psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C31	L:L:C7	7.28	No	No	14	0	0
2	L:L:C7	M:M:Y30	6.72	No	No	0	0	0
3	L:L:E9	L:L:T11	9.88	No	No	0	0	0
4	L:L:C10	L:L:C60	7.28	No	No	0	0	0
5	L:L:C10	L:L:C84	3.64	No	No	0	0	0
6	L:L:L12	L:L:L26	8.3	No	No	0	0	0
7	L:L:C82	L:L:L12	4.76	No	No	0	0	0
8	L:L:M29	L:L:Q13	10.88	No	No	0	0	0
9	L:L:N15	L:L:P16	8.15	Yes	No	3	0	0
10	L:L:F17	L:L:N15	3.62	Yes	Yes	3	0	0
11	L:L:N15	L:L:Q27	7.92	Yes	Yes	3	0	0
12	L:L:N15	M:M:N37	4.09	Yes	No	3	0	0
13	L:L:F17	L:L:P16	5.78	Yes	No	3	0	0
14	L:L:F17	L:L:F18	3.22	Yes	Yes	3	0	0
15	L:L:F17	R:R:M300	7.46	Yes	No	3	0	3
16	L:L:F17	R:R:D386	5.97	Yes	No	0	0	5
17	L:L:F18	L:L:V76	15.73	Yes	Yes	0	0	0
18	L:L:F18	R:R:L296	6.09	Yes	Yes	3	0	4
19	L:L:F18	R:R:M300	6.22	Yes	No	3	0	3
20	L:L:I25	L:L:S19	3.1	No	No	0	0	0
21	L:L:P21	L:L:Q20	3.16	No	No	0	0	0
22	L:L:A23	L:L:Q20	3.03	No	No	0	0	0
23	L:L:I25	L:L:V76	4.61	No	Yes	0	0	0
24	L:L:L26	L:L:N78	4.12	No	No	0	0	0
25	L:L:H79	L:L:Q27	7.42	Yes	Yes	3	0	0
26	L:L:Q27	M:M:D35	5.22	Yes	No	0	0	0
27	L:L:Q27	M:M:N37	11.88	Yes	No	3	0	0
28	L:L:C28	L:L:C82	7.28	No	No	0	0	0
29	L:L:C28	M:M:D35	7.78	No	No	0	0	0
30	L:L:M29	M:M:R34	6.2	No	No	0	0	0
31	L:L:C31	M:M:M32	3.24	No	No	0	0	0
32	L:L:C32	L:L:T58	5.07	No	No	15	0	0
33	L:L:C32	L:L:C84	7.28	No	No	15	0	0
34	L:L:F33	L:L:R35	5.34	No	No	0	0	0
35	L:L:F33	M:M:Y30	6.19	No	No	0	0	0
36	L:L:S34	L:L:S57	4.89	No	No	0	0	0
37	L:L:R35	L:L:Y37	8.23	No	No	0	0	0
38	L:L:E56	L:L:R35	3.49	No	No	0	0	0
39	L:L:T54	L:L:Y37	8.74	No	No	0	0	0
40	L:L:Y37	M:M:I26	4.84	No	Yes	0	0	0
41	L:L:P38	M:M:M9	3.35	No	Yes	0	0	0
42	L:L:P38	M:M:I26	3.39	No	Yes	0	0	0
43	L:L:P40	L:L:T39	3.5	No	Yes	10	0	0
44	L:L:S43	L:L:T39	4.8	No	Yes	10	0	0
45	L:L:M47	L:L:T39	3.01	No	Yes	0	0	0
46	L:L:T39	L:L:T54	6.28	Yes	No	0	0	0
47	L:L:P40	L:L:S43	7.13	No	No	10	0	0
48	L:L:P40	M:M:T102	5.25	No	Yes	10	0	0
49	L:L:L41	M:M:R13	7.29	No	Yes	4	0	0
50	L:L:L41	M:M:F75	8.53	No	No	4	0	0
51	L:L:K45	L:L:R42	3.71	No	No	0	0	0
52	L:L:R42	M:M:E12	8.14	No	Yes	0	0	0
53	L:L:R42	M:M:Y104	8.23	No	No	0	0	0
54	L:L:S43	M:M:T102	3.2	No	Yes	10	0	0
55	L:L:K44	L:L:Q50	9.49	No	No	0	0	0
56	L:L:K44	L:L:N52	4.2	No	No	0	0	0
57	L:L:K45	L:L:T46	4.5	No	No	0	0	0
58	L:L:T46	R:R:I85	3.04	No	No	0	0	6
59	L:L:T46	R:R:V87	3.17	No	No	0	0	4
60	L:L:M47	M:M:D94	5.54	No	No	0	0	0
61	L:L:L48	R:R:N135	4.12	No	Yes	0	0	8
62	L:L:L48	R:R:P162	3.28	No	No	0	0	7
63	L:L:K51	L:L:V49	6.07	No	No	11	0	0
64	L:L:V49	R:R:N135	5.91	No	Yes	11	0	8
65	L:L:V49	R:R:D160	2.92	No	Yes	11	0	8
66	L:L:K51	M:M:D94	4.15	No	No	0	0	0
67	L:L:K51	R:R:D160	4.15	No	Yes	11	0	8
68	L:L:N52	M:M:Y59	5.81	No	No	0	0	0
69	L:L:N52	M:M:P78	3.26	No	No	0	0	0
70	L:L:V53	M:M:Y54	15.14	No	Yes	0	0	0
71	L:L:V53	M:M:Y92	3.79	No	Yes	18	0	0
72	L:L:V53	M:M:S93	6.46	No	No	18	0	0
73	L:L:T54	M:M:I96	3.04	No	No	0	0	0
74	L:L:S55	M:M:C88	3.44	No	No	0	0	0
75	L:L:E56	M:M:A99	4.53	No	No	0	0	0
76	L:L:C87	L:L:S57	3.44	No	No	0	0	0
77	L:L:S57	M:M:V51	6.46	No	No	0	0	0
78	L:L:C84	L:L:T58	5.07	No	No	15	0	0
79	L:L:T58	M:M:H97	4.11	No	No	0	0	0
80	L:L:C59	L:L:C87	7.28	Yes	No	0	0	0
81	L:L:C59	M:M:T33	8.45	Yes	No	19	0	0
82	L:L:C59	M:M:Q49	6.1	Yes	Yes	19	0	0
83	L:L:H83	L:L:V61	4.15	No	No	0	0	0
84	L:L:A62	L:L:H79	5.85	No	Yes	0	0	0
85	L:L:H83	L:L:K63	26.2	No	No	0	0	0
86	L:L:S64	L:L:T80	6.4	No	No	0	0	0
87	L:L:R67	L:L:Y65	12.35	No	No	0	0	0
88	L:L:E77	L:L:Y65	19.08	No	No	0	0	0
89	L:L:N66	L:L:V68	4.43	No	No	16	0	0
90	L:L:N66	L:L:N78	8.17	No	No	16	0	0
91	L:L:N66	L:L:T80	8.77	No	No	0	0	0
92	L:L:R67	R:R:I152	12.53	No	No	0	0	3
93	L:L:R67	R:R:F153	3.21	No	No	0	0	5
94	L:L:N78	L:L:V68	4.43	No	No	16	0	0
95	L:L:K75	L:L:T69	15.02	No	No	0	0	0
96	L:L:V70	L:L:V76	4.81	No	Yes	0	0	0
97	L:L:G72	L:L:M71	3.49	No	No	0	0	0
98	L:L:F74	L:L:V76	7.87	Yes	Yes	0	0	0
99	L:L:F74	M:M:L40	6.09	Yes	No	0	0	0
100	L:L:F74	R:R:L296	3.65	Yes	Yes	0	0	4
101	L:L:E77	L:L:H79	13.54	No	Yes	0	0	0
102	L:L:H79	M:M:N37	11.48	Yes	No	3	0	0
103	L:L:H83	L:L:S85	8.37	No	No	0	0	0
104	L:L:T86	L:L:Y88	8.74	Yes	Yes	2	0	0
105	L:L:T86	M:M:H97	16.43	Yes	No	0	0	0
106	L:L:T86	R:R:R80	5.17	Yes	Yes	2	0	4
107	L:L:T86	R:R:H105	4.11	Yes	Yes	2	0	7
108	L:L:C87	L:L:H90	7.37	No	Yes	0	0	0
109	L:L:Y88	L:L:Y89	3.97	Yes	Yes	0	0	0
110	L:L:Y88	R:R:H105	7.62	Yes	Yes	2	0	7
111	L:L:Y88	R:R:F130	7.22	Yes	Yes	2	0	6
112	L:L:Y88	R:R:I155	3.63	Yes	No	2	0	5
113	L:L:Y89	M:M:K39	4.78	Yes	Yes	0	0	0
114	L:L:Y89	M:M:L47	3.52	Yes	No	0	0	0
115	L:L:Y89	M:M:Q49	12.4	Yes	Yes	0	0	0
116	L:L:H90	L:L:K91	11.79	Yes	Yes	0	0	0
117	L:L:H90	M:M:Q49	3.71	Yes	Yes	0	0	0
118	L:L:H90	M:M:V51	5.54	Yes	No	0	0	0
119	L:L:K91	M:M:C95	4.85	Yes	No	0	0	0
120	L:L:K91	R:R:R109	3.71	Yes	Yes	0	0	5
121	L:L:K91	R:R:E157	5.4	Yes	Yes	0	0	8
122	L:L:S92	M:M:K87	6.12	No	No	0	0	0
123	M:M:C2	M:M:C52	7.28	Yes	No	7	0	0
124	M:M:I3	M:M:P4	3.39	No	No	0	0	0
125	M:M:I26	M:M:T5	3.04	Yes	No	0	0	0
126	M:M:A28	M:M:T5	3.36	No	No	0	0	0
127	M:M:M9	M:M:Y7	5.99	Yes	Yes	6	0	0
128	M:M:T24	M:M:Y7	3.75	Yes	Yes	6	0	0
129	M:M:I26	M:M:Y7	13.3	Yes	Yes	0	0	0
130	M:M:N103	M:M:Y7	11.63	No	Yes	0	0	0
131	M:M:N23	M:M:T8	7.31	No	No	0	0	0
132	M:M:I11	M:M:M9	2.92	No	Yes	0	0	0
133	M:M:M9	M:M:T24	3.01	Yes	Yes	6	0	0
134	M:M:M9	M:M:Y77	8.38	Yes	Yes	6	0	0
135	M:M:H10	M:M:T21	4.11	No	No	0	0	0
136	M:M:H10	M:M:N103	5.1	No	No	0	0	0
137	M:M:C105	M:M:H10	7.37	No	No	0	0	0
138	M:M:I11	M:M:L20	4.28	No	No	0	0	0
139	M:M:I11	M:M:I64	4.42	No	Yes	0	0	0
140	M:M:C19	M:M:E12	3.04	No	Yes	17	0	0
141	M:M:C105	M:M:E12	6.08	No	Yes	17	0	0
142	M:M:E12	M:M:T106	5.64	Yes	No	0	0	0
143	M:M:E12	M:M:K107	18.9	Yes	No	0	0	0
144	M:M:E15	M:M:R13	3.49	Yes	Yes	4	0	0
145	M:M:C16	M:M:R13	5.57	No	Yes	4	0	0
146	M:M:I64	M:M:R13	5.01	Yes	Yes	0	0	0
147	M:M:F75	M:M:R13	3.21	No	Yes	4	0	0
148	M:M:C16	M:M:E15	9.12	No	Yes	4	0	0
149	M:M:E15	M:M:P68	3.14	Yes	No	4	0	0
150	M:M:E15	M:M:H70	13.54	Yes	No	4	0	0
151	M:M:E15	M:M:V71	11.41	Yes	No	4	0	0
152	M:M:C16	M:M:C67	7.28	No	No	0	0	0
153	M:M:P65	M:M:Y18	4.17	No	No	0	0	0
154	M:M:G66	M:M:Y18	5.79	No	No	0	0	0
155	M:M:C105	M:M:C19	7.28	No	No	17	0	0
156	M:M:C19	M:M:Q109	6.1	No	No	0	0	0
157	M:M:L20	M:M:V62	2.98	No	No	0	0	0
158	M:M:L20	M:M:P65	4.93	No	No	0	0	0
159	M:M:Q109	M:M:T21	8.5	No	No	0	0	0
160	M:M:I22	M:M:R60	5.01	No	Yes	6	0	0
161	M:M:I22	M:M:Y77	4.84	No	Yes	6	0	0
162	M:M:T24	M:M:Y77	6.24	Yes	Yes	6	0	0
163	M:M:T24	M:M:V79	3.17	Yes	Yes	6	0	0
164	M:M:C27	M:M:Y54	4.03	Yes	Yes	0	0	0
165	M:M:C27	M:M:C83	7.28	Yes	No	7	0	0
166	M:M:C31	M:M:C85	7.28	No	No	7	0	0
167	M:M:M32	R:R:F381	7.46	No	No	0	0	4
168	M:M:Q49	M:M:T33	5.67	Yes	No	19	0	0
169	M:M:R34	R:R:Y385	5.14	No	No	0	0	4
170	M:M:D35	M:M:K39	4.15	No	Yes	0	0	0
171	M:M:I36	M:M:K39	2.91	No	Yes	0	0	0
172	M:M:I36	M:M:L47	4.28	No	No	0	0	0
173	M:M:K39	R:R:F153	4.96	Yes	No	0	0	5
174	M:M:F41	R:R:L296	4.87	No	Yes	0	0	4
175	M:M:F41	R:R:E297	7	No	No	0	0	5
176	M:M:L42	M:M:P43	4.93	No	No	0	0	0
177	M:M:L42	R:R:E297	3.98	No	No	0	0	5
178	M:M:P43	R:R:E251	4.72	No	No	0	0	5
179	M:M:K44	R:R:D203	11.06	Yes	No	0	0	6
180	M:M:K44	R:R:A204	6.42	Yes	No	0	0	5
181	M:M:K44	R:R:S229	3.06	Yes	No	0	0	5
182	M:M:K44	R:R:L230	5.64	Yes	No	0	0	4
183	M:M:Y45	R:R:I253	6.04	No	Yes	5	0	4
184	M:M:Y45	R:R:R274	3.09	No	No	5	0	3
185	M:M:Y45	R:R:D276	3.45	No	Yes	5	0	4
186	M:M:D50	M:M:G86	5.03	No	No	0	0	0
187	M:M:K84	M:M:T53	3	No	No	0	0	0
188	M:M:F57	M:M:Y54	7.22	Yes	Yes	0	0	0
189	M:M:A80	M:M:Y54	4	No	Yes	0	0	0
190	M:M:R55	M:M:S82	9.22	No	No	0	0	0
191	M:M:K84	M:M:R55	13.61	No	No	0	0	0
192	M:M:D56	M:M:L81	10.86	No	No	0	0	0
193	M:M:D56	M:M:S82	2.94	No	No	0	0	0
194	M:M:F57	M:M:Y59	6.19	Yes	No	0	0	0
195	M:M:F57	M:M:P78	5.78	Yes	No	0	0	0
196	M:M:F57	M:M:Y92	8.25	Yes	Yes	0	0	0
197	M:M:R60	M:M:V62	3.92	Yes	No	0	0	0
198	M:M:R60	M:M:Y77	17.49	Yes	Yes	6	0	0
199	M:M:R60	M:M:V79	3.92	Yes	Yes	6	0	0
200	M:M:S76	M:M:T61	7.99	No	No	0	0	0
201	M:M:E63	M:M:P73	9.43	No	Yes	20	0	0
202	M:M:E63	M:M:Y74	6.73	No	No	20	0	0
203	M:M:I64	M:M:P65	3.39	Yes	No	0	0	0
204	M:M:C67	M:M:I64	3.27	No	Yes	0	0	0
205	M:M:C67	M:M:P73	3.77	No	Yes	0	0	0
206	M:M:H70	M:M:P68	6.1	No	No	4	0	0
207	M:M:H70	M:M:V71	12.45	No	No	4	0	0
208	M:M:P73	M:M:Y74	4.17	Yes	No	20	0	0
209	M:M:P78	M:M:Y77	4.17	No	Yes	0	0	0
210	M:M:V79	M:M:Y77	3.79	Yes	Yes	6	0	0
211	M:M:G86	M:M:K84	5.23	No	No	0	0	0
212	M:M:C88	M:M:C95	7.28	No	No	0	0	0
213	M:M:D91	M:M:N89	10.77	No	No	0	0	0
214	M:M:N89	M:M:Y92	16.28	No	Yes	0	0	0
215	M:M:D91	R:R:K209	6.91	No	Yes	0	0	7
216	M:M:S93	M:M:Y92	6.36	No	Yes	18	0	0
217	M:M:D94	M:M:I96	7	No	No	0	0	0
218	M:M:I96	R:R:R109	6.26	No	Yes	0	0	5
219	M:M:E98	R:R:K58	9.45	No	Yes	2	0	5
220	M:M:E98	R:R:Y82	7.86	No	Yes	2	0	4
221	M:M:E98	R:R:E107	3.81	No	Yes	2	0	6
222	M:M:I100	M:M:T102	3.04	No	Yes	0	0	0
223	M:M:I100	R:R:I60	5.89	No	Yes	0	0	4
224	M:M:T102	R:R:E61	5.64	Yes	No	0	0	5
225	M:M:K107	M:M:P108	3.35	No	No	0	0	0
226	R:R:G23	R:R:M22	3.49	No	No	0	1	2
227	R:R:M22	R:R:P52	5.03	No	No	0	2	3
228	R:R:M22	R:R:S53	3.07	No	No	0	2	5
229	R:R:C24	R:R:C31	7.28	No	No	21	9	8
230	R:R:S25	R:R:S26	4.89	No	No	0	7	8
231	R:R:P51	R:R:S25	7.13	Yes	No	0	5	7
232	R:R:P27	R:R:S26	3.56	No	No	0	3	8
233	R:R:I44	R:R:P28	3.39	Yes	No	0	5	2
234	R:R:C29	R:R:C41	7.28	No	No	0	9	9
235	R:R:C29	R:R:P48	3.77	No	Yes	22	9	9
236	R:R:C29	R:R:L50	3.17	No	Yes	22	9	5
237	R:R:E34	R:R:H32	6.15	No	Yes	2	4	5
238	R:R:H32	R:R:R38	3.39	Yes	Yes	2	5	4
239	R:R:H32	R:R:T40	6.85	Yes	Yes	2	5	8
240	R:R:E34	R:R:R38	9.3	No	Yes	2	4	4
241	R:R:F37	R:R:Q55	7.03	No	No	0	1	4
242	R:R:R38	R:R:T56	5.17	Yes	No	0	4	5
243	R:R:L50	R:R:V39	2.98	Yes	No	0	5	6
244	R:R:T54	R:R:V39	4.76	No	No	0	7	6
245	R:R:L57	R:R:V39	2.98	No	No	0	7	6
246	R:R:K42	R:R:T40	3	No	Yes	0	2	8
247	R:R:K58	R:R:T40	7.51	Yes	Yes	2	5	8
248	R:R:I60	R:R:T40	3.04	Yes	Yes	2	4	8
249	R:R:C41	R:R:I44	4.91	No	Yes	0	9	5
250	R:R:C41	R:R:L59	3.17	No	Yes	0	9	6
251	R:R:D43	R:R:H63	7.56	No	No	0	4	4
252	R:R:I44	R:R:T62	4.56	Yes	Yes	12	5	7
253	R:R:I44	R:R:L64	4.28	Yes	Yes	12	5	6
254	R:R:H63	R:R:Q45	6.18	No	No	0	4	4
255	R:R:I47	R:R:P48	3.39	No	Yes	0	4	9
256	R:R:I47	R:R:L64	4.28	No	Yes	0	4	6
257	R:R:L50	R:R:P48	3.28	Yes	Yes	22	5	9
258	R:R:L50	R:R:P51	4.93	Yes	Yes	0	5	5
259	R:R:P51	R:R:T54	5.25	Yes	No	0	5	7
260	R:R:L75	R:R:T54	5.9	No	No	0	6	7
261	R:R:N77	R:R:Q55	6.6	No	No	0	8	4
262	R:R:R80	R:R:T56	6.47	Yes	No	0	4	5
263	R:R:L57	R:R:L59	4.15	No	Yes	0	7	6
264	R:R:F72	R:R:L57	4.87	Yes	No	0	9	7
265	R:R:I60	R:R:K58	4.36	Yes	Yes	2	4	5
266	R:R:K58	R:R:Y82	9.55	Yes	Yes	2	5	4
267	R:R:L59	R:R:T62	2.95	Yes	Yes	0	6	7
268	R:R:L59	R:R:V83	4.47	Yes	No	0	6	6
269	R:R:I60	R:R:S84	7.74	Yes	No	0	4	7
270	R:R:E61	R:R:I85	5.47	No	No	0	5	6
271	R:R:L64	R:R:T62	7.37	Yes	Yes	12	6	7
272	R:R:D86	R:R:T62	8.67	Yes	Yes	12	8	7
273	R:R:D86	R:R:L64	5.43	Yes	Yes	12	8	6
274	R:R:R65	R:R:T88	5.17	No	No	0	4	4
275	R:R:Q90	R:R:R65	14.02	No	No	0	4	4
276	R:R:Q91	R:R:T66	7.09	Yes	No	23	3	5
277	R:R:E93	R:R:T66	5.64	No	No	23	6	5
278	R:R:I67	R:R:P68	3.39	No	No	0	5	5
279	R:R:I67	R:R:S96	4.64	No	No	0	5	7
280	R:R:A71	R:R:P68	3.74	No	No	0	8	5
281	R:R:E93	R:R:S69	4.31	No	No	0	6	4
282	R:R:H70	R:R:S73	5.58	Yes	No	0	4	4
283	R:R:H70	R:R:H95	8.36	Yes	No	24	4	5
284	R:R:H70	R:R:Y98	4.36	Yes	Yes	24	4	2
285	R:R:A71	R:R:F72	4.16	No	Yes	0	8	9
286	R:R:F72	R:R:I81	8.79	Yes	No	0	9	8
287	R:R:F72	R:R:L100	3.65	Yes	No	0	9	8
288	R:R:N74	R:R:S73	5.96	No	No	0	4	4
289	R:R:N77	R:R:P76	6.52	No	No	0	8	5
290	R:R:I78	R:R:I81	4.42	No	No	0	7	8
291	R:R:R80	R:R:S79	5.27	Yes	No	0	4	7
292	R:R:R80	R:R:Y82	9.26	Yes	Yes	2	4	4
293	R:R:H105	R:R:R80	15.8	Yes	Yes	2	7	4
294	R:R:F97	R:R:I81	5.02	No	No	0	9	8
295	R:R:H105	R:R:Y82	8.71	Yes	Yes	2	7	4
296	R:R:E107	R:R:Y82	11.22	Yes	Yes	2	6	4
297	R:R:D86	R:R:V83	2.92	Yes	No	0	8	6
298	R:R:I108	R:R:V83	3.07	No	No	0	8	6
299	R:R:I85	R:R:S84	6.19	No	No	0	6	7
300	R:R:D86	R:R:L89	6.79	Yes	No	0	8	8
301	R:R:L114	R:R:L89	4.15	No	No	0	8	8
302	R:R:N113	R:R:Q90	6.6	No	No	0	4	4
303	R:R:E93	R:R:Q91	3.82	No	Yes	23	6	3
304	R:R:Q91	R:R:Y116	3.38	Yes	No	0	3	3
305	R:R:I117	R:R:L92	8.56	No	No	0	8	8
306	R:R:D118	R:R:S94	5.89	Yes	No	0	5	4
307	R:R:H95	R:R:Y98	11.98	No	Yes	24	5	2
308	R:R:F97	R:R:I106	8.79	No	No	0	9	7
309	R:R:N99	R:R:Y98	6.98	No	Yes	0	5	2
310	R:R:K123	R:R:Y98	3.58	No	Yes	0	4	2
311	R:R:L100	R:R:V103	5.96	No	No	0	8	5
312	R:R:K102	R:R:S101	3.06	No	No	0	4	4
313	R:R:I106	R:R:V103	3.07	No	No	0	7	5
314	R:R:L125	R:R:V103	4.47	Yes	No	0	8	5
315	R:R:E107	R:R:H105	9.85	Yes	Yes	2	6	7
316	R:R:F130	R:R:H105	12.44	Yes	Yes	2	6	7
317	R:R:E107	R:R:R109	4.65	Yes	Yes	0	6	5
318	R:R:I108	R:R:T111	3.04	No	No	0	8	5
319	R:R:N110	R:R:R109	7.23	No	Yes	0	6	5
320	R:R:F134	R:R:R109	20.31	Yes	Yes	0	5	5
321	R:R:N110	R:R:N135	5.45	No	Yes	0	6	8
322	R:R:L114	R:R:T111	7.37	No	No	1	8	5
323	R:R:T111	R:R:T136	3.14	No	Yes	1	5	9
324	R:R:L114	R:R:T136	2.95	No	Yes	1	8	9
325	R:R:D118	R:R:Y116	6.9	Yes	No	0	5	3
326	R:R:I117	R:R:L138	5.71	No	No	0	8	8
327	R:R:D118	R:R:P119	9.66	Yes	No	0	5	4
328	R:R:D118	R:R:D120	3.99	Yes	No	0	5	5
329	R:R:D143	R:R:P119	4.83	No	No	0	5	4
330	R:R:D120	R:R:K146	5.53	No	No	0	5	4
331	R:R:L122	R:R:L125	4.15	No	Yes	0	7	8
332	R:R:L125	R:R:L128	4.15	Yes	No	0	8	9
333	R:R:F154	R:R:L128	4.87	Yes	No	0	6	9
334	R:R:D151	R:R:K129	8.3	No	No	0	4	5
335	R:R:F130	R:R:G132	3.01	Yes	No	0	6	5
336	R:R:F130	R:R:I155	5.02	Yes	No	2	6	5
337	R:R:E157	R:R:F130	7	Yes	Yes	0	8	6
338	R:R:L131	R:R:L156	4.15	No	Yes	0	8	7
339	R:R:F134	R:R:G132	4.52	Yes	No	0	5	5
340	R:R:I133	R:R:T136	3.04	No	Yes	0	8	9
341	R:R:I133	R:R:P142	3.39	No	Yes	0	8	9
342	R:R:E157	R:R:F134	11.66	Yes	Yes	0	8	5
343	R:R:F134	R:R:T159	7.78	Yes	No	0	5	5
344	R:R:D160	R:R:N135	5.39	Yes	Yes	11	8	8
345	R:R:G137	R:R:T136	3.64	No	Yes	0	8	9
346	R:R:L138	R:R:T136	5.9	No	Yes	0	8	9
347	R:R:N161	R:R:T136	5.85	Yes	Yes	1	8	9
348	R:R:G137	R:R:Y163	2.9	No	No	0	8	4
349	R:R:F141	R:R:P142	11.56	Yes	Yes	0	7	9
350	R:R:F141	R:R:P168	7.22	Yes	No	0	7	6
351	R:R:F141	R:R:F172	4.29	Yes	Yes	0	7	8
352	R:R:F141	R:R:F189	4.29	Yes	Yes	0	7	8
353	R:R:L144	R:R:P142	6.57	No	Yes	0	7	9
354	R:R:I158	R:R:P142	3.39	Yes	Yes	0	7	9
355	R:R:D143	R:R:T145	7.23	No	No	25	5	4
356	R:R:D143	R:R:K146	5.53	No	No	25	5	4
357	R:R:L144	R:R:L156	4.15	No	Yes	0	7	7
358	R:R:L144	R:R:L175	5.54	No	Yes	0	7	7
359	R:R:K146	R:R:T145	3	No	No	25	4	4
360	R:R:G174	R:R:Y148	2.9	No	No	0	9	4
361	R:R:F154	R:R:S149	5.28	Yes	No	0	6	8
362	R:R:D151	R:R:F153	3.58	No	No	0	4	5
363	R:R:E178	R:R:I152	6.83	No	No	0	5	3
364	R:R:F154	R:R:L175	10.96	Yes	Yes	1	6	7
365	R:R:C176	R:R:F154	4.19	No	Yes	0	6	6
366	R:R:F154	R:R:L180	4.87	Yes	No	1	6	7
367	R:R:I158	R:R:L156	8.56	Yes	Yes	1	7	7
368	R:R:F172	R:R:L156	3.65	Yes	Yes	1	8	7
369	R:R:L156	R:R:L182	4.15	Yes	No	1	7	6
370	R:R:E157	R:R:K183	8.1	Yes	No	0	8	6
371	R:R:I158	R:R:N161	4.25	Yes	Yes	1	7	8
372	R:R:I158	R:R:M164	2.92	Yes	No	1	7	7
373	R:R:D160	R:R:T159	11.56	Yes	No	0	8	5
374	R:R:T159	R:R:Y185	11.24	No	No	0	5	7
375	R:R:D160	R:R:N186	5.39	Yes	No	0	8	7
376	R:R:M164	R:R:N161	12.62	No	Yes	1	7	8
377	R:R:N161	R:R:N187	6.81	Yes	Yes	1	8	9
378	R:R:P162	R:R:Y163	6.95	No	No	0	7	4
379	R:R:F189	R:R:M164	4.98	Yes	No	1	8	7
380	R:R:S166	R:R:S191	4.89	No	No	0	5	4
381	R:R:Q193	R:R:S166	5.78	No	No	0	5	5
382	R:R:I167	R:R:P168	3.39	No	No	0	7	6
383	R:R:F189	R:R:I167	10.05	Yes	No	0	8	7
384	R:R:I167	R:R:V192	3.07	No	No	0	7	7
385	R:R:A171	R:R:P168	3.74	No	No	0	7	6
386	R:R:N170	R:R:V169	2.96	No	No	0	8	5
387	R:R:N170	R:R:Q173	15.85	No	No	26	8	2
388	R:R:N170	R:R:N198	5.45	No	Yes	26	8	7
389	R:R:A171	R:R:F172	8.32	No	Yes	0	7	8
390	R:R:F172	R:R:L175	4.87	Yes	Yes	1	8	7
391	R:R:F172	R:R:L182	8.53	Yes	No	1	8	6
392	R:R:F172	R:R:F197	4.29	Yes	No	0	8	9
393	R:R:N198	R:R:Q173	5.28	Yes	No	26	7	2
394	R:R:L175	R:R:L180	4.15	Yes	No	1	7	7
395	R:R:E178	R:R:N177	3.94	No	No	0	5	5
396	R:R:D203	R:R:T179	4.34	No	No	0	6	5
397	R:R:L180	R:R:L182	6.92	No	No	1	7	6
398	R:R:K183	R:R:Y185	4.78	No	No	0	6	7
399	R:R:K183	R:R:Y206	5.97	No	Yes	0	6	6
400	R:R:N208	R:R:Y185	8.14	Yes	No	0	5	7
401	R:R:K209	R:R:N186	5.6	Yes	No	0	7	7
402	R:R:F189	R:R:N187	16.92	Yes	Yes	1	8	9
403	R:R:N187	R:R:N210	4.09	Yes	No	1	9	9
404	R:R:F189	R:R:N210	10.87	Yes	No	1	8	9
405	R:R:S191	R:R:T190	3.2	No	No	0	4	5
406	R:R:D217	R:R:G194	3.35	No	No	0	5	3
407	R:R:N198	R:R:Y195	5.81	Yes	No	0	7	4
408	R:R:D219	R:R:Y195	4.6	No	No	0	3	4
409	R:R:G222	R:R:Y195	2.9	No	No	0	3	4
410	R:R:F197	R:R:L202	7.31	No	No	0	9	8
411	R:R:F197	R:R:F221	7.5	No	Yes	0	9	9
412	R:R:G199	R:R:N198	3.39	No	Yes	0	7	7
413	R:R:G223	R:R:N198	3.39	No	Yes	0	7	7
414	R:R:G199	R:R:Y225	2.9	No	No	0	7	4
415	R:R:L202	R:R:T200	7.37	No	No	0	8	8
416	R:R:K201	R:R:Y225	4.78	No	No	0	4	4
417	R:R:K201	R:R:S226	4.59	No	No	0	4	4
418	R:R:L207	R:R:V205	4.47	No	No	0	7	7
419	R:R:L231	R:R:V205	2.98	Yes	No	0	7	7
420	R:R:N208	R:R:Y206	3.49	Yes	Yes	5	5	6
421	R:R:L230	R:R:Y206	4.69	No	Yes	0	4	6
422	R:R:D232	R:R:Y206	5.75	Yes	Yes	5	9	6
423	R:R:K209	R:R:N208	8.39	Yes	Yes	0	7	5
424	R:R:D232	R:R:N208	8.08	Yes	Yes	5	9	5
425	R:R:K209	R:R:Q235	5.42	Yes	No	0	7	4
426	R:R:L213	R:R:N210	5.49	No	No	1	9	9
427	R:R:L213	R:R:T236	4.42	No	No	1	9	9
428	R:R:L213	R:R:V238	2.98	No	Yes	1	9	7
429	R:R:T214	R:R:V215	4.76	No	No	0	4	2
430	R:R:I216	R:R:V238	4.61	No	Yes	0	6	7
431	R:R:I216	R:R:P242	6.77	No	Yes	0	6	9
432	R:R:K218	R:R:S243	6.12	No	No	0	4	5
433	R:R:F221	R:R:P228	7.22	Yes	No	0	9	8
434	R:R:F221	R:R:L231	3.65	Yes	Yes	0	9	7
435	R:R:F221	R:R:L246	4.87	Yes	Yes	0	9	7
436	R:R:G227	R:R:P228	4.06	No	No	0	7	8
437	R:R:L249	R:R:P228	3.28	No	No	0	8	8
438	R:R:E251	R:R:L230	7.95	No	No	0	5	4
439	R:R:L231	R:R:V233	2.98	Yes	No	0	7	7
440	R:R:D232	R:R:S234	7.36	Yes	No	5	9	9
441	R:R:D232	R:R:I253	16.79	Yes	Yes	5	9	4
442	R:R:V233	R:R:V238	3.21	No	Yes	0	7	7
443	R:R:I253	R:R:S234	4.64	Yes	No	5	4	9
444	R:R:R255	R:R:S234	3.95	No	No	0	4	9
445	R:R:N256	R:R:Q235	6.6	No	No	0	5	4
446	R:R:T236	R:R:V238	6.35	No	Yes	1	9	7
447	R:R:L241	R:R:P242	3.28	Yes	Yes	0	9	9
448	R:R:L241	R:R:L260	4.15	Yes	No	0	9	9
449	R:R:L241	R:R:P264	3.28	Yes	No	0	9	9
450	R:R:L246	R:R:P242	6.57	Yes	Yes	0	7	9
451	R:R:K244	R:R:S243	9.18	No	No	0	3	5
452	R:R:S243	R:R:S266	3.26	No	No	0	5	5
453	R:R:E247	R:R:G245	4.91	No	No	0	4	9
454	R:R:L246	R:R:L249	8.3	Yes	No	0	7	8
455	R:R:F269	R:R:L249	3.65	No	No	0	7	8
456	R:R:H271	R:R:K250	13.1	No	No	0	5	7
457	R:R:K250	R:R:T273	3	No	No	0	7	4
458	R:R:E251	R:R:R274	9.3	No	No	0	5	3
459	R:R:D276	R:R:I253	4.2	Yes	Yes	5	4	4
460	R:R:A254	R:R:T257	3.36	No	No	0	8	8
461	R:R:D276	R:R:R255	17.87	Yes	No	0	4	4
462	R:R:S278	R:R:T257	3.2	No	No	0	9	8
463	R:R:W258	R:R:Y279	8.68	No	No	0	4	9
464	R:R:K261	R:R:Y279	3.58	No	No	0	8	9
465	R:R:L263	R:R:P264	4.93	No	No	0	8	9
466	R:R:L263	R:R:L277	4.15	No	No	27	8	9
467	R:R:H282	R:R:L263	7.71	No	No	27	9	8
468	R:R:L267	R:R:S266	4.5	No	No	0	5	5
469	R:R:F269	R:R:L267	14.61	No	No	0	7	5
470	R:R:F269	R:R:F286	6.43	No	Yes	0	7	8
471	R:R:H271	R:R:L270	6.43	No	No	0	5	3
472	R:R:F286	R:R:L272	7.31	Yes	No	0	8	8
473	R:R:K291	R:R:T273	9.01	No	No	0	7	4
474	R:R:D276	R:R:R274	7.15	Yes	No	5	4	3
475	R:R:H282	R:R:L277	3.86	No	No	27	9	9
476	R:R:H282	R:R:Y279	6.53	No	No	0	9	9
477	R:R:P280	R:R:P400	3.9	No	No	0	8	9
478	R:R:I486	R:R:S281	3.1	No	No	0	8	9
479	R:R:C283	R:R:C398	7.28	No	No	0	9	9
480	R:R:C284	R:R:C408	3.64	No	No	0	9	9
481	R:R:C284	R:R:Y482	8.06	No	No	0	9	8
482	R:R:A285	R:R:F286	5.55	No	Yes	0	8	8
483	R:R:A285	R:R:Y482	5.34	No	No	0	8	8
484	R:R:F286	R:R:Q289	3.51	Yes	No	0	8	7
485	R:R:F286	R:R:M396	3.73	Yes	No	0	8	6
486	R:R:K287	R:R:N288	11.19	No	No	0	5	6
487	R:R:E394	R:R:K290	6.75	No	No	0	5	5
488	R:R:D392	R:R:K291	5.53	No	No	0	4	7
489	R:R:E297	R:R:R293	4.65	No	No	0	5	4
490	R:R:C390	R:R:R293	5.57	No	No	0	9	4
491	R:R:L296	R:R:M300	7.07	Yes	No	3	4	3
492	R:R:C301	R:R:C390	7.28	No	No	0	7	9
493	R:R:A380	R:R:H384	2.93	No	No	0	3	3
494	R:R:H384	R:R:S383	4.18	No	No	0	3	4
495	R:R:G391	R:R:Y387	5.79	No	No	0	5	4
496	R:R:D392	R:R:Y387	3.45	No	No	0	4	4
497	R:R:C390	R:R:I389	3.27	No	No	0	9	4
498	R:R:C398	R:R:M396	6.48	No	No	0	9	6
499	R:R:K401	R:R:T399	6.01	No	Yes	0	4	4
500	R:R:N406	R:R:S402	2.98	No	No	0	9	9
501	R:R:D403	R:R:F405	8.36	No	No	0	8	8
502	R:R:D403	R:R:N406	6.73	No	No	0	8	9
503	R:R:F405	R:R:K565	11.17	No	No	0	8	7
504	R:R:F405	R:R:V566	3.93	No	No	0	8	9
505	R:R:N406	R:R:Q489	5.28	No	No	0	9	9
506	R:R:E409	R:R:P407	7.86	Yes	No	0	9	9
507	R:R:P407	R:R:V656	7.07	No	No	0	9	7
508	R:R:E409	R:R:G413	3.27	Yes	No	0	9	9
509	R:R:E409	R:R:S657	8.62	Yes	No	0	9	8
510	R:R:E409	R:R:K660	5.4	Yes	Yes	0	9	9
511	R:R:D410	R:R:R418	8.34	No	No	0	9	9
512	R:R:I411	R:R:I470	2.94	Yes	No	0	8	8
513	R:R:I411	R:R:V473	3.07	Yes	Yes	0	8	8
514	R:R:D474	R:R:I411	9.8	No	Yes	0	9	8
515	R:R:I411	R:R:T477	3.04	Yes	No	0	8	9
516	R:R:I411	R:R:Y481	7.25	Yes	Yes	0	8	8
517	R:R:D474	R:R:M412	9.7	No	No	0	9	8
518	R:R:K660	R:R:M412	4.32	Yes	No	0	9	8
519	R:R:F416	R:R:Y414	5.16	No	No	28	6	4
520	R:R:L417	R:R:Y414	5.86	Yes	No	28	9	4
521	R:R:N658	R:R:Y414	4.65	No	No	0	8	4
522	R:R:F416	R:R:L417	7.31	No	Yes	28	6	9
523	R:R:I661	R:R:L417	4.28	No	Yes	0	9	9
524	R:R:L417	R:R:V664	4.47	Yes	Yes	0	9	9
525	R:R:D474	R:R:R418	3.57	No	No	0	9	9
526	R:R:H478	R:R:R418	3.39	No	No	0	5	9
527	R:R:V421	R:R:V664	6.41	No	Yes	0	9	9
528	R:R:A471	R:R:W422	6.48	No	Yes	0	9	9
529	R:R:L475	R:R:W422	9.11	No	Yes	0	4	9
530	R:R:P668	R:R:V424	3.53	No	No	0	9	9
531	R:R:L426	R:R:S425	4.5	No	No	0	6	8
532	R:R:C672	R:R:L427	7.94	No	No	0	9	7
533	R:R:A428	R:R:S671	3.42	No	No	0	9	9
534	R:R:F461	R:R:L429	4.87	No	Yes	0	5	7
535	R:R:D460	R:R:N432	6.73	Yes	No	0	9	9
536	R:R:N432	R:R:P675	8.15	No	No	0	9	9
537	R:R:F434	R:R:L437	3.65	Yes	No	0	7	3
538	R:R:F434	R:R:I438	7.54	Yes	No	13	7	8
539	R:R:F434	R:R:F685	4.29	Yes	Yes	13	7	9
540	R:R:L439	R:R:V435	2.98	Yes	Yes	0	8	9
541	R:R:A679	R:R:V435	3.39	No	Yes	0	9	9
542	R:R:F685	R:R:V435	5.24	Yes	Yes	0	9	9
543	R:R:A457	R:R:L436	4.73	No	No	0	9	5
544	R:R:F685	R:R:I438	12.56	Yes	No	13	9	8
545	R:R:I438	R:R:V689	3.07	No	No	13	8	5
546	R:R:L439	R:R:R450	4.86	Yes	Yes	0	8	9
547	R:R:L439	R:R:M453	5.65	Yes	No	0	8	7
548	R:R:C454	R:R:L439	6.35	No	Yes	0	8	8
549	R:R:R450	R:R:S442	3.95	Yes	No	29	9	8
550	R:R:D688	R:R:S442	7.36	No	No	29	9	8
551	R:R:H443	R:R:Y444	19.6	No	No	0	5	7
552	R:R:R687	R:R:Y444	4.12	No	No	0	7	7
553	R:R:D688	R:R:Y444	4.6	No	No	0	9	7
554	R:R:L446	R:R:R450	3.64	No	Yes	0	6	9
555	R:R:F451	R:R:L446	4.87	No	No	0	9	6
556	R:R:N447	R:R:P449	13.03	No	No	0	8	8
557	R:R:N447	R:R:R450	10.85	No	Yes	0	8	9
558	R:R:P449	R:R:V448	3.53	No	No	0	8	9
559	R:R:L452	R:R:V448	2.98	No	No	0	9	9
560	R:R:A538	R:R:V448	3.39	No	No	0	9	9
561	R:R:E518	R:R:P449	11	No	No	0	9	8
562	R:R:D688	R:R:R450	4.76	No	Yes	29	9	9
563	R:R:F451	R:R:N455	7.25	No	Yes	0	9	8
564	R:R:L452	R:R:V514	4.47	No	No	0	9	6
565	R:R:I515	R:R:L452	5.71	No	No	0	9	9
566	R:R:A679	R:R:M453	3.22	No	No	0	9	7
567	R:R:N455	R:R:T511	4.39	Yes	Yes	8	8	9
568	R:R:M542	R:R:N455	12.62	No	Yes	8	9	8
569	R:R:N455	R:R:W546	5.65	Yes	No	0	8	9
570	R:R:L456	R:R:S508	3	No	No	0	9	9
571	R:R:L456	R:R:T511	5.9	No	Yes	0	9	9
572	R:R:L456	R:R:N674	6.87	No	Yes	0	9	9
573	R:R:C462	R:R:F458	4.19	No	No	0	7	7
574	R:R:F458	R:R:W546	5.01	No	No	0	7	9
575	R:R:A459	R:R:L507	4.73	No	No	0	9	9
576	R:R:D460	R:R:S508	4.42	Yes	No	0	9	9
577	R:R:D460	R:R:S671	4.42	Yes	No	0	9	9
578	R:R:D460	R:R:N674	6.73	Yes	Yes	0	9	9
579	R:R:M463	R:R:T501	3.01	No	Yes	30	9	9
580	R:R:M463	R:R:Y667	7.18	No	Yes	30	9	9
581	R:R:M463	R:R:S671	4.6	No	No	0	9	9
582	R:R:L467	R:R:Y466	3.52	No	No	0	9	9
583	R:R:T501	R:R:Y466	9.99	Yes	No	0	9	9
584	R:R:L663	R:R:Y466	4.69	No	No	0	9	9
585	R:R:L467	R:R:P668	3.28	No	No	0	9	9
586	R:R:I470	R:R:I568	2.94	No	Yes	0	8	9
587	R:R:V473	R:R:W488	12.26	Yes	Yes	0	8	9
588	R:R:T477	R:R:Y476	4.99	No	No	0	9	5
589	R:R:H484	R:R:T477	8.21	No	No	0	6	9
590	R:R:H478	R:R:S479	8.37	No	No	0	5	7
591	R:R:E480	R:R:N483	3.94	No	No	0	6	8
592	R:R:E480	R:R:H484	8.62	No	No	0	6	6
593	R:R:A485	R:R:Y481	6.67	No	Yes	0	9	8
594	R:R:Q489	R:R:Y481	4.51	No	Yes	0	9	8
595	R:R:S567	R:R:Y481	5.09	No	Yes	0	9	8
596	R:R:N483	R:R:Y482	9.3	No	No	0	8	8
597	R:R:G493	R:R:W488	4.22	No	Yes	0	9	9
598	R:R:C494	R:R:W488	7.84	No	Yes	31	9	9
599	R:R:C569	R:R:W488	5.22	No	Yes	31	9	9
600	R:R:G491	R:R:P492	4.06	No	No	0	8	3
601	R:R:C494	R:R:C569	7.28	No	No	31	9	9
602	R:R:L557	R:R:N495	4.12	No	No	0	7	5
603	R:R:A497	R:R:C569	3.61	No	No	0	9	9
604	R:R:G498	R:R:Y563	8.69	No	Yes	0	9	9
605	R:R:F499	R:R:F550	4.29	No	No	0	8	4
606	R:R:A553	R:R:F499	5.55	No	No	0	9	8
607	R:R:F499	R:R:L557	3.65	No	No	0	8	7
608	R:R:L570	R:R:T501	2.95	No	Yes	0	9	9
609	R:R:T501	R:R:Y667	4.99	Yes	Yes	30	9	9
610	R:R:V502	R:R:Y563	6.31	No	Yes	9	9	9
611	R:R:P571	R:R:V502	3.53	Yes	No	9	9	9
612	R:R:S505	R:R:Y667	3.82	No	Yes	0	9	9
613	R:R:C549	R:R:E506	3.04	No	Yes	0	8	8
614	R:R:E506	R:R:V586	4.28	Yes	No	0	8	7
615	R:R:E506	R:R:N590	9.2	Yes	No	0	8	9
616	R:R:L507	R:R:T511	2.95	No	Yes	0	9	9
617	R:R:L507	R:R:W546	9.11	No	No	0	9	9
618	R:R:N590	R:R:V509	5.91	No	No	0	9	8
619	R:R:V514	R:R:Y510	3.79	No	Yes	8	6	7
620	R:R:I541	R:R:Y510	4.84	No	Yes	8	7	7
621	R:R:M542	R:R:Y510	3.59	No	Yes	8	9	7
622	R:R:G545	R:R:Y510	8.69	No	Yes	0	9	7
623	R:R:M542	R:R:T511	6.02	No	Yes	8	9	9
624	R:R:L512	R:R:V597	4.47	No	No	0	9	9
625	R:R:T513	R:R:V597	3.17	No	No	0	9	9
626	R:R:I541	R:R:V514	3.07	No	No	8	7	6
627	R:R:T516	R:R:V597	9.52	No	No	0	9	9
628	R:R:T516	R:R:Y601	11.24	No	Yes	0	9	9
629	R:R:C600	R:R:L517	3.17	No	No	0	9	5
630	R:R:R519	R:R:Y601	6.17	No	Yes	0	9	9
631	R:R:R519	R:R:Y678	4.12	No	No	0	9	9
632	R:R:T524	R:R:W520	7.28	No	Yes	0	8	7
633	R:R:C600	R:R:W520	3.92	No	Yes	0	9	7
634	R:R:K603	R:R:W520	4.64	No	Yes	0	7	7
635	R:R:I604	R:R:W520	3.52	No	Yes	0	9	7
636	R:R:F525	R:R:Y521	10.32	No	No	0	6	6
637	R:R:R531	R:R:Y521	3.09	No	No	0	7	6
638	R:R:I533	R:R:Y521	8.46	No	No	0	5	6
639	R:R:I523	R:R:I604	4.42	No	No	0	9	9
640	R:R:F525	R:R:T524	7.78	No	No	0	6	8
641	R:R:D530	R:R:R528	11.91	No	No	0	8	7
642	R:R:R528	R:R:R531	20.26	No	No	0	7	7
643	R:R:R534	R:R:R536	8.53	No	No	0	7	5
644	R:R:H537	R:R:R534	9.03	No	No	0	7	7
645	R:R:F585	R:R:L552	4.87	No	No	0	4	7
646	R:R:L555	R:R:P556	3.28	No	No	9	7	9
647	R:R:L555	R:R:Y582	7.03	No	Yes	9	7	9
648	R:R:P556	R:R:Y563	15.3	No	Yes	9	9	9
649	R:R:P556	R:R:Y582	12.52	No	Yes	9	9	9
650	R:R:L557	R:R:Y563	3.52	No	Yes	0	7	9
651	R:R:I560	R:R:L578	5.71	No	No	0	7	3
652	R:R:D573	R:R:S561	5.89	Yes	No	32	8	9
653	R:R:A579	R:R:S561	3.42	No	No	32	8	9
654	R:R:D573	R:R:S562	7.36	Yes	No	0	8	8
655	R:R:P571	R:R:Y563	8.34	Yes	Yes	9	9	9
656	R:R:I568	R:R:V566	4.61	Yes	No	0	9	9
657	R:R:K660	R:R:S567	3.06	Yes	No	0	9	9
658	R:R:I568	R:R:L570	8.56	Yes	No	0	9	9
659	R:R:I568	R:R:K660	2.91	Yes	Yes	0	9	9
660	R:R:I568	R:R:L663	5.71	Yes	No	0	9	9
661	R:R:L570	R:R:P571	3.28	No	Yes	0	9	9
662	R:R:I583	R:R:P571	3.39	Yes	Yes	0	7	9
663	R:R:D573	R:R:E575	9.09	Yes	No	0	8	4
664	R:R:A579	R:R:D573	4.63	No	Yes	32	8	8
665	R:R:P577	R:R:T576	3.5	No	No	0	3	6
666	R:R:I583	R:R:Y582	3.63	Yes	Yes	0	7	9
667	R:R:V586	R:R:Y582	3.79	No	Yes	0	7	9
668	R:R:A644	R:R:L587	3.15	No	No	0	9	8
669	R:R:L587	R:R:L645	4.15	No	No	0	8	7
670	R:R:I596	R:R:V592	3.07	No	No	0	6	3
671	R:R:C598	R:R:F594	4.19	No	Yes	0	7	8
672	R:R:D633	R:R:F594	4.78	No	Yes	0	8	8
673	R:R:F594	R:R:F634	6.43	Yes	No	0	8	9
674	R:R:I630	R:R:Y601	4.84	No	Yes	0	9	9
675	R:R:K603	R:R:T607	3	No	No	0	7	7
676	R:R:R609	R:R:Y605	10.29	No	No	0	7	9
677	R:R:M626	R:R:Y605	3.59	No	No	0	9	9
678	R:R:D619	R:R:R609	10.72	No	No	0	9	7
679	R:R:K624	R:R:T620	3	No	No	0	9	7
680	R:R:L677	R:R:V628	2.98	No	No	0	9	6
681	R:R:L629	R:R:L677	5.54	No	No	0	9	9
682	R:R:L629	R:R:Y678	11.72	No	No	0	9	9
683	R:R:F631	R:R:I635	12.56	No	No	0	8	6
684	R:R:L677	R:R:T632	4.42	No	No	0	9	9
685	R:R:D633	R:R:N670	5.39	No	No	0	8	9
686	R:R:A638	R:R:F634	8.32	No	No	0	8	9
687	R:R:C636	R:R:L669	4.76	No	No	0	9	8
688	R:R:C636	R:R:N670	12.6	No	No	0	9	9
689	R:R:M637	R:R:S641	6.13	No	No	0	7	9
690	R:R:I640	R:R:Y667	4.84	No	Yes	0	9	9
691	R:R:F642	R:R:Y643	16.5	No	Yes	0	9	8
692	R:R:L653	R:R:Y643	5.86	No	Yes	0	9	8
693	R:R:I654	R:R:Y643	6.04	No	Yes	0	9	8
694	R:R:L662	R:R:Y643	3.52	No	Yes	0	8	8
695	R:R:I654	R:R:N658	5.66	No	No	0	9	8
696	R:R:I654	R:R:S659	4.64	No	No	0	9	9
697	R:R:N658	R:R:T655	5.85	No	No	0	8	8
698	R:R:F666	R:R:L662	3.65	No	No	0	8	8
699	R:R:L665	R:R:V664	2.98	No	Yes	0	8	9
700	R:R:F666	R:R:L665	4.87	No	No	0	8	8
701	R:R:N670	R:R:N674	8.17	No	Yes	0	9	9
702	R:R:N674	R:R:Y678	5.81	Yes	No	0	9	9
703	R:R:F676	R:R:I680	3.77	No	No	0	8	9
704	R:R:K683	R:R:Q686	10.85	No	No	0	8	7
705	R:R:F685	R:R:V689	3.93	Yes	No	13	9	5
706	R:R:L693	R:R:V689	2.98	No	No	0	7	5
707	R:R:F696	R:R:L692	6.09	No	No	0	4	8
708	R:R:D203	R:R:T181	2.89	No	No	0	6	7
709	R:R:D276	R:R:T399	2.89	Yes	Yes	0	4	4
710	R:R:P48	R:R:R46	2.88	Yes	No	0	9	1
711	R:R:K139	R:R:M140	2.88	No	No	0	4	1
712	R:R:K565	R:R:M572	2.88	No	No	0	7	9
713	L:L:Q20	L:L:V70	2.87	No	No	0	0	0
714	R:R:E394	R:R:S393	2.87	No	No	0	5	3
715	M:M:I58	M:M:L81	2.85	No	No	0	0	0
716	R:R:I158	R:R:L184	2.85	Yes	No	0	7	8
717	R:R:I292	R:R:L270	2.85	No	No	0	5	3
718	R:R:I295	R:R:L299	2.85	No	No	0	3	3
719	R:R:I596	R:R:L517	2.85	No	No	0	6	5
720	R:R:I560	R:R:L555	2.85	No	No	0	7	7
721	R:R:I583	R:R:L587	2.85	Yes	No	0	7	8
722	R:R:I698	R:R:L693	2.85	No	No	0	3	7
723	R:R:K102	R:R:N77	2.8	No	No	0	4	8
724	L:L:C60	M:M:R34	2.79	No	No	0	0	0
725	R:R:H70	R:R:S69	2.79	Yes	No	0	4	4
726	R:R:H95	R:R:S94	2.79	No	No	0	5	4
727	R:R:C549	R:R:F503	2.79	No	No	0	8	9
728	R:R:D43	R:R:K42	2.77	No	No	0	4	2
729	R:R:D217	R:R:K218	2.77	No	No	0	5	4
730	R:R:L231	R:R:L252	2.77	Yes	No	0	7	9
731	R:R:L241	R:R:L252	2.77	Yes	No	0	9	9
732	R:R:D395	R:R:M396	2.77	No	No	0	3	6
733	R:R:H63	R:R:T88	2.74	No	No	0	4	4
734	R:R:E178	R:R:K201	2.7	No	No	0	5	4
735	R:R:E575	R:R:K565	2.7	No	No	0	4	7
736	L:L:A36	M:M:Y54	2.67	No	Yes	0	0	0
737	R:R:E506	R:R:L589	2.65	Yes	No	0	8	3
738	R:R:R112	R:R:V87	2.62	No	No	0	6	4
739	R:R:F221	R:R:V224	2.62	Yes	No	0	9	7
740	R:R:R80	R:R:T104	2.59	Yes	No	0	4	5
741	R:R:F500	R:R:T496	2.59	No	No	0	7	5
742	R:R:Q90	R:R:Q91	2.56	No	Yes	0	4	3
743	R:R:F666	R:R:I635	2.51	No	No	0	8	6
744	R:R:F681	R:R:I680	2.51	No	No	0	8	9
745	R:R:F685	R:R:I680	2.51	Yes	No	0	9	9
746	R:R:F696	R:R:I698	2.51	No	No	0	4	3
747	M:M:T53	M:M:Y54	2.5	No	Yes	0	0	0
748	R:R:F594	R:R:M637	2.49	Yes	No	0	8	7
749	L:L:F74	L:L:K75	2.48	Yes	No	0	0	0
750	R:R:S278	R:R:W258	2.47	No	No	0	9	4
751	R:R:S425	R:R:W422	2.47	No	Yes	0	8	9
752	R:R:V421	R:R:W422	2.45	No	Yes	0	9	9
753	R:R:F676	R:R:L427	2.44	No	No	0	8	7
754	R:R:F550	R:R:L554	2.44	No	No	0	4	5
755	M:M:K101	M:M:Y104	2.39	No	No	0	0	0
756	R:R:M626	R:R:Y601	2.39	No	Yes	0	9	9
757	R:R:D36	R:R:R38	2.38	No	Yes	0	3	4
758	R:R:F37	R:R:Q33	2.34	No	No	0	1	5
759	R:R:F690	R:R:Q686	2.34	No	No	0	5	7
760	R:R:E124	R:R:Y148	2.24	No	No	0	4	4
761	L:L:G72	L:L:G73	2.11	No	No	0	0	0
762	R:R:G544	R:R:G545	2.11	No	No	0	3	9
763	L:L:G30	L:L:P8	2.03	No	Yes	0	0	0
764	L:L:G22	L:L:P24	2.03	No	No	0	0	0
765	R:R:P51	R:R:P52	1.95	Yes	No	0	5	3
766	R:R:A428	R:R:G464	1.95	No	No	0	9	9
767	L:L:C7	L:L:P8	1.88	No	Yes	14	0	0
768	L:L:C31	L:L:P8	1.88	No	Yes	14	0	0
769	L:L:A23	L:L:P24	1.87	No	No	0	0	0
770	M:M:A72	M:M:P73	1.87	No	Yes	0	0	0
771	R:R:A220	R:R:P242	1.87	No	Yes	0	8	9
772	R:R:A638	R:R:P639	1.87	No	No	0	8	9
773	R:R:A647	R:R:P652	1.87	No	No	0	9	9
774	L:L:G72	L:L:V70	1.84	No	No	0	0	0
775	R:R:G544	R:R:V547	1.84	No	No	0	3	3
776	M:M:C2	M:M:C27	1.82	Yes	Yes	7	0	0
777	M:M:C2	M:M:C31	1.82	Yes	No	7	0	0
778	M:M:C2	M:M:C83	1.82	Yes	No	7	0	0
779	M:M:C2	M:M:C85	1.82	Yes	No	7	0	0
780	M:M:C27	M:M:C52	1.82	Yes	No	7	0	0
781	M:M:C31	M:M:C52	1.82	No	No	7	0	0
782	R:R:G174	R:R:T145	1.82	No	No	0	9	4
783	R:R:A275	R:R:C398	1.81	No	No	0	9	9
784	R:R:A504	R:R:C462	1.81	No	No	0	8	7
785	R:R:P126	R:R:S101	1.78	No	No	0	5	4
786	R:R:P400	R:R:T399	1.75	No	Yes	0	9	4
787	R:R:P492	R:R:T496	1.75	No	No	0	3	5
788	L:L:C59	L:L:V61	1.71	Yes	No	0	0	0
789	L:L:A81	L:L:S64	1.71	No	No	0	0	0
790	M:M:G38	M:M:L42	1.71	No	No	0	0	0
791	R:R:G245	R:R:L246	1.71	No	Yes	0	9	7
792	R:R:A485	R:R:S281	1.71	No	No	0	9	9
793	R:R:G431	R:R:L430	1.71	No	No	0	9	5
794	R:R:C599	R:R:V595	1.71	No	No	0	4	3
795	R:R:G188	R:R:N187	1.7	No	Yes	0	6	9
796	R:R:A196	R:R:V192	1.7	No	No	0	9	7
797	R:R:A457	R:R:V435	1.7	No	Yes	0	9	9
798	R:R:A593	R:R:V509	1.7	No	No	0	9	8
799	M:M:C95	M:M:T90	1.69	No	No	0	0	0
800	R:R:C600	R:R:T516	1.69	No	No	0	9	9
801	M:M:A46	R:R:T388	1.68	No	No	0	0	4
802	R:R:A579	R:R:T576	1.68	No	No	0	8	6
803	R:R:A673	R:R:T632	1.68	No	No	0	9	9
804	R:R:A684	R:R:T682	1.68	No	No	0	8	9
805	R:R:K651	R:R:P652	1.67	No	No	0	4	9
806	R:R:L75	R:R:P76	1.64	No	No	0	6	5
807	R:R:L125	R:R:P126	1.64	Yes	No	0	8	5
808	R:R:G194	R:R:Q193	1.64	No	No	0	3	5
809	R:R:L662	R:R:P639	1.64	No	No	0	8	9
810	R:R:S304	R:R:S305	1.63	No	No	0	5	2
811	M:M:A46	R:R:I389	1.62	No	No	0	0	4
812	R:R:A121	R:R:I117	1.62	No	No	0	9	8
813	R:R:S149	R:R:V147	1.62	No	No	0	8	7
814	R:R:S191	R:R:V215	1.62	No	No	0	4	2
815	R:R:S472	R:R:V473	1.62	No	Yes	0	8	8
816	L:L:S92	M:M:T90	1.6	No	No	0	0	0
817	R:R:S166	R:R:T165	1.6	No	No	0	5	4
818	R:R:S237	R:R:T214	1.6	No	No	0	4	4
819	R:R:S237	R:R:T259	1.6	No	No	0	4	5
820	R:R:V420	R:R:V424	1.6	No	No	0	6	9
821	R:R:V420	R:R:V664	1.6	No	Yes	0	6	9
822	M:M:T25	M:M:V79	1.59	No	Yes	0	0	0
823	R:R:G227	R:R:H248	1.59	No	No	0	7	4
824	R:R:T399	R:R:V397	1.59	Yes	No	0	4	2
825	R:R:C548	R:R:L552	1.59	No	No	0	4	7
826	R:R:T588	R:R:V592	1.59	No	No	0	3	3
827	R:R:T607	R:R:V608	1.59	No	No	0	7	9
828	L:L:E9	L:L:P8	1.57	No	Yes	0	0	0
829	M:M:T21	M:M:T8	1.57	No	No	0	0	0
830	R:R:I691	R:R:S694	1.55	No	No	0	6	8
831	R:R:I560	R:R:V558	1.54	No	No	0	7	4
832	R:R:I648	R:R:V584	1.54	No	No	0	6	5
833	R:R:I591	R:R:V592	1.54	No	No	0	6	3
834	R:R:C24	R:R:Q33	1.53	No	No	21	9	5
835	R:R:C31	R:R:Q33	1.53	No	No	21	8	5
836	R:R:K250	R:R:S229	1.53	No	No	0	7	5
837	R:R:I486	R:R:T490	1.52	No	No	0	8	8
838	R:R:I583	R:R:T574	1.52	Yes	No	0	7	6
839	M:M:F41	R:R:G294	1.51	No	No	0	0	5
840	R:R:F434	R:R:G431	1.51	Yes	No	0	7	9
841	R:R:A522	R:R:E518	1.51	No	No	0	8	9
842	R:R:K139	R:R:T115	1.5	No	No	0	4	4
843	R:R:L270	R:R:S268	1.5	No	No	0	3	5
844	R:R:L653	R:R:S646	1.5	No	No	0	9	9
845	R:R:N302	R:R:S298	1.49	No	No	0	7	4
846	R:R:L429	R:R:V433	1.49	Yes	No	0	7	3
847	R:R:L469	R:R:V473	1.49	No	Yes	0	7	8
848	R:R:L551	R:R:V547	1.49	No	No	0	2	3
849	R:R:L552	R:R:V586	1.49	No	No	0	7	7
850	R:R:L580	R:R:V584	1.49	No	No	0	4	5
851	R:R:L580	R:R:T574	1.47	No	No	0	4	6
852	R:R:I583	R:R:I648	1.47	Yes	No	0	7	6
853	R:R:I622	R:R:M626	1.46	No	No	0	8	9
854	M:M:G29	M:M:Y30	1.45	No	No	0	0	0
855	R:R:I292	R:R:K290	1.45	No	No	0	5	5
856	R:R:D619	R:R:T620	1.45	No	No	0	9	7
857	R:R:K209	R:R:K211	1.44	Yes	No	0	7	3
858	R:R:K532	R:R:L529	1.41	No	No	0	8	8
859	R:R:K262	R:R:N483	1.4	No	No	0	5	8
860	L:L:M29	R:R:D382	1.39	No	No	0	0	4
861	R:R:L429	R:R:L430	1.38	Yes	No	0	7	5
862	R:R:L429	R:R:L468	1.38	Yes	No	0	7	7
863	R:R:A684	R:R:R450	1.38	No	Yes	0	8	9
864	R:R:A684	R:R:R687	1.38	No	No	0	8	7
865	M:M:A17	M:M:Y18	1.33	No	No	0	0	0
866	R:R:E480	R:R:L265	1.33	No	No	0	6	7
867	R:R:H443	R:R:I691	1.33	No	No	0	5	6
868	R:R:H537	R:R:I533	1.33	No	No	0	7	5
869	R:R:A623	R:R:Y605	1.33	No	No	0	9	9
870	R:R:D403	R:R:E404	1.3	No	No	0	8	7
871	M:M:F1	M:M:I3	1.26	No	No	0	0	0
872	R:R:T115	R:R:Y116	1.25	No	No	0	4	3
873	R:R:T190	R:R:Y212	1.25	No	No	0	5	3
874	R:R:K621	R:R:R625	1.24	No	No	0	6	9
875	R:R:K683	R:R:R687	1.24	No	No	0	8	7
876	R:R:E30	R:R:H32	1.23	No	Yes	0	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:P8	1.84	4	14	0
2	L:L:N15	5.945	4	3	0
3	L:L:F17	5.21	5	3	0
4	L:L:F18	7.815	4	3	0
5	L:L:Q27	8.11	4	3	0
6	L:L:T39	4.3975	4	10	0
7	L:L:C59	5.885	4	19	0
8	L:L:F74	5.0225	4	0	0
9	L:L:V76	8.255	4	0	0
10	L:L:H79	9.5725	4	3	0
11	L:L:T86	8.6125	4	2	0
12	L:L:Y88	6.236	5	2	0
13	L:L:Y89	6.1675	4	0	0
14	L:L:H90	7.1025	4	0	0
15	L:L:K91	6.4375	4	0	0
16	M:M:C2	2.912	5	7	0
17	M:M:Y7	8.6675	4	6	0
18	M:M:M9	4.73	5	6	0
19	M:M:E12	8.36	5	17	0
20	M:M:R13	4.914	5	4	0
21	M:M:E15	8.14	5	4	0
22	M:M:T24	4.0425	4	6	0
23	M:M:I26	6.1425	4	0	0
24	M:M:C27	3.7375	4	7	0
25	M:M:K39	4.2	4	0	0
26	M:M:K44	6.545	4	0	0
27	M:M:Q49	6.97	4	19	0
28	M:M:Y54	5.92667	6	0	0
29	M:M:F57	6.86	4	0	0
30	M:M:R60	7.585	4	6	0
31	M:M:I64	4.0225	4	0	0
32	M:M:P73	4.81	4	20	0
33	M:M:Y77	7.485	6	6	0
34	M:M:V79	3.1175	4	6	0
35	M:M:Y92	8.67	4	18	0
36	M:M:T102	4.2825	4	10	0
37	R:R:H32	4.405	4	2	5
38	R:R:R38	5.06	4	2	4
39	R:R:T40	5.1	4	2	8
40	R:R:I44	4.285	4	12	5
41	R:R:P48	3.33	4	22	9
42	R:R:L50	3.59	4	22	5
43	R:R:P51	4.815	4	0	5
44	R:R:K58	7.7175	4	2	5
45	R:R:L59	3.685	4	0	6
46	R:R:I60	5.2575	4	2	4
47	R:R:T62	5.8875	4	12	7
48	R:R:L64	5.34	4	12	6
49	R:R:H70	5.2725	4	24	4
50	R:R:F72	5.3675	4	0	9
51	R:R:R80	7.42667	6	2	4
52	R:R:Y82	9.32	5	2	4
53	R:R:D86	5.9525	4	12	8
54	R:R:Q91	4.2125	4	23	3
55	R:R:Y98	6.725	4	24	2
56	R:R:H105	9.755	6	2	7
57	R:R:E107	7.3825	4	2	6
58	R:R:R109	8.432	5	0	5
59	R:R:D118	6.61	4	0	5
60	R:R:L125	3.6025	4	0	8
61	R:R:F130	6.938	5	2	6
62	R:R:F134	11.0675	4	0	5
63	R:R:N135	5.2175	4	11	8
64	R:R:T136	4.08667	6	1	9
65	R:R:F141	6.84	4	0	7
66	R:R:P142	6.2275	4	0	9
67	R:R:F154	6.034	5	1	6
68	R:R:L156	4.932	5	1	7
69	R:R:E157	8.04	4	0	8
70	R:R:I158	4.394	5	1	7
71	R:R:D160	5.882	5	11	8
72	R:R:N161	7.3825	4	1	8
73	R:R:F172	5.65833	6	1	8
74	R:R:L175	6.38	4	1	7
75	R:R:N187	7.38	4	1	9
76	R:R:F189	9.422	5	1	8
77	R:R:N198	4.664	5	26	7
78	R:R:Y206	4.975	4	5	6
79	R:R:N208	7.025	4	5	5
80	R:R:K209	5.552	5	0	7
81	R:R:F221	5.172	5	0	9
82	R:R:L231	3.095	4	0	7
83	R:R:D232	9.495	4	5	9
84	R:R:V238	4.2875	4	1	7
85	R:R:L241	3.37	4	0	9
86	R:R:P242	4.6225	4	0	9
87	R:R:L246	5.3625	4	0	7
88	R:R:I253	7.9175	4	5	4
89	R:R:D276	7.112	5	5	4
90	R:R:F286	5.306	5	0	8
91	R:R:L296	5.42	4	3	4
92	R:R:T399	3.06	4	0	4
93	R:R:E409	6.2875	4	0	9
94	R:R:I411	5.22	5	0	8
95	R:R:L417	5.48	4	28	9
96	R:R:W422	5.1275	4	0	9
97	R:R:L429	2.28	4	0	7
98	R:R:F434	4.2475	4	13	7
99	R:R:V435	3.3275	4	0	9
100	R:R:L439	4.96	4	0	8
101	R:R:R450	4.90667	6	29	9
102	R:R:N455	7.4775	4	8	8
103	R:R:D460	5.575	4	0	9
104	R:R:V473	4.61	4	0	8
105	R:R:Y481	5.88	4	0	8
106	R:R:W488	7.385	4	31	9
107	R:R:T501	5.235	4	30	9
108	R:R:E506	4.7925	4	0	8
109	R:R:Y510	5.2275	4	8	7
110	R:R:T511	4.815	4	8	9
111	R:R:W520	4.84	4	0	7
112	R:R:Y563	8.432	5	9	9
113	R:R:I568	4.946	5	0	9
114	R:R:P571	4.635	4	9	9
115	R:R:D573	6.7425	4	32	8
116	R:R:Y582	6.7425	4	9	9
117	R:R:I583	2.572	5	0	7
118	R:R:F594	4.4725	4	0	8
119	R:R:Y601	6.16	4	0	9
120	R:R:Y643	7.98	4	0	8
121	R:R:K660	3.9225	4	0	9
122	R:R:V664	3.865	4	0	9
123	R:R:Y667	5.2075	4	30	9
124	R:R:N674	6.895	4	0	9
125	R:R:F685	5.706	5	13	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E107	R:R:H105	13.6945	9.85	Yes	Yes	2	6	7
2	R:R:E107	R:R:R109	34.4149	4.65	Yes	Yes	0	6	5
3	M:M:I96	R:R:R109	20.8066	6.26	No	Yes	0	0	5
4	L:L:T54	M:M:I96	20.598	3.04	No	No	0	0	0
5	L:L:T54	L:L:Y37	20.7795	8.74	No	No	0	0	0
6	L:L:K91	R:R:R109	14.8733	3.71	Yes	Yes	0	0	5
7	L:L:H90	L:L:K91	13.2637	11.79	Yes	Yes	0	0	0
8	L:L:H90	M:M:Q49	11.1106	3.71	Yes	Yes	0	0	0
9	L:L:Y89	M:M:Q49	10.0106	12.4	Yes	Yes	0	0	0
10	L:L:Y89	M:M:K39	20.0022	4.78	Yes	Yes	0	0	0
11	M:M:D35	M:M:K39	12.0648	4.15	No	Yes	0	0	0
12	L:L:Y88	R:R:H105	10.6854	7.62	Yes	Yes	2	0	7
13	L:L:Y88	L:L:Y89	11.2026	3.97	Yes	Yes	0	0	0
14	R:R:L230	R:R:Y206	19.1694	4.69	No	Yes	0	4	6
15	L:L:Y37	M:M:I26	18.0244	4.84	No	Yes	0	0	0
16	M:M:I26	M:M:Y7	10.9173	13.3	Yes	Yes	0	0	0
17	M:M:I11	M:M:M9	10.0345	2.92	No	Yes	0	0	0
18	R:R:N110	R:R:R109	62.8164	7.23	No	Yes	0	6	5
19	R:R:N110	R:R:N135	62.9251	5.45	No	Yes	0	6	8
20	L:L:L48	R:R:N135	99.1258	4.12	No	Yes	0	0	8
21	L:L:L48	R:R:P162	99.2193	3.28	No	No	0	0	7
22	R:R:E107	R:R:Y82	10.8502	11.22	Yes	Yes	2	6	4
23	R:R:T159	R:R:Y185	15.117	11.24	No	No	0	5	7
24	R:R:D160	R:R:N186	18.3693	5.39	Yes	No	0	8	7
25	R:R:K209	R:R:N186	18.1846	5.6	Yes	No	0	7	7
26	M:M:D91	R:R:K209	11.5734	6.91	No	Yes	0	0	7
27	M:M:N89	M:M:Y92	11.1711	16.28	No	Yes	0	0	0
28	R:R:K58	R:R:Y82	10.8373	9.55	Yes	Yes	2	5	4
29	R:R:P162	R:R:Y163	99.3126	6.95	No	No	0	7	4
30	R:R:G137	R:R:Y163	99.4057	2.9	No	No	0	8	4
31	R:R:G137	R:R:T136	99.4986	3.64	No	Yes	0	8	9
32	R:R:K58	R:R:T40	16.264	7.51	Yes	Yes	2	5	8
33	R:R:K42	R:R:T40	16.0692	3	No	Yes	0	2	8
34	R:R:D43	R:R:K42	15.6496	2.77	No	No	0	4	2
35	R:R:D43	R:R:H63	15.2298	7.56	No	No	0	4	4
36	R:R:H63	R:R:T88	14.3897	2.74	No	No	0	4	4
37	R:R:R65	R:R:T88	13.9694	5.17	No	No	0	4	4
38	R:R:Q90	R:R:R65	13.549	14.02	No	No	0	4	4
39	R:R:Q90	R:R:Q91	12.7075	2.56	No	Yes	0	4	3
40	R:R:I133	R:R:T136	48.3818	3.04	No	Yes	0	8	9
41	R:R:I133	R:R:P142	48.3922	3.39	No	Yes	0	8	9
42	R:R:N161	R:R:T136	49.8442	5.85	Yes	Yes	1	8	9
43	R:R:I158	R:R:N161	47.6273	4.25	Yes	Yes	1	7	8
44	R:R:I158	R:R:L156	47.727	8.56	Yes	Yes	1	7	7
45	R:R:F141	R:R:P142	47.5064	11.56	Yes	Yes	0	7	9
46	R:R:F141	R:R:F172	48.1943	4.29	Yes	Yes	0	7	8
47	R:R:F172	R:R:L156	47.6832	3.65	Yes	Yes	1	8	7
48	R:R:F172	R:R:F197	100	4.29	Yes	No	0	8	9
49	R:R:F197	R:R:F221	99.8297	7.5	No	Yes	0	9	9
50	R:R:F221	R:R:P228	49.6903	7.22	Yes	No	0	9	8
51	R:R:L249	R:R:P228	49.4003	3.28	No	No	0	8	8
52	R:R:F269	R:R:L249	99.3096	3.65	No	No	0	7	8
53	R:R:F221	R:R:L246	49.7809	4.87	Yes	Yes	0	9	7
54	R:R:L246	R:R:L249	50.1456	8.3	Yes	No	0	7	8
55	R:R:F269	R:R:F286	95.1972	6.43	No	Yes	0	7	8
56	R:R:A285	R:R:F286	93.3511	5.55	No	Yes	0	8	8
57	R:R:A285	R:R:Y482	93.1195	5.34	No	No	0	8	8
58	R:R:N483	R:R:Y482	92.4237	9.3	No	No	0	8	8
59	R:R:E480	R:R:N483	91.959	3.94	No	No	0	6	8
60	R:R:E480	R:R:H484	91.4935	8.62	No	No	0	6	6
61	R:R:H484	R:R:T477	91.2605	8.21	No	No	0	6	9
62	R:R:I411	R:R:T477	90.794	3.04	Yes	No	0	8	9
63	R:R:I411	R:R:I470	81.2961	2.94	Yes	No	0	8	8
64	R:R:I470	R:R:I568	81.0574	2.94	No	Yes	0	8	9
65	R:R:I568	R:R:L570	68.8421	8.56	Yes	No	0	9	9
66	R:R:L570	R:R:T501	58.9584	2.95	No	Yes	0	9	9
67	R:R:M463	R:R:T501	58.0761	3.01	No	Yes	30	9	9
68	R:R:M463	R:R:S671	57.8761	4.6	No	No	0	9	9
69	R:R:D460	R:R:S671	57.1109	4.42	Yes	No	0	9	9
70	R:R:D460	R:R:S508	20.8944	4.42	Yes	No	0	9	9
71	R:R:L456	R:R:S508	20.6265	3	No	No	0	9	9
72	R:R:L456	R:R:T511	41.2161	5.9	No	Yes	0	9	9
73	R:R:N455	R:R:T511	28.9758	4.39	Yes	Yes	8	8	9
74	R:R:F451	R:R:N455	26.2466	7.25	No	Yes	0	9	8
75	R:R:F451	R:R:L446	25.6921	4.87	No	No	0	9	6
76	R:R:L446	R:R:R450	25.1378	3.64	No	Yes	0	6	9
77	R:R:L439	R:R:R450	15.6995	4.86	Yes	Yes	0	8	9
78	R:R:L439	R:R:V435	13.463	2.98	Yes	Yes	0	8	9
79	R:R:F685	R:R:V435	11.2281	5.24	Yes	Yes	0	9	9
80	R:R:D460	R:R:N674	35.462	6.73	Yes	Yes	0	9	9
81	R:R:L456	R:R:N674	21.1518	6.87	No	Yes	0	9	9
82	R:R:L570	R:R:P571	11.3486	3.28	No	Yes	0	9	9
83	R:R:N674	R:R:Y678	12.2528	5.81	Yes	No	0	9	9
84	R:R:R519	R:R:Y678	10.5627	4.12	No	No	0	9	9
85	R:R:R519	R:R:Y601	10.2809	6.17	No	Yes	0	9	9
86	R:R:D160	R:R:T159	16.3259	11.56	Yes	No	0	8	5
87	R:R:D160	R:R:N135	35.3011	5.39	Yes	Yes	11	8	8
88	R:R:K209	R:R:N208	10.6838	8.39	Yes	Yes	0	7	5
89	M:M:D91	M:M:N89	11.3693	10.77	No	No	0	0	0
90	R:R:N208	R:R:Y206	13.4203	3.49	Yes	Yes	5	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:F17	R:R:M300	7.46	3	Yes	No	0	3	0	1
L:L:F17	R:R:D386	5.97	3	Yes	No	0	5	0	1
L:L:F18	R:R:L296	6.09	3	Yes	Yes	0	4	0	1
L:L:F18	R:R:M300	6.22	3	Yes	No	0	3	0	1
L:L:T46	R:R:I85	3.04	0	No	No	0	6	0	1
L:L:T46	R:R:V87	3.17	0	No	No	0	4	0	1
L:L:L48	R:R:N135	4.12	0	No	Yes	0	8	0	1
L:L:L48	R:R:P162	3.28	0	No	No	0	7	0	1
L:L:V49	R:R:N135	5.91	11	No	Yes	0	8	0	1
L:L:V49	R:R:D160	2.92	11	No	Yes	0	8	0	1
L:L:K51	R:R:D160	4.15	11	No	Yes	0	8	0	1
L:L:R67	R:R:I152	12.53	0	No	No	0	3	0	1
L:L:R67	R:R:F153	3.21	0	No	No	0	5	0	1
L:L:F74	R:R:L296	3.65	0	Yes	Yes	0	4	0	1
L:L:T86	R:R:R80	5.17	2	Yes	Yes	0	4	0	1
L:L:T86	R:R:H105	4.11	2	Yes	Yes	0	7	0	1
L:L:Y88	R:R:H105	7.62	2	Yes	Yes	0	7	0	1
L:L:Y88	R:R:F130	7.22	2	Yes	Yes	0	6	0	1
L:L:Y88	R:R:I155	3.63	2	Yes	No	0	5	0	1
L:L:K91	R:R:R109	3.71	0	Yes	Yes	0	5	0	1
L:L:K91	R:R:E157	5.4	0	Yes	Yes	0	8	0	1
M:M:M32	R:R:F381	7.46	0	No	No	0	4	0	1
M:M:R34	R:R:Y385	5.14	0	No	No	0	4	0	1
M:M:K39	R:R:F153	4.96	0	Yes	No	0	5	0	1
M:M:F41	R:R:L296	4.87	0	No	Yes	0	4	0	1
M:M:F41	R:R:E297	7	0	No	No	0	5	0	1
M:M:L42	R:R:E297	3.98	0	No	No	0	5	0	1
M:M:P43	R:R:E251	4.72	0	No	No	0	5	0	1
M:M:K44	R:R:D203	11.06	0	Yes	No	0	6	0	1
M:M:K44	R:R:A204	6.42	0	Yes	No	0	5	0	1
M:M:K44	R:R:S229	3.06	0	Yes	No	0	5	0	1
M:M:K44	R:R:L230	5.64	0	Yes	No	0	4	0	1
M:M:Y45	R:R:I253	6.04	5	No	Yes	0	4	0	1
M:M:Y45	R:R:R274	3.09	5	No	No	0	3	0	1
M:M:Y45	R:R:D276	3.45	5	No	Yes	0	4	0	1
M:M:D91	R:R:K209	6.91	0	No	Yes	0	7	0	1
M:M:I96	R:R:R109	6.26	0	No	Yes	0	5	0	1
M:M:E98	R:R:K58	9.45	2	No	Yes	0	5	0	1
M:M:E98	R:R:Y82	7.86	2	No	Yes	0	4	0	1
M:M:E98	R:R:E107	3.81	2	No	Yes	0	6	0	1
M:M:I100	R:R:I60	5.89	0	No	Yes	0	4	0	1
M:M:T102	R:R:E61	5.64	10	Yes	No	0	5	0	1
R:R:K58	R:R:T40	7.51	2	Yes	Yes	5	8	1	2
R:R:I60	R:R:T40	3.04	2	Yes	Yes	4	8	1	2
R:R:R80	R:R:T56	6.47	2	Yes	No	4	5	1	2
R:R:I60	R:R:K58	4.36	2	Yes	Yes	4	5	1	1
R:R:K58	R:R:Y82	9.55	2	Yes	Yes	5	4	1	1
R:R:I60	R:R:S84	7.74	2	Yes	No	4	7	1	2
R:R:E61	R:R:I85	5.47	0	No	No	5	6	1	1
R:R:R80	R:R:S79	5.27	2	Yes	No	4	7	1	2
R:R:R80	R:R:Y82	9.26	2	Yes	Yes	4	4	1	1
R:R:H105	R:R:R80	15.8	2	Yes	Yes	7	4	1	1
R:R:H105	R:R:Y82	8.71	2	Yes	Yes	7	4	1	1
R:R:E107	R:R:Y82	11.22	2	Yes	Yes	6	4	1	1
R:R:I85	R:R:S84	6.19	0	No	No	6	7	1	2
R:R:E107	R:R:H105	9.85	2	Yes	Yes	6	7	1	1
R:R:F130	R:R:H105	12.44	2	Yes	Yes	6	7	1	1
R:R:E107	R:R:R109	4.65	2	Yes	Yes	6	5	1	1
R:R:N110	R:R:R109	7.23	0	No	Yes	6	5	2	1
R:R:F134	R:R:R109	20.31	0	Yes	Yes	5	5	2	1
R:R:N110	R:R:N135	5.45	0	No	Yes	6	8	2	1
R:R:F130	R:R:G132	3.01	2	Yes	No	6	5	1	2
R:R:F130	R:R:I155	5.02	2	Yes	No	6	5	1	1
R:R:E157	R:R:F130	7	0	Yes	Yes	8	6	1	1
R:R:F134	R:R:G132	4.52	0	Yes	No	5	5	2	2
R:R:E157	R:R:F134	11.66	0	Yes	Yes	8	5	1	2
R:R:F134	R:R:T159	7.78	0	Yes	No	5	5	2	2
R:R:D160	R:R:N135	5.39	11	Yes	Yes	8	8	1	1
R:R:D151	R:R:F153	3.58	0	No	No	4	5	2	1
R:R:E178	R:R:I152	6.83	0	No	No	5	3	2	1
R:R:E157	R:R:K183	8.1	0	Yes	No	8	6	1	2
R:R:D160	R:R:T159	11.56	11	Yes	No	8	5	1	2
R:R:D160	R:R:N186	5.39	11	Yes	No	8	7	1	2
R:R:P162	R:R:Y163	6.95	0	No	No	7	4	1	2
R:R:D203	R:R:T179	4.34	0	No	No	6	5	1	2
R:R:K183	R:R:Y206	5.97	0	No	Yes	6	6	2	2
R:R:K209	R:R:N186	5.6	0	Yes	No	7	7	1	2
R:R:N208	R:R:Y206	3.49	5	Yes	Yes	5	6	2	2
R:R:L230	R:R:Y206	4.69	0	No	Yes	4	6	1	2
R:R:D232	R:R:Y206	5.75	5	Yes	Yes	9	6	2	2
R:R:K209	R:R:N208	8.39	0	Yes	Yes	7	5	1	2
R:R:D232	R:R:N208	8.08	5	Yes	Yes	9	5	2	2
R:R:K209	R:R:Q235	5.42	0	Yes	No	7	4	1	2
R:R:E251	R:R:L230	7.95	0	No	No	5	4	1	1
R:R:D232	R:R:S234	7.36	5	Yes	No	9	9	2	2
R:R:D232	R:R:I253	16.79	5	Yes	Yes	9	4	2	1
R:R:I253	R:R:S234	4.64	5	Yes	No	4	9	1	2
R:R:R255	R:R:S234	3.95	0	No	No	4	9	2	2
R:R:E251	R:R:R274	9.3	0	No	No	5	3	1	1
R:R:D276	R:R:I253	4.2	5	Yes	Yes	4	4	1	1
R:R:D276	R:R:R255	17.87	5	Yes	No	4	4	1	2
R:R:D276	R:R:R274	7.15	5	Yes	No	4	3	1	1
R:R:E297	R:R:R293	4.65	0	No	No	5	4	1	2
R:R:C390	R:R:R293	5.57	0	No	No	9	4	2	2
R:R:L296	R:R:M300	7.07	3	Yes	No	4	3	1	1
R:R:C390	R:R:I389	3.27	0	No	No	9	4	2	1
R:R:D203	R:R:T181	2.89	0	No	No	6	7	1	2
R:R:D276	R:R:T399	2.89	5	Yes	Yes	4	4	1	2
R:R:R112	R:R:V87	2.62	0	No	No	6	4	2	1
R:R:R80	R:R:T104	2.59	2	Yes	No	4	5	1	2
M:M:A46	R:R:T388	1.68	0	No	No	0	4	0	1
M:M:A46	R:R:I389	1.62	0	No	No	0	4	0	1
R:R:K250	R:R:S229	1.53	0	No	No	7	5	2	1
M:M:F41	R:R:G294	1.51	0	No	No	0	5	0	1
R:R:K209	R:R:K211	1.44	0	Yes	No	7	3	1	2
L:L:M29	R:R:D382	1.39	0	No	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7T9I_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.9
Number of Linked Nodes	753
Number of Links	876
Number of Hubs	125
Number of Links mediated by Hubs	437
Number of Communities	32
Number of Nodes involved in Communities	156
Number of Links involved in Communities	195

Path Summary
Number Of Nodes in MetaPath	91
Number Of Links MetaPath	90
Number of Shortest Paths	1462330
Length Of Smallest Path	3
Average Path Length	37.1249
Length of Longest Path	66
Minimum Path Strength	1.31
Average Path Strength	5.51256
Maximum Path Strength	17.285
Minimum Path Correlation	0.71
Average Path Correlation	0.986716
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.5641
Average % Of Corr. Nodes	47.5139
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.1085
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• regulation of biological process • cell population proliferation • regulation of cellular process • positive regulation of cell population proliferation • regulation of cell population proliferation • biological regulation • positive regulation of biological process • cellular process • positive regulation of cellular process • multicellular organismal process • system process • gonadotropin secretion • transport • signaling • hormone secretion • cell communication • localization • secretion by cell • signal release • regulation of biological quality • secretion • regulation of hormone levels • follicle-stimulating hormone secretion • cell-cell signaling • export from cell • establishment of localization • endocrine hormone secretion • endocrine process • hormone transport • phenol-containing compound metabolic process • modified amino acid metabolic process • metabolic process • hormone metabolic process • thyroid hormone generation • thyroid hormone metabolic process • developmental process • developmental growth • growth • organ growth • multicellular organism development • thyroid gland development • endocrine system development • gland development • animal organ development • anatomical structure development • system development • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • cellular response to stimulus • response to stimulus • response to endogenous stimulus • hormone-mediated signaling pathway • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • signal transduction • cellular response to hormone stimulus • regulation of signaling • regulation of signaling receptor activity • regulation of signal transduction • regulation of molecular function • regulation of response to stimulus • regulation of cell communication • regulation of steroid biosynthetic process • steroid metabolic process • regulation of lipid metabolic process • lipid biosynthetic process • regulation of primary metabolic process • positive regulation of metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • steroid biosynthetic process • regulation of biosynthetic process • regulation of steroid metabolic process • primary metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • positive regulation of lipid biosynthetic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • regulation of metabolic process • lipid metabolic process • G protein-coupled receptor signaling pathway • regulation of growth • regulation of developmental growth • regulation of developmental process • negative regulation of developmental process • negative regulation of biological process • negative regulation of organ growth • negative regulation of developmental growth • negative regulation of growth • regulation of organ growth • regulation of multicellular organismal process • negative regulation of multicellular organismal process • luteinizing hormone secretion • ovulation cycle process • reproductive process • sex differentiation • development of primary female sexual characteristics • developmental process involved in reproduction • ovulation cycle • development of primary sexual characteristics • reproductive structure development • ovarian follicle development • rhythmic process • gonad development • reproductive system development • female gonad development • multicellular organismal reproductive process • female sex differentiation • follicle-stimulating hormone signaling pathway • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • membrane-bounded organelle • intracellular anatomical structure • Golgi apparatus • membrane-enclosed lumen • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle lumen • Golgi lumen • intracellular organelle • cellular anatomical structure • organelle lumen • organelle • cytoplasm • protein-containing complex
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • Golgi apparatus • membrane-enclosed lumen • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle lumen • Golgi lumen • intracellular organelle • cellular anatomical structure • organelle lumen • organelle • cytoplasm • protein-containing complex • extracellular region • pituitary gonadotropin complex • extracellular space • follicle-stimulating hormone complex • molecular transducer activity • binding • molecular function activator activity • signaling receptor binding • signaling receptor activity • signaling receptor activator activity • hormone activity • protein binding • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • response to stimulus • response to hormone • response to endogenous stimulus • response to chemical • response to estrogen • response to metal ion • response to calcium ion • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • cell-cell signaling • response to nutrient levels • response to lipid • response to nutrient • response to vitamin A • response to vitamin • developmental process • anatomical structure morphogenesis • anatomical structure development • protein-hormone receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • thyroid-stimulating hormone receptor activity • protein-containing complex binding • peptide receptor activity • G protein-coupled peptide receptor activity • cellular response to nitrogen compound • response to peptide hormone • response to oxygen-containing compound • cellular response to peptide hormone stimulus • response to nitrogen compound • cellular response to thyrotropin-releasing hormone • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to thyrotropin-releasing hormone • cellular response to hormone stimulus • hormone-mediated signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to glycoprotein • cellular response to glycoprotein • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • multicellular organismal process • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • cell surface receptor signaling pathway • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • thyroid-stimulating hormone signaling pathway • cell surface • cell periphery • plasma membrane • membrane • basal part of cell • basal plasma membrane • plasma membrane region • basolateral plasma membrane • receptor complex • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • response to glucagon • cellular response to glucagon stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • vesicle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Cystine-knot cytokines • L domain-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Cystine-knot cytokines • L domain-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P16473
Sequence	>7T9I_nogp_Chain_R T M G C S S P P C E C H Q E E D F R V T C K D I Q R I P S L P P S T Q T L K L I E T H L R T I P S H A F S N L P N I S R I Y V S I D V T L Q Q L E S H S F Y N L S K V T H I E I R N T R N L T Y I D P D A L K E L P L L K F L G I F N T G L K M F P D L T K V Y S T D I F F I L E I T D N P Y M T S I P V N A F Q G L C N E T L T L K L Y N N G F T S V Q G Y A F N G T K L D A V Y L N K N K Y L T V I D K D A F G G V Y S G P S L L D V S Q T S V T A L P S K G L E H L K E L I A R N T W T L K K L P L S L S F L H L T R A D L S Y P S H C C A F K N Q K K I R G I L E S L M C N E S S A F D S H Y D Y T I C G D S E D M V C T P K S D E F N P C E D I M G Y K F L R I V V W F V S L L A L L G N V F V L L I L L T S H Y K L N V P R F L M C N L A F A D F C M G M Y L L L I A S V D L Y T H S E Y Y N H A I D W Q T G P G C N T A G F F T V F A S E L S V Y T L T V I T L E R W Y A I T F A M R L D R K I R L R H A C A I M V G G W V C C F L L A L L P L V G I S S Y A K V S I C L P M D T E T P L A L A Y I V F V L T L N I V A F V I V C C C Y V K I Y I T V R N D T K I A K R M A V L I F T D F I C M A P I S F Y A L S A I L N K P L I T V S N S K I L L V L F Y P L N S C A N P F L Y A I F T K A F Q R D V F I L L S K F G I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XW5	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TSH	ML109	Gs/β1/γ2	2.96	2022-08-24	10.1038/s41586-022-05173-3
	7XW5 (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TSH	ML109		2.96	2022-08-24	10.1038/s41586-022-05173-3
	7XW7	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	K1-70	-	-	5.5	2022-08-17	10.1038/s41586-022-05173-3
	7XW6	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	ML109	Gs/β1/γ2	2.78	2022-08-17	10.1038/s41586-022-05173-3
	7XW6 (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	ML109		2.78	2022-08-17	10.1038/s41586-022-05173-3
	7T9M	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	-	CS-17 Antibody	-	3.1	2022-08-10	10.1038/s41586-022-05159-1
	7UTZ	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TR1402	PubChem 644078	Gs/β1/γ2	2.4	2022-08-03	10.1038/s41586-022-05159-1
	7UTZ (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TR1402	PubChem 644078		2.4	2022-08-03	10.1038/s41586-022-05159-1
	7T9N	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	PubChem 644078	Gs/β1/γ2	2.9	2022-08-03	10.1038/s41586-022-05159-1
	7T9N (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	PubChem 644078		2.9	2022-08-03	10.1038/s41586-022-05159-1
	7T9I	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TSH	-	Gs/β1/γ2	2.9	2022-08-03	10.1038/s41586-022-05159-1
	7T9I (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TSH	-		2.9	2022-08-03	10.1038/s41586-022-05159-1

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