Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 5.934284
2A:A:H41 7.655406
3A:A:L44 8.89429
4A:A:L46 4.225428
5A:A:N50 6.6225189
6A:A:S51 3.3475409
7A:A:V214 4.4654176
8A:A:F219 7.2954178
9A:A:H220 6.285427
10A:A:M221 4.3408
11A:A:F222 7.486527
12A:A:Q227 5.565629
13A:A:K233 6.884529
14A:A:W234 6.30143729
15A:A:C237 5.362528
16A:A:F238 7.73629
17A:A:I244 3.5875428
18A:A:I245 4.8125157
19A:A:D249 11.964188
20A:A:Y253 5.26578
21A:A:F273 5.513336309
22A:A:W277 9.5645306
23A:A:W281 11.5667625
24A:A:F290 5.793336159
25A:A:N292 5.4825409
26A:A:K293 7.384189
27A:A:Q294 5.16476
28A:A:Y311 5.8925476
29A:A:F312 4.154578
30A:A:F315 13.4725406
31A:A:Y318 7.9325476
32A:A:P321 4.56675
33A:A:D331 4.5054314
34A:A:Y339 7.32333673
35A:A:F340 8.226577
36A:A:R342 7.266574
37A:A:E344 6.235475
38A:A:F345 9.2625408
39A:A:S349 4.385407
40A:A:Y360 9.675408
41A:A:F363 7.994575
42A:A:T364 6.415159
43A:A:D368 4.81254159
44A:A:N371 7.4725159
45A:A:R373 6.26254175
46A:A:R374 7.071676154
47A:A:I375 4.53754159
48A:A:F376 4.767147178
49A:A:R385 8.845405
50A:A:Y391 8.41404
51A:A:L394 3.2675408
52B:B:L7 3.105408
53B:B:L14 1.948508
54B:B:T34 3.36405
55B:B:V40 4.3225223
56B:B:I43 3.6925403
57B:B:M45 3.9725404
58B:B:H54 8.5445149
59B:B:K57 8.78529
60B:B:I58 4.0275409
61B:B:Y59 5.354528
62B:B:W63 8.07407
63B:B:L70 6.62754145
64B:B:V71 5.035118
65B:B:S72 5.0954149
66B:B:Q75 8.005429
67B:B:D76 5.8465289
68B:B:L79 4.2885117
69B:B:I80 8.63754148
70B:B:I81 4.3525117
71B:B:W82 9.137149
72B:B:Y85 10.524194
73B:B:K89 7.09254149
74B:B:I93 5.984117
75B:B:L95 4.124118
76B:B:W99 6.5725829
77B:B:M101 6.1175429
78B:B:Y105 5.568577116
79B:B:N110 9.815494
80B:B:Y111 7.96594
81B:B:V112 5.0625118
82B:B:C114 4.4965118
83B:B:L117 3.636529
84B:B:Y124 4.767147116
85B:B:E138 5.894116
86B:B:L139 6.0325409
87B:B:H142 6.99499
88B:B:Y145 6.13286728
89B:B:F151 5.61509
90B:B:I157 5.175497
91B:B:S160 5.1675486
92B:B:C166 4.235488
93B:B:W169 7.42857798
94B:B:F180 8.116587
95B:B:H183 7.62429789
96B:B:D186 7.285429
97B:B:V187 6.125489
98B:B:F199 7.988589
99B:B:V200 7.34136
100B:B:S201 4.915489
101B:B:D205 6.646589
102B:B:K209 9.494586
103B:B:L210 5.2025405
104B:B:W211 8.53714788
105B:B:Q220 6.0625407
106B:B:F222 9.14138
107B:B:H225 10.37836139
108B:B:D228 7.452529
109B:B:I229 5.88254137
110B:B:I232 5.0065138
111B:B:F234 5.76405
112B:B:F235 7.095246
113B:B:P236 5.674247
114B:B:F241 7.8965136
115B:B:T243 6.29754138
116B:B:S245 6.684139
117B:B:D246 7.215429
118B:B:D247 8.525139
119B:B:R251 9.816676138
120B:B:F253 8.1254136
121B:B:D254 4.852509
122B:B:M262 4.9285204
123B:B:Y264 6.6745205
124B:B:T274 4.3325428
125B:B:S277 3.29405
126B:B:F278 7.084247
127B:B:S279 5.974329
128B:B:S281 5.12409
129B:B:G282 3.8254249
130B:B:R283 6.888577229
131B:B:L284 5.805405
132B:B:L285 5.1975406
133B:B:Y289 7.4954207
134B:B:D290 5.12526
135B:B:C294 4.706525
136B:B:V296 3.455405
137B:B:W297 5.984208
138B:B:R304 6.9565205
139B:B:H311 8.84529
140B:B:R314 10.576528
141B:B:V315 4.494527
142B:B:L318 4.1475426
143B:B:T329 4.928528
144B:B:W332 9.83429729
145B:B:D333 9.15429
146B:B:L336 3.20754147
147B:B:K337 6.714526
148B:B:W339 7.72529
149G:G:Q18 5.475409
150G:G:Y40 11.55754246
151G:G:D48 5.5265329
152G:G:P49 3.4525407
153G:G:L50 4.34754329
154G:G:L51 3.938336226
155G:G:V54 3.9425406
156G:G:N59 5.27754199
157G:G:P60 7.53254199
158G:G:F61 4.697147198
159L:L:L4 4.297120
160L:L:Q6 5.5725120
161L:L:P7 3.43754120
162L:L:I21 4.97254120
163L:L:N29 5.5756120
164L:L:I30 4.1885120
165L:L:N32 8.18410
166L:L:N33 7.026510
167L:L:W37 7.83400
168L:L:Y38 7.6825410
169L:L:Q39 7.052510
170L:L:L41 3.6425410
171L:L:L48 6.3075410
172L:L:L49 6.765410
173L:L:Y51 8.785610
174L:L:Q55 7.6625400
175L:L:L56 6.58410
176L:L:P57 6.38410
177L:L:V60 4.985410
178L:L:R63 8.865410
179L:L:F64 6.16667610
180L:L:L75 6.6975400
181L:L:L80 2.885410
182L:L:Y88 6.7510
183L:L:Y89 7.308510
184L:L:C90 6.754120
185L:L:T91 5.605410
186L:L:W93 5.80167610
187L:L:D94 7.2225120
188L:L:D95 6.616510
189L:L:Q100 12.0925410
190L:L:F102 8.36410
191L:L:T106 5.39754120
192R:R:F37 7.3585371
193R:R:R38 8.19504
194R:R:I44 4.148535
195R:R:I47 3.9075434
196R:R:L50 4.58405
197R:R:P51 4.44375
198R:R:T54 4.914377
199R:R:K58 7.6325415
200R:R:T62 5.1575437
201R:R:L64 4.245436
202R:R:I67 4.364535
203R:R:F72 5.64439
204R:R:R80 10.0686714
205R:R:I81 4.35438
206R:R:I85 5.9575416
207R:R:D86 4.905438
208R:R:H95 9.84215
209R:R:Y98 10.42176212
210R:R:H105 9.1575417
211R:R:E107 8.035416
212R:R:R109 9.494515
213R:R:T111 3.7675435
214R:R:L114 4.605438
215R:R:D118 6.09254395
216R:R:K123 8.85754214
217R:R:L128 4.382539
218R:R:F130 4.94333616
219R:R:L131 3.87333638
220R:R:I133 3.88538
221R:R:F134 6.614515
222R:R:T136 6.38539
223R:R:F141 5.095637
224R:R:P142 4.37409
225R:R:F153 4.53333615
226R:R:F154 5.63667636
227R:R:I155 4.6075415
228R:R:E157 6.532518
229R:R:I158 4.42143737
230R:R:T159 6.42415
231R:R:N161 5.68833638
232R:R:M164 5.332537
233R:R:I167 4.8275437
234R:R:P168 3.812536
235R:R:N170 8.564278
236R:R:F172 5.198538
237R:R:L175 6.32437
238R:R:L180 4.194537
239R:R:L182 5.07536
240R:R:K183 6.9275416
241R:R:Y185 7.67617
242R:R:N187 6.552539
243R:R:F189 7.724538
244R:R:V192 3.09407
245R:R:F197 7.58409
246R:R:N198 9.21754277
247R:R:L202 5.2825408
248R:R:V205 3.686507
249R:R:Y206 6.184516
250R:R:N208 11.2525415
251R:R:F221 9.254419
252R:R:P228 4.16254418
253R:R:L230 5.755414
254R:R:L231 3.24754427
255R:R:D232 10.0975419
256R:R:V233 3.085607
257R:R:V238 3.718507
258R:R:L241 3.6425409
259R:R:L252 3.1154429
260R:R:R255 5.8125404
261R:R:T257 2.806508
262R:R:L260 3.905409
263R:R:F269 3.735257
264R:R:R274 7.0345363
265R:R:D276 7.68254364
266R:R:I281 3.765409
267R:R:F286 4.586258
268R:R:E409 6.93459
269R:R:D410 5.7575459
270R:R:I411 4.57667658
271R:R:M412 5.22558
272R:R:Y414 5.745454
273R:R:L417 5.4225459
274R:R:V421 5.5225459
275R:R:V435 4.0954169
276R:R:I438 6.3185168
277R:R:V448 4.93549
278R:R:P449 4.592548
279R:R:R450 6.094169
280R:R:F451 5.3675449
281R:R:L452 4.37449
282R:R:N455 7.46448
283R:R:L456 5.49167649
284R:R:D460 6.454549
285R:R:M463 5.185469
286R:R:Y466 8.75569
287R:R:L467 3.6075409
288R:R:V473 5.335458
289R:R:D474 7.5025459
290R:R:T477 4.885459
291R:R:Y481 5.70833658
292R:R:H484 6.585406
293R:R:W488 6.02571759
294R:R:T501 8.0425469
295R:R:V502 4.6925469
296R:R:E506 7408
297R:R:L507 5.3875409
298R:R:Y510 5.89447
299R:R:T511 4.825449
300R:R:V514 4.35446
301R:R:E518 5.1475449
302R:R:W520 6.056547
303R:R:Y521 8.1275446
304R:R:I523 4.652509
305R:R:M527 5.236178
306R:R:I533 5.4775445
307R:R:M542 6.19833649
308R:R:W546 6.6975409
309R:R:Y563 8.738569
310R:R:I568 4.7075469
311R:R:C569 4.845459
312R:R:L570 5.5669
313R:R:D573 5.4454238
314R:R:Y582 6.45254239
315R:R:Y601 7.00833649
316R:R:Y605 5.7525439
317R:R:M626 5.435409
318R:R:T632 2.66409
319R:R:Y643 8.065468
320R:R:I648 3.07667666
321R:R:N658 4.5475408
322R:R:V664 3.746559
323R:R:Y667 5.5669
324R:R:N674 7.575449
325R:R:Y678 5.44833649
326R:R:F685 5.993336169
327N:N:Q6 5.514297100
328N:N:L18 3.7585100
329N:N:I20 5.7625100
330N:N:Y27 6.50667610
331N:N:F29 5.89500
332N:N:Y32 9.6075410
333N:N:W33 12.88400
334N:N:N35 5.32510
335N:N:L45 9.8875410
336N:N:W47 10.175410
337N:N:M48 5.334100
338N:N:R50 12.008510
339N:N:D52 8.148510
340N:N:T54 5.54400
341N:N:Y57 9.852510
342N:N:T58 6.864260
343N:N:Y80 6.475400
344N:N:L81 9.2054100
345N:N:W83 8.011676100
346N:N:L86 5.6525100
347N:N:Y94 8.684100
348N:N:Y95 6.766510
349N:N:C96 6.484100
350N:N:R98 12.6925410
351N:N:L99 6.55410
352N:N:E100 7.235610
353N:N:Y103 7.04625810
354N:N:W107 9.57857710
355N:N:S108 3.988510
356N:N:W111 7.126510
357W:W:?1 7.407861460
358H:H:?1 13.174270
359H:H:?2 11.9154400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:H54 B:B:I58 15.38196.63YesYes099
2B:B:I58 B:B:S316 18.9483.1YesNo099
3B:B:S316 B:B:W332 22.07484.94NoYes099
4B:B:R314 B:B:W332 10020.99YesYes289
5B:B:R314 B:B:T274 1006.47YesYes288
6B:B:T274 B:B:V315 1003.17YesYes287
7B:B:H311 B:B:V315 1004.15YesYes297
8B:B:D333 B:B:H311 10010.08YesYes299
9B:B:D312 B:B:D333 1003.99NoYes059
10B:B:D312 R:R:Y444 10011.49NoNo057
11R:R:S442 R:R:Y444 1005.09NoNo087
12R:R:R450 R:R:S442 1003.95YesNo1698
13R:R:N447 R:R:R450 1009.64NoYes089
14R:R:N447 R:R:P449 10013.03NoYes088
15A:A:Y391 R:R:I523 1003.63YesYes049
16A:A:Q384 R:R:I523 68.4014.12NoYes069
17A:A:Q384 A:A:R380 66.62664.67NoNo067
18A:A:N377 A:A:R380 20.43314.82NoNo047
19A:A:F376 A:A:N377 15.9913.62YesNo1784
20A:A:F219 A:A:F376 37.31286.43YesYes1788
21A:A:R380 R:R:M527 45.30654.96NoYes078
22A:A:F376 R:R:M527 31.98184.98YesYes1788
23A:A:H387 R:R:I523 62.18165.3NoYes089
24A:A:H387 A:A:I383 61.29443.98NoNo088
25A:A:I383 R:R:M527 45.30562.92NoYes088
26A:A:H41 R:R:M527 28.42799.19YesYes068
27A:A:F219 A:A:H41 37.31146.79YesYes086
28A:A:I383 A:A:T242 15.10193.04NoNo088
29A:A:H41 A:A:T242 14.21388.21YesNo068
30A:A:V217 R:R:M527 26.65076.09NoYes1758
31A:A:F219 A:A:V217 24.87425.24YesNo1785
32A:A:F212 A:A:F219 92.39110.72NoYes098
33A:A:F212 A:A:M60 71.07034.98NoNo099
34A:A:M221 A:A:M60 49.74275.78YesNo089
35A:A:I375 A:A:M60 14.22362.92YesNo099
36A:A:L388 R:R:I523 1002.85NoYes089
37A:A:L388 A:A:L394 1004.15NoYes088
38A:A:L394 A:A:R385 1003.64YesYes085
39A:A:R385 A:A:Y358 10019.55YesNo054
40A:A:Y358 A:A:Y360 1004.96NoYes048
41A:A:D378 A:A:Y360 10014.94NoYes078
42A:A:D378 A:A:I288 17.566411.2NoNo079
43A:A:I245 A:A:I288 10.54242.94YesNo079
44A:A:D381 A:A:R385 1004.76NoYes085
45A:A:D381 A:A:Y360 10010.34NoYes088
46B:B:W332 B:B:Y59 77.46482.89YesYes298
47A:A:N279 A:A:W281 1005.65NoYes085
48A:A:L282 A:A:N279 10010.98NoNo098
49B:B:M101 B:B:Y59 62.92548.38YesYes298
50B:B:M101 B:B:Y145 61.17285.99YesYes298
51A:A:I276 A:A:L282 1004.28NoNo089
52A:A:D378 A:A:H362 10010.08NoNo079
53A:A:F290 A:A:H362 94.83666.79YesNo1599
54A:A:F290 A:A:T364 84.30873.89YesYes1599
55A:A:N292 A:A:T364 1005.85YesYes099
56A:A:N292 A:A:V247 56.20264.43YesNo097
57A:A:S51 A:A:V247 49.17733.23YesNo097
58A:A:H362 A:A:R374 10012.41NoYes1594
59A:A:R374 A:A:T364 84.2987.76YesYes1549
60A:A:D249 A:A:N50 28.101610.77YesYes1889
61A:A:D249 A:A:K293 42.152215.21YesYes1889
62A:A:K293 A:A:N292 63.22814.2YesYes099
63A:A:K53 A:A:S51 35.12694.59NoYes099
64A:A:D223 A:A:K53 28.101515.21NoNo099
65A:A:N292 A:A:S366 35.12667.45YesNo099
66A:A:S366 A:A:T55 21.07614.8NoNo099
67A:A:M221 A:A:V57 28.43381.52YesNo087
68A:A:R61 A:A:V57 14.21693.92NoNo2987
69A:A:F212 A:A:L63 14.21596.09NoNo099
70A:A:D223 A:A:F208 21.07615.97NoNo095
71R:R:P449 R:R:V448 1003.53YesYes489
72A:A:I276 A:A:L272 1004.28NoNo088
73B:B:S147 B:B:Y145 27.88343.82NoYes098
74A:A:F246 A:A:L272 1006.09NoNo098
75A:A:F246 A:A:F273 1005.36NoYes099
76A:A:F273 A:A:F345 59.1348.57YesYes098
77A:A:F345 A:A:L289 22.94828.53YesNo089
78A:A:L289 A:A:L291 44.135.54NoNo098
79A:A:F363 A:A:L291 42.3654.87YesNo058
80A:A:F363 A:A:Q294 19.41977.03YesYes756
81A:A:C359 A:A:F273 41.48144.19NoYes059
82A:A:C359 A:A:L289 22.94773.17NoNo059
83A:A:L297 A:A:Q294 14.12386.65NoYes786
84A:A:D368 A:A:R374 14.0514.76YesYes1594
85A:A:C365 A:A:D368 10.544.67NoYes089
86A:A:F345 A:A:L270 33.540313.4YesNo086
87A:A:E344 A:A:L270 32.65773.98YesNo056
88A:A:E344 A:A:F340 25.59688.16YesYes757
89A:A:F315 A:A:F340 18.538211.79YesYes067
90A:A:F315 A:A:I308 14.126712.56YesNo067
91A:A:L297 A:A:Y253 12.3593.52NoYes788
92A:A:F273 A:A:W277 22.06546.01YesYes3096
93A:A:S349 A:A:W277 17.6536.18YesYes076
94A:A:C359 A:A:S349 17.6525.16NoYes057
95A:A:W281 B:B:D290 69.98136.7YesYes256
96A:A:L346 A:A:S349 31.77493NoYes047
97A:A:L346 A:A:R342 28.24488.5NoYes744
98A:A:R342 A:A:Y339 19.41747.2YesYes743
99A:A:P321 A:A:Y339 10.5948.34YesYes753
100A:A:F363 A:A:Y339 19.418610.32YesYes753
101A:A:T325 A:A:Y339 14.12356.24NoYes023
102A:A:Y391 R:R:R519 10022.64YesNo049
103R:R:M626 R:R:Y601 1008.38YesYes099
104A:A:L394 R:R:I622 1002.85YesNo088
105B:B:R68 B:B:Y85 10019.55NoYes054
106B:B:Y85 G:G:P60 10012.52YesYes1949
107B:B:M325 G:G:P60 1008.39NoYes059
108B:B:M325 G:G:P49 1005.03NoYes057
109G:G:D48 G:G:P49 1003.22YesYes097
110B:B:S281 G:G:D48 1008.83YesYes099
111B:B:G282 B:B:S281 1003.71YesYes099
112B:B:F278 B:B:G282 1003.01YesYes2479
113B:B:F278 B:B:L285 10010.96YesYes076
114B:B:L285 B:B:Y264 1003.52YesYes065
115B:B:C250 B:B:Y264 1004.03NoYes085
116B:B:C250 B:B:I273 1006.55NoNo086
117B:B:G244 B:B:I273 1005.29NoNo056
118B:B:G244 B:B:S245 1003.71NoYes059
119B:B:H225 B:B:S245 10013.95YesYes1399
120B:B:H225 B:B:T243 1009.58YesYes1398
121B:B:F253 B:B:T243 1006.49YesYes1368
122B:B:F222 B:B:F253 10012.86YesYes1386
123B:B:F222 B:B:Q220 1007.03YesYes087
124B:B:D258 B:B:Q220 1007.83NoYes077
125B:B:D258 B:B:R22 10015.48NoNo076
126B:B:I18 B:B:R22 1007.52NoNo076
127B:B:I18 G:G:A23 94.61773.25NoNo078
128B:B:L14 G:G:A23 86.7331.58YesNo088
129B:B:E10 B:B:L14 31.53942.65NoYes088
130B:B:I229 B:B:S245 1004.64YesYes1379
131B:B:I229 B:B:T243 1006.08YesYes1378
132B:B:E10 G:G:V16 15.76972.85NoNo087
133B:B:F235 B:B:G282 78.83574.52YesYes2469
134B:B:F235 G:G:Y40 70.95695.16YesYes2466
135B:B:N237 G:G:Y40 10015.12NoYes056
136B:B:N237 B:B:N239 94.60186.81NoNo052
137B:B:N239 B:B:R256 86.718812.05NoNo029
138B:B:D254 B:B:R256 63.0713.57YesNo099
139B:B:A257 B:B:D254 85.4044.63NoYes079
140B:B:A257 G:G:V30 68.32321.7NoNo078
141B:B:Q259 G:G:V30 51.24255.73NoNo068
142B:B:C25 B:B:Q259 17.08083.05NoNo036
143B:B:G282 B:B:P236 74.89384.06YesYes2497
144B:B:P236 G:G:Y40 70.95684.17YesYes2476
145B:B:L252 B:B:Y264 39.42735.86NoYes2075
146B:B:L252 B:B:L261 82.77984.15NoNo075
147B:B:D254 B:B:L261 73.58266.79YesNo095
148B:B:A26 B:B:Q259 17.08083.03NoNo036
149B:B:I37 B:B:R283 43.81843.76NoYes029
150B:B:I37 G:G:M38 12.28735.83NoNo024
151B:B:I33 G:G:M38 10.5324.37NoNo034
152B:B:M262 B:B:S31 15.77661.53YesNo041
153B:B:L300 B:B:T34 29.79632.95NoYes065
154B:B:L30 B:B:T34 84.11092.95NoYes055
155B:B:L30 B:B:M262 78.85537.07NoYes054
156B:B:S31 B:B:T29 10.51784.8NoNo013
157B:B:D298 B:B:K301 33.29169.68NoNo095
158B:B:D298 B:B:V40 35.03944.38NoYes2293
159B:B:K301 B:B:T34 29.7854.5NoYes055
160B:B:S279 G:G:D48 1007.36YesYes3299
161G:G:D48 G:G:L50 1004.07YesYes3299
162B:B:M45 G:G:L50 1002.83YesYes049
163B:B:I43 B:B:M45 1004.37YesYes034
164B:B:L284 B:B:V296 13.13965.96YesYes055
165B:B:L286 B:B:S279 1003NoYes079
166B:B:M45 B:B:V296 15.76953.04YesYes045
167B:B:L308 B:B:M45 1005.65NoYes074
168B:B:N340 G:G:N59 11.83088.17NoYes099
169G:G:F61 G:G:N59 15.82933.62YesYes1989
170B:B:H311 B:B:K337 1009.17YesYes296
171B:B:T329 B:B:W339 1003.64YesYes289
172B:B:L286 B:B:V327 1004.47NoNo076
173B:B:V327 B:B:W339 1003.68NoYes069
174B:B:V320 G:G:L50 1002.98NoYes079
175B:B:V320 B:B:V327 1003.21NoNo076
176B:B:L308 B:B:W339 10019.36NoYes079
177B:B:R49 G:G:F61 15.74544.28NoYes1978
178B:B:D66 B:B:R68 1004.76NoNo085
179B:B:D66 B:B:L69 1009.5NoNo085
180B:B:L69 B:B:Y105 1007.03NoYes056
181B:B:V71 B:B:Y105 51.25287.57YesYes1186
182B:B:S147 B:B:S160 27.00073.26NoYes096
183B:B:D323 B:B:M325 15.8074.16NoNo075
184B:B:L79 B:B:V71 39.42582.98YesYes1178
185B:B:I81 B:B:Y105 15.77016.04YesYes1176
186B:B:V112 B:B:Y105 78.85057.57YesYes1186
187B:B:L79 B:B:L95 11.82784.15YesYes1178
188B:B:L95 B:B:V100 15.77054.47YesNo1189
189B:B:A73 B:B:V100 15.77055.09NoNo099
190B:B:V112 B:B:Y124 74.90873.79YesYes1186
191B:B:L95 B:B:Y124 11.82794.69YesYes1186
192B:B:C114 B:B:L79 15.77047.94YesYes1187
193B:B:C114 B:B:V100 15.77053.42YesNo1189
194B:B:C114 B:B:Y124 15.77064.03YesYes1186
195B:B:H91 B:B:I81 11.8285.3NoYes057
196B:B:V135 B:B:Y124 19.71343.79NoYes1146
197B:B:S122 B:B:Y124 15.77075.09NoYes086
198B:B:E138 B:B:S122 11.8284.31YesNo068
199B:B:E138 B:B:V135 11.8284.28YesNo1164
200B:B:E138 B:B:I120 15.77076.83YesNo066
201B:B:G162 B:B:Y145 20.80944.35NoYes298
202B:B:G162 B:B:S161 20.37863.71NoNo099
203B:B:H142 B:B:S161 17.726513.95YesNo099
204B:B:S160 B:B:V187 20.42266.46YesYes869
205B:B:H183 B:B:V187 11.54399.69YesYes899
206B:B:I232 B:B:T243 1003.04YesYes1388
207B:B:I232 B:B:S191 39.42363.1YesNo088
208B:B:F234 B:B:S191 31.53876.61YesNo058
209B:B:I232 B:B:V200 70.96227.68YesYes1386
210B:B:F234 B:B:V200 31.53967.87YesYes056
211B:B:A193 B:B:F234 15.76955.55NoYes045
212B:B:F234 B:B:G238 31.53913.01YesNo057
213B:B:G238 B:B:P194 15.76954.06NoNo074
214B:B:L210 B:B:V200 31.54014.47YesYes056
215B:B:L198 B:B:L210 23.6554.15NoYes035
216B:B:L198 B:B:R197 15.771.21NoNo035
217B:B:F241 B:B:I232 15.76965.02YesYes1368
218B:B:F241 B:B:F253 15.76989.65YesYes1366
219B:B:D247 B:B:S245 35.48054.42YesYes1399
220B:B:H225 B:B:R251 19.712119.18YesYes1398
221B:B:D247 B:B:R251 19.71155.96YesYes1398
222B:B:A240 B:B:D254 17.08083.09NoYes069
223B:B:E260 B:B:R251 23.65526.98NoYes068
224B:B:D254 G:G:A33 17.08086.18YesNo097
225B:B:D258 G:G:R27 15.769715.48NoNo078
226B:B:W297 B:B:Y264 43.363511.58YesYes2085
227B:B:R304 B:B:W297 27.59963YesYes2058
228B:B:S277 B:B:V320 1003.23YesNo057
229B:B:C294 B:B:V315 1005.12YesYes257
230B:B:R256 G:G:I28 15.7692.51NoNo094
231G:G:H44 G:G:Y40 23.656621.78NoYes066
232G:G:N59 G:G:V54 31.54934.43YesYes096
233R:R:L452 R:R:V448 1002.98YesYes499
234R:R:I515 R:R:L452 1005.71NoYes099
235R:R:I515 R:R:L456 1005.71NoYes099
236R:R:D460 R:R:L456 1005.43YesYes499
237R:R:D460 R:R:S671 1007.36YesNo099
238R:R:M463 R:R:S671 1006.13YesNo099
239R:R:M463 R:R:T501 1003.01YesYes699
240R:R:T501 R:R:Y466 10019.97YesYes699
241R:R:I470 R:R:Y466 10010.88NoYes089
242R:R:C569 R:R:I470 1003.27YesNo098
243R:R:C569 R:R:W488 1005.22YesYes599
244R:R:W488 R:R:Y481 1005.79YesYes598
245R:R:A485 R:R:Y481 1006.67NoYes098
246R:R:A485 R:R:I281 1006.5NoYes099
247R:R:H282 R:R:I281 1003.98NoYes099
248R:R:H282 R:R:L263 1002.57NoNo098
249R:R:L260 R:R:L263 1004.15YesNo098
250R:R:L260 R:R:V238 1002.98YesYes097
251R:R:L213 R:R:V238 1002.98NoYes097
252R:R:L213 R:R:V192 1002.98NoYes097
253R:R:I167 R:R:V192 1004.61YesYes077
254R:R:F141 R:R:I167 1003.77YesYes377
255R:R:F141 R:R:P142 1005.78YesYes079
256R:R:I133 R:R:P142 1003.39YesYes089
257R:R:I133 R:R:L131 1002.85YesYes388
258R:R:I106 R:R:L131 1004.28NoYes378
259R:R:I106 R:R:I81 1002.94NoYes378
260R:R:I78 R:R:I81 1004.42NoYes078
261R:R:I78 R:R:L75 1005.71NoNo076
262R:R:L75 R:R:T54 1005.9NoYes067
263R:R:F37 R:R:T54 1003.89YesYes3717
264R:R:F37 R:R:S53 10011.89YesNo015
265H:H:?4 R:R:S53 1004.04NoNo005
266H:H:?4 R:R:Q55 1005.97NoNo3804
267R:R:D36 R:R:Q55 10015.66NoNo034
268R:R:D36 R:R:R38 1003.57NoYes034
269N:N:Y57 R:R:R38 10017.49YesYes004
270N:N:W33 N:N:Y57 1005.79YesYes000
271N:N:R50 N:N:W33 10029.99YesYes000
272N:N:N35 N:N:R50 1003.62YesYes100
273N:N:N35 N:N:W47 1007.91YesYes100
274L:L:S99 N:N:W47 1004.94NoYes000
275L:L:S99 N:N:P62 1003.56NoNo000
276N:N:P62 N:N:S61 1003.56NoNo000
277N:N:S61 N:N:S63 16.19924.89NoNo3500
278R:R:L570 R:R:T501 1002.95YesYes699
279R:R:I568 R:R:L570 1005.71YesYes699
280R:R:I568 R:R:K660 1002.91YesNo099
281R:R:K660 R:R:S567 1003.06NoNo099
282R:R:S567 R:R:Y481 1006.36NoYes598
283R:R:I216 R:R:V238 1003.07NoYes067
284R:R:I216 R:R:V192 1003.07NoYes067
285R:R:F141 R:R:I158 1003.77YesYes377
286R:R:I133 R:R:I158 1002.94YesYes387
287R:R:L144 R:R:P142 99.01593.28NoYes079
288R:R:L131 R:R:L144 98.92015.54YesNo087
289R:R:V233 R:R:V238 1003.21YesYes077
290R:R:L207 R:R:V233 1002.98NoYes077
291R:R:L207 R:R:V205 1002.98NoYes077
292R:R:L182 R:R:V205 1002.98YesYes067
293R:R:L180 R:R:L182 1004.15YesYes376
294R:R:F154 R:R:L180 1004.87YesYes367
295R:R:F154 R:R:L131 1003.65YesYes368
296R:R:L241 R:R:L260 1005.54YesYes099
297R:R:L241 R:R:V233 1002.98YesYes097
298R:R:L260 R:R:T257 1002.95YesYes098
299R:R:T257 R:R:V233 1003.17YesYes087
300R:R:L231 R:R:V233 1004.47YesYes077
301R:R:L231 R:R:V205 1002.98YesYes077
302R:R:L241 R:R:L252 1002.77YesYes099
303R:R:L231 R:R:L252 1002.77YesYes4279
304R:R:L202 R:R:V205 1005.96YesYes087
305R:R:L180 R:R:L202 1004.15YesYes078
306R:R:L241 R:R:P242 1003.28YesNo099
307R:R:F221 R:R:P242 1004.33YesNo099
308R:R:F197 R:R:F221 10017.15YesYes099
309R:R:F197 R:R:L202 99.90023.65YesYes098
310R:R:F172 R:R:F197 99.85475.36YesYes089
311R:R:F172 R:R:L180 99.76943.65YesYes387
312R:R:F154 R:R:L128 1006.09YesYes369
313R:R:I106 R:R:L128 1005.71NoYes379
314N:N:N59 N:N:Y57 10012.79NoYes100
315N:N:N59 N:N:R50 1007.23NoYes100
316N:N:Y103 N:N:Y57 1004.96YesYes100
317N:N:R50 N:N:Y103 1007.2YesYes100
318N:N:L99 N:N:W33 1005.69YesYes000
319N:N:L99 N:N:N35 1005.49YesYes100
320L:L:L97 L:L:S99 1003NoNo000
321L:L:D94 L:L:L97 1009.5YesNo000
322L:L:D94 L:L:L101 48.59374.07YesNo000
323L:L:D94 L:L:N29 10010.77YesYes1200
324L:L:L4 L:L:N29 32.40234.12YesYes1200
325L:L:C23 L:L:L4 16.19613.17NoYes1200
326L:L:L101 L:L:L4 32.40024.15NoYes000
327L:L:I30 L:L:N29 56.6945.66YesYes1200
328L:L:Q100 N:N:N35 1006.6YesYes100
329L:L:F102 L:L:Q100 1008.2YesYes100
330L:L:F102 N:N:L45 10012.18YesYes100
331L:L:Y89 N:N:L45 10017.58YesYes100
332L:L:G105 L:L:Y89 1004.35NoYes000
333L:L:G105 L:L:Q6 70.88216.58NoYes000
334L:L:C90 L:L:Q6 10.13726.1YesYes1200
335N:N:L99 N:N:S108 1006.01YesYes100
336N:N:S108 N:N:W111 1003.71YesYes100
337N:N:V37 N:N:W111 38.46924.9NoYes100
338N:N:L45 N:N:V37 36.44324.47YesNo100
339L:L:C90 L:L:L4 16.21723.17YesYes1200
340L:L:Y38 N:N:S108 1003.82YesYes100
341L:L:L48 L:L:Y38 1009.38YesYes100
342L:L:L48 L:L:P57 1006.57YesYes100
343L:L:L56 L:L:P57 30.40664.93YesYes100
344L:L:I50 L:L:L56 10.15165.71NoYes000
345L:L:G103 L:L:Q6 10.13274.93NoYes000
346L:L:G104 L:L:G105 30.37582.11NoNo000
347L:L:G103 L:L:G104 10.13052.11NoNo000
348L:L:G103 L:L:L4 16.20515.13NoYes000
349L:L:G25 L:L:I30 32.4011.76NoYes000
350L:L:G25 L:L:S24 24.30081.86NoNo000
351L:L:P7 L:L:Q6 20.25343.16YesYes1200
352L:L:Q6 L:L:T106 20.25687.09YesYes1200
353L:L:P57 L:L:V60 83.08977.07YesYes100
354L:L:L49 L:L:V60 20.26832.98YesYes100
355L:L:T106 L:L:V11 10.1273.17YesNo1200
356L:L:F64 L:L:V60 60.83.93YesYes100
357L:L:F64 L:L:I77 22.30667.54YesNo100
358L:L:I77 L:L:L80 18.25092.85NoYes100
359L:L:L80 L:L:P15 32.44631.64YesNo000
360L:L:D84 L:L:F64 20.27873.58NoYes100
361L:L:D84 L:L:L80 18.25114.07NoYes100
362L:L:L48 L:L:Y51 28.35285.86YesYes100
363L:L:Q55 L:L:Y51 48.63616.76YesYes000
364L:L:Q55 R:R:Q235 66.84395.12YesNo004
365L:L:D54 R:R:Q235 60.76732.61NoNo004
366L:L:D54 L:L:G66 54.69063.35NoNo000
367L:L:G66 L:L:S65 48.61391.86NoNo000
368L:L:A76 L:L:S65 42.53721.71NoNo000
369L:L:A76 L:L:T20 36.46053.36NoNo000
370L:L:R18 L:L:T20 18.23031.29NoNo000
371N:N:Y103 R:R:E107 1003.37YesYes106
372R:R:E107 R:R:F134 1008.16YesYes165
373R:R:F134 R:R:T159 1005.19YesYes155
374R:R:T159 R:R:Y185 89.10836.24YesYes157
375L:L:Y51 R:R:Y185 28.36718.94YesYes107
376R:R:N208 R:R:Y185 32.405817.44YesYes157
377L:L:Q55 R:R:N208 24.30137.92YesYes005
378L:L:R18 L:L:R78 12.15354.26NoNo000
379L:L:S74 L:L:T20 12.15353.2NoNo000
380L:L:I30 L:L:V35 16.21156.14YesNo000
381L:L:W93 N:N:Y103 22.26966.75YesYes100
382L:L:D95 L:L:W93 12.15353.35YesYes100
383R:R:D160 R:R:T159 16.215.78NoYes085
384R:R:D160 R:R:N186 12.15176.73NoNo087
385R:R:K209 R:R:N186 10.125913.99NoNo077
386L:L:A73 L:L:V35 10.12475.09NoNo000
387L:L:Q100 N:N:T106 16.203412.76YesNo100
388R:R:R38 R:R:T56 10012.94YesNo045
389R:R:R80 R:R:T56 1003.88YesNo045
390R:R:H105 R:R:R80 10016.93YesYes174
391R:R:F130 R:R:H105 1007.92YesYes167
392R:R:E157 R:R:F130 16.21894.66YesYes186
393R:R:E157 R:R:K183 18.2498.1YesYes186
394N:N:W107 R:R:K183 12.15829.28YesYes106
395N:N:Y57 R:R:R80 1008.23YesYes104
396N:N:P101 R:R:F130 36.44975.78NoYes106
397N:N:E100 N:N:P101 32.40463.14YesNo100
398L:L:L49 L:L:Q39 12.16425.32YesYes100
399L:L:P46 N:N:W111 76.96025.4NoYes100
400N:N:L45 N:N:Q39 10.12445.32YesNo100
401L:L:P46 N:N:Y95 70.88459.74NoYes100
402L:L:Y52 N:N:W107 14.172410.61NoYes100
403L:L:L56 R:R:R255 18.24639.72YesYes004
404R:R:F130 R:R:I155 72.88413.77YesYes165
405R:R:I155 R:R:T181 36.44054.56YesNo157
406R:R:A204 R:R:T181 32.40183.36NoNo157
407R:R:A204 R:R:L230 28.34743.15NoYes154
408R:R:E251 R:R:L230 30.37425.3NoYes054
409R:R:E251 R:R:R274 24.30034.65NoYes053
410R:R:Y185 R:R:Y206 22.28595.96YesYes176
411R:R:L230 R:R:Y206 14.176111.72YesYes146
412R:R:D276 R:R:R255 12.16495.96YesYes044
413L:L:P15 L:L:V110 20.2791.77NoNo000
414L:L:D87 L:L:Y89 20.25135.75NoYes000
415L:L:D87 L:L:R107 10.125717.87NoNo000
416L:L:Y89 N:N:G44 20.25134.35YesNo000
417R:R:T111 R:R:T136 17.30583.14YesYes359
418R:R:L89 R:R:T111 15.44692.95NoYes385
419R:R:D86 R:R:L89 17.34374.07YesNo388
420R:R:F189 R:R:I167 19.5077.54YesYes387
421R:R:F189 R:R:M164 15.49397.46YesYes387
422R:R:L138 R:R:M164 11.78174.24NoYes087
423R:R:E34 R:R:R38 12.17765.82NoYes044
424N:N:T58 R:R:E34 10.1488.47YesNo004
425R:R:L50 R:R:L75 10.11964.15YesNo056
426N:N:D55 R:R:R80 32.397413.1NoYes104
427N:N:D52 R:R:R80 10010.72YesYes104
428N:N:D52 N:N:W33 10010.05YesYes000
429R:R:L128 R:R:V103 11.16342.98YesNo095
430N:N:D52 N:N:T54 42.52577.23YesYes000
431N:N:D55 N:N:T54 28.3435.78NoYes000
432N:N:T54 R:R:K129 60.74086.01YesNo005
433R:R:D151 R:R:K129 10.12556.91NoNo045
434N:N:T30 R:R:K129 40.49133NoNo005
435N:N:R28 N:N:T30 20.24887.76NoNo000
436N:N:R28 R:R:I152 10.12453.76NoNo003
437R:R:F153 R:R:I155 32.39555.02YesYes155
438N:N:D52 N:N:P53 1006.44YesNo000
439N:N:F29 N:N:P53 10010.11YesNo000
440N:N:F29 N:N:Y27 1003.09YesYes000
441R:R:D203 R:R:F153 16.20542.39NoYes065
442R:R:D203 R:R:S229 12.15415.89NoNo065
443R:R:L439 R:R:V435 11.42832.98NoYes089
444R:R:C454 R:R:L439 11.84684.76NoNo088
445R:R:C454 R:R:L436 12.68793.17NoNo085
446R:R:A457 R:R:L436 13.10863.15NoNo095
447R:R:D460 R:R:N432 14.40954.04YesNo099
448R:R:A457 R:R:N432 13.52923.13NoNo099
449R:R:R519 R:R:Y678 1005.14NoYes499
450R:R:N674 R:R:Y678 1005.81YesYes499
451R:R:M626 R:R:Y605 1004.79YesYes099
452N:N:V2 N:N:Y27 12.15175.05NoYes000
453N:N:N110 N:N:R98 10.12644.82NoYes000
454N:N:R98 N:N:Y27 12.19718.52YesYes100
455N:N:L4 N:N:Y27 1003.52NoYes000
456N:N:C96 N:N:L4 1003.17YesNo000
457N:N:C96 N:N:Q6 1007.63YesYes1000
458N:N:G114 N:N:Y95 60.77115.79NoYes000
459N:N:G114 N:N:Q6 58.74614.93NoYes000
460N:N:C96 N:N:W36 1007.84YesNo1000
461N:N:Q6 N:N:T115 1007.09YesNo1000
462N:N:I20 N:N:T115 1009.12YesNo1000
463N:N:L81 N:N:W36 10018.22YesNo1000
464N:N:I20 N:N:L81 78.96497.14YesYes1000
465N:N:S7 N:N:T115 97.19096.4NoNo1000
466N:N:S21 N:N:S7 89.09564.89NoNo000
467N:N:I20 N:N:L18 1004.28YesYes1000
468N:N:L18 N:N:L86 1004.15YesYes1000
469N:N:L86 N:N:V119 1004.47YesNo000
470N:N:P14 N:N:V119 68.83795.3NoNo000
471N:N:L81 N:N:M48 85.0478.48YesYes1000
472N:N:M48 N:N:W83 78.96883.49YesYes1000
473N:N:L86 N:N:W83 10011.39YesYes1000
474N:N:L81 N:N:V68 85.04512.98YesNo1000
475N:N:V68 N:N:W83 78.96927.36NoYes1000
476N:N:F64 N:N:S61 1005.28NoNo3500
477N:N:F64 N:N:R38 10013.9NoNo000
478N:N:R38 N:N:Y94 10019.55NoYes000
479N:N:W83 N:N:Y94 1006.75YesYes1000
480N:N:L18 N:N:V117 14.17414.47YesNo000
481N:N:S21 N:N:Y80 80.9962.54NoYes000
482N:N:K19 N:N:Y80 24.29899.55NoYes000
483N:N:K19 N:N:Q82 16.19935.42NoNo000
484N:N:T78 N:N:Y80 40.49829.99NoYes000
485N:N:F29 N:N:I34 12.15475.02YesNo000
486N:N:K74 N:N:T30 10.12473NoNo000
487N:N:T91 N:N:V119 1001.59NoNo000
488N:N:G92 N:N:T91 1001.82NoNo000
489N:N:G92 N:N:L40 68.83791.71NoNo000
490N:N:L40 N:N:P41 34.41894.93NoNo000
491N:N:I76 N:N:T78 24.29896.08NoNo000
492N:N:D90 N:N:W83 60.75114.52NoYes1000
493N:N:D90 N:N:K87 40.5025.53NoNo000
494N:N:K12 N:N:L86 34.41892.82NoYes000
495B:B:L14 G:G:L19 23.65462.77YesNo089
496B:B:A208 B:B:F241 15.76942.77NoYes066
497B:B:L14 G:G:K20 15.76971.41YesNo086
498L:L:P7 L:L:P8 10.12491.95YesNo000
499L:L:G104 L:L:V3 10.1281.84NoNo000
500B:B:E260 B:B:G224 15.76981.64NoNo066
501G:G:L51 G:G:T52 14.01271.47YesNo064
502N:N:G44 N:N:K43 10.12571.74NoNo000
503N:N:K13 N:N:P14 34.41891.67NoNo000
504N:N:K87 N:N:S89 20.2511.53NoNo000
505N:N:E10 N:N:L18 14.17411.33NoYes000
506G:G:P49 G:G:V54 47.27873.53YesYes076
507G:G:F61 G:G:P60 15.78234.33YesYes1989
508B:B:C294 B:B:L308 1007.94YesNo057
509B:B:H142 B:B:W169 15.07784.23YesYes998
510B:B:L318 B:B:S277 1004.5YesYes065
511B:B:I43 B:B:V40 1003.07YesYes033
512B:B:R283 B:B:V40 80.58117.85YesYes2293
513B:B:I37 B:B:T34 29.793.04NoYes025
514B:B:L300 B:B:R283 31.53479.72NoYes2269
515B:B:L284 G:G:L51 21.0185.54YesYes056
516B:B:L252 B:B:M262 52.54992.83NoYes2074
517B:B:D290 B:B:T274 72.16572.89YesYes268
518A:A:W281 B:B:R314 69.966115.99YesYes258
519B:B:H311 B:B:T329 1006.85YesYes298
520B:B:C294 B:B:T329 1003.38YesYes258
521B:B:K337 B:B:W339 1004.64YesYes269
522B:B:L318 B:B:T329 1004.42YesYes268
523R:R:L456 R:R:Y678 1003.52YesYes499
524R:R:D460 R:R:N674 1008.08YesYes499
525R:R:I622 R:R:Y605 1004.84NoYes089
526R:R:Y601 R:R:Y678 1002.98YesYes499
527R:R:L570 W:W:?1 22.320312.43YesYes690
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:N32 R:R:I85 2.83 1 Yes Yes 0 6 0 1
L:L:N32 R:R:N110 12.26 1 Yes No 0 6 0 1
L:L:N33 R:R:R109 6.03 1 Yes Yes 0 5 0 1
L:L:Y51 R:R:Y185 8.94 1 Yes Yes 0 7 0 1
L:L:D53 R:R:K209 4.15 0 No No 0 7 0 1
L:L:Q55 R:R:N208 7.92 0 Yes Yes 0 5 0 1
L:L:Q55 R:R:K209 10.85 0 Yes No 0 7 0 1
L:L:Q55 R:R:Q235 5.12 0 Yes No 0 4 0 1
L:L:L56 R:R:R255 9.72 1 Yes Yes 0 4 0 1
L:L:S58 R:R:R274 5.27 36 No Yes 0 3 0 1
L:L:S58 R:R:D276 5.89 36 No Yes 0 4 0 1
L:L:G59 R:R:R274 3 0 No Yes 0 3 0 1
L:L:D95 R:R:I85 4.2 1 Yes Yes 0 6 0 1
L:L:D95 R:R:R109 10.72 1 Yes Yes 0 5 0 1
L:L:D98 R:R:K58 5.53 1 No Yes 0 5 0 1
R:R:E34 R:R:R38 5.82 0 No Yes 4 4 1 1
N:N:T58 R:R:E34 8.47 26 Yes No 0 4 0 1
N:N:S56 R:R:E35 11.5 0 No No 0 1 0 1
R:R:D36 R:R:R38 3.57 0 No Yes 3 4 2 1
R:R:R38 R:R:T56 12.94 0 Yes No 4 5 1 2
N:N:Y57 R:R:R38 17.49 1 Yes Yes 0 4 0 1
R:R:K58 R:R:T40 12.01 1 Yes No 5 8 1 2
R:R:R80 R:R:T56 3.88 1 Yes No 4 5 1 2
R:R:I60 R:R:K58 5.82 0 No Yes 4 5 2 1
N:N:Y103 R:R:K58 7.17 1 Yes Yes 0 5 0 1
R:R:E61 R:R:I85 5.47 0 No Yes 5 6 2 1
R:R:R80 R:R:S79 5.27 1 Yes No 4 7 1 1
R:R:S79 R:R:T104 6.4 1 No No 7 5 1 1
N:N:D55 R:R:S79 7.36 1 No No 0 7 0 1
R:R:R80 R:R:Y82 12.35 1 Yes No 4 4 1 1
R:R:H105 R:R:R80 16.93 1 Yes Yes 7 4 1 1
N:N:D52 R:R:R80 10.72 1 Yes Yes 0 4 0 1
N:N:D55 R:R:R80 13.1 1 No Yes 0 4 0 1
N:N:Y57 R:R:R80 8.23 1 Yes Yes 0 4 0 1
R:R:E107 R:R:Y82 8.98 1 Yes No 6 4 1 1
N:N:Y103 R:R:Y82 11.91 1 Yes No 0 4 0 1
R:R:I85 R:R:N110 11.33 1 Yes No 6 6 1 1
R:R:H105 R:R:T104 5.48 1 Yes No 7 5 1 1
N:N:T54 R:R:T104 3.14 0 Yes No 0 5 0 1
R:R:F130 R:R:H105 7.92 1 Yes Yes 6 7 1 1
N:N:D52 R:R:H105 6.3 1 Yes Yes 0 7 0 1
R:R:E107 R:R:R109 11.63 1 Yes Yes 6 5 1 1
R:R:E107 R:R:F134 8.16 1 Yes Yes 6 5 1 2
N:N:Y103 R:R:E107 3.37 1 Yes Yes 0 6 0 1
R:R:F134 R:R:R109 8.55 1 Yes Yes 5 5 2 1
N:N:S104 R:R:R109 10.54 1 No Yes 0 5 0 1
R:R:D151 R:R:K129 6.91 0 No No 4 5 2 1
N:N:T30 R:R:K129 3 0 No No 0 5 0 1
N:N:T54 R:R:K129 6.01 0 Yes No 0 5 0 1
R:R:F130 R:R:G132 3.01 1 Yes No 6 5 1 2
R:R:F130 R:R:I155 3.77 1 Yes Yes 6 5 1 1
R:R:E157 R:R:F130 4.66 1 Yes Yes 8 6 2 1
N:N:P101 R:R:F130 5.78 1 No Yes 0 6 0 1
N:N:G102 R:R:F130 4.52 0 No Yes 0 6 0 1
R:R:F134 R:R:G132 3.01 1 Yes No 5 5 2 2
R:R:E157 R:R:G132 3.27 1 Yes No 8 5 2 2
R:R:E157 R:R:F134 8.16 1 Yes Yes 8 5 2 2
R:R:F134 R:R:T159 5.19 1 Yes Yes 5 5 2 2
N:N:R28 R:R:I152 3.76 0 No No 0 3 0 1
R:R:F153 R:R:I155 5.02 1 Yes Yes 5 5 1 1
R:R:F153 R:R:T179 6.49 1 Yes No 5 5 1 2
R:R:F153 R:R:T181 3.89 1 Yes No 5 7 1 2
N:N:S31 R:R:F153 5.28 0 No Yes 0 5 0 1
N:N:Y32 R:R:F153 4.13 1 Yes Yes 0 5 0 1
R:R:I155 R:R:T181 4.56 1 Yes No 5 7 1 2
N:N:P101 R:R:I155 5.08 1 No Yes 0 5 0 1
R:R:E157 R:R:T159 8.47 1 Yes Yes 8 5 2 2
R:R:E157 R:R:K183 8.1 1 Yes Yes 8 6 2 1
R:R:T159 R:R:Y185 6.24 1 Yes Yes 5 7 2 1
R:R:K183 R:R:Y185 3.58 1 Yes Yes 6 7 1 1
N:N:E100 R:R:K183 6.75 1 Yes Yes 0 6 0 1
N:N:W107 R:R:K183 9.28 1 Yes Yes 0 6 0 1
R:R:Y185 R:R:Y206 5.96 1 Yes Yes 7 6 1 2
R:R:N208 R:R:Y185 17.44 1 Yes Yes 5 7 1 1
N:N:W107 R:R:Y185 3.86 1 Yes Yes 0 7 0 1
R:R:K209 R:R:N186 13.99 0 No No 7 7 1 2
R:R:N208 R:R:Y206 3.49 1 Yes Yes 5 6 1 2
R:R:D232 R:R:Y206 5.75 1 Yes Yes 9 6 2 2
R:R:D232 R:R:N208 16.16 1 Yes Yes 9 5 2 1
R:R:D232 R:R:S234 5.89 1 Yes No 9 9 2 2
R:R:R255 R:R:S234 3.95 0 Yes No 4 9 1 2
R:R:E251 R:R:R274 4.65 0 No Yes 5 3 2 1
R:R:N256 R:R:R255 3.62 0 No Yes 5 4 1 1
R:R:D276 R:R:R255 5.96 36 Yes Yes 4 4 1 1
R:R:D276 R:R:R274 13.1 36 Yes Yes 4 3 1 1
R:R:R274 R:R:V397 9.15 36 Yes No 3 2 1 2
R:R:D276 R:R:T399 5.78 36 Yes No 4 4 1 2
L:L:D54 R:R:Q235 2.61 0 No No 0 4 0 1
R:R:D203 R:R:F153 2.39 0 No Yes 6 5 2 1
L:L:D62 R:R:N256 1.35 0 No No 0 5 0 1
R:R:H32 R:R:R38 1.13 0 No Yes 5 4 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
100.00Single6D35Cholesterol6D35-SMO-Cholesterol
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
100.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
100.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
100.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
100.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
100.00Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
100.00Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
100.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
100.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7XW7K1-707XW7-TSH-K1-70
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
100.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
100.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
100.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
100.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
100.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
100.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
100.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
100.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
100.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
100.00Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
100.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
100.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
100.00Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
100.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
100.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
100.00Single8WVXNorrin8WVX-LGR4-Norrin
100.00Single8WVYNorrin8WVY-LGR4-Norrin
100.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
100.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
100.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
100.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
100.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
100.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
100.00Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
100.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
100.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
100.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
100.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
100.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
50.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
50.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
50.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
25.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
25.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
25.00Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
25.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
25.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
20.00Single5L7DCholesterol5L7D-SMO-Cholesterol
20.00Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
20.00Single8HS2Fab0468HS2-GPR20-Fab046
20.00Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
20.00Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
16.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
16.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
16.67Consensusp2y_offOrthosteric Ligandp2y1_off
14.29Single4XNWMRS25004XNW-P2Y1-MRS2500
14.29Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
14.29Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
14.29Single8JPSCCL78JPS-ACKR1-CCL7
14.29Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
14.29Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
12.50Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.50Single6LI0C176LI0-GPR52-C17
12.50Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
12.50Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Single9B9Y7DY9B9Y-CB1-7DY
11.11Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
11.11Single4BWBNeurotensin4BWB-NTS1-Neurotensin
11.11Single4QINSAG1.54QIN-SMO-SAG1.5
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
11.11Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.11Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
11.11Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.11Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.11Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
11.11Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
11.11Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
11.11Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
11.11Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
11.11Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
11.11Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
11.11Single9BA0A1AKN9BA0-CB1-A1AKN
11.11Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.11Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.11Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
11.11Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.11Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
11.11Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
10.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
10.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
10.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
10.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
10.00Single7VV6C48/807VV6-MRGPRX2-C48/80
10.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
10.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.00Consensusgrh_offOrthosteric Ligandgnrh1_off
10.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
10.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.09Single4QIMANTA XV4QIM-SMO-ANTA XV
9.09Single5T04Neurotensin5T04-NTS1-Neurotensin
9.09Single5TGZAM65385TGZ-CB1-AM6538
9.09Single6D27CAY104716D27-DP2-CAY10471
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
9.09Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
9.09Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.09Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
9.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
9.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.09Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.09Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
9.09Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
9.09Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
9.09Single7YXAONO-54306087YXA-S1P5-ONO-5430608
9.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Single9B9ZA1AKO9B9Z-CB1-A1AKO
9.09Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
9.09Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
9.09Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
9.09Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
8.33Single4JKVTaladegib4JKV-SMO-Taladegib
8.33Single5C1MBU725C1M-μ-BU72
8.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.33Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
8.33Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
8.33Single7C4SS1P7C4S-S1P3-S1P
8.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
8.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
8.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
8.33Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.33Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
8.33Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
7.69Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
7.69Single4BV0Neurotensin4BV0-NTS1-Neurotensin
7.69Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
7.69Single5V56TC1145V56-SMO-TC114
7.69Single5V57TC1145V57-SMO-TC114
7.69Single6OS1TRV0266OS1-AT1-TRV026
7.69Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.69Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
7.69Single7F1TMIP-1a7F1T-CCR5-MIP-1a
7.69Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
7.69Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
7.69Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
7.69Single7R0CAVP7R0C-V2-AVP-Arrestin2
7.69Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
7.69Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
7.69Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
7.69Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
7.69Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Single8E0GBU728E0G-μ-BU72
7.69Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
7.69Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
7.69Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
7.69Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
7.69Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
7.69Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
7.69Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
7.69Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
7.69Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
7.69Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
7.69Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Consensuslpa_onOrthosteric Ligandlpa1_on
7.69Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
7.69Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusneurotensin_onOrthosteric Ligandnts1_on
7.69Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.69Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
7.69Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.69Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.14Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
7.14Single4XEENeurotensin4XEE-NTS1-Neurotensin
7.14Single4XESNeurotensin4XES-NTS1-Neurotensin
7.14Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
7.14Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
7.14Single6OS2TRV0266OS2-AT1-TRV026
7.14Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
7.14Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
7.14Single6YVRNTS8-136YVR-NTS1-NTS8-13
7.14Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
7.14Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
7.14Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
7.14Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
7.14Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
7.14Single8XQJJN2418XQJ-Apelin-JN241
7.14Single8XWACXCL18XWA-CXCR2-CXCL1
7.14Single8XWMCXCL68XWM-CXCR2-CXCL6
7.14Single8XWSCXCL58XWS-CXCR2-CXCL5
7.14Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
7.14Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
7.14Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
7.14Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
7.14Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
7.14Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
7.14Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
7.14Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
7.14Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
7.14Consensuslpa_offOrthosteric Ligandlpa1_off
7.14Consensuslpl_offOrthosteric Ligands1p_off lpa_off
7.14Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
7.14Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
7.14Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
7.14Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
7.14Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
7.14Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
6.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
6.67Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
6.67Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
6.67Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
6.67Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
6.67Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
6.67Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
6.67Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
6.67Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
6.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
6.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
6.67Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
6.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
6.67Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
6.67Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
6.67Single8XVUCXCL28XVU-CXCR2-CXCL2
6.67Single8XWFCXCL38XWF-CXCR2-CXCL3
6.67Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
6.67Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
6.67Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
6.67Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
6.67Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
6.67Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
6.67Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
6.67Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
6.25Single6KNMJN241-96KNM-Apelin-JN241-9
6.25Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
6.25Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
6.25Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
6.25Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
6.25Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
6.25Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
6.25Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
6.25Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
6.25Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
6.25Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8QJ2pN1628QJ2-MC4-pN162-Gs
6.25Single8XQJJN2418XQJ-Apelin-JN241
6.25Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
6.25Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
6.25Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
6.25Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
6.25Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
6.25Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
6.25Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
5.88Single4XT1Fractalkine4XT1-US28-Fractalkine
5.88Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
5.88Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
5.88Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
5.88Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
5.88Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
5.88Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
5.88Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
5.88Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
5.88Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.88Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
5.88Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
5.88Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
5.88Single8XWNCXCL88XWN-CXCR2-CXCL8
5.88Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
5.88Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
5.88Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
5.88Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
5.88Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.88Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
5.88Consensuslpl_onOrthosteric Ligands1p_on lpa_on
5.88Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
5.88Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.88Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
5.56Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
5.56Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
5.56Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
5.56Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
5.56Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
5.56Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
5.56Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
5.56Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
5.56Single7SK5CXCL127SK5-ACKR3-CXCL12
5.56Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
5.56Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
5.56Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
5.56Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.56Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
5.56Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
5.56Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
5.56Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
5.56Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.56Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
5.56Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
5.26Single3OE0CVX153OE0-CXCR4-CVX15
5.26Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
5.26Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.26Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
5.26Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
5.26Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
5.26Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
5.26Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
5.26Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
5.26Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
5.26Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
5.26Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
5.26Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
5.26Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
5.26Consensusangiotensin_onOrthosteric Ligandat1_on
5.26Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.26Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
5.26Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
5.26Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
5.26Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.26Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.26Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
5.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
5.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
5.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
5.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
5.00Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
5.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
5.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
5.00Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
5.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
5.00Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
5.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
5.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
5.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
5.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
5.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
5.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
5.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
5.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
5.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
5.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
5.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
5.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
5.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
4.76Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
4.76Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
4.76Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
4.76Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
4.76Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
4.76Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
4.76Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
4.76Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
4.76Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
4.76Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
4.76Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.76Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
4.76Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.76Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
4.76Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
4.76Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
4.76Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
4.76Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
4.76Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
4.76Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.76Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.76Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
4.76Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
4.76Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
4.76Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
4.76Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
4.76Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
4.76Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
4.55Single4XT3Fractalkine4XT3-US28-Fractalkine
4.55Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
4.55Single6FJ3PTH6FJ3-PTH1-PTH
4.55Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.55Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.55Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
4.55Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
4.55Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.55Single7SK3CXCL127SK3-ACKR3-CXCL12
4.55Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
4.55Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.55Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
4.55Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
4.55Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
4.55Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
4.55Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
4.55Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
4.55Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.55Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
4.55Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.55Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
4.55Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
4.55Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
4.55Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
4.35Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
4.35Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
4.35Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
4.35Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
4.35Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
4.35Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
4.35Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
4.35Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
4.35Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
4.35Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
4.35Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
4.35Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
4.35Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
4.35Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
4.35Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3
4.35Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
4.35Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
4.35Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
4.35Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
4.35Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
4.35Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
4.17Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
4.17Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
4.17Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
4.17Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.17Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
4.17Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
4.17Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
4.17Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
4.17Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
4.17Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
4.17Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
4.17Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
4.17Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
4.17Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
4.17Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
4.17Single8IY6Endothelin-18IY6-ETB-Endothelin-1
4.17Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusbradykinin_onOrthosteric Ligandbk2_on
4.17Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
4.17Consensusendothelin_onOrthosteric Ligandetb_on eta_on
4.17Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
4.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
4.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
4.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
4.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
4.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
4.00Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
4.00Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.00Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.00Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
4.00Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
3.85Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
3.85Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
3.85Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
3.85Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
3.85Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
3.85Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
3.85Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
3.85Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.85Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
3.85Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
3.85Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
3.70Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
3.70Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
3.70Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
3.70Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
3.70Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
3.70Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
3.70Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.57Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
3.57Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
3.57Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
3.57Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
3.57Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
3.57Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
3.57Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
3.57Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.45Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.33Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.33Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.23Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
3.12Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
3.03Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
2.78Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M463 R:R:T501 3.01 6 Yes Yes 9 9 2 2
R:R:M463 R:R:Y667 8.38 6 Yes Yes 9 9 2 1
R:R:T501 R:R:Y466 19.97 6 Yes Yes 9 9 2 2
R:R:L570 R:R:Y466 3.52 6 Yes Yes 9 9 1 2
R:R:L663 R:R:Y466 5.86 6 No Yes 9 9 2 2
R:R:L570 R:R:T501 2.95 6 Yes Yes 9 9 1 2
R:R:T501 R:R:Y667 6.24 6 Yes Yes 9 9 2 1
R:R:E506 R:R:V502 4.28 0 Yes Yes 8 9 2 2
R:R:V502 R:R:Y563 7.57 6 Yes Yes 9 9 2 2
R:R:P571 R:R:V502 3.53 6 No Yes 9 9 1 2
R:R:S505 R:R:Y667 6.36 0 No Yes 9 9 2 1
R:R:E506 R:R:V586 8.56 0 Yes No 8 7 2 1
R:R:P571 R:R:Y563 6.95 6 No Yes 9 9 1 2
R:R:I568 R:R:V566 3.07 6 Yes No 9 9 2 2
R:R:M572 R:R:V566 9.13 6 No No 9 9 1 2
R:R:V566 R:R:V656 3.21 0 No No 9 7 2 1
R:R:I568 R:R:L570 5.71 6 Yes Yes 9 9 2 1
R:R:I568 R:R:L663 7.14 6 Yes No 9 9 2 2
R:R:L570 R:R:M572 4.24 6 Yes No 9 9 1 1
R:R:L570 R:R:L663 4.15 6 Yes No 9 9 1 2
R:R:L570 W:W:?1 12.43 6 Yes Yes 9 0 1 0
R:R:P571 W:W:?1 15.8 6 No Yes 9 0 1 0
R:R:M572 W:W:?1 14.51 6 No Yes 9 0 1 0
R:R:L580 R:R:T574 4.42 6 No No 4 6 2 2
R:R:I648 R:R:T574 4.56 6 Yes No 6 6 1 2
R:R:I648 R:R:L580 2.85 6 Yes No 6 4 1 2
R:R:I583 R:R:L587 2.85 6 No No 7 8 1 2
R:R:I583 R:R:I648 4.42 6 No Yes 7 6 1 1
R:R:I583 W:W:?1 9.16 6 No Yes 7 0 1 0
R:R:V586 W:W:?1 5.74 0 No Yes 7 0 1 0
R:R:A644 R:R:L587 4.73 0 No No 9 8 1 2
R:R:I640 R:R:Y667 4.84 6 No Yes 9 9 1 1
R:R:I640 W:W:?1 7.33 6 No Yes 9 0 1 0
R:R:I654 R:R:Y643 16.92 6 No Yes 9 8 2 2
R:R:L662 R:R:Y643 3.52 6 No Yes 8 8 1 2
R:R:A644 W:W:?1 3.03 0 No Yes 9 0 1 0
R:R:A647 W:W:?1 6.07 0 No Yes 9 0 1 0
R:R:I648 W:W:?1 3.66 6 Yes Yes 6 0 1 0
R:R:P652 W:W:?1 3.16 0 No Yes 9 0 1 0
R:R:I654 R:R:L662 2.85 6 No No 9 8 2 1
R:R:V656 W:W:?1 5.74 0 No Yes 7 0 1 0
R:R:S659 W:W:?1 9.63 0 No Yes 9 0 1 0
R:R:L662 W:W:?1 4.44 6 No Yes 8 0 1 0
R:R:P668 R:R:Y667 4.17 0 No Yes 9 9 2 1
R:R:Y667 W:W:?1 3.01 6 Yes Yes 9 0 1 0
R:R:K651 R:R:P652 1.67 0 No No 4 9 2 1
R:R:I648 R:R:V584 1.54 6 Yes No 6 5 1 2
R:R:I648 R:R:L649 1.43 6 Yes No 6 5 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
75.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
68.75Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
66.67Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
60.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
50.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
43.48Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
42.86Single5WF6UK-4320975WF6-A2A-UK-432097
42.11Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
41.67Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
40.91Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
40.00Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
40.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
39.13Single3QAKUK-4320973QAK-A2A-UK-432097
38.89Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
37.50Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
37.50Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
37.50Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
37.50Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
36.84Single5N2SPSB365N2S-A1-PSB36
36.84Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
36.84Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.84Single8GNEKW-63568GNE-A2A-KW-6356-Na
36.36Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
36.36Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
35.29Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
35.29Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
35.29Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
35.29Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
35.29Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
35.29Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
35.29Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
35.29Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
35.29Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
35.29Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
35.00Single7PX4PSB-21137PX4-A2A-PSB-2113
35.00Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
35.00Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
35.00Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
34.78Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
34.78Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
34.78Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
34.78Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
34.78Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
34.62Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.48Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
34.48Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
34.48Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
33.33Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
33.33Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
33.33Single5IU7Q274563465IU7-A2A-Q27456346-Na
33.33Single5IUBQ274563445IUB-A2A-Q27456344-Na
33.33Single5JTBZM-2413855JTB-A2A-ZM-241385
33.33Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
33.33Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
33.33Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
33.33Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
33.33Single5UVIZM-2413855UVI-A2A-ZM-241385
33.33Single6MH8ZM-2413856MH8-A2A-ZM-241385
33.33Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
33.33Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
33.33Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
33.33Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
33.33Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
33.33Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
33.33Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
33.33Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
33.33Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
33.33Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
33.33Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
33.33Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
33.33Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
33.33Consensusa2_offOrthosteric Liganda2a_off
33.33Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
33.33Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
33.33Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
32.14Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
32.14Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
32.14Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
32.14Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
32.14Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
32.00Single5WF5UK-4320975WF5-A2A-UK-432097
32.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
32.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.00Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
32.00Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
32.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
32.00Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
32.00Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
31.82Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
31.82Single7EZCUKA7EZC-A2A-UKA
31.82Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
31.82Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
31.82Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
31.82Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
31.82Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
31.82Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
31.82Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
31.82Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
31.82Consensuschemerin_onOrthosteric Ligandcml1_on
31.58Single3EMLZM-2413853EML-A2A-ZM-241385
31.58Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
31.58Single5IU8Q274563475IU8-A2A-Q27456347-Na
31.58Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
31.58Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
31.58Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
31.58Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
31.58Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
31.58Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
31.58Single6S0LZM-2413856S0L-A2A-ZM-241385
31.58Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
31.58Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
31.58Single7PYRPSB-21157PYR-A2A-PSB-2115
31.58Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
31.58Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
31.58Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
31.58Consensusa3_onOrthosteric Liganda3a_on
31.25Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
31.25Single6ME5Agomelatine6ME5-MT1-Agomelatine
31.25Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
31.25Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
31.25Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
31.25Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
31.03Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
30.77Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
30.77Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
30.43Single4UG2CGS216804UG2-A2A-CGS21680
30.43Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
30.43Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
30.43Single7XN9L-054,5227XN9-SST2-L-054,522
30.43Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
30.43Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
30.43Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
30.43Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
30.43Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
30.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
30.00Single5N2RPSB-365N2R-A2A-PSB-36-Na
30.00Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
30.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
30.00Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
30.00Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
30.00Single6S0QZM-2413856S0Q-A2A-ZM-241385
30.00Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
30.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
30.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
30.00Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
30.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
30.00Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
30.00Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
30.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
30.00Single8QOTNanobody-E8QOT-μ-Nanobody-E
30.00Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
30.00Consensusa3_on_gpOrthosteric Liganda3a_on_gp
30.00Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
30.00Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
30.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
29.63Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
29.63Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
29.63Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
29.63Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
29.41Single6HLLCP999946HLL-NK1-CP99994
29.41Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
29.41Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
29.41Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
29.41Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
29.41Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
29.17Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
29.17Single7F8XNN90567F8X-CCKA-NN9056
29.17Single8WDTphotoNECA8WDT-A2A-photoNECA
29.17Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
29.17Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
29.17Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
29.17Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
29.17Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
29.17Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
29.17Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
28.57Single2YDVNECA2YDV-A2A-NECA
28.57Single4UHRCGS216804UHR-A2A-CGS21680
28.57Single5G53NECA5G53-A2A-NECA-Gs
28.57Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
28.57Single6J21Aprepitant6J21-NK1-Aprepitant
28.57Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
28.57Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
28.57Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
28.57Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
28.57Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
28.57Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
28.57Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
28.57Consensusa2_onOrthosteric Liganda2b_on
28.57Consensusa2_on_gpOrthosteric Liganda2b_on_gp
28.57Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
28.57Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
28.57Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
28.57Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
28.57Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
28.57Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
28.57Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
28.57Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
28.57Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
28.57Consensusrelaxin_onOrthosteric Ligandrxfp4_on
28.57Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
28.12Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
28.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
28.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
27.78Single3PWHZM-2413853PWH-A2A-ZM-241385
27.78Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
27.78Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
27.78Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
27.78Single6ME9Ramelteon6ME9-MT2-Ramelteon
27.78Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
27.78Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
27.78Single8GNGIstradefylline8GNG-A2A-Istradefylline
27.78Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
27.59Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
27.59Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
27.59Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
27.59Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
27.27Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
27.27Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
27.27Single4RWADIPP-NH24RWA-δ-DIPP-NH2
27.27Single4XEENeurotensin4XEE-NTS1-Neurotensin
27.27Single4XESNeurotensin4XES-NTS1-Neurotensin
27.27Single6MXTSalmeterol6MXT-β2-Salmeterol
27.27Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
27.27Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
27.27Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
27.27Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
27.27Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
27.27Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
27.27Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
27.27Single8XWSCXCL58XWS-CXCR2-CXCL5
27.27Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
27.27Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
27.27Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
27.27Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
27.27Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
27.27Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
27.27Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
26.92Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
26.92Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.92Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
26.92Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
26.67Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
26.67Single8IY6Endothelin-18IY6-ETB-Endothelin-1
26.67Single8PWNTheophylline8PWN-A2A-Theophylline
26.67Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
26.67Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
26.67Consensusbradykinin_onOrthosteric Ligandbk2_on
26.67Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
26.67Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
26.32Single2YDOAdenosine2YDO-A2A-Adenosine
26.32Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
26.32Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
26.32Single6AQFZM-2413856AQF-A2A-ZM-241385
26.32Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
26.32Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
26.32Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
26.32Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
26.32Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
26.32Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
26.32Single7AROLUF58337ARO-A2A-LUF5833-Na
26.32Single7VV6C48/807VV6-MRGPRX2-C48/80
26.32Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
26.32Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
26.32Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
26.32Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.32Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
26.09Single4BUONeurotensin4BUO-NTS1-Neurotensin
26.09Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.09Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
26.09Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
26.09Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.09Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
26.09Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
26.09Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
26.09Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
26.09Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
26.09Consensuscck_onOrthosteric Ligandccka_on cckb_on
26.09Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
25.93Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
25.93Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.93Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
25.93Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.93Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.93Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
25.93Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.93Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
25.93Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
25.93Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
25.93Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.93Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.93Consensusvasop-oxy_onOrthosteric Ligandv2_on
25.93Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
25.81Single5GLHEndothelin-15GLH-ETB-Endothelin-1
25.81Single6IGKEndothelin-36IGK-ETB-Endothelin-3
25.81Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
25.00Single2Y02Carmoterol2Y02-β1-Carmoterol
25.00Single3NY9ICI118-5513NY9-β2-ICI118-551
25.00Single3RFMCaffeine3RFM-A2A-Caffeine
25.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
25.00Single4QIMANTA XV4QIM-SMO-ANTA XV
25.00Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
25.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
25.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
25.00Single5UENDU1725UEN-A1-DU172
25.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
25.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
25.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
25.00Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
25.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
25.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
25.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
25.00Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
25.00Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
25.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
25.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
25.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
25.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
25.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
25.00Single8CU6LJ-45178CU6-A2A-LJ-4517
25.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
25.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
25.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
25.00Single8QJ2pN1628QJ2-MC4-pN162-Gs
25.00Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
25.00Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
25.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
25.00Single8XQJJN2418XQJ-Apelin-JN241
25.00Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
25.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
25.00Single9CHXS-Carazolol9CHX-β2-S-Carazolol
25.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
25.00Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
25.00Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
25.00Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
25.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
25.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
25.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
25.00Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
25.00Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
24.24Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
24.14Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
24.14Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
24.14Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
24.14Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
24.14Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
24.14Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
24.14Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
24.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
24.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
24.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
24.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
24.00Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
24.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
24.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
24.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
24.00Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.81Single4NTJAZD12834NTJ-P2Y12-AZD1283
23.81Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
23.81Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
23.81Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
23.81Single6HLPNetupitant6HLP-NK1-Netupitant
23.81Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
23.81Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
23.81Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
23.81Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
23.81Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
23.81Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.81Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
23.81Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
23.81Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
23.81Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.81Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.81Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
23.81Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
23.81Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
23.81Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
23.53Single3UZAGTPL92363UZA-A2A-GTPL9236
23.53Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
23.53Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
23.53Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
23.53Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
23.53Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
23.53Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
23.53Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
23.53Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
23.53Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
23.33Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
23.33Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
23.08Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
23.08Single6HLOAprepitant6HLO-NK1-Aprepitant
23.08Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
23.08Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
23.08Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
23.08Single8IEBA1LYA8IEB-GPR156-A1LYA
23.08Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
23.08Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
23.08Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
23.08Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
23.08Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
23.08Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
23.08Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
22.73Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
22.73Single4BV0Neurotensin4BV0-NTS1-Neurotensin
22.73Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
22.73Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
22.73Single5V56TC1145V56-SMO-TC114
22.73Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
22.73Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
22.73Single6WGTLSD6WGT-5-HT2A-LSD
22.73Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
22.73Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
22.73Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
22.73Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
22.73Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
22.73Single7R0CAVP7R0C-V2-AVP-Arrestin2
22.73Single7TUYGSK682753A7TUY-GPR183-GSK682753A
22.73Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
22.73Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
22.73Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
22.73Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
22.73Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
22.73Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
22.73Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
22.73Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
22.73Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
22.73Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
22.73Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
22.73Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
22.73Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
22.73Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
22.73Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
22.73Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
22.73Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusneurotensin_onOrthosteric Ligandnts1_on
22.73Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
22.73Consensustachykinin_offOrthosteric Ligandnk1_off
22.58Single6IGLIRL16206IGL-ETB-IRL1620
22.58Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
22.58Consensusendothelin_onOrthosteric Ligandetb_on eta_on
22.58Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
22.58Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
22.22Single3PBLEticlopride3PBL-D3-Eticlopride
22.22Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
22.22Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
22.22Single6PT2KGCHM076PT2-δ-KGCHM07
22.22Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
22.22Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
22.22Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
22.22Single7UL2SR486927UL2-NTS1-SR48692-Na
22.22Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
22.22Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
22.22Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
22.22Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
22.22Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
22.22Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
22.22Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
22.22Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
22.22Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
22.22Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
22.22Consensusangiotensin_onOrthosteric Ligandat1_on
22.22Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
22.22Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
22.22Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
22.22Consensusneurotensin_offOrthosteric Ligandnts1_off
22.22Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
21.88Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
21.74Single4AMIBucindolol4AMI-β1-Bucindolol
21.74Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
21.74Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
21.74Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
21.74Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
21.74Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
21.74Single6OS2TRV0266OS2-AT1-TRV026
21.74Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
21.74Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
21.74Single6YVRNTS8-136YVR-NTS1-NTS8-13
21.74Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
21.74Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
21.74Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
21.74Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
21.74Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8JJLOlodaterol8JJL-β2-Olodaterol
21.74Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
21.74Single8JWY2-1188JWY-A2A-2-118
21.74Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
21.74Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
21.74Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
21.74Single8XWACXCL18XWA-CXCR2-CXCL1
21.74Single8XWMCXCL68XWM-CXCR2-CXCL6
21.74Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
21.74Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
21.74Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
21.74Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
21.74Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
21.74Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
21.43Single6JODAngiotensin II6JOD-AT2-Angiotensin II
21.43Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
21.43Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
21.43Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
21.43Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
21.43Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
21.43Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
21.43Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
21.43Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
21.43Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.43Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
21.43Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
21.21Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
21.21Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
21.21Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
21.21Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
21.21Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
21.05Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
21.05Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
21.05Single6ME2Ramelteon6ME2-MT1-Ramelteon
21.05Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
21.05Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
21.05Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
21.05Single7F8ULintitript7F8U-CCKA-Lintitript
21.05Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
21.05Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
21.05Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
21.05Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
21.05Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
21.05Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
21.05Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
21.05Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
21.05Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
21.05Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
21.05Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
21.05Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
21.05Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
21.05Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
21.05Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
21.05Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
21.05Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
21.05Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
20.83Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
20.83Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
20.83Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
20.83Single6IBLArformoterol6IBL-β1-Arformoterol
20.83Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
20.83Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
20.83Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
20.83Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
20.83Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7UM4AS26747237UM4-5-HT5A-AS2674723
20.83Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
20.83Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
20.83Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
20.83Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
20.83Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
20.83Single8XVUCXCL28XVU-CXCR2-CXCL2
20.83Single8XWFCXCL38XWF-CXCR2-CXCL3
20.83Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
20.83Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
20.83Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
20.83Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
20.83Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
20.83Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
20.83Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
20.83Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
20.83Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
20.69Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
20.69Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
20.69Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
20.69Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
20.69Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
20.69Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
20.69Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
20.69Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
20.69Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
20.00Single3REYXAC3REY-A2A-XAC
20.00Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
20.00Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
20.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
20.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
20.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
20.00Single5ZTYAM102575ZTY-CB2-AM10257
20.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
20.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
20.00Single6KUXRS-799486KUX-α2a-RS-79948
20.00Single6PS0S-Carazolol6PS0-β2-S-Carazolol
20.00Single6PS4ICI118-5516PS4-β2-ICI118-551
20.00Single6PS5S-Propranolol6PS5-β2-S-Propranolol
20.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
20.00Single6PT3DPI-2876PT3-δ-DPI-287
20.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
20.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
20.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
20.00Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
20.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
20.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
20.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
20.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
20.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
20.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
20.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
20.00Single7T32ZM-2413857T32-A2A-ZM-241385
20.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
20.00Single7UL3Famotidine7UL3-H2-Famotidine
20.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
20.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
20.00Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
20.00Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
20.00Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
20.00Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
20.00Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
20.00Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
20.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
20.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
20.00Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
20.00Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
20.00Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
20.00Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
20.00Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
20.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
20.00Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
20.00Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
20.00Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
20.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
20.00Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
20.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
20.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
20.00Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
20.00Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
20.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
20.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
20.00Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
20.00Consensusgrh_offOrthosteric Ligandgnrh1_off
20.00Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.00Consensuskisspeptin_onOrthosteric Ligandkiss1_on
20.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
19.35Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
19.35Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
19.35Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
19.23Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
19.23Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
19.23Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
19.23Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
19.23Single7QA8Peptide7QA8-STE2-Peptide
19.23Single7QA8Peptide7QA8-STE2-Peptide
19.23Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
19.23Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
19.23Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
19.23Single8IEBA1LYA8IEB-GPR156-A1LYA
19.23Single8IEPA1LYA8IEP-GPR156-A1LYA
19.23Single8IEPA1LYA8IEP-GPR156-A1LYA
19.23Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
19.23Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
19.23Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.23Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
19.23Single8XWNCXCL88XWN-CXCR2-CXCL8
19.23Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
19.23Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.23Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
19.23Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
19.23Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
19.23Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
19.23Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
19.05Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
19.05Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
19.05Single3NY8ICI118-5513NY8-β2-ICI118-551
19.05Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
19.05Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
19.05Single4GBRS-Carazolol4GBR-β2-S-Carazolol
19.05Single5T04Neurotensin5T04-NTS1-Neurotensin
19.05Single5UIGCmpd-15UIG-A2A-Cmpd-1
19.05Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
19.05Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
19.05Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
19.05Single6TOTLemborexant6TOT-OX1-Lemborexant
19.05Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
19.05Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
19.05Single7BU7BI1671077BU7-β1-BI167107
19.05Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
19.05Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
19.05Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
19.05Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
19.05Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
19.05Single7UL4Alvimopan7UL4-μ-Alvimopan
19.05Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
19.05Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
19.05Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
19.05Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
19.05Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
19.05Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
19.05Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
19.05Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
19.05Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
19.05Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.05Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
19.05Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
19.05Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
19.05Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
19.05Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
19.05Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
19.05Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
19.05Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
19.05Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
19.05Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
19.05Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
19.05Single8RLNLUF58348RLN-A2A-LUF5834
19.05Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
19.05Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
19.05Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
19.05Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
19.05Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
19.05Single9IYAONO-97105319IYA-GPR55-ONO-9710531
19.05Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
19.05Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
19.05Consensus5ht5_onOrthosteric Ligand5ht5a_on
19.05Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
19.05Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
19.05Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
19.05Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
19.05Consensuscck_offOrthosteric Ligandccka_off
19.05Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
19.05Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
19.05Consensusdopamine_offOrthosteric Ligandd2_off d3_off
19.05Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
19.05Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
19.05Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
19.05Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
19.05Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
18.75Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
18.75Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
18.75Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
18.52Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
18.52Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
18.52Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
18.52Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
18.52Single7XNACYN1548067XNA-SST2-CYN154806
18.52Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
18.52Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
18.52Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
18.52Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
18.52Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
18.52Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
18.52Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
18.52Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
18.18Single2RH1S-Carazolol2RH1-β2-S-Carazolol
18.18Single2YCWS-Carazolol2YCW-β1-S-Carazolol
18.18Single4JKVTaladegib4JKV-SMO-Taladegib
18.18Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
18.18Single5D6LS-Carazolol5D6L-β2-S-Carazolol
18.18Single5JQHS-Carazolol5JQH-β2-S-Carazolol
18.18Single5TVNLSD5TVN-5-HT2B-LSD
18.18Single6D26Fevipiprant6D26-DP2-Fevipiprant
18.18Single6E67BI1671076E67-β2-BI167107-Gs (fused)
18.18Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
18.18Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
18.18Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
18.18Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
18.18Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
18.18Single6TP6Filorexant6TP6-OX1-Filorexant
18.18Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
18.18Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
18.18Single6Z4SSR486926Z4S-NTS1-SR48692
18.18Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
18.18Single7C61Ergotamine7C61-5-HT1B-Ergotamine
18.18Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
18.18Single7SINNPS-21437SIN-CaS-NPS-2143
18.18Single7SINNPS-21437SIN-CaS-NPS-2143
18.18Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
18.18Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
18.18Single7W41PD1762527W41-BB2-PD176252
18.18Single7WC6LSD7WC6-5-HT2A-LSD
18.18Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
18.18Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
18.18Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
18.18Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
18.18Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
18.18Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
18.18Single8S4DCMF-0198S4D-Apelin-CMF-019
18.18Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
18.18Single8TF5Oleic acid8TF5-GPR6-Oleic acid
18.18Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
18.18Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
18.18Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
18.18Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
18.18Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
18.18Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
18.18Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
18.18Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
18.18Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
18.18Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
18.18Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
18.18Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
18.18Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
18.18Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
18.18Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
18.18Consensusamine_offonOrthosteric Ligandamine_off amine_on
18.18Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
18.18Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
18.18Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
18.18Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
18.18Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
18.18Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
18.18Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
18.18Consensusbombesin_offOrthosteric Ligandbb2_off
18.18Consensusbombesin_onOrthosteric Ligandbb2_on
18.18Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
18.18Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
18.18Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
18.18Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
18.18Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
18.18Consensusdp_offOrthosteric Liganddp2_off
18.18Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
18.18Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
18.18Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Consensustrace-amine_onOrthosteric Ligandta1_on
17.86Single3OE0CVX153OE0-CXCR4-CVX15
17.86Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
17.86Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.86Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
17.86Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
17.86Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.86Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.86Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
17.86Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
17.86Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
17.65Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
17.65Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
17.65Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
17.65Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
17.65Consensussensory_onOrthosteric Ligandopsins_on
17.39Single3P0GBI1671073P0G-β2-BI167107
17.39Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
17.39Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
17.39Single5D5AS-Carazolol5D5A-β2-S-Carazolol
17.39Single5D5BS-Carazolol5D5B-β2-S-Carazolol
17.39Single5TZRMK86665TZR-FFA1-MK8666
17.39Single5V54Methiothepin5V54-5-HT1B-Methiothepin
17.39Single5V57TC1145V57-SMO-TC114
17.39Single5XRAAM115425XRA-CB1-AM11542
17.39Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
17.39Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
17.39Single6H7JIsoprenaline6H7J-β1-Isoprenaline
17.39Single6J20Aprepitant6J20-NK1-Aprepitant
17.39Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
17.39Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
17.39Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
17.39Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
17.39Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
17.39Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
17.39Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
17.39Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
17.39Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
17.39Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
17.39Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
17.39Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
17.39Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
17.39Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
17.39Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
17.39Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
17.39Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
17.39Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
17.39Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
17.39Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
17.39Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
17.39Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
17.39Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
17.39Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
17.39Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
17.39Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
17.39Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
17.39Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.39Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
17.39Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
17.39Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
17.39Consensus5ht1_offOrthosteric Ligand5ht1b_off
17.39Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
17.39Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
17.39Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
17.39Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
17.39Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
17.39Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
17.39Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
17.39Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
17.39Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
17.39Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
17.39Consensuslpa_onOrthosteric Ligandlpa1_on
17.39Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
17.39Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
17.39Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.39Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
17.24Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.24Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
17.24Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
17.24Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
17.24Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
17.24Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
17.24Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
17.24Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
17.24Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
17.24Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.24Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.24Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
17.24Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
17.24Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
17.14Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
16.67Single3D4STimolol3D4S-β2-Timolol
16.67Single4LDEBI1671074LDE-β2-BI167107
16.67Single4N4WSANT-14N4W-SMO-SANT-1
16.67Single4PY02MeSATP4PY0-P2Y12-2MeSATP
16.67Single4XNWMRS25004XNW-P2Y1-MRS2500
16.67Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
16.67Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
16.67Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
16.67Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
16.67Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
16.67Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
16.67Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
16.67Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
16.67Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
16.67Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
16.67Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
16.67Single7K15MKD0467K15-BLT1-MKD046-Na
16.67Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
16.67Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
16.67Single7WC5Psilocin7WC5-5-HT2A-Psilocin
16.67Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
16.67Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
16.67Single7YITNalfurafine7YIT-κ-Nalfurafine
16.67Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
16.67Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
16.67Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
16.67Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
16.67Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
16.67Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
16.67Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
16.67Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
16.67Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
16.67Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
16.67Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
16.67Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
16.67Single8JJ8Formoterol8JJ8-β2-Formoterol
16.67Single8JWZAB9288JWZ-A2A-AB928-Na
16.67Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
16.67Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
16.67Single8XQJJN2418XQJ-Apelin-JN241
16.67Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
16.67Single8XYIVUF106618XYI-CXCR3-VUF10661
16.67Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
16.67Single8ZRTET-18ZRT-ETB-ET-1
16.67Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
16.67Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
16.67Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
16.67Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
16.67Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
16.67Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
16.67Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
16.67Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
16.67Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
16.67Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.67Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
16.67Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
16.67Consensusgi_sensoryOrthosteric Ligandgi_opsins
16.67Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
16.67Consensuslpa_offOrthosteric Ligandlpa1_off
16.67Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
16.67Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
16.67Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
16.67Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
16.67Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
16.67Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
16.67Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
16.67Consensusorexin_onOrthosteric Ligandox2_on
16.67Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
16.67Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
16.67Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
16.67Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.13Single6FJ3PTH6FJ3-PTH1-PTH
16.13Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
16.13Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
16.13Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
16.13Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
16.13Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
16.13Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
16.13Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
16.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
16.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
16.00Single6H7LDobutamine6H7L-β1-Dobutamine
16.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
16.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
16.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
16.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
16.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
16.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
16.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
16.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
16.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
16.00Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
16.00Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
16.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
16.00Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.00Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
16.00Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
16.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
16.00Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
16.00Consensusprostanoid_offOrthosteric Ligandep_off dp_off
15.79Single3OE9IT1t3OE9-CXCR4-IT1t
15.79Single4O9RCyclopamine4O9R-SMO-Cyclopamine
15.79Single5L7IVismodegib5L7I-SMO-Vismodegib
15.79Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
15.79Single6TP4ACT-4622066TP4-OX1-ACT-462206
15.79Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
15.79Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
15.79Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
15.79Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
15.79Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
15.79Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
15.79Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
15.79Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
15.79Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
15.79Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
15.79Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
15.79Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
15.79Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
15.79Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
15.79Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
15.79Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
15.79Consensusgq_nucleotideOrthosteric Ligandgq_p2y
15.79Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.79Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
15.79Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
15.62Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
15.62Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
15.62Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
15.62Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
15.38Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
15.38Single6KNMJN241-96KNM-Apelin-JN241-9
15.38Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
15.38Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
15.38Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
15.38Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
15.38Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
15.38Single8IEIA1LYA8IEI-GPR156-A1LYA
15.38Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
15.38Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
15.38Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
15.15Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
15.15Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
15.15Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
15.15Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
15.15Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
15.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
15.00Single4QINSAG1.54QIN-SMO-SAG1.5
15.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
15.00Single5WS3EMPA5WS3-OX2-EMPA
15.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
15.00Single6AKXA4R6AKX-CCR5-A4R
15.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
15.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
15.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
15.00Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
15.00Single6TODEMPA6TOD-OX1-EMPA-Na
15.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
15.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
15.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
15.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
15.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
15.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
15.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
15.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
15.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
15.00Single7XRRLemborexant7XRR-OX2-Lemborexant
15.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
15.00Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
15.00Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
15.00Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
15.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
15.00Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
15.00Single8IWESpermidine8IWE-TA9-Spermidine
15.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
15.00Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
15.00Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
15.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
15.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
15.00Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
15.00Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
15.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
15.00Consensusalpha2_offOrthosteric Ligandalpha2c_off
15.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
15.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
15.00Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
15.00Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
15.00Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
15.00Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
15.00Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
14.81Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
14.81Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
14.81Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
14.81Single8IEIA1LYA8IEI-GPR156-A1LYA
14.81Single8WKYPG-9348WKY-MC4-PG-934
14.81Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
14.81Consensuslpl_onOrthosteric Ligands1p_on lpa_on
14.81Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
14.81Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
14.81Consensussomatostatin_offOrthosteric Ligandsst2_off
14.71Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
14.71Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
14.71Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
14.29Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
14.29Single4MBSMaraviroc4MBS-CCR5-Maraviroc
14.29Single4ZJCSB-6740424ZJC-OX1-SB-674042
14.29Single6A94Zotepine6A94-5-HT2A-Zotepine
14.29Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
14.29Single6TP3Nemorexant6TP3-OX1-Nemorexant
14.29Single6TPGEMPA6TPG-OX2-EMPA
14.29Single6TPKRetosiban6TPK-OT-Retosiban
14.29Single6TPNHTL66416TPN-OX2-HTL6641
14.29Single6V9SGTPL114036V9S-OX1-GTPL11403
14.29Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
14.29Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
14.29Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
14.29Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
14.29Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
14.29Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
14.29Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
14.29Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
14.29Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
14.29Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single7SK5CXCL127SK5-ACKR3-CXCL12
14.29Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
14.29Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
14.29Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
14.29Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
14.29Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
14.29Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
14.29Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
14.29Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
14.29Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
14.29Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
14.29Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
14.29Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
14.29Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
14.29Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
14.29Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
14.29Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
14.29Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
14.29Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
14.29Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
14.29Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
14.29Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
14.29Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
14.29Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
14.29Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
14.29Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
14.29Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
14.29Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
14.29Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
14.29Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
14.29Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9BJKNaloxone9BJK-μ-Naloxone-NAM
14.29Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
14.29Consensusalpha1_onOrthosteric Ligandalpha1a_on
14.29Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
14.29Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
14.29Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
14.29Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
14.29Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
14.29Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.29Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
14.29Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
14.29Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
14.29Consensushca_onOrthosteric Ligandhca2_on
14.29Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
14.29Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
14.29Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
14.29Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
14.29Consensusvasop-oxy_offOrthosteric Ligandot_off
13.79Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
13.79Single6W25SHU91196W25-MC4-SHU9119-Ca
13.79Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
13.79Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
13.79Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
13.79Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
13.79Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
13.79Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
13.79Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
13.79Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
13.79Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
13.79Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
13.79Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
13.79Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.79Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.64Single2Y01Dobutamine2Y01-β1-Dobutamine
13.64Single2Y04Salbutamol2Y04-β1-Salbutamol
13.64Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
13.64Single4QKX35V4QKX-β2-35V
13.64Single5TGZAM65385TGZ-CB1-AM6538
13.64Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
13.64Single6D27CAY104716D27-DP2-CAY10471
13.64Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
13.64Single6H7MSalbutamol6H7M-β1-Salbutamol
13.64Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
13.64Single6PS1Timolol6PS1-β2-Timolol
13.64Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.64Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
13.64Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
13.64Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
13.64Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
13.64Single7WC7Lisuride7WC7-5-HT2A-Lisuride
13.64Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
13.64Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
13.64Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
13.64Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
13.64Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
13.64Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
13.64Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
13.64Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
13.64Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
13.64Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
13.64Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
13.64Single8JJOAlprenolol8JJO-β2-Alprenolol
13.64Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
13.64Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
13.64Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
13.64Single8T1WCVN4248T1W-GPR6-CVN424
13.64Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
13.64Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
13.64Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
13.64Single8X64Desloratadine8X64-H1-Desloratadine
13.64Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
13.64Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
13.64Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
13.64Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
13.64Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
13.64Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
13.64Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
13.64Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
13.64Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
13.64Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
13.64Consensushca_on_gpOrthosteric Ligandhca2_on_gp
13.64Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
13.51Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
13.51Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.33Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.33Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
13.33Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
13.33Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
13.04Single2Y00Dobutamine2Y00-β1-Dobutamine
13.04Single2Y03Isoprenaline2Y03-β1-Isoprenaline
13.04Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
13.04Single5C1MBU725C1M-μ-BU72
13.04Single5WIUNemonapride5WIU-D4-Nemonapride
13.04Single5WIVNemonapride5WIV-D4-Nemonapride-Na
13.04Single5WQCEMPA5WQC-OX2-EMPA
13.04Single5XPRBosentan5XPR-ETB-Bosentan
13.04Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
13.04Single6PS6Timolol6PS6-β2-Timolol
13.04Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
13.04Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
13.04Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
13.04Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.04Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.04Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
13.04Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
13.04Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
13.04Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
13.04Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
13.04Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
13.04Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
13.04Single8JXSPF-61428JXS-D1-PF-6142
13.04Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
13.04Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
13.04Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
13.04Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
13.04Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
13.04Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
13.04Single8ZMFA1L108ZMF-5-HT2C-A1L10
13.04Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
13.04Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
13.04Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
13.04Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
13.04Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.04Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
13.04Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
13.04Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
13.04Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
13.04Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
12.90Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
12.90Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
12.90Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
12.90Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
12.90Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
12.90Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
12.90Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
12.50Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
12.50Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
12.50Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
12.50Single4U15Tiotropium4U15-M3-Tiotropium
12.50Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
12.50Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
12.50Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
12.50Single6E59L-7607356E59-NK1-L-760735
12.50Single6OL9Tiotropium6OL9-M5-Tiotropium
12.50Single6OS1TRV0266OS1-AT1-TRV026
12.50Single7B6WCyclazosin7B6W-α1b-Cyclazosin
12.50Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
12.50Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
12.50Single7F1TMIP-1a7F1T-CCR5-MIP-1a
12.50Single7FEECP559407FEE-CB1-CP55940-ZCZ011
12.50Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
12.50Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
12.50Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
12.50Single7SK3CXCL127SK3-ACKR3-CXCL12
12.50Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
12.50Single8E0GBU728E0G-μ-BU72
12.50Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
12.50Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
12.50Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
12.50Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.50Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
12.50Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
12.50Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
12.50Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
12.50Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
12.50Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
12.50Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
12.50Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8XVLZibotentan8XVL-ETA-Zibotentan
12.50Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
12.50Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
12.50Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
12.50Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
12.50Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.50Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
12.50Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
12.50Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
12.50Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
12.50Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
12.50Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.12Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
12.12Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
12.12Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
12.12Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
12.12Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
12.12Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
12.12Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
12.12Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
12.00Single5CXVTiotropium5CXV-M1-Tiotropium
12.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
12.00Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
12.00Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
12.00Single6KQICP559406KQI-CB1-CP55940-Org27569
12.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
12.00Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
12.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
12.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
12.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
12.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
12.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
12.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
12.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
12.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
12.00Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
12.00Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
12.00Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
12.00Consensusalpha1_offOrthosteric Ligandalpha1a_off
12.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
12.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
12.00Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
12.00Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
12.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
12.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
12.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
12.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
12.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
12.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
12.00Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
12.00Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
11.76Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
11.76Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
11.76Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
11.76Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
11.76Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
11.76Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
11.76Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
11.76Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
11.76Single7WC4Serotonin7WC4-5-HT2A-Serotonin
11.76Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
11.76Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
11.76Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
11.76Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
11.76Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
11.54Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
11.54Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
11.54Single5X93K-87945X93-ETB-K-8794
11.54Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
11.54Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
11.54Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
11.54Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
11.54Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
11.54Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
11.54Consensusendothelin_offOrthosteric Ligandetb_off
11.54Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
11.54Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
11.43Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
11.43Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
11.11Single5EE7MK08935EE7-Glucagon-MK0893
11.11Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.11Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
11.11Single7SK9CCX6627SK9-ACKR3-CCX662
11.11Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
11.11Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
11.11Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
11.11Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
11.11Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
11.11Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
11.11Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
11.11Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
11.11Single8X5YAstemizole8X5Y-H1-Astemizole
11.11Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
11.11Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
11.11Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
11.11Consensusp2y_offOrthosteric Ligandp2y1_off
10.81Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
10.81Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
10.81Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.71Single4XT1Fractalkine4XT1-US28-Fractalkine
10.71Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
10.71Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
10.71Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
10.71Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.71Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
10.71Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
10.71Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
10.71Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
10.53Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
10.53Single3OE6IT1t3OE6-CXCR4-IT1t
10.53Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
10.53Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
10.53Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
10.53Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
10.53Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
10.53Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
10.53Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
10.53Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
10.53Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
10.53Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
10.53Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
10.53Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
10.53Single8JPSCCL78JPS-ACKR1-CCL7
10.53Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
10.53Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
10.53Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
10.53Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
10.53Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
10.53Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
10.53Consensus5ht2_onOrthosteric Ligand5ht2b_on
10.53Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
10.53Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
10.53Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
10.34Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
10.34Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
10.34Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
10.34Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
10.34Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
10.34Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
10.34Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
10.34Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
10.26Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
10.00Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
10.00Single7SRQLSD7SRQ-5-HT2B-LSD
10.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
10.00Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
10.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
10.00Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
10.00Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
10.00Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
10.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
10.00Single8K5BNiacin8K5B-HCA2-Niacin
10.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
10.00Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
10.00Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
10.00Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
10.00Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
10.00Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
10.00Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
10.00Single9B9Y7DY9B9Y-CB1-7DY
10.00Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
9.76Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
9.68Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
9.68Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
9.68Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
9.68Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
9.68Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
9.68Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
9.68Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
9.52Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
9.52Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
9.52Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
9.52Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
9.52Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
9.52Single3ODUIT1t3ODU-CXCR4-IT1t
9.52Single5U09Taranabant5U09-CB1-Taranabant
9.52Single6AKYMaraviroc6AKY-CCR5-Maraviroc
9.52Single6B73MP11046B73-κ-MP1104
9.52Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
9.52Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
9.52Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
9.52Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
9.52Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
9.52Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
9.52Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.52Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.52Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
9.52Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
9.52Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
9.52Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
9.52Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
9.52Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
9.52Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
9.52Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
9.52Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
9.52Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
9.52Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
9.52Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
9.52Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.52Single8Y0HVUF114188Y0H-CXCR3-VUF11418
9.52Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
9.52Single9BA0A1AKN9BA0-CB1-A1AKN
9.52Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
9.52Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
9.52Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
9.52Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
9.52Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
9.52Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
9.52Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
9.52Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
9.38Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
9.38Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
9.38Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
9.38Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
9.09Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
9.09Single3RZECidoxepin3RZE-H1-Cidoxepin
9.09Single4XT3Fractalkine4XT3-US28-Fractalkine
9.09Single6FFIMMPEP6FFI-mGlu5-MMPEP
9.09Single6IQLL7458706IQL-D4-L745870
9.09Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
9.09Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
9.09Single6VI4JDTic6VI4-κ-JDTic
9.09Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
9.09Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
9.09Single6ZINSR486926ZIN-NTS1-SR48692
9.09Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
9.09Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
9.09Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
9.09Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
9.09Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
9.09Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
9.09Single7VODCariprazine7VOD-5-HT2A-Cariprazine
9.09Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
9.09Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
9.09Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
9.09Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
9.09Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
9.09Single8IHKAcifran8IHK-HCA3-Acifran
9.09Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
9.09Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
9.09Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
9.09Single8K5CAcipimox8K5C-HCA2-Acipimox
9.09Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
9.09Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
9.09Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
9.09Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
9.09Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
9.09Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
9.09Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
9.09Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
9.09Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
9.09Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
9.09Consensusopsins_offOrthosteric Ligandrhodopsin_off
9.09Consensussensory_offOrthosteric Ligandopsins_off
8.82Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
8.82Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
8.82Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
8.82Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
8.82Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
8.82Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
8.70Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
8.70Single4DAJTiotropium4DAJ-M3-Tiotropium
8.70Single4MQSIperoxo4MQS-M2-Iperoxo
8.70Single4U14Tiotropium4U14-M3-Tiotropium
8.70Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
8.70Single5DSGTiotropium5DSG-M4-Tiotropium
8.70Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
8.70Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
8.70Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
8.70Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
8.70Single6DRXLisuride6DRX-5-HT2B-Lisuride
8.70Single6FFHFenobam6FFH-mGlu5-Fenobam
8.70Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
8.70Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
8.70Single7F83PF-051904577F83-Ghrelin-PF-05190457
8.70Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
8.70Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
8.70Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
8.70Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
8.70Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
8.70Single7V3ZCP559407V3Z-CB1-CP55940
8.70Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
8.70Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
8.70Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
8.70Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
8.70Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
8.70Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
8.70Single8JXRLSD8JXR-D1-LSD
8.70Single8K5DGSK2560738K5D-HCA2-GSK256073
8.70Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
8.70Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
8.70Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
8.70Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
8.70Single8X63Mepyramine8X63-H1-Mepyramine
8.70Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
8.70Single9B9ZA1AKO9B9Z-CB1-A1AKO
8.70Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
8.70Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
8.70Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
8.70Consensusalpha2_onOrthosteric Ligandalpha2b_on
8.70Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
8.70Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
8.70Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
8.70Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
8.70Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
8.70Consensushistamine_offOrthosteric Ligandh1_off
8.70Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
8.70Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
8.70Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
8.57Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
8.57Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
8.57Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
8.57Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
8.57Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
8.33Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
8.33Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
8.33Single6LUQHaloperidol6LUQ-D2-Haloperidol
8.33Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
8.33Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
8.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
8.33Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
8.33Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
8.33Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
8.33Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
8.33Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
8.33Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
8.33Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
8.33Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
8.33Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
8.33Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
8.33Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
8.33Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
8.33Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.33Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.33Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
8.33Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.11Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
8.11Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
8.00Single4DJHJDTic4DJH-κ-JDTic
8.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
8.00Single5XR8AM8415XR8-CB1-AM841
8.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
8.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
8.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
8.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
8.00Single7P2L4YI7P2L-mGlu5-4YI
8.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
8.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
8.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
8.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
8.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
8.00Single8EA0Iperoxo8EA0-M3-Iperoxo
8.00Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
8.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
8.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
8.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
8.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.00Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
8.00Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
8.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
8.00Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
8.00Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
8.00Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
8.00Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
8.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
8.00Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.00Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
8.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
8.00Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.89Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
7.89Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
7.69Single6A93Risperidone6A93-5-HT2A-Risperidone
7.69Single7DFPSpiperone7DFP-D2-Spiperone
7.69Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
7.69Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
7.69Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
7.69Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
7.69Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
7.69Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.69Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
7.69Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
7.69Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
7.69Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
7.41Single6K1QIRL25006K1Q-ETB-IRL2500
7.41Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
7.41Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
7.41Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
7.41Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
7.41Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
7.41Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
7.41Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
7.41Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single8XVJMacitentan8XVJ-ETA-Macitentan
7.41Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
7.41Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
7.41Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
7.14Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
7.14Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
6.98Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
6.90Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
6.90Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
6.90Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
6.90Single8KIGSHU91198KIG-MC3-SHU9119-Ca
6.90Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
6.90Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
6.82Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
6.67Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
6.45Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
6.25Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
6.25Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
6.25Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
6.06Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
6.06Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
5.88Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
5.56Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.56Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
5.26Single6TQ9SB-4081246TQ9-OX1-SB-408124
5.26Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
5.26Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
5.26Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
5.26Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.26Single9CHUNoradrenaline9CHU-β2-Noradrenaline
5.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
5.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
5.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
5.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.76Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
4.76Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
4.76Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
4.76Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
4.76Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
4.76Single6LI0C176LI0-GPR52-C17
4.76Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
4.76Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
4.76Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
4.76Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
4.76Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
4.76Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
4.76Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
4.76Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
4.76Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
4.76Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
4.55Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
4.55Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.55Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
4.55Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
4.55Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
4.55Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
4.55Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
4.55Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
4.55Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
4.55Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
4.55Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
4.55Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
4.55Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
4.55Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
4.55Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
4.55Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.55Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.55Consensusangiotensin_offOrthosteric Ligandat1_off
4.55Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.55Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
4.55Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
4.55Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
4.55Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.55Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.35Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
4.35Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
4.35Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.35Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
4.35Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
4.35Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
4.35Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
4.35Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
4.17Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
4.17Single4YAYZD-71554YAY-AT1-ZD-7155
4.17Single5DHGC-355DHG-NOP-C-35
4.17Single5DHHSB-6121115DHH-NOP-SB-612111
4.17Single6GPSMK08126GPS-CCR2-MK0812
4.17Single6IIVDaltroban6IIV-TP-Daltroban
4.17Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
4.17Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
4.17Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
4.17Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
4.17Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
4.17Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
4.17Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
4.17Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
4.17Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
4.17Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
4.17Consensusblt_onOrthosteric Ligandblt1_on
4.17Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
4.17Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
4.17Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
4.17Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
4.17Consensusleukotriene_onOrthosteric Ligandblt_on
4.17Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
4.00Single5CGCHTL142425CGC-mGlu5-HTL14242
4.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
4.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
4.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
4.00Single6GPXMK08126GPX-CCR2-MK0812
4.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
4.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
4.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
4.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
4.00Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
4.00Consensusblt_offOrthosteric Ligandblt1_off
4.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
4.00Consensusep_offOrthosteric Ligandep4_off
4.00Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
4.00Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
3.85Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
3.85Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
3.70Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
3.70Single6CM4Risperidone6CM4-D2-Risperidone
3.70Single6IIURamatroban6IIU-TP-Ramatroban
3.70Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
3.70Single6ZG4HTL00099366ZG4-M1-HTL0009936
3.70Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
3.70Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
3.70Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
3.70Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
3.57Single5CGDHTL142425CGD-mGlu5-HTL14242
3.57Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
3.57Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
3.57Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
3.57Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
3.57Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
3.57Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
3.45Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
3.45Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
3.33Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
3.23Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
3.03Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2

PDB Summary
PDB 7XW6
Class A
SubFamily Protein
Type Glycoprotein Hormone
SubType TSH
Species Homo Sapiens
Ligand M22 Fab
Other Ligand(s) ML109
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.78
Date 2022-08-17
D.O.I. 10.1038/s41586-022-05173-3
Net Summary
Imin 2.83
Number of Linked Nodes 1350
Number of Links 1784
Number of Hubs 359
Number of Links mediated by Hubs 1221
Number of Communities 44
Number of Nodes involved in Communities 478
Number of Links involved in Communities 734
Path Summary
Number Of Nodes in MetaPath 528
Number Of Links MetaPath 527
Number of Shortest Paths 327741007
Length Of Smallest Path 3
Average Path Length 128
Length of Longest Path 91
Minimum Path Strength 1.17
Average Path Strength 8.05358
Maximum Path Strength 20.995
Minimum Path Correlation 0.71
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.69492
Average % Of Corr. Nodes 128
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 128
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • molecular transducer activity   • signaling receptor activity   • protein-hormone receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • thyroid-stimulating hormone receptor activity   • peptide receptor activity   • G protein-coupled peptide receptor activity   • response to peptide hormone   • cellular response to peptide hormone stimulus   • cellular response to thyrotropin-releasing hormone   • response to thyrotropin-releasing hormone   • hormone-mediated signaling pathway   • response to glycoprotein   • cellular response to glycoprotein   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • positive regulation of biological process   • positive regulation of cellular process   • homeostatic process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • cell surface receptor signaling pathway   • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger   • thyroid-stimulating hormone signaling pathway   • cell surface   • basal part of cell   • basal plasma membrane   • plasma membrane region   • basolateral plasma membrane   • receptor complex
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • L domain-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • L domain-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeHOI
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeHOI
Name~{N}-[4-[[2-methoxy-5-[(2~{S})-5-oxidanyl-4-oxidanylidene-3-(phenylmethyl)-1,2-dihydroquinazolin-2-yl]phenyl]methoxy]phenyl]ethanamide
Synonyms
Identifier
FormulaC31 H29 N3 O5
Molecular Weight523.579
SMILES
PubChem118685720
Formal Charge0
Total Atoms68
Total Chiral Atoms1
Total Bonds72
Total Aromatic Bonds24

CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3 H:H:?4
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetyl-D-glucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7XW6_Chain_A
QRNEEKAQR EANKKIEKQ LQKDKQVYR ATHRLLLLG ADNSGKSTI 
VKQMRILHS GIFETKFQV DKVNFHMFD VGAQRDERR KWIQCFNDV 
TAIIFVVDS SDYNRLQEA LNLFKSIWN NRWLRTISV ILFLNKQDL 
LAEKVLAGK SKIEDYFPE FARYTTPED ATPEPGEDP RVTRAKYFI 
RDEFLRIST ASGDGRHYC YPHFTCSVD TENARRIFN DCRDIIQRM 
HLRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7XW6_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7XW6_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP16473
Sequence
>7XW6_Chain_R
PCECHQEED FRVTCKDIQ RIPSLPPST QTLKLIETH LRTIPSHAF 
SNLPNISRI YVSIDVTLQ QLESHSFYN LSKVTHIEI RNTRNLTYI 
DPDALKELP LLKFLGIFN TGLKMFPDL TKVYSTDIF FILEITDNP 
YMTSIPVNA FQGLCNETL TLKLYNNGF TSVQGYAFN GTKLDAVYL 
NKNKYLTVI DKDAFGGVY SGPSLLDVS QTSVTALPS KGLEHLKEL 
IARNTWTLK KLPLSLSFL HLTRADLSY PIHCCAFKN QKEDMVCTP 
KSDEFNPCE DIMGYKFLR IVVWFVSLL ALLGNVFVL LILLTSHYK 
LNVPRFLMC NLAFADFCM GMYLLLIAS VDLYTHSEY YNHAIDWQT 
GPGCNTAGF FTVFASELS VYTLTVITL ERWYAITFA MRLDRKIRL 
RHACAIMVG GWVCCFLLA LLPLVGISS YAKVSICLP MDTETPLAL 
AYIVFVLTL NIVAFVIVC CCYVKIYIT VRNPDKDTK IAKRMAVLI 
FTDFICMAP ISFYALSAI LNKPLITVS NSKILLVLF YPLNSCANP 
FLYAIFTKA FQRDVFILL SKFG


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XW5AProteinGlycoprotein HormoneTSHHomo sapiensTSHML109Gs/β1/γ22.962022-08-2410.1038/s41586-022-05173-3
7XW5 (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensTSHML1092.962022-08-2410.1038/s41586-022-05173-3
7XW7AProteinGlycoprotein HormoneTSHHomo sapiensK1-70--5.52022-08-1710.1038/s41586-022-05173-3
7XW6AProteinGlycoprotein HormoneTSHHomo sapiensM22 FabML109Gs/β1/γ22.782022-08-1710.1038/s41586-022-05173-3
7XW6 (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensM22 FabML1092.782022-08-1710.1038/s41586-022-05173-3
7T9MAProteinGlycoprotein HormoneTSHHomo sapiens-CS-17 Antibody-3.12022-08-1010.1038/s41586-022-05159-1
7UTZAProteinGlycoprotein HormoneTSHHomo sapiensTR1402PubChem 644078Gs/β1/γ22.42022-08-0310.1038/s41586-022-05159-1
7UTZ (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensTR1402PubChem 6440782.42022-08-0310.1038/s41586-022-05159-1
7T9NAProteinGlycoprotein HormoneTSHHomo sapiensM22 FabPubChem 644078Gs/β1/γ22.92022-08-0310.1038/s41586-022-05159-1
7T9N (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensM22 FabPubChem 6440782.92022-08-0310.1038/s41586-022-05159-1
7T9IAProteinGlycoprotein HormoneTSHHomo sapiensTSH-Gs/β1/γ22.92022-08-0310.1038/s41586-022-05159-1
7T9I (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensTSH-2.92022-08-0310.1038/s41586-022-05159-1




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7XW6.zip



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