Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 7.783571410
2R:R:K49 6.695453
3R:R:N67 5.515409
4R:R:P83 3.6325406
5R:R:L91 4.63529
6R:R:D95 6.72529
7R:R:L96 5.01408
8R:R:S99 5.4725467
9R:R:M103 6.43467
10R:R:W115 6.77833688
11R:R:W125 10.0475406
12R:R:T131 3.205406
13R:R:W138 8.3475406
14R:R:H139 7.302527
15R:R:L140 7.4428
16R:R:I143 5.53429
17R:R:D146 4.6575479
18R:R:Y148 7.69438
19R:R:T152 5.93437
20R:R:Y157 10.0475478
21R:R:R161 6.425477
22R:R:Y208 7.2725448
23R:R:Y218 5.648506
24R:R:Y232 8.78496
25R:R:F323 4.736509
26R:R:W327 7.27857717
27R:R:F330 6.914518
28R:R:F331 12.246517
29R:R:F351 8.99414
30R:R:F354 6.4725406
31R:R:W356 8.69667616
32R:R:Y359 6.13833617
33R:R:N365 9.2429
34R:R:I368 3.8225428
35R:R:Y369 6.19529
36R:R:F376 9.468508
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:D129 31.29778.29YesNo108
2R:R:D129 R:R:Y359 16.04189.2NoYes187
3R:R:W356 R:R:Y359 20.13928.68YesYes167
4R:R:V98 R:R:Y359 70.9253.79NoYes087
5R:R:M103 R:R:V98 25.56134.56YesNo078
6L:L:?1 R:R:W327 58.31843.86YesYes107
7R:R:N361 R:R:W327 54.15364.52NoYes097
8R:R:N361 R:R:N365 55.343513.62NoYes099
9R:R:L91 R:R:N365 37.80874.12YesYes299
10R:R:I143 R:R:L91 1004.28YesYes299
11R:R:I143 R:R:L87 87.18014.28YesNo097
12R:R:D146 R:R:L87 85.18195.43YesNo097
13R:R:D146 R:R:R161 69.92594.76YesYes797
14R:R:P83 R:R:R161 67.0977.21YesYes067
15R:R:P83 R:R:T82 49.47243.5YesNo068
16R:R:N85 R:R:T82 39.4147.31NoNo098
17R:R:L80 R:R:N85 30.02926.87NoNo089
18R:R:F376 R:R:L80 27.80653.65YesNo088
19R:R:F376 R:R:F380 18.17478.57YesNo087
20R:R:D95 R:R:N365 18.78098.08YesYes299
21R:R:D95 R:R:N67 35.36156.73YesYes099
22R:R:L96 R:R:S99 14.7624.5YesYes087
23R:R:L96 R:R:N67 24.80924.12YesYes089
24R:R:P163 R:R:P83 15.9521.95NoYes036
25R:R:P163 R:R:Y86 10.5862.78NoNo035
26R:R:H139 R:R:L91 75.19085.14YesYes279
27R:R:I137 R:R:W327 22.474210.57NoYes087
28R:R:F323 R:R:I137 23.24886.28YesNo098
29R:R:F323 R:R:L140 54.56894.87YesYes098
30R:R:L140 R:R:N365 21.5210.98YesYes289
31R:R:S362 R:R:V98 65.50298.08NoNo098
32R:R:I100 R:R:L96 13.05577.14NoYes058
33R:R:D129 R:R:V102 14.72838.76NoNo187
34R:R:V102 R:R:W125 36.15854.9NoYes076
35R:R:I105 R:R:W125 44.824924.66NoYes066
36R:R:I105 R:R:W115 36.76475.87NoYes068
37R:R:L117 R:R:W115 12.75265.69NoYes068
38R:R:W115 R:R:Y109 12.75262.89YesNo086
39R:R:L126 R:R:W125 11.69745.69NoYes066
40L:L:?1 R:R:T134 38.17925YesNo007
41R:R:S177 R:R:T134 33.01536.4NoNo087
42R:R:S177 R:R:T131 30.34353.2NoYes086
43R:R:S181 R:R:T131 22.19353.2NoYes076
44R:R:S127 R:R:S181 19.4323.26NoNo077
45R:R:F185 R:R:S127 16.63671.32NoNo077
46R:R:D123 R:R:F185 13.81913.14NoNo067
47R:R:H139 R:R:V173 63.74055.54YesNo077
48R:R:V173 R:R:W138 53.58113.68NoYes076
49R:R:C141 R:R:W138 38.41496.53NoYes076
50R:R:F176 R:R:W138 10.226811.02NoYes056
51R:R:L140 R:R:Y369 45.29648.21YesYes289
52R:R:C141 R:R:L223 36.15854.76NoNo077
53R:R:V142 R:R:V173 10.22681.6NoNo067
54R:R:D146 R:R:Y157 11.24836.9YesYes798
55R:R:L223 R:R:L227 33.87978.3NoNo076
56R:R:L227 R:R:Y148 29.25465.86NoYes068
57R:R:T152 R:R:Y148 17.06338.74YesYes378
58R:R:D153 R:R:T152 10.1371.45NoYes067
59L:L:?1 R:R:M337 14.35799.59YesNo004
60R:R:T213 R:R:Y218 10.26043.75NoYes066
61R:R:F217 R:R:Y218 16.176512.38NoYes086
62R:R:V214 R:R:Y218 10.49623.79NoYes036
63R:R:F217 R:R:T221 13.8197.78NoNo086
64R:R:F323 R:R:L224 12.78634.87YesNo098
65R:R:R147 R:R:Y369 16.67048.23NoYes299
66R:R:R147 R:R:Y228 42.29915.14NoNo099
67R:R:I319 R:R:Y228 12.22513.3NoNo089
68R:R:L316 R:R:Y228 28.17697.03NoNo089
69R:R:L316 R:R:Y232 25.482712.89NoYes086
70R:R:I143 R:R:R147 28.36787.52YesNo299
71R:R:I368 R:R:Y369 19.69024.84YesYes289
72R:R:F323 R:R:I324 28.2783.77YesNo096
73R:R:I324 R:R:L328 25.22454.28NoNo066
74R:R:L328 R:R:P329 22.14863.28NoNo069
75R:R:F354 R:R:P329 15.929511.56YesNo069
76R:R:E309 R:R:Y232 16.1546.73NoYes986
77R:R:A312 R:R:E309 13.43741.51NoNo088
78R:R:A312 R:R:I239 10.09211.62NoNo085
79R:R:D95 R:R:S362 66.31127.36YesNo099
80R:R:D95 R:R:L91 81.6124.07YesYes299
81R:R:S106 R:R:Y359 24.57346.36NoYes167
82R:R:F323 R:R:T221 15.07633.89YesNo096
83R:R:V102 R:R:Y359 23.78765.05NoYes177
84R:R:S106 R:R:W125 23.57434.94NoYes066
85R:R:L140 R:R:L91 31.74675.54YesYes289
86R:R:I143 R:R:Y369 18.84826.04YesYes299
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D129 8.29 1 Yes No 0 8 0 1
L:L:?1 R:R:I130 16.46 1 Yes No 0 6 0 1
L:L:?1 R:R:C133 5.38 1 Yes No 0 6 0 1
L:L:?1 R:R:T134 5 1 Yes No 0 7 0 1
L:L:?1 R:R:V201 7.07 1 Yes No 0 6 0 1
L:L:?1 R:R:W327 3.86 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F330 10.74 1 Yes Yes 0 8 0 1
L:L:?1 R:R:F331 11.57 1 Yes Yes 0 7 0 1
L:L:?1 R:R:S334 6.11 1 Yes No 0 6 0 1
L:L:?1 R:R:M337 9.59 1 Yes No 0 4 0 1
L:L:?1 R:R:L348 7.51 1 Yes No 0 2 0 1
L:L:?1 R:R:F351 12.39 1 Yes Yes 0 4 0 1
R:R:D129 R:R:V102 8.76 1 No No 8 7 1 2
R:R:V102 R:R:Y359 5.05 1 No Yes 7 7 2 2
R:R:D129 R:R:Y359 9.2 1 No Yes 8 7 1 2
R:R:C133 R:R:W327 6.53 1 No Yes 6 7 1 1
R:R:S177 R:R:T134 6.4 0 No No 8 7 2 1
R:R:A216 R:R:T134 5.03 0 No No 7 7 2 1
R:R:I137 R:R:W327 10.57 0 No Yes 8 7 2 1
R:R:F331 R:R:T213 6.49 1 Yes No 7 6 1 2
R:R:S334 R:R:T213 7.99 0 No No 6 6 1 2
R:R:F217 R:R:F331 25.72 0 No Yes 8 7 2 1
R:R:F330 R:R:W327 6.01 1 Yes Yes 8 7 1 1
R:R:F331 R:R:W327 11.02 1 Yes Yes 7 7 1 1
R:R:G358 R:R:W327 8.44 0 No Yes 7 7 2 1
R:R:N361 R:R:W327 4.52 0 No Yes 9 7 2 1
R:R:F330 R:R:F331 6.43 1 Yes Yes 8 7 1 1
R:R:F330 R:R:F351 7.5 1 Yes Yes 8 4 1 1
R:R:F330 R:R:T355 3.89 1 Yes No 8 6 1 2
R:R:F351 R:R:L348 12.18 1 Yes No 4 2 1 1
R:R:F351 R:R:T355 3.89 1 Yes No 4 6 1 2
R:R:T355 R:R:Y359 3.75 1 No Yes 6 7 2 2
R:R:M337 R:R:V336 3.04 0 No No 4 5 1 2
L:L:?1 R:R:T209 3 1 Yes No 0 6 0 1
L:L:?1 R:R:T203 2 1 Yes No 0 7 0 1
R:R:M337 R:R:P338 1.68 0 No No 4 5 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 6G79_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.68
Number of Linked Nodes 231
Number of Links 260
Number of Hubs 36
Number of Links mediated by Hubs 143
Number of Communities 9
Number of Nodes involved in Communities 51
Number of Links involved in Communities 68
Path Summary
Number Of Nodes in MetaPath 87
Number Of Links MetaPath 86
Number of Shortest Paths 28386
Length Of Smallest Path 3
Average Path Length 11.4507
Length of Longest Path 27
Minimum Path Strength 1.45
Average Path Strength 6.27072
Maximum Path Strength 19.05
Minimum Path Correlation 0.7
Average Path Correlation 0.904081
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4
Average % Of Corr. Nodes 49.9247
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.3297
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• cation binding   • binding   • ion binding   • serotonin binding   • amine binding   • heterocyclic compound binding   • small molecule binding   • G protein-coupled amine receptor activity   • G protein-coupled serotonin receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • Gi/o-coupled serotonin receptor activity   • neurotransmitter receptor activity   • serotonin receptor activity   • multicellular organismal process   • tissue remodeling   • bone remodeling   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Gene OntologyBiological Process• multicellular organismal process   • tissue remodeling   • bone remodeling   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • monoamine transport   • regulation of localization   • nitrogen compound transport   • transport   • negative regulation of monoatomic ion transport   • negative regulation of biological process   • negative regulation of transport   • organic hydroxy compound transport   • localization   • secretion by cell   • negative regulation of secretion   • regulation of secretion by cell   • signal release   • negative regulation of cellular process   • monoatomic ion transport   • negative regulation of secretion by cell   • serotonin secretion   • negative regulation of serotonin secretion   • regulation of transport   • secretion   • regulation of monoatomic ion transport   • cell-cell signaling   • export from cell   • serotonin transport   • regulation of serotonin secretion   • establishment of localization   • regulation of secretion   • phospholipase C-activating serotonin receptor signaling pathway   • phospholipase C-activating G protein-coupled receptor signaling pathway   • regulation of tube diameter   • system process   • regulation of tube size   • circulatory system process   • vascular process in circulatory system   • blood vessel diameter maintenance   • regulation of biological quality   • vasoconstriction   • blood circulation   • regulation of anatomical structure size   • regulation of vascular associated smooth muscle cell proliferation   • cell population proliferation   • positive regulation of vascular associated smooth muscle cell proliferation   • regulation of smooth muscle cell proliferation   • positive regulation of cell population proliferation   • positive regulation of biological process   • smooth muscle cell proliferation   • positive regulation of smooth muscle cell proliferation   • regulation of cell population proliferation   • muscle cell proliferation   • vascular associated smooth muscle cell proliferation   • positive regulation of cellular process   • cellular response to nitrogen compound   • cellular response to chemical stimulus   • response to chemical   • response to nitrogen compound   • cellular response to alkaloid   • response to alkaloid   • regulation of behavior   • behavior   • regulation of multicellular organismal process   • trans-synaptic signaling   • synaptic signaling   • anterograde trans-synaptic signaling   • chemical synaptic transmission   • cellular response to xenobiotic stimulus   • response to xenobiotic stimulus   • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger   • protein-containing complex   • G protein-coupled serotonin receptor complex   • receptor complex   • cellular anatomical structure   • serotonergic synapse   • synapse   • cell junction   • cell periphery   • plasma membrane   • membrane   • presynapse   • presynaptic membrane   • plasma membrane region   • synaptic membrane
Gene OntologyCellular Component• protein-containing complex   • G protein-coupled serotonin receptor complex   • receptor complex   • cellular anatomical structure   • serotonergic synapse   • synapse   • cell junction   • cell periphery   • plasma membrane   • membrane   • presynapse   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • membrane-bounded organelle   • intracellular organelle   • intracellular anatomical structure   • organelle   • endoplasmic reticulum   • cytoplasm   • intracellular membrane-bounded organelle   • endomembrane system   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • adenylate cyclase regulator activity   • mu-type opioid receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • opioid receptor binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • peptide hormone receptor binding   • corticotropin-releasing hormone receptor binding   • corticotropin-releasing hormone receptor 1 binding   • hormone receptor binding   • neuropeptide receptor binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cation binding   • metal ion binding   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • heart process   • multicellular organismal process   • system process   • regulation of heart contraction   • regulation of system process   • circulatory system process   • regulation of blood circulation   • regulation of multicellular organismal process   • heart contraction   • blood circulation   • behavior   • locomotory behavior   • transport   • secretion   • export from cell   • membrane docking   • establishment of localization   • vesicle-mediated transport   • localization   • organelle localization by membrane tethering   • secretion by cell   • exocytosis   • organelle localization   • vesicle docking   • exocytic process   • vesicle docking involved in exocytosis   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • amide transport   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • regulation of peptide transport   • regulation of establishment of protein localization   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • trans-synaptic signaling   • modulation of chemical synaptic transmission   • chemical synaptic transmission   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • postsynaptic modulation of chemical synaptic transmission   • muscle contraction   • muscle system process   • postsynapse   • postsynaptic membrane   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • parallel fiber to Purkinje cell synapse   • excitatory synapse   • GABA-ergic synapse   • glutamatergic synapse   • cell body   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • adenylate cyclase-activating dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • organelle membrane   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome
SCOP2Domain Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeEP5
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeEP5
Name2-[5-[2-[4-(4-cyanophenyl)piperazin-1-yl]-2-oxidanylidene-ethoxy]-1~{H}-indol-3-yl]ethylazanium
Synonyms
Identifier
FormulaC23 H26 N5 O2
Molecular Weight404.485
SMILES
PubChem137349273
Formal Charge1
Total Atoms56
Total Chiral Atoms0
Total Bonds59
Total Aromatic Bonds16

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP28222
Sequence
>6G79_nogp_Chain_R
SLPWKVLLV MLLALITLA TTLSNAFVI ATVYRTRKL HTPANYLIA 
SLAVTDLLV SILVMPIST MYTVTGRWT LGQVVCDFW LSSDITCCT 
ASIWHLCVI ALDRYWAIT DAVEYSAKR TPKRAAVMI ALVWVFSIS 
ISLPPFFWS ECVVNTDHI LYTVYSTVG AFYFPTLLL IALYGRIYV 
EARSRILMA ARERKATKT LGIILGAFI VCWLPFFII SLVMPWFHL 
AIFDFFTWL GYLNSLINP IIYTMSNED FKQAFHKLI R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5V54AAmine5-Hydroxytryptamine5-HT1BHomo sapiensMethiothepin--3.92018-02-07doi.org/10.1038/s41421-018-0009-2
6G79AAmine5-Hydroxytryptamine5-HT1BHomo sapiensDonitriptan-Go/β1/γ23.782018-06-20doi.org/10.1038/s41586-018-0241-9
6G79 (No Gprot) AAmine5-Hydroxytryptamine5-HT1BHomo sapiensDonitriptan-3.782018-06-20doi.org/10.1038/s41586-018-0241-9
7C61AAmine5-Hydroxytryptamine5-HT1BHomo sapiensErgotamine--32020-07-29doi.org/10.1038/s41598-020-68355-x
4IAQAAmine5-Hydroxytryptamine5-HT1BHomo sapiensDihydroergotamine--2.82013-03-13doi.org/10.1126/science.1232807
4IARAAmine5-Hydroxytryptamine5-HT1BHomo sapiensErgotamine--2.72013-03-13doi.org/10.1126/science.1232807




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Download 6G79_nogp.zip



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