Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.33 1.99963504
2G.S1.02 5.40526445
3G.S1.06 4.6358448
4G.H1.01 3.75687549
5G.S2.03 5.02668419
6G.S2.04 1.62478406
7G.S2.08 8.18563445
8G.S3.01 4.43048444
9G.S3.03 7.38187547
10G.S3.04 6.97717416
11G.S3.05 3.56174447
12G.S3.06 7.67635515
13G.s3h2.03 4.09007519
14G.H2.02 4.1911418
15G.H2.03 4.65694419
16G.H2.04 3.70734509
17G.H2.06 5.35762719
18G.H2.07 4.83852719
19G.h2s4.01 6.26626519
20G.h2s4.02 4.22368407
21G.S4.03 3.35268447
22G.S4.04 5.96223469
23G.s4h3.04 5.72496108
24G.s4h3.05 6.21834109
25G.H3.01 4.73214159
26G.H3.09 5.16253769
27G.H3.13 2.96643665
28G.H3.17 6.92878615
29G.H3.18 5.97794149
30G.S5.02 3.43068466
31G.S5.03 3.11797448
32G.S5.04 3.96833569
33G.S5.05 3.6882749
34G.S5.07 4.22792409
35G.HG.04 5.42228509
36G.HG.07 5.174044109
37G.HG.13 3.233544107
38G.hgh4.02 5.960326167
39G.hgh4.05 8.20966407
40G.H4.03 5.86737404
41G.H4.08 0.123574403
42G.H4.10 9.586644166
43G.H4.12 5.93777465
44G.H4.15 4.87404468
45G.h4s6.02 5.00984468
46G.S6.01 3.62647465
47G.S6.02 5.813425177
48G.H5.03 5.30753448
49G.H5.08 6.03991448
50G.H5.13 3.90918408
51G.H5.26 3.79407505
52b.1x2 1.24456401
53b.1x4 1.24073408
54b.h2x1 3.9752405
55b.h2x5 3.72233405
56b.lhb1x3 2.09477602
57b.lhb1x11 3.06013574
58b.b1x3 4.0515437
59b.b1x4 3.35702437
60b.b1x6 7.99888439
61b.l1x3 8.14349639
62b.b2x1 7.94859518
63b.b2x3 4.10344436
64b.b2x5 6.66216637
65b.b3x3 3.46528408
66b.l3x2 4.57733539
67b.b4x3 4.43545487
68b.b4x4 8.44872438
69b.b4x5 4.001994137
70b.b4x6 8.79301739
71b.b5x2 5.53519407
72b.b5x3 6.44501639
73b.b5x5 5.182064135
74b.b5x7 6.11986407
75b.l5x1 4.04747588
76b.l5x2 2.45173486
77b.l5x5 7.37996719
78b.b6x5 3.92326506
79b.l6x5 5.772724114
80b.b7x1 5.566195114
81b.b7x4 3.55744488
82b.l7x2 4.20531419
83b.l7x4 2.82724409
84b.b8x3 3.65184116
85b.b8x4 5.39983586
86b.l8x3 3.18974203
87b.l8x5 2.943245203
88b.b9x3 3.20242586
89b.l9x3 6.07951619
90b.l9x6 4.8194818
91b.b10x5 4.52332609
92b.b11x4 5.09869419
93b.l11x2 7.31679419
94b.b12x6 7.85389718
95b.b12x7 5.14547459
96b.b13x7 7.63993557
97b.l13x3 7.29263659
98b.l13x6 5.05922519
99b.l13x7 4.30054459
100b.b14x3 4.55636455
101b.b15x1 6.4712559
102b.b15x2 6.45809416
103b.b15x3 4.18796459
104b.l15x1 4.58531517
105b.l15x2 4.8581559
106b.b16x4 8.623556
107b.b16x5 4.60267405
108b.b16x6 8.39639658
109b.b17x7 8.09523418
110b.l17x3 7.85716719
111b.l17x6 6.48388419
112b.b18x3 4.88473418
113b.l18x1 5.33667896
114b.l18x2 5.52974497
115b.l18x3 6.70016495
116b.b19x2 6.53899616
117b.b19x4 6.30624418
118b.l19x2 6.03907519
119b.b20x4 10.1827518
120b.b20x6 6.97999616
121b.b20x7 4.01934409
122b.l20x2 5.68508409
123b.b21x1 6.94882517
124b.b21x4 3.75094405
125b.b21x5 5.0711404
126b.b21x7 5.45724605
127b.l21x2 5.12697404
128b.b22x5 5.55844597
129b.l22x5 5.608496199
130b.b23x6 6.27076717
131b.l23x1 7.69226416
132b.b24x4 7.07834416
133b.b24x6 6.26008418
134b.l24x2 4.43625406
135b.l24x3 4.66721405
136b.b25x3 6.39344415
137b.l25x3 8.16477579
138b.l25x6 11.5591418
139b.b26x3 3.79386406
140b.l27x1 10.4959719
141b.l27x2 7.26556479
142b.b28x3 3.97079537
143b.b28x4 7.24504476
144b.b28x6 7.64197679
145g.h1x1 0.760251502
146g.l1x4 4.04973408
147g.h2x11 8.77324496
148g.ctx3 6.03213509
149g.ctx6 3.27574406
150g.ctx13 3.04473435
151g.ctx14 5.29101439
152g.ctx15 6.2389439
153g.ctx16 4.12525938
154NT 1.59398423
1551x43 2.99974525
1561x50 5.53346409
1571x60 2.34267406
1582x40 2.74885409
1592x42 4.12793508
1602x46 4.35649429
1612x50 5.64427529
1622x57 5.21813427
163E1x50 6.62711628
164E1x52 5.42825506
1653x33 3.99009426
1663x37 3.37488627
1673x43 3.78889428
1683x50 5.39509529
1693x51 6.05631408
1704x46 3.3495407
171E2 11.71651723
1725x39 3.5792428
1735x44 3.9079427
1745x47 5.68641428
1755x51 2.83936406
1765x58 5.29105629
177I3 1.965965175
1786x30 2.26084508
1796x40 3.41511409
1806x44 4.0684529
1816x48 5.50531628
1826x49 4.00151406
1836x51 4.55692427
1846x52 5.52895427
185E3 3.645731323
1867x38 4.47944426
1877x42 5.26898427
1887x49 4.86599429
1897x53 4.53588529
1908x50 3.9327509
1918x53 1.34566408
192Lig 9.136362420
193H.HA.14 0.207019400
194H.HA.19 0.1955774210
195H.HA.20 0.179135400
196H.HA.26 0.186442400
197H.hbhc.13 0.178269400
198H.HC.03 0.199077500
199H.HC.11 0.387769500
200H.HD.07 0.20125400
201H.hdhe.01 0.237019400
202H.HE.05 0.278846400
203H.HF.03 0.357981400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.l2x3 b.l2x5 28.82423.15356NoNo085
2b.b3x1 b.l2x3 28.49035.32851NoNo058
3b.b3x1 b.b6x5 28.15623.73544NoYes056
4b.b3x3 b.b6x5 26.47793.63745YesYes086
5b.b3x2 b.b4x6 16.7224.66445NoYes359
6b.b2x3 b.b3x2 16.8414.32001YesNo365
7b.b26x2 b.b2x3 55.42555.09814NoYes076
8b.b26x1 b.b26x2 55.73552.94856NoNo097
9b.b26x1 b.l27x1 56.04765.33263NoYes099
10b.b2x1 b.l27x1 40.52338.21998YesYes189
11b.b2x1 b.l3x1 41.185512.9087YesNo189
12b.l3x1 b.l5x5 41.46857.09589NoYes199
13G.H3.17 b.l27x1 28.58173.46361YesYes159
14G.H3.15 G.H3.17 62.67924.84529NoYes085
15G.H3.15 G.H3.18 62.84034.53276NoYes089
16G.H2.08 G.H3.18 33.69724.85905NoYes089
17G.H2.04 G.H2.08 33.77892.77338YesNo098
18G.H2.04 G.H3.08 57.33083.51077YesNo099
19G.H3.08 G.S4.04 57.36685.46874NoYes099
20G.S4.04 G.S5.04 95.59432.80937YesYes699
21G.S5.04 G.S5.06 92.52843.35116YesNo098
22G.S5.06 G.s4h3.01 93.00167.78225NoNo087
23G.HG.04 G.s4h3.01 92.962610.1335YesNo097
24G.HG.04 G.s4h3.04 92.69035.11751YesYes098
25G.HG.07 G.s4h3.04 99.49836.86372YesYes1098
26G.HG.07 G.s4h3.02 99.96324.21728YesNo1099
27G.s4h3.02 G.s5hg.01 1005.14502NoNo099
28G.S5.07 G.s5hg.01 99.70662.20921YesNo099
29G.H1.04 G.S5.07 49.53144.69675NoYes079
30G.H1.04 G.S5.05 49.39553.64683NoYes079
31G.H3.18 G.S4.02 29.3058.24837YesNo1498
32G.S1.05 G.S4.02 29.49313.50839NoNo098
33G.S1.05 G.S1.07 45.8925.22351NoNo099
34G.S1.07 G.S4.04 45.98712.82218NoYes099
35G.h2s4.01 b.l5x5 24.151310.2542YesYes199
36G.S1.05 G.h2s4.01 16.493410.7446NoYes099
37G.S5.07 G.s6h5.01 50.04056.90547YesNo099
38G.S5.05 G.s6h5.01 49.36144.52038YesNo499
39b.l5x5 b.l7x2 17.98385.56068YesYes199
40G.H2.07 b.l9x6 49.09543.48986YesYes198
41G.H2.06 b.l9x6 24.71713.47688YesYes198
42G.H2.06 b.l17x6 23.64328.77966YesYes199
43G.S5.03 G.S5.05 90.93153.50566YesYes489
44G.H3.06 G.hgh4.02 13.13495.43925NoYes067
45b.l25x6 b.l27x1 13.356819.7316YesYes189
46G.H5.10 G.S5.03 91.68173.3993NoYes068
47G.H5.10 G.S6.02 91.50554.81606NoYes067
48G.H5.13 G.S6.02 89.25937.16505YesYes087
495x68 G.H5.13 88.67282.91912NoYes078
505x64 5x68 88.13624.21973NoNo067
513x55 5x64 87.95713.95758NoNo076
523x51 3x55 87.77788.09641YesNo087
533x51 5x57 85.6166.11124YesNo086
543x47 5x57 84.7462.51562NoNo096
553x47 5x58 17.3046.5625NoYes299
563x50 5x58 14.22156.87975YesYes299
577x54 8x50 13.5136.67453NoYes089
581x53 7x54 13.97583.47628NoNo098
591x53 2x47 14.43843.198NoNo099
601x50 2x47 14.90092.62497YesNo099
611x50 2x50 18.13478.2365YesYes099
622x46 2x50 12.36173.96444YesYes299
632x46 3x43 13.82223.61662YesYes298
643x43 6x44 26.44923.01033YesYes289
655x54 6x44 67.69143.33447NoYes289
663x47 5x54 67.26025.30163NoNo298
672x50 7x49 12.61425.33432YesYes299
683x43 7x49 12.41783.53119YesYes289
69b.l17x5 b.l17x6 24.98513.05697NoYes169
70b.l17x5 b.l19x2 24.8064.56918NoYes169
71b.l17x3 b.l19x2 23.18873.73012YesYes199
72b.b20x6 b.l17x3 18.10493.05294YesYes169
73b.b17x7 b.b20x6 12.21189.97738YesYes186
74b.l2x5 b.l4x2 29.469122.0516NoNo054
75b.l4x2 g.ctx16 28.25795.95847NoYes348
76b.l11x1 b.l9x6 35.39325.65664NoYes198
77b.b11x6 b.l11x1 36.98313.20383NoNo199
78b.b11x6 b.l9x3 35.319513.0175NoYes199
79b.b11x4 b.l9x3 12.37365.33122YesYes199
80b.b10x3 b.b11x4 12.72672.97826NoYes089
81b.b10x3 b.b6x2 12.54074.84551NoNo088
82b.b10x2 b.b6x2 12.34192.83476NoNo068
83b.b2x5 b.l4x1 34.22655.54729YesNo075
84b.l4x1 g.ctx16 33.91944.31226NoYes058
85b.b3x3 b.b4x3 23.10113.37113YesYes087
86b.b8x4 b.l8x10 12.08435.85343YesNo864
87b.b12x6 b.l9x3 21.90295.86667YesYes189
88b.b11x2 b.b12x6 21.52592.75455NoYes078
89b.b10x5 b.b11x2 21.33558.34937YesNo097
90b.b10x5 b.b8x3 19.99893.76987YesYes096
91b.b8x3 b.l12x1 16.60664.44247YesNo066
92b.b10x2 b.b14x3 10.52914.83079NoYes065
93b.l23x1 b.l25x6 28.995819.1025YesYes168
94b.l21x7 b.l23x1 28.63854.81396NoYes156
95b.b23x6 b.l21x7 27.27013.40255YesNo175
96b.b23x6 b.b24x6 23.76377.21185YesYes178
97b.b21x7 b.b24x6 23.33818.29352YesYes058
98b.b21x7 b.b23x2 10.17134.52197YesNo056
99b.b22x1 b.l25x6 17.17723.61626NoYes188
100b.b22x1 b.b22x2 17.08292.96674NoNo088
101b.b22x2 b.b26x3 16.8274.84267NoYes086
1023x36 Lig 33.02124.31833NoYes270
1033x36 6x48 33.19644.77418NoYes278
1046x44 6x48 37.19777.41753YesYes298
105b.b9x2 b.l12x1 16.41271.76806NoNo056
106H.HA.14 b.b9x2 16.04340.231923YesNo005
107b.b2x3 b.b2x5 37.95624.23819YesYes367
108b.b21x5 b.b21x7 11.91598.79578YesYes045
109b.b26x3 b.b27x3 10.72433.68506YesNo068
110G.H2.04 G.H2.07 32.32095.53554YesYes099
111G.H3.17 b.l25x6 33.043.78587YesYes158
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x324.791510NoNo7721
2x607x384.94862NoYes7611
2x607x423.490992NoYes7712
2x60Lig5.838532NoYes7010
2x63E1x505.869672NoYes5812
2x63Lig5.324342NoYes5010
E1x49E26.588022NoYes4321
3x25E1x506.977892NoYes9822
E1x50E23.687052YesYes8321
3x22E25.725692NoYes4321
3x283x293.299730NoNo6621
3x294x657.135272NoNo6612
3x29Lig4.351992NoYes6010
3x32Lig6.461162NoYes7010
3x334x573.035822YesNo6812
3x334x614.641192YesNo6712
3x33Lig5.041512YesYes6010
3x366x484.774182NoYes7812
3x36Lig4.318332NoYes7010
4x64E211.97682NoYes5321
4x65E2x525.38110NoNo6521
E2E254.25522YesYes3311
E2E2x5110.91072YesNo3411
E2Lig19.06342YesYes3010
E2x51Lig5.02112NoYes4010
E2E2x524.840532YesNo3511
E2x52Lig3.318992NoYes5010
5x35E27.580532NoYes4321
5x39E23.095322YesYes8321
5x325x352.936892NoNo5422
5x395x432.800382YesNo8721
6x486x523.40182YesYes8722
6x516x523.151862YesYes7712
6x516x555.787152YesNo7711
6x517x372.832332YesNo7612
6x51Lig6.456342YesYes7010
6x547x345.214910NoNo5521
6x547x373.312750NoNo5622
6x55Lig8.411392NoYes7010
6x58Lig8.112750NoYes4010
6x61E33.993120NoYes4321
E3E39.294212YesYes3311
E3Lig10.84372YesYes3010
7x347x384.179682NoYes5611
7x34Lig10.10212NoYes5010
7x387x424.521432YesYes6712
7x31Lig4.185422NoYes3010
7x38Lig4.268042YesYes6010
5x43Lig4.801392NoYes7010
2x647x354.665712NoNo6512
3x25E23.430152NoYes9321
4x615x393.520430NoYes7822
5x36E28.63422NoYes5321
LigNT2.834982YesYes0301
E1Lig4.266670NoYes0010
3x333x373.241842YesYes6712
3x375x433.315112YesNo7721
5x32E22.947552NoYes5321
7x26E33.016822NoYes0321
7x30E33.669410NoYes0321
7x27E32.697910NoYes0321
6x57E32.652450NoYes5321
2x64Lig2.63662NoYes6010
7x32NT2.424790NoYes3321
2x677x311.726920NoNo4321
5x31E21.342920NoYes0321
7x24NT1.040772NoYes0321
6x62Lig0.9397690NoYes0010
7x23E30.8157690NoYes0321
1x25Lig0.6857690NoYes0010
5x29E30.5034070NoYes0321
5x28E20.4982422NoYes0321
6x63E30.3843080NoYes0321
1x277x310.3842310NoNo0321
5x27E20.3484622NoYes0321
6x65E30.1684620NoYes0321
1x23NT0.07538462NoYes0321
1x237x240.07538462NoNo0022
1x22E30.06076920NoYes0321

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
87.50Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
87.50Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
82.61Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
82.61Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
80.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
78.26Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
69.57Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
67.86Single5GLHEndothelin-15GLH-ETB-Endothelin-1
67.86Single6IGKEndothelin-36IGK-ETB-Endothelin-3
66.67Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
64.29Single6IGLIRL16206IGL-ETB-IRL1620
64.00Consensusangiotensin_onOrthosteric Ligandat1_on
64.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
63.33Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
62.96Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
61.54Single6JODAngiotensin II6JOD-AT2-Angiotensin II
61.54Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
61.54Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
61.54Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
61.54Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
61.54Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
60.87Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
60.87Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
60.71Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
60.00Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
60.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
60.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
60.00Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
60.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
59.26Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
59.26Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
59.26Single8ZRTET-18ZRT-ETB-ET-1
59.26Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
58.62Single8IY6Endothelin-18IY6-ETB-Endothelin-1
58.62Consensusendothelin_onOrthosteric Ligandetb_on eta_on
57.69Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
57.69Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
57.14Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
57.14Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
57.14Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
56.67Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
56.52Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
56.52Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
56.52Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
56.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
56.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
55.56Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
55.56Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
55.17Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
55.17Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
55.17Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
55.17Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
54.84Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
54.84Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
54.55Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
53.85Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
53.85Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
53.85Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
53.85Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
53.85Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
53.85Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
53.57Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
53.57Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
53.57Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
53.57Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
53.57Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
53.33Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
53.33Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
53.33Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
53.33Consensusbradykinin_onOrthosteric Ligandbk2_on
53.33Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
53.33Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
53.33Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
52.17Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
52.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
52.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
52.00Single8QJ2pN1628QJ2-MC4-pN162-Gs
52.00Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
52.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
52.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
52.00Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
52.00Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
51.85Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
51.85Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
51.85Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
51.85Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
51.85Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
51.72Single4XT3Fractalkine4XT3-US28-Fractalkine
51.72Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
51.72Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
51.72Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
51.61Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
51.61Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
51.61Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
51.61Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
50.00Single4XT1Fractalkine4XT1-US28-Fractalkine
50.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
50.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
50.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
50.00Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
50.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
50.00Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
50.00Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
50.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
50.00Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
50.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
50.00Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
50.00Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
50.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
50.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
50.00Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
50.00Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
50.00Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
50.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
50.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
50.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
50.00Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
50.00Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
50.00Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
50.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
50.00Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
50.00Consensusorexin_onOrthosteric Ligandox2_on
50.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
50.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
50.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
48.48Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
48.39Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
48.28Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
48.28Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
48.28Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
48.28Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
48.28Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
48.28Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
48.28Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
48.28Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
48.28Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
48.28Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
48.28Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
48.28Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
48.28Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
48.15Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
48.15Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
48.15Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
48.15Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
48.15Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
48.15Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
48.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
48.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
48.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
48.00Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
48.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
48.00Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
48.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
48.00Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
47.83Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
47.83Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
46.88Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
46.88Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
46.88Consensusbombesin_onOrthosteric Ligandbb2_on
46.88Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
46.88Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
46.67Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
46.67Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
46.67Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
46.67Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
46.67Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
46.43Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
46.43Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
46.43Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
46.43Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
46.43Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
46.43Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
46.15Single4UG2CGS216804UG2-A2A-CGS21680
46.15Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
46.15Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
46.15Single7XN9L-054,5227XN9-SST2-L-054,522
46.15Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
46.15Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
46.15Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
46.15Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
46.15Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
46.15Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
46.15Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
46.15Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
46.15Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
46.15Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
45.83Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
45.83Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
45.83Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
45.83Single8E0GBU728E0G-μ-BU72
45.83Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
45.83Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
45.83Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
45.83Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
45.83Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
45.83Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
45.45Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
45.45Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
45.45Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
45.45Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
45.45Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
45.45Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
45.45Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
45.16Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
44.83Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
44.83Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
44.83Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
44.83Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
44.44Single4IARErgotamine4IAR-5-HT1B-Ergotamine
44.44Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
44.44Single7F8XNN90567F8X-CCKA-NN9056
44.44Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
44.44Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
44.44Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
44.44Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
44.44Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
44.44Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
44.44Single8WDTphotoNECA8WDT-A2A-photoNECA
44.44Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
44.44Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
44.44Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
44.44Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
44.44Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
44.44Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
44.44Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
44.44Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
44.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
44.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
44.00Single4XESNeurotensin4XES-NTS1-Neurotensin
44.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
44.00Single6MXTSalmeterol6MXT-β2-Salmeterol
44.00Single6OS2TRV0266OS2-AT1-TRV026
44.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
44.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
44.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
44.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
44.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
44.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
44.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
44.00Single8JJLOlodaterol8JJL-β2-Olodaterol
44.00Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
44.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
44.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
44.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
44.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
44.00Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
44.00Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
44.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
44.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
44.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
44.00Consensuslpa_offOrthosteric Ligandlpa1_off
44.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
44.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
44.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
44.00Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
44.00Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
44.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
44.00Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
43.75Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
43.48Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
43.48Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
43.48Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
43.48Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
43.48Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
43.48Single8K5DGSK2560738K5D-HCA2-GSK256073
43.48Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
43.48Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
43.48Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
43.48Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
43.48Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
43.48Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
43.48Consensushca_on_gpOrthosteric Ligandhca2_on_gp
43.48Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
43.33Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
43.33Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
43.33Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
43.33Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
43.33Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
43.33Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
42.86Single3QAKUK-4320973QAK-A2A-UK-432097
42.86Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
42.86Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
42.86Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
42.86Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
42.86Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
42.86Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
42.86Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
42.86Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
42.86Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
42.42Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
42.31Single4BUONeurotensin4BUO-NTS1-Neurotensin
42.31Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
42.31Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
42.31Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
42.31Single7EZCUKA7EZC-A2A-UKA
42.31Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
42.31Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
42.31Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
42.31Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
42.31Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
42.31Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
42.31Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
42.31Consensuschemerin_onOrthosteric Ligandcml1_on
42.31Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.31Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.31Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
42.31Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
42.31Consensusprostanoid_offOrthosteric Ligandep_off dp_off
41.94Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
41.94Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
41.94Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
41.94Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
41.94Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
41.67Single5C1MBU725C1M-μ-BU72
41.67Single5N2SPSB365N2S-A1-PSB36
41.67Single6D26Fevipiprant6D26-DP2-Fevipiprant
41.67Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
41.67Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
41.67Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.67Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
41.67Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
41.67Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
41.67Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
41.67Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
41.67Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
41.67Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
41.67Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
41.67Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
41.67Consensusdp_offOrthosteric Liganddp2_off
41.38Single3OE0CVX153OE0-CXCR4-CVX15
41.38Single5WF5UK-4320975WF5-A2A-UK-432097
41.38Single6PT2KGCHM076PT2-δ-KGCHM07
41.38Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
41.38Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
41.38Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
41.38Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
41.38Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
41.38Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
41.38Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
41.38Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
41.38Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
40.91Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
40.91Single8GNGIstradefylline8GNG-A2A-Istradefylline
40.91Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
40.74Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
40.74Single5WF6UK-4320975WF6-A2A-UK-432097
40.74Single5ZTYAM102575ZTY-CB2-AM10257
40.74Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
40.74Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
40.74Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
40.74Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
40.74Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
40.74Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
40.74Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
40.74Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
40.74Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
40.74Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
40.74Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
40.74Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
40.74Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
40.74Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
40.62Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
40.62Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
40.62Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
40.62Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
40.00Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
40.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
40.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
40.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
40.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
40.00Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
40.00Single6OS1TRV0266OS1-AT1-TRV026
40.00Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
40.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
40.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
40.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
40.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
40.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
40.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
40.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
40.00Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
40.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
40.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
40.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
40.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
40.00Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
40.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
40.00Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
40.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
40.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
40.00Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
40.00Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
40.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
40.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
40.00Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
40.00Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
40.00Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
40.00Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
40.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
40.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
40.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
40.00Consensusneurotensin_onOrthosteric Ligandnts1_on
40.00Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
40.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
40.00Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
40.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
40.00Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
40.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
40.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
40.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
40.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
39.39Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
39.39Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
39.29Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
39.29Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
39.29Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
39.29Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
39.29Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
39.29Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
39.29Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
39.29Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
39.29Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
39.29Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
39.29Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
39.29Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
39.29Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
39.29Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
39.13Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
39.13Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
39.13Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
39.13Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
39.13Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
39.13Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
39.13Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
39.13Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
39.13Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
39.13Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
39.13Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
39.13Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
39.13Consensushca_onOrthosteric Ligandhca2_on
38.71Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
38.71Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
38.71Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
38.71Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
38.71Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
38.71Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
38.46Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
38.46Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
38.46Single6YVRNTS8-136YVR-NTS1-NTS8-13
38.46Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
38.46Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
38.46Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
38.46Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
38.46Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
38.46Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
38.46Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
38.46Single7YITNalfurafine7YIT-κ-Nalfurafine
38.46Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
38.46Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
38.46Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
38.46Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
38.46Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.46Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
38.46Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
38.46Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
38.46Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
38.46Consensusalpha1_offOrthosteric Ligandalpha1a_off
38.46Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
38.46Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
38.46Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
38.46Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
38.46Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
38.46Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
38.46Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
38.46Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
38.46Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
38.46Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
38.24Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
38.10Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
37.93Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
37.93Single7SK5CXCL127SK5-ACKR3-CXCL12
37.93Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
37.93Single7XNACYN1548067XNA-SST2-CYN154806
37.93Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
37.93Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
37.93Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
37.93Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
37.50Single6D27CAY104716D27-DP2-CAY10471
37.50Single6TOTLemborexant6TOT-OX1-Lemborexant
37.50Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
37.50Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
37.50Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
37.50Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
37.50Single7SK3CXCL127SK3-ACKR3-CXCL12
37.50Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
37.50Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
37.50Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
37.50Single7UL4Alvimopan7UL4-μ-Alvimopan
37.50Single7V3ZCP559407V3Z-CB1-CP55940
37.50Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
37.50Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
37.50Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
37.50Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
37.50Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
37.50Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
37.50Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
37.50Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
37.50Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
37.50Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
37.50Single9CHXS-Carazolol9CHX-β2-S-Carazolol
37.50Consensusa3_onOrthosteric Liganda3a_on
37.50Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
37.50Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
37.50Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
37.50Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
37.04Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
37.04Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
37.04Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
37.04Single6IBLArformoterol6IBL-β1-Arformoterol
37.04Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
37.04Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
37.04Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
37.04Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
37.04Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
37.04Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
37.04Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.04Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
37.04Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
37.04Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
37.04Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
37.04Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
37.04Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
37.04Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
37.04Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
37.04Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
37.04Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
37.04Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
37.04Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.04Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
37.04Consensusendothelin_offOrthosteric Ligandetb_off
37.04Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
37.04Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
37.04Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
37.04Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
36.67Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
36.67Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
36.67Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
36.67Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
36.67Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
36.67Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
36.67Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
36.67Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
36.67Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
36.67Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
36.67Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
36.67Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Single3OE9IT1t3OE9-CXCR4-IT1t
36.36Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
36.36Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
36.36Consensusgq_nucleotideOrthosteric Ligandgq_p2y
36.36Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
36.00Single5N2RPSB-365N2R-A2A-PSB-36-Na
36.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
36.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
36.00Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
36.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
36.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
36.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
36.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
36.00Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
36.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
36.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
36.00Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
36.00Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
36.00Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
36.00Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
36.00Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
36.00Single8JXSPF-61428JXS-D1-PF-6142
36.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
36.00Single8S4DCMF-0198S4D-Apelin-CMF-019
36.00Single8TF5Oleic acid8TF5-GPR6-Oleic acid
36.00Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.00Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.00Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
36.00Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
36.00Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
36.00Consensusa3_on_gpOrthosteric Liganda3a_on_gp
36.00Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
36.00Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
36.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
36.00Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
36.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
36.00Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
36.00Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
36.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
36.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
36.00Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
36.00Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
36.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
36.00Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
35.90Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
35.71Single3NY9ICI118-5513NY9-β2-ICI118-551
35.71Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
35.71Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
35.71Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
35.71Single8XQJJN2418XQJ-Apelin-JN241
35.71Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
35.71Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
35.71Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
35.48Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
35.48Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
35.48Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
35.48Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
35.48Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
35.48Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
35.48Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
35.48Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
35.48Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
35.29Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
35.29Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
34.78Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
34.78Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
34.78Single6AKXA4R6AKX-CCR5-A4R
34.78Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
34.78Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
34.78Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
34.78Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
34.78Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
34.78Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
34.78Single7XRRLemborexant7XRR-OX2-Lemborexant
34.78Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
34.78Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
34.78Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
34.78Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
34.78Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
34.78Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
34.78Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
34.78Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
34.78Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
34.78Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
34.78Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
34.78Consensusorexin_offOrthosteric Ligandox2_off ox1_off
34.78Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
34.62Single2YDVNECA2YDV-A2A-NECA
34.62Single3P0GBI1671073P0G-β2-BI167107
34.62Single4BV0Neurotensin4BV0-NTS1-Neurotensin
34.62Single4UHRCGS216804UHR-A2A-CGS21680
34.62Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
34.62Single5G53NECA5G53-A2A-NECA-Gs
34.62Single5XR8AM8415XR8-CB1-AM841
34.62Single5XRAAM115425XRA-CB1-AM11542
34.62Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
34.62Single6H7JIsoprenaline6H7J-β1-Isoprenaline
34.62Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
34.62Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
34.62Single6WGTLSD6WGT-5-HT2A-LSD
34.62Single7B6WCyclazosin7B6W-α1b-Cyclazosin
34.62Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
34.62Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
34.62Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
34.62Single7FEECP559407FEE-CB1-CP55940-ZCZ011
34.62Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
34.62Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
34.62Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
34.62Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
34.62Single7TUYGSK682753A7TUY-GPR183-GSK682753A
34.62Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
34.62Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.62Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
34.62Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
34.62Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
34.62Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
34.62Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.62Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
34.62Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
34.62Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.62Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
34.62Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
34.62Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
34.62Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
34.62Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
34.62Consensusa2_onOrthosteric Liganda2b_on
34.62Consensusa2_on_gpOrthosteric Liganda2b_on_gp
34.62Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
34.62Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
34.62Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
34.62Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
34.62Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.62Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
34.62Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
34.62Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
34.62Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
34.62Consensuslpa_onOrthosteric Ligandlpa1_on
34.62Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
34.48Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
34.48Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
34.48Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
34.48Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
34.48Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
34.48Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
34.48Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
34.48Single8WKYPG-9348WKY-MC4-PG-934
34.48Single8XWNCXCL88XWN-CXCR2-CXCL8
34.48Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
34.48Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
34.48Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
34.48Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
34.48Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
34.48Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
34.48Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Consensussomatostatin_offOrthosteric Ligandsst2_off
34.38Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
34.38Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
34.38Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
34.38Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
34.38Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
34.29Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
33.33Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
33.33Single4AMIBucindolol4AMI-β1-Bucindolol
33.33Single4LDEBI1671074LDE-β2-BI167107
33.33Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
33.33Single4MBSMaraviroc4MBS-CCR5-Maraviroc
33.33Single4ZJCSB-6740424ZJC-OX1-SB-674042
33.33Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
33.33Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
33.33Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
33.33Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
33.33Single6FJ3PTH6FJ3-PTH1-PTH
33.33Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
33.33Single6KQICP559406KQI-CB1-CP55940-Org27569
33.33Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
33.33Single6MH8ZM-2413856MH8-A2A-ZM-241385
33.33Single6PS0S-Carazolol6PS0-β2-S-Carazolol
33.33Single6PS4ICI118-5516PS4-β2-ICI118-551
33.33Single6PS5S-Propranolol6PS5-β2-S-Propranolol
33.33Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
33.33Single6TPGEMPA6TPG-OX2-EMPA
33.33Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
33.33Single7AROLUF58337ARO-A2A-LUF5833-Na
33.33Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
33.33Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
33.33Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
33.33Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
33.33Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
33.33Single7UL3Famotidine7UL3-H2-Famotidine
33.33Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
33.33Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
33.33Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
33.33Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
33.33Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
33.33Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
33.33Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
33.33Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
33.33Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
33.33Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
33.33Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
33.33Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
33.33Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
33.33Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
33.33Single8IHKAcifran8IHK-HCA3-Acifran
33.33Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
33.33Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
33.33Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
33.33Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
33.33Single8JJ8Formoterol8JJ8-β2-Formoterol
33.33Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
33.33Single8JWY2-1188JWY-A2A-2-118
33.33Single8JWZAB9288JWZ-A2A-AB928-Na
33.33Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
33.33Single8K5CAcipimox8K5C-HCA2-Acipimox
33.33Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
33.33Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
33.33Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
33.33Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
33.33Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
33.33Single8XYIVUF106618XYI-CXCR3-VUF10661
33.33Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
33.33Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
33.33Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
33.33Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
33.33Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
33.33Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
33.33Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
33.33Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
33.33Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
33.33Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
33.33Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
33.33Consensusgrh_offOrthosteric Ligandgnrh1_off
33.33Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
33.33Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
33.33Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
33.33Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
33.33Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.35Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
32.35Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
32.26Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
32.26Single6W25SHU91196W25-MC4-SHU9119-Ca
32.26Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
32.26Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
32.26Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
32.26Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
32.26Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
32.14Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
32.14Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
32.14Single5X93K-87945X93-ETB-K-8794
32.14Single6H7LDobutamine6H7L-β1-Dobutamine
32.14Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
32.14Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
32.14Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
32.14Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
32.14Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
32.14Single7UM4AS26747237UM4-5-HT5A-AS2674723
32.14Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
32.14Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
32.14Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
32.14Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
32.14Single8XVUCXCL28XVU-CXCR2-CXCL2
32.14Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
32.14Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
32.14Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
32.14Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
32.14Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
32.14Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single2Y02Carmoterol2Y02-β1-Carmoterol
32.00Single2Y04Salbutamol2Y04-β1-Salbutamol
32.00Single3EMLZM-2413853EML-A2A-ZM-241385
32.00Single3NY8ICI118-5513NY8-β2-ICI118-551
32.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
32.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
32.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
32.00Single4GBRS-Carazolol4GBR-β2-S-Carazolol
32.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
32.00Single4QKX35V4QKX-β2-35V
32.00Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
32.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
32.00Single5UIGCmpd-15UIG-A2A-Cmpd-1
32.00Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
32.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
32.00Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
32.00Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
32.00Single6PS1Timolol6PS1-β2-Timolol
32.00Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
32.00Single6S0LZM-2413856S0L-A2A-ZM-241385
32.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
32.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
32.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
32.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
32.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
32.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
32.00Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
32.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
32.00Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
32.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
32.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
32.00Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
32.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
32.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
32.00Single8CU6LJ-45178CU6-A2A-LJ-4517
32.00Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
32.00Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
32.00Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
32.00Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
32.00Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
32.00Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
32.00Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
32.00Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
32.00Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
32.00Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
32.00Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
32.00Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
32.00Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
32.00Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
32.00Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
32.00Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
32.00Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
32.00Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
32.00Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
32.00Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
32.00Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
32.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
32.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
32.00Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
32.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
32.00Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
32.00Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
32.00Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
32.00Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
32.00Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
32.00Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
32.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
32.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
32.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
32.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
32.00Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
32.00Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
32.00Consensuscck_offOrthosteric Ligandccka_off
32.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
32.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
32.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
32.00Consensusdopamine_offOrthosteric Ligandd2_off d3_off
32.00Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
32.00Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
31.82Single3OE6IT1t3OE6-CXCR4-IT1t
31.82Single4XNWMRS25004XNW-P2Y1-MRS2500
31.82Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
31.82Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
31.82Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
31.82Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
31.58Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.43Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
31.43Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
31.43Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
31.43Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
31.25Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
31.25Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
31.25Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
31.25Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
31.25Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
31.03Single6KNMJN241-96KNM-Apelin-JN241-9
31.03Single6PT3DPI-2876PT3-δ-DPI-287
31.03Single7SK9CCX6627SK9-ACKR3-CCX662
31.03Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
31.03Single8X5YAstemizole8X5Y-H1-Astemizole
31.03Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
31.03Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
31.03Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
31.03Consensuskisspeptin_onOrthosteric Ligandkiss1_on
31.03Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single2RH1S-Carazolol2RH1-β2-S-Carazolol
30.77Single2Y03Isoprenaline2Y03-β1-Isoprenaline
30.77Single2YCWS-Carazolol2YCW-β1-S-Carazolol
30.77Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
30.77Single5D6LS-Carazolol5D6L-β2-S-Carazolol
30.77Single5IUAQ274563485IUA-A2A-Q27456348-Na
30.77Single5JQHS-Carazolol5JQH-β2-S-Carazolol
30.77Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
30.77Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
30.77Single5TVNLSD5TVN-5-HT2B-LSD
30.77Single5WIUNemonapride5WIU-D4-Nemonapride
30.77Single5WIVNemonapride5WIV-D4-Nemonapride-Na
30.77Single5WQCEMPA5WQC-OX2-EMPA
30.77Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
30.77Single6E67BI1671076E67-β2-BI167107-Gs (fused)
30.77Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
30.77Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
30.77Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
30.77Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
30.77Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
30.77Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
30.77Single6S0QZM-2413856S0Q-A2A-ZM-241385
30.77Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
30.77Single6TP6Filorexant6TP6-OX1-Filorexant
30.77Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
30.77Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
30.77Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
30.77Single7C4SS1P7C4S-S1P3-S1P
30.77Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
30.77Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
30.77Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
30.77Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
30.77Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
30.77Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
30.77Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
30.77Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
30.77Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.77Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.77Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
30.77Single8QOTNanobody-E8QOT-μ-Nanobody-E
30.77Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
30.77Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
30.77Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
30.77Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
30.77Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
30.77Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
30.77Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
30.77Consensusadenosine_offOrthosteric Liganda1_off a2_off
30.77Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
30.77Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
30.77Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
30.77Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
30.77Consensusamine_offonOrthosteric Ligandamine_off amine_on
30.77Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
30.77Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
30.77Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
30.77Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
30.77Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
30.77Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
30.77Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
30.77Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.77Consensustrace-amine_onOrthosteric Ligandta1_on
30.43Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
30.43Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
30.43Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
30.43Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
30.43Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
30.43Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
30.43Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
30.43Single8K5BNiacin8K5B-HCA2-Niacin
30.43Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
30.43Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
30.43Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
30.43Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
30.43Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
30.43Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
30.30Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
30.30Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
30.30Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
30.30Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
30.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
29.73Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
29.73Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
29.63Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
29.63Single4DJHJDTic4DJH-κ-JDTic
29.63Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
29.63Single5D5AS-Carazolol5D5A-β2-S-Carazolol
29.63Single5D5BS-Carazolol5D5B-β2-S-Carazolol
29.63Single6J21Aprepitant6J21-NK1-Aprepitant
29.63Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
29.63Single6TQ7SB-3348676TQ7-OX1-SB-334867
29.63Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
29.63Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
29.63Single7PX4PSB-21137PX4-A2A-PSB-2113
29.63Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
29.63Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
29.63Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
29.63Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
29.63Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
29.63Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
29.63Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
29.63Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
29.63Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
29.63Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
29.63Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
29.63Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
29.63Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
29.63Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
29.63Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
29.63Single8XVLZibotentan8XVL-ETA-Zibotentan
29.63Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
29.63Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
29.63Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
29.63Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
29.63Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
29.63Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
29.63Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
29.63Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
29.63Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
29.63Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.63Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
29.41Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
29.41Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
29.41Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
29.17Single3ODUIT1t3ODU-CXCR4-IT1t
29.17Single3PWHZM-2413853PWH-A2A-ZM-241385
29.17Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
29.17Single4BWBNeurotensin4BWB-NTS1-Neurotensin
29.17Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
29.17Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
29.17Single5WS3EMPA5WS3-OX2-EMPA
29.17Single6AKYMaraviroc6AKY-CCR5-Maraviroc
29.17Single6B73MP11046B73-κ-MP1104
29.17Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
29.17Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
29.17Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
29.17Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
29.17Single6TODEMPA6TOD-OX1-EMPA-Na
29.17Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
29.17Single7BR3Elagolix7BR3-GnRH1-Elagolix
29.17Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
29.17Single7F8ULintitript7F8U-CCKA-Lintitript
29.17Single7F8YDevazepide7F8Y-CCKA-Devazepide
29.17Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
29.17Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
29.17Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
29.17Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
29.17Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
29.17Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
29.17Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
29.17Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
29.17Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
29.17Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
29.17Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
29.17Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
29.17Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
29.17Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
29.17Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
29.17Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
29.17Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
29.17Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
29.17Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
29.17Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
29.17Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
29.17Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
29.17Consensusalpha2_offOrthosteric Ligandalpha2c_off
29.17Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
29.17Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
29.17Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
29.17Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
29.17Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
29.17Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
29.17Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
29.17Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
29.03Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
29.03Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
29.03Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
29.03Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
29.03Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
28.95Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
28.57Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
28.57Single3D4STimolol3D4S-β2-Timolol
28.57Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
28.57Single6A93Risperidone6A93-5-HT2A-Risperidone
28.57Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
28.57Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
28.57Single6ZG4HTL00099366ZG4-M1-HTL0009936
28.57Single7DFPSpiperone7DFP-D2-Spiperone
28.57Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
28.57Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
28.57Single7K15MKD0467K15-BLT1-MKD046-Na
28.57Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
28.57Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
28.57Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
28.57Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
28.57Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
28.57Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
28.57Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
28.57Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
28.57Single8XQJJN2418XQJ-Apelin-JN241
28.57Single8XWACXCL18XWA-CXCR2-CXCL1
28.57Single8XWMCXCL68XWM-CXCR2-CXCL6
28.57Single8XWSCXCL58XWS-CXCR2-CXCL5
28.57Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
28.57Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
28.57Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
28.57Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
28.21Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
28.21Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
28.12Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.00Single2YDOAdenosine2YDO-A2A-Adenosine
28.00Single3REYXAC3REY-A2A-XAC
28.00Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
28.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
28.00Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
28.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
28.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
28.00Single5JTBZM-2413855JTB-A2A-ZM-241385
28.00Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
28.00Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
28.00Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
28.00Single5UVIZM-2413855UVI-A2A-ZM-241385
28.00Single6IQLL7458706IQL-D4-L745870
28.00Single6KUXRS-799486KUX-α2a-RS-79948
28.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
28.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
28.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
28.00Single6TPNHTL66416TPN-OX2-HTL6641
28.00Single6V9SGTPL114036V9S-OX1-GTPL11403
28.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
28.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
28.00Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
28.00Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
28.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
28.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
28.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
28.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
28.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
28.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
28.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
28.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
28.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.00Single7T32ZM-2413857T32-A2A-ZM-241385
28.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
28.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
28.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
28.00Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
28.00Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
28.00Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
28.00Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
28.00Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
28.00Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
28.00Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
28.00Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
28.00Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.00Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.00Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
28.00Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
28.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.00Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.00Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
28.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
28.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
28.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
28.00Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
28.00Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
28.00Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
28.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
28.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
28.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
28.00Consensusa2_offOrthosteric Liganda2a_off
28.00Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
28.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
28.00Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
28.00Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
28.00Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
28.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
28.00Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
28.00Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
28.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
28.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
27.78Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
27.78Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
27.78Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
27.78Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
27.78Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
27.59Single6K1QIRL25006K1Q-ETB-IRL2500
27.59Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
27.59Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
27.59Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
27.59Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
27.59Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
27.59Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
27.59Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.59Single8XWFCXCL38XWF-CXCR2-CXCL3
27.59Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
27.59Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
27.50Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
27.27Single8A2OTheophylline8A2O-A2A-Theophylline-Na
27.27Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
27.27Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
27.27Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
27.27Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
27.27Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
27.27Consensusp2y_offOrthosteric Ligandp2y1_off
27.03Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
26.92Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
26.92Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
26.92Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
26.92Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
26.92Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
26.92Single4QIMANTA XV4QIM-SMO-ANTA XV
26.92Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
26.92Single4YAYZD-71554YAY-AT1-ZD-7155
26.92Single5DHGC-355DHG-NOP-C-35
26.92Single5DHHSB-6121115DHH-NOP-SB-612111
26.92Single5IU8Q274563475IU8-A2A-Q27456347-Na
26.92Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
26.92Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
26.92Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
26.92Single5T04Neurotensin5T04-NTS1-Neurotensin
26.92Single5UENDU1725UEN-A1-DU172
26.92Single6DRXLisuride6DRX-5-HT2B-Lisuride
26.92Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
26.92Single6H7MSalbutamol6H7M-β1-Salbutamol
26.92Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
26.92Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
26.92Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
26.92Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
26.92Single7BU7BI1671077BU7-β1-BI167107
26.92Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
26.92Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
26.92Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
26.92Single7PYRPSB-21157PYR-A2A-PSB-2115
26.92Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
26.92Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
26.92Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
26.92Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
26.92Single7WC7Lisuride7WC7-5-HT2A-Lisuride
26.92Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
26.92Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
26.92Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
26.92Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
26.92Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
26.92Single8JJOAlprenolol8JJO-β2-Alprenolol
26.92Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
26.92Single8JXRLSD8JXR-D1-LSD
26.92Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
26.92Single8RLNLUF58348RLN-A2A-LUF5834
26.92Single8T1WCVN4248T1W-GPR6-CVN424
26.92Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
26.92Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
26.92Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
26.92Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
26.92Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
26.92Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
26.92Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
26.92Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
26.92Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
26.92Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
26.92Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
26.92Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
26.92Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
26.92Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
26.67Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
26.67Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
26.67Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
26.47Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
26.32Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
26.32Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
26.09Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
26.09Single6ME5Agomelatine6ME5-MT1-Agomelatine
26.09Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
26.09Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
26.09Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
26.09Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
26.09Consensus5ht2_onOrthosteric Ligand5ht2b_on
26.09Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.93Single2Y00Dobutamine2Y00-β1-Dobutamine
25.93Single5XPRBosentan5XPR-ETB-Bosentan
25.93Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
25.93Single6PS6Timolol6PS6-β2-Timolol
25.93Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
25.93Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
25.93Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
25.93Single7W41PD1762527W41-BB2-PD176252
25.93Single7WC6LSD7WC6-5-HT2A-LSD
25.93Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
25.93Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
25.93Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
25.93Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
25.93Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
25.93Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
25.93Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
25.93Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
25.93Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
25.93Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
25.93Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
25.93Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
25.93Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
25.93Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
25.93Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
25.93Consensusbombesin_offOrthosteric Ligandbb2_off
25.93Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
25.93Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
25.81Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
25.81Single7QA8Peptide7QA8-STE2-Peptide
25.81Single7QA8Peptide7QA8-STE2-Peptide
25.81Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
25.81Single8IEBA1LYA8IEB-GPR156-A1LYA
25.81Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
25.81Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
25.81Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
25.71Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
25.71Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
25.71Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
25.71Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
25.71Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
25.64Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
25.64Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
25.64Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
25.64Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single3PBLEticlopride3PBL-D3-Eticlopride
25.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
25.00Single5V56TC1145V56-SMO-TC114
25.00Single6HLLCP999946HLL-NK1-CP99994
25.00Single6HLOAprepitant6HLO-NK1-Aprepitant
25.00Single6J20Aprepitant6J20-NK1-Aprepitant
25.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
25.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
25.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
25.00Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
25.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
25.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
25.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
25.00Single7R0CAVP7R0C-V2-AVP-Arrestin2
25.00Single7SRQLSD7SRQ-5-HT2B-LSD
25.00Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
25.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
25.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
25.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
25.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
25.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
25.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
25.00Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
25.00Single8IEBA1LYA8IEB-GPR156-A1LYA
25.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
25.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
25.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
25.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
25.00Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
25.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
25.00Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
25.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
25.00Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
25.00Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
25.00Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
25.00Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
25.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
25.00Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
25.00Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
25.00Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
25.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
25.00Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
25.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
25.00Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
25.00Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
24.32Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
24.24Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
24.24Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
24.24Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
24.14Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
24.14Single4PY02MeSATP4PY0-P2Y12-2MeSATP
24.14Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
24.14Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
24.14Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
24.14Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
24.14Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
24.14Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
24.14Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
24.14Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
24.14Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
24.14Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
24.14Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
24.14Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
24.14Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
24.00Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
24.00Single4QINSAG1.54QIN-SMO-SAG1.5
24.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
24.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
24.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
24.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
24.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
24.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
24.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
24.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
24.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
24.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
24.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
24.00Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
24.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
24.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
24.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
24.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
24.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
24.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
24.00Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
24.00Single8IWESpermidine8IWE-TA9-Spermidine
24.00Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
24.00Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
24.00Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
24.00Single8Y0HVUF114188Y0H-CXCR3-VUF11418
24.00Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
24.00Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
24.00Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
24.00Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
23.68Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
23.68Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
23.53Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
23.33Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
23.33Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
23.33Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
23.33Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
23.33Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.33Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
23.33Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
23.08Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
23.08Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
23.08Single6A94Zotepine6A94-5-HT2A-Zotepine
23.08Single6AQFZM-2413856AQF-A2A-ZM-241385
23.08Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
23.08Single6TP3Nemorexant6TP3-OX1-Nemorexant
23.08Single6VI4JDTic6VI4-κ-JDTic
23.08Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
23.08Single6ZG9GSK10347026ZG9-M1-GSK1034702
23.08Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
23.08Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
23.08Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
23.08Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
23.08Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
23.08Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
23.08Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
23.08Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
23.08Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
23.08Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
23.08Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
23.08Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
23.08Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
23.08Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.08Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
23.08Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
23.08Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
23.08Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single9BJKNaloxone9BJK-μ-Naloxone-NAM
23.08Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
23.08Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
23.08Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
23.08Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
23.08Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
22.86Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
22.73Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
22.73Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
22.73Single8PWNTheophylline8PWN-A2A-Theophylline
22.73Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
22.58Single5EE7MK08935EE7-Glucagon-MK0893
22.58Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
22.58Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.58Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
22.50Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
22.22Single2Y01Dobutamine2Y01-β1-Dobutamine
22.22Single5TGZAM65385TGZ-CB1-AM6538
22.22Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
22.22Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
22.22Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
22.22Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
22.22Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
22.22Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
22.22Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
22.22Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
22.22Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
22.22Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
22.22Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
22.22Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
22.22Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
22.22Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
22.22Single8X63Mepyramine8X63-H1-Mepyramine
22.22Single8X64Desloratadine8X64-H1-Desloratadine
22.22Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
22.22Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
22.22Single9IYAONO-97105319IYA-GPR55-ONO-9710531
22.22Consensusalpha2_onOrthosteric Ligandalpha2b_on
22.22Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
22.22Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
22.22Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
22.22Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
22.22Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
22.22Consensusblt_onOrthosteric Ligandblt1_on
22.22Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
22.22Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
22.22Consensushistamine_offOrthosteric Ligandh1_off
22.22Consensusleukotriene_onOrthosteric Ligandblt_on
22.22Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
21.95Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
21.95Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
21.95Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
21.88Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
21.88Single8IEIA1LYA8IEI-GPR156-A1LYA
21.88Single8IEPA1LYA8IEP-GPR156-A1LYA
21.88Single8IEPA1LYA8IEP-GPR156-A1LYA
21.88Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
21.88Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
21.88Single8KIGSHU91198KIG-MC3-SHU9119-Ca
21.74Single3OE8IT1t3OE8-CXCR4-IT1t
21.74Single3RFMCaffeine3RFM-A2A-Caffeine
21.74Single6TQ9SB-4081246TQ9-OX1-SB-408124
21.74Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
21.74Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
21.74Single9CHUNoradrenaline9CHU-β2-Noradrenaline
21.74Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
21.74Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
21.62Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
21.62Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
21.62Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
21.62Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
21.43Single4JKVTaladegib4JKV-SMO-Taladegib
21.43Single4NTJAZD12834NTJ-P2Y12-AZD1283
21.43Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
21.43Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
21.43Single6LUQHaloperidol6LUQ-D2-Haloperidol
21.43Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
21.43Single7SINNPS-21437SIN-CaS-NPS-2143
21.43Single7SINNPS-21437SIN-CaS-NPS-2143
21.43Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
21.43Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
21.43Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
21.43Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
21.43Single8ZMFA1L108ZMF-5-HT2C-A1L10
21.43Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
21.43Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
21.43Consensusblt_offOrthosteric Ligandblt1_off
21.43Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
21.21Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
21.21Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
21.21Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
21.05Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
21.05Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
21.05Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
21.05Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
21.05Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
20.83Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
20.83Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
20.83Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
20.83Single7WC5Psilocin7WC5-5-HT2A-Psilocin
20.83Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
20.83Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
20.83Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
20.83Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
20.83Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
20.83Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
20.83Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
20.83Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
20.83Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
20.83Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
20.83Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
20.83Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
20.83Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
20.69Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
20.69Single4U15Tiotropium4U15-M3-Tiotropium
20.69Single5TZRMK86665TZR-FFA1-MK8666
20.69Single5V54Methiothepin5V54-5-HT1B-Methiothepin
20.69Single5V57TC1145V57-SMO-TC114
20.69Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
20.69Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
20.69Single6E59L-7607356E59-NK1-L-760735
20.69Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
20.69Single6OL9Tiotropium6OL9-M5-Tiotropium
20.69Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
20.69Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
20.69Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
20.69Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
20.69Consensus5ht1_offOrthosteric Ligand5ht1b_off
20.69Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
20.69Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
20.69Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
20.69Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
20.69Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
20.69Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
20.69Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
20.69Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
20.69Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
20.69Consensustachykinin_offOrthosteric Ligandnk1_off
20.00Single4N4WSANT-14N4W-SMO-SANT-1
20.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
20.00Single5CXVTiotropium5CXV-M1-Tiotropium
20.00Single5L7IVismodegib5L7I-SMO-Vismodegib
20.00Single6CM4Risperidone6CM4-D2-Risperidone
20.00Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
20.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
20.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
20.00Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
20.00Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
20.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
20.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
20.00Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
20.00Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
20.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
20.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
20.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
20.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
20.00Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
20.00Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
20.00Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
20.00Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
20.00Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
20.00Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
20.00Single9B9Y7DY9B9Y-CB1-7DY
20.00Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
20.00Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
20.00Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
20.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
20.00Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
19.57Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
19.44Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
19.35Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
19.35Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
19.35Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single8XVJMacitentan8XVJ-ETA-Macitentan
19.23Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
19.23Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
19.23Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
19.23Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
19.23Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
19.23Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
19.23Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
19.23Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
19.23Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
19.23Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
19.23Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
19.23Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
19.23Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
19.23Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
19.23Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
19.23Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
19.23Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
19.23Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
19.23Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.23Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
19.23Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
19.23Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
19.23Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
19.23Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
19.23Consensusangiotensin_offOrthosteric Ligandat1_off
19.23Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
19.23Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
19.23Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
19.23Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
19.23Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
19.23Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
19.23Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
19.23Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
19.23Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
19.23Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
19.23Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
19.05Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
18.92Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
18.75Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
18.75Single8IEIA1LYA8IEI-GPR156-A1LYA
18.75Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
18.75Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
18.75Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
18.52Single3RZECidoxepin3RZE-H1-Cidoxepin
18.52Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
18.52Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
18.52Single6TPKRetosiban6TPK-OT-Retosiban
18.52Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
18.52Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
18.52Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
18.52Single6ZINSR486926ZIN-NTS1-SR48692
18.52Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
18.52Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
18.52Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
18.52Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
18.52Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
18.52Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
18.52Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
18.52Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
18.52Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
18.52Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
18.52Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
18.52Consensusvasop-oxy_offOrthosteric Ligandot_off
18.42Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
18.42Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
18.18Single5MZPCaffeine5MZP-A2A-Caffeine-Na
18.18Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
18.18Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
17.95Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
17.86Single4DAJTiotropium4DAJ-M3-Tiotropium
17.86Single4MQSIperoxo4MQS-M2-Iperoxo
17.86Single4U14Tiotropium4U14-M3-Tiotropium
17.86Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
17.86Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
17.86Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
17.86Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
17.86Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
17.86Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
17.86Single6GPSMK08126GPS-CCR2-MK0812
17.86Single7F83PF-051904577F83-Ghrelin-PF-05190457
17.86Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
17.86Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
17.86Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
17.86Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
17.86Single7YXAONO-54306087YXA-S1P5-ONO-5430608
17.86Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.86Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
17.86Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
17.86Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
17.86Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
17.86Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
17.86Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
17.86Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
17.86Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
17.39Single7WC4Serotonin7WC4-5-HT2A-Serotonin
17.39Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
17.39Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
17.24Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
17.24Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
17.24Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
17.24Single6GPXMK08126GPX-CCR2-MK0812
17.24Single6HLPNetupitant6HLP-NK1-Netupitant
17.24Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
17.24Single6Z4SSR486926Z4S-NTS1-SR48692
17.24Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
17.24Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
17.24Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
17.24Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.24Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
17.24Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
17.24Consensusep_offOrthosteric Ligandep4_off
17.24Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
17.24Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
17.24Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
17.24Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.07Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
16.67Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
16.67Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
16.67Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
16.67Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
16.67Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
16.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
16.67Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
16.67Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
16.67Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
16.67Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
16.67Single8EA0Iperoxo8EA0-M3-Iperoxo
16.67Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
16.67Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
16.67Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
16.67Single9BJKNAM9BJK-μ-Naloxone-NAM
16.67Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
16.67Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
16.67Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
16.67Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
16.67Consensussensory_onOrthosteric Ligandopsins_on
16.22Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
16.22Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
16.13Single5X33BIIL2605X33-BLT1-BIIL260
16.13Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
16.13Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
16.13Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.13Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
16.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
16.00Single3UZAGTPL92363UZA-A2A-GTPL9236
16.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
16.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
16.00Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
16.00Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
16.00Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
16.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.00Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
16.00Single8JPSCCL78JPS-ACKR1-CCL7
16.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
16.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
16.00Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
16.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
16.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
16.00Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
16.00Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
16.00Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
15.62Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
15.62Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
15.62Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
15.62Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
15.62Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
15.38Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
15.38Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
15.38Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
15.38Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
15.38Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
15.38Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
15.38Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
15.38Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
15.38Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
15.38Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
15.38Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
15.38Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
15.38Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
15.15Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
14.81Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
14.81Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
14.81Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
14.81Single5U09Taranabant5U09-CB1-Taranabant
14.81Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
14.81Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
14.81Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.81Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.81Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
14.81Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
14.81Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
14.81Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
14.81Single9BA0A1AKN9BA0-CB1-A1AKN
14.71Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
14.29Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
14.29Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
14.29Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
14.29Single7VODCariprazine7VOD-5-HT2A-Cariprazine
14.29Single7VV6C48/807VV6-MRGPRX2-C48/80
14.29Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
14.29Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
14.29Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
14.29Single8K2WAMG4878K2W-CXCR3-AMG487
14.29Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
14.29Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
14.29Consensusopsins_offOrthosteric Ligandrhodopsin_off
14.29Consensussensory_offOrthosteric Ligandopsins_off
13.79Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
13.79Single5DSGTiotropium5DSG-M4-Tiotropium
13.79Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
13.79Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
13.79Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
13.79Single9B9ZA1AKO9B9Z-CB1-A1AKO
13.79Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
13.79Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
13.79Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
13.64Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
13.51Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
13.33Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
13.33Single5CGCHTL142425CGC-mGlu5-HTL14242
13.33Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
13.33Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
13.33Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
13.33Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
13.33Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
13.33Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
13.33Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
13.33Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
13.33Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
13.33Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
12.90Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
12.90Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
12.50Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
12.50Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
12.50Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
12.50Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
12.50Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
12.50Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single5CGDHTL142425CGD-mGlu5-HTL14242
12.12Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
12.12Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
12.12Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
12.00Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
11.76Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
11.76Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
11.54Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
11.54Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
11.54Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
11.54Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
11.54Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
11.54Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.54Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
11.54Consensusgi_sensoryOrthosteric Ligandgi_opsins
11.54Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
11.54Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
11.11Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
11.11Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
11.11Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
11.11Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
11.11Single6LI0C176LI0-GPR52-C17
11.11Single7UL2SR486927UL2-NTS1-SR48692-Na
11.11Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
11.11Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.11Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
11.11Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
11.11Consensusneurotensin_offOrthosteric Ligandnts1_off
11.11Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
10.71Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
10.71Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
10.71Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
10.71Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
10.71Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
10.71Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
10.71Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
10.71Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
10.34Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.00Single6IIVDaltroban6IIV-TP-Daltroban
10.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
9.68Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
9.68Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.68Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
9.68Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
9.68Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
9.68Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
9.68Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
9.68Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
9.38Single7P2L4YI7P2L-mGlu5-4YI
9.38Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
9.38Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
9.09Single6IIURamatroban6IIU-TP-Ramatroban
8.33Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
8.33Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
8.00Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
8.00Single8HS2Fab0468HS2-GPR20-Fab046
8.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
8.00Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
7.69Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
7.69Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
7.41Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
7.14Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
7.14Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
7.14Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
7.14Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
7.14Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
6.67Single6FFIMMPEP6FFI-mGlu5-MMPEP
6.67Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
6.45Single6FFHFenobam6FFH-mGlu5-Fenobam
6.25Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
6.06Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
6.06Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
6.06Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
5.71Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
5.56Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
5.41Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
5.26Single7SHEPI; PE7SHE-GPR158-PI; PE
4.55Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.55Single6D35Cholesterol6D35-SMO-Cholesterol
4.55Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.55Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.55Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
4.55Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
4.55Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.55Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.55Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.55Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
4.55Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
4.55Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
4.55Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.55Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.55Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.55Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.55Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
4.55Single7DTTCa7DTT-CaS-Ca-Ca
4.55Single7DTTCa7DTT-CaS-Ca-Ca
4.55Single7DTUTryptophan7DTU-CaS-Tryptophan
4.55Single7DTUTryptophan7DTU-CaS-Tryptophan
4.55Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.55Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.55Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.55Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.55Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.55Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.55Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.55Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.55Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
4.55Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.55Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.55Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.55Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.55Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.55Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.55Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
4.55Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
4.55Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.55Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.55Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.55Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.55Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.55Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.55Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.55Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.55Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.55Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.55Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.55Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.55Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.55Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
4.55Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.55Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.55Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.55Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.55Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.55Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.55Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
4.55Single7XW7K1-707XW7-TSH-K1-70
4.55Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.55Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.55Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.55Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.55Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.55Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.55Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.55Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.55Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.55Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.55Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.55Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.55Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
4.55Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.55Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.55Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.55Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.55Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
4.55Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
4.55Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.55Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.55Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.55Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.55Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.55Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.55Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.55Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.55Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.55Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
4.55Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
4.55Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.55Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.55Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.55Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.55Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.55Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.55Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.55Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.55Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.55Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.55Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.55Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.55Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.55Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.55Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.55Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.55Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.55Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.55Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.55Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.55Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
4.55Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
4.55Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
4.55Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
4.55Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
4.55Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
4.55Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.55Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.55Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single8WVXNorrin8WVX-LGR4-Norrin
4.55Single8WVYNorrin8WVY-LGR4-Norrin
4.55Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.55Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.55Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.55Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.55Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.55Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.55Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
4.55Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.55Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.55Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.55Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.55Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.55Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.55Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.55Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.55Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.55Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.55Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.55Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.55Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.55Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.55Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.55Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.55Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.55Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.55Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.55Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.35Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.35Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.35Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.35Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.35Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.35Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.35Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.35Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.35Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.35Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.35Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.35Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.17Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
4.17Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.17Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
4.00Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
4.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
4.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.00Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
3.85Single5L7DCholesterol5L7D-SMO-Cholesterol
3.85Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
3.85Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
3.70Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
3.57Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
3.57Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
3.45Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
3.33Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
3.23Single8IYXYL-3658IYX-GPR34-YL-365
3.03Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.03Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
2.86Single7SHEPI; PE7SHE-GPR158-PI; PE
2.78Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.63Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.63Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.56Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.50Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.50Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.44Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.27Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
gi_cck 7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
gi_apelin 8XZH-Apelin-MM07-Gi1/β1/γ2
7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
8XZJ-Apelin-WN353-Gi1/β1/γ2
8XZF-Apelin-WN561-Gi1/β1/γ2
8XZG-Apelin-Apelin-13-Gi1/β1/γ2
gi_compl-pept 8HK5-C5a1-Complement C5-Gi1/β1/γ2
8IA8-C3aB-E7 peptide-Gi1/β1/γ2
7Y66-C5a1-BM213-Gi1/β1/γ2
7Y67-C5a1-C089 peptide-Gi1/β1/γ2
8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
gi_endothelin 8IY5-ETB-Endothelin-1-Gi1/β1/γ2
8HBD-ETB-IRL1620-Gi1/β1/γ2
gi_formylpeptide 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
gi_galanin 7WQ3-GAL1-Galanin-Gi1/β1/γ2
gi_ghrelin 7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
gi_npy 8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
gi_neurotensin 6OSA-NTS1-JMV449-Gi1/β1/γ2
7L0S-NTS1-Neurotensin-Gi1/β1/γ1
gi_opioid 8F7R-μ-Endomorphin-Gi1/β1/γ2
8EF5-μ-Fentanyl-Gi1/β1/γ2
7SCG-μ-FH210-Gi1/β1/γ2
7T2H-μ-Lofentanil-Gi1/β1/γ2
7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
8DZP-κ-momSalB-Gi1/β1/γ2
8EF6-μ-Morphine-Gi1/β1/γ2
8F7X-NOP-Nociceptin-Gi1/β1/γ2
8EFB-μ-Oliceridine-Gi1/β1/γ2
7U2L-μ-PubChem 163201242-Gi1/β1/γ2
8EFO-μ-PZM21-Gi1/β1/γ2
8EFL-μ-SR17018-Gi1/β1/γ2
8F7Q-μ-β-Endorphin-Gi1/β1/γ2
7U2K-μ-C6-guano-Gi1/β1/γ2
8EFQ-μ-Damgo-Gi1/β1/γ2
8F7S-δ-Deltorphin-Gi1/β1/γ2
8F7W-κ-Dynorphin-Gi1/β1/γ2
gi_orexin 7SQO-OX2-TAK-925-Gi1/β1/γ2
gi_relaxin 7YK7-RXFP4-DC591053-Gi2/β1/γ2
7YJ4-RXFP4-INSL5-Gi2/β1/γ2
7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
gi_somatostatin 7WIC-SST2-Somatostatin-14-Gi1/β1/γ2
7XMS-SST4-Somatostatin-14-Gi1/β1/γ2
8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
7XMT-SST4-J-2156-Gi1/β1/γ2
7WIG-SST2-L-054,264-Gi1/β1/γ2
8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
7YAE-SST2-Octreotide-Gi1/β1/γ2
7YAC-SST2-Paltusotine-Gi1/β1/γ2
Net Summary
Imin 2.74166
Number of Linked Nodes 1098
Number of Links 1300
Number of Hubs 203
Number of Links mediated by Hubs 777
Number of Communities 21
Number of Nodes involved in Communities 264
Number of Links involved in Communities 387
Path Summary
Number Of Nodes in MetaPath 112
Number Of Links MetaPath 111
Number of Shortest Paths 2504294
Length Of Smallest Path 3
Average Path Length 34.9465
Length of Longest Path 67
Minimum Path Strength 0.118205
Average Path Strength 5.09134
Maximum Path Strength 21.469
Minimum Path Correlation 0.700167
Average Path Correlation 0.969533
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.69492
Average % Of Corr. Nodes 31.5274
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.3028
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gi_class-agi_peptide
gi_sensory
gi_alicarboxylic
gi_amine
gi_lipid
gi_nucleotide
gi_protein



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download gi_peptide.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.