Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x28 6.7775414
21x30 8.02333456
31x31 7.55133514
41x32 5.17583404
51x35 13.4275405
61x43 7.86583406
71x57 6.33583426
81x59 4.75667505
9I1 9.11133536
102x42 3.95278607
112x43 4.7525428
122x45 7.51083429
132x46 7.62083429
142x50 6.01778629
152x53 6.7525406
162x63 7.24333515
172x64 9.8775415
18E1x50 6.70083818
19E1x52 11.8858405
203x30 7.72417405
213x35 7.82167428
223x37 5.28778617
233x42 6.17267528
243x50 5.6425439
253x51 6.77833408
263x54 4.00333408
274x50 5.55429
28E2 14.59731113
29E2x51 7.4825413
305x40 6.30583415
315x51 7.38583406
325x58 6.6675408
335x60 4.48404
346x31 5.676577
356x33 5.55133537
366x45 6.3075469
376x48 8.70167469
386x51 7.52889617
396x52 8.23133518
406x55 10.9533515
41E3 8.41733541
427x28 5.98917442
437x49 7.62917429
447x53 7.01556629
458x48 4.81667435
46Lig 7.5821510
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
11x27 7x28 13.26913.73333NoYes012
21x31 Lig 17.74426.25667YesYes140
37x31 Lig 12.38575.46NoYes040
43x33 Lig 64.658923.13NoYes050
53x32 3x33 65.48887.03333NoNo065
62x53 3x32 1005.27667YesNo066
72x53 2x57 18.2354.46333YesNo067
81x42 2x57 10.63222.85NoNo077
92x53 3x35 99.857214.5YesYes068
102x50 3x35 80.52926.35667YesYes298
112x46 2x50 38.6748.69667YesYes299
122x46 7x53 49.38217.81333YesYes299
132x43 7x53 30.67427.58YesYes289
142x43 3x46 29.73273.29667YesNo089
152x39 3x46 28.7112.98NoNo079
162x39 3x50 24.27616.97667NoYes079
173x50 6x33 17.75767.01333YesYes397
186x33 8x49 13.24688.39333YesNo376
191x57 7x53 14.18379.97333YesYes269
201x57 8x50 10.80184.28667YesNo068
212x49 3x35 19.63595.96NoYes088
222x49 4x50 18.75255.76667NoYes089
232x45 4x50 12.066.40333YesYes299
242x45 4x46 12.283111.5467YesNo097
252x42 4x46 11.03824.19YesNo077
262x46 3x42 17.49435.27667YesYes298
272x50 7x49 39.80736.81YesYes299
282x63 E1x50 12.50617.07667YesYes158
293x28 E1x50 10.23075.81667NoYes058
30E2 Lig 24.5759.00667YesYes130
31E1x50 E2 15.50444.78YesYes183
32E1x50 E1x52 16.164715.3667YesYes085
332x63 E2x51 14.33543.90667YesYes153
34E2x50 E2x51 11.35064.76NoYes193
35E1x50 E2x50 10.119110.0133YesNo189
366x55 Lig 13.594817.8233YesYes150
373x38 3x42 10.19053.08NoYes078
387x45 7x49 55.55712.26NoYes099
396x48 7x45 53.75458.86333YesNo099
406x45 6x48 48.89576.07333YesYes699
415x54 6x45 44.17536.09NoYes079
423x47 5x54 38.25013.5NoNo097
433x47 5x58 36.12194.24NoYes098
445x58 6x38 31.77179.66667YesNo087
455x61 6x38 30.62954.41667NoNo087
463x51 5x61 15.28134.84YesNo088
473x54 5x61 15.53565.34333YesNo088
483x54 6x31 12.1094.38YesYes087
492x60 E2x51 28.938615.7933NoYes063
502x60 3x32 35.45264.45NoNo066
512x46 7x49 17.51228.69667YesYes299
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
1x271x313.876670NoYes1421
1x277x3117.23330NoNo1421
1x281x3113.051YesYes4421
1x28E2x525.916671YesNo4522
1x311x358.273331YesYes4512
1x31E2x526.31YesNo4512
1x31Lig6.256671YesYes4010
E1x49E29.80NoYes4321
E1x50E24.781YesYes8321
3x22E29.143331NoYes4321
3x323x337.033330NoNo6521
3x334x615.470NoNo5512
3x33Lig23.130NoYes5010
3x363x374.790NoYes7721
3x366x517.180NoYes7722
3x375x434.451YesNo7511
3x376x527.256671YesYes7812
3x376x555.141YesYes7511
3x37Lig7.191YesYes7010
4x56Lig4.813330NoYes5010
4x605x395.776670NoNo8521
4x64E25.180NoYes4321
E2E249.74331YesYes3311
5x33E24.761NoYes2321
5x36E28.433331NoYes4311
6x62E27.593331NoYes3321
E2Lig9.006671YesYes3010
5x336x6211.35331NoNo2322
5x36Lig11.32331NoYes4010
5x39Lig6.486670NoYes5010
5x406x558.436671YesYes5511
5x406x567.311YesNo5612
5x406x595.493331YesNo5511
5x40Lig3.983331YesYes5010
5x43Lig4.041NoYes5010
6x516x526.531YesYes7822
6x516x5515.091YesYes7521
6x526x558.276671YesYes8521
6x55Lig17.82331YesYes5010
6x587x3110.350NoNo4421
6x59Lig6.373331NoYes5010
7x31Lig5.460NoYes4010
4x57Lig3.586670NoYes7010
3x344x573.230NoNo5721
3x375x4612.91YesNo7512
5x35E22.386670NoYes3321
5x46Lig2.280NoYes4010
5x42Lig1.976670NoYes3010
5x455x461.603330NoNo4421

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
100.00Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
93.75Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
93.33Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
77.78Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
50.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
44.44Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
38.10Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
36.84Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
35.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
35.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
34.78Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
34.62Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
33.33Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
33.33Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
33.33Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
33.33Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
33.33Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
33.33Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
33.33Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
33.33Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
31.82Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
31.82Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
31.82Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
31.58Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
30.43Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
30.43Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
30.00Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
30.00Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
29.41Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
29.41Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
29.17Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
29.17Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
28.57Single4NTJAZD12834NTJ-P2Y12-AZD1283
28.57Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
28.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
28.00Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
28.00Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
27.78Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
27.78Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
27.59Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single6J21Aprepitant6J21-NK1-Aprepitant
27.27Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
27.27Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
27.27Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
27.27Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
27.27Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
26.92Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
26.47Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
26.47Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
26.32Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
26.32Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
26.32Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
26.32Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
26.32Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
26.09Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
26.09Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
26.09Single4PY02MeSATP4PY0-P2Y12-2MeSATP
26.09Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
26.09Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
26.09Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
26.09Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
26.09Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
25.93Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
25.93Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
25.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
25.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
25.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
25.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
25.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
25.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
25.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
25.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
25.00Single7VV6C48/807VV6-MRGPRX2-C48/80
25.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
25.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
25.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
25.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
25.00Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
25.00Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
25.00Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
25.00Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
24.14Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
24.14Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
24.14Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
24.14Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
24.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
24.00Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
24.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
23.81Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
23.81Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
23.81Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
23.81Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
23.81Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
23.81Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
23.81Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
23.53Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
23.33Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
23.33Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
23.08Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
23.08Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
23.08Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
23.08Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
23.08Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
23.08Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
23.08Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
23.08Consensussst_onOrthosteric Ligandsst2_on sst4_on
22.86Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
22.73Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
22.73Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
22.73Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
22.73Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
22.73Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
22.73Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.73Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.73Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
22.73Single8QOTNanobody E8QOT-μ-Nanobody E
22.73Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
22.58Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
22.22Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
22.22Single6HLOAprepitant6HLO-NK1-Aprepitant
22.22Single6ME9Ramelteon6ME9-MT2-Ramelteon
22.22Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
22.22Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
22.22Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.22Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
22.22Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
22.22Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
22.22Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
22.22Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
21.74Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
21.74Single5TZR-5TZR-FFA1 (GPR40)-MK8666
21.74Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
21.74Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
21.74Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.74Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
21.74Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
21.74Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
21.74Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
21.74Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
21.74Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
21.74Consensus5ht5_offOrthosteric Ligand5ht5a_off
21.74Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
21.74Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
21.43Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
21.43Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
21.43Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
21.43Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
21.05Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
21.05Single6HLLCP999946HLL-NK1-CP99994
21.05Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
21.05Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
21.05Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
21.05Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
21.05Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
20.83Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
20.83Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
20.83Single6HLPNetupitant6HLP-NK1-Netupitant
20.83Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
20.83Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
20.83Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
20.83Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
20.83Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
20.83Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
20.83Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Single8WU1KCA8WU1-CB1-KCA-Arrestin1
20.83Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
20.83Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
20.83Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
20.69Single7C61Ergotamine7C61-5-HT1B-Ergotamine
20.69Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.69Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
20.69Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
20.69Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
20.00Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
20.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
20.00Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
20.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
20.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
20.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
20.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
20.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
20.00Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
20.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
20.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
20.00Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
20.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
20.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
20.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
20.00Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
20.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
20.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
20.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
20.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
20.00Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
20.00Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
20.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.44Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
19.35Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Consensusclass-d_onOrthosteric Ligandste2_on
19.23Single3NY9PubChem 9131033NY9-β2-PubChem 913103
19.23Single5ZTYAM102575ZTY-CB2-AM10257
19.23Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
19.23Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
19.23Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
19.23Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
19.23Consensusclass-d_offOrthosteric Ligandste2_off
19.23Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
19.23Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
19.23Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
19.23Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
19.23Consensuslpl_onOrthosteric Ligands1p_on lpa_on
19.23Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.05Single3RZECidoxepin3RZE-H1-Cidoxepin
19.05Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
19.05Single4MBSMaraviroc4MBS-CCR5-Maraviroc
19.05Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
19.05Single5NLXZM2413855NLX-A2A-ZM241385-Na
19.05Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
19.05Single5UVIZM2413855UVI-A2A-ZM241385
19.05Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
19.05Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
19.05Single6MH8ZM2413856MH8-A2A-ZM241385
19.05Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
19.05Single7AROLUF58337ARO-A2A-LUF5833-Na
19.05Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
19.05Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
19.05Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
19.05Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
19.05Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
19.05Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Consensus5ht5_onOrthosteric Ligand5ht5a_on
19.05Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
19.05Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
19.05Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
19.05Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.75Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
18.75Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
18.75Consensusendothelin_onOrthosteric Ligandetb_on eta_on
18.75Consensusgi_class-dOrthosteric Ligandgi_ste
18.75Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.52Single4IARErgotamine4IAR-5-HT1B-Ergotamine
18.52Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single7QA8Peptide7QA8-STE2-Peptide
18.52Single7QA8Peptide7QA8-STE2-Peptide
18.52Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
18.52Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
18.52Consensusclass-d_offOrthosteric Ligandste2_off
18.52Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
18.52Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
18.52Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
18.18Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
18.18Single3EMLZM2413853EML-A2A-ZM241385
18.18Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
18.18Single4EJ4Naltrindole4EJ4-δ-Naltrindole
18.18Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
18.18Single5K2AZM2413855K2A-A2A-ZM241385-Na
18.18Single5VRAZM2413855VRA-A2A-ZM241385-Na
18.18Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
18.18Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
18.18Single6LPJZM2413856LPJ-A2A-ZM241385-Na
18.18Single6LPKZM2413856LPK-A2A-ZM241385-Na
18.18Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
18.18Single6S0LZM2413856S0L-A2A-ZM241385
18.18Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
18.18Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
18.18Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
18.18Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
18.18Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
18.18Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
18.18Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
18.18Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
18.18Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
18.18Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
18.18Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
18.18Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
18.18Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
18.18Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
18.18Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
18.18Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
18.18Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
18.18Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.18Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
18.18Single8IY6Endothelin-18IY6-ETB-Endothelin-1
18.18Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
18.18Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
18.18Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
18.18Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
18.18Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
18.18Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
18.18Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
18.18Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
18.18Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
18.18Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
18.18Consensustachykinin_offOrthosteric Ligandnk1_off
17.86Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
17.86Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
17.86Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
17.86Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
17.86Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
17.86Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
17.86Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
17.39Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
17.39Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
17.39Single5IUAQ274563485IUA-A2A-Q27456348-Na
17.39Single5NM2ZM2413855NM2-A2A-ZM241385-Na
17.39Single5TVNLSD5TVN-5-HT2B-LSD
17.39Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
17.39Single5XPRBosentan5XPR-ETB-Bosentan
17.39Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
17.39Single6LPLZM2413856LPL-A2A-ZM241385-Na
17.39Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
17.39Single6S0QZM2413856S0Q-A2A-ZM241385
17.39Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
17.39Single6WQAZM2413856WQA-A2A-ZM241385-Na
17.39Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
17.39Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
17.39Single7RM5ZM2413857RM5-A2A-ZM241385-Na
17.39Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
17.39Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
17.39Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
17.39Single7WC6LSD7WC6-5-HT2A-LSD
17.39Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
17.39Single8FYNZM2413858FYN-A2A-ZM241385-Na
17.39Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
17.39Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
17.39Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
17.39Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
17.39Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
17.39Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
17.39Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
17.39Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
17.24Single3OE0CVX153OE0-CXCR4-CVX15
17.24Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
17.24Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
17.24Consensusangiotensin_onOrthosteric Ligandat1_on
17.24Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
17.24Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
17.24Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
17.24Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
17.14Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
16.67Single2YDVNECA2YDV-A2A-NECA
16.67Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
16.67Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
16.67Single4U15Tiotropium4U15-M3-Tiotropium
16.67Single4UHRCGS216804UHR-A2A-CGS21680
16.67Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
16.67Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
16.67Single5G53NECA5G53-A2A-NECA-Gs
16.67Single5V54Methiothepin5V54-5-HT1B-Methiothepin
16.67Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
16.67Single5XR8AM8415XR8-CB1-AM841
16.67Single5XRAAM115425XRA-CB1-AM11542
16.67Single6E59L-7607356E59-NK1-L-760735
16.67Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
16.67Single6J20Aprepitant6J20-NK1-Aprepitant
16.67Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.67Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.67Single6OL9Tiotropium6OL9-M5-Tiotropium
16.67Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
16.67Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
16.67Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
16.67Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
16.67Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
16.67Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
16.67Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
16.67Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
16.67Single7TUYGSK682753A7TUY-GPR183-GSK682753A
16.67Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
16.67Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
16.67Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
16.67Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
16.67Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
16.67Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
16.67Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
16.67Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
16.67Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensus5ht1_offOrthosteric Ligand5ht1b_off
16.67Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
16.67Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
16.67Consensusa2_onOrthosteric Liganda2a_on a2b_on
16.67Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
16.67Consensusclass-d_onOrthosteric Ligandste2_on
16.67Consensusgi_class-dOrthosteric Ligandgi_ste
16.67Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
16.67Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
16.67Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
16.67Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
16.67Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
16.67Consensushistamine_offOrthosteric Ligandh1_off
16.67Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Consensuslpa_offOrthosteric Ligandlpa1_off
16.67Consensuslpa_onOrthosteric Ligandlpa1_on
16.67Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
16.67Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
16.67Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
16.67Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusrelaxin_onOrthosteric Ligandrxfp4_on
16.67Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
16.67Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
16.22Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
16.13Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
16.13Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
16.13Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
16.13Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
16.13Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
16.13Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
16.00Single5CXVTiotropium5CXV-M1-Tiotropium
16.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
16.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
16.00Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
16.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
16.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
16.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
16.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
16.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
16.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
16.00Single7YITNalfurafine7YIT-κ-Nalfurafine
16.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
16.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
16.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
16.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
16.00Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
16.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
16.00Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
16.00Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
16.00Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
16.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
16.00Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
16.00Consensusgs_steroidOrthosteric Ligandgs_bileacid
16.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
16.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
16.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
16.00Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
16.00Consensusnts_offOrthosteric Ligandnts1_off
16.00Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
15.79Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
15.79Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
15.79Single6ME5Agomelatine6ME5-MT1-Agomelatine
15.79Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
15.62Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
15.62Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
15.62Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.62Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
15.62Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
15.62Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
15.62Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
15.38Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
15.38Single6IBLArformoterol6IBL-β1-Arformoterol
15.38Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
15.38Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
15.38Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
15.38Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
15.38Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
15.38Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
15.38Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
15.38Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
15.38Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
15.38Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
15.38Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.38Consensusorexin_onOrthosteric Ligandox2_on
15.38Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
15.38Consensussteroid_onOrthosteric Ligandbileacid_on
15.15Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.15Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
15.15Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
15.00Single3PBLEticlopride3PBL-D3-Eticlopride
15.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
15.00Single7SRQLSD7SRQ-5-HT2B-LSD
15.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
15.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
15.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
15.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
15.00Single8GH1Epinephrine8GH1-β2-Epinephrine
15.00Single8J6QCompound 9n8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
15.00Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
15.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
15.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
15.00Consensushca2_on_alloOther Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
14.81Single4UG2CGS216804UG2-A2A-CGS21680
14.81Single6PT3DPI-2876PT3-δ-DPI-287
14.81Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
14.81Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
14.81Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
14.81Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81Single7XN9L-054,5227XN9-SST2-L-054,522
14.81Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
14.81Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
14.81Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
14.81Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
14.81Consensuslpl_offOrthosteric Ligands1p_off lpa_off
14.81Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.71Single6IGLIRL16206IGL-ETB-IRL1620
14.71Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
14.71Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
14.71Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
14.29Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
14.29Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
14.29Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
14.29Single3PWHZM2413853PWH-A2A-ZM241385
14.29Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
14.29Single5GLHEndothelin-15GLH-ETB-Endothelin-1
14.29Single5K2DZM2413855K2D-A2A-ZM241385
14.29Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
14.29Single6AKXA4R6AKX-CCR5-A4R
14.29Single6AKYMaraviroc6AKY-CCR5-Maraviroc
14.29Single6B73PubChem 1319551386B73-κ-PubChem 131955138
14.29Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
14.29Single6IGKEndothelin-36IGK-ETB-Endothelin-3
14.29Single6JZHZM2413856JZH-A2A-ZM241385-Na
14.29Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
14.29Single6PS7ZM2413856PS7-A2A-ZM241385-Na
14.29Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
14.29Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
14.29Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
14.29Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
14.29Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
14.29Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
14.29Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
14.29Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
14.29Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
14.29Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
14.29Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
14.29Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
14.29Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
14.29Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
14.29Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GNGIstradefylline8GNG-A2A-Istradefylline
14.29Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
14.29Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
14.29Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2
14.29Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
14.29Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
14.29Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
14.29Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
14.29Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
14.29Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
14.29Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
14.29Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
14.29Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Consensusgt_class-aOrthosteric Ligandgt_opsin
14.29Consensusgt_opsinOrthosteric Ligandgt_sensory
14.29Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
14.29Consensusmglu_onOther Ligandmglu2_on mglu4_on
13.89Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
13.89Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
13.89Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
13.79Single3QAKUK-4320973QAK-A2A-UK-432097
13.79Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
13.79Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
13.79Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
13.79Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.79Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
13.64Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
13.64Single3REYPubChem 56973REY-A2A-PubChem 5697
13.64Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
13.64Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
13.64Single5IU4ZM2413855IU4-A2A-ZM241385-Na
13.64Single5IU7Q274563465IU7-A2A-Q27456346-Na
13.64Single5IUBQ274563445IUB-A2A-Q27456344-Na
13.64Single5JTBZM2413855JTB-A2A-ZM241385
13.64Single5K2BZM2413855K2B-A2A-ZM241385-Na
13.64Single5K2CZM2413855K2C-A2A-ZM241385-Na
13.64Single5NM4ZM2413855NM4-A2A-ZM241385-Na
13.64Single6AQFZM2413856AQF-A2A-ZM241385
13.64Single6DS0Ly2660976DS0-5-HT2B-Ly266097
13.64Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
13.64Single6PS4ICI 118-5516PS4-β2-ICI 118-551
13.64Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
13.64Single6TPNHTL66416TPN-OX2-HTL6641
13.64Single6VI4JDTic6VI4-κ-JDTic
13.64Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
13.64Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
13.64Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
13.64Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
13.64Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.64Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.64Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
13.64Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
13.64Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
13.64Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
13.64Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
13.64Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
13.64Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
13.64Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.64Single8GGKEpinephrine8GGK-β2-Epinephrine
13.64Single8GGLEpinephrine8GGL-β2-Epinephrine
13.64Single8GGMEpinephrine8GGM-β2-Epinephrine
13.64Single8GGPEpinephrine8GGP-β2-Epinephrine
13.64Single8GGQEpinephrine8GGQ-β2-Epinephrine
13.64Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
13.64Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single8IYXYL-3658IYX-GPR34-YL-365
13.64Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
13.64Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.64Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.64Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
13.64Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
13.64Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
13.64Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
13.64Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
13.64Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
13.64Consensussensory_offOrthosteric Ligandopsin_off
13.51Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
13.51Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.33Single5WF5UK-4320975WF5-A2A-UK-432097
13.33Single6PT2KGCHM076PT2-δ-KGCHM07
13.33Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single7XNACYN1548067XNA-SST2-CYN154806
13.33Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
13.33Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
13.33Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.33Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
13.33Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
13.04Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
13.04Single2Y02Carmoterol2Y02-β1-Carmoterol
13.04Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
13.04Single3NY8ICI 118-5513NY8-β2-ICI 118-551
13.04Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
13.04Single4EIYZM2413854EIY-A2A-ZM241385-Na
13.04Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
13.04Single4MQSIperoxo4MQS-M2-Iperoxo
13.04Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
13.04Single4U14Tiotropium4U14-M3-Tiotropium
13.04Single5IU8Q274563475IU8-A2A-Q27456347-Na
13.04Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
13.04Single5OLGZM2413855OLG-A2A-ZM241385-Na
13.04Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
13.04Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
13.04Single5UENDU1725UEN-A1-DU172
13.04Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
13.04Single6DRXLisuride6DRX-5-HT2B-Lisuride
13.04Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
13.04Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
13.04Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
13.04Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
13.04Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
13.04Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
13.04Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
13.04Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
13.04Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
13.04Single7BU7BI1671077BU7-β1-BI167107
13.04Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
13.04Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
13.04Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Single7PYRPSB-21157PYR-A2A-PSB-2115
13.04Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
13.04Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
13.04Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
13.04Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
13.04Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
13.04Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
13.04Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
13.04Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
13.04Single8CU6LJ-45178CU6-A2A-LJ-4517
13.04Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
13.04Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
13.04Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
13.04Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
13.04Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
13.04Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.04Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.04Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.04Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.04Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.04Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.04Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.04Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.04Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.04Single8GGJEpinephrine8GGJ-β2-Epinephrine
13.04Single8GGNEpinephrine8GGN-β2-Epinephrine
13.04Single8GGOEpinephrine8GGO-β2-Epinephrine
13.04Single8GGUEpinephrine8GGU-β2-Epinephrine
13.04Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
13.04Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
13.04Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
13.04Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
13.04Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
13.04Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.04Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.04Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
13.04Single8X63Mepyramine8X63-H1-Mepyramine
13.04Single8X64Desloratadine8X64-H1-Desloratadine
13.04Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
13.04Consensusa2_offOrthosteric Liganda2a_off
13.04Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
13.04Consensusadenosine_onOrthosteric Liganda1_on a2_on
13.04Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
13.04Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
13.04Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
13.04Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
13.04Consensusblt_onOrthosteric Ligandblt1_on
13.04Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
13.04Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
13.04Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
13.04Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
13.04Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
13.04Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
13.04Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
13.04Consensusleuko_onOrthosteric Ligandblt_on
13.04Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
13.04Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
13.04Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
13.04Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
13.04Consensusnucleotide_onOrthosteric Ligandadenosine_on
13.04Consensustar_onOrthosteric Ligandta1_on
12.90Single6JODAngiotensin II6JOD-AT2-Angiotensin II
12.90Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
12.90Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
12.90Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
12.90Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
12.90Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
12.50Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
12.50Single5C1MBU725C1M-μ-BU72
12.50Single5N2SPSB365N2S-A1-PSB36
12.50Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
12.50Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
12.50Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
12.50Single6D26Fevipiprant6D26-DP2-Fevipiprant
12.50Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
12.50Single6E67BI1671076E67-β2-BI167107-Gs (fused)
12.50Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
12.50Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
12.50Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
12.50Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
12.50Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
12.50Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
12.50Single6PS6Timolol6PS6-β2-Timolol
12.50Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
12.50Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.50Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
12.50Single6Z4SSR486926Z4S-NTS1-SR48692
12.50Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
12.50Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
12.50Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
12.50Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
12.50Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
12.50Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
12.50Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
12.50Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
12.50Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
12.50Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
12.50Single7XKAEpinephrine7XKA-β2-Epinephrine
12.50Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
12.50Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
12.50Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
12.50Single8GNEKW-63568GNE-A2A-KW-6356-Na
12.50Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
12.50Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
12.50Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
12.50Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
12.50Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
12.50Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
12.50Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
12.50Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
12.50Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
12.50Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
12.50Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
12.50Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
12.50Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
12.50Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
12.50Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
12.50Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
12.50Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
12.50Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
12.50Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
12.12Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
12.12Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
12.12Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.12Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.12Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
12.00Single3P0GBI1671073P0G-β2-BI167107
12.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
12.00Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
12.00Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
12.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
12.00Single4DJHJDTic4DJH-κ-JDTic
12.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
12.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
12.00Single5V56TC1145V56-SMO-TC114
12.00Single5X93K-87945X93-ETB-K-8794
12.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
12.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
12.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
12.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
12.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
12.00Single6OS1TRV0266OS1-AT1-TRV026
12.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
12.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
12.00Single6WGTLSD6WGT-5-HT2A-LSD
12.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
12.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
12.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
12.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
12.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
12.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
12.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
12.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
12.00Single7PX4PSB-21137PX4-A2A-PSB-2113
12.00Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
12.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
12.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
12.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
12.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Single8E0GBU728E0G-μ-BU72
12.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
12.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
12.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
12.00Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
12.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
12.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
12.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
12.00Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
12.00Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
12.00Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
12.00Consensuschemerin_onOrthosteric Ligandcml1_on
12.00Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
12.00Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
12.00Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
12.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
12.00Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
12.00Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
12.00Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
12.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
12.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
12.00Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
12.00Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
12.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
11.76Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
11.76Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
11.76Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
11.76Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
11.76Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
11.63Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
11.54Single4AMIBucindolol4AMI-β1-Bucindolol
11.54Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
11.54Single4LDEBI1671074LDE-β2-BI167107
11.54Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
11.54Single4XEENeurotensin4XEE-NTS1-Neurotensin
11.54Single4XESNeurotensin4XES-NTS1-Neurotensin
11.54Single6MXTSalmeterol6MXT-β2-Salmeterol
11.54Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
11.54Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
11.54Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
11.54Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.54Single6ZG4HTL00099366ZG4-M1-HTL0009936
11.54Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
11.54Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
11.54Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
11.54Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.54Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
11.54Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.54Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
11.54Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
11.54Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single8JJ8Formoterol8JJ8-β2-Formoterol
11.54Single8JJLOlodaterol8JJL-β2-Olodaterol
11.54Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
11.54Single8JWZAB9288JWZ-A2A-AB928-Na
11.54Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
11.54Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
11.54Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
11.54Consensusclass-b2_onOrthosteric Ligandadgrg_on
11.54Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
11.54Consensusdp_offOrthosteric Liganddp2_off
11.54Consensusgi_class-fOther Ligandgi_frizzled
11.54Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.54Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.54Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
11.54Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
11.54Consensusnts_onOrthosteric Ligandnts1_on
11.54Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
11.54Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.43Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
11.43Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
11.43Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
11.11Single4BUONeurotensin4BUO-NTS1-Neurotensin
11.11Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
11.11Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
11.11Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
11.11Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
11.11Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
11.11Single6H7LDobutamine6H7L-β1-Dobutamine
11.11Single6K1QIRL25006K1Q-ETB-IRL2500
11.11Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single7EZCUKA7EZC-A2A-UKA
11.11Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
11.11Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
11.11Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.11Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
11.11Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
11.11Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
11.11Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
11.11Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
11.11Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
11.11Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
11.11Single8PWNTheophylline8PWN-A2A-Theophylline
11.11Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
11.11Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
11.11Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
11.11Consensusclass-c_onOther Ligandgabab_on mglu_on
11.11Consensusendothelin_offOrthosteric Ligandetb_off
11.11Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
11.11Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
11.11Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
11.11Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
11.11Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
10.71Single5WF6UK-4320975WF6-A2A-UK-432097
10.71Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
10.71Single6KNMJN241-96KNM-Apelin-JN241-9
10.71Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
10.71Single7SK9CCX6627SK9-ACKR3-CCX662
10.71Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
10.71Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
10.71Single8X5YAstemizole8X5Y-H1-Astemizole
10.71Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
10.71Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
10.71Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Consensusgs_class-b2Orthosteric Ligandgs_adgr
10.71Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
10.71Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
10.53Single3RFMCaffeine3RFM-A2A-Caffeine
10.53Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
10.53Single6TQ9SB-4081246TQ9-OX1-SB-408124
10.53Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
10.53Single8A2OTheophylline8A2O-A2A-Theophylline-Na
10.53Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
10.53Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
10.34Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
10.34Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
10.34Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
10.34Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
10.34Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
10.34Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
10.34Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
10.26Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
10.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
10.00Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
10.00Single3UZAGTPL92363UZA-A2A-GTPL9236
10.00Single4XNWMRS25004XNW-P2Y1-MRS2500
10.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
10.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
10.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
10.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
10.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
10.00Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
10.00Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
10.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
10.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
10.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
10.00Single7SHEPI; PE7SHE-GPR158-PI; PE
10.00Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
10.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
10.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
10.00Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
10.00Single8GGREpinephrine8GGR-β2-Epinephrine
10.00Single8GGZEpinephrine8GGZ-β2-Epinephrine
10.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
10.00Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
10.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
10.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
10.00Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
10.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
10.00Consensussst_offOrthosteric Ligandsst2_off
9.76Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
9.68Single6W25SHU91196W25-MC4-SHU9119-Ca
9.68Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
9.68Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.68Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
9.68Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
9.68Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
9.68Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
9.68Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
9.68Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
9.68Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.68Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
9.52Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
9.52Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
9.52Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
9.52Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
9.52Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
9.52Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
9.52Single6TP4ACT-4622066TP4-OX1-ACT-462206
9.52Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
9.52Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.52Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
9.52Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
9.52Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
9.52Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
9.52Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
9.52Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
9.52Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
9.52Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
9.52Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
9.52Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.52Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.52Single8GGSEpinephrine8GGS-β2-Epinephrine
9.52Single8GGYEpinephrine8GGY-β2-Epinephrine
9.52Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
9.52Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
9.52Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.52Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
9.52Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
9.52Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
9.52Consensusgo_proteinOrthosteric Ligandgo_chemokine
9.52Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
9.52Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
9.52Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
9.38Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
9.38Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
9.30Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
9.09Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
9.09Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
9.09Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
9.09Single4BWBNeurotensin4BWB-NTS1-Neurotensin
9.09Single5DHHSB-6121115DHH-NOP-SB-612111
9.09Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
9.09Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
9.09Single5WS3EMPA5WS3-OX2-EMPA
9.09Single5ZKQABT-4915ZKQ-PAF-ABT-491
9.09Single6KUXRS-799486KUX-α2a-RS-79948
9.09Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
9.09Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
9.09Single6TODEMPA6TOD-OX1-EMPA-Na
9.09Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
9.09Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
9.09Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
9.09Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
9.09Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
9.09Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.09Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.09Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
9.09Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
9.09Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
9.09Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
9.09Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
9.09Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
9.09Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
9.09Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
9.09Single7XRRLemborexant7XRR-OX2-Lemborexant
9.09Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
9.09Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
9.09Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
9.09Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
9.09Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
9.09Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
9.09Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
9.09Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
9.09Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
9.09Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.09Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.09Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.09Single8GGVEpinephrine8GGV-β2-Epinephrine
9.09Single8GGWEpinephrine8GGW-β2-Epinephrine
9.09Single8GGXEpinephrine8GGX-β2-Epinephrine
9.09Single8GH0Epinephrine8GH0-β2-Epinephrine
9.09Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
9.09Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
9.09Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.09Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.09Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.09Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.09Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.09Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
9.09Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.09Consensusalpha1_onOrthosteric Ligandalpha1a_on
9.09Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
9.09Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
9.09Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
9.09Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
9.09Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
9.09Consensusclass-f_offOrthosteric Ligandsmo_off
9.09Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
9.09Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
9.09Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
9.09Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
9.09Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
9.09Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
9.09Consensusorexin_offOrthosteric Ligandox2_off ox1_off
8.89Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
8.82Single4XT3Fractalkine4XT3-US28-Fractalkine
8.82Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
8.82Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
8.82Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
8.82Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
8.82Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
8.70Single2YDOAdenosine2YDO-A2A-Adenosine
8.70Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
8.70Single4ZJCSB-6740424ZJC-OX1-SB-674042
8.70Single6A94Zotepine6A94-5-HT2A-Zotepine
8.70Single6IQLL7458706IQL-D4-L745870
8.70Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
8.70Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
8.70Single6TPGEMPA6TPG-OX2-EMPA
8.70Single6TPKRetosiban6TPK-OT-Retosiban
8.70Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
8.70Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
8.70Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
8.70Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
8.70Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
8.70Single6ZINSR486926ZIN-NTS1-SR48692
8.70Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.70Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
8.70Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
8.70Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
8.70Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
8.70Single7T32ZM2413857T32-A2A-ZM241385
8.70Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
8.70Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
8.70Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
8.70Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
8.70Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
8.70Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
8.70Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
8.70Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
8.70Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
8.70Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
8.70Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
8.70Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
8.70Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
8.70Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
8.70Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
8.70Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
8.70Single8GGIEpinephrine8GGI-β2-Epinephrine
8.70Single8GGTEpinephrine8GGT-β2-Epinephrine
8.70Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
8.70Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
8.70Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
8.70Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
8.70Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
8.70Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
8.70Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
8.70Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
8.70Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
8.70Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
8.70Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
8.70Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
8.70Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
8.70Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
8.70Consensusvasopressin-ot_offOrthosteric Ligandot_off
8.57Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
8.57Consensusgo_class-b1Orthosteric Ligandgo_crf
8.57Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
8.57Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
8.33Single2Y01Dobutamine2Y01-β1-Dobutamine
8.33Single2Y04Salbutamol2Y04-β1-Salbutamol
8.33Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
8.33Single4DAJTiotropium4DAJ-M3-Tiotropium
8.33Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
8.33Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
8.33Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
8.33Single5DSGTiotropium5DSG-M4-Tiotropium
8.33Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
8.33Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
8.33Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
8.33Single6GPSMK08126GPS-CCR2-MK0812
8.33Single6H7MSalbutamol6H7M-β1-Salbutamol
8.33Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single6PS1Timolol6PS1-β2-Timolol
8.33Single6TOTLemborexant6TOT-OX1-Lemborexant
8.33Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
8.33Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
8.33Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
8.33Single7UL4Alvimopan7UL4-μ-Alvimopan
8.33Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
8.33Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
8.33Single7WC7Lisuride7WC7-5-HT2A-Lisuride
8.33Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
8.33Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
8.33Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
8.33Single8JJOAlprenolol8JJO-β2-Alprenolol
8.33Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
8.33Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
8.33Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
8.33Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
8.33Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
8.33Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
8.33Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
8.33Consensusgi_hcarOrthosteric Ligandgi_hca
8.33Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
8.33Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
8.33Consensushistamine_onOrthosteric Ligandh1_on h4_on
8.33Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
8.00Single2Y00Dobutamine2Y00-β1-Dobutamine
8.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
8.00Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
8.00Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
8.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
8.00Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
8.00Single5WIUNemonapride5WIU-D4-Nemonapride
8.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
8.00Single5WQCEMPA5WQC-OX2-EMPA
8.00Single6GPXMK08126GPX-CCR2-MK0812
8.00Single6TP6Filorexant6TP6-OX1-Filorexant
8.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
8.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
8.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
8.00Single7SINNPS-21437SIN-CaS-NPS-2143
8.00Single7SINNPS-21437SIN-CaS-NPS-2143
8.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
8.00Single8EA0Iperoxo8EA0-M3-Iperoxo
8.00Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.00Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
8.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
8.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
8.00Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
8.00Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
8.00Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
7.89Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
7.69Single4BV0Neurotensin4BV0-NTS1-Neurotensin
7.69Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
7.69Single5V57TC1145V57-SMO-TC114
7.69Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
7.69Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
7.69Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
7.69Single6TQ7SB-3348676TQ7-OX1-SB-334867
7.69Single7EPENAM5637EPE-mGlu-NAM563
7.69Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
7.69Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
7.69Single7W41PD1762527W41-BB2-PD176252
7.69Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
7.69Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
7.69Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
7.69Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
7.69Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
7.69Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
7.69Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
7.69Consensusbombesin_offOrthosteric Ligandbb2_off
7.69Consensuscck_onOrthosteric Ligandccka_on cckb_on
7.41Single4N4WSANT-14N4W-SMO-SANT-1
7.41Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
7.41Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
7.41Single6OS2TRV0266OS2-AT1-TRV026
7.41Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.41Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.41Single6YVRNTS8-136YVR-NTS1-NTS8-13
7.41Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
7.41Single7SHEPI; PE7SHE-GPR158-PI; PE
7.41Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.41Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
7.41Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.41Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.41Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
7.41Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
7.41Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
7.41Consensuschemokine_offOrthosteric Ligandcxcr_off
7.41Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
7.41Consensuscxcr_offOrthosteric Ligandcxcr4_off
7.41Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
7.32Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
7.32Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
7.32Consensuspth_onOrthosteric Ligandpth1_on pth2_on
7.14Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
7.14Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
7.14Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
7.14Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
7.14Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
7.14Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
7.14Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
7.14Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
7.14Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
6.98Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
6.98Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
6.90Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
6.90Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
6.90Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.90Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
6.90Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
6.90Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
6.90Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
6.90Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
6.90Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
6.67Single4XT1Fractalkine4XT1-US28-Fractalkine
6.67Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
6.67Single7F8XNN90567F8X-CCKA-NN9056
6.67Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
6.67Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
6.67Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
6.67Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
6.45Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
6.45Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
6.45Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
6.45Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
6.45Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.45Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
6.25Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
6.06Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
6.06Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
6.06Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
6.06Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
6.06Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
6.06Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
6.06Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
6.06Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
5.88Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
5.88Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
5.88Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
5.88Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
5.88Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
5.88Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
5.88Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
5.88Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
5.71Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
5.71Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
5.71Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
5.71Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
5.71Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
5.71Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
5.71Single7SK3CXCL127SK3-ACKR3-CXCL12
5.71Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
5.71Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
5.71Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
5.71Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
5.71Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
5.56Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
5.56Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
5.56Single5MZPCaffeine5MZP-A2A-Caffeine-Na
5.56Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
5.56Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
5.56Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
5.56Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
5.56Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
5.56Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
5.56Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
5.56Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
5.56Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
5.56Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
5.56Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
5.41Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
5.41Single6LMLGlucagon6LML-Glucagon-Glucagon
5.41Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
5.41Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
5.41Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
5.41Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
5.41Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
5.41Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
5.41Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
5.41Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.41Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
5.41Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
5.26Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
5.26Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
5.26Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
5.26Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
5.26Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.26Single7WC4Serotonin7WC4-5-HT2A-Serotonin
5.26Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
5.26Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.26Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
5.26Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
5.13Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
5.13Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.13Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
5.13Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
5.13Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
5.13Consensusglp_onOrthosteric Ligandglp1_on glp2_on
5.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
5.00Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
5.00Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
5.00Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
5.00Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
5.00Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
5.00Consensussensory_onOrthosteric Ligandopsin_on
4.88Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
4.88Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
4.88Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
4.88Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
4.76Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
4.76Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
4.76Single3OE6IT1t3OE6-CXCR4-IT1t
4.76Single6LI0GTPL98046LI0-GPR52-GTPL9804
4.76Single6OBAGTPL110746OBA-β2-(S)-Alprenolol-GTPL11074
4.76Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
4.76Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
4.76Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
4.76Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
4.76Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single8WG8Peptide8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Consensusbeta2_off_alloOther Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
4.76Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
4.55Single3OE9IT1t3OE9-CXCR4-IT1t
4.55Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
4.55Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
4.55Single4O9RCyclopamine4O9R-SMO-Cyclopamine
4.55Single5L7IVismodegib5L7I-SMO-Vismodegib
4.55Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
4.55Single7UL2SR486927UL2-NTS1-SR48692-Na
4.55Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
4.55Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
4.55Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
4.55Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
4.55Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
4.55Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
4.55Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
4.55Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
4.55Single8K5BNiacin8K5B-HCA2-Niacin
4.55Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
4.55Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.55Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
4.55Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusclass-t_onOrthosteric Ligandtaste2_on
4.55Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
4.55Consensusgs_class-tOrthosteric Ligandgs_taste
4.55Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
4.55Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
4.55Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
4.55Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.55Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
4.44Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
4.44Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
4.35Single3ODUIT1t3ODU-CXCR4-IT1t
4.35Single4QINSAG1.54QIN-SMO-SAG1.5
4.35Single4S0VSuvorexant4S0V-OX2-Suvorexant
4.35Single5U09Taranabant5U09-CB1-Taranabant
4.35Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
4.35Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
4.35Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.35Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.35Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
4.35Single6TPJSuvorexant6TPJ-OX2-Suvorexant
4.35Single7BR3Elagolix7BR3-GnRH1-Elagolix
4.35Single7F8ULintitript7F8U-CCKA-Lintitript
4.35Single7F8YDevazepide7F8Y-CCKA-Devazepide
4.35Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
4.35Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
4.35Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
4.35Single7WV9ZCZ0117WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
4.35Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
4.35Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
4.35Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
4.35Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single8IWESpermidine8IWE-TAAR9-Spermidine
4.35Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
4.35Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
4.35Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
4.35Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
4.35Consensuscb1_on_alloOther Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
4.35Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
4.35Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
4.35Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.26Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
4.17Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
4.17Single5O9HNDT95137275O9H-C5a1-NDT9513727
4.17Single6TP3Nemorexant6TP3-OX1-Nemorexant
4.17Single6V9SGTPL114036V9S-OX1-GTPL11403
4.17Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.17Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
4.17Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
4.17Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
4.17Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
4.17Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.17Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
4.17Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
4.17Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.17Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
4.17Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
4.17Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
4.17Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
4.17Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
4.17Single8K5CAcipimox8K5C-HCA2-Acipimox
4.17Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
4.17Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
4.17Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
4.17Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
4.17Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
4.17Consensusgi_class-fOrthosteric Ligandgi_frizzled
4.17Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.17Consensusgnrh_offOrthosteric Ligandgnrh1_off
4.17Consensushca_onOrthosteric Ligandhca2_on hca3_on
4.17Consensushcar_onOrthosteric Ligandhca_on
4.17Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
4.17Consensuss1p_offOrthosteric Ligands1p1_off
4.00Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
4.00Single4YAYZD-71554YAY-AT1-ZD-7155
4.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
4.00Single5T04Neurotensin5T04-NTS1-Neurotensin
4.00Single5TGZAM65385TGZ-CB1-AM6538
4.00Single6C1RAvacopan; Na6C1R-C5a1-PMX53-Avacopan; Na
4.00Single6D27CAY104716D27-DP2-CAY10471
4.00Single6IIVDaltroban6IIV-TP-Daltroban
4.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
4.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
4.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
4.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
4.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
4.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
4.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
4.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
4.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
4.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
4.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
4.00Consensusc5a1_off_ortoalloOther Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
4.00Consensuscck_offOrthosteric Ligandccka_off
4.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
4.00Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
4.00Consensushcar_offOrthosteric Ligandsuccinate_off
4.00Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
4.00Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
4.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
4.00Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
3.85Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
3.85Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
3.85Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
3.85Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
3.85Single7C4SS1P7C4S-S1P3-S1P
3.85Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
3.85Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
3.85Single7YXAONO-54306087YXA-S1P5-ONO-5430608
3.85Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
3.85Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
3.85Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
3.85Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
3.85Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
3.85Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
3.85Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
3.85Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
3.85Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
3.85Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
3.85Consensusep_offOrthosteric Ligandep4_off
3.70Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
3.70Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
3.70Single7P2L4YI7P2L-mGlu5-4YI
3.70Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
3.70Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
3.70Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
3.70Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
3.70Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
3.70Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
3.70Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
3.70Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
3.57Single6A93Risperidone6A93-5-HT2A-Risperidone
3.57Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
3.57Single6CM4Risperidone6CM4-D2-Risperidone
3.57Single6IIURamatroban6IIU-TP-Ramatroban
3.57Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
3.57Single7DFPSpiperone7DFP-D2-Spiperone
3.57Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
3.57Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
3.57Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
3.57Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
3.57Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
3.57Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
3.57Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
3.57Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
3.57Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
3.57Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
3.45Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
3.45Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
3.45Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
3.45Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
3.45Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
3.45Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33Single5EE7MK08935EE7-Glucagon-MK0893
3.33Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.23Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
3.23Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
3.23Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
3.23Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
3.12Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.03Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
2.94Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
2.94Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
2.86Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
2.78Single6FJ3PTH6FJ3-PTH1-PTH
2.78Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
2.78Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
2.78Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
2.70Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
2.70Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
2.63Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
2.63Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.63Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
2.56Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
2.56Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.56Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.56Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
2.44Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.44Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.44Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
2.38Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.38Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
2.38Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.27Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.13Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3

Consensus Members
Id Members
cyslt2_off 6RZ6-CysLT2-ONO-2570366
6RZ9-CysLT2-ONO-2770372
6RZ8-CysLT2-ONO-2080365
Net Summary
Imin 3.74
Number of Linked Nodes 253
Number of Links 291
Number of Hubs 46
Number of Links mediated by Hubs 181
Number of Communities 7
Number of Nodes involved in Communities 55
Number of Links involved in Communities 75
Path Summary
Number Of Nodes in MetaPath 52
Number Of Links MetaPath 51
Number of Shortest Paths 40347
Length Of Smallest Path 3
Average Path Length 12.6871
Length of Longest Path 27
Minimum Path Strength 0.495
Average Path Strength 7.51899
Maximum Path Strength 18.6811
Minimum Path Correlation 0.7
Average Path Correlation 0.911442
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.16667
Average % Of Corr. Nodes 46.93
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.7621
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
leuko_offblt_off
cyslt_off



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