psnGPCR

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Orange: nodes, hubs and links specific of protein_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of protein_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	protein_off Int. Strength	protein_on Int. Strength	protein_off Hub1?	protein_on Hub1?	protein_off Hub2?	protein_on Hub2?	ConSurf1	ConSurf2
1	1x53	1x57	protein_off	100	0	Yes	No	No	No	9	7
2	1x53	7x50	protein_off	100	0	Yes	No	No	No	9	9
3	1x53	7x53	protein_off	100	0	Yes	No	Yes	Yes	9	9
4	1x56	1x60	protein_off	100	0	No	No	Yes	Yes	7	5
5	2x38	3x49	protein_off	100	0	Yes	No	Yes	No	6	8
6	2x39	3x50	protein_off	100	0	No	No	Yes	No	7	9
7	2x45	4x50	protein_off	100	0	No	No	Yes	No	9	9
8	2x53	3x36	protein_off	100	0	Yes	Yes	No	No	6	7
9	2x53	6x48	protein_off	100	0	Yes	Yes	Yes	Yes	6	9
10	2x54	2x57	protein_off	100	0	No	No	No	No	6	7
11	2x56	2x60	protein_off	100	0	No	No	No	No	7	6
12	E1x50	E2	protein_off	100	0	Yes	Yes	Yes	Yes	8	3
13	3x22	3x26	protein_off	100	0	No	No	No	No	3	7
14	3x33	3x37	protein_off	100	0	No	No	Yes	No	5	7
15	3x36	5x43	protein_off	100	0	No	No	No	No	7	5
16	3x37	3x41	protein_off	100	0	Yes	No	No	No	7	5
17	3x37	5x46	protein_off	100	0	Yes	No	No	No	7	4
18	3x40	6x44	protein_off	100	0	No	No	Yes	No	8	9
19	3x42	4x50	protein_off	100	0	Yes	No	Yes	No	7	9
20	3x49	3x50	protein_off	100	0	Yes	No	Yes	No	8	9
21	3x50	3x53	protein_off	100	0	Yes	No	No	No	9	8
22	3x50	6x30	protein_off	100	0	Yes	No	No	No	9	5
23	3x50	6x33	protein_off	100	0	Yes	No	No	No	9	7
24	3x50	6x37	protein_off	100	0	Yes	No	No	No	9	7
25	4x61	5x39	protein_off	100	0	No	No	No	No	4	5
26	4x64	5x35	protein_off	100	0	No	No	Yes	No	4	3
27	5x42	5x46	protein_off	100	0	No	No	No	No	4	4
28	5x58	6x38	protein_off	100	0	Yes	Yes	No	No	8	4
29	6x35	7x56	protein_off	100	0	No	No	Yes	No	5	6
30	6x36	7x53	protein_off	100	0	No	No	Yes	Yes	8	9
31	6x40	7x49	protein_off	100	0	No	No	No	No	8	9
32	6x44	7x45	protein_off	100	0	Yes	No	Yes	No	9	9
33	6x48	6x51	protein_off	100	0	Yes	Yes	Yes	Yes	9	6
34	6x59	6x60	protein_off	100	0	No	Yes	No	No	5	4
35	7x35	Lig	protein_off	100	0	Yes	No	Yes	Yes	4	0
36	7x42	Lig	protein_off	100	0	Yes	Yes	Yes	Yes	7	0
37	1x50	2x47	protein_off	100	0	Yes	No	No	No	9	9
38	2x50	7x46	protein_off	100	0	Yes	Yes	No	No	9	8
39	E1x49	E1x51	protein_off	100	0	No	No	No	No	4	3
40	5x34	5x35	protein_off	100	0	No	No	Yes	No	2	3
41	5x34	5x38	protein_off	100	0	No	No	No	No	2	4
42	7x35	7x39	protein_off	100	0	Yes	No	No	No	4	5
43	3x37	5x461	protein_off	100	0	Yes	No	No	No	7	6
44	3x43	5x54	protein_off	100	0	No	No	No	No	8	8
45	4x61	4x65	protein_off	100	0	No	No	Yes	No	4	5
46	6x58	E3	protein_off	100	0	No	No	Yes	Yes	4	0
47	E3	E3	protein_off	100	0	Yes	Yes	Yes	Yes	0	0
48	4x56	5x42	protein_off	100	0	No	No	No	No	5	4
49	7x36	7x37	protein_off	100	0	No	No	No	No	5	7
50	7x45	7x46	protein_off	100	0	Yes	No	No	No	9	8
51	5x461	6x52	protein_off	100	0	No	No	No	No	6	8
52	5x44	Lig	protein_off	100	0	No	No	Yes	Yes	5	0
53	6x54	Lig	protein_off	100	0	No	No	Yes	Yes	5	0
54	E3	NT	protein_off	100	0	Yes	Yes	Yes	Yes	0	0
55	E2	NT	protein_off	100	0	Yes	Yes	Yes	Yes	3	0
56	5x40	NT	protein_off	100	0	No	No	Yes	Yes	5	0
57	6x58	NT	protein_off	100	0	No	No	Yes	Yes	4	0
58	3x32	NT	protein_off	100	0	No	No	Yes	Yes	6	0
59	4x65	NT	protein_off	100	0	Yes	No	Yes	Yes	5	0
60	2x39	6x33	protein_off	100	0	No	No	No	No	7	7
61	2x53	3x39	protein_off	100	0	Yes	Yes	No	No	6	9
62	2x64	E1x50	protein_off	100	0	No	No	Yes	Yes	5	8
63	4x40	4x43	protein_off	100	0	No	No	No	No	4	4
64	5x68	6x26	protein_off	100	0	No	No	No	No	0	0
65	6x26	6x31	protein_off	100	0	No	No	No	No	0	4
66	7x30	7x33	protein_off	100	0	No	No	No	No	4	5
67	7x53	7x57	protein_off	100	0	Yes	Yes	No	No	9	0
68	7x55	7x56	protein_off	100	0	No	Yes	Yes	No	7	6
69	5x51	6x45	protein_off	75	0	No	No	No	No	6	5
70	1x40	2x62	protein_off	50	0	No	No	Yes	No	3	4
71	6x43	7x45	protein_off	50	0	No	No	Yes	No	6	9
72	1x45	1x49	protein_off	50	0	No	No	No	No	6	7
73	2x38	4x42	protein_off	50	0	Yes	No	No	No	6	7
74	5x51	5x55	protein_off	50	0	No	No	No	No	6	4
75	2x38	4x41	protein_off	66.6667	0	Yes	No	No	Yes	6	4
76	6x54	7x37	protein_off	50	0	No	No	No	No	5	7
77	5x32	5x35	protein_off	62.5	0	No	No	Yes	No	4	3
78	1x35	7x31	protein_off	50	0	Yes	Yes	No	No	6	4
79	7x30	7x32	protein_off	50	0	No	No	No	No	4	1
80	2x40	7x53	protein_off	62.5	0	Yes	No	Yes	Yes	8	9
81	3x45	4x45	protein_off	50	0	No	No	No	No	6	5
82	4x59	4x60	protein_off	12.5	0	No	No	No	No	5	7
83	3x30	4x57	protein_off	25	0	No	No	No	No	6	7
84	1x48	1x49	protein_off	50	0	No	No	No	No	4	7
85	3x51	3x56	protein_off	50	0	Yes	No	No	No	8	6
86	4x52	4x56	protein_off	75	0	No	No	No	No	4	5
87	6x29	6x33	protein_off	50	0	No	No	No	No	4	7
88	6x36	7x56	protein_off	50	0	No	No	Yes	No	8	6
89	1x59	1x60	protein_off	62.5	0	No	Yes	Yes	Yes	4	5
90	5x61	6x34	protein_off	50	0	No	No	No	No	8	6
91	2x46	3x42	protein_off	25	0	No	No	Yes	No	9	7
92	7x33	E3	protein_off	50	0	No	No	Yes	Yes	5	0
93	1x50	2x51	protein_off	25	0	Yes	No	No	No	9	7
94	5x65	6x34	protein_off	62.5	0	No	No	No	No	8	6
95	1x60	7x53	protein_off	50	0	Yes	Yes	Yes	Yes	5	9
96	E1	NT	protein_off	50	0	No	No	Yes	Yes	0	0
97	3x41	4x53	protein_off	0	0	No	No	No	No	5	8
98	2x551	3x31	protein_off	50	0	No	No	No	No	0	4
99	3x54	6x34	protein_off	54.1667	0	No	No	No	No	8	6
100	1x42	7x39	protein_off	50	0	No	No	No	No	7	5
101	5x65	5x69	protein_off	50	0	No	No	No	No	8	0
102	2x49	4x50	protein_off	29.1667	0	No	No	Yes	No	8	9
103	2x48	4x50	protein_off	0	0	No	No	Yes	No	5	9
104	5x33	5x37	protein_off	50	0	No	No	No	No	3	3
105	1x46	7x47	protein_off	0	0	No	No	No	No	8	8
106	5x47	5x48	protein_off	50	0	Yes	No	No	No	8	5
107	5x47	5x51	protein_off	12.5	0	Yes	No	No	No	8	6
108	3x30	3x34	protein_off	0	0	No	No	No	No	6	6
109	7x53	8x50	protein_off	50	0	Yes	Yes	No	Yes	9	8
110	1x24	1x27	protein_off	50	0	No	No	No	No	0	5
111	6x62	E3	protein_off	50	0	No	No	Yes	Yes	3	0
112	7x47	7x48	protein_off	50	0	No	No	No	No	8	6
113	6x32	8x48	protein_off	50	0	No	No	No	No	6	5
114	7x36	7x40	protein_off	50	0	No	No	No	No	5	7
115	1x54	2x47	protein_off	0	0	No	No	No	No	8	9
116	2x40	I1x48	protein_off	50	0	Yes	No	No	No	8	6
117	3x48	5x53	protein_off	12.5	0	No	No	No	No	6	6
118	7x53	7x54	protein_off	50	0	Yes	Yes	No	No	9	7
119	5x58	5x61	protein_off	16.6667	0	Yes	Yes	No	No	8	8
120	5x45	5x49	protein_off	12.5	0	No	No	No	No	4	6
121	1x38	7x35	protein_off	50	0	No	No	Yes	No	5	4
122	5x37	6x60	protein_off	50	0	No	No	No	No	3	4
123	2x41	2x42	protein_off	12.5	0	No	No	Yes	Yes	7	7
124	1x40	1x44	protein_off	0	0	No	No	No	No	3	6
125	1x43	1x44	protein_off	0	0	Yes	No	No	No	7	6
126	5x65	6x31	protein_off	0	0	No	No	No	No	8	4
127	6x26	6x27	protein_off	0	0	No	No	No	No	0	1
128	6x63	6x64	protein_off	25	0	No	No	No	No	1	1
129	4x38	4x42	protein_off	25	0	No	No	No	No	7	7
130	2x62	2x66	protein_off	25	0	Yes	No	No	No	4	4
131	4x39	4x41	protein_off	0	0	No	No	No	Yes	3	4
132	6x62	6x63	protein_off	25	0	No	No	No	No	3	1
133	1x47	1x51	protein_off	25	0	No	No	No	No	6	4
134	1x36	2x65	protein_off	25	0	No	No	No	No	5	4
135	1x36	2x62	protein_off	0	0	No	No	Yes	No	5	4
136	1x32	1x35	protein_off	0	0	No	No	Yes	Yes	7	6
137	6x49	6x53	protein_off	0	0	No	No	No	No	5	6
138	3x48	3x52	protein_off	25	0	No	No	No	No	6	5
139	1x36	1x37	protein_off	25	0	No	No	No	No	5	5
140	5x62	5x66	protein_off	12.5	0	No	No	No	No	4	4
141	1x58	I1	protein_off	0	0	No	No	No	No	3	0
142	1x33	NT	protein_off	0	0	No	No	Yes	Yes	5	0
143	2x44	I1x50	protein_off	25	0	No	No	No	No	6	6
144	6x42	6x46	protein_off	0	0	No	No	No	No	5	6
145	6x28	6x31	protein_off	25	0	No	No	No	No	3	4
146	8x54	8x55	protein_off	25	0	Yes	No	No	No	7	5
147	5x59	5x60	protein_off	0	0	No	No	Yes	No	4	4
148	1x25	1x29	protein_off	25	0	No	No	No	No	0	4
149	7x23	7x25	protein_off	25	0	No	No	No	No	0	0
150	1x24	7x28	protein_off	25	0	No	No	No	No	0	3
151	3x49	I2x54	protein_off	25	0	Yes	No	No	No	8	5
152	5x31	E2	protein_off	25	0	No	No	Yes	Yes	0	3
153	3x52	I2x51	protein_off	25	0	No	No	No	No	5	5
154	1x56	8x54	protein_off	25	0	No	No	Yes	No	7	7
155	1x60	8x57	protein_off	12.5	0	Yes	Yes	No	No	5	5
156	1x34	1x35	protein_off	16.6667	0	No	No	Yes	Yes	5	6
157	1x29	1x31	protein_off	0	0	No	No	No	No	4	3
158	3x52	I2x53	protein_off	16.6667	0	No	No	No	No	5	5
159	1x60	8x56	protein_off	0	0	Yes	Yes	No	No	5	4
160	3x45	4x40	protein_off	25	0	No	No	No	No	6	4
161	1x60	CT	protein_off	12.5	0	Yes	Yes	No	No	5	4
162	I2x52	I2x55	protein_off	25	0	No	Yes	No	No	4	4
163	8x48	8x51	protein_off	12.5	0	No	No	No	No	5	8
164	7x53	8x49	protein_off	12.5	0	Yes	Yes	No	No	9	6
165	8x55	8x59	protein_off	12.5	0	No	No	No	No	5	0
166	5x60	5x63	protein_off	0	0	Yes	No	No	No	4	4
167	1x26	7x28	protein_off	12.5	0	No	No	No	No	0	3
168	I2	I2x57	protein_off	12.5	0	No	No	No	Yes	0	7
169	2x37	I2x55	protein_off	12.5	0	No	No	No	No	7	4
170	8x48	8x52	protein_off	12.5	0	No	No	No	No	5	4
171	6x30	I3	protein_off	4.16667	0	No	No	No	No	5	0
172	6x65	E3	protein_off	0	0	No	No	Yes	Yes	0	0
173	6x32	I2x50	protein_off	0	0	No	No	No	No	6	7
174	1x35	1x39	Shared	100	100	Yes	Yes	Yes	Yes	6	7
175	1x39	7x39	Shared	100	21.25	Yes	Yes	No	No	7	5
176	1x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	7	7
177	1x42	7x43	Shared	100	26.6667	No	No	No	No	7	5
178	1x43	2x58	Shared	100	100	Yes	No	No	No	7	9
179	1x46	2x54	Shared	100	100	No	No	No	No	8	6
180	1x50	2x50	Shared	100	100	Yes	No	Yes	Yes	9	9
181	1x50	7x50	Shared	100	100	Yes	No	No	No	9	9
182	1x53	2x47	Shared	100	25	Yes	No	No	No	9	9
183	2x38	2x42	Shared	100	100	Yes	No	Yes	Yes	6	7
184	2x42	3x45	Shared	100	100	Yes	Yes	No	No	7	6
185	2x42	3x46	Shared	100	100	Yes	Yes	No	No	7	9
186	2x42	3x49	Shared	100	100	Yes	Yes	Yes	No	7	8
187	2x43	7x53	Shared	100	55	No	No	Yes	Yes	8	9
188	2x45	3x42	Shared	100	100	No	No	Yes	No	9	7
189	2x45	4x46	Shared	100	100	No	No	No	No	9	7
190	2x50	7x49	Shared	100	100	Yes	Yes	No	No	9	9
191	2x53	3x35	Shared	100	100	Yes	Yes	No	No	6	8
192	2x53	7x46	Shared	100	100	Yes	Yes	No	No	6	8
193	2x57	7x42	Shared	100	100	No	No	Yes	Yes	7	7
194	2x59	E1x52	Shared	100	100	No	No	Yes	Yes	6	7
195	2x59	3x28	Shared	100	100	No	No	No	No	6	6
196	2x60	3x32	Shared	100	100	No	No	No	No	6	6
197	2x60	Lig	Shared	100	100	No	No	Yes	Yes	6	0
198	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	4	8
199	E1x49	E2	Shared	100	100	No	No	Yes	Yes	4	3
200	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
201	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	8
202	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	8	9
203	3x22	E2	Shared	100	100	No	No	Yes	Yes	3	3
204	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
205	3x29	4x65	Shared	100	100	No	No	Yes	No	6	5
206	3x30	4x62	Shared	100	100	No	No	No	No	6	5
207	3x32	Lig	Shared	100	100	No	No	Yes	Yes	6	0
208	3x33	4x61	Shared	100	50	No	No	No	No	5	4
209	3x34	4x50	Shared	100	100	No	No	Yes	No	6	9
210	3x36	6x48	Shared	100	100	No	No	Yes	Yes	7	9
211	3x37	4x56	Shared	100	100	Yes	No	No	No	7	5
212	3x37	5x43	Shared	100	100	Yes	No	No	No	7	5
213	3x38	4x50	Shared	100	100	No	No	Yes	No	7	9
214	3x40	5x50	Shared	100	0	No	No	No	Yes	8	8
215	3x42	4x49	Shared	100	100	Yes	No	No	No	7	7
216	3x47	5x58	Shared	100	100	No	No	Yes	Yes	9	8
217	3x51	3x55	Shared	100	100	Yes	No	No	No	8	7
218	3x51	5x57	Shared	100	100	Yes	No	No	No	8	7
219	3x54	5x64	Shared	100	100	No	No	No	Yes	8	5
220	4x63	4x64	Shared	100	100	No	No	No	No	5	4
221	4x64	E2	Shared	100	100	No	No	Yes	Yes	4	3
222	4x65	E2x52	Shared	100	100	Yes	No	No	No	5	4
223	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
224	E2	E2x52	Shared	100	100	Yes	Yes	No	No	3	4
225	5x35	E2	Shared	100	100	Yes	No	Yes	Yes	3	3
226	5x36	E2	Shared	100	100	No	No	Yes	Yes	3	3
227	5x40	6x59	Shared	100	100	No	No	No	Yes	5	5
228	5x44	6x56	Shared	100	78.125	No	No	No	No	5	6
229	5x47	6x52	Shared	100	100	Yes	No	No	No	8	8
230	5x52	5x56	Shared	100	11.25	No	No	No	No	4	4
231	5x58	6x37	Shared	100	100	Yes	Yes	No	No	8	7
232	5x58	6x41	Shared	100	100	Yes	Yes	No	No	8	8
233	6x39	7x52	Shared	100	1.66667	No	No	No	No	5	8
234	6x40	7x52	Shared	100	100	No	No	No	No	8	8
235	6x44	6x48	Shared	100	100	Yes	No	Yes	Yes	9	9
236	6x47	7x45	Shared	100	100	No	No	Yes	No	8	9
237	6x48	7x41	Shared	100	100	Yes	Yes	No	No	9	8
238	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	9	9
239	6x51	6x55	Shared	100	100	Yes	Yes	No	No	6	6
240	6x51	7x38	Shared	100	100	Yes	Yes	No	No	6	5
241	7x38	7x42	Shared	100	100	No	No	Yes	Yes	5	7
242	7x38	Lig	Shared	100	100	No	No	Yes	Yes	5	0
243	Lig	Lig	Shared	100	100	Yes	Yes	Yes	Yes	0	0
244	E2	Lig	Shared	100	100	Yes	Yes	Yes	Yes	3	0
245	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
246	7x34	Lig	Shared	100	100	No	No	Yes	Yes	4	0
247	Lig	NT	Shared	100	100	Yes	Yes	Yes	Yes	0	0
248	NT	NT	Shared	100	100	Yes	Yes	Yes	Yes	0	0
249	1x35	7x35	Shared	100	50	Yes	Yes	Yes	No	6	4
250	4x48	4x52	Shared	100	6.25	No	No	No	No	4	4
251	4x60	5x39	Shared	100	56.25	No	No	No	No	7	5
252	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	4
253	6x57	E3	Shared	100	100	No	No	Yes	Yes	4	0
254	6x61	E3	Shared	100	100	No	No	Yes	Yes	4	0
255	3x47	5x54	Shared	100	100	No	No	No	No	9	8
256	2x50	3x39	Shared	100	100	Yes	Yes	No	No	9	9
257	5x54	6x44	Shared	100	100	No	No	Yes	No	8	9
258	6x50	7x37	Shared	62.5	50	No	No	No	No	9	7
259	1x43	2x57	Shared	62.5	66.25	Yes	No	No	No	7	7
260	5x47	6x49	Shared	75	100	Yes	No	No	No	8	5
261	2x46	7x49	Shared	37.5	100	No	No	No	No	9	9
262	6x38	6x42	Shared	50	0	No	No	No	No	4	5
263	3x44	5x50	Shared	25	50	No	No	No	Yes	8	8
264	3x49	I2x57	Shared	50	100	Yes	No	No	Yes	8	7
265	2x62	E1x52	Shared	50	20	Yes	No	Yes	Yes	4	7
266	1x45	7x47	Shared	25	30	No	No	No	No	6	8
267	2x37	2x40	Shared	50	100	No	No	Yes	No	7	8
268	3x44	5x53	Shared	16.6667	100	No	No	No	No	8	6
269	3x24	E1x52	Shared	12.5	100	No	No	Yes	Yes	5	7
270	6x32	6x36	Shared	50	1.66667	No	No	No	No	6	8
271	5x41	5x45	Shared	0	5	No	No	No	No	4	4
272	2x51	2x55	Shared	50	100	No	No	No	No	7	4
273	5x49	5x50	Shared	0	50	No	No	No	Yes	6	8
274	2x52	3x35	Shared	50	100	No	No	No	No	7	8
275	7x26	E3	Shared	50	50	No	Yes	Yes	Yes	1	0
276	1x60	8x53	Shared	50	50	Yes	Yes	No	No	5	5
277	3x48	5x57	Shared	25	5	No	No	No	No	6	7
278	1x31	1x35	Shared	12.5	30	No	No	Yes	Yes	3	6
279	1x57	2x44	Shared	50	100	No	No	No	No	7	6
280	3x34	4x54	Shared	0	31.25	No	No	No	Yes	6	4
281	2x40	I1x51	Shared	25	11.25	Yes	No	No	No	8	6
282	1x27	7x32	Shared	50	31.25	No	No	No	No	5	1
283	1x39	2x61	Shared	16.6667	100	Yes	Yes	No	No	7	7
284	1x43	1x47	Shared	50	50	Yes	No	No	No	7	6
285	3x51	5x60	Shared	50	100	Yes	No	Yes	No	8	4
286	3x27	3x31	Shared	12.5	3.33333	No	No	No	No	4	4
287	1x41	1x45	Shared	50	13.75	No	No	No	No	4	6
288	2x56	3x31	Shared	50	100	No	No	No	No	7	4
289	7x27	Lig	Shared	50	100	No	No	Yes	Yes	2	0
290	3x21	E1x50	Shared	0	0	No	No	Yes	Yes	7	8
291	5x63	5x67	Shared	0	50	No	No	No	No	4	5
292	7x24	NT	Shared	25	50	No	No	Yes	Yes	0	0
293	5x56	5x60	Shared	25	50	No	No	Yes	No	4	4
294	3x23	3x27	Shared	0	0	No	No	No	No	3	4
295	4x51	4x55	Shared	0	5	No	No	No	No	4	3
296	1x58	1x59	Shared	25	100	No	No	No	Yes	3	4
297	1x30	1x34	Shared	12.5	50	No	No	No	No	4	5
298	7x23	7x26	Shared	25	7.29167	No	No	No	Yes	0	1
299	4x41	4x44	Shared	0	6.25	No	Yes	No	No	4	3
300	7x56	8x47	Shared	12.5	50	Yes	No	No	No	6	8
301	4x46	4x47	Shared	0	0	No	No	No	No	7	4
302	4x54	4x55	Shared	0	0	No	Yes	No	No	4	3
303	5x62	6x38	Shared	0	15.4167	No	No	No	No	4	4
304	1x55	1x59	Shared	0	22.5	No	No	No	Yes	3	4
305	7x51	7x55	Shared	0	25	No	No	No	Yes	7	7
306	8x54	8x58	Shared	0	5	Yes	No	No	No	7	6
307	1x52	8x54	Shared	0	37.5	No	Yes	Yes	No	6	7
308	1x28	Lig	Shared	12.5	50	No	No	Yes	Yes	5	0
309	I2x52	I2x56	Shared	12.5	100	No	Yes	No	No	4	3
310	7x26	7x29	Shared	12.5	4.16667	No	Yes	No	No	1	3
311	I1x49	I1x50	Shared	4.16667	10	No	No	No	No	6	6
312	E2x51	Lig	protein_on	0	100	No	No	Yes	Yes	4	0
313	1x56	8x50	protein_on	0	100	No	No	No	Yes	7	8
314	2x39	3x49	protein_on	0	100	No	No	Yes	No	7	8
315	2x41	4x42	protein_on	0	100	No	No	No	No	7	7
316	2x42	4x42	protein_on	0	100	Yes	Yes	No	No	7	7
317	2x46	3x43	protein_on	0	100	No	No	No	No	9	8
318	2x53	3x32	protein_on	0	100	Yes	Yes	No	No	6	6
319	2x53	7x42	protein_on	0	100	Yes	Yes	Yes	Yes	6	7
320	E1x51	E1x52	protein_on	0	100	No	No	Yes	Yes	3	7
321	3x33	4x57	protein_on	0	100	No	No	No	No	5	7
322	3x34	4x57	protein_on	0	100	No	No	No	No	6	7
323	3x40	6x48	protein_on	0	100	No	No	Yes	Yes	8	9
324	3x43	7x53	protein_on	0	100	No	No	Yes	Yes	8	9
325	3x45	4x49	protein_on	0	100	No	No	No	No	6	7
326	3x46	7x53	protein_on	0	100	No	No	Yes	Yes	9	9
327	3x50	5x58	protein_on	0	100	Yes	No	Yes	Yes	9	8
328	3x50	7x53	protein_on	0	100	Yes	No	Yes	Yes	9	9
329	3x54	5x61	protein_on	0	100	No	No	No	No	8	8
330	3x56	I2x52	protein_on	0	100	No	No	No	Yes	6	4
331	5x39	E2	protein_on	0	100	No	No	Yes	Yes	5	3
332	5x62	6x37	protein_on	0	100	No	No	No	No	4	7
333	5x66	6x34	protein_on	0	100	No	No	No	No	4	6
334	6x40	7x53	protein_on	0	100	No	No	Yes	Yes	8	9
335	6x45	6x49	protein_on	0	100	No	No	No	No	5	5
336	6x51	6x52	protein_on	0	100	Yes	Yes	No	No	6	8
337	6x54	7x34	protein_on	0	100	No	No	No	No	5	4
338	7x49	7x50	protein_on	0	100	No	No	No	No	9	9
339	2x38	I2x57	protein_on	0	100	Yes	No	No	Yes	6	7
340	2x39	I2x57	protein_on	0	100	No	No	No	Yes	7	7
341	2x41	4x43	protein_on	0	100	No	No	No	No	7	4
342	2x46	2x50	protein_on	0	100	No	No	Yes	Yes	9	9
343	3x33	Lig	protein_on	0	100	No	No	Yes	Yes	5	0
344	3x53	I2x57	protein_on	0	100	No	No	No	Yes	8	7
345	3x55	5x64	protein_on	0	100	No	No	No	Yes	7	5
346	5x31	5x35	protein_on	0	100	No	No	Yes	No	0	3
347	5x44	6x52	protein_on	0	100	No	No	No	No	5	8
348	5x51	6x44	protein_on	0	100	No	No	Yes	No	6	9
349	5x55	6x41	protein_on	0	100	No	No	No	No	4	8
350	5x58	6x40	protein_on	0	100	Yes	Yes	No	No	8	8
351	5x62	6x34	protein_on	0	100	No	No	No	No	4	6
352	6x58	7x30	protein_on	0	100	No	No	No	No	4	4
353	6x58	Lig	protein_on	0	100	No	No	Yes	Yes	4	0
354	6x61	Lig	protein_on	0	100	No	No	Yes	Yes	4	0
355	7x56	8x48	protein_on	0	100	Yes	No	No	No	6	5
356	5x43	Lig	protein_on	0	100	No	No	Yes	Yes	5	0
357	E2x52	Lig	protein_on	0	100	No	No	Yes	Yes	4	0
358	5x33	6x59	protein_on	0	100	No	No	No	Yes	3	5
359	4x54	4x59	protein_on	0	100	No	Yes	No	No	4	5
360	6x31	6x35	protein_on	0	100	No	No	No	No	4	5
361	6x60	E3	protein_on	0	100	No	No	Yes	Yes	4	0
362	1x29	1x32	protein_on	0	100	No	No	No	No	4	7
363	7x30	Lig	protein_on	0	100	No	No	Yes	Yes	4	0
364	E1	Lig	protein_on	0	100	No	No	Yes	Yes	0	0
365	1x32	2x67	protein_on	0	100	No	No	No	No	7	0
366	1x56	8x52	protein_on	0	100	No	No	No	No	7	4
367	1x60	8x52	protein_on	0	100	Yes	Yes	No	No	5	4
368	8x48	I1	protein_on	0	100	No	No	No	No	5	0
369	2x63	E2	protein_on	0	50	No	No	Yes	Yes	4	3
370	2x43	7x54	protein_on	0	54.1667	No	No	No	No	8	7
371	5x36	6x59	protein_on	0	55	No	No	No	Yes	3	5
372	5x29	5x31	protein_on	0	50	No	No	No	No	0	0
373	3x36	Lig	protein_on	0	56.25	No	No	Yes	Yes	7	0
374	5x32	E2	protein_on	0	50	No	No	Yes	Yes	4	3
375	7x54	8x50	protein_on	0	50	No	No	No	Yes	7	8
376	1x35	7x36	protein_on	0	50	Yes	Yes	No	No	6	5
377	6x51	7x37	protein_on	0	50	Yes	Yes	No	No	6	7
378	2x49	3x38	protein_on	0	50	No	No	No	No	8	7
379	2x42	4x45	protein_on	0	50	Yes	Yes	No	No	7	5
380	1x54	2x51	protein_on	0	55	No	No	No	No	8	7
381	3x30	4x54	protein_on	0	50	No	No	No	Yes	6	4
382	7x31	Lig	protein_on	0	50	No	No	Yes	Yes	4	0
383	3x38	4x53	protein_on	0	30	No	No	No	No	7	8
384	6x36	7x55	protein_on	0	50	No	No	No	Yes	8	7
385	1x42	7x42	protein_on	0	55	No	No	Yes	Yes	7	7
386	4x39	4x43	protein_on	0	55	No	No	No	No	3	4
387	6x50	7x40	protein_on	0	50	No	No	No	No	9	7
388	3x47	5x57	protein_on	0	50	No	No	No	No	9	7
389	3x41	4x49	protein_on	0	50	No	No	No	No	5	7
390	1x57	2x40	protein_on	0	18.5417	No	No	Yes	No	7	8
391	8x47	8x50	protein_on	0	50	No	No	No	Yes	8	8
392	5x461	5x50	protein_on	0	11.6667	No	No	No	Yes	6	8
393	1x53	7x54	protein_on	0	25	Yes	No	No	No	9	7
394	8x51	8x54	protein_on	0	50	No	No	Yes	No	8	7
395	3x52	3x56	protein_on	0	59.375	No	No	No	No	5	6
396	2x54	7x46	protein_on	0	55	No	No	No	No	6	8
397	1x47	2x51	protein_on	0	13.75	No	No	No	No	6	7
398	1x34	1x38	protein_on	0	16.6667	No	No	No	No	5	5
399	5x37	5x41	protein_on	0	55	No	No	No	No	3	4
400	1x49	1x52	protein_on	0	50	No	No	No	Yes	7	6
401	I2x55	I2x56	protein_on	0	11.25	No	No	No	No	4	3
402	1x51	1x54	protein_on	0	50	No	No	No	No	4	8
403	5x37	6x59	protein_on	0	31.6667	No	No	No	Yes	3	5
404	1x59	8x57	protein_on	0	50	No	Yes	No	No	4	5
405	2x67	E2	protein_on	0	50	No	No	Yes	Yes	0	3
406	7x55	8x50	protein_on	0	50	No	Yes	No	Yes	7	8
407	1x42	7x47	protein_on	0	3.125	No	No	No	No	7	8
408	6x43	7x48	protein_on	0	50	No	No	No	No	6	6
409	3x53	I2x53	protein_on	0	50	No	No	No	No	8	5
410	3x55	3x56	protein_on	0	50	No	No	No	No	7	6
411	6x32	6x33	protein_on	0	50	No	No	No	No	6	7
412	5x61	5x65	protein_on	0	5	No	No	No	No	8	8
413	5x29	5x30	protein_on	0	50	No	No	No	No	0	0
414	4x40	4x44	protein_on	0	6.25	No	No	No	No	4	3
415	1x38	7x39	protein_on	0	25	No	No	No	No	5	5
416	2x37	I1	protein_on	0	50	No	No	No	No	7	0
417	1x31	7x32	protein_on	0	25	No	No	No	No	3	1
418	3x41	4x52	protein_on	0	12.9167	No	No	No	No	5	4
419	7x48	7x52	protein_on	0	11.25	No	No	No	No	6	8
420	2x55	2x56	protein_on	0	0	No	No	No	No	4	7
421	1x48	1x52	protein_on	0	50	No	No	No	Yes	4	6
422	5x45	5x48	protein_on	0	8.75	No	No	No	No	4	5
423	6x34	I3	protein_on	0	50	No	No	No	No	6	0
424	5x64	5x68	protein_on	0	50	No	Yes	No	No	5	0
425	1x37	1x41	protein_on	0	1.66667	No	No	No	No	5	4
426	2x48	2x52	protein_on	0	17.5	No	No	No	No	5	7
427	4x56	5x46	protein_on	0	17.5	No	No	No	No	5	4
428	2x64	E1	protein_on	0	0	No	No	No	No	5	0
429	6x54	7x33	protein_on	0	11.25	No	No	No	No	5	5
430	2x66	E1x51	protein_on	0	6.25	No	No	No	No	4	3
431	7x26	7x28	protein_on	0	0	No	Yes	No	No	1	3
432	6x62	Lig	protein_on	0	50	No	No	Yes	Yes	3	0
433	3x37	5x42	protein_on	0	50	Yes	No	No	No	7	4
434	3x26	4x62	protein_on	0	6.25	No	No	No	No	7	5
435	1x52	7x55	protein_on	0	25	No	Yes	No	Yes	6	7
436	5x31	5x34	protein_on	0	35	No	No	No	No	0	2
437	5x64	5x67	protein_on	0	1.66667	No	Yes	No	No	5	5
438	4x38	4x41	protein_on	0	5	No	No	No	Yes	7	4
439	1x60	8x55	protein_on	0	0	Yes	Yes	No	No	5	5
440	6x30	6x31	protein_on	0	17.5	No	No	No	No	5	4
441	I2x54	I2x55	protein_on	0	0	No	No	No	No	5	4
442	6x46	7x40	protein_on	0	0	No	No	No	No	6	7
443	1x36	2x64	protein_on	0	7.5	No	No	No	No	5	5
444	1x29	1x33	protein_on	0	11.25	No	No	No	No	4	5
445	2x65	2x66	protein_on	0	6.25	No	No	No	No	4	4
446	8x53	I1x48	protein_on	0	25	No	No	No	No	5	6
447	1x24	7x31	protein_on	0	30	No	No	No	No	0	4
448	6x64	E3	protein_on	0	16.25	No	No	Yes	Yes	1	0
449	1x54	1x58	protein_on	0	0	No	No	No	No	8	3
450	8x49	8x53	protein_on	0	8.125	No	No	No	No	6	5
451	5x68	6x30	protein_on	0	29.1667	No	No	No	No	0	5
452	5x37	6x63	protein_on	0	26.6667	No	No	No	No	3	1
453	4x41	4x45	protein_on	0	25	No	Yes	No	No	4	5
454	1x44	1x45	protein_on	0	5	No	No	No	No	6	6
455	I2x51	I2x52	protein_on	0	25	No	No	No	Yes	5	4
456	6x53	6x57	protein_on	0	0	No	No	No	No	6	4
457	6x29	I3	protein_on	0	25	No	No	No	No	4	0
458	7x25	7x29	protein_on	0	11.25	No	No	No	No	0	3
459	1x40	1x41	protein_on	0	0	No	No	No	No	3	4
460	5x38	5x39	protein_on	0	0	No	No	No	No	4	5
461	8x60	8x61	protein_on	0	17.5	No	No	No	No	0	0
462	1x60	I1x49	protein_on	0	12.5	Yes	Yes	No	No	5	6
463	1x26	1x29	protein_on	0	2.5	No	No	No	No	0	4
464	6x27	6x30	protein_on	0	10	No	No	No	No	1	5
465	1x59	8x60	protein_on	0	5	No	Yes	No	No	4	0
466	5x55	5x59	protein_on	0	0	No	No	No	No	4	4
467	8x56	8x60	protein_on	0	5	No	No	No	No	4	0
468	6x26	6x29	protein_on	0	5	No	No	No	No	0	4
469	2x38	I2	protein_on	0	5	Yes	No	No	No	6	0
470	6x28	6x29	protein_on	0	7.5	No	No	No	No	3	4
471	1x25	1x28	protein_on	0	10	No	No	No	No	0	5
472	6x65	7x30	protein_on	0	5	No	No	No	No	0	4
473	I2x52	I2x58	protein_on	0	6.25	No	Yes	No	No	4	0
474	CT	I1x48	protein_on	0	0	No	No	No	No	4	6
475	8x58	8x59	protein_on	0	3.125	No	No	No	No	6	0
476	4x41	I2x59	protein_on	0	0	No	Yes	No	No	4	0

Orange: nodes, hubs and links specific of protein_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of protein_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	protein_off Avg Int. Strength	protein_on Avg Int. Strength	protein_off Num Of Links	protein_on Num Of Links	ConSurf
1	1x43	protein_off	0	0	4	3	7
2	1x50	protein_off	0	0	4	2	9
3	1x53	protein_off	50	0	4	2	9
4	2x38	protein_off	0	0	4	3	6
5	2x40	protein_off	0	0	4	3	8
6	2x62	protein_off	0	0	4	1	4
7	3x37	protein_off	87.5	27.5	6	3	7
8	3x42	protein_off	0	0	4	2	7
9	3x49	protein_off	50	57.5	5	3	8
10	3x50	protein_off	50	0	6	2	9
11	3x51	protein_off	20.8333	21.875	4	3	8
12	4x50	protein_off	0	0	6	2	9
13	4x65	protein_off	50	0	4	2	5
14	5x35	protein_off	0	0	4	2	3
15	5x47	protein_off	0	0	4	2	8
16	5x60	protein_off	0	0	4	2	4
17	6x44	protein_off	50	50	4	3	9
18	7x35	protein_off	50	0	4	1	4
19	7x45	protein_off	50	0	5	2	9
20	7x56	protein_off	0	0	4	2	6
21	8x54	protein_off	0	0	4	3	7
22	1x35	Shared	0	0	6	4	6
23	1x39	Shared	33.3333	12.5	4	4	7
24	1x60	Shared	0	0	7	4	5
25	2x42	Shared	0	93.75	5	6	7
26	2x50	Shared	50	50	4	4	9
27	2x53	Shared	62.5	65.8333	5	4	6
28	E1x50	Shared	100	93.75	7	5	8
29	E1x52	Shared	0	12.5	4	5	7
30	E2	Shared	100	100	13	14	3
31	5x58	Shared	50	100	5	5	8
32	6x48	Shared	100	93.75	6	5	9
33	6x51	Shared	50	50	4	5	6
34	7x42	Shared	37.5	91.25	4	5	7
35	7x53	Shared	50	97.5	9	5	9
36	Lig	Shared	100	100	15	22	0
37	NT	Shared	50	41.875	12	4	0
38	E3	Shared	62.5	12.5	10	5	0
39	1x52	protein_on	0	0	1	4	6
40	1x59	protein_on	0	0	3	4	4
41	I2x52	protein_on	0	0	2	4	4
42	4x41	protein_on	0	0	3	4	4
43	4x54	protein_on	0	0	2	4	4
44	5x50	protein_on	0	0	3	4	8
45	5x64	protein_on	0	0	1	4	5
46	6x59	protein_on	0	0	2	4	5
47	7x26	protein_on	0	0	3	4	1
48	7x55	protein_on	0	0	2	4	7
49	8x50	protein_on	0	32.0833	1	4	8
50	I2x57	protein_on	0	50	2	4	7

Orange: nodes, hubs and links specific of protein_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of protein_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	protein_off Recurrence	protein_on Recurrence	protein_off Hub1?	protein_on Hub1?	protein_off Hub2?	protein_on Hub2?	ConSurf1	ConSurf2
1	2x54	2x57	protein_off	17.2682	0	No	No	No	No	6	7
2	1x46	2x54	protein_off	15.1241	1.19243	No	No	No	No	8	6
3	7x35	Lig	protein_off	13.041	0	Yes	No	Yes	Yes	4	0
4	6x48	6x51	protein_off	100	0	Yes	Yes	Yes	Yes	9	6
5	2x53	6x48	protein_off	54.4174	0	Yes	Yes	Yes	Yes	6	9
6	2x53	7x46	protein_off	33.2815	3.56465	Yes	Yes	No	No	6	8
7	2x50	7x46	protein_off	74.0126	0	Yes	Yes	No	No	9	8
8	1x50	2x50	protein_off	87.0956	1.5878	Yes	No	Yes	Yes	9	9
9	6x48	7x45	protein_off	27.5366	2.30579	Yes	Yes	Yes	No	9	9
10	7x45	7x46	protein_off	41.3028	0	Yes	No	No	No	9	8
11	2x53	3x39	protein_off	33.4118	0	Yes	Yes	No	No	6	9
12	2x50	3x39	protein_off	33.168	1.5878	Yes	Yes	No	No	9	9
13	1x50	7x50	protein_off	41.5236	0.00948887	Yes	No	No	No	9	9
14	1x53	7x50	protein_off	40.4536	0	Yes	No	No	No	9	9
15	1x50	2x47	protein_off	42.6839	0	Yes	No	No	No	9	9
16	1x53	2x47	protein_off	40.544	1.58464	Yes	No	No	No	9	9
17	1x53	7x53	protein_off	71.0886	0	Yes	No	Yes	Yes	9	9
18	1x60	7x53	protein_off	27.9276	0	Yes	Yes	Yes	Yes	5	9
19	1x56	1x60	protein_off	11.2438	0	No	No	Yes	Yes	7	5
20	3x50	6x37	protein_off	13.4782	0	Yes	No	No	No	9	7
21	3x49	3x50	protein_off	10.0099	0	Yes	No	Yes	No	8	9
22	2x50	7x49	protein_off	27.4988	0.0126518	Yes	Yes	No	No	9	9
23	2x46	7x49	protein_off	22.4035	3.14714	No	No	No	No	9	9
24	2x46	3x42	protein_off	21.1191	0	No	No	Yes	No	9	7
25	3x42	4x50	protein_off	14.565	0	Yes	No	Yes	No	7	9
26	E1x50	E2	protein_off	15.3469	0	Yes	Yes	Yes	Yes	8	3
27	3x36	5x43	protein_off	18.2057	0	No	No	No	No	7	5
28	3x37	5x43	protein_off	17.3964	4.58945	Yes	No	No	No	7	5
29	Lig	NT	protein_off	21.672	1.72065	Yes	Yes	Yes	Yes	0	0
30	3x40	6x44	protein_off	13.8713	0	No	No	Yes	No	8	9
31	3x40	5x50	protein_off	13.2134	5.72179	No	No	No	Yes	8	8
32	3x44	5x50	protein_off	10.5396	2.30579	No	No	No	Yes	8	8
33	3x37	5x461	protein_off	10.1759	0	Yes	No	No	No	7	6
34	6x36	7x53	protein_off	20.9447	0	No	No	Yes	Yes	8	9
35	6x36	7x56	protein_off	11.2438	0	No	No	Yes	No	8	6
36	E3	NT	protein_off	12.753	0	Yes	Yes	Yes	Yes	0	0
37	1x46	7x47	protein_off	12.9758	0	No	No	No	No	8	8
38	2x40	7x53	protein_off	12.1224	0	Yes	No	Yes	Yes	8	9
39	6x51	7x38	protein_off	17.8925	1.8187	Yes	Yes	No	No	6	5
40	7x42	Lig	protein_off	19.8348	0	Yes	Yes	Yes	Yes	7	0
41	6x44	7x45	protein_off	14.4704	0	Yes	No	Yes	No	9	9
42	2x53	3x36	protein_off	12.2086	0	Yes	Yes	No	No	6	7
43	2x57	7x42	Shared	31.6125	19.7621	No	No	Yes	Yes	7	7
44	1x43	2x57	Shared	12.7698	18.7152	Yes	No	No	No	7	7
45	6x51	Lig	Shared	80.6718	11.7915	Yes	Yes	Yes	Yes	6	0
46	6x44	6x48	Shared	21.0519	99.4844	Yes	No	Yes	Yes	9	9
47	5x54	6x44	Shared	24.9574	99.5951	No	No	Yes	No	8	9
48	3x47	5x54	Shared	24.0809	99.8166	No	No	No	No	9	8
49	3x47	5x58	Shared	23.5196	100	No	No	Yes	Yes	9	8
50	5x58	6x37	Shared	13.9155	10.4536	Yes	Yes	No	No	8	7
51	E2	Lig	Shared	24.6526	38.2718	Yes	Yes	Yes	Yes	3	0
52	7x38	7x42	Shared	17.0096	39.2175	No	No	Yes	Yes	5	7
53	1x39	7x42	protein_on	4.16413	13.2591	Yes	Yes	Yes	Yes	7	7
54	7x38	Lig	protein_on	0.0903874	38.1326	No	No	Yes	Yes	5	0
55	3x43	7x53	protein_on	0	10.8995	No	No	Yes	Yes	8	9
56	3x50	7x53	protein_on	0	47.3083	Yes	No	Yes	Yes	9	9
57	3x50	5x58	protein_on	0	47.6468	Yes	No	Yes	Yes	9	8
58	3x36	6x48	protein_on	6.86734	98.1244	No	No	Yes	Yes	7	9
59	3x36	Lig	protein_on	0	97.827	No	No	Yes	Yes	7	0
60	6x40	7x53	protein_on	0	48.3742	No	No	Yes	Yes	8	9
61	5x58	6x40	protein_on	0	50.4143	Yes	Yes	No	No	8	8
62	7x56	8x48	protein_on	0	10.191	Yes	No	No	No	6	5
63	7x56	8x47	protein_on	1.61226	11.7346	Yes	No	No	No	6	8
64	8x47	8x50	protein_on	0	13.2718	No	No	No	Yes	8	8
65	7x54	8x50	protein_on	0	43.6962	No	No	No	Yes	7	8
66	2x43	7x54	protein_on	0	47.8492	No	No	No	No	8	7
67	2x43	7x53	protein_on	1.99903	48.8803	No	No	Yes	Yes	8	9
68	2x42	3x46	protein_on	0.731507	43.2218	Yes	Yes	No	No	7	9
69	3x46	7x53	protein_on	0	44.5407	No	No	Yes	Yes	9	9
70	2x42	3x45	protein_on	2.66538	14.0435	Yes	Yes	No	No	7	6
71	3x45	4x49	protein_on	0	12.5221	No	No	No	No	6	7
72	1x47	2x51	protein_on	0	15.5364	No	No	No	No	6	7
73	1x43	1x47	protein_on	4.34911	16.6024	Yes	No	No	No	7	6
74	2x63	E1x50	protein_on	0.704181	13.471	No	No	Yes	Yes	4	8
75	2x63	E2	protein_on	0	14.2649	No	No	Yes	Yes	4	3
76	3x34	4x57	protein_on	0	13.471	No	No	No	No	6	7
77	3x33	4x57	protein_on	0	14.5528	No	No	No	No	5	7
78	3x33	Lig	protein_on	0	16.5707	No	No	Yes	Yes	5	0
79	3x51	5x57	protein_on	6.24514	24.8577	Yes	No	No	No	8	7
80	3x47	5x57	protein_on	0	26.863	No	No	No	No	9	7
81	3x51	3x55	protein_on	0.739915	20.7711	Yes	No	No	No	8	7
82	3x55	5x64	protein_on	0	11.4341	No	No	No	Yes	7	5
83	6x61	E3	protein_on	0.655834	10.4725	No	No	Yes	Yes	4	0
84	6x61	Lig	protein_on	0	11.2918	No	No	Yes	Yes	4	0
85	1x56	8x52	protein_on	0	12.5854	No	No	No	No	7	4
86	1x56	8x50	protein_on	0	13.7747	No	No	No	Yes	7	8
87	1x60	8x52	protein_on	0	11.0387	Yes	Yes	No	No	5	4
88	7x55	8x50	protein_on	0	17.352	No	Yes	No	Yes	7	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x35	1x39	Shared	5.22667	5.54858	0	0	2	2
1x39	7x39	Shared	4.21583	3.05517	0	0	2	2
1x39	7x42	Shared	4.02333	5.28396	0	0	2	1
2x53	3x36	protein_off	3.77625	0	1	0	2	1
2x53	6x48	protein_off	4.0225	0	1	0	2	2
2x56	2x60	protein_off	5.07083	0	0	0	2	1
2x57	7x42	Shared	9.46917	5.62452	0	0	2	1
2x60	3x32	Shared	7.45917	3.86419	1	1	1	1
2x60	Lig	Shared	14.3146	7.74442	1	1	1	0
2x63	E1x50	Shared	7.21292	8.84429	0	1	2	2
E1x49	E2	Shared	10.6033	5.46679	1	0	2	1
E1x50	E2	protein_off	4.78542	0	1	1	2	1
3x22	E2	Shared	8.4275	4.51406	1	0	2	1
3x32	Lig	Shared	6.61208	7.17352	1	1	1	0
3x33	3x37	protein_off	3.79333	0	0	1	1	2
3x33	4x61	Shared	16.0921	3.55254	0	1	1	2
3x36	5x43	protein_off	4.21833	0	1	1	1	1
3x36	6x48	Shared	5.32875	5.77423	1	1	1	2
3x37	5x43	Shared	4.06583	5.35277	0	0	2	1
4x61	5x39	protein_off	7.90625	0	0	0	2	2
4x64	E2	Shared	12.6221	15.1717	1	1	2	1
4x64	5x35	protein_off	4.50958	0	1	1	2	2
4x65	E2x52	Shared	6.38625	7.1676	1	0	2	1
E2	E2	Shared	44.1237	48.5229	1	1	1	1
E2	E2x52	Shared	5.3575	8.48423	1	1	1	1
5x35	E2	Shared	7.40542	6.48019	1	1	2	1
5x36	E2	Shared	6.62208	10.728	0	1	2	1
5x44	6x56	Shared	6.83083	3.62723	1	0	1	2
6x48	6x51	protein_off	6.15042	0	1	0	2	1
6x51	6x55	Shared	4.46958	9.343	1	1	1	2
6x51	7x38	Shared	5.38958	4.28006	1	1	1	1
7x35	Lig	protein_off	6.01833	0	1	0	1	0
7x38	7x42	Shared	5.98958	3.9476	1	1	1	1
7x38	Lig	Shared	5.66583	5.49763	1	1	1	0
7x42	Lig	protein_off	4.5875	0	1	0	1	0
E2	Lig	Shared	13.9296	24.2765	1	1	1	0
6x51	Lig	Shared	16.2238	4.73475	1	1	1	0
7x34	Lig	Shared	7.16792	4.47827	0	1	1	0
Lig	NT	Shared	20.8229	22.5792	1	1	0	1
NT	NT	Shared	7.20583	8.99115	1	1	1	1
1x35	7x35	Shared	8.3575	3.48935	0	0	2	1
E2	E2x51	Shared	11.1112	9.89754	1	1	1	1
6x61	E3	Shared	6.76458	5.1294	0	1	1	2
7x35	7x39	protein_off	7.13875	0	1	0	1	2
4x61	4x65	protein_off	5.19375	0	0	0	2	2
6x58	E3	protein_off	8.36375	0	1	1	1	2
E3	E3	protein_off	5.76042	0	1	0	2	2
5x44	Lig	protein_off	5.61	0	1	0	1	0
6x54	Lig	protein_off	4.605	0	1	0	1	0
E3	NT	protein_off	6.82	0	1	0	2	1
E2	NT	protein_off	7.155	0	1	1	1	1
5x40	NT	protein_off	4.25	0	1	0	2	1
6x58	NT	protein_off	4.87	0	1	1	1	1
3x32	NT	protein_off	5.655	0	1	1	1	1
4x65	NT	protein_off	5.545	0	1	0	2	1
2x64	E1x50	protein_off	4.52	0	0	0	2	2
7x30	7x33	protein_off	4.04	0	0	1	1	2
6x54	7x37	protein_off	3.61	0	1	0	1	2
5x32	5x35	protein_off	3.59625	0	0	0	2	2
1x35	7x31	protein_off	3.575	0	0	0	2	1
7x30	7x32	protein_off	3.565	0	0	1	1	2
7x33	E3	protein_off	2.98	0	1	0	2	2
E1	NT	protein_off	2.875	0	0	1	1	1
1x42	7x39	protein_off	2.77	0	0	0	2	2
6x62	E3	protein_off	2.5375	0	1	0	1	2
1x38	7x35	protein_off	2.075	0	0	0	2	1
7x27	Lig	Shared	1.80083	4.25406	0	0	1	0
6x62	6x63	protein_off	1.60375	0	1	0	1	2
7x24	NT	Shared	1.51667	2.88546	0	0	2	1
1x33	NT	protein_off	1.41	0	0	0	2	1
5x31	E2	protein_off	1.1175	0	0	0	2	1
1x28	Lig	Shared	0.52875	1.70425	0	1	1	0
6x65	E3	protein_off	0.2125	0	0	0	2	2
E2x51	Lig	protein_on	0	18.3904	0	1	1	0
2x53	3x32	protein_on	0	7.84383	1	0	2	1
2x53	7x42	protein_on	0	5.42146	1	0	2	1
3x33	4x57	protein_on	0	4.52921	0	1	1	2
5x39	E2	protein_on	0	6.31419	0	1	2	1
6x51	6x52	protein_on	0	4.9424	1	1	1	2
6x54	7x34	protein_on	0	6.50406	1	0	1	1
3x33	Lig	protein_on	0	4.83767	0	1	1	0
5x31	5x35	protein_on	0	4.33187	0	0	2	2
5x44	6x52	protein_on	0	5.68342	1	0	1	2
6x58	7x30	protein_on	0	4.80021	1	1	1	1
6x58	Lig	protein_on	0	9.54669	1	1	1	0
6x61	Lig	protein_on	0	8.1065	0	1	1	0
5x43	Lig	protein_on	0	5.47081	0	1	1	0
E2x52	Lig	protein_on	0	4.53075	1	1	1	0
7x30	Lig	protein_on	0	6.76594	0	1	1	0
E1	Lig	protein_on	0	4.64	0	1	1	0
2x63	E2	protein_on	0	3.74121	0	1	2	1
3x36	Lig	protein_on	0	3.62312	1	1	1	0
5x32	E2	protein_on	0	3.58335	0	0	2	1
6x51	7x37	protein_on	0	3.42525	1	1	1	2
7x31	Lig	protein_on	0	3.20721	0	1	1	0
1x42	7x42	protein_on	0	3.1351	0	0	2	1
2x67	E2	protein_on	0	2.765	0	1	2	1
1x38	7x39	protein_on	0	2.37038	0	0	2	2
2x64	E1	protein_on	0	2	0	0	2	1
6x54	7x33	protein_on	0	1.97054	1	0	1	2
6x62	Lig	protein_on	0	1.74227	1	0	1	0
1x24	7x31	protein_on	0	1.29875	0	0	2	1
1x25	1x28	protein_on	0	0.371	0	0	2	1
6x65	7x30	protein_on	0	0.3655	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	protein_off	chemokine_off grh_off
	protein_on	chemokine_on chemerin_on

Network Difference
Value	protein_off	protein_on
I_min	3.76958	3.74181
Number of Linked Nodes	286	289
Number of Specific Nodes	4 (1.40%)	7 (2.42%)
Number of Shared Nodes	282 (98.60%)	282 (97.58%)
Number of Links	311	303
Number of Specific Links	173 (55.63%)	165 (54.46%)
Number of Shared Links	138 (44.37%)	138 (45.54%)
Number of Hubs	38	29
Number of Specific Hubs	21 (55.26%)	12 (41.38%)
Number of Shared Hubs	17 (44.74%)	17 (58.62%)
Average % Shared Neighbours (Jaccard)	32.17
Average % Shared Neighbours (Otsuka)	40.85
Average % Shared Neighbours (Overlap Coefficient)	49.72
Average % Shared Cliques (k3-6)	79.17
Graphlets Similarity	0.4618

Paths Difference
Value	protein_off	protein_on
Number Of Nodes in MetaPath	48	46
Specific Nodes in MetaPath	27 (56.25%)	25 (54.35%)
Shared Nodes in MetaPath	282 (98.60%)	282 (98.60%)
Number Of Links MetaPath	52	46
Specific Links in MetaPath	42 (80.77%)	36 (78.26%)
Shared Links in MetaPath	138 (44.37%)	138 (44.37%)
Number of Shortest Paths	78043	54583
Length Of Smallest Path	3	3
Average Path Length	13.4645	13.9447
Length of Longest Path	23	31
Minimum Path Strength	0.96125	0.589625
Average Path Strength	6.03564	5.79328
Maximum Path Strength	14.399	20.6758
Minimum Path Correlation	0.700417	0.70125
Average Path Correlation	0.898037	0.918053
Maximum Path Correlation	0.98375	0.987521
Minimum % Of Corr. Nodes	4.7619	3.57143
Average % Of Corr. Nodes	37.3169	40.4032
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	53.2643	33.3544
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download protein_off_on.zip<

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