psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Orange: nodes, hubs and links specific of protein_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of protein_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	protein_off Int. Strength	protein_on Int. Strength	protein_off Hub1?	protein_on Hub1?	protein_off Hub2?	protein_on Hub2?	ConSurf1	ConSurf2
1	1x31	1x35	protein_off	100	0	No	No	Yes	No	5	6
2	1x42	7x43	protein_off	100	0	No	No	No	No	7	5
3	1x53	7x50	protein_off	100	0	Yes	No	No	No	8	9
4	1x53	7x53	protein_off	100	0	Yes	No	Yes	Yes	8	9
5	1x56	1x60	protein_off	100	0	No	No	Yes	No	7	5
6	2x38	3x49	protein_off	100	0	Yes	No	Yes	No	6	8
7	2x39	3x50	protein_off	100	0	No	No	Yes	No	8	9
8	2x60	3x32	protein_off	100	0	No	No	Yes	Yes	7	7
9	2x63	Lig	protein_off	100	0	No	No	Yes	Yes	4	0
10	E1x49	E1x51	protein_off	100	0	No	No	No	No	3	3
11	E1x50	E2	protein_off	100	0	Yes	Yes	Yes	Yes	9	3
12	3x37	3x41	protein_off	100	0	Yes	Yes	Yes	No	7	5
13	3x37	5x46	protein_off	100	0	Yes	Yes	No	No	7	4
14	3x40	6x44	protein_off	100	0	No	No	Yes	No	7	9
15	3x43	6x41	protein_off	100	0	No	No	No	No	8	8
16	3x43	6x44	protein_off	100	0	No	No	Yes	No	8	9
17	3x49	3x50	protein_off	100	0	Yes	No	Yes	No	8	9
18	3x50	6x33	protein_off	100	0	Yes	No	No	No	9	8
19	3x50	6x37	protein_off	100	0	Yes	No	No	No	9	8
20	3x51	3x56	protein_off	100	0	Yes	No	No	Yes	8	6
21	4x48	4x52	protein_off	100	0	No	No	No	No	3	4
22	4x61	5x39	protein_off	100	0	No	No	No	No	4	5
23	5x32	Lig	protein_off	100	0	No	No	Yes	Yes	3	0
24	5x34	5x35	protein_off	100	0	No	No	Yes	No	1	3
25	6x35	7x56	protein_off	100	0	No	No	Yes	No	5	7
26	6x44	7x45	protein_off	100	0	Yes	No	Yes	No	9	9
27	6x48	6x51	protein_off	100	0	Yes	Yes	Yes	No	9	7
28	6x50	7x37	protein_off	100	0	No	No	Yes	No	9	7
29	6x51	Lig	protein_off	100	0	Yes	No	Yes	Yes	7	0
30	7x35	7x39	protein_off	100	0	No	No	No	No	3	6
31	7x35	Lig	protein_off	100	0	No	No	Yes	Yes	3	0
32	5x32	5x35	protein_off	100	0	No	No	Yes	No	3	3
33	7x38	7x42	protein_off	100	0	No	No	Yes	Yes	6	8
34	7x45	7x46	protein_off	100	0	Yes	No	No	No	9	8
35	1x30	7x32	protein_off	100	0	No	No	No	No	2	1
36	3x32	3x36	protein_off	100	0	Yes	Yes	No	No	7	7
37	3x41	5x50	protein_off	100	0	Yes	No	Yes	No	5	9
38	4x38	4x42	protein_off	100	0	No	No	No	No	6	7
39	4x56	5x42	protein_off	100	0	No	No	No	No	5	3
40	4x61	E2x52	protein_off	100	0	No	No	No	No	4	4
41	E3	NT	protein_off	100	0	Yes	Yes	Yes	Yes	4	4
42	3x54	5x60	protein_off	100	0	No	No	No	No	8	4
43	5x32	5x34	protein_off	100	0	No	No	No	No	3	1
44	6x58	E3	protein_off	100	0	No	No	Yes	Yes	4	4
45	3x45	4x49	protein_off	66.6667	0	Yes	No	No	No	6	6
46	6x36	7x53	protein_off	66.6667	0	No	No	Yes	Yes	8	9
47	5x44	Lig	protein_off	33.3333	0	No	No	Yes	Yes	5	0
48	3x39	7x45	protein_off	50	0	No	No	Yes	No	9	9
49	3x43	6x40	protein_off	33.3333	0	No	No	No	No	8	8
50	7x36	7x37	protein_off	33.3333	0	No	No	Yes	No	5	7
51	3x45	4x45	protein_off	33.3333	0	Yes	No	No	No	6	6
52	5x58	6x38	protein_off	66.6667	0	No	Yes	No	No	9	5
53	1x27	7x32	protein_off	50	0	No	No	No	No	1	1
54	3x54	5x64	protein_off	33.3333	0	No	No	No	No	8	5
55	1x53	1x57	protein_off	33.3333	0	Yes	No	No	No	8	7
56	1x27	7x31	protein_off	33.3333	0	No	No	No	No	1	4
57	7x53	7x57	protein_off	33.3333	0	Yes	Yes	No	No	9	0
58	5x34	5x38	protein_off	50	0	No	No	No	No	1	3
59	7x55	7x56	protein_off	33.3333	0	No	No	Yes	No	7	7
60	6x59	6x60	protein_off	33.3333	0	No	No	No	No	5	5
61	7x33	7x37	protein_off	33.3333	0	No	No	Yes	No	6	7
62	5x52	5x56	protein_off	50	0	No	No	No	No	4	4
63	1x50	2x51	protein_off	33.3333	0	No	No	No	No	9	7
64	1x25	NT	protein_off	33.3333	0	No	No	Yes	Yes	3	4
65	1x54	2x47	protein_off	0	0	No	No	No	No	7	9
66	5x68	6x26	protein_off	33.3333	0	No	No	No	No	0	0
67	6x54	Lig	protein_off	33.3333	0	No	Yes	Yes	Yes	5	0
68	2x52	3x31	protein_off	33.3333	0	No	No	Yes	No	7	5
69	2x64	E1x50	protein_off	33.3333	0	No	No	Yes	Yes	5	9
70	6x44	6x45	protein_off	50	0	Yes	No	No	No	9	5
71	2x54	2x57	protein_off	33.3333	0	No	No	No	No	6	7
72	3x48	5x53	protein_off	33.3333	0	No	No	No	No	7	6
73	3x24	E1x52	protein_off	0	0	No	No	Yes	Yes	6	7
74	6x29	6x32	protein_off	33.3333	0	No	No	No	No	6	7
75	2x38	4x42	protein_off	33.3333	0	Yes	No	No	No	6	7
76	3x33	4x57	protein_off	33.3333	0	No	No	No	No	5	7
77	3x50	6x30	protein_off	33.3333	0	Yes	No	No	No	9	7
78	5x58	5x62	protein_off	33.3333	0	No	Yes	No	Yes	9	4
79	2x38	4x41	protein_off	33.3333	0	Yes	No	No	Yes	6	3
80	5x31	E2	protein_off	33.3333	0	No	No	Yes	Yes	3	3
81	7x28	7x29	protein_off	33.3333	0	No	No	No	No	1	2
82	6x29	6x33	protein_off	33.3333	0	No	No	No	No	6	8
83	5x41	6x59	protein_off	33.3333	0	No	No	No	No	4	5
84	4x40	4x43	protein_off	33.3333	0	No	No	No	No	4	4
85	7x30	7x33	protein_off	33.3333	0	No	No	No	No	5	6
86	7x43	7x47	protein_off	33.3333	0	No	No	No	No	5	8
87	6x47	7x48	protein_off	33.3333	0	No	No	No	No	8	6
88	8x57	CT	protein_off	33.3333	0	No	No	No	No	4	4
89	1x60	CT	protein_off	33.3333	0	Yes	No	No	No	5	4
90	5x63	5x67	protein_off	33.3333	0	No	No	No	No	3	5
91	6x38	6x42	protein_off	33.3333	0	No	No	No	No	5	5
92	1x26	7x25	protein_off	33.3333	0	No	No	No	No	1	1
93	1x33	1x36	protein_off	33.3333	0	No	No	No	No	3	6
94	1x40	2x62	protein_off	33.3333	0	No	No	No	No	3	5
95	6x43	7x45	protein_off	33.3333	0	No	No	Yes	No	6	9
96	1x45	1x49	protein_off	33.3333	0	Yes	No	No	No	5	8
97	7x36	7x40	protein_off	33.3333	0	No	No	No	No	5	8
98	5x61	6x34	protein_off	33.3333	0	No	No	No	No	8	6
99	1x38	7x40	protein_off	33.3333	0	No	No	No	No	6	8
100	1x41	1x45	protein_off	33.3333	0	No	No	Yes	No	5	5
101	5x51	5x55	protein_off	33.3333	0	No	No	No	No	6	4
102	8x53	I1x48	protein_off	33.3333	0	No	No	No	No	5	5
103	1x59	I1	protein_off	33.3333	0	No	No	No	Yes	4	0
104	6x62	E3	protein_off	33.3333	0	No	No	Yes	Yes	3	4
105	5x33	5x36	protein_off	0	0	No	No	No	No	2	4
106	I2x54	I2x55	protein_off	33.3333	0	No	No	No	No	4	3
107	8x49	8x50	protein_off	33.3333	0	No	No	No	Yes	6	8
108	3x45	4x40	protein_off	33.3333	0	Yes	No	No	No	6	4
109	5x33	5x37	protein_off	33.3333	0	No	No	No	No	2	3
110	6x63	6x64	protein_off	33.3333	0	No	No	No	No	1	1
111	6x32	8x48	protein_off	33.3333	0	No	No	No	No	7	5
112	1x60	7x53	protein_off	33.3333	0	Yes	No	Yes	Yes	5	9
113	1x30	1x34	protein_off	33.3333	0	No	No	No	No	2	6
114	2x551	3x31	protein_off	33.3333	0	No	No	Yes	No	0	5
115	6x26	6x31	protein_off	33.3333	0	No	No	No	No	0	5
116	3x41	4x52	protein_off	16.6667	0	Yes	No	No	No	5	4
117	2x51	2x55	protein_off	33.3333	0	No	No	No	No	7	5
118	5x65	5x69	protein_off	33.3333	0	No	No	No	No	8	0
119	2x66	E1x51	protein_off	33.3333	0	No	No	No	No	4	3
120	6x46	6x47	protein_off	16.6667	0	No	No	No	No	5	8
121	3x41	4x53	protein_off	0	0	Yes	No	No	No	5	7
122	5x65	6x31	protein_off	16.6667	0	No	No	No	No	8	5
123	3x51	3x52	protein_off	33.3333	0	Yes	No	No	No	8	5
124	7x53	8x50	protein_off	33.3333	0	Yes	Yes	No	Yes	9	8
125	6x26	6x27	protein_off	33.3333	0	No	No	No	No	0	0
126	4x39	I2x55	protein_off	33.3333	0	No	No	No	No	2	3
127	3x52	I2x56	protein_off	0	0	No	No	No	No	5	4
128	1x51	2x51	protein_off	16.6667	0	No	No	No	No	3	7
129	4x40	4x44	protein_off	33.3333	0	No	No	No	No	4	1
130	7x53	7x54	protein_off	33.3333	0	Yes	Yes	No	No	9	7
131	1x43	1x44	protein_off	0	0	No	No	No	No	7	5
132	4x51	4x55	protein_off	0	0	No	No	No	No	4	4
133	2x44	I1x50	protein_off	33.3333	0	No	No	No	No	6	6
134	3x23	3x27	protein_off	0	0	No	No	No	No	3	5
135	1x33	1x37	protein_off	0	0	No	No	No	No	3	5
136	I1x49	I1x51	protein_off	16.6667	0	No	No	No	No	5	7
137	6x57	6x64	protein_off	16.6667	0	No	No	No	No	4	1
138	3x51	5x56	protein_off	16.6667	0	Yes	No	No	No	8	4
139	1x58	1x59	protein_off	16.6667	0	No	No	No	No	3	4
140	4x51	4x52	protein_off	0	0	No	No	No	No	4	4
141	1x45	7x51	protein_off	0	0	Yes	No	No	No	5	6
142	1x32	1x35	protein_off	0	0	No	No	Yes	No	4	6
143	6x27	6x28	protein_off	0	0	No	No	No	No	0	5
144	8x55	8x59	protein_off	16.6667	0	No	No	No	No	4	3
145	1x28	E2	protein_off	16.6667	0	No	No	Yes	Yes	1	3
146	6x49	6x53	protein_off	0	0	No	No	No	No	6	6
147	4x46	4x47	protein_off	0	0	No	No	No	No	7	4
148	8x57	8x58	protein_off	0	0	No	No	No	No	4	5
149	6x32	I2x50	protein_off	0	0	No	No	No	No	7	7
150	1x29	1x31	protein_off	0	0	No	No	No	No	2	5
151	1x48	1x52	protein_off	0	0	No	No	No	No	3	6
152	8x56	8x59	protein_off	0	0	No	No	No	No	4	3
153	5x66	5x67	protein_off	0	0	No	No	No	No	4	5
154	6x65	E3	protein_off	0	0	No	No	Yes	Yes	4	4
155	NT	NT	Shared	100	100	Yes	Yes	Yes	Yes	4	4
156	Lig	NT	Shared	100	100	Yes	Yes	Yes	Yes	0	4
157	1x24	Lig	Shared	100	30	No	No	Yes	Yes	3	0
158	1x35	1x39	Shared	100	100	Yes	No	Yes	Yes	6	8
159	1x35	7x35	Shared	100	43.75	Yes	No	No	No	6	3
160	1x39	7x39	Shared	100	100	Yes	Yes	No	No	8	6
161	1x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	8	8
162	1x43	2x57	Shared	100	50	No	No	No	No	7	7
163	1x43	2x58	Shared	100	100	No	No	No	No	7	9
164	1x46	2x54	Shared	100	30	No	No	No	No	8	6
165	1x50	2x50	Shared	100	100	No	No	No	Yes	9	9
166	1x50	7x50	Shared	100	100	No	No	No	No	9	9
167	1x53	2x47	Shared	100	50	Yes	No	No	No	8	9
168	2x37	2x40	Shared	100	100	No	No	No	Yes	7	8
169	2x38	2x42	Shared	100	100	Yes	No	Yes	Yes	6	7
170	2x42	3x45	Shared	100	100	Yes	Yes	Yes	No	7	6
171	2x42	3x46	Shared	100	100	Yes	Yes	No	No	7	9
172	2x42	3x49	Shared	100	100	Yes	Yes	Yes	No	7	8
173	2x43	7x53	Shared	100	100	No	No	Yes	Yes	8	9
174	2x45	3x42	Shared	100	100	No	Yes	Yes	Yes	9	7
175	2x45	4x46	Shared	100	100	No	Yes	No	No	9	7
176	2x45	4x50	Shared	100	100	No	Yes	Yes	Yes	9	9
177	2x46	7x49	Shared	100	100	No	No	No	Yes	9	9
178	2x49	3x38	Shared	100	100	No	No	No	No	8	7
179	2x50	7x46	Shared	100	100	No	Yes	No	No	9	8
180	2x50	7x49	Shared	100	100	No	Yes	No	Yes	9	9
181	2x53	3x32	Shared	100	100	No	Yes	Yes	Yes	7	7
182	2x53	3x35	Shared	100	100	No	Yes	No	No	7	8
183	2x53	7x42	Shared	100	100	No	Yes	Yes	Yes	7	8
184	2x56	2x60	Shared	100	100	No	Yes	No	No	7	7
185	2x57	7x42	Shared	100	100	No	No	Yes	Yes	7	8
186	2x59	E1x52	Shared	100	56.25	No	No	Yes	Yes	6	7
187	2x59	3x28	Shared	100	100	No	No	No	No	6	5
188	2x60	Lig	Shared	100	100	No	No	Yes	Yes	7	0
189	2x62	E1x52	Shared	100	32.5	No	No	Yes	Yes	5	7
190	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	4	9
191	E1x49	E2	Shared	100	100	No	No	Yes	Yes	3	3
192	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	Yes	9	7
193	3x25	E1x50	Shared	100	100	No	Yes	Yes	Yes	9	9
194	E1x50	E2x50	Shared	100	100	Yes	Yes	No	Yes	9	9
195	3x22	3x26	Shared	100	37.5	No	No	No	No	3	7
196	3x22	E2	Shared	100	100	No	No	Yes	Yes	3	3
197	3x25	E2x50	Shared	100	100	No	Yes	No	Yes	9	9
198	3x29	4x65	Shared	100	100	No	No	No	No	5	5
199	3x30	4x62	Shared	100	100	No	No	No	No	5	4
200	3x32	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
201	3x33	4x61	Shared	100	100	No	No	No	No	5	4
202	3x36	6x48	Shared	100	100	No	No	Yes	Yes	7	9
203	3x37	4x56	Shared	100	100	Yes	Yes	No	No	7	5
204	3x37	5x43	Shared	100	100	Yes	Yes	No	No	7	5
205	3x38	4x50	Shared	100	100	No	No	Yes	Yes	7	9
206	3x40	5x50	Shared	100	30	No	No	Yes	No	7	9
207	3x42	4x49	Shared	100	100	Yes	Yes	No	No	7	6
208	3x42	4x50	Shared	100	100	Yes	Yes	Yes	Yes	7	9
209	3x49	I2x57	Shared	100	100	Yes	No	No	Yes	8	6
210	3x51	3x55	Shared	100	100	Yes	No	No	No	8	7
211	3x51	5x57	Shared	100	100	Yes	No	No	Yes	8	8
212	3x51	5x60	Shared	100	100	Yes	No	No	No	8	4
213	3x53	I2x57	Shared	100	37.5	No	No	No	Yes	8	6
214	3x55	3x56	Shared	100	100	No	No	No	Yes	7	6
215	4x60	5x39	Shared	100	100	No	No	No	No	8	5
216	4x63	4x64	Shared	100	50	No	No	No	No	3	5
217	4x64	E2	Shared	100	100	No	No	Yes	Yes	5	3
218	4x64	5x35	Shared	100	100	No	No	Yes	No	5	3
219	4x65	E2x52	Shared	100	100	No	No	No	No	5	4
220	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
221	E2	Lig	Shared	100	100	Yes	Yes	Yes	Yes	3	0
222	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	3
223	E2x51	Lig	Shared	100	100	No	No	Yes	Yes	3	0
224	E2	E2x52	Shared	100	100	Yes	Yes	No	No	3	4
225	5x35	E2	Shared	100	100	Yes	No	Yes	Yes	3	3
226	5x36	E2	Shared	100	100	No	No	Yes	Yes	4	3
227	5x39	E2	Shared	100	100	No	No	Yes	Yes	5	3
228	5x40	6x59	Shared	100	100	No	No	No	No	5	5
229	5x44	6x56	Shared	100	50	No	No	No	No	5	5
230	5x47	6x52	Shared	100	100	No	No	No	No	8	8
231	6x44	6x48	Shared	100	100	Yes	No	Yes	Yes	9	9
232	6x48	7x41	Shared	100	50	Yes	Yes	No	No	9	8
233	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	9	9
234	6x51	6x55	Shared	100	100	Yes	No	No	No	7	6
235	6x51	7x38	Shared	100	100	Yes	No	No	No	7	6
236	6x57	E3	Shared	100	100	No	No	Yes	Yes	4	4
237	6x58	Lig	Shared	100	55	No	No	Yes	Yes	4	0
238	6x61	E3	Shared	100	100	No	No	Yes	Yes	4	4
239	7x26	E3	Shared	100	100	No	No	Yes	Yes	1	4
240	7x27	Lig	Shared	100	100	No	No	Yes	Yes	3	0
241	7x31	Lig	Shared	100	100	No	No	Yes	Yes	4	0
242	7x34	Lig	Shared	100	100	No	No	Yes	Yes	5	0
243	7x38	Lig	Shared	100	100	No	No	Yes	Yes	6	0
244	Lig	Lig	Shared	100	100	Yes	Yes	Yes	Yes	0	0
245	3x30	4x57	Shared	100	100	No	No	No	No	5	7
246	3x47	5x54	Shared	100	100	No	No	No	No	9	8
247	6x40	7x52	Shared	100	100	No	No	No	No	8	8
248	1x26	7x28	Shared	100	10	No	No	No	No	1	1
249	1x27	7x28	Shared	100	50	No	No	No	No	1	1
250	3x37	5x461	Shared	100	25	Yes	Yes	No	No	7	6
251	6x60	E3	Shared	100	100	No	No	Yes	Yes	5	4
252	E3	E3	Shared	100	100	Yes	Yes	Yes	Yes	4	4
253	E2	NT	Shared	100	100	Yes	Yes	Yes	Yes	3	4
254	1x45	7x47	Shared	33.3333	50	Yes	No	No	No	5	8
255	5x58	6x41	Shared	66.6667	100	No	Yes	No	No	9	8
256	5x54	6x44	Shared	33.3333	100	No	No	Yes	No	8	9
257	7x24	NT	Shared	50	50	No	No	Yes	Yes	6	4
258	6x48	6x52	Shared	33.3333	100	Yes	Yes	No	No	9	8
259	2x56	3x31	Shared	33.3333	100	No	Yes	Yes	No	7	5
260	5x51	6x45	Shared	66.6667	100	No	No	No	No	6	5
261	6x47	7x45	Shared	33.3333	100	No	No	Yes	No	8	9
262	1x57	2x40	Shared	33.3333	32.5	No	No	No	Yes	7	8
263	2x46	3x42	Shared	33.3333	100	No	No	Yes	Yes	9	7
264	1x60	8x53	Shared	33.3333	100	Yes	No	No	No	5	5
265	3x44	5x53	Shared	33.3333	100	No	No	No	No	7	6
266	6x39	7x52	Shared	50	25	No	No	No	No	5	8
267	6x51	7x37	Shared	66.6667	50	Yes	No	Yes	No	7	7
268	4x59	4x60	Shared	0	42.5	No	No	No	No	4	8
269	3x34	4x50	Shared	33.3333	100	No	No	Yes	Yes	5	9
270	6x36	7x56	Shared	66.6667	100	No	No	Yes	No	8	7
271	5x49	5x50	Shared	33.3333	75	No	No	Yes	No	6	9
272	5x41	5x45	Shared	16.6667	30	No	No	No	No	4	5
273	6x49	6x50	Shared	16.6667	60	No	No	No	No	6	9
274	1x39	2x61	Shared	33.3333	62.5	Yes	Yes	No	No	8	6
275	3x54	5x61	Shared	33.3333	100	No	No	No	No	8	8
276	6x30	I3	Shared	33.3333	100	No	No	No	Yes	7	3
277	1x49	7x50	Shared	66.6667	12.5	No	No	No	No	8	9
278	5x45	5x48	Shared	50	2.5	No	No	No	No	5	4
279	3x44	5x50	Shared	33.3333	75	No	No	Yes	No	7	9
280	3x48	5x57	Shared	0	30	No	No	No	Yes	7	8
281	5x65	6x34	Shared	50	30	No	No	No	No	8	6
282	1x57	2x44	Shared	33.3333	100	No	No	No	No	7	6
283	1x48	1x49	Shared	33.3333	27.5	No	No	No	No	3	8
284	1x47	2x54	Shared	50	30	No	Yes	No	No	6	6
285	I2x53	I2x57	Shared	33.3333	30	No	No	No	Yes	5	6
286	4x39	4x43	Shared	33.3333	30	No	No	No	No	2	4
287	5x62	5x66	Shared	33.3333	50	No	Yes	No	No	4	4
288	3x34	4x54	Shared	0	65	No	No	No	No	5	4
289	3x21	E1x50	Shared	0	0	No	No	Yes	Yes	8	9
290	1x36	2x65	Shared	0	35	No	No	No	No	6	4
291	8x52	8x53	Shared	33.3333	50	No	No	No	No	5	5
292	E1	NT	Shared	33.3333	100	No	Yes	Yes	Yes	0	4
293	3x27	3x31	Shared	16.6667	100	No	No	Yes	No	5	5
294	2x48	4x50	Shared	0	30	No	No	Yes	Yes	6	9
295	1x58	2x44	Shared	0	0	No	No	No	No	3	6
296	I2x52	I2x56	Shared	33.3333	100	No	Yes	No	No	5	4
297	7x23	7x26	Shared	33.3333	27.5	No	No	No	No	4	1
298	2x41	I1x50	Shared	33.3333	15	No	No	No	No	7	6
299	8x56	8x57	Shared	33.3333	25	No	No	No	No	4	4
300	1x55	1x59	Shared	0	67.5	No	No	No	No	4	4
301	1x36	2x64	Shared	0	32.5	No	No	No	No	6	5
302	8x50	8x54	Shared	16.6667	100	No	Yes	No	No	8	6
303	7x56	8x47	Shared	0	0	Yes	No	No	No	7	8
304	2x40	I1x51	Shared	0	35	No	Yes	No	No	8	7
305	8x48	8x51	Shared	0	50	No	No	No	No	5	8
306	5x55	5x59	Shared	0	25	No	No	No	No	4	3
307	1x42	7x42	protein_on	0	100	No	No	Yes	Yes	7	8
308	1x53	7x54	protein_on	0	100	Yes	No	No	No	8	7
309	1x56	8x50	protein_on	0	100	No	No	No	Yes	7	8
310	2x38	I2x57	protein_on	0	100	Yes	No	No	Yes	6	6
311	2x39	3x49	protein_on	0	100	No	No	Yes	No	8	8
312	2x42	4x42	protein_on	0	100	Yes	Yes	No	No	7	7
313	2x50	3x39	protein_on	0	100	No	Yes	No	No	9	9
314	2x53	7x46	protein_on	0	100	No	Yes	No	No	7	8
315	2x56	3x32	protein_on	0	100	No	Yes	Yes	Yes	7	7
316	3x25	E2	protein_on	0	100	No	Yes	Yes	Yes	9	3
317	3x34	4x57	protein_on	0	100	No	No	No	No	5	7
318	3x36	3x37	protein_on	0	100	No	No	Yes	Yes	7	7
319	3x41	4x49	protein_on	0	100	Yes	No	No	No	5	6
320	3x43	7x53	protein_on	0	100	No	No	Yes	Yes	8	9
321	3x47	5x57	protein_on	0	100	No	No	No	Yes	9	8
322	3x47	5x58	protein_on	0	100	No	No	No	Yes	9	9
323	3x50	5x58	protein_on	0	100	Yes	No	No	Yes	9	9
324	3x50	7x53	protein_on	0	100	Yes	No	Yes	Yes	9	9
325	3x52	3x56	protein_on	0	100	No	No	No	Yes	5	6
326	3x55	5x64	protein_on	0	100	No	No	No	No	7	5
327	I2x52	I2x55	protein_on	0	100	No	Yes	No	No	5	3
328	4x38	4x40	protein_on	0	100	No	No	No	No	6	4
329	4x38	4x41	protein_on	0	100	No	No	No	Yes	6	3
330	5x32	E2	protein_on	0	100	No	No	Yes	Yes	3	3
331	5x31	5x35	protein_on	0	100	No	No	Yes	No	3	3
332	5x38	5x42	protein_on	0	100	No	No	No	No	3	3
333	5x44	6x52	protein_on	0	100	No	No	No	No	5	8
334	5x51	6x44	protein_on	0	100	No	No	Yes	No	6	9
335	5x57	5x58	protein_on	0	100	No	Yes	No	Yes	8	9
336	5x58	5x61	protein_on	0	100	No	Yes	No	No	9	8
337	5x58	6x37	protein_on	0	100	No	Yes	No	No	9	8
338	5x58	6x40	protein_on	0	100	No	Yes	No	No	9	8
339	5x62	6x37	protein_on	0	100	No	Yes	No	No	4	8
340	6x40	7x53	protein_on	0	100	No	No	Yes	Yes	8	9
341	6x45	6x49	protein_on	0	100	No	No	No	No	5	6
342	6x61	Lig	protein_on	0	100	No	No	Yes	Yes	4	0
343	7x45	7x49	protein_on	0	100	Yes	No	No	Yes	9	9
344	7x49	7x53	protein_on	0	100	No	Yes	Yes	Yes	9	9
345	7x54	8x50	protein_on	0	100	No	No	No	Yes	7	8
346	7x55	8x50	protein_on	0	100	No	No	No	Yes	7	8
347	E2x52	Lig	protein_on	0	100	No	No	Yes	Yes	4	0
348	2x52	3x35	protein_on	0	100	No	No	No	No	7	8
349	E1x51	E1x52	protein_on	0	100	No	No	Yes	Yes	3	7
350	4x65	E2x50	protein_on	0	100	No	No	No	Yes	5	9
351	E2	E2x50	protein_on	0	100	Yes	Yes	No	Yes	3	9
352	5x33	6x59	protein_on	0	100	No	No	No	No	2	5
353	7x31	NT	protein_on	0	100	No	No	Yes	Yes	4	4
354	1x29	1x32	protein_on	0	100	No	No	No	No	2	4
355	1x32	NT	protein_on	0	100	No	No	Yes	Yes	4	4
356	2x63	E1	protein_on	0	100	No	No	No	Yes	4	0
357	E1	E2	protein_on	0	100	No	Yes	Yes	Yes	0	3
358	E1	E1	protein_on	0	100	No	Yes	No	Yes	0	0
359	2x64	NT	protein_on	0	100	No	No	Yes	Yes	5	4
360	I1	I1	protein_on	0	100	No	Yes	No	Yes	0	0
361	8x52	I1	protein_on	0	100	No	No	No	Yes	5	0
362	2x67	E1	protein_on	0	100	No	No	No	Yes	0	0
363	3x25	E1	protein_on	0	100	No	Yes	No	Yes	9	0
364	3x29	E2	protein_on	0	100	No	No	Yes	Yes	5	3
365	4x60	E2	protein_on	0	100	No	No	Yes	Yes	8	3
366	CT	CT	protein_on	0	100	No	No	No	No	4	4
367	3x46	3x50	protein_on	0	67.5	No	No	Yes	No	9	9
368	5x68	I3	protein_on	0	50	No	No	No	Yes	0	3
369	1x38	7x39	protein_on	0	50	No	No	No	No	6	6
370	2x41	4x43	protein_on	0	37.5	No	No	No	No	7	4
371	6x54	7x34	protein_on	0	75	No	Yes	No	No	5	5
372	2x59	3x24	protein_on	0	50	No	No	No	No	6	6
373	7x51	7x55	protein_on	0	62.5	No	No	No	No	6	7
374	3x38	4x53	protein_on	0	67.5	No	No	No	No	7	7
375	3x32	3x33	protein_on	0	50	Yes	Yes	No	No	7	5
376	2x42	4x45	protein_on	0	50	Yes	Yes	No	No	7	6
377	1x59	8x57	protein_on	0	62.5	No	No	No	No	4	4
378	2x43	7x54	protein_on	0	52.5	No	No	No	No	8	7
379	6x53	6x54	protein_on	0	37.5	No	No	No	Yes	6	5
380	3x40	6x48	protein_on	0	75	No	No	Yes	Yes	7	9
381	1x43	1x47	protein_on	0	50	No	No	No	Yes	7	6
382	5x40	6x58	protein_on	0	35	No	No	No	No	5	4
383	5x56	5x60	protein_on	0	35	No	No	No	No	4	4
384	2x41	2x45	protein_on	0	25	No	No	No	Yes	7	9
385	6x42	6x46	protein_on	0	30	No	No	No	No	5	5
386	5x62	6x34	protein_on	0	62.5	No	Yes	No	No	4	6
387	5x37	6x59	protein_on	0	60	No	No	No	No	3	5
388	2x62	2x66	protein_on	0	50	No	No	No	No	5	4
389	1x57	2x43	protein_on	0	62.5	No	No	No	No	7	8
390	1x29	1x33	protein_on	0	36.25	No	No	No	No	2	3
391	6x47	7x43	protein_on	0	47.5	No	No	No	No	8	5
392	5x64	5x67	protein_on	0	30	No	No	No	No	5	5
393	1x47	2x51	protein_on	0	47.5	No	Yes	No	No	6	7
394	1x54	2x44	protein_on	0	22.5	No	No	No	No	7	6
395	1x61	2x40	protein_on	0	25	No	No	No	Yes	0	8
396	6x43	7x48	protein_on	0	25	No	No	No	No	6	6
397	6x57	7x30	protein_on	0	62.5	No	No	No	No	4	5
398	6x50	7x40	protein_on	0	50	No	No	No	No	9	8
399	I1	I1x48	protein_on	0	25	No	Yes	No	No	0	5
400	1x40	2x61	protein_on	0	25	No	No	No	No	3	6
401	1x42	7x47	protein_on	0	52.5	No	No	No	No	7	8
402	2x55	2x56	protein_on	0	25	No	No	No	Yes	5	7
403	5x55	6x41	protein_on	0	37.5	No	No	No	No	4	8
404	5x65	I3	protein_on	0	37.5	No	No	No	Yes	8	3
405	1x34	1x35	protein_on	0	25	No	No	Yes	No	6	6
406	5x59	5x63	protein_on	0	25	No	No	No	No	3	3
407	1x59	1x60	protein_on	0	25	No	No	Yes	No	4	5
408	6x54	7x36	protein_on	0	25	No	Yes	No	No	5	5
409	1x52	8x54	protein_on	0	30	No	No	No	No	6	6
410	5x37	5x41	protein_on	0	42.5	No	No	No	No	3	4
411	7x48	7x51	protein_on	0	30	No	No	No	No	6	6
412	8x48	8x52	protein_on	0	32.5	No	No	No	No	5	5
413	1x44	1x48	protein_on	0	25	No	No	No	No	5	3
414	4x48	4x49	protein_on	0	25	No	No	No	No	3	6
415	4x41	4x45	protein_on	0	50	No	Yes	No	No	3	6
416	6x31	6x35	protein_on	0	17.5	No	No	No	No	5	5
417	5x39	5x42	protein_on	0	32.5	No	No	No	No	5	3
418	1x47	1x51	protein_on	0	35	No	Yes	No	No	6	3
419	1x28	Lig	protein_on	0	25	No	No	Yes	Yes	1	0
420	8x51	8x55	protein_on	0	25	No	No	No	No	8	4
421	6x32	7x56	protein_on	0	30	No	No	Yes	No	7	7
422	7x32	E3	protein_on	0	25	No	No	Yes	Yes	1	4
423	8x54	8x58	protein_on	0	25	No	No	No	No	6	5
424	4x56	5x46	protein_on	0	17.5	No	No	No	No	5	4
425	6x62	Lig	protein_on	0	50	No	No	Yes	Yes	3	0
426	7x28	NT	protein_on	0	30	No	No	Yes	Yes	1	4
427	1x56	8x53	protein_on	0	25	No	No	No	No	7	5
428	3x56	I2x52	protein_on	0	20	No	Yes	No	Yes	6	5
429	8x58	CT	protein_on	0	25	No	No	No	No	5	4
430	5x31	5x34	protein_on	0	30	No	No	No	No	3	1
431	4x41	4x44	protein_on	0	25	No	Yes	No	No	3	1
432	2x40	8x49	protein_on	0	30	No	Yes	No	No	8	6
433	5x65	6x33	protein_on	0	25	No	No	No	No	8	8
434	1x31	7x32	protein_on	0	25	No	No	No	No	5	1
435	I2x52	I2x54	protein_on	0	25	No	Yes	No	No	5	4
436	6x29	I3	protein_on	0	25	No	No	No	Yes	6	3
437	3x22	3x23	protein_on	0	25	No	No	No	No	3	3
438	6x54	7x33	protein_on	0	5	No	Yes	No	No	5	6
439	4x52	4x56	protein_on	0	25	No	No	No	No	4	5
440	6x32	6x35	protein_on	0	25	No	No	No	No	7	5
441	2x40	I1x49	protein_on	0	25	No	Yes	No	No	8	5
442	6x32	6x33	protein_on	0	25	No	No	No	No	7	8
443	5x62	6x38	protein_on	0	20	No	Yes	No	No	4	5
444	6x45	6x46	protein_on	0	5	No	No	No	No	5	5
445	6x28	6x29	protein_on	0	27.5	No	No	No	No	5	6
446	1x37	1x41	protein_on	0	25	No	No	No	No	5	5
447	5x51	5x52	protein_on	0	5	No	No	No	No	6	4
448	6x27	I3	protein_on	0	25	No	No	No	Yes	0	3
449	5x29	E2	protein_on	0	25	No	No	Yes	Yes	0	3
450	7x25	7x29	protein_on	0	25	No	No	No	No	1	2
451	1x36	1x37	protein_on	0	25	No	No	No	No	6	5
452	1x30	1x33	protein_on	0	25	No	No	No	No	2	3
453	8x60	8x61	protein_on	0	18.75	No	No	No	No	0	0
454	7x29	7x32	protein_on	0	12.5	No	No	No	No	2	1
455	3x56	I2	protein_on	0	12.5	No	Yes	No	No	6	0
456	6x64	E3	protein_on	0	17.5	No	No	Yes	Yes	1	4
457	4x48	4x51	protein_on	0	0	No	No	No	No	3	4
458	1x25	Lig	protein_on	0	5	No	No	Yes	Yes	3	0
459	6x62	6x63	protein_on	0	5	No	No	No	No	3	1
460	8x57	8x61	protein_on	0	12.5	No	No	No	No	4	0
461	I2x51	I2x52	protein_on	0	12.5	No	No	No	Yes	5	5
462	4x55	4x59	protein_on	0	0	No	No	No	No	4	4
463	4x47	4x51	protein_on	0	0	No	No	No	No	4	4
464	6x65	7x30	protein_on	0	5	No	No	No	No	4	5
465	3x56	I2x50	protein_on	0	0	No	Yes	No	No	6	7
466	5x29	5x30	protein_on	0	0	No	No	No	No	0	0
467	I2x52	I2x58	protein_on	0	6.25	No	Yes	No	No	5	0
468	4x54	4x58	protein_on	0	0	No	No	No	No	4	0
469	8x59	8x60	protein_on	0	0	No	No	No	No	3	0
470	6x26	6x30	protein_on	0	0	No	No	No	No	0	7
471	4x41	I2x59	protein_on	0	0	No	Yes	No	No	3	0

Orange: nodes, hubs and links specific of protein_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of protein_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	protein_off Avg Int. Strength	protein_on Avg Int. Strength	protein_off Num Of Links	protein_on Num Of Links	ConSurf
1	1x35	protein_off	0	0	4	3	6
2	1x45	protein_off	0	0	4	1	5
3	1x53	protein_off	33.3333	0	4	2	8
4	1x60	protein_off	0	0	4	2	5
5	2x38	protein_off	0	0	4	2	6
6	3x31	protein_off	0	0	4	2	5
7	3x41	protein_off	33.3333	12.5	4	1	5
8	3x45	protein_off	33.3333	0	4	1	6
9	3x49	protein_off	33.3333	10	4	3	8
10	3x50	protein_off	66.6667	0	5	3	9
11	3x51	protein_off	66.6667	37.5	6	3	8
12	5x35	protein_off	16.6667	10	4	3	3
13	5x50	protein_off	0	0	4	3	9
14	6x44	protein_off	33.3333	27.5	6	3	9
15	6x51	protein_off	33.3333	12.5	5	3	7
16	7x37	protein_off	0	0	4	1	7
17	7x45	protein_off	66.6667	20	6	3	9
18	7x56	protein_off	0	0	4	3	7
19	NT	Shared	66.6667	62.5	8	10	4
20	1x39	Shared	50	17.5	4	4	8
21	2x42	Shared	33.3333	62.5	4	6	7
22	E1x50	Shared	100	50	7	5	9
23	E1x52	Shared	0	25	4	4	7
24	3x32	Shared	83.3333	20	4	4	7
25	3x37	Shared	33.3333	58.75	5	4	7
26	3x42	Shared	33.3333	32.5	4	4	7
27	4x50	Shared	33.3333	12.5	5	5	9
28	E2	Shared	100	100	15	19	3
29	6x48	Shared	100	70	6	6	9
30	E3	Shared	66.6667	25	10	8	4
31	7x42	Shared	50	41.25	4	4	8
32	7x53	Shared	66.6667	72.5	7	5	9
33	Lig	Shared	100	75	19	18	0
34	1x47	protein_on	0	0	1	4	6
35	2x40	protein_on	0	12.5	3	6	8
36	2x45	protein_on	0	0	3	4	9
37	2x50	protein_on	33.3333	50	3	4	9
38	2x53	protein_on	66.6667	37.5	3	4	7
39	2x56	protein_on	0	12.5	2	4	7
40	3x25	protein_on	0	12.5	2	4	9
41	3x56	protein_on	0	0	2	5	6
42	I2x52	protein_on	0	0	1	6	5
43	I2x57	protein_on	33.3333	0	3	4	6
44	4x41	protein_on	0	0	1	4	3
45	E2x50	protein_on	0	0	2	4	9
46	5x57	protein_on	0	0	2	4	8
47	5x58	protein_on	33.3333	87.5	3	7	9
48	5x62	protein_on	0	0	2	4	4
49	I3	protein_on	0	0	1	5	3
50	6x54	protein_on	0	0	1	4	5
51	7x49	protein_on	0	40	2	4	9
52	8x50	protein_on	0	38.75	3	4	8
53	E1	protein_on	0	62.5	1	7	0
54	I1	protein_on	0	12.5	1	4	0

Orange: nodes, hubs and links specific of protein_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of protein_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	protein_off Recurrence	protein_on Recurrence	protein_off Hub1?	protein_on Hub1?	protein_off Hub2?	protein_on Hub2?	ConSurf1	ConSurf2
1	7x35	Lig	protein_off	10.0243	0	No	No	Yes	Yes	3	0
2	7x38	7x42	protein_off	13.4129	0	No	No	Yes	Yes	6	8
3	1x49	7x50	protein_off	12.6397	3.79701	No	No	No	No	8	9
4	1x50	7x50	protein_off	51.7252	5.04945	No	No	No	No	9	9
5	1x50	2x50	protein_off	55.7367	6.29467	No	No	No	Yes	9	9
6	7x45	7x46	protein_off	88.5001	0	Yes	No	No	No	9	8
7	6x48	6x51	protein_off	100	0	Yes	Yes	Yes	No	9	7
8	6x51	Lig	protein_off	90.254	0	Yes	No	Yes	Yes	7	0
9	1x53	7x50	protein_off	41.078	0	Yes	No	No	No	8	9
10	1x53	7x53	protein_off	24.8465	0	Yes	No	Yes	Yes	8	9
11	1x60	7x53	protein_off	11.7296	0	Yes	No	Yes	Yes	5	9
12	2x42	3x45	protein_off	24.7714	1.11528	Yes	Yes	Yes	No	7	6
13	3x45	4x49	protein_off	33.6161	0	Yes	No	No	No	6	6
14	3x42	4x49	protein_off	34.8001	6.29467	Yes	Yes	No	No	7	6
15	2x42	3x49	protein_off	16.7484	4.82567	Yes	Yes	Yes	No	7	8
16	3x49	3x50	protein_off	12.3305	0	Yes	No	Yes	No	8	9
17	2x56	2x60	protein_off	12.3923	2.37133	No	Yes	No	No	7	7
18	E1x50	E2	protein_off	17.0135	0	Yes	Yes	Yes	Yes	9	3
19	3x41	5x50	protein_off	16.6954	0	Yes	No	Yes	No	5	9
20	3x40	5x50	protein_off	45.2485	4.38533	No	No	Yes	No	7	9
21	3x40	6x44	protein_off	46.353	0	No	No	Yes	No	7	9
22	3x43	6x41	protein_off	10.899	0	No	No	No	No	8	8
23	3x43	6x44	protein_off	16.0018	0	No	No	Yes	No	8	9
24	3x48	5x57	protein_off	25.1204	1.87685	No	No	No	Yes	7	8
25	3x48	5x53	protein_off	26.3751	0	No	No	No	No	7	6
26	3x44	5x53	protein_off	27.6209	1.10445	No	No	No	No	7	6
27	3x44	5x50	protein_off	28.858	2.2053	No	No	Yes	No	7	9
28	3x51	5x60	protein_off	14.4776	3.75009	Yes	No	No	No	8	4
29	6x59	6x60	protein_off	11.4601	0	No	No	No	No	5	5
30	6x60	E3	protein_off	13.3157	1.28131	No	No	Yes	Yes	5	4
31	E3	NT	protein_off	14.9945	0	Yes	Yes	Yes	Yes	4	4
32	6x51	7x37	protein_off	12.4409	1.28131	Yes	No	Yes	No	7	7
33	3x54	5x60	protein_off	13.1345	0	No	No	No	No	8	4
34	2x56	3x31	protein_off	10.2408	3.26644	No	Yes	Yes	No	7	5
35	1x53	1x57	protein_off	14.3009	0	Yes	No	No	No	8	7
36	2x64	E1x50	protein_off	10.6826	0	No	No	Yes	Yes	5	9
37	3x54	5x61	protein_off	10.4219	1.86602	No	No	No	No	8	8
38	2x63	E1x50	protein_off	14.8133	0.516134	No	No	Yes	Yes	4	9
39	2x63	Lig	protein_off	15.4849	0	No	No	Yes	Yes	4	0
40	6x58	E3	protein_off	13.0152	0	No	No	Yes	Yes	4	4
41	6x58	Lig	protein_off	13.8944	9.73796	No	No	Yes	Yes	4	0
42	6x44	7x45	protein_off	24.4577	0	Yes	No	Yes	No	9	9
43	Lig	NT	Shared	14.9856	15.6609	Yes	Yes	Yes	Yes	0	4
44	2x50	7x46	Shared	87.8993	98.0546	No	Yes	No	No	9	8
45	6x48	7x45	Shared	67.4575	22.4067	Yes	Yes	Yes	No	9	9
46	2x46	3x42	Shared	46.1542	26.7956	No	No	Yes	Yes	9	7
47	2x46	7x49	Shared	47.241	27.9037	No	No	No	Yes	9	9
48	2x50	7x49	Shared	48.319	100	No	Yes	No	Yes	9	9
49	E1x50	E1x52	Shared	12.8253	16.8231	Yes	Yes	Yes	Yes	9	7
50	6x44	6x48	Shared	40.19	11.0806	Yes	No	Yes	Yes	9	9
51	3x51	5x57	Shared	23.8569	28.0842	Yes	No	No	Yes	8	8
52	E2	Lig	Shared	41.8025	41.3268	Yes	Yes	Yes	Yes	3	0
53	2x53	7x42	protein_on	0.631765	24.1067	No	Yes	Yes	Yes	7	8
54	2x53	3x32	protein_on	3.06163	88.6992	No	Yes	Yes	Yes	7	7
55	3x32	Lig	protein_on	2.0455	84.0793	Yes	Yes	Yes	Yes	7	0
56	2x53	7x46	protein_on	0	97.7478	No	Yes	No	No	7	8
57	2x43	7x54	protein_on	0	29.6614	No	No	No	No	8	7
58	2x43	7x53	protein_on	1.35189	39.8073	No	No	Yes	Yes	8	9
59	7x49	7x53	protein_on	0	92.8896	No	Yes	Yes	Yes	9	9
60	1x56	8x50	protein_on	0	17.0613	No	No	No	Yes	7	8
61	7x54	8x50	protein_on	0	26.4094	No	No	No	Yes	7	8
62	1x57	2x43	protein_on	0	11.142	No	No	No	No	7	8
63	1x56	8x53	protein_on	0	15.8919	No	No	No	No	7	5
64	2x42	3x46	protein_on	1.43583	17.5125	Yes	Yes	No	No	7	9
65	3x46	3x50	protein_on	0	18.5014	No	No	Yes	No	9	9
66	3x50	7x53	protein_on	0	47.8055	Yes	No	Yes	Yes	9	9
67	3x42	4x50	protein_on	8.42501	13.0369	Yes	Yes	Yes	Yes	7	9
68	3x25	E1x50	protein_on	2.27966	10.3299	No	Yes	Yes	Yes	9	9
69	3x25	E2	protein_on	0	10.745	No	Yes	Yes	Yes	9	3
70	E2	E2x50	protein_on	0	10.5031	Yes	Yes	No	Yes	3	9
71	7x45	7x49	protein_on	0	25.3736	Yes	No	No	Yes	9	9
72	3x50	5x58	protein_on	0	36.5841	Yes	No	No	Yes	9	9
73	5x58	6x40	protein_on	0	33.5848	No	Yes	No	No	9	8
74	6x40	7x53	protein_on	0	35.2703	No	No	Yes	Yes	8	9
75	5x57	5x58	protein_on	0	29.5423	No	Yes	No	Yes	8	9
76	3x51	3x55	protein_on	1.43141	22.746	Yes	No	No	No	8	7
77	3x55	3x56	protein_on	0	17.3428	No	No	No	Yes	7	6
78	3x56	I2x52	protein_on	0	10.6006	No	Yes	No	Yes	6	5
79	5x58	6x37	protein_on	0	32.6572	No	Yes	No	No	9	8
80	5x62	6x37	protein_on	0	30.9211	No	Yes	No	No	4	8
81	5x65	6x34	protein_on	7.64303	23.9226	No	No	No	No	8	6
82	5x62	6x34	protein_on	0	25.684	No	Yes	No	No	4	6
83	6x32	6x33	protein_on	0	11.0373	No	No	No	No	7	8
84	5x65	6x33	protein_on	0	12.8636	No	No	No	No	8	8
85	6x61	E3	protein_on	1.89529	12.9719	No	No	Yes	Yes	4	4
86	6x61	Lig	protein_on	0	13.8309	No	No	Yes	Yes	4	0

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
NT	NT	Shared	8.21333	624.592	1	1	1	1
Lig	NT	Shared	35.62	96.2575	1	1	0	1
1x24	Lig	Shared	7.55167	1.471	0	0	1	0
1x35	7x35	Shared	6.13833	2.545	0	0	2	1
2x53	3x32	Shared	4.12833	6.12925	0	0	2	1
2x53	7x42	Shared	4.76	4.79088	0	0	2	2
2x56	2x60	Shared	3.88667	3.80288	0	0	2	1
2x60	3x32	protein_off	9.475	0	1	1	1	1
2x60	Lig	Shared	11.915	8.8215	1	1	1	0
2x63	E1x50	Shared	6.08833	7.38662	1	1	1	2
2x63	Lig	protein_off	6.79167	0	1	1	1	0
E1x49	E2	Shared	13.8333	5.405	1	0	2	1
3x25	E1x50	Shared	4.57	5.2255	1	1	2	2
E1x50	E2	protein_off	4.55833	0	1	1	2	1
E1x50	E2x50	Shared	12.19	5.84237	1	1	2	2
3x22	E2	Shared	8.71833	4.76925	1	1	2	1
3x25	E2x50	Shared	7.28	8.85775	1	1	2	2
3x29	4x65	Shared	12.0167	9.90075	0	1	2	2
3x32	Lig	Shared	4.00167	4.961	1	1	1	0
3x33	4x61	Shared	13.7667	4.01663	0	0	2	2
3x36	6x48	Shared	6.15667	5.02063	0	0	2	2
4x60	5x39	Shared	5.77667	4.0705	0	1	2	2
4x61	5x39	protein_off	6.525	0	0	0	2	2
4x64	E2	Shared	12.4517	9.4645	1	1	2	1
4x64	5x35	Shared	4.84333	4.251	1	1	2	2
4x65	E2x52	Shared	4.59167	4.44425	0	0	2	1
E2	E2	Shared	41.05	40.5382	1	1	1	1
E2	Lig	Shared	42.3267	25.1613	1	1	1	0
E2	E2x51	Shared	12.3783	8.361	1	1	1	1
E2x51	Lig	Shared	5.435	10.8891	1	1	1	0
E2	E2x52	Shared	7.485	5.17262	1	1	1	1
5x35	E2	Shared	11.55	8.0045	1	1	2	1
5x36	E2	Shared	7.86833	7.62325	1	0	2	1
5x39	E2	Shared	5.61	3.9825	1	1	2	1
5x32	Lig	protein_off	3.96167	0	1	0	1	0
5x34	5x35	protein_off	11.96	0	1	0	2	2
5x44	6x56	Shared	4.35833	2.65963	1	0	1	2
6x48	6x51	protein_off	5.47167	0	1	0	2	1
6x51	6x55	Shared	4.17	6.6675	1	0	1	2
6x51	7x38	Shared	6.64167	3.68063	1	0	1	1
6x51	Lig	protein_off	10.805	0	1	0	1	0
6x58	Lig	Shared	7.64667	2.97375	1	1	1	0
6x61	E3	Shared	4.61167	3.71463	0	1	1	2
7x27	Lig	Shared	8.13	5.62413	0	0	1	0
7x31	Lig	Shared	6.22667	4.33563	1	1	1	0
7x34	Lig	Shared	5.27	4.10525	0	1	1	0
7x35	7x39	protein_off	5.67333	0	1	0	1	2
7x35	Lig	protein_off	4.115	0	1	0	1	0
7x38	Lig	Shared	4.58167	5.8295	1	1	1	0
5x32	5x35	protein_off	3.91167	0	1	0	1	2
7x38	7x42	protein_off	6.13	0	1	1	1	2
1x27	7x28	Shared	4.08667	2.577	0	0	2	2
3x32	3x36	protein_off	4.08667	0	1	1	1	2
4x61	E2x52	protein_off	4.36667	0	0	0	2	1
E3	E3	Shared	7.97	4.82163	1	1	2	2
E3	NT	protein_off	4.54667	0	1	1	2	1
E2	NT	Shared	4.77	5.23687	1	1	1	1
5x32	5x34	protein_off	5.11	0	1	0	1	2
6x58	E3	protein_off	5.47667	0	1	1	1	2
5x44	Lig	protein_off	3.74	0	1	0	1	0
7x24	NT	Shared	3.64	2.275	0	0	2	1
7x36	7x37	protein_off	3.62833	0	0	0	2	2
6x48	6x52	Shared	3.59333	3.817	1	0	2	2
1x27	7x31	protein_off	3.4	0	0	0	2	1
6x51	7x37	Shared	3.34333	2.8765	1	0	1	2
7x33	7x37	protein_off	3.23333	0	0	0	2	2
1x25	NT	protein_off	3.11	0	0	0	1	1
6x54	Lig	protein_off	3.07	0	0	0	1	0
2x64	E1x50	protein_off	3.01333	0	0	1	2	2
5x31	E2	protein_off	2.78333	0	0	0	2	1
6x62	E3	protein_off	2.19167	0	0	1	1	2
E1	NT	Shared	1.91667	12.6912	0	1	2	1
1x32	1x35	protein_off	1	0	0	1	2	2
1x28	E2	protein_off	0.873333	0	0	0	1	1
2x56	3x32	protein_on	0	4.26612	0	0	2	1
3x25	E2	protein_on	0	3.33025	1	1	2	1
5x32	E2	protein_on	0	3.63762	1	0	1	1
5x31	5x35	protein_on	0	4.69388	0	0	2	2
5x44	6x52	protein_on	0	3.759	1	0	1	2
6x61	Lig	protein_on	0	3.76575	0	1	1	0
E2x52	Lig	protein_on	0	4.007	1	1	1	0
4x65	E2x50	protein_on	0	3.39975	0	0	2	2
E2	E2x50	protein_on	0	4.15087	1	1	1	2
7x31	NT	protein_on	0	3.297	1	1	1	1
1x32	NT	protein_on	0	4.57688	0	1	2	1
2x63	E1	protein_on	0	5.64625	1	1	1	2
E1	E2	protein_on	0	4.9625	0	1	2	1
E1	E1	protein_on	0	21.7513	0	1	2	2
2x64	NT	protein_on	0	5.3475	0	1	2	1
3x25	E1	protein_on	0	4.015	1	1	2	2
3x29	E2	protein_on	0	3.875	0	1	2	1
4x60	E2	protein_on	0	4.53125	0	1	2	1
6x54	7x34	protein_on	0	3.22137	0	0	1	1
3x32	3x33	protein_on	0	3.128	1	1	1	2
6x53	6x54	protein_on	0	3	0	0	2	1
5x40	6x58	protein_on	0	2.97825	0	0	2	1
6x54	7x36	protein_on	0	2.115	0	0	1	2
1x28	Lig	protein_on	0	1.88025	0	0	1	0
6x62	Lig	protein_on	0	1.7195	0	1	1	0
7x28	NT	protein_on	0	1.718	0	1	2	1
5x31	5x34	protein_on	0	1.58713	0	0	2	2
6x54	7x33	protein_on	0	1.33987	0	0	1	2
5x29	E2	protein_on	0	1.105	0	1	2	1
1x25	Lig	protein_on	0	0.804	0	0	1	0
6x62	6x63	protein_on	0	0.776	0	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	protein_off	ccr_off chemokine_off gnrh_off
	protein_on	ccr_on chemokine_on gphr_on chemerin_on

Network Difference
Value	protein_off	protein_on
I_min	3.85333	3.2875
Number of Linked Nodes	284	292
Number of Specific Nodes	3 (1.06%)	11 (3.77%)
Number of Shared Nodes	281 (98.94%)	281 (96.23%)
Number of Links	306	317
Number of Specific Links	154 (50.33%)	165 (52.05%)
Number of Shared Links	152 (49.67%)	152 (47.95%)
Number of Hubs	33	36
Number of Specific Hubs	18 (54.55%)	21 (58.33%)
Number of Shared Hubs	15 (45.45%)	15 (41.67%)
Average % Shared Neighbours (Jaccard)	34.39
Average % Shared Neighbours (Otsuka)	42.91
Average % Shared Neighbours (Overlap Coefficient)	51.28
Average % Shared Cliques (k3-6)	81.94
Graphlets Similarity	0.469606

Paths Difference
Value	protein_off	protein_on
Number Of Nodes in MetaPath	52	44
Specific Nodes in MetaPath	31 (59.62%)	23 (52.27%)
Shared Nodes in MetaPath	281 (98.94%)	281 (98.94%)
Number Of Links MetaPath	52	44
Specific Links in MetaPath	42 (80.77%)	34 (77.27%)
Shared Links in MetaPath	152 (49.67%)	152 (49.67%)
Number of Shortest Paths	45343	52664
Length Of Smallest Path	3	3
Average Path Length	12.2016	12.1502
Length of Longest Path	31	25
Minimum Path Strength	1.2625	0.530313
Average Path Strength	6.42834	5.76165
Maximum Path Strength	27.3892	36.294
Minimum Path Correlation	0.7	0.70125
Average Path Correlation	0.909241	0.913655
Maximum Path Correlation	0.986667	0.99175
Minimum % Of Corr. Nodes	3.57143	4.54545
Average % Of Corr. Nodes	40.7563	42.7874
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	43.0943	48.7219
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download protein_off_on.zip<

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.