psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	H:H:?1	L:L:I49	5.12	No	No	1	0	5
2	H:H:?1	L:L:N102	25.87	No	Yes	1	0	9
3	H:H:?2	L:L:K68	3.8	No	No	11	0	6
4	H:H:?2	L:L:N76	28.34	No	No	11	0	9
5	H:H:?2	N:N:Y79	14.73	No	No	11	0	8
6	H:H:?3	N:N:N43	30.8	No	No	0	0	8
7	H:H:?4	R:R:Y98	4.21	No	Yes	9	0	2
8	H:H:?4	R:R:N99	33.27	No	No	9	0	5
9	H:H:?5	R:R:P76	2.95	Yes	No	17	0	5
10	H:H:?5	R:R:N77	27.11	Yes	No	17	0	8
11	H:H:?6	R:R:N170	11.09	No	Yes	12	0	8
12	H:H:?6	R:R:Q173	10.75	No	Yes	12	0	2
13	H:H:?6	R:R:N198	24.64	No	Yes	12	0	7
14	H:H:?7	R:R:T150	5.29	No	Yes	13	0	3
15	H:H:?7	R:R:N177	29.57	No	No	13	0	5
16	H:H:?7	R:R:E178	17.84	No	Yes	13	0	5
17	L:L:C31	L:L:C55	7.28	No	No	0	9	9
18	L:L:C31	N:N:Y50	6.72	No	No	0	9	6
19	L:L:P32	R:R:L378	6.57	No	No	0	5	4
20	L:L:C34	L:L:C56	3.64	No	No	14	9	9
21	L:L:C34	L:L:C84	7.28	No	No	0	9	9
22	L:L:C108	L:L:C34	3.64	No	No	14	9	9
23	L:L:L36	L:L:L50	5.54	No	No	0	9	5
24	L:L:C106	L:L:L36	4.76	No	No	0	9	9
25	L:L:M53	L:L:R37	4.96	Yes	No	1	4	4
26	L:L:R37	R:R:L378	4.86	No	No	1	4	4
27	L:L:R38	L:L:S43	7.91	No	No	0	4	8
28	L:L:P48	L:L:R38	5.76	No	No	0	6	4
29	L:L:F41	L:L:N39	3.62	Yes	No	1	1	8
30	L:L:N39	L:L:Q51	13.2	No	No	1	8	9
31	L:L:N39	N:N:N57	5.45	No	Yes	1	8	7
32	L:L:R40	R:R:D382	3.57	No	No	0	1	4
33	L:L:R40	R:R:D386	5.96	No	No	0	1	5
34	L:L:F41	L:L:F42	4.29	Yes	Yes	1	1	6
35	L:L:F41	R:R:M300	12.44	Yes	Yes	0	1	3
36	L:L:F41	R:R:Y385	11.35	Yes	Yes	1	1	4
37	L:L:F41	R:R:D386	4.78	Yes	No	1	1	5
38	L:L:F42	L:L:V94	5.24	Yes	No	1	6	3
39	L:L:F42	L:L:V100	10.49	Yes	Yes	1	6	5
40	L:L:F42	N:N:N57	6.04	Yes	Yes	1	6	7
41	L:L:F42	R:R:L296	4.87	Yes	No	0	6	4
42	L:L:P45	L:L:R44	8.65	No	No	0	3	3
43	L:L:M95	L:L:R44	3.72	No	No	0	3	3
44	L:L:I49	L:L:N102	7.08	No	Yes	1	5	9
45	L:L:M53	L:L:Q51	6.8	Yes	No	1	4	9
46	L:L:Q51	N:N:N57	6.6	No	Yes	1	9	7
47	L:L:C52	L:L:H103	4.42	No	Yes	1	9	9
48	L:L:C106	L:L:C52	7.28	No	No	0	9	9
49	L:L:C52	N:N:D55	7.78	No	No	1	9	7
50	L:L:M53	N:N:R54	7.44	Yes	Yes	0	4	5
51	L:L:M53	R:R:L378	4.24	Yes	No	1	4	4
52	L:L:C56	L:L:T82	5.07	No	No	14	9	8
53	L:L:C108	L:L:C56	7.28	No	No	14	9	9
54	L:L:F57	L:L:R59	5.34	No	No	0	7	8
55	L:L:F57	N:N:G49	3.01	No	No	0	7	9
56	L:L:F57	N:N:Y50	6.19	No	No	0	7	6
57	L:L:S58	L:L:S81	3.26	No	No	0	9	9
58	L:L:R59	L:L:Y61	8.23	No	Yes	0	8	8
59	L:L:A60	L:L:S79	3.42	No	No	0	9	9
60	L:L:A60	N:N:T73	3.36	No	No	0	9	8
61	L:L:T78	L:L:Y61	9.99	No	Yes	0	9	8
62	L:L:E80	L:L:Y61	6.73	No	Yes	0	9	8
63	L:L:Y61	N:N:Y27	6.95	Yes	Yes	4	8	6
64	L:L:Y61	N:N:I46	4.84	Yes	Yes	4	8	9
65	L:L:P62	N:N:M29	3.35	No	Yes	0	9	7
66	L:L:P62	N:N:I46	3.39	No	Yes	0	9	9
67	L:L:P62	N:N:P98	7.79	No	No	0	9	9
68	L:L:P64	L:L:T63	3.5	No	Yes	1	9	9
69	L:L:S67	L:L:T63	3.2	Yes	Yes	1	7	9
70	L:L:M71	L:L:T63	3.01	Yes	Yes	1	9	9
71	L:L:T63	L:L:T78	7.85	Yes	No	0	9	9
72	L:L:P64	L:L:S67	3.56	No	Yes	1	9	7
73	L:L:P64	N:N:T122	5.25	No	Yes	1	9	4
74	L:L:L65	N:N:R33	6.07	No	No	0	6	6
75	L:L:L65	N:N:F95	6.09	No	No	0	6	7
76	L:L:R66	N:N:E32	8.14	No	Yes	0	6	9
77	L:L:R66	N:N:Y124	8.23	No	No	0	6	4
78	L:L:S67	N:N:T122	3.2	Yes	Yes	1	7	4
79	L:L:S67	R:R:I85	4.64	Yes	Yes	0	7	6
80	L:L:K68	L:L:Q74	9.49	No	No	0	6	7
81	L:L:K68	L:L:N76	9.79	No	No	11	6	9
82	L:L:T70	R:R:I85	6.08	No	Yes	0	9	6
83	L:L:T70	R:R:V87	3.17	No	No	0	9	4
84	L:L:M71	N:N:D114	5.54	Yes	Yes	1	9	9
85	L:L:M71	R:R:N110	8.41	Yes	Yes	1	9	6
86	L:L:M71	R:R:N135	4.21	Yes	Yes	1	9	8
87	L:L:L72	R:R:R112	6.07	No	No	0	3	6
88	L:L:L72	R:R:N135	4.12	No	Yes	0	3	8
89	L:L:L72	R:R:P162	6.57	No	No	0	3	7
90	L:L:K75	L:L:V73	3.04	No	No	1	9	7
91	L:L:V73	R:R:N135	5.91	No	Yes	1	7	8
92	L:L:V73	R:R:D160	4.38	No	Yes	1	7	8
93	L:L:K75	N:N:D114	4.15	No	Yes	1	9	9
94	L:L:K75	R:R:D160	8.3	No	Yes	1	9	8
95	L:L:N76	N:N:Y79	6.98	No	No	11	9	8
96	L:L:V77	N:N:Y74	6.31	No	Yes	0	9	8
97	L:L:V77	N:N:Y112	3.79	No	Yes	18	9	5
98	L:L:V77	N:N:S113	6.46	No	No	18	9	7
99	L:L:T78	N:N:I116	3.04	No	Yes	0	9	7
100	L:L:S79	N:N:C108	3.44	No	No	0	9	9
101	L:L:E80	N:N:I116	8.2	No	Yes	0	9	7
102	L:L:C111	L:L:S81	5.16	Yes	No	0	9	9
103	L:L:S81	N:N:V71	6.46	No	No	0	9	6
104	L:L:C108	L:L:T82	5.07	No	No	14	9	8
105	L:L:T82	N:N:H117	5.48	No	No	0	8	5
106	L:L:C111	L:L:C83	7.28	Yes	No	1	9	9
107	L:L:C83	N:N:T53	6.76	No	No	1	9	9
108	L:L:C83	N:N:Q69	10.68	No	Yes	1	9	9
109	L:L:A86	L:L:H103	8.78	No	Yes	0	9	9
110	L:L:H107	L:L:K87	7.86	No	No	0	8	5
111	L:L:S88	L:L:T104	6.4	No	No	0	4	9
112	L:L:R91	L:L:Y89	5.14	No	No	0	4	4
113	L:L:E101	L:L:Y89	20.2	Yes	No	0	5	4
114	L:L:N90	L:L:T104	4.39	No	No	0	4	9
115	L:L:R91	R:R:I152	3.76	No	No	0	4	3
116	L:L:N102	L:L:V92	4.43	Yes	No	0	9	4
117	L:L:K99	L:L:T93	6.01	No	No	0	3	3
118	L:L:V100	L:L:V94	4.81	Yes	No	1	5	3
119	L:L:F98	N:N:F61	4.29	No	Yes	0	3	3
120	L:L:V100	N:N:N57	2.96	Yes	Yes	1	5	7
121	L:L:E101	L:L:H103	7.39	Yes	Yes	1	5	9
122	L:L:E101	N:N:K59	4.05	Yes	Yes	1	5	5
123	L:L:E101	R:R:F153	4.66	Yes	No	1	5	5
124	L:L:H103	N:N:D55	11.35	Yes	No	1	9	7
125	L:L:H103	N:N:N57	8.93	Yes	Yes	1	9	7
126	L:L:H107	L:L:S109	6.97	No	No	0	8	8
127	L:L:S109	L:L:T110	3.2	No	No	0	8	9
128	L:L:T110	N:N:H117	17.8	No	No	0	9	5
129	L:L:C111	L:L:H114	8.85	Yes	Yes	1	9	8
130	L:L:C111	N:N:Q69	3.05	Yes	Yes	1	9	9
131	L:L:Y112	L:L:Y113	5.96	Yes	Yes	1	5	4
132	L:L:Y112	R:R:H105	8.71	Yes	Yes	1	5	7
133	L:L:Y112	R:R:F130	10.32	Yes	Yes	1	5	6
134	L:L:Y112	R:R:I155	3.63	Yes	No	1	5	5
135	L:L:Y113	N:N:K59	8.36	Yes	Yes	1	4	5
136	L:L:Y113	N:N:L67	8.21	Yes	No	1	4	4
137	L:L:Y113	N:N:Q69	11.27	Yes	Yes	1	4	9
138	L:L:H114	L:L:K115	11.79	Yes	Yes	1	8	9
139	L:L:H114	N:N:V71	6.92	Yes	No	0	8	6
140	L:L:H114	N:N:C115	2.95	Yes	No	1	8	9
141	L:L:K115	N:N:T110	4.5	Yes	No	1	9	7
142	L:L:K115	N:N:C115	9.7	Yes	No	1	9	9
143	L:L:K115	R:R:R109	3.71	Yes	Yes	1	9	5
144	L:L:K115	R:R:F134	4.96	Yes	Yes	1	9	5
145	L:L:K115	R:R:E157	9.45	Yes	Yes	1	9	8
146	L:L:K115	R:R:Y185	4.78	Yes	Yes	1	9	7
147	L:L:S116	N:N:K107	6.12	No	No	0	9	4
148	N:N:C22	N:N:C72	7.28	Yes	No	5	9	9
149	N:N:I23	N:N:P24	3.39	No	No	0	4	7
150	N:N:C103	N:N:P24	5.65	No	No	0	9	7
151	N:N:I46	N:N:T25	3.04	Yes	No	0	9	5
152	N:N:A48	N:N:T25	3.36	No	No	0	8	5
153	N:N:E26	N:N:N43	10.52	No	No	0	9	8
154	N:N:M29	N:N:Y27	7.18	Yes	Yes	4	7	6
155	N:N:I46	N:N:Y27	15.71	Yes	Yes	4	9	6
156	N:N:N123	N:N:Y27	11.63	No	Yes	0	5	6
157	N:N:T28	N:N:T41	3.14	No	No	0	8	7
158	N:N:N43	N:N:T28	4.39	No	No	0	8	8
159	N:N:I31	N:N:M29	4.37	No	Yes	0	7	7
160	N:N:M29	N:N:T44	3.01	Yes	No	4	7	9
161	N:N:M29	N:N:Y97	4.79	Yes	Yes	4	7	6
162	N:N:C39	N:N:H30	2.95	No	Yes	15	9	6
163	N:N:H30	N:N:T41	5.48	Yes	No	0	6	7
164	N:N:H30	N:N:N123	5.1	Yes	No	0	6	5
165	N:N:C125	N:N:H30	7.37	No	Yes	15	9	6
166	N:N:I31	N:N:I84	4.42	No	No	0	7	6
167	N:N:F95	N:N:I31	5.02	No	No	0	7	7
168	N:N:C39	N:N:E32	3.04	No	Yes	15	9	9
169	N:N:C125	N:N:E32	7.6	No	Yes	15	9	9
170	N:N:E32	N:N:T126	5.64	Yes	No	0	9	6
171	N:N:E32	N:N:K127	18.9	Yes	No	0	9	5
172	N:N:E35	N:N:R33	6.98	No	No	0	6	6
173	N:N:C36	N:N:R33	5.57	No	No	0	9	6
174	N:N:E35	N:N:H90	6.15	No	No	19	6	5
175	N:N:E35	N:N:V91	11.41	No	No	19	6	7
176	N:N:C36	N:N:C87	7.28	No	No	0	9	9
177	N:N:G86	N:N:Y38	4.35	No	No	0	7	4
178	N:N:C125	N:N:C39	7.28	No	No	15	9	9
179	N:N:L40	N:N:V82	4.47	No	No	0	7	5
180	N:N:L40	N:N:P85	4.93	No	No	0	7	8
181	N:N:I42	N:N:V82	3.07	No	No	0	7	5
182	N:N:I42	N:N:Y97	3.63	No	Yes	0	7	6
183	N:N:T44	N:N:Y97	9.99	No	Yes	4	9	6
184	N:N:T44	N:N:V99	4.76	No	No	4	9	8
185	N:N:C47	N:N:Y74	5.38	Yes	Yes	0	9	8
186	N:N:C103	N:N:C47	7.28	No	Yes	5	9	9
187	N:N:C105	N:N:C51	7.28	No	No	5	9	9
188	N:N:M52	R:R:T377	3.01	No	No	0	1	3
189	N:N:M52	R:R:F381	11.2	No	No	0	1	4
190	N:N:Q69	N:N:T53	5.67	Yes	No	1	9	9
191	N:N:R54	R:R:F381	20.31	Yes	No	0	5	4
192	N:N:R54	R:R:D382	3.57	Yes	No	0	5	4
193	N:N:R54	R:R:Y385	11.32	Yes	Yes	0	5	4
194	N:N:I56	R:R:Y385	8.46	No	Yes	0	5	4
195	N:N:K59	N:N:L67	4.23	Yes	No	1	5	4
196	N:N:K59	R:R:F153	16.13	Yes	No	1	5	5
197	N:N:L60	R:R:F153	3.65	No	No	0	3	5
198	N:N:F61	R:R:L296	10.96	Yes	No	0	3	4
199	N:N:F61	R:R:E297	5.83	Yes	Yes	0	3	5
200	N:N:L62	N:N:P63	4.93	No	Yes	1	3	4
201	N:N:L62	R:R:E297	3.98	No	Yes	1	3	5
202	N:N:L62	R:R:M300	5.65	No	Yes	0	3	3
203	N:N:P63	N:N:Y65	6.95	Yes	Yes	1	4	4
204	N:N:A66	N:N:P63	3.74	No	Yes	0	4	4
205	N:N:P63	R:R:E297	4.72	Yes	Yes	1	4	5
206	N:N:K64	R:R:D203	12.44	No	Yes	0	5	6
207	N:N:K64	R:R:A204	3.21	No	No	1	5	5
208	N:N:K64	R:R:L230	4.23	No	Yes	1	5	4
209	N:N:Y65	R:R:E251	6.73	Yes	No	1	4	5
210	N:N:Y65	R:R:R274	4.12	Yes	No	1	4	3
211	N:N:Y65	R:R:T388	3.75	Yes	No	0	4	4
212	N:N:K107	N:N:S68	6.12	No	No	0	4	3
213	N:N:K104	N:N:T73	3	No	No	0	5	8
214	N:N:F77	N:N:Y74	7.22	Yes	Yes	0	4	8
215	N:N:A100	N:N:Y74	4	No	Yes	0	9	8
216	N:N:R75	N:N:S102	9.22	No	No	0	3	8
217	N:N:K104	N:N:R75	13.61	No	No	0	5	3
218	N:N:D76	N:N:L101	4.07	No	No	0	4	5
219	N:N:D76	N:N:S102	2.94	No	No	0	4	8
220	N:N:F77	N:N:Y79	6.19	Yes	No	0	4	8
221	N:N:F77	N:N:P98	4.33	Yes	No	0	4	9
222	N:N:F77	N:N:Y112	9.28	Yes	Yes	0	4	5
223	N:N:I78	N:N:L101	5.71	No	No	0	5	5
224	N:N:R80	N:N:Y97	8.23	No	Yes	0	5	6
225	N:N:T81	N:N:Y94	3.75	No	No	0	8	3
226	N:N:S96	N:N:T81	6.4	No	No	0	7	8
227	N:N:E83	N:N:P93	11	No	No	0	3	7
228	N:N:E83	N:N:Y94	10.1	No	No	0	3	3
229	N:N:I84	N:N:P85	3.39	No	No	0	6	8
230	N:N:C87	N:N:I84	3.27	No	No	0	9	6
231	N:N:C87	N:N:P93	3.77	No	No	0	9	7
232	N:N:H90	N:N:P88	6.1	No	No	0	5	5
233	N:N:H90	N:N:V91	13.84	No	No	19	5	7
234	N:N:F95	N:N:Y97	4.13	No	Yes	0	7	6
235	N:N:P98	N:N:Y97	4.17	No	Yes	0	9	6
236	N:N:V99	N:N:Y97	5.05	No	Yes	4	8	6
237	N:N:C108	N:N:S113	3.44	No	No	0	9	7
238	N:N:C108	N:N:C115	7.28	No	No	0	9	9
239	N:N:D111	N:N:N109	10.77	No	No	0	6	5
240	N:N:N109	N:N:Y112	15.12	No	Yes	0	5	5
241	N:N:T110	R:R:Y185	7.49	No	Yes	1	7	7
242	N:N:T110	R:R:K209	4.5	No	Yes	0	7	7
243	N:N:D111	R:R:K209	8.3	No	Yes	0	6	7
244	N:N:S113	N:N:Y112	6.36	No	Yes	18	7	5
245	N:N:D114	N:N:I116	7	Yes	Yes	1	9	7
246	N:N:D114	R:R:R109	4.76	Yes	Yes	1	9	5
247	N:N:D114	R:R:N110	4.04	Yes	Yes	1	9	6
248	N:N:I116	N:N:I120	2.94	Yes	No	0	7	3
249	N:N:I116	R:R:R109	6.26	Yes	Yes	1	7	5
250	N:N:E118	N:N:H117	3.69	Yes	No	0	5	5
251	N:N:E118	R:R:R38	8.14	Yes	Yes	0	5	4
252	N:N:E118	R:R:K58	6.75	Yes	Yes	0	5	5
253	N:N:I120	N:N:T122	4.56	No	Yes	0	3	4
254	N:N:I120	R:R:I60	2.94	No	Yes	0	3	4
255	N:N:K121	R:R:K42	4.31	No	No	0	2	2
256	N:N:T122	R:R:E61	7.06	Yes	No	0	4	5
257	N:N:K127	N:N:P128	3.35	No	No	0	5	6
258	R:R:M22	R:R:P52	5.03	No	No	0	2	3
259	R:R:C24	R:R:C31	7.28	No	No	0	9	8
260	R:R:S25	R:R:S26	4.89	No	No	0	7	8
261	R:R:P51	R:R:S25	7.13	Yes	No	0	5	7
262	R:R:I44	R:R:P28	3.39	Yes	No	0	5	2
263	R:R:C29	R:R:C41	7.28	No	No	0	9	9
264	R:R:C29	R:R:P48	3.77	No	Yes	6	9	9
265	R:R:C29	R:R:L50	3.17	No	Yes	6	9	5
266	R:R:E34	R:R:H32	6.15	No	Yes	1	4	5
267	R:R:H32	R:R:R38	3.39	Yes	Yes	1	5	4
268	R:R:H32	R:R:T40	6.85	Yes	Yes	1	5	8
269	R:R:E34	R:R:R38	6.98	No	Yes	1	4	4
270	R:R:D36	R:R:Q55	3.92	No	No	0	3	4
271	R:R:F37	R:R:Q55	4.68	No	No	0	1	4
272	R:R:R38	R:R:T56	5.17	Yes	No	0	4	5
273	R:R:P51	R:R:V39	3.53	Yes	Yes	6	5	6
274	R:R:T54	R:R:V39	4.76	No	Yes	6	7	6
275	R:R:L57	R:R:V39	2.98	Yes	Yes	0	7	6
276	R:R:K42	R:R:T40	3	No	Yes	0	2	8
277	R:R:K58	R:R:T40	7.51	Yes	Yes	1	5	8
278	R:R:I60	R:R:T40	3.04	Yes	Yes	1	4	8
279	R:R:C41	R:R:I44	6.55	No	Yes	0	9	5
280	R:R:C41	R:R:L59	3.17	No	Yes	0	9	6
281	R:R:D43	R:R:H63	7.56	No	No	0	4	4
282	R:R:I44	R:R:T62	4.56	Yes	Yes	16	5	7
283	R:R:I44	R:R:L64	7.14	Yes	Yes	16	5	6
284	R:R:H63	R:R:Q45	4.95	No	No	0	4	4
285	R:R:I47	R:R:P48	3.39	No	Yes	0	4	9
286	R:R:I47	R:R:L64	4.28	No	Yes	0	4	6
287	R:R:L50	R:R:P48	3.28	Yes	Yes	6	5	9
288	R:R:L50	R:R:P51	4.93	Yes	Yes	6	5	5
289	R:R:L50	R:R:L57	6.92	Yes	Yes	0	5	7
290	R:R:P51	R:R:T54	5.25	Yes	No	6	5	7
291	R:R:L75	R:R:T54	7.37	No	No	0	6	7
292	R:R:R80	R:R:T56	6.47	Yes	No	0	4	5
293	R:R:L57	R:R:L59	4.15	Yes	Yes	0	7	6
294	R:R:F72	R:R:L57	3.65	Yes	Yes	0	9	7
295	R:R:I60	R:R:K58	4.36	Yes	Yes	1	4	5
296	R:R:K58	R:R:Y82	10.75	Yes	Yes	1	5	4
297	R:R:L59	R:R:T62	2.95	Yes	Yes	0	6	7
298	R:R:L59	R:R:V83	8.94	Yes	No	0	6	6
299	R:R:I60	R:R:S84	7.74	Yes	No	0	4	7
300	R:R:E61	R:R:I85	4.1	No	Yes	0	5	6
301	R:R:L64	R:R:T62	7.37	Yes	Yes	16	6	7
302	R:R:D86	R:R:T62	8.67	Yes	Yes	16	8	7
303	R:R:D86	R:R:L64	5.43	Yes	Yes	16	8	6
304	R:R:R65	R:R:T88	3.88	No	No	0	4	4
305	R:R:Q91	R:R:T66	7.09	Yes	No	21	3	5
306	R:R:E93	R:R:T66	5.64	No	No	21	6	5
307	R:R:I67	R:R:P68	3.39	No	No	0	5	5
308	R:R:I67	R:R:S96	4.64	No	No	0	5	7
309	R:R:A71	R:R:P68	3.74	No	No	0	8	5
310	R:R:E93	R:R:S69	4.31	No	No	0	6	4
311	R:R:H70	R:R:H95	8.36	No	No	9	4	5
312	R:R:H70	R:R:Y98	3.27	No	Yes	9	4	2
313	R:R:A71	R:R:F72	8.32	No	Yes	0	8	9
314	R:R:F72	R:R:I81	10.05	Yes	No	20	9	8
315	R:R:F72	R:R:F97	6.43	Yes	No	20	9	9
316	R:R:F72	R:R:L100	6.09	Yes	No	0	9	8
317	R:R:N74	R:R:S73	4.47	No	No	0	4	4
318	R:R:N77	R:R:P76	6.52	No	No	17	8	5
319	R:R:I78	R:R:I81	4.42	No	No	0	7	8
320	R:R:R80	R:R:S79	5.27	Yes	No	0	4	7
321	R:R:R80	R:R:Y82	9.26	Yes	Yes	1	4	4
322	R:R:H105	R:R:R80	15.8	Yes	Yes	1	7	4
323	R:R:F97	R:R:I81	6.28	No	No	20	9	8
324	R:R:H105	R:R:Y82	7.62	Yes	Yes	1	7	4
325	R:R:E107	R:R:Y82	11.22	Yes	Yes	1	6	4
326	R:R:D86	R:R:V83	2.92	Yes	No	0	8	6
327	R:R:I108	R:R:V83	3.07	No	No	0	8	6
328	R:R:I85	R:R:S84	6.19	Yes	No	0	6	7
329	R:R:D86	R:R:L89	6.79	Yes	No	0	8	8
330	R:R:L114	R:R:L89	4.15	No	No	0	8	8
331	R:R:N113	R:R:Q90	6.6	No	No	0	4	4
332	R:R:E93	R:R:Q91	3.82	No	Yes	21	6	3
333	R:R:Q91	R:R:Y116	4.51	Yes	No	0	3	3
334	R:R:I117	R:R:L92	8.56	No	No	0	8	8
335	R:R:D118	R:R:S94	5.89	Yes	No	0	5	4
336	R:R:H95	R:R:Y98	13.07	No	Yes	9	5	2
337	R:R:F97	R:R:I106	8.79	No	No	0	9	7
338	R:R:N99	R:R:Y98	6.98	No	Yes	9	5	2
339	R:R:K123	R:R:Y98	3.58	No	Yes	0	4	2
340	R:R:L100	R:R:V103	5.96	No	No	0	8	5
341	R:R:K102	R:R:S101	3.06	No	No	0	4	4
342	R:R:I106	R:R:V103	3.07	No	No	0	7	5
343	R:R:L125	R:R:V103	2.98	No	No	0	8	5
344	R:R:K129	R:R:T104	3	No	No	0	5	5
345	R:R:E107	R:R:H105	9.85	Yes	Yes	1	6	7
346	R:R:F130	R:R:H105	16.97	Yes	Yes	1	6	7
347	R:R:I106	R:R:L131	4.28	No	No	0	7	8
348	R:R:E107	R:R:R109	4.65	Yes	Yes	1	6	5
349	R:R:E107	R:R:F130	5.83	Yes	Yes	1	6	6
350	R:R:I108	R:R:T111	3.04	No	No	0	8	5
351	R:R:N110	R:R:R109	7.23	Yes	Yes	1	6	5
352	R:R:F134	R:R:R109	25.66	Yes	Yes	1	5	5
353	R:R:N110	R:R:N135	5.45	Yes	Yes	1	6	8
354	R:R:L114	R:R:T111	7.37	No	No	0	8	5
355	R:R:T111	R:R:T136	4.71	No	Yes	0	5	9
356	R:R:D118	R:R:Y116	8.05	Yes	No	0	5	3
357	R:R:I117	R:R:L138	5.71	No	No	0	8	8
358	R:R:D118	R:R:P119	9.66	Yes	No	0	5	4
359	R:R:D118	R:R:D120	3.99	Yes	No	0	5	5
360	R:R:D143	R:R:P119	4.83	No	No	0	5	4
361	R:R:D120	R:R:K146	6.91	No	Yes	0	5	4
362	R:R:E124	R:R:Y148	4.49	No	No	0	4	4
363	R:R:L125	R:R:L128	4.15	No	Yes	0	8	9
364	R:R:L128	R:R:V147	4.47	Yes	No	0	9	7
365	R:R:L128	R:R:S149	3	Yes	No	3	9	8
366	R:R:F154	R:R:L128	4.87	Yes	Yes	3	6	9
367	R:R:D151	R:R:K129	12.44	No	No	0	4	5
368	R:R:F130	R:R:G132	4.52	Yes	No	1	6	5
369	R:R:F130	R:R:F134	3.22	Yes	Yes	1	6	5
370	R:R:F130	R:R:I155	5.02	Yes	No	1	6	5
371	R:R:E157	R:R:F130	7	Yes	Yes	1	8	6
372	R:R:L131	R:R:L156	4.15	No	Yes	0	8	7
373	R:R:F134	R:R:G132	4.52	Yes	No	1	5	5
374	R:R:I133	R:R:T136	3.04	No	Yes	0	8	9
375	R:R:I133	R:R:P142	3.39	No	Yes	3	8	9
376	R:R:I133	R:R:I158	7.36	No	Yes	3	8	7
377	R:R:E157	R:R:F134	10.49	Yes	Yes	1	8	5
378	R:R:F134	R:R:T159	7.78	Yes	No	0	5	5
379	R:R:D160	R:R:N135	8.08	Yes	Yes	1	8	8
380	R:R:G137	R:R:T136	3.64	No	Yes	0	8	9
381	R:R:L138	R:R:T136	5.9	No	Yes	0	8	9
382	R:R:N161	R:R:T136	5.85	Yes	Yes	0	8	9
383	R:R:G137	R:R:Y163	2.9	No	No	0	8	4
384	R:R:F141	R:R:P142	11.56	Yes	Yes	0	7	9
385	R:R:F141	R:R:P168	11.56	Yes	No	0	7	6
386	R:R:F141	R:R:F172	4.29	Yes	Yes	0	7	8
387	R:R:F141	R:R:F189	4.29	Yes	Yes	0	7	8
388	R:R:L144	R:R:P142	6.57	No	Yes	0	7	9
389	R:R:I158	R:R:P142	3.39	Yes	Yes	3	7	9
390	R:R:D143	R:R:T145	7.23	No	No	22	5	4
391	R:R:D143	R:R:K146	5.53	No	Yes	22	5	4
392	R:R:L144	R:R:L156	4.15	No	Yes	0	7	7
393	R:R:L144	R:R:L175	8.3	No	Yes	0	7	7
394	R:R:K146	R:R:T145	3	Yes	No	22	4	4
395	R:R:L175	R:R:V147	4.47	Yes	No	0	7	7
396	R:R:G174	R:R:Y148	2.9	No	No	0	9	4
397	R:R:F154	R:R:S149	5.28	Yes	No	3	6	8
398	R:R:C176	R:R:S149	3.44	No	No	3	6	8
399	R:R:N177	R:R:T150	2.92	No	Yes	13	5	3
400	R:R:E178	R:R:I152	6.83	Yes	No	0	5	3
401	R:R:F154	R:R:L175	9.74	Yes	Yes	0	6	7
402	R:R:C176	R:R:F154	5.59	No	Yes	3	6	6
403	R:R:F154	R:R:L180	4.87	Yes	Yes	3	6	7
404	R:R:I155	R:R:K183	2.91	No	Yes	0	5	6
405	R:R:I158	R:R:L156	8.56	Yes	Yes	3	7	7
406	R:R:F172	R:R:L156	3.65	Yes	Yes	3	8	7
407	R:R:L156	R:R:L182	4.15	Yes	Yes	3	7	6
408	R:R:E157	R:R:K183	9.45	Yes	Yes	0	8	6
409	R:R:I158	R:R:N161	4.25	Yes	Yes	3	7	8
410	R:R:I158	R:R:M164	2.92	Yes	Yes	3	7	7
411	R:R:I158	R:R:L184	4.28	Yes	No	0	7	8
412	R:R:D160	R:R:T159	10.12	Yes	No	0	8	5
413	R:R:T159	R:R:Y185	11.24	No	Yes	0	5	7
414	R:R:D160	R:R:N186	6.73	Yes	No	0	8	7
415	R:R:M164	R:R:N161	7.01	Yes	Yes	3	7	8
416	R:R:N161	R:R:N187	6.81	Yes	Yes	3	8	9
417	R:R:P162	R:R:Y163	6.95	No	No	0	7	4
418	R:R:M164	R:R:N187	4.21	Yes	Yes	3	7	9
419	R:R:F189	R:R:M164	6.22	Yes	Yes	3	8	7
420	R:R:S166	R:R:S191	4.89	No	No	0	5	4
421	R:R:Q193	R:R:S166	5.78	No	No	0	5	5
422	R:R:I167	R:R:P168	3.39	No	No	0	7	6
423	R:R:F189	R:R:I167	11.3	Yes	No	0	8	7
424	R:R:I167	R:R:V192	4.61	No	No	0	7	7
425	R:R:A171	R:R:P168	3.74	No	No	0	7	6
426	R:R:N170	R:R:V169	2.96	Yes	No	0	8	5
427	R:R:N170	R:R:Q173	15.85	Yes	Yes	12	8	2
428	R:R:N170	R:R:N198	5.45	Yes	Yes	12	8	7
429	R:R:A171	R:R:F172	8.32	No	Yes	0	7	8
430	R:R:F172	R:R:L175	4.87	Yes	Yes	0	8	7
431	R:R:F172	R:R:L182	9.74	Yes	Yes	3	8	6
432	R:R:F172	R:R:F197	4.29	Yes	No	0	8	9
433	R:R:N198	R:R:Q173	6.6	Yes	Yes	12	7	2
434	R:R:E178	R:R:N177	3.94	Yes	No	13	5	5
435	R:R:E178	R:R:K201	4.05	Yes	No	0	5	4
436	R:R:L180	R:R:L182	6.92	Yes	Yes	3	7	6
437	R:R:L180	R:R:T200	2.95	Yes	No	3	7	8
438	R:R:L180	R:R:L202	4.15	Yes	Yes	3	7	8
439	R:R:L182	R:R:L184	4.15	Yes	No	0	6	8
440	R:R:K183	R:R:Y185	3.58	Yes	Yes	0	6	7
441	R:R:K183	R:R:Y206	5.97	Yes	Yes	0	6	6
442	R:R:N208	R:R:Y185	8.14	Yes	Yes	1	5	7
443	R:R:K209	R:R:N186	5.6	Yes	No	0	7	7
444	R:R:F189	R:R:N187	16.92	Yes	Yes	3	8	9
445	R:R:N187	R:R:N210	4.09	Yes	No	3	9	9
446	R:R:F189	R:R:N210	8.46	Yes	No	3	8	9
447	R:R:S191	R:R:T190	3.2	No	No	0	4	5
448	R:R:D217	R:R:G194	5.03	No	No	0	5	3
449	R:R:N198	R:R:Y195	3.49	Yes	No	0	7	4
450	R:R:D219	R:R:Y195	10.34	No	No	0	3	4
451	R:R:G222	R:R:Y195	4.35	No	No	0	3	4
452	R:R:F197	R:R:L202	7.31	No	Yes	0	9	8
453	R:R:F197	R:R:F221	16.08	No	Yes	0	9	9
454	R:R:G199	R:R:N198	3.39	No	Yes	0	7	7
455	R:R:G223	R:R:N198	5.09	No	Yes	0	7	7
456	R:R:G199	R:R:Y225	7.24	No	No	0	7	4
457	R:R:L202	R:R:T200	7.37	Yes	No	3	8	8
458	R:R:K201	R:R:S226	4.59	No	No	0	4	4
459	R:R:L202	R:R:V205	4.47	Yes	No	0	8	7
460	R:R:D203	R:R:S229	2.94	Yes	No	0	6	5
461	R:R:A204	R:R:Y206	4	No	Yes	1	5	6
462	R:R:A204	R:R:L230	3.15	No	Yes	1	5	4
463	R:R:L207	R:R:V205	2.98	No	No	0	7	7
464	R:R:L231	R:R:V205	2.98	No	No	0	7	7
465	R:R:N208	R:R:Y206	3.49	Yes	Yes	1	5	6
466	R:R:L230	R:R:Y206	7.03	Yes	Yes	1	4	6
467	R:R:D232	R:R:Y206	6.9	Yes	Yes	1	9	6
468	R:R:K209	R:R:N208	8.39	Yes	Yes	0	7	5
469	R:R:D232	R:R:N208	13.46	Yes	Yes	1	9	5
470	R:R:K209	R:R:Q235	6.78	Yes	No	0	7	4
471	R:R:L213	R:R:N210	5.49	No	No	0	9	9
472	R:R:L213	R:R:V238	2.98	No	Yes	0	9	7
473	R:R:T214	R:R:V215	4.76	No	No	0	4	2
474	R:R:I216	R:R:V238	3.07	No	Yes	0	6	7
475	R:R:I216	R:R:P242	6.77	No	Yes	0	6	9
476	R:R:K218	R:R:S243	6.12	No	No	0	4	5
477	R:R:D219	R:R:K244	9.68	No	No	0	3	3
478	R:R:F221	R:R:P228	5.78	Yes	No	0	9	8
479	R:R:F221	R:R:P242	4.33	Yes	Yes	23	9	9
480	R:R:F221	R:R:L246	4.87	Yes	No	23	9	7
481	R:R:G227	R:R:P228	4.06	No	No	0	7	8
482	R:R:K250	R:R:S229	6.12	No	No	0	7	5
483	R:R:E251	R:R:L230	9.28	No	Yes	1	5	4
484	R:R:L231	R:R:V233	2.98	No	Yes	0	7	7
485	R:R:L231	R:R:L252	4.15	No	No	0	7	9
486	R:R:D232	R:R:S234	7.36	Yes	No	1	9	9
487	R:R:D232	R:R:I253	13.99	Yes	Yes	1	9	4
488	R:R:T236	R:R:V233	3.17	No	Yes	24	9	7
489	R:R:V233	R:R:V238	3.21	Yes	Yes	24	7	7
490	R:R:L241	R:R:V233	2.98	Yes	Yes	0	9	7
491	R:R:I253	R:R:S234	3.1	Yes	No	1	4	9
492	R:R:R255	R:R:S234	3.95	Yes	No	1	4	9
493	R:R:N256	R:R:Q235	6.6	No	No	0	5	4
494	R:R:T236	R:R:V238	7.93	No	Yes	24	9	7
495	R:R:T236	R:R:T257	4.71	No	No	0	9	8
496	R:R:S237	R:R:T259	3.2	No	No	0	4	5
497	R:R:L241	R:R:P242	4.93	Yes	Yes	0	9	9
498	R:R:L241	R:R:L252	4.15	Yes	No	0	9	9
499	R:R:L241	R:R:L260	4.15	Yes	No	0	9	9
500	R:R:L246	R:R:P242	3.28	No	Yes	23	7	9
501	R:R:K244	R:R:S243	4.59	No	No	0	3	5
502	R:R:E247	R:R:G245	4.91	No	No	0	4	9
503	R:R:F269	R:R:L249	3.65	Yes	No	0	7	8
504	R:R:H271	R:R:K250	3.93	No	No	0	5	7
505	R:R:K250	R:R:T273	3	No	No	0	7	4
506	R:R:E251	R:R:R274	9.3	No	No	1	5	3
507	R:R:I253	R:R:R255	6.26	Yes	Yes	1	4	4
508	R:R:D276	R:R:I253	7	Yes	Yes	1	4	4
509	R:R:A254	R:R:T257	3.36	No	No	0	8	8
510	R:R:N256	R:R:R255	3.62	No	Yes	0	5	4
511	R:R:D276	R:R:R255	13.1	Yes	Yes	1	4	4
512	R:R:S278	R:R:T257	3.2	No	No	0	9	8
513	R:R:S278	R:R:W258	3.71	No	No	0	9	4
514	R:R:W258	R:R:Y279	11.58	No	Yes	0	4	9
515	R:R:K261	R:R:Y279	3.58	No	Yes	0	8	9
516	R:R:K262	R:R:N483	5.6	No	No	0	5	8
517	R:R:L263	R:R:P264	4.93	No	No	0	8	9
518	R:R:L263	R:R:L277	4.15	No	No	26	8	9
519	R:R:H282	R:R:L263	7.71	No	No	26	9	8
520	R:R:F269	R:R:P264	4.33	Yes	No	0	7	9
521	R:R:E480	R:R:L265	6.63	No	No	0	6	7
522	R:R:L267	R:R:S266	4.5	No	No	0	5	5
523	R:R:F269	R:R:L267	15.83	Yes	No	0	7	5
524	R:R:F269	R:R:L272	7.31	Yes	No	25	7	8
525	R:R:F269	R:R:F286	8.57	Yes	Yes	25	7	8
526	R:R:H271	R:R:L270	5.14	No	No	0	5	3
527	R:R:F286	R:R:L272	7.31	Yes	No	25	8	8
528	R:R:K291	R:R:T273	9.01	No	No	0	7	4
529	R:R:D276	R:R:R274	9.53	Yes	No	1	4	3
530	R:R:A275	R:R:M396	3.22	No	Yes	0	9	6
531	R:R:D276	R:R:T399	7.23	Yes	No	0	4	4
532	R:R:H282	R:R:L277	3.86	No	No	26	9	9
533	R:R:P280	R:R:Y279	4.17	No	Yes	0	8	9
534	R:R:H282	R:R:Y279	5.44	No	Yes	0	9	9
535	R:R:I486	R:R:Y279	13.3	No	Yes	0	8	9
536	R:R:A485	R:R:S281	3.42	No	No	0	9	9
537	R:R:I486	R:R:S281	6.19	No	No	0	8	9
538	R:R:C283	R:R:C398	7.28	No	No	0	9	9
539	R:R:C284	R:R:C408	7.28	No	No	0	9	9
540	R:R:A285	R:R:F286	6.93	No	Yes	0	8	8
541	R:R:A285	R:R:Y482	8.01	No	No	0	8	8
542	R:R:F286	R:R:Q289	4.68	Yes	No	0	8	7
543	R:R:F286	R:R:M396	3.73	Yes	Yes	0	8	6
544	R:R:K287	R:R:N288	11.19	No	No	0	5	6
545	R:R:C408	R:R:K287	3.23	No	No	0	9	5
546	R:R:E394	R:R:K290	5.4	No	No	0	5	5
547	R:R:D392	R:R:K291	5.53	No	No	0	4	7
548	R:R:E297	R:R:R293	3.49	Yes	No	0	5	4
549	R:R:C390	R:R:R293	5.57	No	No	0	9	4
550	R:R:I295	R:R:L299	7.14	No	No	0	3	3
551	R:R:N302	R:R:S298	2.98	No	No	0	7	4
552	R:R:C301	R:R:M300	4.86	No	Yes	0	7	3
553	R:R:I389	R:R:M300	4.37	No	Yes	0	4	3
554	R:R:C301	R:R:C390	7.28	No	No	0	7	9
555	R:R:S304	R:R:S305	3.26	No	No	0	5	2
556	R:R:H384	R:R:T388	6.85	No	No	0	3	4
557	R:R:D386	R:R:Y385	4.6	No	Yes	1	5	4
558	R:R:I389	R:R:Y385	12.09	No	Yes	0	4	4
559	R:R:G391	R:R:Y387	5.79	No	No	0	5	4
560	R:R:D392	R:R:Y387	3.45	No	No	0	4	4
561	R:R:C390	R:R:I389	3.27	No	No	0	9	4
562	R:R:C398	R:R:M396	4.86	No	Yes	0	9	6
563	R:R:K401	R:R:T399	6.01	No	No	0	4	4
564	R:R:N406	R:R:S402	2.98	No	No	0	9	9
565	R:R:D403	R:R:F405	8.36	No	Yes	0	8	8
566	R:R:D403	R:R:N406	6.73	No	No	0	8	9
567	R:R:E404	W:W:?1	5.7	No	Yes	0	7	0
568	R:R:F405	R:R:K565	19.85	Yes	No	0	8	7
569	R:R:F405	R:R:V566	5.24	Yes	Yes	2	8	9
570	R:R:F405	R:R:M572	6.22	Yes	Yes	2	8	9
571	R:R:F405	W:W:?1	14.85	Yes	Yes	2	8	0
572	R:R:N406	R:R:Q489	9.24	No	No	0	9	9
573	R:R:E409	R:R:P407	9.43	Yes	No	0	9	9
574	R:R:P407	R:R:V656	5.3	No	No	0	9	7
575	R:R:E409	R:R:G413	3.27	Yes	No	0	9	9
576	R:R:E409	R:R:S657	10.06	Yes	No	0	9	8
577	R:R:E409	R:R:K660	5.4	Yes	No	0	9	9
578	R:R:D410	R:R:R418	8.34	No	No	0	9	9
579	R:R:D410	R:R:Y481	3.45	No	Yes	0	9	8
580	R:R:I411	R:R:I470	2.94	Yes	No	0	8	8
581	R:R:I411	R:R:V473	3.07	Yes	No	0	8	8
582	R:R:D474	R:R:I411	7	No	Yes	0	9	8
583	R:R:I411	R:R:T477	3.04	Yes	Yes	10	8	9
584	R:R:I411	R:R:Y481	7.25	Yes	Yes	10	8	8
585	R:R:M412	R:R:V421	7.61	Yes	No	7	8	9
586	R:R:I470	R:R:M412	4.37	No	Yes	0	8	8
587	R:R:D474	R:R:M412	9.7	No	Yes	0	9	8
588	R:R:M412	R:R:V664	3.04	Yes	Yes	7	8	9
589	R:R:F416	R:R:Y414	7.22	No	No	7	6	4
590	R:R:L417	R:R:Y414	8.21	Yes	No	7	9	4
591	R:R:N658	R:R:Y414	4.65	No	No	0	8	4
592	R:R:F416	R:R:L417	4.87	No	Yes	7	6	9
593	R:R:I661	R:R:L417	4.28	No	Yes	0	9	9
594	R:R:L417	R:R:V664	4.47	Yes	Yes	7	9	9
595	R:R:D474	R:R:R418	3.57	No	No	0	9	9
596	R:R:H478	R:R:R418	4.51	No	No	0	5	9
597	R:R:V421	R:R:V664	6.41	No	Yes	7	9	9
598	R:R:L426	R:R:W422	3.42	No	No	0	6	9
599	R:R:A471	R:R:W422	7.78	No	No	0	9	9
600	R:R:L475	R:R:W422	9.11	No	No	0	4	9
601	R:R:P668	R:R:V424	3.53	Yes	No	0	9	9
602	R:R:L429	R:R:S425	3	Yes	No	27	7	8
603	R:R:L467	R:R:S425	4.5	No	No	0	9	8
604	R:R:L468	R:R:S425	4.5	No	No	27	7	8
605	R:R:C672	R:R:L427	7.94	No	No	0	9	7
606	R:R:A428	R:R:S671	3.42	No	Yes	0	9	9
607	R:R:F461	R:R:L429	4.87	No	Yes	0	5	7
608	R:R:G464	R:R:L429	3.42	No	Yes	0	9	7
609	R:R:L429	R:R:L468	4.15	Yes	No	27	7	7
610	R:R:D460	R:R:N432	8.08	Yes	No	0	9	9
611	R:R:N432	R:R:P675	11.4	No	No	0	9	9
612	R:R:F434	R:R:I438	8.79	No	Yes	2	7	8
613	R:R:F434	R:R:F685	6.43	No	Yes	2	7	9
614	R:R:L439	R:R:V435	2.98	Yes	Yes	2	8	9
615	R:R:M453	R:R:V435	3.04	No	Yes	2	7	9
616	R:R:A679	R:R:V435	5.09	No	Yes	2	9	9
617	R:R:I680	R:R:V435	3.07	Yes	Yes	2	9	9
618	R:R:F685	R:R:V435	6.55	Yes	Yes	2	9	9
619	R:R:C454	R:R:L436	3.17	No	No	0	8	5
620	R:R:A457	R:R:L436	4.73	No	No	0	9	5
621	R:R:F685	R:R:I438	16.33	Yes	Yes	2	9	8
622	R:R:I438	R:R:V689	4.61	Yes	No	2	8	5
623	R:R:L439	R:R:R450	6.07	Yes	Yes	2	8	9
624	R:R:C454	R:R:L439	4.76	No	Yes	0	8	8
625	R:R:F685	R:R:L439	4.87	Yes	Yes	2	9	8
626	R:R:R450	R:R:S442	3.95	Yes	No	2	9	8
627	R:R:D688	R:R:S442	10.31	No	No	2	9	8
628	R:R:H443	R:R:Y444	18.51	No	No	0	5	7
629	R:R:R687	R:R:Y444	5.14	No	No	0	7	7
630	R:R:D688	R:R:Y444	4.6	No	No	0	9	7
631	R:R:L446	R:R:R450	3.64	No	Yes	0	6	9
632	R:R:F451	R:R:L446	4.87	No	No	0	9	6
633	R:R:N447	R:R:P449	13.03	No	No	0	8	8
634	R:R:N447	R:R:R450	10.85	No	Yes	0	8	9
635	R:R:P449	R:R:V448	3.53	No	Yes	0	8	9
636	R:R:L452	R:R:V448	2.98	Yes	Yes	0	9	9
637	R:R:I533	R:R:V448	3.07	No	Yes	0	5	9
638	R:R:A538	R:R:V448	5.09	No	Yes	0	9	9
639	R:R:E518	R:R:P449	11	No	No	0	9	8
640	R:R:D688	R:R:R450	4.76	No	Yes	2	9	9
641	R:R:F451	R:R:N455	7.25	No	Yes	2	9	8
642	R:R:F451	R:R:M542	4.98	No	Yes	2	9	9
643	R:R:L452	R:R:V514	5.96	Yes	Yes	2	9	6
644	R:R:I515	R:R:L452	7.14	No	Yes	0	9	9
645	R:R:L452	R:R:M542	4.24	Yes	Yes	2	9	9
646	R:R:M453	R:R:Y678	3.59	No	Yes	2	7	9
647	R:R:A679	R:R:M453	4.83	No	No	2	9	7
648	R:R:N455	R:R:T511	4.39	Yes	Yes	2	8	9
649	R:R:M542	R:R:N455	14.02	Yes	Yes	2	9	8
650	R:R:N455	R:R:W546	5.65	Yes	Yes	0	8	9
651	R:R:D460	R:R:L456	6.79	Yes	Yes	2	9	9
652	R:R:L456	R:R:S508	3	Yes	No	2	9	9
653	R:R:L456	R:R:T511	5.9	Yes	Yes	2	9	9
654	R:R:L456	R:R:N674	9.61	Yes	Yes	2	9	9
655	R:R:C462	R:R:F458	5.59	No	No	0	7	7
656	R:R:F458	R:R:W546	6.01	No	Yes	0	7	9
657	R:R:A459	R:R:L507	4.73	No	Yes	0	9	9
658	R:R:D460	R:R:S508	4.42	Yes	No	2	9	9
659	R:R:D460	R:R:S671	4.42	Yes	Yes	2	9	9
660	R:R:D460	R:R:N674	8.08	Yes	Yes	2	9	9
661	R:R:M463	R:R:Y466	3.59	Yes	Yes	2	9	9
662	R:R:M463	R:R:T501	3.01	Yes	Yes	2	9	9
663	R:R:M463	R:R:Y667	8.38	Yes	Yes	2	9	9
664	R:R:M463	R:R:P668	3.35	Yes	Yes	2	9	9
665	R:R:M463	R:R:S671	6.13	Yes	Yes	2	9	9
666	R:R:L467	R:R:Y466	3.52	No	Yes	0	9	9
667	R:R:T501	R:R:Y466	19.97	Yes	Yes	2	9	9
668	R:R:L663	R:R:Y466	5.86	No	Yes	0	9	9
669	R:R:L467	R:R:P668	4.93	No	Yes	0	9	9
670	R:R:L469	R:R:W488	3.42	No	Yes	0	7	9
671	R:R:I470	R:R:I568	2.94	No	Yes	0	8	9
672	R:R:V473	R:R:W488	15.94	No	Yes	0	8	9
673	R:R:T477	R:R:Y476	4.99	Yes	No	10	9	5
674	R:R:H484	R:R:Y476	6.53	No	No	10	6	5
675	R:R:T477	R:R:Y481	7.49	Yes	Yes	10	9	8
676	R:R:H484	R:R:T477	12.32	No	Yes	10	6	9
677	R:R:H478	R:R:S479	8.37	No	No	0	5	7
678	R:R:E480	R:R:N483	5.26	No	No	0	6	8
679	R:R:E480	R:R:H484	8.62	No	No	0	6	6
680	R:R:A485	R:R:Y481	6.67	No	Yes	0	9	8
681	R:R:Q489	R:R:Y481	3.38	No	Yes	0	9	8
682	R:R:S567	R:R:Y481	5.09	No	Yes	0	9	8
683	R:R:N483	R:R:Y482	11.63	No	No	0	8	8
684	R:R:G493	R:R:W488	4.22	No	Yes	0	9	9
685	R:R:C494	R:R:W488	7.84	No	Yes	28	9	9
686	R:R:C569	R:R:W488	5.22	No	Yes	28	9	9
687	R:R:G491	R:R:P492	4.06	No	No	0	8	3
688	R:R:C494	R:R:C569	7.28	No	No	28	9	9
689	R:R:L557	R:R:N495	4.12	No	No	0	7	5
690	R:R:A497	R:R:C569	3.61	No	No	0	9	9
691	R:R:G498	R:R:Y563	10.14	No	Yes	0	9	9
692	R:R:F499	R:R:F550	10.72	No	No	0	8	4
693	R:R:A553	R:R:F499	5.55	No	No	0	9	8
694	R:R:F499	R:R:L557	4.87	No	No	0	8	7
695	R:R:L570	R:R:T501	4.42	Yes	Yes	0	9	9
696	R:R:T501	R:R:Y667	6.24	Yes	Yes	2	9	9
697	R:R:A553	R:R:V502	3.39	No	No	0	9	9
698	R:R:V502	R:R:Y563	6.31	No	Yes	8	9	9
699	R:R:P571	R:R:V502	3.53	Yes	No	8	9	9
700	R:R:F503	R:R:W546	3.01	No	Yes	0	9	9
701	R:R:S505	R:R:Y667	7.63	No	Yes	0	9	9
702	R:R:C549	R:R:E506	3.04	No	Yes	0	8	8
703	R:R:E506	R:R:V586	7.13	Yes	No	0	8	7
704	R:R:E506	R:R:L589	3.98	Yes	No	0	8	3
705	R:R:E506	R:R:N590	11.83	Yes	No	0	8	9
706	R:R:L507	R:R:T511	2.95	Yes	Yes	0	9	9
707	R:R:L507	R:R:W546	10.25	Yes	Yes	0	9	9
708	R:R:C549	R:R:L507	3.17	No	Yes	0	8	9
709	R:R:N590	R:R:V509	7.39	No	No	0	9	8
710	R:R:V514	R:R:Y510	5.05	Yes	No	2	6	7
711	R:R:I541	R:R:Y510	3.63	No	No	2	7	7
712	R:R:G545	R:R:Y510	8.69	No	No	0	9	7
713	R:R:I515	R:R:T511	3.04	No	Yes	0	9	9
714	R:R:M542	R:R:T511	9.03	Yes	Yes	2	9	9
715	R:R:L512	R:R:V597	4.47	No	No	0	9	9
716	R:R:D633	R:R:L512	5.43	No	No	0	8	9
717	R:R:L512	R:R:Y678	3.52	No	Yes	0	9	9
718	R:R:L517	R:R:T513	2.95	No	Yes	29	5	9
719	R:R:A593	R:R:T513	3.36	No	Yes	0	9	9
720	R:R:I596	R:R:T513	3.04	No	Yes	29	6	9
721	R:R:T513	R:R:V597	4.76	Yes	No	0	9	9
722	R:R:I541	R:R:V514	3.07	No	Yes	2	7	6
723	R:R:M542	R:R:V514	4.56	Yes	Yes	2	9	6
724	R:R:I515	R:R:R519	3.76	No	No	0	9	9
725	R:R:T516	R:R:V597	12.69	No	No	0	9	9
726	R:R:T516	R:R:Y601	13.73	No	Yes	0	9	9
727	R:R:I596	R:R:L517	4.28	No	No	29	6	5
728	R:R:C600	R:R:L517	3.17	No	No	0	9	5
729	R:R:R519	R:R:Y601	7.2	No	Yes	2	9	9
730	R:R:R519	R:R:Y678	6.17	No	Yes	2	9	9
731	R:R:T524	R:R:W520	7.28	No	Yes	0	8	7
732	R:R:C600	R:R:W520	3.92	No	Yes	0	9	7
733	R:R:K603	R:R:W520	5.8	No	Yes	0	7	7
734	R:R:F525	R:R:Y521	10.32	No	No	0	6	6
735	R:R:R531	R:R:Y521	3.09	No	No	0	7	6
736	R:R:I533	R:R:Y521	8.46	No	No	0	5	6
737	R:R:I523	R:R:I604	10.3	No	No	0	9	9
738	R:R:I523	R:R:T607	3.04	No	No	0	9	7
739	R:R:F525	R:R:T524	3.89	No	No	0	6	8
740	R:R:D530	R:R:R528	13.1	No	No	0	8	7
741	R:R:R528	R:R:R531	18.13	No	No	0	7	7
742	R:R:R534	R:R:R536	8.53	No	No	0	7	5
743	R:R:H537	R:R:R534	9.03	No	No	0	7	7
744	R:R:L552	R:R:Y582	4.69	No	Yes	0	7	9
745	R:R:F585	R:R:L552	4.87	No	No	0	4	7
746	R:R:I560	R:R:L555	9.99	No	No	0	7	7
747	R:R:L555	R:R:Y582	5.86	No	Yes	0	7	9
748	R:R:P556	R:R:Y563	18.08	No	Yes	0	9	9
749	R:R:P556	R:R:Y582	12.52	No	Yes	0	9	9
750	R:R:L557	R:R:Y563	4.69	No	Yes	0	7	9
751	R:R:I560	R:R:L578	5.71	No	No	0	7	3
752	R:R:D573	R:R:S561	5.89	Yes	Yes	8	8	9
753	R:R:A579	R:R:S561	3.42	No	Yes	8	8	9
754	R:R:D573	R:R:S562	7.36	Yes	No	0	8	8
755	R:R:P571	R:R:Y563	8.34	Yes	Yes	8	9	9
756	R:R:I568	R:R:V566	6.14	Yes	Yes	2	9	9
757	R:R:M572	R:R:V566	9.13	Yes	Yes	2	9	9
758	R:R:V566	R:R:V656	4.81	Yes	No	0	9	7
759	R:R:K660	R:R:S567	3.06	No	No	0	9	9
760	R:R:I568	R:R:L570	5.71	Yes	Yes	0	9	9
761	R:R:I568	R:R:M572	2.92	Yes	Yes	2	9	9
762	R:R:I568	R:R:K660	4.36	Yes	No	0	9	9
763	R:R:I568	R:R:L663	5.71	Yes	No	0	9	9
764	R:R:L570	R:R:P571	3.28	Yes	Yes	0	9	9
765	R:R:L570	W:W:?1	4.96	Yes	Yes	0	9	0
766	R:R:I583	R:R:P571	3.39	No	Yes	0	7	9
767	R:R:M572	W:W:?1	8.11	Yes	Yes	2	9	0
768	R:R:D573	R:R:E575	9.09	Yes	No	0	8	4
769	R:R:A579	R:R:D573	4.63	No	Yes	8	8	8
770	R:R:I583	R:R:T574	3.04	No	No	0	7	6
771	R:R:T574	W:W:?1	9.51	No	Yes	0	6	0
772	R:R:P577	R:R:T576	3.5	No	No	0	3	6
773	R:R:L580	R:R:V584	2.98	No	No	0	4	5
774	R:R:I583	R:R:Y582	3.63	No	Yes	0	7	9
775	R:R:V586	R:R:Y582	6.31	No	Yes	0	7	9
776	R:R:A644	R:R:L587	3.15	No	No	0	9	8
777	R:R:L587	R:R:L645	4.15	No	No	0	8	7
778	R:R:I591	R:R:M637	2.92	No	No	0	6	7
779	R:R:I596	R:R:V592	3.07	No	No	0	6	3
780	R:R:C598	R:R:F594	6.98	No	Yes	0	7	8
781	R:R:D633	R:R:F594	8.36	No	Yes	0	8	8
782	R:R:F594	R:R:F634	7.5	Yes	No	0	8	9
783	R:R:F594	R:R:M637	11.2	Yes	No	0	8	7
784	R:R:L629	R:R:Y601	5.86	No	Yes	2	9	9
785	R:R:I630	R:R:Y601	6.04	No	Yes	0	9	9
786	R:R:Y601	R:R:Y678	2.98	Yes	Yes	2	9	9
787	R:R:R609	R:R:Y605	7.2	No	No	0	7	9
788	R:R:M626	R:R:Y605	5.99	No	No	0	9	9
789	R:R:D619	R:R:R609	8.34	No	No	0	9	7
790	R:R:K621	R:R:T620	3	No	No	0	6	7
791	R:R:K624	R:R:T620	3	No	No	0	9	7
792	R:R:L677	R:R:V628	4.47	No	No	0	9	6
793	R:R:L629	R:R:L677	4.15	No	No	0	9	9
794	R:R:L629	R:R:Y678	15.24	No	Yes	2	9	9
795	R:R:F631	R:R:I635	12.56	No	No	0	8	6
796	R:R:L677	R:R:T632	4.42	No	No	0	9	9
797	R:R:D633	R:R:N670	6.73	No	No	0	8	9
798	R:R:A638	R:R:F634	8.32	No	No	0	8	9
799	R:R:C636	R:R:N670	12.6	No	No	0	9	9
800	R:R:I640	R:R:Y667	4.84	No	Yes	2	9	9
801	R:R:I640	W:W:?1	3.07	No	Yes	2	9	0
802	R:R:F642	R:R:Y643	15.47	No	Yes	0	9	8
803	R:R:L653	R:R:Y643	4.69	No	Yes	0	9	8
804	R:R:I654	R:R:Y643	9.67	Yes	Yes	0	9	8
805	R:R:L662	R:R:Y643	3.52	No	Yes	0	8	8
806	R:R:A644	W:W:?1	4.52	No	Yes	0	9	0
807	R:R:A647	R:R:P652	3.74	No	No	2	9	9
808	R:R:A647	W:W:?1	4.52	No	Yes	2	9	0
809	R:R:I648	W:W:?1	5.12	No	Yes	0	6	0
810	R:R:P652	W:W:?1	8.24	No	Yes	2	9	0
811	R:R:I654	R:R:N658	5.66	Yes	No	0	9	8
812	R:R:I654	R:R:S659	4.64	Yes	No	2	9	9
813	R:R:I654	W:W:?1	3.07	Yes	Yes	2	9	0
814	R:R:N658	R:R:T655	5.85	No	No	0	8	8
815	R:R:S659	W:W:?1	4.31	No	Yes	2	9	0
816	R:R:F666	R:R:L662	4.87	No	No	0	8	8
817	R:R:L663	R:R:Y667	3.52	No	Yes	0	9	9
818	R:R:L665	R:R:V664	2.98	No	Yes	0	8	9
819	R:R:F666	R:R:L665	3.65	No	No	0	8	8
820	R:R:Y667	W:W:?1	5.04	Yes	Yes	2	9	0
821	R:R:P668	R:R:S671	5.34	Yes	Yes	2	9	9
822	R:R:N670	R:R:N674	8.17	No	Yes	0	9	9
823	R:R:N674	R:R:Y678	5.81	Yes	Yes	2	9	9
824	R:R:F676	R:R:I680	3.77	No	Yes	0	8	9
825	R:R:F685	R:R:I680	5.02	Yes	Yes	2	9	9
826	R:R:F685	R:R:V689	3.93	Yes	No	2	9	5
827	R:R:F690	R:R:Q686	3.51	No	No	0	5	7
828	R:R:L693	R:R:V689	2.98	No	No	0	7	5
829	R:R:F696	R:R:L692	4.87	No	No	0	4	8
830	R:R:F696	R:R:I698	3.77	No	No	0	4	3
831	R:R:D203	R:R:T179	2.89	Yes	No	0	6	5
832	R:R:D203	R:R:T181	2.89	Yes	No	0	6	7
833	R:R:K123	R:R:K146	2.87	No	Yes	0	4	4
834	R:R:K209	R:R:K211	2.87	Yes	No	0	7	3
835	R:R:E394	R:R:S393	2.87	No	No	0	5	3
836	R:R:I292	R:R:L270	2.85	No	No	0	5	3
837	R:R:I438	R:R:L437	2.85	Yes	No	0	8	3
838	L:L:I49	N:N:N57	2.83	No	Yes	1	5	7
839	R:R:H70	R:R:S73	2.79	No	No	0	4	4
840	L:L:H107	L:L:V85	2.77	No	No	0	8	9
841	R:R:D43	R:R:K42	2.77	No	No	0	4	2
842	R:R:L122	R:R:L125	2.77	No	No	0	7	8
843	R:R:L122	R:R:L131	2.77	No	No	0	7	8
844	R:R:D217	R:R:K218	2.77	No	No	0	5	4
845	R:R:H63	R:R:T88	2.74	No	No	0	4	4
846	L:L:N102	L:L:N90	2.72	Yes	No	0	9	4
847	H:H:?5	R:R:S53	2.69	Yes	No	0	0	5
848	R:R:F221	R:R:V224	2.62	Yes	No	0	9	7
849	R:R:R80	R:R:T104	2.59	Yes	No	0	4	5
850	R:R:F500	R:R:T496	2.59	No	No	0	7	5
851	R:R:Q90	R:R:Q91	2.56	No	Yes	0	4	3
852	H:H:?5	R:R:K102	2.53	Yes	No	0	0	4
853	R:R:F666	R:R:I635	2.51	No	No	0	8	6
854	N:N:K127	N:N:R34	2.48	No	No	0	5	4
855	R:R:F676	R:R:L427	2.44	No	No	0	8	7
856	R:R:F550	R:R:L554	2.44	No	No	0	4	5
857	L:L:L50	L:L:R38	2.43	No	No	0	5	4
858	N:N:D70	R:R:F381	2.39	No	No	0	4	4
859	R:R:K146	R:R:Y148	2.39	Yes	No	0	4	4
860	R:R:K201	R:R:Y225	2.39	No	No	0	4	4
861	R:R:M626	R:R:Y601	2.39	No	Yes	0	9	9
862	R:R:D36	R:R:R38	2.38	No	Yes	0	3	4
863	R:R:I604	R:R:W520	2.35	No	Yes	0	9	7
864	L:L:G96	L:L:G97	2.11	No	No	0	3	4
865	R:R:G544	R:R:G545	2.11	No	No	0	3	9
866	L:L:G46	L:L:P48	2.03	No	No	0	6	6
867	N:N:G86	N:N:P85	2.03	No	No	0	7	8
868	R:R:G431	R:R:P675	2.03	No	No	0	9	9
869	R:R:C548	R:R:G545	1.96	No	No	0	4	9
870	R:R:P27	R:R:P28	1.95	No	No	0	3	2
871	R:R:P51	R:R:P52	1.95	Yes	No	0	5	3
872	R:R:P280	R:R:P400	1.95	No	No	0	8	9
873	L:L:A47	L:L:P48	1.87	No	No	0	5	6
874	N:N:A92	N:N:P93	1.87	No	No	0	6	7
875	R:R:A638	R:R:P639	1.87	No	No	0	8	9
876	L:L:V100	N:N:G58	1.84	Yes	No	0	5	2
877	R:R:G544	R:R:V547	1.84	No	No	0	3	3
878	R:R:G559	R:R:V558	1.84	No	No	0	9	4
879	L:L:G97	L:L:T93	1.82	No	No	0	4	3
880	N:N:C22	N:N:C47	1.82	Yes	Yes	5	9	9
881	N:N:C22	N:N:C51	1.82	Yes	No	5	9	9
882	N:N:C103	N:N:C22	1.82	No	Yes	5	9	9
883	N:N:C105	N:N:C22	1.82	No	Yes	5	9	9
884	N:N:C47	N:N:C72	1.82	Yes	No	5	9	9
885	N:N:C51	N:N:C72	1.82	No	No	5	9	9
886	R:R:A504	R:R:C462	1.81	No	No	0	8	7
887	R:R:P51	R:R:S53	1.78	Yes	No	0	5	5
888	R:R:P556	R:R:S561	1.78	No	Yes	0	9	9
889	R:R:P571	R:R:S561	1.78	Yes	Yes	8	9	9
890	L:L:G54	L:L:M53	1.75	No	Yes	0	9	4
891	L:L:G54	N:N:M52	1.75	No	No	0	9	1
892	R:R:G23	R:R:M22	1.75	No	No	0	1	2
893	R:R:P126	R:R:T150	1.75	No	Yes	0	5	3
894	R:R:P492	R:R:T496	1.75	No	No	0	3	5
895	R:R:C284	R:R:S402	1.72	No	No	0	9	9
896	L:L:A105	L:L:S88	1.71	No	No	0	4	4
897	L:L:G96	R:R:L299	1.71	No	No	0	3	3
898	R:R:C31	R:R:V39	1.71	No	Yes	0	8	6
899	R:R:G245	R:R:L246	1.71	No	No	0	9	7
900	R:R:C539	R:R:V543	1.71	No	No	0	4	3
901	R:R:C599	R:R:V595	1.71	No	No	0	4	3
902	R:R:G188	R:R:N187	1.7	No	Yes	0	6	9
903	R:R:A196	R:R:V192	1.7	No	No	0	9	7
904	R:R:A220	R:R:V192	1.7	No	No	0	8	7
905	R:R:A471	R:R:V421	1.7	No	No	0	9	9
906	N:N:A100	N:N:T45	1.68	No	No	0	9	8
907	N:N:D70	N:N:G106	1.68	No	No	0	4	5
908	R:R:D487	R:R:G491	1.68	No	No	0	6	8
909	R:R:A579	R:R:T576	1.68	No	No	0	8	6
910	R:R:A673	R:R:T632	1.68	No	No	0	9	9
911	R:R:A684	R:R:T682	1.68	No	No	0	8	9
912	R:R:K651	R:R:P652	1.67	No	No	0	4	9
913	R:R:G174	R:R:Q173	1.64	No	Yes	0	9	2
914	R:R:G194	R:R:Q193	1.64	No	No	0	3	5
915	R:R:A121	R:R:I117	1.62	No	No	0	9	8
916	R:R:S191	R:R:V215	1.62	No	No	0	4	2
917	R:R:S472	R:R:V473	1.62	No	No	0	8	8
918	R:R:A240	R:R:K262	1.61	No	No	0	5	5
919	R:R:S166	R:R:T165	1.6	No	No	0	5	4
920	R:R:S237	R:R:T214	1.6	No	No	0	4	4
921	R:R:V420	R:R:V424	1.6	No	No	0	6	9
922	R:R:V420	R:R:V664	1.6	No	Yes	0	6	9
923	R:R:V543	R:R:V547	1.6	No	No	0	3	3
924	R:R:G227	R:R:H248	1.59	No	No	0	7	4
925	R:R:T399	R:R:V397	1.59	No	No	0	4	2
926	R:R:C454	R:R:L440	1.59	No	No	0	8	6
927	R:R:T588	R:R:V592	1.59	No	No	0	3	3
928	R:R:T607	R:R:V608	1.59	No	No	0	7	9
929	R:R:C636	R:R:L669	1.59	No	No	0	9	8
930	R:R:I691	R:R:S694	1.55	No	No	0	6	8
931	R:R:I560	R:R:V558	1.54	No	No	0	7	4
932	R:R:I648	R:R:V584	1.54	No	No	0	6	5
933	R:R:I622	R:R:V608	1.54	No	No	0	8	9
934	R:R:M637	R:R:S641	1.53	No	No	0	7	9
935	R:R:I486	R:R:T490	1.52	No	No	0	8	8
936	R:R:A564	R:R:Q489	1.52	No	No	0	7	9
937	L:L:E80	N:N:A119	1.51	No	No	0	9	5
938	N:N:F61	R:R:G294	1.51	Yes	No	0	3	5
939	N:N:A119	N:N:E118	1.51	No	Yes	0	5	5
940	R:R:A522	R:R:E518	1.51	No	No	0	8	9
941	R:R:K139	R:R:T115	1.5	No	No	0	4	4
942	R:R:L270	R:R:S268	1.5	No	No	0	3	5
943	R:R:L653	R:R:S646	1.5	No	No	0	9	9
944	R:R:L437	R:R:V433	1.49	No	No	0	3	3
945	R:R:L551	R:R:V547	1.49	No	No	0	2	3
946	R:R:L127	R:R:T150	1.47	No	Yes	0	4	3
947	R:R:I292	R:R:K290	1.45	No	No	0	5	5
948	R:R:D619	R:R:T620	1.45	No	No	0	9	7
949	R:R:P48	R:R:R46	1.44	Yes	No	0	9	1
950	R:R:I295	R:R:L296	1.43	No	No	0	3	4
951	R:R:I438	R:R:L692	1.43	Yes	No	0	8	8
952	R:R:I698	R:R:L693	1.43	No	No	0	3	7
953	L:L:M95	R:R:L299	1.41	No	No	0	3	3
954	R:R:E376	R:R:T377	1.41	No	No	0	4	3
955	R:R:K532	R:R:L529	1.41	No	No	0	8	8
956	R:R:D395	R:R:M396	1.39	No	Yes	0	3	6
957	R:R:L426	R:R:L430	1.38	No	No	0	6	5
958	R:R:A684	R:R:R450	1.38	No	Yes	0	8	9
959	R:R:A684	R:R:R687	1.38	No	No	0	8	7
960	R:R:I680	R:R:Q686	1.37	Yes	No	0	9	7
961	R:R:K683	R:R:Q686	1.36	No	No	0	8	7
962	N:N:A37	N:N:Y38	1.33	No	No	0	5	4
963	R:R:H443	R:R:I691	1.33	No	No	0	5	6
964	R:R:H537	R:R:I533	1.33	No	No	0	7	5
965	R:R:A623	R:R:Y605	1.33	No	No	0	9	9
966	N:N:F21	N:N:I23	1.26	No	No	0	1	4
967	R:R:F681	R:R:I680	1.26	No	Yes	0	8	9
968	R:R:T115	R:R:Y116	1.25	No	No	0	4	3
969	R:R:T190	R:R:Y212	1.25	No	No	0	5	3
970	R:R:E30	R:R:H32	1.23	No	Yes	0	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	H:H:?5	8.82	4	17	0
2	L:L:F41	7.296	5	1	1
3	L:L:F42	6.186	5	1	6
4	L:L:M53	5.038	5	1	4
5	L:L:Y61	7.348	5	4	8
6	L:L:T63	4.39	4	1	9
7	L:L:S67	3.65	4	1	7
8	L:L:M71	5.2925	4	1	9
9	L:L:V100	5.025	4	1	5
10	L:L:E101	9.075	4	1	5
11	L:L:N102	10.025	4	1	9
12	L:L:H103	8.174	5	1	9
13	L:L:C111	6.085	4	1	9
14	L:L:Y112	7.155	4	1	5
15	L:L:Y113	8.45	4	1	4
16	L:L:H114	7.6275	4	1	8
17	L:L:K115	6.98429	7	1	9
18	N:N:C22	2.912	5	5	9
19	N:N:Y27	10.3675	4	4	6
20	N:N:M29	4.54	5	4	7
21	N:N:H30	5.225	4	15	6
22	N:N:E32	8.664	5	15	9
23	N:N:I46	6.745	4	4	9
24	N:N:C47	4.075	4	5	9
25	N:N:R54	10.66	4	0	5
26	N:N:N57	5.46833	6	1	7
27	N:N:K59	8.1925	4	1	5
28	N:N:F61	5.6475	4	0	3
29	N:N:P63	5.085	4	1	4
30	N:N:Y65	5.3875	4	1	4
31	N:N:Q69	7.6675	4	1	9
32	N:N:Y74	5.7275	4	0	8
33	N:N:F77	6.755	4	0	4
34	N:N:Y97	5.71286	7	4	6
35	N:N:Y112	8.6375	4	18	5
36	N:N:D114	5.098	5	1	9
37	N:N:I116	5.488	5	1	7
38	N:N:E118	5.0225	4	0	5
39	N:N:T122	5.0175	4	1	4
40	R:R:H32	4.405	4	1	5
41	R:R:R38	5.212	5	1	4
42	R:R:V39	3.245	4	6	6
43	R:R:T40	5.1	4	1	8
44	R:R:I44	5.41	4	16	5
45	R:R:P48	2.97	4	6	9
46	R:R:L50	4.575	4	6	5
47	R:R:P51	4.095	6	6	5
48	R:R:L57	4.425	4	0	7
49	R:R:K58	7.3425	4	1	5
50	R:R:L59	4.8025	4	0	6
51	R:R:I60	4.52	4	1	4
52	R:R:T62	5.8875	4	16	7
53	R:R:L64	6.055	4	16	6
54	R:R:F72	6.908	5	20	9
55	R:R:R80	7.878	5	1	4
56	R:R:Y82	9.7125	4	1	4
57	R:R:I85	5.2525	4	0	6
58	R:R:D86	5.9525	4	16	8
59	R:R:Q91	4.495	4	21	3
60	R:R:Y98	6.222	5	9	2
61	R:R:H105	11.79	5	1	7
62	R:R:E107	7.8875	4	1	6
63	R:R:R109	8.71167	6	1	5
64	R:R:N110	6.2825	4	1	6
65	R:R:D118	6.8975	4	0	5
66	R:R:L128	4.1225	4	3	9
67	R:R:F130	7.55429	7	1	6
68	R:R:F134	9.43833	6	1	5
69	R:R:N135	5.554	5	1	8
70	R:R:T136	4.628	5	0	9
71	R:R:F141	7.925	4	0	7
72	R:R:P142	6.2275	4	3	9
73	R:R:K146	4.14	5	22	4
74	R:R:T150	2.8575	4	13	3
75	R:R:F154	6.07	5	3	6
76	R:R:L156	4.932	5	3	7
77	R:R:E157	9.0975	4	1	8
78	R:R:I158	5.12667	6	3	7
79	R:R:D160	7.522	5	1	8
80	R:R:N161	5.98	4	3	8
81	R:R:M164	5.09	4	3	7
82	R:R:N170	8.8375	4	12	8
83	R:R:F172	5.86	6	3	8
84	R:R:Q173	8.71	4	12	2
85	R:R:L175	6.845	4	0	7
86	R:R:E178	8.165	4	13	5
87	R:R:L180	4.7225	4	3	7
88	R:R:L182	6.24	4	3	6
89	R:R:K183	5.4775	4	0	6
90	R:R:Y185	7.046	5	1	7
91	R:R:N187	6.746	5	3	9
92	R:R:F189	9.438	5	3	8
93	R:R:N198	8.11	6	12	7
94	R:R:L202	5.825	4	3	8
95	R:R:D203	5.29	4	0	6
96	R:R:Y206	5.478	5	1	6
97	R:R:N208	8.37	4	1	5
98	R:R:K209	6.07333	6	0	7
99	R:R:F221	6.736	5	23	9
100	R:R:L230	5.9225	4	1	4
101	R:R:D232	10.4275	4	1	9
102	R:R:V233	3.085	4	24	7
103	R:R:V238	4.2975	4	24	7
104	R:R:L241	4.0525	4	0	9
105	R:R:P242	4.8275	4	23	9
106	R:R:I253	7.5875	4	1	4
107	R:R:R255	6.7325	4	1	4
108	R:R:F269	7.938	5	25	7
109	R:R:D276	9.215	4	1	4
110	R:R:Y279	7.614	5	0	9
111	R:R:F286	6.244	5	25	8
112	R:R:E297	4.505	4	1	5
113	R:R:M300	6.83	4	0	3
114	R:R:Y385	9.564	5	1	4
115	R:R:M396	3.3	4	0	6
116	R:R:F405	10.904	5	2	8
117	R:R:E409	7.04	4	0	9
118	R:R:I411	4.66	5	10	8
119	R:R:M412	6.18	4	7	8
120	R:R:L417	5.4575	4	7	9
121	R:R:L429	3.86	4	27	7
122	R:R:V435	4.146	5	2	9
123	R:R:I438	6.802	5	2	8
124	R:R:L439	4.67	4	2	8
125	R:R:V448	3.6675	4	0	9
126	R:R:R450	5.10833	6	2	9
127	R:R:L452	5.08	4	2	9
128	R:R:N455	7.8275	4	2	8
129	R:R:L456	6.325	4	2	9
130	R:R:D460	6.358	5	2	9
131	R:R:M463	4.892	5	2	9
132	R:R:Y466	8.235	4	2	9
133	R:R:T477	6.96	4	10	9
134	R:R:Y481	5.555	6	10	8
135	R:R:W488	7.328	5	28	9
136	R:R:T501	8.41	4	2	9
137	R:R:E506	6.495	4	0	8
138	R:R:L507	5.275	4	0	9
139	R:R:T511	5.062	5	2	9
140	R:R:T513	3.5275	4	29	9
141	R:R:V514	4.66	4	2	6
142	R:R:W520	4.8375	4	0	7
143	R:R:M542	7.366	5	2	9
144	R:R:W546	6.23	4	0	9
145	R:R:S561	3.2175	4	8	9
146	R:R:Y563	9.512	5	8	9
147	R:R:V566	6.33	4	2	9
148	R:R:I568	4.63	6	2	9
149	R:R:L570	4.5925	4	0	9
150	R:R:P571	4.064	5	8	9
151	R:R:M572	6.595	4	2	9
152	R:R:D573	6.7425	4	8	8
153	R:R:Y582	6.602	5	0	9
154	R:R:F594	8.51	4	0	8
155	R:R:Y601	6.36667	6	2	9
156	R:R:Y643	8.3375	4	0	8
157	R:R:I654	5.76	4	2	9
158	R:R:V664	3.7	5	7	9
159	R:R:Y667	5.94167	6	2	9
160	R:R:P668	4.2875	4	2	9
161	R:R:S671	4.8275	4	2	9
162	R:R:N674	7.9175	4	2	9
163	R:R:Y678	6.21833	6	2	9
164	R:R:I680	2.898	5	2	9
165	R:R:F685	7.18833	6	2	9
166	W:W:?1	6.23231	13	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:H103	N:N:N57	17.7912	8.93	Yes	Yes	1	9	7
2	L:L:E101	L:L:H103	22.105	7.39	Yes	Yes	1	5	9
3	L:L:E101	N:N:K59	46.3567	4.05	Yes	Yes	1	5	5
4	L:L:Y113	N:N:K59	47.424	8.36	Yes	Yes	1	4	5
5	L:L:Y112	L:L:Y113	47.7498	5.96	Yes	Yes	1	5	4
6	L:L:Y112	R:R:H105	12.6103	8.71	Yes	Yes	1	5	7
7	R:R:E107	R:R:H105	13.1232	9.85	Yes	Yes	1	6	7
8	R:R:E107	R:R:R109	29.0972	4.65	Yes	Yes	1	6	5
9	L:L:Y112	R:R:F130	35.2781	10.32	Yes	Yes	1	5	6
10	R:R:E107	R:R:F130	12.4476	5.83	Yes	Yes	1	6	6
11	R:R:F130	R:R:F134	23.5186	3.22	Yes	Yes	1	6	5
12	R:R:F134	R:R:R109	12.9176	25.66	Yes	Yes	1	5	5
13	L:L:E101	L:L:Y89	24.5719	20.2	Yes	No	0	5	4
14	L:L:R91	L:L:Y89	24.2084	5.14	No	No	0	4	4
15	L:L:R91	R:R:I152	23.8448	3.76	No	No	0	4	3
16	R:R:E178	R:R:I152	23.4811	6.83	Yes	No	0	5	3
17	R:R:E178	R:R:K201	20.2033	4.05	Yes	No	0	5	4
18	R:R:K201	R:R:Y225	19.4739	2.39	No	No	0	4	4
19	R:R:G199	R:R:Y225	19.109	7.24	No	No	0	7	4
20	R:R:G199	R:R:N198	18.744	3.39	No	Yes	0	7	7
21	R:R:N198	R:R:Q173	10.3183	6.6	Yes	Yes	12	7	2
22	R:R:N110	R:R:R109	44.5075	7.23	Yes	Yes	1	6	5
23	R:R:N110	R:R:N135	47.303	5.45	Yes	Yes	1	6	8
24	L:L:L72	R:R:N135	92.9176	4.12	No	Yes	0	3	8
25	L:L:L72	R:R:P162	92.9681	6.57	No	No	0	3	7
26	R:R:P162	R:R:Y163	92.9932	6.95	No	No	0	7	4
27	R:R:G137	R:R:Y163	93.0182	2.9	No	No	0	8	4
28	R:R:G137	R:R:T136	93.043	3.64	No	Yes	0	8	9
29	R:R:F134	R:R:T159	11.454	7.78	Yes	No	0	5	5
30	R:R:D160	R:R:T159	24.5227	10.12	Yes	No	0	8	5
31	R:R:D160	R:R:N135	35.4083	8.08	Yes	Yes	1	8	8
32	N:N:K64	R:R:D203	10.18	12.44	No	Yes	0	5	6
33	R:R:N208	R:R:Y206	12.7974	3.49	Yes	Yes	1	5	6
34	R:R:N161	R:R:T136	90.1167	5.85	Yes	Yes	0	8	9
35	R:R:N161	R:R:N187	88.6074	6.81	Yes	Yes	3	8	9
36	R:R:D160	R:R:N186	10.8114	6.73	Yes	No	0	8	7
37	R:R:N187	R:R:N210	89.4555	4.09	Yes	No	3	9	9
38	R:R:L213	R:R:N210	92.6424	5.49	No	No	0	9	9
39	R:R:L213	R:R:V238	92.6487	2.98	No	Yes	0	9	7
40	R:R:T236	R:R:V238	94.0819	7.93	No	Yes	24	9	7
41	R:R:T236	R:R:T257	99.9982	4.71	No	No	0	9	8
42	R:R:S278	R:R:T257	99.9993	3.2	No	No	0	9	8
43	R:R:S278	R:R:W258	99.9997	3.71	No	No	0	9	4
44	R:R:W258	R:R:Y279	100	11.58	No	Yes	0	4	9
45	R:R:I486	R:R:Y279	98.8092	13.3	No	Yes	0	8	9
46	R:R:I486	R:R:S281	98.805	6.19	No	No	0	8	9
47	R:R:A485	R:R:S281	98.8028	3.42	No	No	0	9	9
48	R:R:A485	R:R:Y481	98.801	6.67	No	Yes	0	9	8
49	R:R:I411	R:R:Y481	49.5941	7.25	Yes	Yes	10	8	8
50	R:R:I411	R:R:I470	48.3682	2.94	Yes	No	0	8	8
51	R:R:I470	R:R:I568	46.8012	2.94	No	Yes	0	8	9
52	R:R:I568	R:R:L570	35.59	5.71	Yes	Yes	0	9	9
53	R:R:S567	R:R:Y481	46.2015	5.09	No	Yes	0	9	8
54	R:R:K660	R:R:S567	46.1603	3.06	No	No	0	9	9
55	R:R:I568	R:R:K660	45.8917	4.36	Yes	No	0	9	9
56	R:R:L570	R:R:T501	26.2303	4.42	Yes	Yes	0	9	9
57	R:R:M463	R:R:T501	26.0657	3.01	Yes	Yes	2	9	9
58	R:R:I568	R:R:L663	53.6119	5.71	Yes	No	0	9	9
59	R:R:L663	R:R:Y466	27.1162	5.86	No	Yes	0	9	9
60	R:R:M463	R:R:Y466	25.9674	3.59	Yes	Yes	2	9	9
61	R:R:L663	R:R:Y667	26.3921	3.52	No	Yes	0	9	9
62	R:R:M463	R:R:Y667	26.36	8.38	Yes	Yes	2	9	9
63	R:R:M463	R:R:S671	77.4902	6.13	Yes	Yes	2	9	9
64	R:R:D460	R:R:S671	76.9055	4.42	Yes	Yes	2	9	9
65	R:R:D460	R:R:N674	36.9843	8.08	Yes	Yes	2	9	9
66	R:R:N674	R:R:Y678	31.3891	5.81	Yes	Yes	2	9	9
67	R:R:M453	R:R:Y678	16.2285	3.59	No	Yes	2	7	9
68	R:R:M453	R:R:V435	15.3467	3.04	No	Yes	2	7	9
69	R:R:D460	R:R:L456	37.7826	6.79	Yes	Yes	2	9	9
70	R:R:L456	R:R:T511	37.4348	5.9	Yes	Yes	2	9	9
71	R:R:F451	R:R:L446	10.5777	4.87	No	No	0	9	6
72	R:R:M542	R:R:T511	17.9234	9.03	Yes	Yes	2	9	9
73	R:R:L452	R:R:V448	14.0339	2.98	Yes	Yes	0	9	9
74	R:R:K209	R:R:N186	10.7252	5.6	Yes	No	0	7	7
75	R:R:L230	R:R:Y206	14.7697	7.03	Yes	Yes	1	4	6
76	R:R:T159	R:R:Y185	13.0253	11.24	No	Yes	0	5	7
77	L:L:M71	R:R:N135	10.1738	4.21	Yes	Yes	1	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	L:L:I49	5.12	1	No	No	0	5	1	0
H:H:?1	L:L:N102	25.87	1	No	Yes	0	9	1	0
H:H:?2	L:L:K68	3.8	11	No	No	0	6	1	0
H:H:?2	L:L:N76	28.34	11	No	No	0	9	1	0
H:H:?2	N:N:Y79	14.73	11	No	No	0	8	1	0
H:H:?3	N:N:N43	30.8	0	No	No	0	8	1	0
L:L:P32	R:R:L378	6.57	0	No	No	5	4	0	1
L:L:R37	R:R:L378	4.86	1	No	No	4	4	0	1
L:L:R40	R:R:D382	3.57	0	No	No	1	4	0	1
L:L:R40	R:R:D386	5.96	0	No	No	1	5	0	1
L:L:F41	R:R:M300	12.44	1	Yes	Yes	1	3	0	1
L:L:F41	R:R:Y385	11.35	1	Yes	Yes	1	4	0	1
L:L:F41	R:R:D386	4.78	1	Yes	No	1	5	0	1
L:L:F42	R:R:L296	4.87	1	Yes	No	6	4	0	1
L:L:M53	R:R:L378	4.24	1	Yes	No	4	4	0	1
L:L:S67	R:R:I85	4.64	1	Yes	Yes	7	6	0	1
L:L:T70	R:R:I85	6.08	0	No	Yes	9	6	0	1
L:L:T70	R:R:V87	3.17	0	No	No	9	4	0	1
L:L:M71	R:R:N110	8.41	1	Yes	Yes	9	6	0	1
L:L:M71	R:R:N135	4.21	1	Yes	Yes	9	8	0	1
L:L:L72	R:R:R112	6.07	0	No	No	3	6	0	1
L:L:L72	R:R:N135	4.12	0	No	Yes	3	8	0	1
L:L:L72	R:R:P162	6.57	0	No	No	3	7	0	1
L:L:V73	R:R:N135	5.91	1	No	Yes	7	8	0	1
L:L:V73	R:R:D160	4.38	1	No	Yes	7	8	0	1
L:L:K75	R:R:D160	8.3	1	No	Yes	9	8	0	1
L:L:R91	R:R:I152	3.76	0	No	No	4	3	0	1
L:L:E101	R:R:F153	4.66	1	Yes	No	5	5	0	1
L:L:Y112	R:R:H105	8.71	1	Yes	Yes	5	7	0	1
L:L:Y112	R:R:F130	10.32	1	Yes	Yes	5	6	0	1
L:L:Y112	R:R:I155	3.63	1	Yes	No	5	5	0	1
L:L:K115	R:R:R109	3.71	1	Yes	Yes	9	5	0	1
L:L:K115	R:R:F134	4.96	1	Yes	Yes	9	5	0	1
L:L:K115	R:R:E157	9.45	1	Yes	Yes	9	8	0	1
L:L:K115	R:R:Y185	4.78	1	Yes	Yes	9	7	0	1
N:N:M52	R:R:T377	3.01	0	No	No	1	3	0	1
N:N:M52	R:R:F381	11.2	0	No	No	1	4	0	1
N:N:R54	R:R:F381	20.31	0	Yes	No	5	4	0	1
N:N:R54	R:R:D382	3.57	0	Yes	No	5	4	0	1
N:N:R54	R:R:Y385	11.32	0	Yes	Yes	5	4	0	1
N:N:I56	R:R:Y385	8.46	0	No	Yes	5	4	0	1
N:N:K59	R:R:F153	16.13	1	Yes	No	5	5	0	1
N:N:L60	R:R:F153	3.65	0	No	No	3	5	0	1
N:N:F61	R:R:L296	10.96	0	Yes	No	3	4	0	1
N:N:F61	R:R:E297	5.83	0	Yes	Yes	3	5	0	1
N:N:L62	R:R:E297	3.98	1	No	Yes	3	5	0	1
N:N:L62	R:R:M300	5.65	1	No	Yes	3	3	0	1
N:N:P63	R:R:E297	4.72	1	Yes	Yes	4	5	0	1
N:N:K64	R:R:D203	12.44	1	No	Yes	5	6	0	1
N:N:K64	R:R:A204	3.21	1	No	No	5	5	0	1
N:N:K64	R:R:L230	4.23	1	No	Yes	5	4	0	1
N:N:Y65	R:R:E251	6.73	1	Yes	No	4	5	0	1
N:N:Y65	R:R:R274	4.12	1	Yes	No	4	3	0	1
N:N:Y65	R:R:T388	3.75	1	Yes	No	4	4	0	1
N:N:T110	R:R:Y185	7.49	1	No	Yes	7	7	0	1
N:N:T110	R:R:K209	4.5	1	No	Yes	7	7	0	1
N:N:D111	R:R:K209	8.3	0	No	Yes	6	7	0	1
N:N:D114	R:R:R109	4.76	1	Yes	Yes	9	5	0	1
N:N:D114	R:R:N110	4.04	1	Yes	Yes	9	6	0	1
N:N:I116	R:R:R109	6.26	1	Yes	Yes	7	5	0	1
N:N:E118	R:R:R38	8.14	0	Yes	Yes	5	4	0	1
N:N:E118	R:R:K58	6.75	0	Yes	Yes	5	5	0	1
N:N:I120	R:R:I60	2.94	0	No	Yes	3	4	0	1
N:N:K121	R:R:K42	4.31	0	No	No	2	2	0	1
N:N:T122	R:R:E61	7.06	1	Yes	No	4	5	0	1
R:R:E34	R:R:H32	6.15	1	No	Yes	4	5	2	2
R:R:H32	R:R:R38	3.39	1	Yes	Yes	5	4	2	1
R:R:H32	R:R:T40	6.85	1	Yes	Yes	5	8	2	2
R:R:E34	R:R:R38	6.98	1	No	Yes	4	4	2	1
R:R:R38	R:R:T56	5.17	1	Yes	No	4	5	1	2
R:R:K42	R:R:T40	3	0	No	Yes	2	8	1	2
R:R:K58	R:R:T40	7.51	1	Yes	Yes	5	8	1	2
R:R:I60	R:R:T40	3.04	1	Yes	Yes	4	8	1	2
R:R:R80	R:R:T56	6.47	1	Yes	No	4	5	2	2
R:R:I60	R:R:K58	4.36	1	Yes	Yes	4	5	1	1
R:R:K58	R:R:Y82	10.75	1	Yes	Yes	5	4	1	2
R:R:I60	R:R:S84	7.74	1	Yes	No	4	7	1	2
R:R:E61	R:R:I85	4.1	0	No	Yes	5	6	1	1
R:R:R80	R:R:Y82	9.26	1	Yes	Yes	4	4	2	2
R:R:H105	R:R:R80	15.8	1	Yes	Yes	7	4	1	2
R:R:H105	R:R:Y82	7.62	1	Yes	Yes	7	4	1	2
R:R:E107	R:R:Y82	11.22	1	Yes	Yes	6	4	2	2
R:R:I85	R:R:S84	6.19	0	Yes	No	6	7	1	2
R:R:E107	R:R:H105	9.85	1	Yes	Yes	6	7	2	1
R:R:F130	R:R:H105	16.97	1	Yes	Yes	6	7	1	1
R:R:E107	R:R:R109	4.65	1	Yes	Yes	6	5	2	1
R:R:E107	R:R:F130	5.83	1	Yes	Yes	6	6	2	1
R:R:N110	R:R:R109	7.23	1	Yes	Yes	6	5	1	1
R:R:F134	R:R:R109	25.66	1	Yes	Yes	5	5	1	1
R:R:N110	R:R:N135	5.45	1	Yes	Yes	6	8	1	1
R:R:F130	R:R:G132	4.52	1	Yes	No	6	5	1	2
R:R:F130	R:R:F134	3.22	1	Yes	Yes	6	5	1	1
R:R:F130	R:R:I155	5.02	1	Yes	No	6	5	1	1
R:R:E157	R:R:F130	7	1	Yes	Yes	8	6	1	1
R:R:F134	R:R:G132	4.52	1	Yes	No	5	5	1	2
R:R:E157	R:R:F134	10.49	1	Yes	Yes	8	5	1	1
R:R:F134	R:R:T159	7.78	1	Yes	No	5	5	1	2
R:R:D160	R:R:N135	8.08	1	Yes	Yes	8	8	1	1
R:R:E178	R:R:I152	6.83	13	Yes	No	5	3	2	1
R:R:I155	R:R:K183	2.91	1	No	Yes	5	6	1	2
R:R:E157	R:R:K183	9.45	1	Yes	Yes	8	6	1	2
R:R:D160	R:R:T159	10.12	1	Yes	No	8	5	1	2
R:R:T159	R:R:Y185	11.24	0	No	Yes	5	7	2	1
R:R:D160	R:R:N186	6.73	1	Yes	No	8	7	1	2
R:R:P162	R:R:Y163	6.95	0	No	No	7	4	1	2
R:R:K183	R:R:Y185	3.58	0	Yes	Yes	6	7	2	1
R:R:K183	R:R:Y206	5.97	0	Yes	Yes	6	6	2	2
R:R:N208	R:R:Y185	8.14	1	Yes	Yes	5	7	2	1
R:R:K209	R:R:N186	5.6	0	Yes	No	7	7	1	2
R:R:D203	R:R:S229	2.94	0	Yes	No	6	5	1	2
R:R:A204	R:R:Y206	4	1	No	Yes	5	6	1	2
R:R:A204	R:R:L230	3.15	1	No	Yes	5	4	1	1
R:R:N208	R:R:Y206	3.49	1	Yes	Yes	5	6	2	2
R:R:L230	R:R:Y206	7.03	1	Yes	Yes	4	6	1	2
R:R:K209	R:R:N208	8.39	0	Yes	Yes	7	5	1	2
R:R:K209	R:R:Q235	6.78	0	Yes	No	7	4	1	2
R:R:E251	R:R:L230	9.28	1	No	Yes	5	4	1	1
R:R:E251	R:R:R274	9.3	1	No	No	5	3	1	1
R:R:D276	R:R:R274	9.53	1	Yes	No	4	3	2	1
R:R:E297	R:R:R293	3.49	1	Yes	No	5	4	1	2
R:R:I295	R:R:L299	7.14	0	No	No	3	3	2	1
R:R:C301	R:R:M300	4.86	0	No	Yes	7	3	2	1
R:R:I389	R:R:M300	4.37	0	No	Yes	4	3	2	1
R:R:H384	R:R:T388	6.85	0	No	No	3	4	2	1
R:R:D386	R:R:Y385	4.6	1	No	Yes	5	4	1	1
R:R:I389	R:R:Y385	12.09	0	No	Yes	4	4	2	1
R:R:D203	R:R:T179	2.89	0	Yes	No	6	5	1	2
R:R:D203	R:R:T181	2.89	0	Yes	No	6	7	1	2
R:R:K209	R:R:K211	2.87	0	Yes	No	7	3	1	2
R:R:D43	R:R:K42	2.77	0	No	No	4	2	2	1
N:N:D70	R:R:F381	2.39	0	No	No	4	4	0	1
R:R:D36	R:R:R38	2.38	0	No	Yes	3	4	2	1
L:L:G96	R:R:L299	1.71	0	No	No	3	3	0	1
N:N:F61	R:R:G294	1.51	0	Yes	No	3	5	0	1
R:R:I295	R:R:L296	1.43	0	No	No	3	4	2	1
L:L:M95	R:R:L299	1.41	0	No	No	3	3	0	1
R:R:E376	R:R:T377	1.41	0	No	No	4	3	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D403	R:R:F405	8.36	0	No	Yes	8	8	2	1
R:R:E404	W:W:?1	5.7	0	No	Yes	7	0	1	0
R:R:F405	R:R:K565	19.85	2	Yes	No	8	7	1	2
R:R:F405	R:R:V566	5.24	2	Yes	Yes	8	9	1	2
R:R:F405	R:R:M572	6.22	2	Yes	Yes	8	9	1	1
R:R:F405	W:W:?1	14.85	2	Yes	Yes	8	0	1	0
R:R:M463	R:R:T501	3.01	2	Yes	Yes	9	9	2	2
R:R:M463	R:R:Y667	8.38	2	Yes	Yes	9	9	2	1
R:R:L570	R:R:T501	4.42	0	Yes	Yes	9	9	1	2
R:R:T501	R:R:Y667	6.24	2	Yes	Yes	9	9	2	1
R:R:S505	R:R:Y667	7.63	0	No	Yes	9	9	2	1
R:R:I568	R:R:V566	6.14	2	Yes	Yes	9	9	2	2
R:R:M572	R:R:V566	9.13	2	Yes	Yes	9	9	1	2
R:R:I568	R:R:L570	5.71	2	Yes	Yes	9	9	2	1
R:R:I568	R:R:M572	2.92	2	Yes	Yes	9	9	2	1
R:R:I568	R:R:L663	5.71	2	Yes	No	9	9	2	2
R:R:L570	R:R:P571	3.28	0	Yes	Yes	9	9	1	2
R:R:L570	W:W:?1	4.96	0	Yes	Yes	9	0	1	0
R:R:I583	R:R:P571	3.39	0	No	Yes	7	9	2	2
R:R:M572	W:W:?1	8.11	2	Yes	Yes	9	0	1	0
R:R:I583	R:R:T574	3.04	0	No	No	7	6	2	1
R:R:T574	W:W:?1	9.51	0	No	Yes	6	0	1	0
R:R:A644	R:R:L587	3.15	0	No	No	9	8	1	2
R:R:I640	R:R:Y667	4.84	2	No	Yes	9	9	1	1
R:R:I640	W:W:?1	3.07	2	No	Yes	9	0	1	0
R:R:I654	R:R:Y643	9.67	2	Yes	Yes	9	8	1	2
R:R:A644	W:W:?1	4.52	0	No	Yes	9	0	1	0
R:R:A647	R:R:P652	3.74	2	No	No	9	9	1	1
R:R:A647	W:W:?1	4.52	2	No	Yes	9	0	1	0
R:R:I648	W:W:?1	5.12	0	No	Yes	6	0	1	0
R:R:P652	W:W:?1	8.24	2	No	Yes	9	0	1	0
R:R:I654	R:R:N658	5.66	2	Yes	No	9	8	1	2
R:R:I654	R:R:S659	4.64	2	Yes	No	9	9	1	1
R:R:I654	W:W:?1	3.07	2	Yes	Yes	9	0	1	0
R:R:S659	W:W:?1	4.31	2	No	Yes	9	0	1	0
R:R:L663	R:R:Y667	3.52	0	No	Yes	9	9	2	1
R:R:Y667	W:W:?1	5.04	2	Yes	Yes	9	0	1	0
R:R:K651	R:R:P652	1.67	0	No	No	4	9	2	1
R:R:I648	R:R:V584	1.54	0	No	No	6	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7UTZ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.9
Number of Linked Nodes	768
Number of Links	970
Number of Hubs	166
Number of Links mediated by Hubs	576
Number of Communities	29
Number of Nodes involved in Communities	243
Number of Links involved in Communities	334

Path Summary
Number Of Nodes in MetaPath	78
Number Of Links MetaPath	77
Number of Shortest Paths	2613115
Length Of Smallest Path	3
Average Path Length	37.2957
Length of Longest Path	71
Minimum Path Strength	1.315
Average Path Strength	5.87636
Maximum Path Strength	20.66
Minimum Path Correlation	0.7
Average Path Correlation	0.98912
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.7027
Average % Of Corr. Nodes	46.4814
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.6176
Maximum Path Hubs %	100

Details about the values in these tables can be found in the corresponding documentation page .


Code	NAG
PDB Residues	H:H:?1 H:H:?2 H:H:?3 H:H:?4 H:H:?5 H:H:?6 H:H:?7
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylchitosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


Code	Z41
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	Z41
Name	(2S)-3-hydroxypropane-1,2-diyl dihexadecanoate
Synonyms
Identifier
Formula	C35 H68 O5
Molecular Weight	568.911
SMILES
PubChem	644078
Formal Charge	0
Total Atoms	108
Total Chiral Atoms	1
Total Bonds	107
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	L
Protein	TSH
UniProt	P01215
Sequence	>7UTZ_nogp_Chain_L C P E C T L R R N R F F S R P G A P I L Q C M G C C F S R A Y P T P L R S K K T M L V Q K N V T S E S T C C V A K S Y N R V T V M G G F K V E N H T A C H C S T C Y Y H K S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	N
Protein	TSH
UniProt	P01222
Sequence	>7UTZ_nogp_Chain_N F C I P T E Y T M H I E R R E C A Y C L T I N T T I C A G Y C M T R D I N G K L F L P K Y A L S Q D V C T Y R D F I Y R T V E I P G C P L H V A P Y F S Y P V A L S C K C G K C N T D Y S D C I H E A I K T N Y C T K P Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P16473
Sequence	>7UTZ_nogp_Chain_R G M G C S S P P C E C H Q E E D F R V T C K D I Q R I P S L P P S T Q T L K L I E T H L R T I P S H A F S N L P N I S R I Y V S I D V T L Q Q L E S H S F Y N L S K V T H I E I R N T R N L T Y I D P D A L K E L P L L K F L G I F N T G L K M F P D L T K V Y S T D I F F I L E I T D N P Y M T S I P V N A F Q G L C N E T L T L K L Y N N G F T S V Q G Y A F N G T K L D A V Y L N K N K Y L T V I D K D A F G G V Y S G P S L L D V S Q T S V T A L P S K G L E H L K E L I A R N T W T L K K L P L S L S F L H L T R A D L S Y P S H C C A F K N Q K K I R G I L E S L M C N E S S E T L Q A F D S H Y D Y T I C G D S E D M V C T P K S D E F N P C E D I M G Y K F L R I V V W F V S L L A L L G N V F V L L I L L T S H Y K L N V P R F L M C N L A F A D F C M G M Y L L L I A S V D L Y T H S E Y Y N H A I D W Q T G P G C N T A G F F T V F A S E L S V Y T L T V I T L E R W Y A I T F A M R L D R K I R L R H A C A I M V G G W V C C F L L A L L P L V G I S S Y A K V S I C L P M D T E T P L A L A Y I V F V L T L N I V A F V I V C C C Y V K I Y I T V R N D T K I A K R M A V L I F T D F I C M A P I S F Y A L S A I L N K P L I T V S N S K I L L V L F Y P L N S C A N P F L Y A I F T K A F Q R D V F I L L S K F G I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7T9I	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TSH	-	Gs/β1/γ2	2.9	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7T9I (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TSH	-		2.9	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7T9N	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	DPPC	Gs/β1/γ2	2.9	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7T9N (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	DPPC		2.9	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7UTZ	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TSH	DPPC	Gs/β1/γ2	2.4	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7UTZ (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TSH	DPPC		2.4	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7T9M	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	-	CS-17 Antibody	-	3.1	2022-08-10	doi.org/10.1038/s41586-022-05159-1
	7XW6	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	ML109	Gs/β1/γ2	2.78	2022-08-17	doi.org/10.1038/s41586-022-05173-3
	7XW6 (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	ML109		2.78	2022-08-17	doi.org/10.1038/s41586-022-05173-3
	7XW7	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	K1-70	-	-	5.5	2022-08-17	doi.org/10.1038/s41586-022-05173-3
	7XW5	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TSH	ML109	Gs/β1/γ2	2.96	2022-08-24	doi.org/10.1038/s41586-022-05173-3
	7XW5 (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TSH	ML109		2.96	2022-08-24	doi.org/10.1038/s41586-022-05173-3

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