_on
17.86Single5EE7MK08935EE7-Glucagon-MK0893
17.86Single6KNMJN241-96KNM-Apelin-JN241-9
17.86Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
17.65Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
17.65Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
17.39Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
17.39Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
17.39Single6TPKRetosiban6TPK-OT-Retosiban
17.39Single6ZG9GSK10347026ZG9-M1-GSK1034702
17.39Single6ZINSR486926ZIN-NTS1-SR48692
17.39Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
17.39Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
17.39Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
17.39Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
17.39Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
17.39Single8K2WAMG4878K2W-CXCR3-AMG487
17.39Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
17.39Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
17.39Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
17.39Consensusvasopressin-ot_offOrthosteric Ligandot_off
17.24Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
17.24Single7QA8Peptide7QA8-STE2-Peptide
17.24Single7QA8Peptide7QA8-STE2-Peptide
17.24Consensusclass-d_offOrthosteric Ligandste2_off
17.14Single6LMLGlucagon6LML-Glucagon-Glucagon
17.14Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
17.14Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
17.14Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
17.14Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
17.14Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
17.07Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
17.07Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.67Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
16.67Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
16.67Single5TGZAM65385TGZ-CB1-AM6538
16.67Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
16.67Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
16.67Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
16.67Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
16.67Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
16.67Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
16.67Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
16.67Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
16.67Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
16.67Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
16.67Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
16.67Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.22Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
16.22Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
16.22Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
16.22Consensusglp_onOrthosteric Ligandglp1_on glp2_on
16.13Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
16.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
16.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
16.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
16.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
16.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
16.00Single6Z4SSR486926Z4S-NTS1-SR48692
16.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
16.00Single7C4SS1P7C4S-S1P3-S1P
16.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
16.00Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
16.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
16.00Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
16.00Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
16.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
16.00Consensusep_offOrthosteric Ligandep4_off
15.91Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
15.79Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
15.79Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
15.62Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
15.62Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.62Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Consensusclass-d_onOrthosteric Ligandste2_on
15.62Consensusgi_class-dOrthosteric Ligandgi_ste
15.62Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.62Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
15.62Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.38Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
15.38Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
15.38Single5V56TC1145V56-SMO-TC114
15.38Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
15.38Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
15.38Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
15.38Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
15.38Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
15.38Single7P2L4YI7P2L-mGlu5-4YI
15.38Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
15.38Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
15.38Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
15.38Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
15.38Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
15.38Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
15.38Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.38Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
15.15Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
15.15Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
15.15Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
15.15Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
15.15Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
15.15Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.00Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
15.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
14.81Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
14.81Single4PY02MeSATP4PY0-P2Y12-2MeSATP
14.81Single5X33BIIL2605X33-BLT1-BIIL260
14.81Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
14.81Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
14.81Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
14.81Single6YVRNTS8-136YVR-NTS1-NTS8-13
14.81Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
14.81Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
14.81Consensuschemokine_offOrthosteric Ligandcxcr_off
14.81Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
14.81Consensuscxcr_offOrthosteric Ligandcxcr4_off
14.81Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
14.71Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.71Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
14.71Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
14.71Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
14.71Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
14.71Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
14.71Consensusclass-d_onOrthosteric Ligandste2_on
14.71Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
14.29Single3OE6IT1t3OE6-CXCR4-IT1t
14.29Single3OE8IT1t3OE8-CXCR4-IT1t
14.29Single4XNWMRS25004XNW-P2Y1-MRS2500
14.29Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
14.29Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
14.29Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
14.29Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.29Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
14.29Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
14.29Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
14.29Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
14.29Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
14.29Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
14.29Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
14.29Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
14.29Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Consensusgi_class-dOrthosteric Ligandgi_ste
14.29Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
14.29Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.29Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
14.29Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
14.29Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
14.29Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.95Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
13.95Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
13.89Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.89Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
13.89Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
13.89Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
13.89Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
13.89Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
13.89Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.79Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
13.79Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensusclass-d_offOrthosteric Ligandste2_off
13.79Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensusgs_class-b2Orthosteric Ligandgs_adgr
13.79Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
13.64Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
13.64Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.64Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
13.64Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
13.64Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Consensusclass-t_onOrthosteric Ligandtaste2_on
13.64Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
13.64Consensusgo_class-b2Orthosteric Ligandgo_adhesion
13.64Consensusgs_class-tOrthosteric Ligandgs_taste
13.64Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.64Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.51Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
13.33Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
13.33Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
13.04Single3ODUIT1t3ODU-CXCR4-IT1t
13.04Single5ZKQABT-4915ZKQ-PAF-ABT-491
13.04Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
13.04Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
13.04Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.04Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.04Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
13.04Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
13.04Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
13.04Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
13.04Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
12.90Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
12.90Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
12.82Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
12.82Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
12.82Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single6FFIMMPEP6FFI-mGlu5-MMPEP
12.50Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
12.50Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
12.50Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
12.50Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
12.50Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
12.50Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
12.20Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
12.12Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
12.12Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
12.00Single6FFHFenobam6FFH-mGlu5-Fenobam
12.00Single6IIVDaltroban6IIV-TP-Daltroban
12.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
12.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
12.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
12.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
12.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
12.00Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
12.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
12.00Consensushcar_offOrthosteric Ligandsuccinate_off
12.00Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
12.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
12.00Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
11.76Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
11.63Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
11.54Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
11.54Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
11.54Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
11.43Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
11.43Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
11.43Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
11.43Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
11.43Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
11.43Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
11.11Single4BV0Neurotensin4BV0-NTS1-Neurotensin
11.11Single5V57TC1145V57-SMO-TC114
11.11Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
11.11Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
11.11Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
11.11Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
11.11Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
11.11Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
11.11Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
10.81Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
10.81Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
10.71Single6IIURamatroban6IIU-TP-Ramatroban
10.71Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
10.71Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
10.71Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
10.71Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
10.71Consensusnts_onOrthosteric Ligandnts1_on
10.53Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
10.34Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
10.34Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
10.34Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
10.26Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
10.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
10.00Consensusclass-c_onOther Ligandgabab_on mglu_on
9.76Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
9.68Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
9.52Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
9.38Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
9.30Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
9.09Single6LI0GTPL98046LI0-GPR52-GTPL9804
9.09Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
9.09Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
9.09Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
8.82Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
8.70Single4O9RCyclopamine4O9R-SMO-Cyclopamine
8.70Single7UL2SR486927UL2-NTS1-SR48692-Na
8.70Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
8.70Consensusgo_proteinOrthosteric Ligandgo_chemokine
8.70Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
8.33Single4BWBNeurotensin4BWB-NTS1-Neurotensin
8.33Single4QINSAG1.54QIN-SMO-SAG1.5
8.33Single5U09Taranabant5U09-CB1-Taranabant
8.33Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
8.33Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
8.33Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
8.33Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
8.33Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
8.33Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
8.33Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
8.33Consensusclass-f_offOrthosteric Ligandsmo_off
8.33Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.11Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
8.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
8.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
8.00Single8IYXYL-3658IYX-GPR34-YL-365
8.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
8.00Consensusgi_class-fOrthosteric Ligandgi_frizzled
8.00Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
7.89Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
7.69Single7F83PF-051904577F83-Ghrelin-PF-05190457
7.69Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
7.41Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
7.14Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
6.90Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
6.25Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
6.25Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
6.06Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
6.06Single7SHEPI; PE7SHE-GPR158-PI; PE
6.06Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88Consensusclass-c_offOther Ligandgabab_off mglu_off
5.71Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
5.26Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
5.13Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
4.76Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.55Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
4.55Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
4.55Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
4.55Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
4.35Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.35Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
4.35Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
4.35Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
4.35Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
4.35Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
4.35Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
4.17Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
4.17Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
3.85Single7VV6C48/807VV6-MRGPRX2-C48/80
3.85Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.70Single5T04Neurotensin5T04-NTS1-Neurotensin
3.70Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
3.45Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.33Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
3.33Single7SHEPI; PE7SHE-GPR158-PI; PE
3.33Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.23Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
3.03Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
2.94Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.50Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.44Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.44Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.44Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.38Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.33Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.33Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.27Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.27Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.17Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.08Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.04Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.04Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
1.96Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 4IAR
Class A
SubFamily Amine
Type 5-Hydroxytryptamine
SubType 5-HT1B
Species Homo sapiens
Ligand Ergotamine
Other Ligand(s) -
Protein Partners -
PDB Resolution 2.7
Date 2013-03-13
D.O.I. 10.1126/science.1232807
Net Summary
Imin 3.39
Number of Linked Nodes 252
Number of Links 289
Number of Hubs 38
Number of Links mediated by Hubs 150
Number of Communities 6
Number of Nodes involved in Communities 55
Number of Links involved in Communities 78
Path Summary
Number Of Nodes in MetaPath 78
Number Of Links MetaPath 77
Number of Shortest Paths 71501
Length Of Smallest Path 3
Average Path Length 15.234
Length of Longest Path 37
Minimum Path Strength 1.16
Average Path Strength 6.14707
Maximum Path Strength 17.905
Minimum Path Correlation 0.7
Average Path Correlation 0.923123
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.0303
Average % Of Corr. Nodes 45.5689
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.7653
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeERM
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeERM
NameErgotamine
SynonymsErgotamine
Identifiern/a
FormulaC33 H35 N5 O5
Molecular Weight581.661
SMILESC[C@@]1(C(=O)N2[C@H](C(=O)N3CCC[C@H]3[C@@]2(O1)O)Cc4ccccc4)NC(=O)[C@H]5CN([C@@H]6Cc7c[nH]c8c7c(ccc8)C6=C5)C
PubChem8223
Formal Charge0
Total Atoms78
Total Chiral Atoms6
Total Bonds85
Total Aromatic Bonds16

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP28222
Sequence
>4IAR_Chain_R
YIYQDSISL PWKVLLVML LALITLATT LSNAFVIAT VYRTRKLHT 
PANYLIASL AVTDLLVSI LVMPISTMY TVTGRWTLG QVVCDFWLS 
SDITCCTAS IWHLCVIAL DRYWAITDA VEYSAKRTP KRAAVMIAL 
VWVFSISIS LPPFFWRQA SECVVNTDH ILYTVYSTV GAFYFPTLL 
LIALYGRIY VEARSRIAA RERKATKTL GIILGAFIV CWLPFFIIS 
LVMPIWFHL AIFDFFTWL GYLNSLINP IIYTMSNED FKQAFHKLI 
RFK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4IAQAAmine5-Hydroxytryptamine5-HT1BHomo sapiensDihydroergotamine--2.82013-03-1310.1126/science.1232807
5V54AAmine5-Hydroxytryptamine5-HT1BHomo sapiensMethiothepin--3.92018-02-0710.1038/s41421-018-0009-2
6G79AAmine5-Hydroxytryptamine5-HT1BHomo sapiensDonitriptan-Go/&β;1/&γ;23.782018-06-2010.1038/s41586-018-0241-9
7C61AAmine5-Hydroxytryptamine5-HT1BHomo sapiensErgotamine--32020-07-2910.1038/s41598-020-68355-x




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 4IAR.zip



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