Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1b.1x4 3.225188
2b.1x7 4.0654188
3b.1x11 2.40375408
4b.1x15 3.54407
5b.lhb1x3 3.6215122
6b.lhb1x6 4.0695123
7b.lhb1x11 4.07875404
8b.l1x3 8.61667639
9b.l1x6 9.70625419
10b.b2x1 6.555518
11b.b2x3 3.636536
12b.b2x5 7.074537
13b.b3x3 4.533754108
14b.l3x2 5.06143739
15b.b4x3 4.425836107
16b.b4x6 9.13214739
17b.l4x2 10.43634
18b.b5x3 5.51929739
19b.b5x5 4.52875405
20b.b5x7 5.82875407
21b.l5x1 4.9454108
22b.l5x5 8.7925619
23b.b6x1 5.31125409
24b.b6x5 4.3506
25b.b7x1 6.11404
26b.b7x4 3.893754108
27b.b8x3 3.3195206
28b.b8x4 6.0975106
29b.b9x3 4.3225406
30b.l9x3 7.03833619
31b.l9x6 6.06571718
32b.b10x5 4.956509
33b.b11x4 5.95419
34b.l11x2 8.5775419
35b.b12x6 7.76286718
36b.b13x7 8.219557
37b.l13x3 8.24083659
38b.l13x6 5.305419
39b.b15x1 7.11559
40b.b15x2 7.40625446
41b.l15x1 6.31417
42b.l15x2 7.5625459
43b.b16x4 10.7638456
44b.b16x5 4.0175405
45b.b16x6 8.2325658
46b.b16x7 6.255409
47b.b17x5 7.64125447
48b.b17x7 8.59625448
49b.l17x3 8.91649
50b.l17x6 7.836519
51b.b18x3 5.09375448
52b.b18x5 6.5925405
53b.l18x1 8.205836116
54b.l18x2 7.641254117
55b.l18x3 8.328754115
56b.b19x2 7.05917646
57b.b19x4 5.44875448
58b.l19x1 6.36419
59b.l19x2 6.758549
60b.b20x4 9.46917648
61b.b20x6 6.62583646
62b.b21x1 8.765447
63b.b21x2 4.35406
64b.b21x3 8.88875446
65b.b21x5 5.9175404
66b.b21x7 6.63605
67b.l21x2 6.43375404
68b.l21x5 3.616254134
69b.b22x5 4.638336117
70b.l22x5 6.9785129
71b.b23x6 8.9585137
72b.l23x1 6.543516
73b.b24x4 7.1365136
74b.b24x6 6.188754138
75b.l24x2 4.44254126
76b.l24x3 4.09375405
77b.l25x3 8.302599
78b.l25x6 14.17518
79b.l26x5 5.56625405
80b.l27x1 11.4264719
81b.l27x2 8.9575499
82b.b28x2 6.01625404
83b.b28x3 4.65667637
84b.b28x4 7.42125496
85b.b28x6 10.295599
86b.b28x7 7.32125439
87G.S1.02 5.40625466
88G.S1.06 5.58254218
89G.S2.01 3.62419
90G.S3.01 7.2875466
91G.S3.04 7.005417
92G.S3.05 4.30375408
93G.S3.06 8.316516
94G.S3.07 3.97754219
95G.s3h2.03 5.8625419
96G.H2.04 5.0325419
97G.H2.06 6.005619
98G.H2.07 6.47667619
99G.H2.09 5.10375418
100G.h2s4.01 7.534519
101G.h2s4.02 5.245418
102G.S4.02 4.57375418
103G.S4.03 3.465408
104G.S4.04 4.837509
105G.s4h3.01 5.3025407
106G.H3.03 3.6725404
107G.H3.06 4.931254156
108G.H3.09 6.4275229
109G.H3.13 6.6435226
110G.H3.17 8.91571715
111G.H3.18 4.316519
112G.S5.03 3.54409
113G.S5.04 4.925409
114G.S5.05 5.9065169
115G.HG.01 4.046586
116G.hgh4.02 4.222867158
117G.hgh4.05 6.55406
118G.H4.03 3.53484
119G.H4.05 3.54375405
120G.H4.10 9.193754156
121G.H4.12 7.5425485
122G.H4.14 6.298754156
123G.H4.15 7.81375408
124G.S6.02 6.652578
125G.S6.04 6.85125409
126G.S6.05 6.46585
127G.s6h5.01 7.048754169
128G.H5.03 7.731254169
129G.H5.08 5.749569
130G.H5.17 5.689576
131G.H5.20 4.0975408
132G.H5.25 4.153509
133G.H5.26 5.13667677
134g.h1x11 2.275409
135g.l1x4 5.7175448
136g.h2x11 9.068754116
137g.ctx3 6.537509
138g.ctx14 9.50375439
139g.ctx15 6.895439
140g.ctx16 5.52938838
141g.ctx17 9.03125407
1421x46 3.4325407
1431x57 4.743754177
1442x40 6.868754179
1452x42 4.422508
1462x46 5.92254149
1472x50 7.3845149
148E1x50 6.37333627
149E1x52 5.29405
1503x28 7.2375426
1513x32 10.19427
1523x33 5.63875426
1533x34 4.17425
1543x37 5.4275406
1553x49 6.526254269
1563x50 8.3575409
1573x51 7.741254288
158I2x51 6.62083666
1594x50 4.155409
1604x58 4.97917625
1614x61 6.755426
162E2.W182 4.389525
163E2.R183 13.1975424
164E2.D184 3.596524
165E2.Y193 8.11125423
166E2x52 7.39375424
167E2.T203 3.29375424
1685x39 5.06667627
1695x47 8.45417627
1705x58 4.73286729
1715x60 6.238754285
1726x29 5.51476
1736x44 6.0875429
1746x48 7.69714728
1756x49 5.1975407
1766x51 9.22583627
1776x52 9.32833627
1786x54 4.62375424
1796x55 5.66375426
180E3.V320 3.811525
1817x34 7.24625424
1827x39 5.447526
1837x42 8.97527
1847x49 6.9725149
1857x53 5.556254149
1868x50 7.174176178
187Lig 8.710671520
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.1x10 b.1x9 12.19091.275NoNo014
2b.1x10 b.1x11 13.55351.33NoYes018
3b.1x11 b.1x7 13.46591.99YesYes088
4b.1x15 g.h1x11 35.13512.14YesYes079
5b.1x11 g.h1x11 31.06232.77YesYes089
6b.1x15 b.1x19 13.53533.135YesNo076
7b.1x15 g.l1x4 27.02865.635YesYes078
8b.1x19 b.b21x1 15.776810.12NoYes067
9b.b21x1 g.l1x4 14.41648.34YesYes478
10b.b17x5 b.b21x1 30.630912.4YesYes477
11b.b16x5 b.b17x5 45.50863.99YesYes057
12b.b15x2 b.b16x5 50.24524.47YesYes065
13b.b15x2 b.b18x5 63.08511.145YesYes065
14b.b18x5 b.l18x4 64.353.01YesNo057
15b.l18x3 b.l18x4 65.19162.545YesNo057
16b.l18x1 b.l18x3 67.970510.27YesYes1165
17b.b22x5 b.l18x1 71.37847.5YesYes1176
18b.b22x5 b.b23x2 75.56736.7YesNo076
19b.b21x7 b.b23x2 75.97894.69YesNo056
20b.b21x5 b.b21x7 85.290910.18YesYes045
21g.l1x2 g.l1x4 14.41477.515NoYes428
22b.b17x5 g.l1x2 14.86234.805YesNo472
23b.b21x5 b.h2x1 88.91256.36YesNo045
24b.h2x1 b.h2x5 91.48072.95NoNo055
25b.h2x5 b.l24x2 91.87972.95NoYes056
26b.l22x5 b.l24x2 92.27947.285YesYes1296
27b.l22x5 b.lhb1x6 90.69375.885YesYes1293
28b.lhb1x6 b.lhb1x9 95.06633.07YesNo033
29b.lhb1x11 b.lhb1x9 95.79482.92YesNo043
30b.b28x7 b.lhb1x11 15.6214.21YesYes094
31b.b25x7 b.lhb1x11 1004.945NoYes074
32b.b25x7 b.b28x6 57.70319.93NoYes079
33b.b28x4 b.b28x6 29.70058.12YesYes969
34b.b28x7 g.ctx16 12.18354.225YesYes398
35b.b2x5 b.l4x1 21.38864.94YesNo375
36b.b2x3 b.b2x5 21.47084.65YesYes367
37b.b27x3 b.b28x6 29.69929.095NoYes089
38b.b27x3 b.l25x3 36.22756.845NoYes089
39b.l25x3 b.l27x2 64.251410.715YesYes999
40b.b28x4 b.l25x3 29.42236.55YesYes969
41b.b24x3 b.b25x7 42.60037.94NoNo057
42b.b24x3 b.b26x3 43.02433.17NoNo056
43b.b22x2 b.b26x3 51.55846.005NoNo086
44b.b22x1 b.b22x2 51.74184.8NoNo088
45b.b22x1 b.l25x6 30.39833.88NoYes188
46G.H2.09 b.b2x1 12.61833.81YesYes188
47G.H3.17 b.l25x6 21.425614.995YesYes158
48G.H3.17 b.l23x1 22.0334.465YesYes156
49b.b22x1 b.l23x1 21.5534.34NoYes186
50b.b2x1 b.b6x1 14.97415.39YesYes089
51b.b26x2 b.b2x3 23.22394.86NoYes076
52b.b6x1 b.l9x6 16.86327.785YesYes098
53b.l11x1 b.l9x6 25.1327.24NoYes198
54b.b11x6 b.l11x1 25.03733.71NoNo199
55b.b11x6 b.l9x3 23.436714.645NoYes199
56b.b11x4 b.l9x3 12.98726.165YesYes199
57b.b10x3 b.b11x4 13.01023.38NoYes089
58b.b10x3 b.b6x2 12.74113.38NoNo088
59b.b10x2 b.b6x2 12.47173.38NoNo068
60b.b10x2 b.b14x3 12.2025.555NoNo065
61b.l2x5 b.l4x2 25.360428.295NoYes354
62b.l2x3 b.l2x5 25.35924.165NoNo085
63b.b3x1 b.l2x3 25.07878.82NoNo058
64b.b3x1 b.b6x5 18.30754.69NoYes056
65b.b3x3 b.b6x5 17.16585.05YesYes086
66b.b3x3 b.b4x3 16.29864.47YesYes1087
67G.S1.03 G.S3.06 10.89466.485NoYes096
68G.S1.03 G.hns1.01 10.73889.775NoNo093
69G.H2.07 b.l9x6 15.23014.825YesYes198
70G.H2.08 G.H3.18 60.72543.225NoYes199
71G.H3.15 G.H3.18 59.63726.535NoYes089
72G.H3.15 G.H3.17 59.62974.52NoYes085
73b.l25x4 b.l27x2 63.1364.655NoYes059
74b.b26x1 b.b26x2 23.29863.44NoNo097
75G.H5.17 G.S6.02 12.87388.645YesYes768
76G.S6.02 G.h4s6.12 16.75853.93YesNo082
77G.h3s5.02 G.h4s6.12 50.30213.235NoNo042
78G.h3s5.02 G.h3s5.03 50.42092.965NoNo047
79G.H3.18 G.h3s5.03 47.59753.31YesNo197
80G.H5.10 G.S6.02 15.518810.14NoYes078
81G.H2.04 G.H2.08 52.26243.13YesNo199
82G.H2.04 G.H3.08 64.26716.68YesNo099
83G.H3.08 G.S4.04 64.07117.31NoYes099
84G.S4.04 G.S4.06 13.27963.275YesNo097
85G.H3.09 G.S4.04 29.08467.505YesYes099
86G.S4.04 G.S5.04 21.57333.655YesYes099
87G.H4.15 G.S4.06 12.80735.245YesNo087
88G.H3.09 G.H4.15 13.002110.72YesYes098
89G.H4.15 G.S5.04 12.99576.7YesYes089
90G.H3.03 G.H3.07 10.70233.955YesNo045
91G.H3.03 G.hgh4.02 17.55032.93YesYes048
92G.H3.06 G.hgh4.02 35.86094.215YesYes1568
93G.H3.06 G.H4.15 37.80798.59YesYes068
94G.H3.06 G.h4s6.01 12.68143.555YesNo065
95G.H3.09 G.h4s6.01 13.16584.335YesNo095
96G.H3.06 G.H4.14 13.62293.365YesYes1566
97G.H4.10 G.hgh4.05 15.689612.385YesYes066
98G.H4.10 G.hgh4.02 11.82164.13YesYes1568
99G.H4.10 G.H4.14 11.671312.01YesYes1566
100G.H5.21 G.h4s6.12 33.46293.73NoNo052
101G.H5.21 G.H5.26 33.31585.56NoYes057
1022x39 3x49 54.87245.06NoYes089
1032x37 2x39 54.843.14NoNo078
1042x37 2x40 54.855710.235NoYes079
1052x40 I1x50 53.83434.12YesNo1798
1061x60 I1x50 57.51726.635NoNo068
1071x60 8x56 57.98715.82NoNo064
1088x56 b.l25x4 58.32235.36NoNo045
109G.H5.20 G.H5.26 40.09043.38YesYes087
110G.H5.20 G.H5.25 39.45244.15YesYes089
111G.H5.23 G.H5.25 12.00574.935NoYes049
1123x50 G.H5.23 11.927416.705YesNo094
1133x46 3x50 38.5914.385NoYes099
1142x42 3x46 38.55663.14YesNo089
1152x42 3x49 55.18555.97YesYes089
1166x37 G.H5.25 27.09154.845NoYes089
1176x48 7x45 25.34986.78YesNo089
1187x45 7x49 25.72019.535NoYes099
1197x49 7x53 29.56093.49YesYes1499
1203x50 7x53 32.31395.655YesYes099
1216x48 6x51 15.09916.015YesYes287
1226x52 Lig 24.00875.985YesYes270
1235x47 6x52 21.482120.36YesYes277
1245x47 6x44 27.49216.97YesYes279
1255x54 6x44 32.60087.465NoYes289
1265x54 5x58 32.77382.995NoYes289
1273x50 5x58 10.48126.685YesYes099
1283x38 4x53 15.3033.42NoNo078
1293x38 4x50 15.52827.78NoYes079
1302x45 4x50 16.21134.94NoYes099
1312x45 4x46 18.75233.87NoNo097
1322x42 4x46 20.5195.02YesNo087
1333x28 Lig 14.7168.92YesYes260
1343x28 E1x50 12.71577.495YesYes267
135E1x50 E1x52 10.05138.905YesYes075
136E2.R183 E2.W182 14.62594.5YesYes245
137E2.W182 E2x52 10.71973.005YesYes254
138E2x52 Lig 15.360819.44YesYes240
139E2.R183 E2.Y193 10.775421.09YesYes243
140b.b26x1 b.l27x1 23.37534.94NoYes099
141G.H3.17 b.l27x1 16.22675.155YesYes159
1425x58 6x37 26.28224.69YesNo098
143b.l4x1 b.l4x2 15.79243.815NoYes354
144G.H2.04 G.H2.07 12.41339YesYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
1x397x3911.050NoYes6621
2x563x327.32NoYes7721
2x567x423.792NoYes7721
2x577x393.0650NoYes7621
2x59E1x504.012NoYes4722
2x593x289.022NoYes4621
2x603x283.5150NoYes6621
2x63Lig3.680NoYes5010
2x647x393.0650NoYes5621
3x28E1x507.4952YesYes6712
3x28Lig8.922YesYes6010
3x29E2x523.240NoYes6421
3x323x363.652YesNo7611
3x327x4213.2152YesYes7711
3x32Lig16.5952YesYes7010
3x334x573.232YesNo6712
3x334x613.072YesYes6612
3x335x393.1552YesYes6712
3x33Lig13.12YesYes6010
3x366x489.812NoYes6812
3x36Lig6.7152NoYes6010
3x375x4618.790YesNo6621
4x61E2.W1826.462YesYes6022
4x615x396.652YesYes6722
E2.W182E2x523.0052YesYes0421
E2.T203E2.W1823.642YesYes0022
5x39E2.W1824.342YesYes7022
E2.T203E2x523.892YesYes0421
E2x52Lig19.442YesYes4010
5x39E2.T2033.1252YesYes7022
5x395x438.2652YesNo7621
5x43Lig7.380NoYes6010
5x446x524.620NoYes6721
5x446x555.960NoYes6621
5x4616x524.6252NoYes6711
5x461Lig4.3252NoYes6010
5x476x484.512YesYes7822
5x476x5220.362YesYes7721
6x486x516.0152YesYes8721
6x486x527.522YesYes8721
6x516x5212.862YesYes7711
6x516x556.042YesYes7611
6x517x348.0352YesYes7412
6x517x3813.8952YesNo7611
6x51Lig8.512YesYes7010
6x52Lig5.9852YesYes7010
6x557x346.042YesYes6412
6x55Lig4.6152YesYes6010
7x35Lig3.960NoYes4010
7x387x4213.9552NoYes6711
7x38Lig16.032NoYes6010
7x397x426.272YesYes6711
7x39Lig3.7852YesYes6010
7x42Lig7.622YesYes7010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6H7LDobutamine6H7L-β1-Dobutamine
100.00Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
88.24Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
86.67Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
86.67Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
86.67Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
81.25Single4LDEBI1671074LDE-β2-BI167107
81.25Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
81.25Single8JJ8Formoterol8JJ8-β2-Formoterol
81.25Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
81.25Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
80.00Single2Y00Dobutamine2Y00-β1-Dobutamine
80.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
80.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
80.00Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
80.00Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
80.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
80.00Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
80.00Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
80.00Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
80.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
80.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
77.78Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
76.47Single6IBLArformoterol6IBL-β1-Arformoterol
76.47Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
75.00Single3P0GBI1671073P0G-β2-BI167107
75.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
75.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
75.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
75.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
75.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
75.00Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
75.00Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
73.33Single2Y01Dobutamine2Y01-β1-Dobutamine
73.33Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
73.33Single4QKX35V4QKX-β2-35V
73.33Single6H7MSalbutamol6H7M-β1-Salbutamol
73.33Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
73.33Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
73.33Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
73.33Single7BU7BI1671077BU7-β1-BI167107
73.33Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
73.33Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
73.33Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
73.33Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
73.33Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
73.33Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
73.33Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
73.33Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
73.33Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
73.33Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
73.33Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
73.33Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
73.33Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
73.33Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
73.33Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
73.33Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
73.33Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
73.33Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
73.33Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
73.33Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
73.33Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
73.33Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
73.33Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
73.33Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
73.33Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
73.33Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
72.22Single8X5YAstemizole8X5Y-H1-Astemizole
70.59Single4AMIBucindolol4AMI-β1-Bucindolol
70.59Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
70.59Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
70.59Single8JJLOlodaterol8JJL-β2-Olodaterol
70.59Consensusalpha1_offOrthosteric Ligandalpha1a_off
70.59Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
70.59Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
70.59Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
68.75Single2RH1S-Carazolol2RH1-β2-S-Carazolol
68.75Single2Y03Isoprenaline2Y03-β1-Isoprenaline
68.75Single5JQHS-Carazolol5JQH-β2-S-Carazolol
68.75Single5WIUNemonapride5WIU-D4-Nemonapride
68.75Single5WIVNemonapride5WIV-D4-Nemonapride-Na
68.75Single7WC6LSD7WC6-5-HT2A-LSD
68.75Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
68.75Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
68.75Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
68.75Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
68.75Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
68.75Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
68.75Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
68.75Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
68.75Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
68.75Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
68.75Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
68.75Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
68.75Consensusamine_offonOrthosteric Ligandamine_off amine_on
68.75Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
68.75Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
68.75Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
68.75Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
68.75Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
68.75Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
68.42Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
66.67Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
66.67Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
66.67Single6PS0S-Carazolol6PS0-β2-S-Carazolol
66.67Single6PS4ICI118-5516PS4-β2-ICI118-551
66.67Single6PS5S-Propranolol6PS5-β2-S-Propranolol
66.67Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
66.67Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
66.67Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
66.67Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
66.67Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
66.67Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
66.67Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
66.67Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
66.67Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
66.67Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
66.67Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
66.67Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
66.67Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
66.67Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
66.67Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
66.67Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
66.67Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
66.67Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
66.67Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
64.71Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
64.71Single5D5AS-Carazolol5D5A-β2-S-Carazolol
64.71Single5D5BS-Carazolol5D5B-β2-S-Carazolol
64.71Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
64.71Single6WGTLSD6WGT-5-HT2A-LSD
64.71Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
64.71Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
64.71Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
64.71Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
64.71Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
64.71Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
64.71Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
64.71Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
64.71Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
64.71Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
64.71Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
64.71Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
62.50Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
62.50Single2Y02Carmoterol2Y02-β1-Carmoterol
62.50Single2Y04Salbutamol2Y04-β1-Salbutamol
62.50Single3NY8ICI118-5513NY8-β2-ICI118-551
62.50Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
62.50Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
62.50Single4GBRS-Carazolol4GBR-β2-S-Carazolol
62.50Single6PS1Timolol6PS1-β2-Timolol
62.50Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
62.50Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
62.50Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
62.50Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
62.50Single7WC7Lisuride7WC7-5-HT2A-Lisuride
62.50Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
62.50Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
62.50Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
62.50Single8JJOAlprenolol8JJO-β2-Alprenolol
62.50Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
62.50Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
62.50Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
62.50Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
62.50Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
62.50Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
62.50Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
62.50Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
62.50Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
62.50Consensus5ht5_onOrthosteric Ligand5ht5a_on
62.50Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
62.50Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
62.50Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
62.50Consensusdopamine_offOrthosteric Ligandd2_off d3_off
61.11Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
61.11Single3D4STimolol3D4S-β2-Timolol
61.11Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
61.11Single6MXTSalmeterol6MXT-β2-Salmeterol
61.11Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
61.11Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
61.11Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
61.11Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
61.11Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
61.11Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
61.11Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
61.11Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
60.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
60.00Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
60.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
60.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
60.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
60.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
60.00Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
60.00Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
60.00Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
60.00Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
60.00Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
60.00Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
60.00Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
60.00Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
60.00Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
60.00Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
60.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
60.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
60.00Consensusalpha2_offOrthosteric Ligandalpha2c_off
60.00Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
58.82Single2YCWS-Carazolol2YCW-β1-S-Carazolol
58.82Single5D6LS-Carazolol5D6L-β2-S-Carazolol
58.82Single5TVNLSD5TVN-5-HT2B-LSD
58.82Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
58.82Single7C61Ergotamine7C61-5-HT1B-Ergotamine
58.82Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
58.82Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
58.82Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
58.82Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
58.82Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
58.82Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
58.82Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
58.82Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
58.82Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
58.82Consensustrace-amine_onOrthosteric Ligandta1_on
57.89Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
57.89Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
57.89Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
56.25Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
56.25Single6KUXRS-799486KUX-α2a-RS-79948
56.25Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
56.25Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
56.25Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
56.25Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
56.25Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
56.25Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
56.25Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
56.25Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
56.25Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
56.25Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
56.25Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
56.25Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
56.25Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
56.25Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
56.25Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
56.25Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
56.25Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
56.25Consensusalpha1_onOrthosteric Ligandalpha1a_on
56.25Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
56.25Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
56.25Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
55.56Single2YDVNECA2YDV-A2A-NECA
55.56Single4UHRCGS216804UHR-A2A-CGS21680
55.56Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
55.56Single5G53NECA5G53-A2A-NECA-Gs
55.56Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
55.56Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
55.56Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
55.56Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
55.56Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
55.56Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
55.56Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
55.56Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
55.00Single3NY9ICI118-5513NY9-β2-ICI118-551
55.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
53.33Single3PBLEticlopride3PBL-D3-Eticlopride
53.33Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
53.33Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
53.33Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
53.33Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
53.33Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
53.33Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
53.33Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
53.33Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
52.94Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
52.94Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
52.94Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
52.94Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
52.94Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
52.94Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
52.94Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
52.94Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
52.94Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
52.94Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
52.94Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
52.94Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
52.94Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
52.94Single8JXRLSD8JXR-D1-LSD
52.94Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
52.94Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
52.94Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
52.94Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
52.94Single8X64Desloratadine8X64-H1-Desloratadine
52.94Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
52.94Single9CHXS-Carazolol9CHX-β2-S-Carazolol
52.94Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
52.94Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
52.94Consensusalpha2_onOrthosteric Ligandalpha2b_on
52.94Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
52.94Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
52.94Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
52.94Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
52.94Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
52.63Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
52.63Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
52.63Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
52.63Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
52.63Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
52.63Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
52.38Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
52.38Single8WDTphotoNECA8WDT-A2A-photoNECA
52.38Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
50.00Single5C1MBU725C1M-μ-BU72
50.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
50.00Single5X93K-87945X93-ETB-K-8794
50.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
50.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
50.00Single6PS6Timolol6PS6-β2-Timolol
50.00Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
50.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
50.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
50.00Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
50.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
50.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
50.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
50.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
50.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
50.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
50.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
50.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
50.00Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
50.00Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
50.00Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
50.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
50.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
50.00Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
50.00Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
50.00Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
50.00Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
50.00Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
50.00Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
50.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
50.00Consensusendothelin_offOrthosteric Ligandetb_off
50.00Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
50.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
50.00Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
50.00Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
47.62Single4UG2CGS216804UG2-A2A-CGS21680
47.37Single4U15Tiotropium4U15-M3-Tiotropium
47.37Single6J21Aprepitant6J21-NK1-Aprepitant
47.37Single6OL9Tiotropium6OL9-M5-Tiotropium
47.37Single6TQ7SB-3348676TQ7-OX1-SB-334867
47.37Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
47.37Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
47.37Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
47.37Single8E0GBU728E0G-μ-BU72
47.37Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
47.37Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
47.37Single8XVLZibotentan8XVL-ETA-Zibotentan
47.37Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
47.37Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
47.37Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
47.37Consensustachykinin_offOrthosteric Ligandnk1_off
47.06Single6A94Zotepine6A94-5-HT2A-Zotepine
47.06Single6TPGEMPA6TPG-OX2-EMPA
47.06Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
47.06Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
47.06Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
47.06Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
47.06Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
47.06Single7UL3Famotidine7UL3-H2-Famotidine
47.06Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
47.06Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
47.06Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
47.06Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
47.06Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
47.06Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
47.06Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
47.06Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
47.06Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
47.06Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
47.06Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
47.06Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
47.06Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
47.06Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
46.67Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
46.67Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
46.67Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
45.45Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
45.45Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
45.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
45.00Single5CXVTiotropium5CXV-M1-Tiotropium
45.00Single6CM4Risperidone6CM4-D2-Risperidone
45.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
45.00Single7YITNalfurafine7YIT-κ-Nalfurafine
45.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
45.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
45.00Single8JWY2-1188JWY-A2A-2-118
45.00Single8JWZAB9288JWZ-A2A-AB928-Na
45.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
45.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
45.00Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
45.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
45.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
45.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
45.00Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
44.44Single4EJ4Naltrindole4EJ4-δ-Naltrindole
44.44Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
44.44Single5DHGC-355DHG-NOP-C-35
44.44Single5DHHSB-6121115DHH-NOP-SB-612111
44.44Single5UIGCmpd-15UIG-A2A-Cmpd-1
44.44Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
44.44Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
44.44Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
44.44Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
44.44Single6TOTLemborexant6TOT-OX1-Lemborexant
44.44Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
44.44Single7UL4Alvimopan7UL4-μ-Alvimopan
44.44Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
44.44Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
44.44Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
44.44Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
44.44Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
44.44Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
44.44Single8X63Mepyramine8X63-H1-Mepyramine
44.44Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
44.44Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
44.44Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
44.44Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
44.44Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
44.44Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
44.44Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
44.44Consensushistamine_offOrthosteric Ligandh1_off
44.00Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
43.75Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
43.75Single7SRQLSD7SRQ-5-HT2B-LSD
43.75Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
43.75Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
43.75Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
43.75Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
43.75Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
43.75Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
43.75Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
43.75Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
43.75Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
43.75Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
43.75Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
43.75Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
43.75Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
43.48Single3QAKUK-4320973QAK-A2A-UK-432097
43.48Single6HLOAprepitant6HLO-NK1-Aprepitant
43.48Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
43.48Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
43.48Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
42.86Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
42.86Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
42.86Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
42.86Single7EZCUKA7EZC-A2A-UKA
42.86Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
42.86Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
42.86Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
42.86Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
42.86Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
42.86Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
42.86Consensusprostanoid_offOrthosteric Ligandep_off dp_off
42.31Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
42.11Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
42.11Single5WQCEMPA5WQC-OX2-EMPA
42.11Single6LUQHaloperidol6LUQ-D2-Haloperidol
42.11Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
42.11Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
42.11Single6TP6Filorexant6TP6-OX1-Filorexant
42.11Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
42.11Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
42.11Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.11Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
42.11Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.11Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
42.11Single8JXSPF-61428JXS-D1-PF-6142
42.11Single8ZMFA1L108ZMF-5-HT2C-A1L10
42.11Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
42.11Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
42.11Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.11Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.67Single5WF5UK-4320975WF5-A2A-UK-432097
41.67Single6PT2KGCHM076PT2-δ-KGCHM07
41.67Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
41.18Single6AKXA4R6AKX-CCR5-A4R
41.18Single6DS0Ly2660976DS0-5-HT2B-Ly266097
41.18Single6TODEMPA6TOD-OX1-EMPA-Na
41.18Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
41.18Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
41.18Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
41.18Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
41.18Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
41.18Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
41.18Single8IWESpermidine8IWE-TA9-Spermidine
41.18Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
41.18Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
41.18Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
40.91Single5WF6UK-4320975WF6-A2A-UK-432097
40.91Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
40.91Single6PT3DPI-2876PT3-δ-DPI-287
40.91Single7SK9CCX6627SK9-ACKR3-CCX662
40.91Single7XN9L-054,5227XN9-SST2-L-054,522
40.91Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
40.91Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
40.91Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.91Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single4DJHJDTic4DJH-κ-JDTic
40.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
40.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
40.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
40.00Single6J20Aprepitant6J20-NK1-Aprepitant
40.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
40.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
40.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
40.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
40.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
40.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
40.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
40.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
40.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Single8EA0Iperoxo8EA0-M3-Iperoxo
40.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
40.00Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
40.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
40.00Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
40.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
40.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
40.00Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
40.00Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
40.00Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
40.00Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single9CHUNoradrenaline9CHU-β2-Noradrenaline
40.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
40.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
40.00Consensusa2_onOrthosteric Liganda2b_on
40.00Consensusa2_on_gpOrthosteric Liganda2b_on_gp
40.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
40.00Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
40.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
40.00Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
40.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
40.00Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
40.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
40.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
39.13Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
39.13Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
39.13Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
38.89Single2YDOAdenosine2YDO-A2A-Adenosine
38.89Single3RZECidoxepin3RZE-H1-Cidoxepin
38.89Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
38.89Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
38.89Single4MBSMaraviroc4MBS-CCR5-Maraviroc
38.89Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
38.89Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
38.89Single4ZJCSB-6740424ZJC-OX1-SB-674042
38.89Single6IQLL7458706IQL-D4-L745870
38.89Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
38.89Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
38.89Single6TPNHTL66416TPN-OX2-HTL6641
38.89Single6VI4JDTic6VI4-κ-JDTic
38.89Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
38.89Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
38.89Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
38.89Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
38.89Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
38.89Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
38.89Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.89Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
38.89Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
38.89Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
38.89Single9BJKNaloxone9BJK-μ-Naloxone-NAM
38.89Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
38.89Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
38.89Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
38.46Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
38.10Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
38.10Single6A93Risperidone6A93-5-HT2A-Risperidone
38.10Single6ZG4HTL00099366ZG4-M1-HTL0009936
38.10Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
38.10Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
38.10Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
38.10Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
38.10Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
38.10Consensusorexin_onOrthosteric Ligandox2_on
37.50Single3UZAGTPL92363UZA-A2A-GTPL9236
37.50Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
37.50Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
37.50Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
37.50Single7WC5Psilocin7WC5-5-HT2A-Psilocin
37.50Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
37.50Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
37.50Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
37.50Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
37.50Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
37.50Consensus5ht2_onOrthosteric Ligand5ht2b_on
37.50Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
37.50Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
37.50Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
37.50Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
37.50Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
36.84Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
36.84Single4DAJTiotropium4DAJ-M3-Tiotropium
36.84Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
36.84Single4MQSIperoxo4MQS-M2-Iperoxo
36.84Single4U14Tiotropium4U14-M3-Tiotropium
36.84Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
36.84Single5DSGTiotropium5DSG-M4-Tiotropium
36.84Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
36.84Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
36.84Single6DRXLisuride6DRX-5-HT2B-Lisuride
36.84Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.84Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
36.84Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
36.84Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
36.84Single8CU6LJ-45178CU6-A2A-LJ-4517
36.84Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
36.84Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
36.84Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
36.84Single8RLNLUF58348RLN-A2A-LUF5834
36.84Single8T1WCVN4248T1W-GPR6-CVN424
36.84Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
36.84Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
36.84Consensusa3_onOrthosteric Liganda3a_on
36.84Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
36.84Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
36.84Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
36.36Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
36.36Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
36.36Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
36.36Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
36.36Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
36.36Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
36.36Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.36Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.36Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
36.36Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
36.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
36.00Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
36.00Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.00Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
36.00Consensusangiotensin_onOrthosteric Ligandat1_on
36.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
36.00Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
36.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
36.00Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
36.00Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
36.00Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
35.71Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
35.71Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
35.71Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
35.29Single6HLLCP999946HLL-NK1-CP99994
35.29Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
35.29Single6TP4ACT-4622066TP4-OX1-ACT-462206
35.29Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
35.29Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
35.29Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
35.29Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.29Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
35.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
35.00Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
35.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
35.00Single5XPRBosentan5XPR-ETB-Bosentan
35.00Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
35.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
35.00Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
35.00Single6HLPNetupitant6HLP-NK1-Netupitant
35.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
35.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
35.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
35.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
35.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
35.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
35.00Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
35.00Single8TF5Oleic acid8TF5-GPR6-Oleic acid
35.00Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
35.00Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
35.00Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
35.00Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
35.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
35.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
35.00Consensusa3_on_gpOrthosteric Liganda3a_on_gp
35.00Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
35.00Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
35.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
35.00Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
35.00Consensusdp_offOrthosteric Liganddp2_off
34.78Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
34.78Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
34.78Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
34.78Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
34.78Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
34.78Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
34.62Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
34.62Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.62Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
34.62Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
34.62Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
34.62Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.62Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
34.62Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.62Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
34.62Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.62Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
34.62Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
34.62Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
34.62Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
34.62Consensusvasop-oxy_onOrthosteric Ligandv2_on
34.62Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
34.48Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
34.48Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
34.48Consensusbradykinin_onOrthosteric Ligandbk2_on
34.48Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
34.48Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
33.33Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
33.33Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
33.33Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
33.33Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
33.33Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
33.33Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
33.33Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
33.33Single5WS3EMPA5WS3-OX2-EMPA
33.33Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
33.33Single6AKYMaraviroc6AKY-CCR5-Maraviroc
33.33Single6B73MP11046B73-κ-MP1104
33.33Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
33.33Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
33.33Single6E59L-7607356E59-NK1-L-760735
33.33Single6ME2Ramelteon6ME2-MT1-Ramelteon
33.33Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
33.33Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
33.33Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
33.33Single7F8XNN90567F8X-CCKA-NN9056
33.33Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
33.33Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
33.33Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
33.33Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
33.33Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
33.33Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
33.33Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
33.33Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
33.33Single7XRRLemborexant7XRR-OX2-Lemborexant
33.33Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
33.33Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
33.33Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
33.33Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
33.33Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
33.33Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
33.33Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
33.33Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
33.33Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
33.33Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
33.33Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
33.33Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
33.33Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
33.33Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
33.33Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
33.33Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33Single9BJKNAM9BJK-μ-Naloxone-NAM
33.33Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
33.33Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
33.33Consensusbombesin_onOrthosteric Ligandbb2_on
33.33Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
33.33Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
33.33Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
33.33Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
33.33Consensuslpl_onOrthosteric Ligands1p_on lpa_on
33.33Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
33.33Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
33.33Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
33.33Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
33.33Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
33.33Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
33.33Consensusorexin_offOrthosteric Ligandox2_off ox1_off
33.33Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
33.33Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
33.33Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
33.33Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
33.33Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
33.33Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.14Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
32.14Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
32.14Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
32.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
32.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
32.00Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
31.82Single4N4WSANT-14N4W-SMO-SANT-1
31.82Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
31.82Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
31.82Single7DFPSpiperone7DFP-D2-Spiperone
31.82Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
31.82Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
31.82Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.82Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
31.82Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
31.82Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.82Single8XYIVUF106618XYI-CXCR3-VUF10661
31.82Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
31.82Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
31.82Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
31.82Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
31.82Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
31.82Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
31.82Consensuslpa_offOrthosteric Ligandlpa1_off
31.82Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
31.82Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.82Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.58Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
31.58Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
31.58Single3REYXAC3REY-A2A-XAC
31.58Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
31.58Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
31.58Single5IUBQ274563445IUB-A2A-Q27456344-Na
31.58Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
31.58Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
31.58Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
31.58Single6AQFZM-2413856AQF-A2A-ZM-241385
31.58Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
31.58Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
31.58Single6TP3Nemorexant6TP3-OX1-Nemorexant
31.58Single6V9SGTPL114036V9S-OX1-GTPL11403
31.58Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
31.58Single7AROLUF58337ARO-A2A-LUF5833-Na
31.58Single7T32ZM-2413857T32-A2A-ZM-241385
31.58Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
31.58Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
31.58Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
31.58Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
31.58Single8IHKAcifran8IHK-HCA3-Acifran
31.58Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
31.58Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
31.58Single8K5CAcipimox8K5C-HCA2-Acipimox
31.58Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
31.58Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
31.58Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
31.58Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
31.58Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
31.58Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
31.58Consensusopsins_offOrthosteric Ligandrhodopsin_off
31.58Consensussensory_offOrthosteric Ligandopsins_off
31.25Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
31.25Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
31.25Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
31.25Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
31.25Consensussensory_onOrthosteric Ligandopsins_on
31.03Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
31.03Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
31.03Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
31.03Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
31.03Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
30.77Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
30.77Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
30.43Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
30.43Single6K1QIRL25006K1Q-ETB-IRL2500
30.43Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
30.43Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.43Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
30.43Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
30.43Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.43Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
30.43Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
30.43Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
30.43Single8XVJMacitentan8XVJ-ETA-Macitentan
30.43Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
30.43Consensuscck_onOrthosteric Ligandccka_on cckb_on
30.43Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
30.43Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
30.43Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
30.00Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
30.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
30.00Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
30.00Single5UENDU1725UEN-A1-DU172
30.00Single6D27CAY104716D27-DP2-CAY10471
30.00Single6IGLIRL16206IGL-ETB-IRL1620
30.00Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
30.00Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
30.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
30.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
30.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
30.00Single7PYRPSB-21157PYR-A2A-PSB-2115
30.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
30.00Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
30.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
30.00Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
30.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
30.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
30.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
30.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
30.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
30.00Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
30.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
30.00Single8K5DGSK2560738K5D-HCA2-GSK256073
30.00Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
30.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
30.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
30.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
30.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
30.00Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
30.00Consensusblt_onOrthosteric Ligandblt1_on
30.00Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
30.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
30.00Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
30.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
30.00Consensusleukotriene_onOrthosteric Ligandblt_on
30.00Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
29.63Single6JODAngiotensin II6JOD-AT2-Angiotensin II
29.63Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
29.41Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
29.41Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
29.41Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
29.41Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
29.41Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
29.41Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
29.41Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
29.41Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
29.41Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
29.41Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
29.17Single5ZTYAM102575ZTY-CB2-AM10257
29.17Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
29.17Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
29.17Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
29.17Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
29.17Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
29.17Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
29.17Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
29.17Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
29.03Single6IGKEndothelin-36IGK-ETB-Endothelin-3
29.03Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
29.03Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
28.57Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
28.57Single5IUAQ274563485IUA-A2A-Q27456348-Na
28.57Single5N2RPSB-365N2R-A2A-PSB-36-Na
28.57Single5N2SPSB365N2S-A1-PSB36
28.57Single6GPXMK08126GPX-CCR2-MK0812
28.57Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
28.57Single6S0QZM-2413856S0Q-A2A-ZM-241385
28.57Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
28.57Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
28.57Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
28.57Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
28.57Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
28.57Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
28.57Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
28.57Single7SINNPS-21437SIN-CaS-NPS-2143
28.57Single7SINNPS-21437SIN-CaS-NPS-2143
28.57Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
28.57Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
28.57Single7W41PD1762527W41-BB2-PD176252
28.57Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
28.57Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
28.57Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
28.57Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
28.57Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
28.57Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
28.57Single8GNEKW-63568GNE-A2A-KW-6356-Na
28.57Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
28.57Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
28.57Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
28.57Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
28.57Single8S4DCMF-0198S4D-Apelin-CMF-019
28.57Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
28.57Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
28.57Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
28.57Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
28.57Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
28.57Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
28.57Single8ZRTET-18ZRT-ETB-ET-1
28.57Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
28.57Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
28.57Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
28.57Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
28.57Consensusbombesin_offOrthosteric Ligandbb2_off
28.57Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.57Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
28.57Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
28.57Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
28.57Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
28.57Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
28.57Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
28.57Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
28.12Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
28.12Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
28.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
28.00Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
28.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
28.00Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.00Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
28.00Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
28.00Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.00Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
28.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
28.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
28.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
27.78Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
27.78Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
27.78Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
27.78Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
27.78Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
27.78Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
27.78Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
27.78Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
27.78Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
27.78Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
27.78Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
27.78Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
27.78Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
27.78Single8K5BNiacin8K5B-HCA2-Niacin
27.78Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
27.78Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
27.78Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
27.78Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
27.78Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
27.59Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
27.59Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
27.59Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
27.59Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
27.27Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
27.27Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
27.27Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
27.27Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
27.27Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
27.27Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
27.27Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
27.27Single7PX4PSB-21137PX4-A2A-PSB-2113
27.27Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
27.27Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
27.27Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
27.27Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
27.27Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
27.27Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
27.27Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
27.27Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
27.27Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
27.27Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
27.27Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
27.27Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
27.27Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
27.27Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
27.27Consensuslpa_onOrthosteric Ligandlpa1_on
27.27Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
27.27Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
27.27Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
26.92Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
26.92Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
26.92Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
26.92Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
26.92Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
26.92Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
26.92Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
26.92Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
26.92Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
26.92Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
26.92Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
26.92Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
26.67Single5MZPCaffeine5MZP-A2A-Caffeine-Na
26.67Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
26.67Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
26.67Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
26.67Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
26.47Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
26.32Single3PWHZM-2413853PWH-A2A-ZM-241385
26.32Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
26.32Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
26.32Single4S0VSuvorexant4S0V-OX2-Suvorexant
26.32Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
26.32Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
26.32Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
26.32Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
26.32Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
26.32Single6TPJSuvorexant6TPJ-OX2-Suvorexant
26.32Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
26.32Single7F8ULintitript7F8U-CCKA-Lintitript
26.32Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
26.32Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
26.32Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
26.32Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
26.32Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
26.32Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
26.32Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
26.32Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
26.32Single8GNGIstradefylline8GNG-A2A-Istradefylline
26.32Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
26.32Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
26.32Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
26.32Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
26.32Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
26.32Single8Y0HVUF114188Y0H-CXCR3-VUF11418
26.32Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.32Consensusangiotensin_offOrthosteric Ligandat1_off
26.32Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.32Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
26.32Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
26.32Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.32Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.09Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
26.09Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
26.09Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
26.09Single7K15MKD0467K15-BLT1-MKD046-Na
26.09Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
26.09Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
26.09Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
26.09Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
26.09Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
26.09Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
26.09Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
26.09Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
26.09Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
26.09Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
26.09Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
26.09Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
26.09Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
26.09Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
26.09Consensuslpl_offOrthosteric Ligands1p_off lpa_off
26.09Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
26.09Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
26.09Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
26.09Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
25.93Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
25.93Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
25.93Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
25.93Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
25.93Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
25.93Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
25.81Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
25.81Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
25.81Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
25.00Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
25.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
25.00Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
25.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
25.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
25.00Single5JTBZM-2413855JTB-A2A-ZM-241385
25.00Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
25.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
25.00Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
25.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
25.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
25.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
25.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
25.00Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
25.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
25.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
25.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
25.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
25.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
25.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
25.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.00Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
25.00Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
25.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
25.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
25.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
25.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
25.00Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
25.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
25.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
25.00Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
25.00Single8PWNTheophylline8PWN-A2A-Theophylline
25.00Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
25.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
25.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
25.00Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
25.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
25.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
25.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
25.00Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
25.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
25.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusa2_offOrthosteric Liganda2a_off
25.00Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
25.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
25.00Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
25.00Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
25.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
25.00Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
25.00Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
25.00Consensuschemerin_onOrthosteric Ligandcml1_on
25.00Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
25.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
25.00Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
25.00Consensushca_onOrthosteric Ligandhca2_on
25.00Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
25.00Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
25.00Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
25.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
24.24Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
24.24Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
24.24Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
24.14Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
24.14Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.14Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
24.14Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
24.14Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
24.14Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
24.14Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
24.14Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
24.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
24.00Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
24.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
24.00Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single8QJ2pN1628QJ2-MC4-pN162-Gs
24.00Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
24.00Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
24.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
24.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
24.00Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
24.00Consensuskisspeptin_onOrthosteric Ligandkiss1_on
23.81Single3EMLZM-2413853EML-A2A-ZM-241385
23.81Single4YAYZD-71554YAY-AT1-ZD-7155
23.81Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
23.81Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
23.81Single5TGZAM65385TGZ-CB1-AM6538
23.81Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
23.81Single6GPSMK08126GPS-CCR2-MK0812
23.81Single6S0LZM-2413856S0L-A2A-ZM-241385
23.81Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
23.81Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
23.81Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
23.81Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
23.81Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
23.81Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
23.81Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
23.81Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
23.81Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
23.81Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
23.81Consensushca_on_gpOrthosteric Ligandhca2_on_gp
23.81Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
23.81Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
23.81Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
23.53Single3RFMCaffeine3RFM-A2A-Caffeine
23.53Single6TQ9SB-4081246TQ9-OX1-SB-408124
23.53Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
23.53Single8A2OTheophylline8A2O-A2A-Theophylline-Na
23.33Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
23.33Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
23.33Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
23.08Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
23.08Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
23.08Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
23.08Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
23.08Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
23.08Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.73Single5CGCHTL142425CGC-mGlu5-HTL14242
22.73Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
22.73Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
22.73Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
22.73Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
22.73Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
22.73Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
22.73Single7C4SS1P7C4S-S1P3-S1P
22.73Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
22.73Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
22.73Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
22.73Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
22.73Single8QOTNanobody-E8QOT-μ-Nanobody-E
22.73Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
22.73Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
22.73Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
22.73Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
22.73Consensusblt_offOrthosteric Ligandblt1_off
22.73Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
22.73Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
22.73Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
22.73Consensusep_offOrthosteric Ligandep4_off
22.73Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
22.73Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
22.73Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
22.73Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
22.73Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
22.73Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
22.58Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
22.58Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
22.58Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
22.58Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
22.58Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
22.22Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
22.22Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
22.22Single6ME5Agomelatine6ME5-MT1-Agomelatine
22.22Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
22.22Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
22.22Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
22.22Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
22.22Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
22.22Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
22.22Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
22.22Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
22.22Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
22.22Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
22.22Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
22.22Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
22.22Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
22.22Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
22.22Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
22.22Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
22.22Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
22.22Consensusgi_sensoryOrthosteric Ligandgi_opsins
22.22Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
22.22Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
22.22Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
21.88Single8IY6Endothelin-18IY6-ETB-Endothelin-1
21.88Consensusendothelin_onOrthosteric Ligandetb_on eta_on
21.88Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
21.74Single5XR8AM8415XR8-CB1-AM841
21.74Single5XRAAM115425XRA-CB1-AM11542
21.74Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
21.74Single7R0CAVP7R0C-V2-AVP-Arrestin2
21.74Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
21.74Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
21.74Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
21.74Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
21.74Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
21.74Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
21.74Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
21.74Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
21.74Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
21.74Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
21.74Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
21.74Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
21.74Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
21.74Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
21.74Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
21.74Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
21.74Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
21.74Consensusrelaxin_onOrthosteric Ligandrxfp4_on
21.74Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
21.62Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
21.62Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
21.43Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
21.43Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
21.43Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
21.43Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
21.43Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
21.43Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
21.43Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
21.43Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
21.43Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.43Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
21.43Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
21.05Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
21.05Single3OE9IT1t3OE9-CXCR4-IT1t
21.05Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
21.05Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
21.05Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
21.05Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
21.05Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
21.05Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
21.05Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
21.05Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
21.05Single9B9Y7DY9B9Y-CB1-7DY
21.05Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
21.05Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
20.83Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
20.83Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
20.83Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.83Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
20.83Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
20.83Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
20.83Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
20.83Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
20.83Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
20.83Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
20.83Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
20.69Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
20.69Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
20.69Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
20.69Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
20.69Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
20.69Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
20.69Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
20.69Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
20.69Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.69Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.69Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
20.69Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.69Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
20.69Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
20.69Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
20.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
20.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
20.00Single5CGDHTL142425CGD-mGlu5-HTL14242
20.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
20.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
20.00Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
20.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
20.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
20.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
20.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
20.00Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
20.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
20.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
20.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
20.00Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
20.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
20.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
20.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
20.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
20.00Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
20.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
20.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
20.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
20.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
20.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
20.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
20.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
20.00Single9BA0A1AKN9BA0-CB1-A1AKN
20.00Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
20.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
20.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
20.00Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
20.00Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
20.00Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
20.00Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
20.00Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.00Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
20.00Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
20.00Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
20.00Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single4XT3Fractalkine4XT3-US28-Fractalkine
19.35Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
19.35Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
19.35Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
19.35Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
19.35Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
19.23Single5EE7MK08935EE7-Glucagon-MK0893
19.23Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
19.23Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
19.23Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
19.23Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
19.23Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
19.23Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
19.05Single5UVIZM-2413855UVI-A2A-ZM-241385
19.05Single6MH8ZM-2413856MH8-A2A-ZM-241385
19.05Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
19.05Single6TPKRetosiban6TPK-OT-Retosiban
19.05Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
19.05Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
19.05Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8K2WAMG4878K2W-CXCR3-AMG487
19.05Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
19.05Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
19.05Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
19.05Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
19.05Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
19.05Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
19.05Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
19.05Consensusvasop-oxy_offOrthosteric Ligandot_off
18.75Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
18.75Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
18.75Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
18.75Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
18.75Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
18.75Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
18.60Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
18.52Single4XT1Fractalkine4XT1-US28-Fractalkine
18.52Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
18.52Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
18.52Single7QA8Peptide7QA8-STE2-Peptide
18.52Single7QA8Peptide7QA8-STE2-Peptide
18.52Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
18.52Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
18.52Single8IEBA1LYA8IEB-GPR156-A1LYA
18.52Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
18.52Single8WKYPG-9348WKY-MC4-PG-934
18.52Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
18.52Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
18.52Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
18.52Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
18.18Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
18.18Single6IIVDaltroban6IIV-TP-Daltroban
18.18Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
18.18Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
18.18Single7F83PF-051904577F83-Ghrelin-PF-05190457
18.18Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
18.18Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
18.18Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
18.18Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
18.18Single7V3ZCP559407V3Z-CB1-CP55940
18.18Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
18.18Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
18.18Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
18.18Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
18.18Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
18.18Single9B9ZA1AKO9B9Z-CB1-A1AKO
18.18Single9IYAONO-97105319IYA-GPR55-ONO-9710531
18.18Consensuscck_offOrthosteric Ligandccka_off
18.18Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
17.86Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
17.86Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
17.86Single7SK5CXCL127SK5-ACKR3-CXCL12
17.86Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
17.86Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
17.86Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
17.86Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
17.65Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
17.65Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
17.39Single4NTJAZD12834NTJ-P2Y12-AZD1283
17.39Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
17.39Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
17.39Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
17.39Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
17.39Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
17.39Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
17.39Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
17.39Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
17.39Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single3OE0CVX153OE0-CXCR4-CVX15
17.24Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
17.24Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
17.24Single6W25SHU91196W25-MC4-SHU9119-Ca
17.24Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
17.24Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.24Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
17.24Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
17.14Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
16.67Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
16.67Single3OE8IT1t3OE8-CXCR4-IT1t
16.67Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
16.67Single5V56TC1145V56-SMO-TC114
16.67Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
16.67Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
16.67Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
16.67Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
16.67Single7FEECP559407FEE-CB1-CP55940-ZCZ011
16.67Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
16.67Single7P2L4YI7P2L-mGlu5-4YI
16.67Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
16.67Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
16.67Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
16.67Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
16.67Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
16.67Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
16.67Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
16.67Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
16.67Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
16.67Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
16.67Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
16.67Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
16.67Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
16.67Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
16.67Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
16.13Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
16.13Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
16.13Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
16.13Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
16.13Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
16.13Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
16.13Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single5X33BIIL2605X33-BLT1-BIIL260
16.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
16.00Single6IIURamatroban6IIU-TP-Ramatroban
16.00Single6KQICP559406KQI-CB1-CP55940-Org27569
16.00Single6OS2TRV0266OS2-AT1-TRV026
16.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
16.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
16.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
16.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
16.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
16.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
16.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.00Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
16.00Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
15.79Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
15.79Single3OE6IT1t3OE6-CXCR4-IT1t
15.79Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
15.79Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
15.79Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
15.79Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
15.79Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
15.79Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
15.62Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
15.62Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
15.62Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
15.62Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
15.62Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
15.38Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
15.38Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
15.38Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
15.38Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
15.38Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
15.38Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
15.15Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
15.15Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
15.00Single5L7IVismodegib5L7I-SMO-Vismodegib
15.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
15.00Single6LI0C176LI0-GPR52-C17
15.00Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
15.00Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
15.00Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
15.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
15.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
14.81Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
14.81Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
14.81Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
14.81Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
14.81Single8IEIA1LYA8IEI-GPR156-A1LYA
14.81Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
14.81Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
14.81Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
14.81Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
14.81Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
14.81Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
14.71Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
14.71Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
14.71Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
14.71Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
14.29Single3ODUIT1t3ODU-CXCR4-IT1t
14.29Single5U09Taranabant5U09-CB1-Taranabant
14.29Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
14.29Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
14.29Single7BR3Elagolix7BR3-GnRH1-Elagolix
14.29Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
14.29Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
14.29Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
14.29Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.29Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.29Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
14.29Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
14.29Single8IEIA1LYA8IEI-GPR156-A1LYA
14.29Single8IEPA1LYA8IEP-GPR156-A1LYA
14.29Single8IEPA1LYA8IEP-GPR156-A1LYA
14.29Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
14.29Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
14.29Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
14.29Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
14.29Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
14.29Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
14.29Consensussomatostatin_offOrthosteric Ligandsst2_off
13.89Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
13.89Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
13.89Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
13.89Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
13.79Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
13.79Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
13.79Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
13.79Single7XNACYN1548067XNA-SST2-CYN154806
13.79Single8IEBA1LYA8IEB-GPR156-A1LYA
13.79Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
13.79Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
13.79Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
13.79Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
13.79Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
13.64Single6FFIMMPEP6FFI-mGlu5-MMPEP
13.64Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
13.64Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
13.64Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
13.64Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
13.64Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
13.64Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.64Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
13.64Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
13.64Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
13.64Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
13.64Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
13.64Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
13.64Consensusgrh_offOrthosteric Ligandgnrh1_off
13.64Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
13.51Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
13.51Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
13.33Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
13.33Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
13.33Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
13.16Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
13.16Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
13.04Single4QIMANTA XV4QIM-SMO-ANTA XV
13.04Single6FFHFenobam6FFH-mGlu5-Fenobam
13.04Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
13.04Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
13.04Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
13.04Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
13.04Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
13.04Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
13.04Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
13.04Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
13.04Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
13.04Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
13.04Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
12.90Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
12.90Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
12.90Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
12.90Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
12.90Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
12.90Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
12.90Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
12.90Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
12.82Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
12.50Single4JKVTaladegib4JKV-SMO-Taladegib
12.50Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
12.50Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
12.50Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
12.50Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
12.50Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
12.50Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
12.50Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
12.12Single6FJ3PTH6FJ3-PTH1-PTH
12.12Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
12.12Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
12.12Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
12.12Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
12.12Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
12.12Single7SK3CXCL127SK3-ACKR3-CXCL12
12.12Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
12.12Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
12.12Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
12.00Single5V57TC1145V57-SMO-TC114
12.00Single6OS1TRV0266OS1-AT1-TRV026
12.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
12.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
12.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
12.00Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
12.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
12.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
12.00Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
12.00Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.90Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
11.76Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
11.76Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
11.76Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
11.76Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
11.76Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
11.76Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
11.76Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
11.76Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
11.63Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
11.54Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
11.54Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
11.54Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
11.54Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
11.54Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
11.54Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
11.54Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
11.54Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
11.54Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
11.54Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
11.54Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
11.43Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
11.43Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
11.43Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
11.43Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
11.43Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
11.43Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
11.11Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
11.11Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
11.11Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
11.11Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
11.11Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
10.81Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
10.71Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
10.71Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
10.71Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
10.71Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
10.53Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
10.53Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
10.53Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
10.53Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.34Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
10.34Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
10.34Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.34Single8KIGSHU91198KIG-MC3-SHU9119-Ca
10.26Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
10.26Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
10.26Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
10.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
10.00Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
10.00Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
10.00Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
10.00Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
10.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
9.68Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
9.68Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
9.52Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
9.52Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
9.52Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
9.52Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
9.52Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
9.52Consensusgq_nucleotideOrthosteric Ligandgq_p2y
9.52Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.38Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
9.09Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
9.09Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
9.09Single5ZKQABT-4915ZKQ-PAF-ABT-491
9.09Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
9.09Single7F8YDevazepide7F8Y-CCKA-Devazepide
9.09Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
9.09Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
9.09Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
9.09Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
9.09Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
9.09Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
9.09Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.09Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
8.82Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
8.82Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
8.70Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
8.70Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
8.57Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
8.33Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
8.33Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
8.33Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
8.33Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
8.33Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
8.33Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
8.33Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.33Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
8.11Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
8.00Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
8.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
8.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
8.00Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
8.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.00Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.00Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
8.00Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
7.89Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
7.89Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
7.69Single5TZRMK86665TZR-FFA1-MK8666
7.69Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
7.69Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
7.69Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
7.69Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
7.69Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
7.50Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
7.41Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
7.41Single4PY02MeSATP4PY0-P2Y12-2MeSATP
7.41Single4XEENeurotensin4XEE-NTS1-Neurotensin
7.41Single4XESNeurotensin4XES-NTS1-Neurotensin
7.41Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.41Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
7.41Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.41Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
7.41Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
7.41Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
7.41Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
7.14Single4BUONeurotensin4BUO-NTS1-Neurotensin
7.14Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
7.14Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
6.90Single8XQJJN2418XQJ-Apelin-JN241
6.90Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
6.90Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
6.90Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
6.90Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
6.67Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
6.67Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
6.67Single8W8SAA-148W8S-GPR101-AA-14
6.67Single8XWNCXCL88XWN-CXCR2-CXCL8
6.67Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
6.67Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
6.45Single7SHEPI; PE7SHE-GPR158-PI; PE
6.45Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
6.25Single8W8RAA-148W8R-GPR101-AA-14-chim(NtGi1-Gs)/β1/γ2
6.25Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
6.06Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
5.88Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
5.88Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
5.56Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
5.56Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
5.56Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
5.26Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
5.26Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
5.26Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
5.26Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
5.26Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.00Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
5.00Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
4.88Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
4.76Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.76Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
4.76Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
4.76Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
4.76Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
4.76Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
4.55Single4O9RCyclopamine4O9R-SMO-Cyclopamine
4.55Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
4.55Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
4.55Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
4.35Single4QINSAG1.54QIN-SMO-SAG1.5
4.35Single4XNVBPTU4XNV-P2Y1-BPTU
4.35Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.35Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
4.35Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
4.35Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
4.35Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
4.35Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
4.35Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
4.35Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
4.17Single6ZINSR486926ZIN-NTS1-SR48692
4.17Single7VV6C48/807VV6-MRGPRX2-C48/80
4.17Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.17Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single8IYXYL-3658IYX-GPR34-YL-365
4.17Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.17Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
4.00Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
4.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
4.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
4.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
4.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
4.00Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
4.00Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
4.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
4.00Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
4.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
3.85Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
3.85Single6Z4SSR486926Z4S-NTS1-SR48692
3.85Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
3.85Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
3.70Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
3.70Single4BV0Neurotensin4BV0-NTS1-Neurotensin
3.70Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
3.70Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
3.70Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
3.70Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
3.70Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Consensusneurotensin_onOrthosteric Ligandnts1_on
3.70Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
3.57Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
3.57Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
3.57Single6YVRNTS8-136YVR-NTS1-NTS8-13
3.57Single7SHEPI; PE7SHE-GPR158-PI; PE
3.57Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.57Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
3.57Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
3.57Single8XQJJN2418XQJ-Apelin-JN241
3.57Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
3.57Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
3.57Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
3.57Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
3.45Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.45Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
3.45Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.45Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
3.45Single8XVUCXCL28XVU-CXCR2-CXCL2
3.45Single8XWFCXCL38XWF-CXCR2-CXCL3
3.45Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
3.33Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
3.33Single6KNMJN241-96KNM-Apelin-JN241-9
3.33Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
3.23Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
3.23Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.12Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
8DCR 8DCR-β1-Dobutamine-Gs/β1/γ2
7S0F 7S0F-β1-Isoprenaline-Gi1/β1/γ2
Net Summary
Imin 2.8
Number of Linked Nodes 874
Number of Links 1091
Number of Hubs 187
Number of Links mediated by Hubs 679
Number of Communities 29
Number of Nodes involved in Communities 262
Number of Links involved in Communities 383
Path Summary
Number Of Nodes in MetaPath 145
Number Of Links MetaPath 144
Number of Shortest Paths 1350034
Length Of Smallest Path 3
Average Path Length 28.5067
Length of Longest Path 61
Minimum Path Strength 0.7175
Average Path Strength 5.95689
Maximum Path Strength 25.43
Minimum Path Correlation 0.7
Average Path Correlation 0.977111
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.96078
Average % Of Corr. Nodes 43.0464
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 54.1409
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
beta1_off_on_gpbeta1_on_gpbeta1_off
This network is also present in following consensuses:
IdComponents
beta_on_gpbeta1_on_gp
beta2_on_gp
beta3_on_gp



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download beta1_on_gp.zip



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