Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
NTNT8.213331YesYes4411
LigNT35.621YesYes0401
1x24Lig7.551670NoYes3010
1x357x356.138330YesNo6321
2x533x324.128330NoYes7721
2x537x424.760NoYes7822
2x562x603.886670NoNo7721
2x603x329.4751NoYes7711
2x60Lig11.9151NoYes7010
2x63E1x506.088331NoYes4912
2x63Lig6.791671NoYes4010
E1x49E213.83331NoYes3321
E1x50E24.558331YesYes9321
3x22E28.718331NoYes3321
3x32Lig4.001671YesYes7010
3x366x486.156670NoYes7922
4x64E212.45171NoYes5321
4x645x354.843331NoYes5322
E2E241.051YesYes3311
E2Lig42.32671YesYes3010
E2E2x5112.37831YesNo3311
E2x51Lig5.4351NoYes3010
E2E2x527.4851YesNo3412
5x35E211.551YesYes3321
5x36E27.868331NoYes4321
5x39E25.611NoYes5321
5x32Lig3.961671NoYes3010
5x345x3511.961NoYes1322
5x446x564.358331NoNo5512
6x486x515.471671YesYes9721
6x516x554.171YesNo7612
6x517x386.641671YesNo7611
6x51Lig10.8051YesYes7010
6x58Lig7.646671NoYes4010
7x27Lig8.130NoYes3010
7x31Lig6.226671NoYes4010
7x34Lig5.270NoYes5010
7x357x395.673331NoNo3612
7x35Lig4.1151NoYes3010
7x38Lig4.581671NoYes6010
5x325x353.911671NoYes3312
7x387x426.131NoYes6812
3x323x364.086671YesNo7712
E3E37.971YesYes4422
E3NT4.546671YesYes4421
E2NT4.771YesYes3411
5x325x345.111NoNo3112
6x58E35.476671NoYes4412
5x44Lig3.741NoYes5010
7x24NT3.640NoYes6421
1x277x313.40NoNo1421
6x517x373.343331YesYes7712
1x25NT3.110NoYes3421
6x54Lig3.070NoYes5010
5x31E22.783330NoYes3321
E1NT1.916670NoYes0421
1x28E20.8733330NoYes1321

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Consensus Members
Id Members
ccr_off ccr5_off
ccr8_off
chemokine_off cxcr_off
gnrh_off gnrh1_off
Net Summary
Imin 3.85333
Number of Linked Nodes 284
Number of Links 306
Number of Hubs 33
Number of Links mediated by Hubs 156
Number of Communities 4
Number of Nodes involved in Communities 41
Number of Links involved in Communities 55
Path Summary
Number Of Nodes in MetaPath 53
Number Of Links MetaPath 52
Number of Shortest Paths 45343
Length Of Smallest Path 3
Average Path Length 12.2016
Length of Longest Path 31
Minimum Path Strength 1.2625
Average Path Strength 6.42834
Maximum Path Strength 27.3892
Minimum Path Correlation 0.7
Average Path Correlation 0.909241
Maximum Path Correlation 0.986667
Minimum % Of Corr. Nodes 3.57143
Average % Of Corr. Nodes 40.7563
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 43.0943
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
protein_off_onprotein_offprotein_on
This network is also present in following consensuses:
IdComponents
class-a_offsensory_off
amine_off
lipid_off
nucleotide_off
peptide_off
protein_off
hcar_off



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download protein_off.zip



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