Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:M37 4.332585
2R:R:K40 2.6225483
3R:R:Y51 5.4085107
4R:R:N62 4.8325409
5R:R:V65 3.43449
6R:R:V68 4.285447
7R:R:T75 2.1375406
8R:R:Y82 6.42333677
9R:R:D90 7.205409
10R:R:I97 5.044107
11R:R:W100 6.1437
12R:R:W110 5.3725438
13R:R:M112 3.16507
14R:R:C117 6.415439
15R:R:F124 4.0375437
16R:R:F129 3.754507
17R:R:F134 5.09408
18R:R:M138 5.69408
19R:R:T152 4.4454126
20R:R:R161 7.878577
21R:R:D179 8.35414
22R:R:C196 4.13539
23R:R:Y200 7.47857715
24R:R:P201 7.624515
25R:R:S204 6.2825413
26R:R:W208 8.8825414
27R:R:M212 3.55414
28R:R:Y232 7.2025459
29R:R:Y257 5.79558
30R:R:V260 2.75254147
31R:R:W265 7.41833609
32R:R:Y268 5.6225407
33R:R:H269 6.4408
34R:R:I283 2.155403
35R:R:H298 8.86405
36R:R:C308 4.7225409
37R:R:N311 5.638559
38R:R:P312 3.7625409
39R:R:Y315 5.924559
40R:R:Y322 8.422548
41L:L:Y7 14.1754130
42L:L:P10 4.645420
43L:L:K27 6.5425420
44L:L:I28 4.795400
45L:L:L29 5.406520
46L:L:Q37 6.456520
47L:L:V39 5.394520
48L:L:L42 2.8925400
49L:L:C50 4.9375420
50L:L:W57 10.115460
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:L29 L:L:P10 14.3746.57YesYes200
2L:L:C9 L:L:P10 30.28143.77NoYes000
3L:L:C34 L:L:C9 31.09377.28NoNo000
4L:L:C34 L:L:Y7 31.77266.72NoYes1300
5L:L:R12 L:L:Y7 36.56484.12NoYes000
6L:L:R12 R:R:I279 37.34436.26NoNo004
7R:R:I279 R:R:L280 35.98182.85NoNo041
8R:R:L280 R:R:Y282 35.19763.52NoNo011
9L:L:R47 R:R:Y282 27.928611.32NoNo001
10L:L:N45 L:L:R47 27.09763.62NoNo000
11L:L:L42 L:L:N45 26.26182.75YesNo000
12L:L:L42 L:L:V18 21.1494.47YesNo000
13L:L:I51 L:L:V18 20.28057.68NoNo000
14L:L:A40 L:L:I51 19.40491.62NoNo000
15L:L:A40 L:L:L26 18.5273.15NoNo000
16L:L:I38 L:L:L26 10.4274.28NoNo000
17L:L:P10 L:L:Q37 13.42824.74YesYes200
18R:R:D275 R:R:I279 65.67097NoNo044
19L:L:R8 R:R:D275 66.244514.29NoNo004
20L:L:R8 R:R:L297 67.33074.86NoNo005
21L:L:V3 R:R:L297 67.89265.96NoNo005
22L:L:V3 R:R:H298 16.326413.84NoYes005
23R:R:H298 R:R:L104 11.41496.43YesNo055
24R:R:L104 R:R:L44 10.48554.15NoNo052
25L:L:V3 R:R:Q301 75.94114.3NoNo006
26R:R:Q301 R:R:Y51 14.43253.38NoYes067
27R:R:Q301 R:R:Y268 83.61973.38NoYes067
28R:R:H269 R:R:Y268 86.58116.53YesYes087
29R:R:H269 R:R:W265 89.52854.23YesYes089
30R:R:H307 R:R:W265 75.545514.81NoYes099
31R:R:C308 R:R:H307 75.56654.42YesNo099
32R:R:C308 R:R:D90 1009.34YesYes099
33R:R:D90 R:R:N62 16.56056.73YesYes099
34R:R:N62 R:R:P312 13.93398.15YesYes099
35R:R:D90 R:R:N311 87.46145.39YesYes099
36R:R:N311 R:R:P312 20.45373.26YesYes099
37R:R:P312 R:R:V65 27.68991.77YesYes099
38R:R:V65 R:R:Y322 20.4423.79YesYes498
39R:R:L86 R:R:N311 52.47458.24NoYes099
40R:R:L86 R:R:M138 23.76632.83NoYes098
41R:R:N311 R:R:Y315 40.56095.81YesYes599
42R:R:M138 R:R:Y315 21.31058.38YesYes089
43R:R:V68 R:R:Y322 16.516112.62YesYes478
44R:R:E325 R:R:V68 11.08481.43NoYes047
45R:R:F134 R:R:L86 44.94573.65YesNo089
46R:R:M138 R:R:Y82 27.37857.18YesYes087
47R:R:R161 R:R:Y82 20.68553.09YesYes777
48R:R:L128 R:R:W265 18.84776.83NoYes089
49R:R:L128 R:R:V93 24.43114.47NoNo086
50R:R:F124 R:R:L128 38.10983.65YesNo078
51R:R:F124 R:R:W100 35.70337.02YesYes377
52L:L:L5 R:R:W100 33.44654.56NoYes307
53L:L:L5 R:R:C117 14.11883.17NoYes309
54R:R:C117 R:R:W110 11.562410.45YesYes398
55R:R:M112 R:R:W110 17.97694.65YesYes078
56L:L:L5 R:R:C196 18.53173.17NoYes309
57R:R:C196 R:R:W110 11.71463.92YesYes398
58R:R:M112 R:R:P111 10.84143.35YesNo073
59R:R:F134 R:R:V168 39.31315.24YesNo087
60R:R:F133 R:R:V168 38.58273.93NoNo067
61R:R:F129 R:R:F133 37.10795.36YesNo076
62R:R:F129 R:R:S125 33.33882.64YesNo074
63R:R:S125 R:R:S176 32.57096.52NoNo047
64R:R:L122 R:R:S176 30.07543NoNo1157
65R:R:L122 R:R:T180 29.45274.42NoNo054
66R:R:H121 R:R:T180 28.66149.58NoNo064
67R:R:D179 R:R:H121 27.86548.82YesNo046
68R:R:Y232 R:R:Y315 11.15984.96YesYes599
69R:R:K157 R:R:R161 18.18994.95NoYes067
70R:R:K157 R:R:T152 15.52584.5NoYes066
71R:R:I146 R:R:L235 15.57262.85NoNo088
72R:R:I146 R:R:T147 13.85434.56NoNo088
73R:R:T147 R:R:Y143 12.08917.49NoNo088
74R:R:Y257 R:R:Y315 19.39326.95YesYes589
75R:R:D179 R:R:Y200 25.38169.2YesYes145
76R:R:E207 R:R:S204 12.5411.44NoYes033
77R:R:C308 R:R:V93 24.48733.42YesNo096
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:H25 R:R:V28 8.3 0 No No 0 3 0 1
L:L:I28 R:R:V29 3.07 0 Yes No 0 3 0 1
L:L:K27 R:R:D30 4.15 2 Yes No 0 7 0 1
L:L:I28 R:R:T31 6.08 0 Yes No 0 4 0 1
L:L:N30 R:R:M33 5.61 0 No No 0 2 0 1
R:R:H298 R:R:L47 3.86 0 Yes No 5 6 1 2
R:R:Q301 R:R:Y51 3.38 0 No Yes 6 7 1 2
R:R:T120 R:R:W100 6.06 0 No Yes 5 7 2 1
R:R:F124 R:R:W100 7.02 3 Yes Yes 7 7 1 1
L:L:P2 R:R:W100 6.76 3 No Yes 0 7 0 1
L:L:L5 R:R:W100 4.56 3 No Yes 0 7 0 1
L:L:S4 R:R:S103 6.52 0 No No 0 6 0 1
R:R:H298 R:R:L104 6.43 0 Yes No 5 5 1 2
R:R:C117 R:R:W110 10.45 3 Yes Yes 9 8 1 2
R:R:C196 R:R:W110 3.92 3 Yes Yes 9 8 1 2
R:R:C117 R:R:L183 4.76 3 Yes No 9 4 1 2
R:R:C117 R:R:C196 7.28 3 Yes Yes 9 9 1 1
L:L:L5 R:R:C117 3.17 3 No Yes 0 9 0 1
R:R:D179 R:R:H121 8.82 1 Yes No 4 6 1 2
R:R:F124 R:R:L128 3.65 3 Yes No 7 8 1 2
L:L:P2 R:R:F124 2.89 3 No Yes 0 7 0 1
R:R:D179 R:R:S198 2.94 1 Yes No 4 4 1 1
R:R:D179 R:R:Y200 9.2 1 Yes Yes 4 5 1 2
L:L:K1 R:R:D179 12.44 1 No Yes 0 4 0 1
R:R:C196 R:R:L183 4.76 3 Yes No 9 4 1 2
L:L:L5 R:R:C196 3.17 3 No Yes 0 9 0 1
L:L:Y7 R:R:R197 31.9 13 Yes No 0 3 0 1
R:R:S198 R:R:Y200 10.17 1 No Yes 4 5 1 2
L:L:K1 R:R:S198 3.06 1 No No 0 4 0 1
R:R:E207 R:R:K206 6.75 0 No No 3 4 2 1
L:L:F13 R:R:K206 11.17 0 No No 0 4 0 1
R:R:Q301 R:R:Y268 3.38 0 No Yes 6 7 1 2
R:R:D275 R:R:I279 7 0 No No 4 4 1 1
L:L:R8 R:R:D275 14.29 0 No No 0 4 0 1
R:R:I279 R:R:L280 2.85 0 No No 4 1 1 2
L:L:R12 R:R:I279 6.26 0 No No 0 4 0 1
R:R:L280 R:R:Y282 3.52 0 No No 1 1 2 1
L:L:C11 R:R:H281 4.42 2 No No 0 2 0 1
L:L:C50 R:R:H281 2.95 2 Yes No 0 2 0 1
L:L:R47 R:R:Y282 11.32 0 No No 0 1 0 1
L:L:L29 R:R:F285 4.87 2 Yes No 0 2 0 1
R:R:F294 R:R:H298 11.31 9 No Yes 4 5 2 1
L:L:V3 R:R:L297 5.96 0 No No 0 5 0 1
L:L:R8 R:R:L297 4.86 0 No No 0 5 0 1
L:L:V3 R:R:H298 13.84 0 No Yes 0 5 0 1
L:L:V3 R:R:Q301 4.3 0 No No 0 6 0 1
R:R:R197 R:R:V186 2.62 0 No No 3 1 1 2
R:R:F124 R:R:T96 2.59 3 Yes No 7 7 1 2
L:L:F13 R:R:I205 2.51 0 No No 0 2 0 1
R:R:S103 R:R:W110 2.47 0 No Yes 6 8 1 2
R:R:I283 R:R:Y282 2.42 0 Yes No 3 1 2 1
R:R:C287 R:R:V32 1.71 0 No No 8 2 2 1
R:R:C196 R:R:E114 1.52 3 Yes No 9 1 1 2
L:L:L29 R:R:V32 1.49 2 Yes No 0 2 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
66.67Single7SK3CXCL127SK3-ACKR3-CXCL12
53.85Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
52.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
47.62Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
46.67Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
46.43Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
46.43Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
45.16Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
45.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
44.83Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
44.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
42.31Single3OE0CVX153OE0-CXCR4-CVX15
42.31Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
41.38Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
40.91Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
40.91Consensuscck_onOrthosteric Ligandccka_on cckb_on
40.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
40.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
40.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
40.00Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
39.29Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
39.13Single6OS2TRV0266OS2-AT1-TRV026
39.13Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
39.13Consensusdp_offOrthosteric Liganddp2_off
38.46Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
38.46Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
38.46Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
38.10Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
38.10Single6D27CAY104716D27-DP2-CAY10471
37.93Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
37.93Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
37.93Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
37.93Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
37.50Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
37.50Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
37.50Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
37.04Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
37.04Consensusangiotensin_onOrthosteric Ligandat1_on
37.04Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
37.04Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
36.84Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
36.67Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
36.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
36.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
36.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
36.00Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
36.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
36.00Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
36.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
35.71Single6JODAngiotensin II6JOD-AT2-Angiotensin II
35.71Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
35.71Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
35.71Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
35.71Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
35.71Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
35.71Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
35.48Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
35.29Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
35.29Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
35.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
35.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
34.78Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
34.78Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
34.78Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
34.78Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
34.78Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
34.62Single4XT1Fractalkine4XT1-US28-Fractalkine
34.62Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
34.62Single7F8XNN90567F8X-CCKA-NN9056
34.62Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
34.62Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
34.62Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
34.48Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
34.48Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.48Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
34.38Single5GLHEndothelin-15GLH-ETB-Endothelin-1
34.38Single6IGKEndothelin-36IGK-ETB-Endothelin-3
33.33Single4XT3Fractalkine4XT3-US28-Fractalkine
33.33Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
33.33Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
33.33Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
33.33Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
33.33Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
33.33Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
33.33Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
33.33Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
33.33Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
32.35Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
32.26Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
32.14Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
32.14Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
32.14Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
32.14Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
32.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
32.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
32.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
32.00Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
31.82Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
31.82Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
31.43Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
31.43Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
31.43Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
31.25Single6IGLIRL16206IGL-ETB-IRL1620
31.25Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
31.25Single8IY6Endothelin-18IY6-ETB-Endothelin-1
31.25Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
31.25Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
31.03Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
31.03Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
30.77Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
30.77Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.77Single7XN9L-054,5227XN9-SST2-L-054,522
30.77Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
30.77Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.77Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
30.43Single5N2SPSB365N2S-A1-PSB36
30.43Single6D26Fevipiprant6D26-DP2-Fevipiprant
30.43Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
30.30Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
30.00Single3OE9IT1t3OE9-CXCR4-IT1t
30.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
30.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
30.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
30.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
30.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
30.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
30.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
30.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
30.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
30.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
29.63Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
29.63Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
29.63Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
29.41Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
29.17Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
29.17Single6OS1TRV0266OS1-AT1-TRV026
29.17Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
29.17Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.17Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
29.17Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.03Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
29.03Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
28.57Single3ODUIT1t3ODU-CXCR4-IT1t
28.57Single3QAKUK-4320973QAK-A2A-UK-432097
28.57Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
28.57Single7F8ULintitript7F8U-CCKA-Lintitript
28.57Single7F8YDevazepide7F8Y-CCKA-Devazepide
28.57Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
28.57Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
28.57Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
28.57Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
28.57Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
28.57Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
28.57Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
28.57Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
28.57Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
28.12Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
28.12Consensusendothelin_onOrthosteric Ligandetb_on eta_on
28.12Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
28.00Single6MXTSalmeterol6MXT-β2-Salmeterol
28.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
28.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
28.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
28.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
28.00Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Single8JJLOlodaterol8JJL-β2-Olodaterol
28.00Consensuschemokine_offOrthosteric Ligandcxcr_off
28.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
28.00Consensuscxcr_offOrthosteric Ligandcxcr4_off
28.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
27.59Single5WF5UK-4320975WF5-A2A-UK-432097
27.59Single6PT2KGCHM076PT2-δ-KGCHM07
27.59Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
27.59Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.59Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
27.59Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
27.59Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.59Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
27.27Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
27.27Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
27.27Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
27.27Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
27.27Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
27.27Consensusgnrh_offOrthosteric Ligandgnrh1_off
27.27Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
27.27Consensushca_onOrthosteric Ligandhca2_on hca3_on
27.27Consensushcar_onOrthosteric Ligandhca_on
27.27Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
26.92Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
26.92Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
26.92Single7EZCUKA7EZC-A2A-UKA
26.92Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
26.92Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
26.92Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
26.92Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
26.92Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
26.83Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
26.67Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.67Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
26.67Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
26.67Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
26.67Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
26.67Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
26.09Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
26.09Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
26.09Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
26.09Single8K5DGSK2560738K5D-HCA2-GSK256073
26.09Consensuscck_offOrthosteric Ligandccka_off
26.09Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
26.09Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
26.09Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
26.09Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
26.09Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
25.93Single5WF6UK-4320975WF6-A2A-UK-432097
25.93Single6KNMJN241-96KNM-Apelin-JN241-9
25.93Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
25.93Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
25.93Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
25.93Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
25.81Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.81Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
25.81Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
25.81Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.81Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
25.71Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
25.00Single3OE6IT1t3OE6-CXCR4-IT1t
25.00Single3OE8IT1t3OE8-CXCR4-IT1t
25.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
25.00Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
25.00Single4XNWMRS25004XNW-P2Y1-MRS2500
25.00Single6FJ3PTH6FJ3-PTH1-PTH
25.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
25.00Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
25.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.00Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
25.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
25.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
25.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
25.00Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
25.00Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
25.00Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
25.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
25.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
25.00Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
25.00Consensussst_onOrthosteric Ligandsst2_on sst4_on
24.24Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
24.14Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
24.14Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
24.14Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
24.14Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
24.14Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
24.14Consensussst_offOrthosteric Ligandsst2_off
24.00Single5V56TC1145V56-SMO-TC114
24.00Single5V57TC1145V57-SMO-TC114
24.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
24.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
24.00Single7PX4PSB-21137PX4-A2A-PSB-2113
24.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
24.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
24.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
24.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
24.00Consensuschemerin_onOrthosteric Ligandcml1_on
24.00Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
24.00Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
24.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
24.00Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
24.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
23.81Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
23.81Single4O9RCyclopamine4O9R-SMO-Cyclopamine
23.81Single5L7IVismodegib5L7I-SMO-Vismodegib
23.81Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
23.53Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
23.33Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
23.33Single6W25SHU91196W25-MC4-SHU9119-Ca
23.33Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
23.33Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
23.33Single7XNACYN1548067XNA-SST2-CYN154806
23.33Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
23.33Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
23.33Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
23.33Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
23.08Single6A93Risperidone6A93-5-HT2A-Risperidone
23.08Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
23.08Single7K15MKD0467K15-BLT1-MKD046-Na
23.08Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
23.08Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.08Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
23.08Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
23.08Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.08Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
23.08Consensusblt_offOrthosteric Ligandblt1_off
23.08Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
23.08Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
23.08Consensusgs_steroidOrthosteric Ligandgs_bileacid
23.08Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
23.08Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
22.86Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
22.86Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
22.73Single4QINSAG1.54QIN-SMO-SAG1.5
22.73Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
22.73Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
22.73Single7BR3Elagolix7BR3-GnRH1-Elagolix
22.73Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
22.73Single7XRRLemborexant7XRR-OX2-Lemborexant
22.73Single8GNGIstradefylline8GNG-A2A-Istradefylline
22.73Single8IHKAcifran8IHK-HCA3-Acifran
22.73Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
22.73Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
22.73Consensusclass-f_offOrthosteric Ligandsmo_off
22.73Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
22.58Single7C61Ergotamine7C61-5-HT1B-Ergotamine
22.58Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.58Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
22.58Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
22.22Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
22.22Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
22.22Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
22.22Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
22.22Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
22.22Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
22.22Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
22.22Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
22.22Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
22.22Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
22.22Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
22.22Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
22.22Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.22Consensusorexin_onOrthosteric Ligandox2_on
22.22Consensussteroid_onOrthosteric Ligandbileacid_on
21.88Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
21.88Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
21.88Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
21.88Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
21.88Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
21.88Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
21.88Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.88Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
21.88Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
21.74Single5IU4ZM2413855IU4-A2A-ZM241385-Na
21.74Single5IUBQ274563445IUB-A2A-Q27456344-Na
21.74Single5K2CZM2413855K2C-A2A-ZM241385-Na
21.74Single5NM4ZM2413855NM4-A2A-ZM241385-Na
21.74Single6V9SGTPL114036V9S-OX1-GTPL11403
21.74Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
21.74Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
21.74Single6ZG9GSK10347026ZG9-M1-GSK1034702
21.74Single7AROLUF58337ARO-A2A-LUF5833-Na
21.74Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
21.74Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
21.74Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Single7T32ZM2413857T32-A2A-ZM241385
21.74Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
21.74Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
21.74Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
21.74Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
21.74Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
21.74Single8K5CAcipimox8K5C-HCA2-Acipimox
21.74Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
21.74Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
21.74Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
21.74Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
21.74Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
21.74Consensuss1p_offOrthosteric Ligands1p1_off
21.43Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
21.43Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
21.43Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
21.43Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
21.43Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
21.43Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
21.43Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
21.43Consensuslpl_offOrthosteric Ligands1p_off lpa_off
21.43Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.21Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
21.21Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
21.21Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
21.21Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
20.83Single4EIYZM2413854EIY-A2A-ZM241385-Na
20.83Single4YAYZD-71554YAY-AT1-ZD-7155
20.83Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
20.83Single5IU8Q274563475IU8-A2A-Q27456347-Na
20.83Single5OLGZM2413855OLG-A2A-ZM241385-Na
20.83Single5UENDU1725UEN-A1-DU172
20.83Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
20.83Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
20.83Single6LPJZM2413856LPJ-A2A-ZM241385-Na
20.83Single6LPKZM2413856LPK-A2A-ZM241385-Na
20.83Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
20.83Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
20.83Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
20.83Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
20.83Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
20.83Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
20.83Single7PYRPSB-21157PYR-A2A-PSB-2115
20.83Single8CU6LJ-45178CU6-A2A-LJ-4517
20.83Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
20.83Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
20.83Consensusa2_offOrthosteric Liganda2a_off
20.83Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
20.83Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
20.83Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
20.83Consensusgi_hcarOrthosteric Ligandgi_hca
20.83Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
20.83Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
20.83Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
20.83Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
20.69Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
20.69Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
20.69Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
20.69Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
20.69Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
20.69Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
20.69Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
20.69Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
20.59Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
20.59Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.59Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
20.59Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Single2Y00Dobutamine2Y00-β1-Dobutamine
20.00Single5C1MBU725C1M-μ-BU72
20.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
20.00Single5NM2ZM2413855NM2-A2A-ZM241385-Na
20.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
20.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
20.00Single6LPLZM2413856LPL-A2A-ZM241385-Na
20.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
20.00Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
20.00Single6S0QZM2413856S0Q-A2A-ZM241385
20.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
20.00Single6WQAZM2413856WQA-A2A-ZM241385-Na
20.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
20.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
20.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
20.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
20.00Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
20.00Single7RM5ZM2413857RM5-A2A-ZM241385-Na
20.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
20.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
20.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
20.00Single8FYNZM2413858FYN-A2A-ZM241385-Na
20.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
20.00Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8QOTNanobody E8QOT-μ-Nanobody E
20.00Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
20.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
20.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
19.44Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
19.44Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
19.35Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
19.35Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
19.35Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
19.35Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.35Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
19.23Single3P0GBI1671073P0G-β2-BI167107
19.23Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
19.23Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
19.23Single4RWADIPP-NH24RWA-δ-DIPP-NH2
19.23Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
19.23Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
19.23Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
19.23Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
19.23Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
19.23Single7B6WCyclazosin7B6W-α1b-Cyclazosin
19.23Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
19.23Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
19.23Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
19.23Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
19.23Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
19.23Single8E0GBU728E0G-μ-BU72
19.23Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
19.23Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
19.23Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
19.05Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
19.05Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
19.05Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
18.92Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
18.92Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
18.75Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
18.75Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
18.75Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
18.75Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
18.75Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
18.75Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
18.75Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
18.75Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.52Single4XEENeurotensin4XEE-NTS1-Neurotensin
18.52Single4XESNeurotensin4XES-NTS1-Neurotensin
18.52Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
18.52Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
18.52Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
18.52Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
18.52Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
18.52Single6YVRNTS8-136YVR-NTS1-NTS8-13
18.52Single7DFPSpiperone7DFP-D2-Spiperone
18.52Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
18.52Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
18.52Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
18.52Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
18.52Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
18.52Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
18.52Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.52Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
18.52Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
18.52Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
18.52Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single8JJ8Formoterol8JJ8-β2-Formoterol
18.52Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
18.52Single8JWZAB9288JWZ-A2A-AB928-Na
18.52Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
18.52Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
18.52Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
18.52Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
18.52Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
18.52Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.52Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
18.52Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
18.52Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
18.52Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
18.52Consensusnts_onOrthosteric Ligandnts1_on
18.52Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.52Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
18.42Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
18.18Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
18.18Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
18.18Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
18.18Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
18.18Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
18.18Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
18.18Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
18.18Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
18.18Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8GH1Epinephrine8GH1-β2-Epinephrine
18.18Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
18.18Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
18.18Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
18.18Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
18.18Single8K5BNiacin8K5B-HCA2-Niacin
18.18Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
18.18Consensusclass-t_onOrthosteric Ligandtaste2_on
18.18Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
18.18Consensusgo_proteinOrthosteric Ligandgo_chemokine
18.18Consensusgs_class-tOrthosteric Ligandgs_taste
18.18Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
18.18Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
17.95Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
17.95Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
17.95Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
17.86Single4BUONeurotensin4BUO-NTS1-Neurotensin
17.86Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
17.86Single6H7LDobutamine6H7L-β1-Dobutamine
17.86Single6IBLArformoterol6IBL-β1-Arformoterol
17.86Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
17.86Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
17.86Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
17.86Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
17.86Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
17.86Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
17.86Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
17.65Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
17.65Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
17.50Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
17.50Consensuspth_onOrthosteric Ligandpth1_on pth2_on
17.39Single3PWHZM2413853PWH-A2A-ZM241385
17.39Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
17.39Single4S0VSuvorexant4S0V-OX2-Suvorexant
17.39Single5DHHSB-6121115DHH-NOP-SB-612111
17.39Single5K2DZM2413855K2D-A2A-ZM241385
17.39Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
17.39Single5WS3EMPA5WS3-OX2-EMPA
17.39Single5ZKQABT-4915ZKQ-PAF-ABT-491
17.39Single6JZHZM2413856JZH-A2A-ZM241385-Na
17.39Single6PS7ZM2413856PS7-A2A-ZM241385-Na
17.39Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
17.39Single6TPJSuvorexant6TPJ-OX2-Suvorexant
17.39Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
17.39Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
17.39Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
17.39Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
17.39Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Single8IWESpermidine8IWE-TAAR9-Spermidine
17.39Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
17.39Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
17.39Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
17.39Consensusorexin_offOrthosteric Ligandox2_off ox1_off
17.39Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
17.24Single4UG2CGS216804UG2-A2A-CGS21680
17.24Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
17.24Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
17.24Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
17.24Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single8X5YAstemizole8X5Y-H1-Astemizole
17.24Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
17.24Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
17.24Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
17.24Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Consensuslpl_onOrthosteric Ligands1p_on lpa_on
17.24Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
17.14Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
17.14Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
17.14Consensusgo_class-b1Orthosteric Ligandgo_crf
17.14Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
16.67Single3REYPubChem 56973REY-A2A-PubChem 5697
16.67Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
16.67Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
16.67Single4ZJCSB-6740424ZJC-OX1-SB-674042
16.67Single5IU7Q274563465IU7-A2A-Q27456346-Na
16.67Single5JTBZM2413855JTB-A2A-ZM241385
16.67Single5K2BZM2413855K2B-A2A-ZM241385-Na
16.67Single5NLXZM2413855NLX-A2A-ZM241385-Na
16.67Single6AQFZM2413856AQF-A2A-ZM241385
16.67Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
16.67Single6DS0Ly2660976DS0-5-HT2B-Ly266097
16.67Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
16.67Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
16.67Single6MH8ZM2413856MH8-A2A-ZM241385
16.67Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
16.67Single6TP3Nemorexant6TP3-OX1-Nemorexant
16.67Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
16.67Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
16.67Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
16.67Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
16.67Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
16.67Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
16.67Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
16.67Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
16.67Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
16.67Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
16.67Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
16.67Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GGTEpinephrine8GGT-β2-Epinephrine
16.67Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
16.67Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
16.67Single8K2WAMG4878K2W-CXCR3-AMG487
16.67Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
16.67Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
16.67Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
16.67Consensusgi_class-fOrthosteric Ligandgi_frizzled
16.67Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
16.67Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
16.67Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.67Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
16.67Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
16.67Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
16.28Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
16.22Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
16.13Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
16.13Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
16.13Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
16.13Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
16.13Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
16.00Single2Y01Dobutamine2Y01-β1-Dobutamine
16.00Single2Y02Carmoterol2Y02-β1-Carmoterol
16.00Single3EMLZM2413853EML-A2A-ZM241385
16.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
16.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
16.00Single5K2AZM2413855K2A-A2A-ZM241385-Na
16.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
16.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
16.00Single5T04Neurotensin5T04-NTS1-Neurotensin
16.00Single5VRAZM2413855VRA-A2A-ZM241385-Na
16.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
16.00Single6GPSMK08126GPS-CCR2-MK0812
16.00Single6PS1Timolol6PS1-β2-Timolol
16.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
16.00Single6S0LZM2413856S0L-A2A-ZM241385
16.00Single6TOTLemborexant6TOT-OX1-Lemborexant
16.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
16.00Single7BU7BI1671077BU7-β1-BI167107
16.00Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
16.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
16.00Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
16.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
16.00Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
16.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
16.00Single7UL4Alvimopan7UL4-μ-Alvimopan
16.00Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
16.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
16.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
16.00Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
16.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
16.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
16.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
16.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
16.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
16.00Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
16.00Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
16.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
16.00Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
16.00Consensusadenosine_onOrthosteric Liganda1_on a2_on
16.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
16.00Consensusblt_onOrthosteric Ligandblt1_on
16.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
16.00Consensushcar_offOrthosteric Ligandsuccinate_off
16.00Consensusleuko_onOrthosteric Ligandblt_on
16.00Consensusnucleotide_onOrthosteric Ligandadenosine_on
16.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
16.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
15.79Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
15.79Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
15.79Consensusglp_onOrthosteric Ligandglp1_on glp2_on
15.62Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.62Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
15.62Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
15.56Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
15.38Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
15.38Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
15.38Single5WIUNemonapride5WIU-D4-Nemonapride
15.38Single5WIVNemonapride5WIV-D4-Nemonapride-Na
15.38Single5WQCEMPA5WQC-OX2-EMPA
15.38Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
15.38Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
15.38Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
15.38Single6E67BI1671076E67-β2-BI167107-Gs (fused)
15.38Single6GPXMK08126GPX-CCR2-MK0812
15.38Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
15.38Single6LUQHaloperidol6LUQ-D2-Haloperidol
15.38Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
15.38Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
15.38Single6TP6Filorexant6TP6-OX1-Filorexant
15.38Single7C4SS1P7C4S-S1P3-S1P
15.38Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
15.38Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
15.38Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
15.38Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
15.38Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
15.38Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
15.38Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
15.38Single7XKAEpinephrine7XKA-β2-Epinephrine
15.38Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.38Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.38Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
15.38Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
15.38Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
15.38Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
15.38Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
15.38Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
15.38Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
15.38Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
15.38Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
15.38Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
15.38Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
15.38Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
15.38Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
15.38Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
15.38Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
15.38Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
15.38Consensusep_offOrthosteric Ligandep4_off
15.38Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
15.38Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
15.38Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
15.15Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
15.15Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
15.00Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
15.00Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
14.81Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
14.81Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
14.81Single4BV0Neurotensin4BV0-NTS1-Neurotensin
14.81Single4DJHJDTic4DJH-κ-JDTic
14.81Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
14.81Single5XR8AM8415XR8-CB1-AM841
14.81Single5XRAAM115425XRA-CB1-AM11542
14.81Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
14.81Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
14.81Single6TQ7SB-3348676TQ7-OX1-SB-334867
14.81Single6WGTLSD6WGT-5-HT2A-LSD
14.81Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
14.81Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
14.81Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
14.81Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
14.81Single7W41PD1762527W41-BB2-PD176252
14.81Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
14.81Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
14.81Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
14.81Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
14.81Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
14.81Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
14.81Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
14.81Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
14.81Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
14.81Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
14.81Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
14.81Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
14.81Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
14.81Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
14.81Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
14.81Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
14.81Consensusa2_onOrthosteric Liganda2a_on a2b_on
14.81Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
14.81Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
14.81Consensusbombesin_offOrthosteric Ligandbb2_off
14.81Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
14.81Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
14.81Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
14.81Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
14.81Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
14.81Consensuslpa_offOrthosteric Ligandlpa1_off
14.81Consensuslpa_onOrthosteric Ligandlpa1_on
14.81Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
14.81Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
14.81Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
14.71Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
14.71Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
14.63Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
14.29Single3RFMCaffeine3RFM-A2A-Caffeine
14.29Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
14.29Single4AMIBucindolol4AMI-β1-Bucindolol
14.29Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
14.29Single4LDEBI1671074LDE-β2-BI167107
14.29Single4PY02MeSATP4PY0-P2Y12-2MeSATP
14.29Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
14.29Single5X33BIIL2605X33-BLT1-BIIL260
14.29Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
14.29Single6CM4Risperidone6CM4-D2-Risperidone
14.29Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
14.29Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
14.29Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
14.29Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.29Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
14.29Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single6ZG4HTL00099366ZG4-M1-HTL0009936
14.29Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
14.29Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
14.29Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
14.29Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
14.29Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
14.29Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
14.29Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
14.29Single7YITNalfurafine7YIT-κ-Nalfurafine
14.29Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
14.29Single8A2OTheophylline8A2O-A2A-Theophylline-Na
14.29Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
14.29Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
14.29Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
14.29Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
14.29Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
14.29Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
14.29Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
14.29Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
14.29Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
14.29Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
14.29Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
14.29Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
14.29Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
13.95Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
13.89Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
13.89Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.89Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
13.79Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
13.79Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
13.79Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
13.79Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
13.79Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
13.79Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
13.79Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
13.79Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
13.79Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
13.79Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
13.79Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
13.79Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
13.79Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.79Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
13.79Consensusendothelin_offOrthosteric Ligandetb_off
13.79Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
13.79Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
13.79Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.79Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
13.79Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
13.64Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
13.64Single6LI0GTPL98046LI0-GPR52-GTPL9804
13.64Single6ME5Agomelatine6ME5-MT1-Agomelatine
13.64Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
13.64Single7WC5Psilocin7WC5-5-HT2A-Psilocin
13.64Single8GGREpinephrine8GGR-β2-Epinephrine
13.64Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
13.51Single6LMLGlucagon6LML-Glucagon-Glucagon
13.51Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
13.51Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
13.51Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
13.51Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.33Single3NY9PubChem 9131033NY9-β2-PubChem 913103
13.33Single5EE7MK08935EE7-Glucagon-MK0893
13.33Single6PT3DPI-2876PT3-δ-DPI-287
13.33Single7SK9CCX6627SK9-ACKR3-CCX662
13.33Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
13.16Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
13.16Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
13.16Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
13.16Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
13.04Single6HLLCP999946HLL-NK1-CP99994
13.04Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
13.04Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
13.04Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
13.04Single7UL2SR486927UL2-NTS1-SR48692-Na
13.04Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
13.04Single8GGSEpinephrine8GGS-β2-Epinephrine
13.04Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.04Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.04Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
13.04Consensusgo_class-b2Orthosteric Ligandgo_adhesion
13.04Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
13.04Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
13.04Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
13.04Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
12.90Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
12.90Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
12.90Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
12.90Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
12.90Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
12.82Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
12.50Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
12.50Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
12.50Single4BWBNeurotensin4BWB-NTS1-Neurotensin
12.50Single5U09Taranabant5U09-CB1-Taranabant
12.50Single6AKXA4R6AKX-CCR5-A4R
12.50Single6AKYMaraviroc6AKY-CCR5-Maraviroc
12.50Single6HLOAprepitant6HLO-NK1-Aprepitant
12.50Single6KUXRS-799486KUX-α2a-RS-79948
12.50Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
12.50Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
12.50Single6TODEMPA6TOD-OX1-EMPA-Na
12.50Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
12.50Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
12.50Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.50Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
12.50Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
12.50Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
12.50Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
12.50Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
12.50Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
12.50Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
12.50Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
12.50Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
12.50Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
12.50Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
12.50Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
12.50Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
12.50Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8GGVEpinephrine8GGV-β2-Epinephrine
12.50Single8GGWEpinephrine8GGW-β2-Epinephrine
12.50Single8GGXEpinephrine8GGX-β2-Epinephrine
12.50Single8GH0Epinephrine8GH0-β2-Epinephrine
12.50Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
12.50Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
12.50Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
12.50Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
12.50Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
12.50Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
12.50Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
12.12Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
12.00Single2YDOAdenosine2YDO-A2A-Adenosine
12.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
12.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
12.00Single5UVIZM2413855UVI-A2A-ZM241385
12.00Single6IQLL7458706IQL-D4-L745870
12.00Single6PS4ICI 118-5516PS4-β2-ICI 118-551
12.00Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
12.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
12.00Single6TPGEMPA6TPG-OX2-EMPA
12.00Single6VI4JDTic6VI4-κ-JDTic
12.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
12.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
12.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
12.00Single7VV6C48/807VV6-MRGPRX2-C48/80
12.00Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
12.00Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
12.00Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
12.00Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
12.00Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
12.00Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
12.00Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
12.00Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
12.00Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.00Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.00Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.00Single8GGIEpinephrine8GGI-β2-Epinephrine
12.00Single8GGKEpinephrine8GGK-β2-Epinephrine
12.00Single8GGMEpinephrine8GGM-β2-Epinephrine
12.00Single8GGPEpinephrine8GGP-β2-Epinephrine
12.00Single8GGQEpinephrine8GGQ-β2-Epinephrine
12.00Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
12.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
12.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
12.00Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.00Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.00Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.00Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
12.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
12.00Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
12.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
11.76Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
11.76Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
11.76Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
11.54Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
11.54Single2Y04Salbutamol2Y04-β1-Salbutamol
11.54Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
11.54Single3NY8ICI 118-5513NY8-β2-ICI 118-551
11.54Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
11.54Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
11.54Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
11.54Single4EJ4Naltrindole4EJ4-δ-Naltrindole
11.54Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
11.54Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
11.54Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
11.54Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
11.54Single5TGZAM65385TGZ-CB1-AM6538
11.54Single6DRXLisuride6DRX-5-HT2B-Lisuride
11.54Single6H7MSalbutamol6H7M-β1-Salbutamol
11.54Single6IIVDaltroban6IIV-TP-Daltroban
11.54Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
11.54Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
11.54Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
11.54Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
11.54Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
11.54Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
11.54Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
11.54Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
11.54Single7F83PF-051904577F83-Ghrelin-PF-05190457
11.54Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
11.54Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
11.54Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
11.54Single7WC7Lisuride7WC7-5-HT2A-Lisuride
11.54Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
11.54Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
11.54Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
11.54Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
11.54Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.54Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.54Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.54Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.54Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.54Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.54Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.54Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.54Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.54Single8GGJEpinephrine8GGJ-β2-Epinephrine
11.54Single8GGNEpinephrine8GGN-β2-Epinephrine
11.54Single8GGOEpinephrine8GGO-β2-Epinephrine
11.54Single8GGUEpinephrine8GGU-β2-Epinephrine
11.54Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
11.54Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
11.54Single8JJOAlprenolol8JJO-β2-Alprenolol
11.54Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
11.54Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.54Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.54Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
11.54Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
11.54Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
11.54Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
11.54Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
11.54Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
11.54Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
11.54Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
11.54Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
11.54Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
11.54Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
11.54Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
11.43Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
11.36Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
11.11Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
11.11Single2Y03Isoprenaline2Y03-β1-Isoprenaline
11.11Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
11.11Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
11.11Single5TVNLSD5TVN-5-HT2B-LSD
11.11Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
11.11Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
11.11Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
11.11Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
11.11Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
11.11Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
11.11Single6PS6Timolol6PS6-β2-Timolol
11.11Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
11.11Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
11.11Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
11.11Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
11.11Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
11.11Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
11.11Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
11.11Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
11.11Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
11.11Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
11.11Single7SINNPS-21437SIN-CaS-NPS-2143
11.11Single7SINNPS-21437SIN-CaS-NPS-2143
11.11Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
11.11Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
11.11Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
11.11Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
11.11Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
11.11Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
11.11Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
11.11Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
11.11Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
11.11Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
11.11Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
11.11Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
11.11Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
11.11Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
11.11Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
11.11Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
11.11Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
10.87Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
10.81Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
10.81Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
10.81Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
10.71Single2YDVNECA2YDV-A2A-NECA
10.71Single4UHRCGS216804UHR-A2A-CGS21680
10.71Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
10.71Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
10.71Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
10.71Single5G53NECA5G53-A2A-NECA-Gs
10.71Single5TZR-5TZR-FFA1 (GPR40)-MK8666
10.71Single5X93K-87945X93-ETB-K-8794
10.71Single6H7JIsoprenaline6H7J-β1-Isoprenaline
10.71Single6J20Aprepitant6J20-NK1-Aprepitant
10.71Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
10.71Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
10.71Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
10.71Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
10.71Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
10.71Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
10.71Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
10.71Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
10.71Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
10.71Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
10.71Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
10.71Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
10.71Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
10.71Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
10.71Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
10.71Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
10.71Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
10.71Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
10.71Consensus5ht5_offOrthosteric Ligand5ht5a_off
10.71Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
10.71Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
10.71Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
10.71Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
10.71Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
10.71Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
10.71Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
10.71Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
10.71Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
10.53Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
10.53Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
10.34Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
10.34Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
10.34Single4N4WSANT-14N4W-SMO-SANT-1
10.34Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
10.34Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
10.34Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
10.34Single6IIURamatroban6IIU-TP-Ramatroban
10.34Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
10.34Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
10.34Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
10.34Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
10.34Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
10.34Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
10.34Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
10.34Single8WU1KCA8WU1-CB1-KCA-Arrestin1
10.34Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
10.34Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
10.34Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
10.34Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
10.34Consensusnts_offOrthosteric Ligandnts1_off
10.34Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
10.34Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
10.34Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
10.26Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
10.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
10.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
10.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
10.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
10.00Single6K1QIRL25006K1Q-ETB-IRL2500
10.00Single6W25Ca6W25-MC4-SHU9119-Ca
10.00Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
10.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
10.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
10.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
10.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
10.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
10.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
10.00Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
10.00Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
10.00Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.76Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
9.68Single5ZTYAM102575ZTY-CB2-AM10257
9.68Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
9.68Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
9.68Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.68Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
9.68Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.68Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.68Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
9.68Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
9.68Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
9.68Consensusclass-d_offOrthosteric Ligandste2_off
9.52Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
9.52Single7WC4Serotonin7WC4-5-HT2A-Serotonin
9.52Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
9.52Single8PWNTheophylline8PWN-A2A-Theophylline
9.52Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
9.38Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
9.38Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
9.38Single7QA8Peptide7QA8-STE2-Peptide
9.38Single7QA8Peptide7QA8-STE2-Peptide
9.38Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
9.38Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
9.38Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
9.38Consensusclass-d_offOrthosteric Ligandste2_off
9.30Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
9.09Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.09Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
9.09Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
9.09Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
9.09Consensussensory_onOrthosteric Ligandopsin_on
8.70Single3UZAGTPL92363UZA-A2A-GTPL9236
8.70Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
8.70Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
8.70Single6ME9Ramelteon6ME9-MT2-Ramelteon
8.70Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
8.70Single8GGZEpinephrine8GGZ-β2-Epinephrine
8.70Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
8.70Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
8.70Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
8.70Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
8.70Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
8.70Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
8.70Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
8.57Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
8.57Consensusclass-d_onOrthosteric Ligandste2_on
8.57Consensusgi_class-dOrthosteric Ligandgi_ste
8.57Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
8.33Single3PBLEticlopride3PBL-D3-Eticlopride
8.33Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
8.33Single6TP4ACT-4622066TP4-OX1-ACT-462206
8.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
8.33Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
8.33Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
8.33Single7SRQLSD7SRQ-5-HT2B-LSD
8.33Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
8.33Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
8.33Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
8.33Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
8.33Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
8.33Single8GGYEpinephrine8GGY-β2-Epinephrine
8.33Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
8.33Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
8.33Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
8.33Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
8.11Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
8.11Consensusclass-d_onOrthosteric Ligandste2_on
8.11Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
8.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
8.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
8.00Single6B73PubChem 1319551386B73-κ-PubChem 131955138
8.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
8.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
8.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
8.00Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
8.00Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
8.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
8.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
8.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
8.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
8.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
8.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
8.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
8.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
8.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
8.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
8.00Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
8.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
8.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
8.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
8.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
8.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
8.00Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
8.00Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
8.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
8.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
8.00Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
8.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
8.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
8.00Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
8.00Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Consensusgt_class-aOrthosteric Ligandgt_opsin
8.00Consensusgt_opsinOrthosteric Ligandgt_sensory
8.00Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
8.00Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
8.00Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
8.00Consensusmglu_onOther Ligandmglu2_on mglu4_on
7.89Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
7.89Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
7.89Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
7.89Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
7.89Consensusgi_class-dOrthosteric Ligandgi_ste
7.89Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
7.89Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
7.69Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
7.69Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
7.69Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
7.69Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
7.69Single6A94Zotepine6A94-5-HT2A-Zotepine
7.69Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
7.69Single6TPKRetosiban6TPK-OT-Retosiban
7.69Single6TPNHTL66416TPN-OX2-HTL6641
7.69Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
7.69Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
7.69Single6ZINSR486926ZIN-NTS1-SR48692
7.69Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
7.69Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
7.69Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
7.69Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
7.69Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
7.69Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
7.69Single7VODCariprazine7VOD-5-HT2A-Cariprazine
7.69Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
7.69Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
7.69Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
7.69Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
7.69Single8GGLEpinephrine8GGL-β2-Epinephrine
7.69Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
7.69Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
7.69Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
7.69Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
7.69Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
7.69Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.69Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Consensus5ht5_onOrthosteric Ligand5ht5a_on
7.69Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
7.69Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
7.69Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
7.69Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
7.69Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
7.69Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
7.69Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
7.69Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
7.69Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
7.69Consensusvasopressin-ot_offOrthosteric Ligandot_off
7.50Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
7.50Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
7.50Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
7.41Single4DAJTiotropium4DAJ-M3-Tiotropium
7.41Single4MQSIperoxo4MQS-M2-Iperoxo
7.41Single4U14Tiotropium4U14-M3-Tiotropium
7.41Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
7.41Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
7.41Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
7.41Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
7.41Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
7.41Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
7.41Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.41Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
7.41Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
7.41Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
7.41Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
7.41Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
7.41Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
7.41Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
7.41Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
7.41Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
7.41Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
7.41Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
7.41Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
7.41Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
7.41Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.41Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
7.41Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Single8X63Mepyramine8X63-H1-Mepyramine
7.41Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
7.41Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
7.41Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
7.41Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
7.41Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.41Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
7.41Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
7.41Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
7.41Consensushistamine_onOrthosteric Ligandh1_on h4_on
7.41Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
7.41Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
7.41Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
7.41Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
7.41Consensustachykinin_offOrthosteric Ligandnk1_off
7.41Consensustar_onOrthosteric Ligandta1_on
7.32Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
7.14Single4NTJAZD12834NTJ-P2Y12-AZD1283
7.14Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
7.14Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
7.14Single5CGCHTL142425CGC-mGlu5-HTL14242
7.14Single5XPRBosentan5XPR-ETB-Bosentan
7.14Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
7.14Single6Z4SSR486926Z4S-NTS1-SR48692
7.14Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
7.14Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
7.14Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
7.14Single7WC6LSD7WC6-5-HT2A-LSD
7.14Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single8EA0Iperoxo8EA0-M3-Iperoxo
7.14Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
7.14Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
7.14Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
7.14Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
7.14Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.14Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
7.14Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
7.14Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
7.14Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
7.14Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
7.14Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
7.14Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
7.14Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
7.14Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.98Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
6.90Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
6.90Single4U15Tiotropium4U15-M3-Tiotropium
6.90Single5V54Methiothepin5V54-5-HT1B-Methiothepin
6.90Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
6.90Single6E59L-7607356E59-NK1-L-760735
6.90Single6J21Aprepitant6J21-NK1-Aprepitant
6.90Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
6.90Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
6.90Single6OL9Tiotropium6OL9-M5-Tiotropium
6.90Single7EPENAM5637EPE-mGlu-NAM563
6.90Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
6.90Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
6.90Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
6.90Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
6.90Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
6.90Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
6.90Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
6.90Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.90Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
6.90Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
6.90Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
6.90Consensus5ht1_offOrthosteric Ligand5ht1b_off
6.90Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
6.90Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
6.90Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
6.90Consensushistamine_offOrthosteric Ligandh1_off
6.90Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
6.90Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
6.90Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
6.67Single5CXVTiotropium5CXV-M1-Tiotropium
6.67Single6HLPNetupitant6HLP-NK1-Netupitant
6.67Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.67Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
6.67Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
6.67Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
6.67Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
6.67Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
6.67Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
6.67Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
6.67Consensusclass-b2_onOrthosteric Ligandadgrg_on
6.67Consensusgi_class-fOther Ligandgi_frizzled
6.67Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.67Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
6.45Single5CGDHTL142425CGD-mGlu5-HTL14242
6.45Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
6.45Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
6.45Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.45Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
6.45Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.38Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
6.25Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
6.25Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Consensusgs_class-b2Orthosteric Ligandgs_adgr
6.25Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
6.00Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
5.56Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.56Single6D35Cholesterol6D35-SMO-Cholesterol
5.56Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.56Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.56Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
5.56Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
5.56Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.56Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.56Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.56Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
5.56Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
5.56Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
5.56Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
5.56Single7DTTCa7DTT-CaS-Ca-Ca
5.56Single7DTTCa7DTT-CaS-Ca-Ca
5.56Single7DTUTryptophan7DTU-CaS-Tryptophan
5.56Single7DTUTryptophan7DTU-CaS-Tryptophan
5.56Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.56Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.56Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.56Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.56Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.56Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.56Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
5.56Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
5.56Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
5.56Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.56Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.56Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.56Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.56Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.56Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.56Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Single7FIIhCG7FII-LH-hCG-6fuf
5.56Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
5.56Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
5.56Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.56Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.56Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.56Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.56Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.56Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.56Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
5.56Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
5.56Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.56Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.56Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.56Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.56Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
5.56Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.56Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.56Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.56Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.56Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.56Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.56Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
5.56Single7XW7K1-707XW7-TSH-K1-70
5.56Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.56Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.56Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.56Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.56Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.56Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.56Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.56Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.56Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.56Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.56Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.56Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.56Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
5.56Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.56Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.56Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.56Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.56Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
5.56Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
5.56Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.56Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.56Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
5.56Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
5.56Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.56Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.56Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.56Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
5.56Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
5.56Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
5.56Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
5.56Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.56Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.56Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.56Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.56Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.56Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.56Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.56Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.56Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.56Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.56Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.56Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.56Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
5.56Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
5.56Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
5.56Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
5.56Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
5.56Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.56Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
5.56Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
5.56Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
5.56Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
5.56Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Consensusgphr_onOrthosteric Ligandlh_on tsh_on
5.56Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
5.56Consensusgs_proteinOrthosteric Ligandgs_gphr
5.56Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
5.56Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
5.56Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
5.56Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.56Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.56Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
5.56Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
5.56Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
5.56Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
5.56Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
5.56Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
5.56Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
5.56Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
5.56Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
5.56Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
5.56Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
5.26Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.26Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.26Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.26Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.26Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.26Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.00Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
5.00Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
5.00Single8HS2Fab0468HS2-GPR20-Fab046
4.88Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.88Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
4.76Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.76Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
4.76Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
4.76Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.76Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.76Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
4.65Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
4.65Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.55Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
4.55Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
4.55Single5L7DCholesterol5L7D-SMO-Cholesterol
4.55Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
4.55Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
4.55Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
4.55Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.55Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.55Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
4.55Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.35Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
4.35Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
4.35Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
4.35Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
4.35Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
4.17Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
4.17Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
4.17Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
4.17Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
4.17Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
4.17Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
4.17Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
4.17Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
4.17Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
4.17Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
4.17Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
4.17Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
4.17Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
4.17Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
4.17Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
4.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
4.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
4.00Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
4.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
4.00Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
4.00Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
4.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
4.00Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
4.00Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
4.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
4.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
4.00Single8J6QCompound 9n8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
4.00Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
4.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
4.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
4.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
4.00Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
4.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
4.00Consensushca2_on_alloOther Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
4.00Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
3.85Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
3.85Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
3.85Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
3.85Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
3.85Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
3.85Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
3.85Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
3.85Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.85Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
3.85Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
3.85Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
3.85Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
3.85Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
3.85Single8G94CD698G94-S1P1-CD69-Gi1/&β;1/&γ;2
3.85Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
3.85Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
3.85Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2
3.85Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.85Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
3.85Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
3.85Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
3.70Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
3.70Single3RZECidoxepin3RZE-H1-Cidoxepin
3.70Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
3.70Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
3.70Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
3.70Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
3.70Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
3.70Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
3.70Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
3.70Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
3.70Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
3.70Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
3.70Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.70Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
3.70Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
3.70Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
3.70Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
3.70Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
3.70Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
3.70Consensussensory_offOrthosteric Ligandopsin_off
3.57Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
3.57Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
3.57Single5DSGTiotropium5DSG-M4-Tiotropium
3.57Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
3.57Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
3.57Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
3.57Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.57Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
3.57Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
3.57Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
3.57Single8X64Desloratadine8X64-H1-Desloratadine
3.57Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
3.57Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
3.45Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
3.45Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
3.33Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
3.33Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
3.33Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
3.33Single7P2L4YI7P2L-mGlu5-4YI
3.33Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.12Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
3.03Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
2.94Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
2.70Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645

PDB Summary
PDB 7SK5
Class A
SubFamily Protein
Type Chemokine
SubType ACKR3
Species Homo sapiens
Ligand CXCL12
Other Ligand(s) -
Protein Partners -
PDB Resolution 4
Date 2022-07-27
D.O.I. 10.1126/sciadv.abn8063
Net Summary
Imin 2.83
Number of Linked Nodes 335
Number of Links 373
Number of Hubs 50
Number of Links mediated by Hubs 181
Number of Communities 15
Number of Nodes involved in Communities 71
Number of Links involved in Communities 90
Path Summary
Number Of Nodes in MetaPath 78
Number Of Links MetaPath 77
Number of Shortest Paths 78729
Length Of Smallest Path 3
Average Path Length 18.1625
Length of Longest Path 44
Minimum Path Strength 1.15
Average Path Strength 5.64271
Maximum Path Strength 22.93
Minimum Path Correlation 0.7
Average Path Correlation 0.942923
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 2.5641
Average % Of Corr. Nodes 48.7037
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 44.1744
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP25106
Sequence
>7SK5_Chain_R
VVDTVMCPN MPNKSVLLY TLSFIYIFI FVIGMIANS VVVWVNIQA 
KTTGYDTHC YILNLAIAD LWVVLTIPV WVVSLVQHN QWPMGELTC 
KVTHLIFSI NLFGSIFFL TCMSVDRYL SITYFTNTP SSRKKMVRR 
VVCILVWLL AFCVSLPDT YYLKTVTSN NETYCRSFY PEHSIKEWL 
IGMELVSVV LGFAVPFSI IAVFYFLLA RAISASSDQ EKHSSRKII 
FSYVVVFLV CWLPYHVAV LLDIFSILH YIPFTCRLE HALFTALHV 
TQCLSLVHC CVNPVLYSF INRNYRYEL MKA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7SK3AProteinChemokineACKR3Homo sapiensCXCL12--3.82022-07-2710.1126/sciadv.abn8063
7SK4AProteinChemokineACKR3Homo sapiensCXCL12_LRHQ--3.32022-07-2710.1126/sciadv.abn8063
7SK5AProteinChemokineACKR3Homo sapiensCXCL12--42022-07-2710.1126/sciadv.abn8063
7SK6AProteinChemokineACKR3Homo sapiensCXCL12_LRHQ--42022-07-2710.1126/sciadv.abn8063
7SK7AProteinChemokineACKR3Homo sapiensCXCL12CCX662-3.32022-07-2710.1126/sciadv.abn8063
7SK8AProteinChemokineACKR3Homo sapiensCXCL12CCX662-3.32022-07-2710.1126/sciadv.abn8063
7SK9AProteinChemokineACKR3Homo sapiens-CCX662-3.72022-07-2710.1126/sciadv.abn8063




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