Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.S1.02 5.7825495
2G.S1.05 5.803519
3G.S1.06 5.25125478
4G.H1.01 4.85786779
5G.H1.04 3.842577
6G.S2.01 4.0375419
7G.S2.03 5.25375419
8G.S2.08 10.485495
9G.S3.01 5.575494
10G.S3.03 6.87167697
11G.S3.04 9.045416
12G.S3.06 8.001515
13G.S3.08 4.38375419
14G.s3h2.03 4.03357719
15G.H2.06 6.11714719
16G.H2.07 5.41167619
17G.H2.10 3.76875417
18G.h2s4.01 6.10214719
19G.S4.02 6.9125418
20G.S4.03 3.386577
21G.S4.04 5.34083619
22G.S4.06 4.755517
23G.s4h3.01 6.1875417
24G.s4h3.04 6.2375818
25G.s4h3.05 9.59419
26G.s4h3.08 3.55625408
27G.H3.01 6.5825409
28G.H3.02 2.711518
29G.H3.09 6.41286719
30G.H3.12 4.2025418
31G.H3.13 5.112515
32G.H3.17 6.94071715
33G.H3.18 5.82929719
34G.S5.02 5.179516
35G.S5.03 3.292578
36G.S5.04 5.071519
37G.S5.05 4.30667979
38G.S5.06 5.88125418
39G.S5.07 4.993579
40G.HG.04 4.85509
41G.HG.07 8.15419
42G.HG.15 6.1975417
43G.hgh4.01 6.28375416
44G.hgh4.02 6.23812817
45G.hgh4.05 5.839507
46G.H4.03 5.508504
47G.H4.10 9.34875416
48G.H4.11 3.49625417
49G.H4.15 5.01571718
50G.h4s6.02 5.59875418
51G.h4s6.10 4.07413
52G.h4s6.11 5.044517
53G.S6.01 5.3475415
54G.S6.02 5.656676107
55G.S6.05 4.02875414
56G.s6h5.01 5.65875479
57G.H5.03 4.34375478
58G.H5.08 5.205598
59G.H5.13 7.784108
60G.H5.17 5.881676105
61G.H5.20 5.35509
62G.H5.26 6.3395105
63b.1x1 1.5525404
64b.1x19 6.53406
65b.h2x1 4.68125405
66b.lhb1x3 4.767512
67b.lhb1x6 4.27613
68b.lhb1x9 3.89625413
69b.lhb1x11 4.325404
70b.b1x3 4.862517
71b.b1x6 8.483519
72b.l1x3 7.645719
73b.l1x6 12.7987419
74b.b2x1 6.28375418
75b.b2x3 3.571516
76b.b2x5 6.66167617
77b.b3x1 3.98875465
78b.b3x2 7.005415
79b.b3x3 4.205568
80b.b3x4 5.89125419
81b.l3x1 7.18419
82b.b4x2 6.0825408
83b.b4x3 4.549567
84b.b4x4 6.719518
85b.b4x5 4.617567
86b.b4x6 10.34719
87b.l4x2 12.4637414
88b.b5x2 4.654517
89b.b5x3 7.784519
90b.b5x5 4.728565
91b.b5x7 6.21375467
92b.l5x1 4.341568
93b.l5x5 7.68919
94b.b6x5 4.41666
95b.l6x5 6.365454
96b.b7x1 7.3475454
97b.b7x2 4.39875468
98b.b7x4 3.4775468
99b.l7x2 3.99929719
100b.l7x4 4.1375419
101b.b8x3 3.452556
102b.b8x4 5.48083666
103b.l8x1 4.672565
104b.l8x8 5.58125464
105b.b9x3 4.29625466
106b.l9x3 6.90938859
107b.l9x6 4.7875818
108b.l9x7 5.096557
109b.b10x3 3.84125458
110b.b10x5 3.55857759
111b.l10x1 3.774533
112b.b11x2 3.5375657
113b.b11x4 4.91333659
114b.b11x5 4.965536
115b.l11x2 8.2459
116b.b12x3 3.533538
117b.b12x5 3.446536
118b.b12x6 8.59286758
119b.b13x3 7.7675454
120b.b13x5 4.215434
121b.b13x7 8.19583637
122b.l13x3 7.93071739
123b.l13x6 5.516519
124b.l13x7 4.46539
125b.b14x3 5.498535
126b.b14x5 3.42435
127b.b15x1 6.76667639
128b.b15x2 7.0825446
129b.b15x3 3.94875439
130b.l15x1 5.012517
131b.l15x2 6.697539
132b.b16x4 9.667536
133b.b16x5 4.79125445
134b.b16x6 9.2175638
135b.b16x7 6.18125449
136b.b17x3 5.475435
137b.b17x4 4.88545
138b.b17x5 6.126547
139b.b17x7 7.459548
140b.l17x3 8.83286749
141b.l17x6 7.50375419
142b.l17x7 5.9375447
143b.b18x3 4.42548
144b.b18x5 4.621545
145b.l18x1 6.78786716
146b.l18x2 5.4675417
147b.b19x2 6.88688846
148b.b19x4 6.408548
149b.l19x1 5.8725419
150b.l19x2 4.94875449
151b.b20x2 4.683546
152b.b20x4 10.4492648
153b.b20x5 4.258517
154b.b20x6 6.44357746
155b.l20x1 3.2475446
156b.b21x1 11.2013447
157b.b21x4 5.54625405
158b.b21x5 5.9775414
159b.b21x7 6.31615
160b.l21x5 3.475414
161b.l21x7 4.15625415
162b.l21x9 5.44416
163b.b22x5 5.00167617
164b.l22x5 7.7475619
165b.b23x1 5.35375415
166b.b23x2 5.97375416
167b.b23x6 6.89643717
168b.l23x1 6.46875416
169b.l23x2 4.635418
170b.b24x4 7.8225416
171b.b24x6 5.385518
172b.l24x2 5.07516
173b.l24x3 5.92405
174b.b25x3 5.8125415
175b.b25x6 4.1125413
176b.l25x3 7.845689
177b.l25x6 9.297518
178b.l25x7 3.49375487
179b.b26x3 4.09406
180b.l26x5 4.93167615
181b.l27x1 10.7771719
182b.l27x2 5.81125489
183b.b28x2 4.3925484
184b.b28x3 4.39929717
185b.b28x4 6.822586
186b.b28x5 4.3415
187b.b28x6 8.21333689
188b.b28x7 4.12419
189g.h1x1 3.984122
190g.h1x11 3.526254149
191g.h2x11 11.9675416
192g.ctx3 5.19619
193g.ctx4 4.5375417
194g.ctx5 4.34875419
195g.ctx6 4.2275416
196g.ctx9 3.2725416
197g.ctx14 5.272519
198g.ctx15 7.4975419
199g.ctx16 5.07251018
2001x35 2.50375425
2011x46 2.99833608
2021x50 6.572509
2031x52 3.99875408
204I1x50 6.57375409
2052x37 6.4375428
2062x38 6.66375427
2072x39 5.76375428
2082x46 6.488529
2092x50 8.5529
2102x57 4.578529
211E1x50 6.609176119
212E1x52 6.58254117
2133x28 5.52125407
2143x34 4.94875407
2153x37 4.75625428
2163x40 5.271529
2173x41 4.06408
2183x43 5.22125428
2193x44 3.0525407
2203x49 6.596528
2213x50 6.615529
2223x51 5.63125408
223I2x53 7.41125828
2244x34 2.80375407
2254x50 4.68625409
2264x56 4.3825408
2274x61 4.79875408
228E2.N175 4.46875407
2295x39 7.2625408
2305x47 8.23214729
2315x48 5.406527
2325x50 3.4925409
2335x51 5.56625427
2345x54 4.28429
2355x58 6.24729
2365x68 8.131254108
2376x30 4.835109
2386x37 3.2275408
2396x44 5.6825629
2406x48 6.8025829
2416x51 7.102528
2426x52 8.65429728
2436x55 5.354528
2447x30 3.22625406
2457x34 5.8775425
2467x39 5.62188828
2477x42 5.36444928
2487x45 8.41125409
2497x49 9.03429
2507x52 3.24625428
2517x53 4.88937829
2528x50 10.8088409
253Lig 7.555711420
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b4x4 b.b4x6 16.212614.095YesYes189
2G.HN.47 b.b4x4 15.70682.85NoYes068
3G.HN.47 b.b4x2 15.20764.935NoYes068
4b.b4x2 b.b5x8 14.49284.185YesNo085
5b.b5x7 b.b5x8 14.17973.39YesNo075
6b.b5x5 b.l8x8 10.20464.845YesYes654
7b.l2x5 b.l4x2 10.70625.21NoYes154
8b.l26x5 g.ctx4 29.67257.55YesYes157
9g.ctx3 g.ctx4 31.47854.025YesYes197
10b.lhb1x11 g.ctx5 10.47584.945YesYes049
11b.b25x7 b.lhb1x11 57.88014.945NoYes074
12b.b25x7 b.b28x6 57.06821.07NoYes079
13b.b28x6 b.l25x3 56.3653.175YesYes899
14b.l25x3 b.l27x2 99.76335.04YesYes899
15b.l25x4 b.l27x2 1002.66NoYes059
16I1x48 b.l25x4 99.88053.455NoNo085
17I1x48 I1x51 99.76283.39NoNo088
182x41 I1x51 99.64417.89NoNo078
192x41 4x42 99.40623.155NoNo077
204x42 4x46 99.2873.07NoNo079
212x45 4x46 99.16766.97NoNo099
222x45 3x42 72.92878.94NoNo098
232x46 3x42 53.29226.18YesNo098
242x46 7x53 31.34192.93YesYes299
253x50 7x53 28.83337.2YesYes299
263x50 G.H5.23 17.08133.485YesNo294
27G.H5.23 I2x53 11.56085.375NoYes248
28b.l26x5 g.ctx16 21.91583.11YesYes158
29b.b3x2 b.b4x6 10.347.4YesYes159
30G.H2.09 G.H2.10 17.73942.95NoYes187
31b.b2x1 b.l27x1 17.48112.895YesYes189
32G.H2.10 b.l5x5 23.13062.61YesYes179
33b.l3x1 b.l5x5 15.79948.76YesYes199
343x50 G.H5.25 15.80677.895YesNo097
35G.H5.20 G.H5.25 17.32114.15YesNo097
36G.H5.20 G.H5.26 12.583814.005YesYes095
37G.H5.17 G.H5.26 10.48173.72YesYes1055
38G.H3.17 G.H3.18 25.74852.505YesYes159
39G.H3.12 G.H3.18 20.03485.65YesYes189
40G.H3.12 G.S4.04 19.84032.51YesYes189
41b.l23x1 b.l25x6 28.099212.505YesYes168
42b.l25x6 b.l27x1 34.138319.495YesYes189
43G.S4.04 G.S4.06 15.55823.275YesYes197
44G.H3.02 G.S4.06 10.51693.04YesYes187
45b.l22x3 g.ctx3 19.1219.57NoYes199
46b.l22x3 b.l22x4 19.04282.785NoNo199
47b.l18x1 b.l22x4 12.82914.52YesNo169
48b.b20x5 b.b22x5 13.00532.44YesYes177
49b.b20x5 b.b21x4 43.32035.535YesYes075
50b.b21x4 g.h2x1 96.90712.98YesNo058
51b.b21x2 g.h2x1 96.69783.585NoNo068
52b.1x19 b.b21x2 96.27868.18YesNo066
53g.ctx3 g.ctx6 12.12814.75YesYes196
54b.l22x5 g.ctx6 11.86516.075YesYes196
55b.l22x5 b.lhb1x3 27.82825.64YesYes192
56b.h2x5 b.lhb1x3 27.90244.56NoYes152
57b.h2x1 b.h2x5 55.58132.95YesNo055
58b.b21x4 b.h2x1 54.45254.845YesYes055
59b.l22x5 b.l24x2 27.75899.72YesYes196
60b.h2x5 b.l24x2 27.74133.685NoYes156
61b.1x19 b.b21x1 18.116411.32YesYes067
62b.1x19 g.h1x14 71.25593.49YesNo069
63b.l22x5 b.lhb1x6 44.10735.885YesYes193
64b.lhb1x11 b.lhb1x9 43.74964.37YesYes043
65b.b2x5 b.b3x2 10.296110.82YesYes175
66b.b26x4 b.b2x5 12.74952.81NoYes057
67b.b22x4 b.b26x4 13.02842.785NoNo055
68b.b22x4 b.b26x5 13.31874.85NoNo057
69b.b1x6 b.b4x6 10.884220.5YesYes199
70b.b1x6 b.b28x5 13.22846.425YesYes195
71b.b28x5 g.ctx16 14.42324.395YesYes158
72b.b17x6 g.h1x14 67.71978.47NoNo079
73b.b16x4 b.b17x6 43.005615.77YesNo367
74b.b16x4 b.b16x6 23.74558.7YesYes368
75b.b15x1 b.b16x6 38.019910.025YesYes398
76b.b14x3 b.b15x1 32.96243.655YesYes359
77b.b17x3 b.b17x6 24.48472.535YesNo357
78b.b16x6 b.b17x3 23.75935.225YesYes385
79b.l8x1 b.l8x8 12.83954.47YesYes654
80b.b16x4 b.l13x3 18.788113.1YesYes369
81b.l13x3 b.l13x7 16.55668.305YesYes399
82b.b11x5 b.l13x7 16.09395.655YesYes369
83b.b10x2 b.b11x5 15.67143.44NoYes366
84b.b10x2 b.b6x2 46.47722.535NoNo068
85b.b10x3 b.b6x2 45.72035.07YesNo088
86b.b10x3 b.b11x2 25.9133.275YesYes587
87b.b10x2 b.b14x3 31.56247.935NoYes365
88b.b8x4 b.l8x10 13.68435.68YesNo664
89b.b8x2 b.b8x4 13.66846.36NoYes086
90b.b8x2 b.b9x3 14.13422.875NoYes086
91b.b9x3 b.l8x10 14.13412.85YesNo664
92b.l5x3 b.l5x5 31.42812.47NoYes089
93b.l5x3 b.l7x3 30.86810.305NoNo089
94b.b9x3 b.l7x5 29.24782.735YesNo066
95b.l7x3 b.l7x5 30.31474.2NoNo096
96b.b11x2 b.b8x3 12.98413.68YesYes576
97b.b10x3 b.b11x4 16.00383.38YesYes589
98b.b17x7 b.b21x1 12.08744.78YesYes487
99b.b16x5 b.l20x1 10.56714.845YesYes456
100b.l21x7 b.l23x1 31.42155.445YesYes156
101b.b23x6 b.l21x7 29.96243.36YesYes175
102b.b20x5 b.b21x7 26.60987.03YesYes175
103b.b23x6 b.b24x6 27.97297.72YesYes178
104b.b22x1 b.l25x6 38.49376.47NoYes188
105b.b22x1 b.b22x2 42.38264NoNo088
106b.b26x3 b.b27x3 44.18284.42YesNo068
1072x46 2x50 18.33725.43YesYes299
1082x50 7x46 10.582311.78YesNo099
1097x42 Lig 10.92538.68YesYes280
1103x37 Lig 32.0153.285YesYes280
1113x37 3x41 16.44212.95YesYes088
1123x41 4x49 19.56634.47YesNo089
1133x42 4x49 19.74046.65NoNo089
1143x37 4x53 16.41243.2YesNo088
1153x38 4x53 16.44333.42NoNo088
1163x38 4x50 16.61755.835NoYes089
1172x45 4x50 26.62246.18NoYes099
118E2x52 Lig 11.94426.3NoYes070
1193x28 E1x50 12.57646.015YesYes079
120b.b27x3 b.l25x3 43.67128.895NoYes889
121b.b8x4 b.l8x8 17.85523.79YesYes664
122G.H3.17 b.l25x6 32.28715YesYes158
123b.b22x2 b.b26x3 42.32336.005NoYes086
124b.b21x7 b.b24x6 28.4129.16YesYes158
125b.lhb1x6 b.lhb1x9 43.47023.07YesYes133
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x537x422.520NoYes8821
2x563x325.842NoNo8821
2x567x422.5252NoYes8821
2x577x392.912YesYes9822
2x577x4210.182YesYes9821
2x607x395.5152NoYes8822
2x607x427.572NoYes8821
3x294x615.2150NoYes6822
3x29E2x523.840NoNo6721
3x327x427.4752NoYes8811
3x32Lig13.912NoYes8010
3x334x574.8450NoNo8912
3x334x613.7250NoYes8812
3x33Lig12.3650NoYes8010
3x366x485.222NoYes8912
3x367x422.692NoYes8811
3x36Lig5.052NoYes8010
3x373x412.952YesYes8812
3x374x533.22YesNo8812
3x375x4619.592YesNo8811
3x37Lig3.2852YesYes8010
3x405x472.512YesYes9922
3x406x4812.922YesYes9922
3x406x522.512YesYes9821
4x565x433.10YesNo8921
4x565x4616.9650YesNo8821
4x615x397.310YesYes8822
E2.N175E2x527.080YesNo0721
E2x51Lig6.8750NoYes5010
E2x52Lig6.30NoYes7010
5x395x435.9450YesNo8921
5x406x558.30NoYes7821
5x43Lig6.260NoYes9010
5x445x484.452NoYes8722
5x446x526.612NoYes8821
5x461Lig4.3052NoYes8010
5x475x486.192YesYes9722
5x476x484.012YesYes9922
5x476x5227.8652YesYes9821
5x486x523.092YesYes7821
6x486x527.522YesYes9821
6x517x385.842YesNo8811
6x51Lig14.422YesYes8010
6x52Lig8.162YesYes8010
6x556x593.9752YesNo8612
6x55Lig3.312YesYes8010
6x58E3.I40310.622NoNo5022
6x587x348.722NoYes5521
7x34E3.I4034.842YesNo5012
7x34Lig6.6852YesYes5010
7x387x423.7452NoYes8811
7x38Lig6.1752NoYes8010
7x397x422.8952YesYes8821
7x42Lig8.682YesYes8010
E2.E181E2x512.7350NoNo0521
6x486x512.5052YesYes9821
6x516x524.8252YesYes8811
6x516x557.922YesYes8811
6x557x343.2652YesYes8511

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
92.86Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
86.67Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
86.67Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
85.71Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
85.71Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
85.71Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
85.71Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
85.71Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
85.71Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
85.71Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
85.71Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
85.71Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
85.71Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
82.35Single4IARErgotamine4IAR-5-HT1B-Ergotamine
81.25Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
80.00Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
80.00Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
80.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
80.00Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
80.00Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
80.00Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
78.57Single6PS1Timolol6PS1-β2-Timolol
78.57Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
78.57Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
78.57Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
78.57Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
78.57Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
78.57Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
78.57Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
78.57Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
78.57Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
78.57Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
78.57Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
78.57Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
78.57Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
78.57Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
78.57Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
78.57Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
78.57Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
75.00Single3D4STimolol3D4S-β2-Timolol
75.00Single4AMIBucindolol4AMI-β1-Bucindolol
75.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
75.00Single6MXTSalmeterol6MXT-β2-Salmeterol
75.00Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
75.00Single8JJ8Formoterol8JJ8-β2-Formoterol
73.33Single2RH1S-Carazolol2RH1-β2-S-Carazolol
73.33Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
73.33Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
73.33Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
73.33Single7C61Ergotamine7C61-5-HT1B-Ergotamine
73.33Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
73.33Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
73.33Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
73.33Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
73.33Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
73.33Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
73.33Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
73.33Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
73.33Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
73.33Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
73.33Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
73.33Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
73.33Consensusamine_offonOrthosteric Ligandamine_off amine_on
73.33Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
73.33Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
73.33Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
73.33Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
73.33Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
73.33Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
72.22Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
72.22Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
71.43Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
71.43Single6PS0S-Carazolol6PS0-β2-S-Carazolol
71.43Single6PS4ICI118-5516PS4-β2-ICI118-551
71.43Single6PS5S-Propranolol6PS5-β2-S-Propranolol
71.43Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
71.43Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
71.43Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
71.43Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
71.43Single7UL3Famotidine7UL3-H2-Famotidine
71.43Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
71.43Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
71.43Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
71.43Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
71.43Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
71.43Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
71.43Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
71.43Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
71.43Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
71.43Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
71.43Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
71.43Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
71.43Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
71.43Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
71.43Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
71.43Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
71.43Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
71.43Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
71.43Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
71.43Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
71.43Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
71.43Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
70.59Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
70.59Single6IBLArformoterol6IBL-β1-Arformoterol
70.59Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
68.75Single3P0GBI1671073P0G-β2-BI167107
68.75Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
68.75Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
68.75Single5D5AS-Carazolol5D5A-β2-S-Carazolol
68.75Single5D5BS-Carazolol5D5B-β2-S-Carazolol
68.75Single6H7JIsoprenaline6H7J-β1-Isoprenaline
68.75Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
68.75Single6WGTLSD6WGT-5-HT2A-LSD
68.75Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
68.75Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
68.75Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
68.75Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
68.75Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
68.75Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
68.75Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
68.75Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
68.75Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
68.75Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
68.75Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
66.67Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
66.67Single2Y02Carmoterol2Y02-β1-Carmoterol
66.67Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
66.67Single3NY8ICI118-5513NY8-β2-ICI118-551
66.67Single3NY9ICI118-5513NY9-β2-ICI118-551
66.67Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
66.67Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
66.67Single4GBRS-Carazolol4GBR-β2-S-Carazolol
66.67Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
66.67Single6H7MSalbutamol6H7M-β1-Salbutamol
66.67Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
66.67Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
66.67Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
66.67Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
66.67Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
66.67Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
66.67Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
66.67Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
66.67Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
66.67Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
66.67Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
66.67Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
66.67Single8JJOAlprenolol8JJO-β2-Alprenolol
66.67Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
66.67Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
66.67Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
66.67Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
66.67Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
66.67Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
66.67Consensus5ht5_onOrthosteric Ligand5ht5a_on
66.67Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
66.67Consensusalpha2_onOrthosteric Ligandalpha2b_on
66.67Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
66.67Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
66.67Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
66.67Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
66.67Consensusdopamine_offOrthosteric Ligandd2_off d3_off
64.71Single4LDEBI1671074LDE-β2-BI167107
64.71Single4RWADIPP-NH24RWA-δ-DIPP-NH2
64.71Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
64.71Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
64.71Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
64.71Single8JJLOlodaterol8JJL-β2-Olodaterol
64.71Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
64.71Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
64.71Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
64.71Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
64.29Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
64.29Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
64.29Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
64.29Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
64.29Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
64.29Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
64.29Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
64.29Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
64.29Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
64.29Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
64.29Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
64.29Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
64.29Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
64.29Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
64.29Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
64.29Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
64.29Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
64.29Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
64.29Consensusalpha2_offOrthosteric Ligandalpha2c_off
64.29Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
64.29Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
64.29Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
63.16Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
63.16Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
63.16Single8WDTphotoNECA8WDT-A2A-photoNECA
62.50Single2Y03Isoprenaline2Y03-β1-Isoprenaline
62.50Single2YCWS-Carazolol2YCW-β1-S-Carazolol
62.50Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
62.50Single5C1MBU725C1M-μ-BU72
62.50Single5D6LS-Carazolol5D6L-β2-S-Carazolol
62.50Single5JQHS-Carazolol5JQH-β2-S-Carazolol
62.50Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
62.50Single6E67BI1671076E67-β2-BI167107-Gs (fused)
62.50Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
62.50Single7WC6LSD7WC6-5-HT2A-LSD
62.50Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
62.50Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
62.50Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
62.50Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
62.50Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
62.50Consensustrace-amine_onOrthosteric Ligandta1_on
61.11Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
61.11Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
61.11Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
61.11Single6H7LDobutamine6H7L-β1-Dobutamine
61.11Single7UM4AS26747237UM4-5-HT5A-AS2674723
61.11Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
61.11Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
61.11Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
61.11Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
61.11Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
60.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
60.00Single6KUXRS-799486KUX-α2a-RS-79948
60.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
60.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
60.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
60.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
60.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
60.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
60.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
60.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
60.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
60.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
60.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
60.00Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
60.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
60.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
60.00Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
60.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
60.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
60.00Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
60.00Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
60.00Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
58.82Single2YDVNECA2YDV-A2A-NECA
58.82Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
58.82Single4U15Tiotropium4U15-M3-Tiotropium
58.82Single4UHRCGS216804UHR-A2A-CGS21680
58.82Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
58.82Single5G53NECA5G53-A2A-NECA-Gs
58.82Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
58.82Single6OL9Tiotropium6OL9-M5-Tiotropium
58.82Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
58.82Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
58.82Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
58.82Single8E0GBU728E0G-μ-BU72
58.82Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
58.82Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
58.82Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
58.82Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
58.82Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
58.82Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
57.89Single4UG2CGS216804UG2-A2A-CGS21680
57.89Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
57.14Single3PBLEticlopride3PBL-D3-Eticlopride
57.14Single5WF5UK-4320975WF5-A2A-UK-432097
57.14Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
57.14Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
57.14Single7SRQLSD7SRQ-5-HT2B-LSD
57.14Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
57.14Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
57.14Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
57.14Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
57.14Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
57.14Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
57.14Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
57.14Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
57.14Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
56.25Single2Y04Salbutamol2Y04-β1-Salbutamol
56.25Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
56.25Single4QKX35V4QKX-β2-35V
56.25Single7BU7BI1671077BU7-β1-BI167107
56.25Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
56.25Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
56.25Single7WC7Lisuride7WC7-5-HT2A-Lisuride
56.25Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
56.25Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
56.25Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
56.25Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
56.25Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
56.25Single8JXRLSD8JXR-D1-LSD
56.25Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
56.25Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
56.25Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
56.25Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
56.25Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
56.25Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
56.25Single8X64Desloratadine8X64-H1-Desloratadine
56.25Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
56.25Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
56.25Single9CHXS-Carazolol9CHX-β2-S-Carazolol
56.25Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
56.25Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
56.25Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
56.25Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
56.25Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
55.56Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
55.56Single5CXVTiotropium5CXV-M1-Tiotropium
55.56Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
55.56Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
55.56Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
55.56Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
55.56Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
55.56Single7YITNalfurafine7YIT-κ-Nalfurafine
55.56Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
55.56Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
55.56Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
55.56Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
55.56Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
55.56Consensusalpha1_offOrthosteric Ligandalpha1a_off
55.56Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
55.56Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
55.56Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
55.56Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
55.56Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
55.56Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
55.56Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
55.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
55.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
55.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
55.00Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
53.33Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
53.33Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
53.33Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
53.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
53.33Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
53.33Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
53.33Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
53.33Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
53.33Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
53.33Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
53.33Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
53.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
53.33Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
52.94Single5TVNLSD5TVN-5-HT2B-LSD
52.94Single5WIUNemonapride5WIU-D4-Nemonapride
52.94Single5WIVNemonapride5WIV-D4-Nemonapride-Na
52.94Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
52.94Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
52.94Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
52.94Single6PS6Timolol6PS6-β2-Timolol
52.94Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
52.94Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
52.94Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
52.94Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
52.94Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
52.94Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
52.94Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
52.94Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
52.94Consensusa3_on_gpOrthosteric Liganda3a_on_gp
52.94Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
52.94Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
52.94Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
52.94Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
52.94Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
52.63Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
52.63Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
52.63Single7EZCUKA7EZC-A2A-UKA
52.63Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
52.63Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
52.63Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
52.63Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
52.63Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
52.63Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
52.63Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
52.63Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
52.38Single3QAKUK-4320973QAK-A2A-UK-432097
50.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
50.00Single3RZECidoxepin3RZE-H1-Cidoxepin
50.00Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
50.00Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
50.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
50.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
50.00Single5WF6UK-4320975WF6-A2A-UK-432097
50.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
50.00Single6A94Zotepine6A94-5-HT2A-Zotepine
50.00Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
50.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
50.00Single6J21Aprepitant6J21-NK1-Aprepitant
50.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
50.00Single6PT3DPI-2876PT3-δ-DPI-287
50.00Single6TPGEMPA6TPG-OX2-EMPA
50.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
50.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
50.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
50.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
50.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
50.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
50.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
50.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
50.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
50.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
50.00Single7XN9L-054,5227XN9-SST2-L-054,522
50.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
50.00Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
50.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
50.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
50.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
50.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
50.00Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
50.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
50.00Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
50.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
50.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
50.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
50.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single8X5YAstemizole8X5Y-H1-Astemizole
50.00Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
50.00Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
50.00Single9BJKNaloxone9BJK-μ-Naloxone-NAM
50.00Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
50.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
50.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
50.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
50.00Consensusa2_onOrthosteric Liganda2b_on
50.00Consensusa2_on_gpOrthosteric Liganda2b_on_gp
50.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
50.00Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
50.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
50.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
50.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
50.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
50.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
50.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
50.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
50.00Consensustachykinin_offOrthosteric Ligandnk1_off
47.83Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
47.83Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
47.62Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
47.62Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
47.62Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
47.62Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
47.37Single6A93Risperidone6A93-5-HT2A-Risperidone
47.37Single6CM4Risperidone6CM4-D2-Risperidone
47.37Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
47.37Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
47.37Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
47.37Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
47.37Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
47.37Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
47.37Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
47.37Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
47.37Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
47.06Single2Y01Dobutamine2Y01-β1-Dobutamine
47.06Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
47.06Single4EJ4Naltrindole4EJ4-δ-Naltrindole
47.06Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
47.06Single4MQSIperoxo4MQS-M2-Iperoxo
47.06Single4U14Tiotropium4U14-M3-Tiotropium
47.06Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
47.06Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
47.06Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
47.06Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
47.06Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
47.06Single6DRXLisuride6DRX-5-HT2B-Lisuride
47.06Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.06Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
47.06Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
47.06Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
47.06Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
47.06Single7UL4Alvimopan7UL4-μ-Alvimopan
47.06Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
47.06Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
47.06Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
47.06Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
47.06Single8X63Mepyramine8X63-H1-Mepyramine
47.06Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
47.06Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
47.06Consensusa3_onOrthosteric Liganda3a_on
47.06Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
47.06Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
47.06Consensushistamine_offOrthosteric Ligandh1_off
47.06Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
47.06Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
46.67Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
46.67Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
46.67Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.67Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
46.67Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
46.67Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
46.67Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
46.67Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
46.67Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
46.67Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
46.67Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
46.67Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
46.67Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
45.83Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
45.45Single6HLOAprepitant6HLO-NK1-Aprepitant
45.45Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
45.45Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
45.00Single5X93K-87945X93-ETB-K-8794
45.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
45.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
45.00Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
45.00Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.00Consensusendothelin_offOrthosteric Ligandetb_off
45.00Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
45.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
45.00Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
44.44Single2Y00Dobutamine2Y00-β1-Dobutamine
44.44Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
44.44Single5WQCEMPA5WQC-OX2-EMPA
44.44Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
44.44Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
44.44Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
44.44Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
44.44Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
44.44Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
44.44Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
44.44Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
44.44Single8JXSPF-61428JXS-D1-PF-6142
44.44Single8ZMFA1L108ZMF-5-HT2C-A1L10
44.44Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
44.44Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
44.44Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
44.44Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
43.75Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
43.75Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
43.75Single6AKXA4R6AKX-CCR5-A4R
43.75Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
43.75Single6TODEMPA6TOD-OX1-EMPA-Na
43.75Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
43.75Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
43.75Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
43.75Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
43.75Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
43.75Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
43.75Single8GNGIstradefylline8GNG-A2A-Istradefylline
43.75Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
43.75Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
43.75Single8IWESpermidine8IWE-TA9-Spermidine
43.75Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
43.75Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
43.75Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
43.75Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
43.75Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
43.75Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
43.48Single6PT2KGCHM076PT2-δ-KGCHM07
43.48Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
43.48Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
43.48Consensusangiotensin_onOrthosteric Ligandat1_on
43.48Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
43.48Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
43.48Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
43.48Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
42.86Single7SK9CCX6627SK9-ACKR3-CCX662
42.86Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
42.86Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
42.86Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
42.86Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
42.86Single9CHUNoradrenaline9CHU-β2-Noradrenaline
42.86Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
42.86Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
42.86Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
42.86Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
42.31Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
42.31Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
42.31Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
42.11Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
42.11Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
42.11Single6J20Aprepitant6J20-NK1-Aprepitant
42.11Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
42.11Single7B6WCyclazosin7B6W-α1b-Cyclazosin
42.11Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
42.11Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
42.11Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
42.11Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
42.11Single8EA0Iperoxo8EA0-M3-Iperoxo
42.11Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
42.11Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
42.11Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
42.11Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
42.11Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
42.11Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
42.11Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
42.11Single8XVLZibotentan8XVL-ETA-Zibotentan
42.11Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
42.11Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
42.11Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
42.11Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
42.11Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
41.67Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
41.67Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
41.67Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
41.67Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
41.67Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
41.67Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
41.67Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
41.18Single2YDOAdenosine2YDO-A2A-Adenosine
41.18Single4MBSMaraviroc4MBS-CCR5-Maraviroc
41.18Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
41.18Single4ZJCSB-6740424ZJC-OX1-SB-674042
41.18Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
41.18Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
41.18Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
41.18Single6TPNHTL66416TPN-OX2-HTL6641
41.18Single6VI4JDTic6VI4-κ-JDTic
41.18Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
41.18Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
41.18Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
41.18Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
41.18Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
41.18Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
41.18Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
41.18Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
41.18Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
41.18Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
41.18Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
40.91Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
40.91Single7F8XNN90567F8X-CCKA-NN9056
40.91Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
40.91Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
40.91Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
40.91Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
40.91Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
40.00Single3UZAGTPL92363UZA-A2A-GTPL9236
40.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
40.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
40.00Single7DFPSpiperone7DFP-D2-Spiperone
40.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
40.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
40.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
40.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
40.00Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
40.00Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
40.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
40.00Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
40.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
40.00Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
40.00Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
40.00Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
40.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
40.00Consensus5ht2_onOrthosteric Ligand5ht2b_on
40.00Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
40.00Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
40.00Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
40.00Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
40.00Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
40.00Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
40.00Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
40.00Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
40.00Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
39.13Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
39.13Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
39.13Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
39.13Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
39.13Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
39.13Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
39.13Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
39.13Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
38.89Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
38.89Single4DAJTiotropium4DAJ-M3-Tiotropium
38.89Single5DHGC-355DHG-NOP-C-35
38.89Single5DHHSB-6121115DHH-NOP-SB-612111
38.89Single5DSGTiotropium5DSG-M4-Tiotropium
38.89Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
38.89Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
38.89Single5UIGCmpd-15UIG-A2A-Cmpd-1
38.89Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
38.89Single6TOTLemborexant6TOT-OX1-Lemborexant
38.89Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
38.89Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
38.89Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
38.89Single8CU6LJ-45178CU6-A2A-LJ-4517
38.89Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
38.89Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
38.89Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
38.89Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
38.89Single8T1WCVN4248T1W-GPR6-CVN424
38.89Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
38.89Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
38.89Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
38.89Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
38.46Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
38.46Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
38.46Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
38.46Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
38.10Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
38.10Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
38.10Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
38.10Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
38.10Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
38.10Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.10Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
38.10Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
38.10Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
38.10Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.10Consensuscck_onOrthosteric Ligandccka_on cckb_on
38.10Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
38.10Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
38.10Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
37.50Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
37.50Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
37.50Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
37.50Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
37.50Single6HLLCP999946HLL-NK1-CP99994
37.50Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
37.50Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
37.50Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
37.50Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.50Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
37.50Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
37.50Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
37.50Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
37.50Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
37.50Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
37.04Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
37.04Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
37.04Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
37.04Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
36.84Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
36.84Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
36.84Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
36.84Single5XPRBosentan5XPR-ETB-Bosentan
36.84Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
36.84Single6HLPNetupitant6HLP-NK1-Netupitant
36.84Single6LUQHaloperidol6LUQ-D2-Haloperidol
36.84Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
36.84Single6TP6Filorexant6TP6-OX1-Filorexant
36.84Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
36.84Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
36.84Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
36.84Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
36.84Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
36.84Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
36.84Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
36.84Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
36.84Single8S4DCMF-0198S4D-Apelin-CMF-019
36.84Single8TF5Oleic acid8TF5-GPR6-Oleic acid
36.84Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
36.84Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
36.84Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
36.84Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Consensusadenosine_offOrthosteric Liganda1_off a2_off
36.84Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
36.84Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
36.36Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
36.36Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
36.36Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
36.36Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
36.36Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
36.36Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
36.36Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
36.36Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
36.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
36.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
36.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.00Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
36.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
36.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
36.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
36.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
36.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
36.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
35.71Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
35.71Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
35.71Consensusbradykinin_onOrthosteric Ligandbk2_on
35.71Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
35.71Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
35.29Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
35.29Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
35.29Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
35.29Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
35.29Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
35.29Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
35.29Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
35.29Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
35.29Single5WS3EMPA5WS3-OX2-EMPA
35.29Single6AKYMaraviroc6AKY-CCR5-Maraviroc
35.29Single6B73MP11046B73-κ-MP1104
35.29Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
35.29Single6DS0Ly2660976DS0-5-HT2B-Ly266097
35.29Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
35.29Single6ME2Ramelteon6ME2-MT1-Ramelteon
35.29Single6ME9Ramelteon6ME9-MT2-Ramelteon
35.29Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
35.29Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
35.29Single7F8ULintitript7F8U-CCKA-Lintitript
35.29Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
35.29Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
35.29Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
35.29Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
35.29Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
35.29Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
35.29Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
35.29Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
35.29Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
35.29Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
35.29Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
35.29Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
35.29Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
35.29Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
35.29Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
35.29Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
35.29Consensusorexin_offOrthosteric Ligandox2_off ox1_off
35.29Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
35.29Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
35.29Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
35.29Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
35.00Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
35.00Single4DJHJDTic4DJH-κ-JDTic
35.00Single6E59L-7607356E59-NK1-L-760735
35.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
35.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
35.00Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
35.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
35.00Single7PX4PSB-21137PX4-A2A-PSB-2113
35.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
35.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
35.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
35.00Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
35.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
35.00Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
35.00Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
35.00Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
35.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
35.00Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
35.00Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
35.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
34.78Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
34.78Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
34.78Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
34.78Consensuslpl_onOrthosteric Ligands1p_on lpa_on
34.78Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
34.62Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
34.62Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
34.62Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
34.62Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
33.33Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
33.33Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
33.33Single3REYXAC3REY-A2A-XAC
33.33Single3RFMCaffeine3RFM-A2A-Caffeine
33.33Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
33.33Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
33.33Single5IU7Q274563465IU7-A2A-Q27456346-Na
33.33Single5IUBQ274563445IUB-A2A-Q27456344-Na
33.33Single5JTBZM-2413855JTB-A2A-ZM-241385
33.33Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
33.33Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
33.33Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
33.33Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
33.33Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
33.33Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
33.33Single6AQFZM-2413856AQF-A2A-ZM-241385
33.33Single6IQLL7458706IQL-D4-L745870
33.33Single6MH8ZM-2413856MH8-A2A-ZM-241385
33.33Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
33.33Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
33.33Single6V9SGTPL114036V9S-OX1-GTPL11403
33.33Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
33.33Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
33.33Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
33.33Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
33.33Single7AROLUF58337ARO-A2A-LUF5833-Na
33.33Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
33.33Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
33.33Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
33.33Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
33.33Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
33.33Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
33.33Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
33.33Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
33.33Single7T32ZM-2413857T32-A2A-ZM-241385
33.33Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
33.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
33.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
33.33Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
33.33Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
33.33Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
33.33Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
33.33Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
33.33Single8A2OTheophylline8A2O-A2A-Theophylline-Na
33.33Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
33.33Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
33.33Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
33.33Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
33.33Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
33.33Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
33.33Single8JWY2-1188JWY-A2A-2-118
33.33Single8JWZAB9288JWZ-A2A-AB928-Na
33.33Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
33.33Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
33.33Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
33.33Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
33.33Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
33.33Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
33.33Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
33.33Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
33.33Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
33.33Single8XYIVUF106618XYI-CXCR3-VUF10661
33.33Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
33.33Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
33.33Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
33.33Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
33.33Consensusa2_offOrthosteric Liganda2a_off
33.33Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
33.33Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
33.33Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
33.33Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
33.33Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
33.33Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
33.33Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
33.33Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
33.33Consensushca_onOrthosteric Ligandhca2_on
33.33Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
33.33Consensuslpa_offOrthosteric Ligandlpa1_off
33.33Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
33.33Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
33.33Consensusopsins_offOrthosteric Ligandrhodopsin_off
33.33Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
33.33Consensusorexin_onOrthosteric Ligandox2_on
33.33Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
33.33Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
33.33Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
33.33Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
33.33Consensussensory_offOrthosteric Ligandopsins_off
33.33Consensussensory_onOrthosteric Ligandopsins_on
32.26Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
32.14Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
32.14Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
32.14Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
32.14Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
32.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
32.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
32.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
32.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
32.00Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
32.00Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
32.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
31.82Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
31.82Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
31.82Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
31.82Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
31.82Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
31.82Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
31.82Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
31.82Single8XVJMacitentan8XVJ-ETA-Macitentan
31.82Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
31.82Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
31.82Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
31.82Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
31.82Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
31.82Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
31.82Consensuschemerin_onOrthosteric Ligandcml1_on
31.82Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
31.82Consensusprostanoid_offOrthosteric Ligandep_off dp_off
31.58Single3EMLZM-2413853EML-A2A-ZM-241385
31.58Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
31.58Single5IU8Q274563475IU8-A2A-Q27456347-Na
31.58Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
31.58Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
31.58Single5UENDU1725UEN-A1-DU172
31.58Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
31.58Single6D27CAY104716D27-DP2-CAY10471
31.58Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
31.58Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
31.58Single6S0LZM-2413856S0L-A2A-ZM-241385
31.58Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
31.58Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
31.58Single7PYRPSB-21157PYR-A2A-PSB-2115
31.58Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
31.58Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
31.58Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
31.58Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
31.58Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
31.58Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
31.58Single8K5DGSK2560738K5D-HCA2-GSK256073
31.58Single8RLNLUF58348RLN-A2A-LUF5834
31.58Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
31.58Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
31.58Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
31.58Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
31.58Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
31.58Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
31.58Consensusblt_onOrthosteric Ligandblt1_on
31.58Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
31.58Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
31.58Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
31.58Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
31.58Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
31.58Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
31.58Consensushca_on_gpOrthosteric Ligandhca2_on_gp
31.58Consensusleukotriene_onOrthosteric Ligandblt_on
31.58Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
31.58Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
31.58Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
31.25Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
31.25Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
31.25Single6ME5Agomelatine6ME5-MT1-Agomelatine
31.25Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
31.25Single7WC5Psilocin7WC5-5-HT2A-Psilocin
31.25Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.25Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
31.25Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
31.25Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
31.25Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
31.25Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
31.25Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
31.03Single6IGLIRL16206IGL-ETB-IRL1620
31.03Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
31.03Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
31.03Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
30.77Single6JODAngiotensin II6JOD-AT2-Angiotensin II
30.77Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
30.77Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
30.77Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
30.77Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
30.77Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
30.77Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
30.43Single5ZTYAM102575ZTY-CB2-AM10257
30.43Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
30.43Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
30.43Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
30.43Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
30.43Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
30.43Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
30.43Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
30.43Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
30.43Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
30.43Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
30.43Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
30.43Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
30.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
30.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
30.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
30.00Single5N2RPSB-365N2R-A2A-PSB-36-Na
30.00Single5N2SPSB365N2S-A1-PSB36
30.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
30.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
30.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
30.00Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
30.00Single6S0QZM-2413856S0Q-A2A-ZM-241385
30.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
30.00Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
30.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
30.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
30.00Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
30.00Single7SINNPS-21437SIN-CaS-NPS-2143
30.00Single7SINNPS-21437SIN-CaS-NPS-2143
30.00Single7W41PD1762527W41-BB2-PD176252
30.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
30.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
30.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
30.00Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
30.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
30.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
30.00Single8QOTNanobody-E8QOT-μ-Nanobody-E
30.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
30.00Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
30.00Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
30.00Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
30.00Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
30.00Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
30.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
30.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
30.00Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
30.00Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
30.00Consensusbombesin_offOrthosteric Ligandbb2_off
30.00Consensusbombesin_onOrthosteric Ligandbb2_on
30.00Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
30.00Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
30.00Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
30.00Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
30.00Consensusdp_offOrthosteric Liganddp2_off
30.00Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
30.00Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
30.00Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
30.00Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
30.00Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
29.63Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
29.63Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
29.63Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
29.63Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
29.63Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.63Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
29.63Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
29.41Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
29.41Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
29.41Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
29.41Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
29.41Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
29.41Single6TP4ACT-4622066TP4-OX1-ACT-462206
29.41Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
29.41Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
29.41Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
29.41Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
29.41Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
29.41Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
29.41Single8K5BNiacin8K5B-HCA2-Niacin
29.41Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
29.41Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
29.41Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
29.41Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
29.17Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
29.17Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
29.17Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
29.17Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
29.17Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.17Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
29.17Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
29.17Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
29.17Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
29.17Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.03Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
28.57Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
28.57Single5MZPCaffeine5MZP-A2A-Caffeine-Na
28.57Single5XR8AM8415XR8-CB1-AM841
28.57Single5XRAAM115425XRA-CB1-AM11542
28.57Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
28.57Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
28.57Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
28.57Single7TUYGSK682753A7TUY-GPR183-GSK682753A
28.57Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
28.57Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
28.57Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
28.57Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
28.57Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
28.57Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
28.57Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
28.57Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
28.57Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
28.57Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
28.57Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
28.57Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
28.57Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
28.57Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
28.57Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
28.57Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
28.12Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
28.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
28.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
28.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
28.00Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
28.00Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
28.00Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
28.00Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
28.00Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
28.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
27.78Single3PWHZM-2413853PWH-A2A-ZM-241385
27.78Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
27.78Single4S0VSuvorexant4S0V-OX2-Suvorexant
27.78Single6TPJSuvorexant6TPJ-OX2-Suvorexant
27.78Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
27.78Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
27.78Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
27.78Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
27.78Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
27.78Single7XRRLemborexant7XRR-OX2-Lemborexant
27.78Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
27.78Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
27.78Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
27.78Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
27.78Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
27.78Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
27.78Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
27.78Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
27.78Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
27.78Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
27.78Single8Y0HVUF114188Y0H-CXCR3-VUF11418
27.78Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
27.78Consensusangiotensin_offOrthosteric Ligandat1_off
27.78Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
27.78Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
27.78Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
27.59Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
27.59Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
27.59Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
27.59Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
27.27Single4N4WSANT-14N4W-SMO-SANT-1
27.27Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
27.27Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
27.27Single7K15MKD0467K15-BLT1-MKD046-Na
27.27Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
27.27Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
27.27Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
27.27Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
27.27Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
27.27Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
27.27Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
27.27Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
27.27Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
27.27Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
27.27Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
27.27Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
27.27Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
27.27Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
27.27Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
27.27Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
27.27Consensuslpl_offOrthosteric Ligands1p_off lpa_off
26.92Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
26.92Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
26.92Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
26.92Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
26.92Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
26.92Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
26.92Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
26.92Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
26.67Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
26.67Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
26.67Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
26.67Single7WC4Serotonin7WC4-5-HT2A-Serotonin
26.67Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
26.67Single8PWNTheophylline8PWN-A2A-Theophylline
26.67Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
26.67Consensusendothelin_onOrthosteric Ligandetb_on eta_on
26.67Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
26.32Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
26.32Single5UVIZM-2413855UVI-A2A-ZM-241385
26.32Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
26.32Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
26.32Single6TP3Nemorexant6TP3-OX1-Nemorexant
26.32Single7VODCariprazine7VOD-5-HT2A-Cariprazine
26.32Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
26.32Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
26.32Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.32Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
26.32Single8IHKAcifran8IHK-HCA3-Acifran
26.32Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
26.32Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.32Single8K5CAcipimox8K5C-HCA2-Acipimox
26.32Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
26.32Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
26.32Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
26.32Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
26.32Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
26.09Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.09Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
26.09Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
26.09Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
26.09Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
26.09Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
26.09Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
26.09Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
26.09Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
26.09Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
25.93Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
25.93Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
25.93Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
25.93Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
25.93Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.93Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
25.93Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
25.93Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
25.93Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
25.81Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
25.81Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
25.00Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
25.00Single4YAYZD-71554YAY-AT1-ZD-7155
25.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
25.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
25.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
25.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
25.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
25.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
25.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
25.00Single7V3ZCP559407V3Z-CB1-CP55940
25.00Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
25.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
25.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
25.00Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
25.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
25.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
25.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
25.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
25.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
25.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
25.00Single8QJ2pN1628QJ2-MC4-pN162-Gs
25.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
25.00Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
25.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
25.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
25.00Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
25.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
25.00Single8ZRTET-18ZRT-ETB-ET-1
25.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
25.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
25.00Consensuscck_offOrthosteric Ligandccka_off
25.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
25.00Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
25.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
25.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
25.00Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
24.14Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
24.00Single4XT1Fractalkine4XT1-US28-Fractalkine
24.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
24.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
24.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
24.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
24.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
24.00Single8IEBA1LYA8IEB-GPR156-A1LYA
24.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
24.00Single8WKYPG-9348WKY-MC4-PG-934
24.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
24.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
24.00Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
24.00Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
24.00Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single5CGCHTL142425CGC-mGlu5-HTL14242
23.81Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
23.81Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
23.81Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
23.81Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
23.81Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
23.81Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
23.81Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.81Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
23.81Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
23.81Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
23.81Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
23.81Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
23.81Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
23.81Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
23.81Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
23.81Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.81Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.81Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
23.81Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
23.53Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
23.53Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
23.53Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
23.53Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
23.53Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
23.53Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
23.53Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
23.53Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
23.53Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
23.53Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
23.53Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
23.53Consensusgi_sensoryOrthosteric Ligandgi_opsins
23.53Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
23.53Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
23.33Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
23.33Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
23.33Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
23.08Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
23.08Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
23.08Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
23.08Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
23.08Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
23.08Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
23.08Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
23.08Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
22.73Single5TZRMK86665TZR-FFA1-MK8666
22.73Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
22.73Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
22.73Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
22.73Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
22.73Single7FEECP559407FEE-CB1-CP55940-ZCZ011
22.73Single7R0CAVP7R0C-V2-AVP-Arrestin2
22.73Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
22.73Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
22.73Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
22.73Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
22.73Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
22.73Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
22.73Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
22.73Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
22.73Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
22.73Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
22.73Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
22.73Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
22.73Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
22.73Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
22.73Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
22.73Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
22.73Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
22.73Consensuslpa_onOrthosteric Ligandlpa1_on
22.73Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
22.73Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
22.73Consensusrelaxin_onOrthosteric Ligandrxfp4_on
22.73Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
22.58Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
22.58Single8IY6Endothelin-18IY6-ETB-Endothelin-1
22.22Single3OE0CVX153OE0-CXCR4-CVX15
22.22Single3OE9IT1t3OE9-CXCR4-IT1t
22.22Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
22.22Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
22.22Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
22.22Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
22.22Single6W25SHU91196W25-MC4-SHU9119-Ca
22.22Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
22.22Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
22.22Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
22.22Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
22.22Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
22.22Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
22.22Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
22.22Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
22.22Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
22.22Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
22.22Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
21.88Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
21.88Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
21.74Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
21.74Single6KQICP559406KQI-CB1-CP55940-Org27569
21.74Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
21.74Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
21.74Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
21.74Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
21.74Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
21.74Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
21.74Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
21.74Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
21.43Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
21.43Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
21.43Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
21.43Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
21.43Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
21.43Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
21.43Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
21.43Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
21.21Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
21.21Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
21.21Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
21.05Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
21.05Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
21.05Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
21.05Single7BR3Elagolix7BR3-GnRH1-Elagolix
21.05Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
21.05Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
21.05Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
21.05Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
21.05Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
21.05Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
21.05Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
21.05Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
20.83Single5CGDHTL142425CGD-mGlu5-HTL14242
20.83Single6K1QIRL25006K1Q-ETB-IRL2500
20.83Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
20.83Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
20.83Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
20.83Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
20.83Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
20.83Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
20.69Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
20.69Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
20.69Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
20.69Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
20.69Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
20.69Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
20.69Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
20.69Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
20.69Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
20.69Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
20.69Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
20.00Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
20.00Single4XT3Fractalkine4XT3-US28-Fractalkine
20.00Single5EE7MK08935EE7-Glucagon-MK0893
20.00Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
20.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
20.00Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
20.00Single6FJ3PTH6FJ3-PTH1-PTH
20.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
20.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
20.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
20.00Single6TPKRetosiban6TPK-OT-Retosiban
20.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
20.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
20.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
20.00Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
20.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
20.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
20.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
20.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
20.00Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
20.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
20.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
20.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
20.00Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
20.00Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
20.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
20.00Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
20.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
20.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
20.00Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
20.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
20.00Consensusgrh_offOrthosteric Ligandgnrh1_off
20.00Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.00Consensuskisspeptin_onOrthosteric Ligandkiss1_on
20.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
20.00Consensusvasop-oxy_offOrthosteric Ligandot_off
19.35Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
19.35Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
19.23Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
19.23Single7QA8Peptide7QA8-STE2-Peptide
19.23Single7QA8Peptide7QA8-STE2-Peptide
19.23Single8IEIA1LYA8IEI-GPR156-A1LYA
19.23Single8IEPA1LYA8IEP-GPR156-A1LYA
19.23Single8IEPA1LYA8IEP-GPR156-A1LYA
19.23Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
19.23Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
19.23Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
19.23Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
19.23Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
19.23Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
19.23Consensussomatostatin_offOrthosteric Ligandsst2_off
19.05Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
19.05Single5TGZAM65385TGZ-CB1-AM6538
19.05Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
19.05Single6GPSMK08126GPS-CCR2-MK0812
19.05Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
19.05Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
19.05Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
19.05Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
19.05Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.05Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
19.05Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
18.92Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
18.92Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
18.75Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
18.75Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
18.75Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
18.75Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
18.75Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
18.75Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
18.75Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
18.52Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
18.52Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
18.52Single7SK5CXCL127SK5-ACKR3-CXCL12
18.52Single7XNACYN1548067XNA-SST2-CYN154806
18.52Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single8IEBA1LYA8IEB-GPR156-A1LYA
18.52Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
18.52Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
18.52Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
18.52Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
18.52Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
18.42Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
18.18Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
18.18Single6GPXMK08126GPX-CCR2-MK0812
18.18Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
18.18Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
18.18Single7C4SS1P7C4S-S1P3-S1P
18.18Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
18.18Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
18.18Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
18.18Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
18.18Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
18.18Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
18.18Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
18.18Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
18.18Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
18.18Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
18.18Consensusblt_offOrthosteric Ligandblt1_off
18.18Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
18.18Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
17.86Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
17.86Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
17.86Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
17.86Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
17.86Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
17.86Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
17.86Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
17.65Single6TQ9SB-4081246TQ9-OX1-SB-408124
17.65Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
17.65Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
17.65Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
17.39Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
17.39Single7F1TMIP-1a7F1T-CCR5-MIP-1a
17.39Single7P2L4YI7P2L-mGlu5-4YI
17.39Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
17.39Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
17.39Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
17.39Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
17.39Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
17.39Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
17.39Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
17.39Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
17.39Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
17.39Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.24Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
17.24Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
17.24Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
17.24Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
17.24Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
17.24Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
17.24Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
17.24Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
17.14Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
17.14Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
16.67Single3OE6IT1t3OE6-CXCR4-IT1t
16.67Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
16.67Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
16.67Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
16.67Single6OS2TRV0266OS2-AT1-TRV026
16.67Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
16.67Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
16.67Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
16.67Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
16.67Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
16.67Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
16.67Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
16.67Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
16.67Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
16.67Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
16.67Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
16.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
16.67Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
16.67Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
16.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
16.67Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
16.67Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
16.67Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
16.67Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
16.28Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
16.22Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
16.13Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
16.13Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
16.13Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
16.13Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
16.13Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
16.13Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
16.13Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
16.13Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
16.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
16.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
16.00Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
16.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
16.00Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
16.00Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
16.00Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
15.79Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
15.79Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
15.79Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
15.79Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
15.79Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
15.79Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
15.79Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
15.79Single9B9Y7DY9B9Y-CB1-7DY
15.62Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
15.62Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
15.62Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
15.62Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
15.62Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
15.62Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
15.62Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
15.62Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
15.38Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
15.38Single8IEIA1LYA8IEI-GPR156-A1LYA
15.38Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
15.38Single8XQJJN2418XQJ-Apelin-JN241
15.38Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
15.38Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
15.15Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
15.15Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
15.15Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
15.15Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
15.15Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
15.15Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
15.15Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
15.00Single3ODUIT1t3ODU-CXCR4-IT1t
15.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
15.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
15.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
15.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
15.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
15.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
15.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
15.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
15.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
15.00Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
15.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
15.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
14.81Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
14.81Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
14.81Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
14.81Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8KIGSHU91198KIG-MC3-SHU9119-Ca
14.81Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
14.29Single6FFIMMPEP6FFI-mGlu5-MMPEP
14.29Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
14.29Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
14.29Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
14.29Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
14.29Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
14.29Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
14.29Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
14.29Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
14.29Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
14.29Single8K2WAMG4878K2W-CXCR3-AMG487
14.29Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
14.29Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.29Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
14.29Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
13.89Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
13.89Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
13.89Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
13.89Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.79Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.79Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.79Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single4QIMANTA XV4QIM-SMO-ANTA XV
13.64Single6FFHFenobam6FFH-mGlu5-Fenobam
13.64Single6IIVDaltroban6IIV-TP-Daltroban
13.64Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
13.64Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
13.64Single7YXAONO-54306087YXA-S1P5-ONO-5430608
13.64Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
13.64Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
13.64Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
13.64Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
13.64Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
13.64Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
13.64Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
13.51Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
13.51Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.33Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
13.33Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
13.33Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
13.33Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
13.04Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
13.04Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
13.04Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
13.04Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
13.04Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
13.04Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
13.04Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
13.04Consensusep_offOrthosteric Ligandep4_off
13.04Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
12.90Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
12.90Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
12.50Single5V56TC1145V56-SMO-TC114
12.50Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
12.50Single6OS1TRV0266OS1-AT1-TRV026
12.50Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
12.50Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
12.50Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
12.50Single7SK3CXCL127SK3-ACKR3-CXCL12
12.50Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
12.50Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
12.50Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
12.50Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9BJKNAM9BJK-μ-Naloxone-NAM
12.20Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
12.12Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
12.12Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
12.12Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
12.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
12.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
12.00Single4XESNeurotensin4XES-NTS1-Neurotensin
12.00Single5X33BIIL2605X33-BLT1-BIIL260
12.00Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
12.00Single6IIURamatroban6IIU-TP-Ramatroban
12.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
12.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
12.00Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
12.00Single8XQJJN2418XQJ-Apelin-JN241
12.00Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
12.00Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
12.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
12.00Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
12.00Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.00Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
12.00Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
11.90Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
11.76Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
11.76Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
11.76Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
11.76Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
11.76Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
11.54Single4BUONeurotensin4BUO-NTS1-Neurotensin
11.54Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
11.54Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
11.54Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
11.54Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
11.54Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
11.54Single8XVUCXCL28XVU-CXCR2-CXCL2
11.54Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
11.54Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.43Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
11.43Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
11.11Single3OE8IT1t3OE8-CXCR4-IT1t
11.11Single6KNMJN241-96KNM-Apelin-JN241-9
11.11Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
11.11Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
11.11Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
11.11Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
11.11Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
11.11Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
10.71Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.71Single8XWNCXCL88XWN-CXCR2-CXCL8
10.53Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
10.53Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
10.53Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
10.53Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
10.53Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
10.53Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
10.34Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
10.34Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
10.34Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.00Single5L7IVismodegib5L7I-SMO-Vismodegib
10.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.00Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
10.00Consensusgq_nucleotideOrthosteric Ligandgq_p2y
10.00Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.68Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
9.52Single5U09Taranabant5U09-CB1-Taranabant
9.52Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
9.52Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
9.52Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
9.52Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
9.52Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
9.52Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single9BA0A1AKN9BA0-CB1-A1AKN
9.52Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.38Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
9.09Single6ZINSR486926ZIN-NTS1-SR48692
9.09Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
9.09Single8IYXYL-3658IYX-GPR34-YL-365
9.09Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
8.82Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
8.70Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
8.70Single7F83PF-051904577F83-Ghrelin-PF-05190457
8.70Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
8.70Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
8.70Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
8.70Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
8.70Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.70Single9B9ZA1AKO9B9Z-CB1-A1AKO
8.70Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
8.70Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
8.70Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
8.33Single4JKVTaladegib4JKV-SMO-Taladegib
8.33Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
8.33Single6Z4SSR486926Z4S-NTS1-SR48692
8.33Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
8.33Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
8.33Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.33Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.33Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
8.11Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
8.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
8.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
8.00Single5V57TC1145V57-SMO-TC114
8.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
8.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
8.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
8.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
8.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
8.00Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
8.00Consensusneurotensin_onOrthosteric Ligandnts1_on
8.00Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.69Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
7.69Single6YVRNTS8-136YVR-NTS1-NTS8-13
7.69Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
7.69Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
7.69Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.69Single8XWACXCL18XWA-CXCR2-CXCL1
7.69Single8XWMCXCL68XWM-CXCR2-CXCL6
7.69Single8XWSCXCL58XWS-CXCR2-CXCL5
7.69Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
7.41Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
7.41Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
7.41Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
7.41Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
7.41Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
7.41Single8XWFCXCL38XWF-CXCR2-CXCL3
7.41Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
7.14Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
7.14Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
7.14Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
6.90Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
6.90Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
6.90Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
6.90Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
6.90Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
6.90Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
6.67Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
6.67Single7SHEPI; PE7SHE-GPR158-PI; PE
6.25Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
6.06Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
5.88Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
5.71Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
5.56Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.56Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
5.56Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
5.56Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.56Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
5.26Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
5.26Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
5.26Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
5.26Consensusp2y_offOrthosteric Ligandp2y1_off
5.00Single4XNWMRS25004XNW-P2Y1-MRS2500
5.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.00Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
5.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
5.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
4.76Single6LI0C176LI0-GPR52-C17
4.76Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
4.76Single7UL2SR486927UL2-NTS1-SR48692-Na
4.76Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
4.76Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
4.76Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
4.76Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusneurotensin_offOrthosteric Ligandnts1_off
4.76Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
4.55Single4BWBNeurotensin4BWB-NTS1-Neurotensin
4.55Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
4.55Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
4.55Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
4.55Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
4.55Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
4.55Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
4.55Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
4.55Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
4.55Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
4.35Single7VV6C48/807VV6-MRGPRX2-C48/80
4.35Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.17Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
4.17Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
4.17Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
4.17Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
4.17Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
4.00Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
3.85Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
3.85Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
3.70Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
3.70Single7SHEPI; PE7SHE-GPR158-PI; PE
3.70Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.45Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
3.33Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
3.23Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
7JVR 7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
8IRS 8IRS-D2-Rotigotine-Gi1/β1/γ2
Net Summary
Imin 2.385
Number of Linked Nodes 855
Number of Links 1206
Number of Hubs 253
Number of Links mediated by Hubs 888
Number of Communities 15
Number of Nodes involved in Communities 352
Number of Links involved in Communities 620
Path Summary
Number Of Nodes in MetaPath 126
Number Of Links MetaPath 125
Number of Shortest Paths 2382909
Length Of Smallest Path 3
Average Path Length 28.1018
Length of Longest Path 56
Minimum Path Strength 0.6475
Average Path Strength 5.71846
Maximum Path Strength 24.5425
Minimum Path Correlation 0.7
Average Path Correlation 0.983627
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.17391
Average % Of Corr. Nodes 43.4621
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 57.3081
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
d2_off_on_gpd2_on_gpd2_off
This network is also present in following consensuses:
IdComponents
dopamine_on_gpd2_on_gp
d1_on_gp
d3_on_gp
d4_on_gp
d5_on_gp



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download d2_on_gp.zip



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