Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:F17 7.296510
2L:L:F18 6.186510
3L:L:M29 5.038510
4L:L:Y37 7.348540
5L:L:T39 4.39410
6L:L:S43 3.65410
7L:L:M47 5.2925410
8L:L:V76 5.025410
9L:L:E77 9.075410
10L:L:H79 8.174510
11L:L:C87 6.085410
12L:L:Y88 7.155410
13L:L:Y89 8.45410
14L:L:H90 7.6275410
15L:L:K91 6.98429710
16M:M:C2 2.912550
17M:M:Y7 10.3675440
18M:M:M9 4.54540
19M:M:H10 5.2254110
20M:M:E12 8.6645110
21M:M:I26 6.745440
22M:M:C27 4.075450
23M:M:R34 10.66400
24M:M:N37 5.46833610
25M:M:K39 8.1925410
26M:M:F41 5.6475400
27M:M:P43 5.085410
28M:M:Y45 5.3875410
29M:M:Q49 7.6675410
30M:M:Y54 5.7275400
31M:M:F57 6.755400
32M:M:Y77 5.71286740
33M:M:Y92 8.63754130
34M:M:D94 5.098510
35M:M:I96 5.488510
36M:M:E98 5.0225400
37M:M:T102 5.0175410
38R:R:H32 4.405415
39R:R:R38 5.212514
40R:R:V39 3.245466
41R:R:T40 5.1418
42R:R:I44 5.414125
43R:R:P48 2.97469
44R:R:L50 4.575465
45R:R:P51 4.095665
46R:R:L57 4.425407
47R:R:K58 7.3425415
48R:R:L59 4.8025406
49R:R:I60 4.52414
50R:R:T62 5.88754127
51R:R:L64 6.0554126
52R:R:F72 6.9085159
53R:R:R80 7.878514
54R:R:Y82 9.7125414
55R:R:I85 5.2525406
56R:R:D86 5.95254128
57R:R:Q91 4.4954163
58R:R:Y98 6.7254172
59R:R:H105 11.79517
60R:R:E107 7.8875416
61R:R:R109 8.71167615
62R:R:N110 6.2825416
63R:R:D118 6.8975405
64R:R:L128 4.1225439
65R:R:F130 7.55429716
66R:R:F134 9.43833615
67R:R:N135 5.554518
68R:R:T136 4.628509
69R:R:F141 7.925407
70R:R:P142 6.2275439
71R:R:K146 4.145184
72R:R:F154 6.07536
73R:R:L156 4.932537
74R:R:E157 9.0975418
75R:R:I158 5.12667637
76R:R:D160 7.522518
77R:R:N161 5.98438
78R:R:M164 5.09437
79R:R:F172 5.86638
80R:R:L175 6.845407
81R:R:L180 4.7225437
82R:R:L182 6.24436
83R:R:K183 5.4775406
84R:R:Y185 7.046517
85R:R:N187 6.746539
86R:R:F189 9.438538
87R:R:N198 4.8045197
88R:R:L202 5.825438
89R:R:D203 5.29406
90R:R:Y206 5.478516
91R:R:N208 8.37415
92R:R:K209 6.07333607
93R:R:F221 6.7365209
94R:R:L230 5.9225414
95R:R:D232 10.4275419
96R:R:V233 3.0854217
97R:R:V238 4.29754217
98R:R:L241 4.0525409
99R:R:P242 4.82754209
100R:R:I253 7.5875414
101R:R:R255 6.7325414
102R:R:F269 7.9385227
103R:R:D276 9.215414
104R:R:Y279 7.614509
105R:R:F286 6.2445228
106R:R:E297 4.505415
107R:R:M300 6.83403
108R:R:Y385 9.564514
109R:R:M396 3.3406
110R:R:F405 10.904528
111R:R:E409 7.04409
112R:R:I411 4.66598
113R:R:M412 6.18478
114R:R:L417 5.4575479
115R:R:L429 3.864247
116R:R:V435 4.146529
117R:R:I438 6.802528
118R:R:L439 4.67428
119R:R:V448 3.6675409
120R:R:R450 5.10833629
121R:R:L452 5.08429
122R:R:N455 7.8275428
123R:R:L456 6.325429
124R:R:D460 6.358529
125R:R:M463 4.892529
126R:R:Y466 8.235429
127R:R:T477 6.96499
128R:R:Y481 5.555698
129R:R:W488 7.3285259
130R:R:T501 8.41429
131R:R:E506 6.495408
132R:R:L507 5.275409
133R:R:T511 5.062529
134R:R:T513 3.52754269
135R:R:V514 4.66426
136R:R:W520 4.8375407
137R:R:M542 7.366529
138R:R:W546 6.23409
139R:R:S561 3.2175489
140R:R:Y563 9.512589
141R:R:V566 6.33429
142R:R:I568 4.63629
143R:R:L570 4.5925409
144R:R:P571 4.064589
145R:R:M572 6.595429
146R:R:D573 6.7425488
147R:R:Y582 6.602509
148R:R:F594 8.51408
149R:R:Y601 6.36667629
150R:R:Y643 8.3375408
151R:R:I654 5.76429
152R:R:V664 3.7579
153R:R:Y667 5.94167629
154R:R:P668 4.2875429
155R:R:S671 4.8275429
156R:R:N674 7.9175429
157R:R:Y678 6.21833629
158R:R:I680 2.898529
159R:R:F685 7.18833629
160W:W:?1 6.232311320
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:E107 R:R:R109 28.47944.65YesYes165
2R:R:E107 R:R:H105 12.78029.85YesYes167
3L:L:Y88 R:R:H105 12.23988.71YesYes107
4L:L:Y88 L:L:Y89 46.29215.96YesYes100
5L:L:Y89 M:M:K39 45.92058.36YesYes100
6L:L:E77 M:M:K39 44.8294.05YesYes100
7L:L:E77 L:L:H79 22.21187.39YesYes100
8L:L:H79 M:M:N37 17.80278.93YesYes100
9R:R:E107 R:R:F130 12.09055.83YesYes166
10L:L:Y88 R:R:F130 34.21710.32YesYes106
11R:R:F134 R:R:R109 12.566825.66YesYes155
12R:R:F130 R:R:F134 22.83413.22YesYes165
13R:R:L230 R:R:Y206 15.09597.03YesYes146
14R:R:N208 R:R:Y206 13.0833.49YesYes156
15R:R:N110 R:R:R109 43.80627.23YesYes165
16L:L:M47 R:R:N135 10.33164.21YesYes108
17L:L:L48 R:R:N135 92.45244.12NoYes008
18L:L:L48 R:R:P162 92.50696.57NoNo007
19R:R:D160 R:R:N135 35.41368.08YesYes188
20L:L:E77 L:L:Y65 22.880120.2YesNo000
21L:L:R67 L:L:Y65 22.5085.14NoNo000
22L:L:R67 R:R:I152 22.13593.76NoNo003
23M:M:K44 R:R:D203 10.396512.44NoYes006
24R:R:P162 R:R:Y163 92.5346.95NoNo074
25R:R:G137 R:R:Y163 92.56092.9NoNo084
26R:R:G137 R:R:T136 92.58783.64NoYes089
27R:R:E178 R:R:I152 21.76366.83NoNo053
28R:R:E178 R:R:K201 19.90084.05NoNo054
29R:R:K201 R:R:Y225 19.1552.39NoNo044
30R:R:G199 R:R:Y225 18.78197.24NoNo074
31R:R:G199 R:R:N198 18.40873.39NoYes077
32R:R:N198 R:R:Q173 10.17086.6YesNo1972
33R:R:N161 R:R:T136 89.72755.85YesYes089
34R:R:F134 R:R:T159 11.147.78YesNo055
35R:R:N161 R:R:N187 88.25316.81YesYes389
36R:R:D160 R:R:N186 10.81676.73YesNo087
37R:R:N187 R:R:N210 89.13794.09YesNo399
38R:R:L213 R:R:N210 92.41415.49NoNo099
39R:R:L213 R:R:V238 92.42252.98NoYes097
40R:R:T236 R:R:V238 93.91017.93NoYes2197
41R:R:T236 R:R:T257 99.99054.71NoNo098
42R:R:S278 R:R:T257 99.99553.2NoNo098
43R:R:S278 R:R:W258 99.99783.71NoNo094
44R:R:W258 R:R:Y279 10011.58NoYes049
45R:R:I486 R:R:Y279 98.824513.3NoYes089
46R:R:I486 R:R:S281 98.8246.19NoNo089
47R:R:A485 R:R:S281 98.82373.42NoNo099
48R:R:A485 R:R:Y481 98.82376.67NoYes098
49R:R:I411 R:R:Y481 49.60867.25YesYes988
50R:R:I411 R:R:I470 48.41042.94YesNo088
51R:R:I470 R:R:I568 46.84462.94NoYes089
52R:R:I568 R:R:L570 35.61485.71YesYes099
53R:R:S567 R:R:Y481 46.21365.09NoYes098
54R:R:K660 R:R:S567 46.17313.06NoNo099
55R:R:I568 R:R:K660 45.90864.36YesNo099
56R:R:L570 R:R:T501 26.25144.42YesYes099
57R:R:M463 R:R:T501 26.08613.01YesYes299
58R:R:I568 R:R:L663 53.64755.71YesNo099
59R:R:L663 R:R:Y466 27.13485.86NoYes099
60R:R:M463 R:R:Y466 25.98513.59YesYes299
61R:R:L663 R:R:Y667 26.41013.52NoYes099
62R:R:M463 R:R:Y667 26.38878.38YesYes299
63R:R:M463 R:R:S671 77.55526.13YesYes299
64R:R:D460 R:R:S671 76.97754.42YesYes299
65R:R:D460 R:R:N674 37.01968.08YesYes299
66R:R:N674 R:R:Y678 31.42045.81YesYes299
67R:R:M453 R:R:Y678 16.2483.59NoYes279
68R:R:M453 R:R:V435 15.3653.04NoYes279
69R:R:D460 R:R:L456 37.81826.79YesYes299
70R:R:L456 R:R:T511 37.47245.9YesYes299
71R:R:F451 R:R:L446 10.59174.87NoNo096
72R:R:M542 R:R:T511 17.94349.03YesYes299
73R:R:L452 R:R:V448 14.05072.98YesYes099
74R:R:N110 R:R:N135 46.67275.45YesYes168
75R:R:D160 R:R:T159 24.518810.12YesNo085
76R:R:T159 R:R:Y185 13.333711.24NoYes057
77R:R:K209 R:R:N186 10.72885.6YesNo077
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:P8 R:R:L378 6.57 0 No No 0 4 0 1
L:L:R13 R:R:L378 4.86 1 No No 0 4 0 1
L:L:R16 R:R:D382 3.57 0 No No 0 4 0 1
L:L:R16 R:R:D386 5.96 0 No No 0 5 0 1
L:L:F17 R:R:M300 12.44 1 Yes Yes 0 3 0 1
L:L:F17 R:R:Y385 11.35 1 Yes Yes 0 4 0 1
L:L:F17 R:R:D386 4.78 1 Yes No 0 5 0 1
L:L:F18 R:R:L296 4.87 1 Yes No 0 4 0 1
L:L:M29 R:R:L378 4.24 1 Yes No 0 4 0 1
L:L:S43 R:R:I85 4.64 1 Yes Yes 0 6 0 1
L:L:T46 R:R:I85 6.08 0 No Yes 0 6 0 1
L:L:T46 R:R:V87 3.17 0 No No 0 4 0 1
L:L:M47 R:R:N110 8.41 1 Yes Yes 0 6 0 1
L:L:M47 R:R:N135 4.21 1 Yes Yes 0 8 0 1
L:L:L48 R:R:R112 6.07 0 No No 0 6 0 1
L:L:L48 R:R:N135 4.12 0 No Yes 0 8 0 1
L:L:L48 R:R:P162 6.57 0 No No 0 7 0 1
L:L:V49 R:R:N135 5.91 1 No Yes 0 8 0 1
L:L:V49 R:R:D160 4.38 1 No Yes 0 8 0 1
L:L:K51 R:R:D160 8.3 1 No Yes 0 8 0 1
L:L:R67 R:R:I152 3.76 0 No No 0 3 0 1
L:L:E77 R:R:F153 4.66 1 Yes No 0 5 0 1
L:L:Y88 R:R:H105 8.71 1 Yes Yes 0 7 0 1
L:L:Y88 R:R:F130 10.32 1 Yes Yes 0 6 0 1
L:L:Y88 R:R:I155 3.63 1 Yes No 0 5 0 1
L:L:K91 R:R:R109 3.71 1 Yes Yes 0 5 0 1
L:L:K91 R:R:F134 4.96 1 Yes Yes 0 5 0 1
L:L:K91 R:R:E157 9.45 1 Yes Yes 0 8 0 1
L:L:K91 R:R:Y185 4.78 1 Yes Yes 0 7 0 1
M:M:M32 R:R:T377 3.01 0 No No 0 3 0 1
M:M:M32 R:R:F381 11.2 0 No No 0 4 0 1
M:M:R34 R:R:F381 20.31 0 Yes No 0 4 0 1
M:M:R34 R:R:D382 3.57 0 Yes No 0 4 0 1
M:M:R34 R:R:Y385 11.32 0 Yes Yes 0 4 0 1
M:M:I36 R:R:Y385 8.46 0 No Yes 0 4 0 1
M:M:K39 R:R:F153 16.13 1 Yes No 0 5 0 1
M:M:L40 R:R:F153 3.65 0 No No 0 5 0 1
M:M:F41 R:R:L296 10.96 0 Yes No 0 4 0 1
M:M:F41 R:R:E297 5.83 0 Yes Yes 0 5 0 1
M:M:L42 R:R:E297 3.98 1 No Yes 0 5 0 1
M:M:L42 R:R:M300 5.65 1 No Yes 0 3 0 1
M:M:P43 R:R:E297 4.72 1 Yes Yes 0 5 0 1
M:M:K44 R:R:D203 12.44 1 No Yes 0 6 0 1
M:M:K44 R:R:A204 3.21 1 No No 0 5 0 1
M:M:K44 R:R:L230 4.23 1 No Yes 0 4 0 1
M:M:Y45 R:R:E251 6.73 1 Yes No 0 5 0 1
M:M:Y45 R:R:R274 4.12 1 Yes No 0 3 0 1
M:M:Y45 R:R:T388 3.75 1 Yes No 0 4 0 1
M:M:T90 R:R:Y185 7.49 1 No Yes 0 7 0 1
M:M:T90 R:R:K209 4.5 1 No Yes 0 7 0 1
M:M:D91 R:R:K209 8.3 0 No Yes 0 7 0 1
M:M:D94 R:R:R109 4.76 1 Yes Yes 0 5 0 1
M:M:D94 R:R:N110 4.04 1 Yes Yes 0 6 0 1
M:M:I96 R:R:R109 6.26 1 Yes Yes 0 5 0 1
M:M:E98 R:R:R38 8.14 0 Yes Yes 0 4 0 1
M:M:E98 R:R:K58 6.75 0 Yes Yes 0 5 0 1
M:M:I100 R:R:I60 2.94 0 No Yes 0 4 0 1
M:M:K101 R:R:K42 4.31 0 No No 0 2 0 1
M:M:T102 R:R:E61 7.06 1 Yes No 0 5 0 1
R:R:E34 R:R:H32 6.15 1 No Yes 4 5 2 2
R:R:H32 R:R:R38 3.39 1 Yes Yes 5 4 2 1
R:R:H32 R:R:T40 6.85 1 Yes Yes 5 8 2 2
R:R:E34 R:R:R38 6.98 1 No Yes 4 4 2 1
R:R:R38 R:R:T56 5.17 1 Yes No 4 5 1 2
R:R:K42 R:R:T40 3 0 No Yes 2 8 1 2
R:R:K58 R:R:T40 7.51 1 Yes Yes 5 8 1 2
R:R:I60 R:R:T40 3.04 1 Yes Yes 4 8 1 2
R:R:R80 R:R:T56 6.47 1 Yes No 4 5 2 2
R:R:I60 R:R:K58 4.36 1 Yes Yes 4 5 1 1
R:R:K58 R:R:Y82 10.75 1 Yes Yes 5 4 1 2
R:R:I60 R:R:S84 7.74 1 Yes No 4 7 1 2
R:R:E61 R:R:I85 4.1 0 No Yes 5 6 1 1
R:R:R80 R:R:Y82 9.26 1 Yes Yes 4 4 2 2
R:R:H105 R:R:R80 15.8 1 Yes Yes 7 4 1 2
R:R:H105 R:R:Y82 7.62 1 Yes Yes 7 4 1 2
R:R:E107 R:R:Y82 11.22 1 Yes Yes 6 4 2 2
R:R:I85 R:R:S84 6.19 0 Yes No 6 7 1 2
R:R:E107 R:R:H105 9.85 1 Yes Yes 6 7 2 1
R:R:F130 R:R:H105 16.97 1 Yes Yes 6 7 1 1
R:R:E107 R:R:R109 4.65 1 Yes Yes 6 5 2 1
R:R:E107 R:R:F130 5.83 1 Yes Yes 6 6 2 1
R:R:N110 R:R:R109 7.23 1 Yes Yes 6 5 1 1
R:R:F134 R:R:R109 25.66 1 Yes Yes 5 5 1 1
R:R:N110 R:R:N135 5.45 1 Yes Yes 6 8 1 1
R:R:F130 R:R:G132 4.52 1 Yes No 6 5 1 2
R:R:F130 R:R:F134 3.22 1 Yes Yes 6 5 1 1
R:R:F130 R:R:I155 5.02 1 Yes No 6 5 1 1
R:R:E157 R:R:F130 7 1 Yes Yes 8 6 1 1
R:R:F134 R:R:G132 4.52 1 Yes No 5 5 1 2
R:R:E157 R:R:F134 10.49 1 Yes Yes 8 5 1 1
R:R:F134 R:R:T159 7.78 1 Yes No 5 5 1 2
R:R:D160 R:R:N135 8.08 1 Yes Yes 8 8 1 1
R:R:E178 R:R:I152 6.83 0 No No 5 3 2 1
R:R:I155 R:R:K183 2.91 1 No Yes 5 6 1 2
R:R:E157 R:R:K183 9.45 1 Yes Yes 8 6 1 2
R:R:D160 R:R:T159 10.12 1 Yes No 8 5 1 2
R:R:T159 R:R:Y185 11.24 0 No Yes 5 7 2 1
R:R:D160 R:R:N186 6.73 1 Yes No 8 7 1 2
R:R:P162 R:R:Y163 6.95 0 No No 7 4 1 2
R:R:K183 R:R:Y185 3.58 0 Yes Yes 6 7 2 1
R:R:K183 R:R:Y206 5.97 0 Yes Yes 6 6 2 2
R:R:N208 R:R:Y185 8.14 1 Yes Yes 5 7 2 1
R:R:K209 R:R:N186 5.6 0 Yes No 7 7 1 2
R:R:D203 R:R:S229 2.94 0 Yes No 6 5 1 2
R:R:A204 R:R:Y206 4 1 No Yes 5 6 1 2
R:R:A204 R:R:L230 3.15 1 No Yes 5 4 1 1
R:R:N208 R:R:Y206 3.49 1 Yes Yes 5 6 2 2
R:R:L230 R:R:Y206 7.03 1 Yes Yes 4 6 1 2
R:R:K209 R:R:N208 8.39 0 Yes Yes 7 5 1 2
R:R:K209 R:R:Q235 6.78 0 Yes No 7 4 1 2
R:R:E251 R:R:L230 9.28 1 No Yes 5 4 1 1
R:R:E251 R:R:R274 9.3 1 No No 5 3 1 1
R:R:D276 R:R:R274 9.53 1 Yes No 4 3 2 1
R:R:E297 R:R:R293 3.49 1 Yes No 5 4 1 2
R:R:I295 R:R:L299 7.14 0 No No 3 3 2 1
R:R:C301 R:R:M300 4.86 0 No Yes 7 3 2 1
R:R:I389 R:R:M300 4.37 0 No Yes 4 3 2 1
R:R:H384 R:R:T388 6.85 0 No No 3 4 2 1
R:R:D386 R:R:Y385 4.6 1 No Yes 5 4 1 1
R:R:I389 R:R:Y385 12.09 0 No Yes 4 4 2 1
R:R:D203 R:R:T179 2.89 0 Yes No 6 5 1 2
R:R:D203 R:R:T181 2.89 0 Yes No 6 7 1 2
R:R:K209 R:R:K211 2.87 0 Yes No 7 3 1 2
R:R:D43 R:R:K42 2.77 0 No No 4 2 2 1
M:M:D50 R:R:F381 2.39 0 No No 0 4 0 1
R:R:D36 R:R:R38 2.38 0 No Yes 3 4 2 1
L:L:G72 R:R:L299 1.71 0 No No 0 3 0 1
M:M:F41 R:R:G294 1.51 0 Yes No 0 5 0 1
R:R:I295 R:R:L296 1.43 0 No No 3 4 2 1
L:L:M71 R:R:L299 1.41 0 No No 0 3 0 1
R:R:E376 R:R:T377 1.41 0 No No 4 3 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D403 R:R:F405 8.36 0 No Yes 8 8 2 1
R:R:E404 W:W:?1 5.7 0 No Yes 7 0 1 0
R:R:F405 R:R:K565 19.85 2 Yes No 8 7 1 2
R:R:F405 R:R:V566 5.24 2 Yes Yes 8 9 1 2
R:R:F405 R:R:M572 6.22 2 Yes Yes 8 9 1 1
R:R:F405 W:W:?1 14.85 2 Yes Yes 8 0 1 0
R:R:M463 R:R:T501 3.01 2 Yes Yes 9 9 2 2
R:R:M463 R:R:Y667 8.38 2 Yes Yes 9 9 2 1
R:R:L570 R:R:T501 4.42 0 Yes Yes 9 9 1 2
R:R:T501 R:R:Y667 6.24 2 Yes Yes 9 9 2 1
R:R:S505 R:R:Y667 7.63 0 No Yes 9 9 2 1
R:R:I568 R:R:V566 6.14 2 Yes Yes 9 9 2 2
R:R:M572 R:R:V566 9.13 2 Yes Yes 9 9 1 2
R:R:I568 R:R:L570 5.71 2 Yes Yes 9 9 2 1
R:R:I568 R:R:M572 2.92 2 Yes Yes 9 9 2 1
R:R:I568 R:R:L663 5.71 2 Yes No 9 9 2 2
R:R:L570 R:R:P571 3.28 0 Yes Yes 9 9 1 2
R:R:L570 W:W:?1 4.96 0 Yes Yes 9 0 1 0
R:R:I583 R:R:P571 3.39 0 No Yes 7 9 2 2
R:R:M572 W:W:?1 8.11 2 Yes Yes 9 0 1 0
R:R:I583 R:R:T574 3.04 0 No No 7 6 2 1
R:R:T574 W:W:?1 9.51 0 No Yes 6 0 1 0
R:R:A644 R:R:L587 3.15 0 No No 9 8 1 2
R:R:I640 R:R:Y667 4.84 2 No Yes 9 9 1 1
R:R:I640 W:W:?1 3.07 2 No Yes 9 0 1 0
R:R:I654 R:R:Y643 9.67 2 Yes Yes 9 8 1 2
R:R:A644 W:W:?1 4.52 0 No Yes 9 0 1 0
R:R:A647 R:R:P652 3.74 2 No No 9 9 1 1
R:R:A647 W:W:?1 4.52 2 No Yes 9 0 1 0
R:R:I648 W:W:?1 5.12 0 No Yes 6 0 1 0
R:R:P652 W:W:?1 8.24 2 No Yes 9 0 1 0
R:R:I654 R:R:N658 5.66 2 Yes No 9 8 1 2
R:R:I654 R:R:S659 4.64 2 Yes No 9 9 1 1
R:R:I654 W:W:?1 3.07 2 Yes Yes 9 0 1 0
R:R:S659 W:W:?1 4.31 2 No Yes 9 0 1 0
R:R:L663 R:R:Y667 3.52 0 No Yes 9 9 2 1
R:R:Y667 W:W:?1 5.04 2 Yes Yes 9 0 1 0
R:R:K651 R:R:P652 1.67 0 No No 4 9 2 1
R:R:I648 R:R:V584 1.54 0 No No 6 5 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7UTZ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.9
Number of Linked Nodes 761
Number of Links 954
Number of Hubs 160
Number of Links mediated by Hubs 553
Number of Communities 26
Number of Nodes involved in Communities 226
Number of Links involved in Communities 311
Path Summary
Number Of Nodes in MetaPath 78
Number Of Links MetaPath 77
Number of Shortest Paths 2534347
Length Of Smallest Path 3
Average Path Length 37.24
Length of Longest Path 71
Minimum Path Strength 1.315
Average Path Strength 5.86419
Maximum Path Strength 18.075
Minimum Path Correlation 0.7
Average Path Correlation 0.988797
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.43902
Average % Of Corr. Nodes 46.2167
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 49.9182
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• regulation of biological process   • cell population proliferation   • regulation of cellular process   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • biological regulation   • positive regulation of biological process   • cellular process   • positive regulation of cellular process   • multicellular organismal process   • system process   • gonadotropin secretion   • transport   • signaling   • hormone secretion   • cell communication   • localization   • secretion by cell   • signal release   • regulation of biological quality   • secretion   • regulation of hormone levels   • follicle-stimulating hormone secretion   • cell-cell signaling   • export from cell   • establishment of localization   • endocrine hormone secretion   • endocrine process   • hormone transport   • phenol-containing compound metabolic process   • modified amino acid metabolic process   • metabolic process   • hormone metabolic process   • thyroid hormone generation   • thyroid hormone metabolic process   • developmental process   • developmental growth   • growth   • organ growth   • multicellular organism development   • thyroid gland development   • endocrine system development   • gland development   • animal organ development   • anatomical structure development   • system development   • positive regulation of locomotion   • regulation of cell motility   • positive regulation of cell migration   • regulation of locomotion   • positive regulation of cell motility   • regulation of cell migration   • cell migration   • cell motility   • locomotion   • cellular response to stimulus   • response to stimulus   • response to endogenous stimulus   • hormone-mediated signaling pathway   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • signal transduction   • cellular response to hormone stimulus   • regulation of signaling   • regulation of signaling receptor activity   • regulation of signal transduction   • regulation of molecular function   • regulation of response to stimulus   • regulation of cell communication   • regulation of steroid biosynthetic process   • steroid metabolic process   • regulation of lipid metabolic process   • lipid biosynthetic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • steroid biosynthetic process   • regulation of biosynthetic process   • regulation of steroid metabolic process   • primary metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • positive regulation of lipid biosynthetic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • regulation of metabolic process   • lipid metabolic process   • G protein-coupled receptor signaling pathway   • regulation of growth   • regulation of developmental growth   • regulation of developmental process   • negative regulation of developmental process   • negative regulation of biological process   • negative regulation of organ growth   • negative regulation of developmental growth   • negative regulation of growth   • regulation of organ growth   • regulation of multicellular organismal process   • negative regulation of multicellular organismal process   • luteinizing hormone secretion   • ovulation cycle process   • reproductive process   • sex differentiation   • development of primary female sexual characteristics   • developmental process involved in reproduction   • ovulation cycle   • development of primary sexual characteristics   • reproductive structure development   • ovarian follicle development   • rhythmic process   • gonad development   • reproductive system development   • female gonad development   • multicellular organismal reproductive process   • female sex differentiation   • follicle-stimulating hormone signaling pathway   • positive regulation of DNA-templated transcription   • RNA metabolic process   • positive regulation of macromolecule biosynthetic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • nucleic acid biosynthetic process   • DNA-templated transcription   • regulation of RNA metabolic process   • transcription by RNA polymerase II   • positive regulation of macromolecule metabolic process   • regulation of nucleobase-containing compound metabolic process   • regulation of RNA biosynthetic process   • regulation of transcription by RNA polymerase II   • positive regulation of nucleobase-containing compound metabolic process   • regulation of macromolecule metabolic process   • positive regulation of transcription by RNA polymerase II   • nucleobase-containing compound biosynthetic process   • gene expression   • macromolecule biosynthetic process   • nucleic acid metabolic process   • positive regulation of RNA metabolic process   • regulation of gene expression   • positive regulation of RNA biosynthetic process   • regulation of macromolecule biosynthetic process   • macromolecule metabolic process   • regulation of DNA-templated transcription   • membrane-bounded organelle   • intracellular anatomical structure   • Golgi apparatus   • membrane-enclosed lumen   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle lumen   • Golgi lumen   • intracellular organelle   • cellular anatomical structure   • organelle lumen   • organelle   • cytoplasm   • protein-containing complex
Gene OntologyCellular Component• membrane-bounded organelle   • intracellular anatomical structure   • Golgi apparatus   • membrane-enclosed lumen   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle lumen   • Golgi lumen   • intracellular organelle   • cellular anatomical structure   • organelle lumen   • organelle   • cytoplasm   • protein-containing complex   • extracellular region   • pituitary gonadotropin complex   • extracellular space   • follicle-stimulating hormone complex   • molecular transducer activity   • binding   • molecular function activator activity   • signaling receptor binding   • signaling receptor activity   • signaling receptor activator activity   • hormone activity   • protein binding   • molecular function regulator activity   • signaling receptor regulator activity   • receptor ligand activity   • response to stimulus   • response to hormone   • response to endogenous stimulus   • response to chemical   • response to estrogen   • response to metal ion   • response to calcium ion   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • signaling   • biological regulation   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • cell communication   • cell-cell signaling   • response to nutrient levels   • response to lipid   • response to nutrient   • response to vitamin A   • response to vitamin   • developmental process   • anatomical structure morphogenesis   • anatomical structure development   • protein-hormone receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • thyroid-stimulating hormone receptor activity   • protein-containing complex binding   • peptide receptor activity   • G protein-coupled peptide receptor activity   • cellular response to nitrogen compound   • response to peptide hormone   • response to oxygen-containing compound   • cellular response to peptide hormone stimulus   • response to nitrogen compound   • cellular response to thyrotropin-releasing hormone   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to thyrotropin-releasing hormone   • cellular response to hormone stimulus   • hormone-mediated signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to glycoprotein   • cellular response to glycoprotein   • cell population proliferation   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • positive regulation of biological process   • positive regulation of cellular process   • multicellular organismal process   • homeostatic process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • cell surface receptor signaling pathway   • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger   • thyroid-stimulating hormone signaling pathway   • cell surface   • cell periphery   • plasma membrane   • membrane   • basal part of cell   • basal plasma membrane   • plasma membrane region   • basolateral plasma membrane   • receptor complex   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • response to glucagon   • cellular response to glucagon stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • vesicle   • extracellular membrane-bounded organelle   • cytosol   • Golgi apparatus subcompartment   • organelle subcompartment   • trans-Golgi network membrane   • trans-Golgi network   • organelle membrane   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• Cystine-knot cytokines   • L domain-like   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Cystine-knot cytokines   • L domain-like   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeZ41
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeZ41
Name(2S)-3-hydroxypropane-1,2-diyl dihexadecanoate
Synonyms
Identifier
FormulaC35 H68 O5
Molecular Weight568.911
SMILES
PubChem644078
Formal Charge0
Total Atoms108
Total Chiral Atoms1
Total Bonds107
Total Aromatic Bonds0



This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XW5AProteinGlycoprotein HormoneTSHHomo sapiensTSHML109Gs/β1/γ22.962022-08-2410.1038/s41586-022-05173-3
7XW5 (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensTSHML1092.962022-08-2410.1038/s41586-022-05173-3
7XW7AProteinGlycoprotein HormoneTSHHomo sapiensK1-70--5.52022-08-1710.1038/s41586-022-05173-3
7XW6AProteinGlycoprotein HormoneTSHHomo sapiensM22 FabML109Gs/β1/γ22.782022-08-1710.1038/s41586-022-05173-3
7XW6 (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensM22 FabML1092.782022-08-1710.1038/s41586-022-05173-3
7T9MAProteinGlycoprotein HormoneTSHHomo sapiens-CS-17 Antibody-3.12022-08-1010.1038/s41586-022-05159-1
7UTZAProteinGlycoprotein HormoneTSHHomo sapiensTR1402PubChem 644078Gs/β1/γ22.42022-08-0310.1038/s41586-022-05159-1
7UTZ (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensTR1402PubChem 6440782.42022-08-0310.1038/s41586-022-05159-1
7T9NAProteinGlycoprotein HormoneTSHHomo sapiensM22 FabPubChem 644078Gs/β1/γ22.92022-08-0310.1038/s41586-022-05159-1
7T9N (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensM22 FabPubChem 6440782.92022-08-0310.1038/s41586-022-05159-1
7T9IAProteinGlycoprotein HormoneTSHHomo sapiensTSH-Gs/β1/γ22.92022-08-0310.1038/s41586-022-05159-1
7T9I (No Gprot) AProteinGlycoprotein HormoneTSHHomo sapiensTSH-2.92022-08-0310.1038/s41586-022-05159-1




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