Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Q19 5.71754134
2A:A:R38 7.5225404
3A:A:H41 5.0054106
4A:A:L45 4.91408
5A:A:S51 2.416509
6A:A:F219 6.185717108
7A:A:H220 11.76417
8A:A:F222 9.324517
9A:A:K233 6.32333619
10A:A:W234 7.634519
11A:A:C237 3.71418
12A:A:Y253 10.01254198
13A:A:F273 4.8756179
14A:A:W277 9.9145176
15A:A:W281 10.1133615
16A:A:Y311 16.67406
17A:A:F315 10.124506
18A:A:Y318 8.3875406
19A:A:E330 9.564113
20A:A:D331 7.3875404
21A:A:V334 5.1545114
22A:A:K338 10.2054115
23A:A:F340 9.73507
24A:A:R342 6.5985114
25A:A:F345 9.2725408
26A:A:Y360 8.845208
27A:A:P361 5.25754115
28A:A:F363 9.4165115
29A:A:N371 7.43409
30A:A:R373 5.09254105
31A:A:F376 6.818758108
32A:A:R385 7.4465205
33A:A:L388 4.29408
34A:A:L394 4.13408
35B:B:L14 5.50254148
36B:B:R22 6.86446
37B:B:T34 4.1175405
38B:B:V40 2.794503
39B:B:L51 8.06429
40B:B:H54 7.34143729
41B:B:K57 9.3125419
42B:B:Y59 8.025418
43B:B:M61 3.9525426
44B:B:W63 6.26667627
45B:B:L70 6.6525425
46B:B:V71 3.575408
47B:B:Q75 8.54419
48B:B:D76 6.38629
49B:B:L79 4.978587
50B:B:I80 8428
51B:B:I81 4.596587
52B:B:W82 9.56729
53B:B:D83 7.93754138
54B:B:K89 5.882529
55B:B:I93 5.3775487
56B:B:L95 5.1575488
57B:B:W99 9.87167619
58B:B:Y105 4.685606
59B:B:V112 4.695488
60B:B:C121 4.93418
61B:B:I123 3.36406
62B:B:Y124 5686
63B:B:V133 4.265484
64B:B:H142 7.944519
65B:B:Y145 6.5175818
66B:B:L146 4.765617
67B:B:C149 3.706518
68B:B:F151 6.012509
69B:B:L152 4.295403
70B:B:Q156 4.835405
71B:B:I157 5.622517
72B:B:V158 3.59405
73B:B:T159 5.89619
74B:B:S160 4.4475456
75B:B:D163 7.632519
76B:B:L168 4.3225456
77B:B:W169 8.92714718
78B:B:F180 7.842557
79B:B:H183 9.402559
80B:B:D186 5.644519
81B:B:V187 5.0875459
82B:B:M188 5.2675418
83B:B:V200 7.5825446
84B:B:S201 4.915459
85B:B:C204 6.432517
86B:B:D205 7.448559
87B:B:K209 12.38456
88B:B:L210 5.908545
89B:B:W211 9.592558
90B:B:Q220 8.19447
91B:B:F222 9.6925448
92B:B:H225 9.80833649
93B:B:D228 8.196519
94B:B:I232 6.485448
95B:B:F234 6.4505
96B:B:F235 5.515676
97B:B:P236 6.39477
98B:B:N237 7.355475
99B:B:F241 8.78546
100B:B:T243 6.6575448
101B:B:D246 6.85419
102B:B:D247 9.585449
103B:B:R251 7.94648
104B:B:F253 7.43646
105B:B:D254 4.18409
106B:B:R256 8.7275409
107B:B:D258 9.188547
108B:B:M262 5.2475404
109B:B:Y264 7.194575
110B:B:F278 7.38477
111B:B:L285 5.288576
112B:B:Y289 6.684577
113B:B:D290 6.552516
114B:B:C294 4.1075495
115B:B:N295 8.0375476
116B:B:W297 6.74578
117B:B:D298 8.01254229
118B:B:K301 6.15254225
119B:B:H311 8.61599
120B:B:R314 12.028518
121B:B:L318 3.25596
122B:B:M325 5.14833625
123B:B:T329 5.7575498
124B:B:W332 10.3157719
125B:B:D333 8.0825499
126B:B:L336 5.324527
127B:B:K337 7.6425496
128B:B:W339 10.032599
129B:B:N340 8.99429
130G:G:V16 4.45754147
131G:G:E22 5.6425449
132G:G:A23 2.355408
133G:G:R27 6.835448
134G:G:Y40 9.555476
135G:G:D48 5.278509
136G:G:L51 3.53506
137G:G:V54 4.555426
138G:G:N59 6.426529
139G:G:P60 7.535429
140G:G:F61 6.3525828
141R:R:R34 5.198505
142R:R:L38 4.736536
143R:R:F41 6.57833637
144R:R:L42 6.86438
145R:R:S45 3.9975439
146R:R:N49 6.9675409
147R:R:K59 6.075407
148R:R:L63 7.93254128
149R:R:F69 5.734268
150R:R:L73 6.29439
151R:R:D77 8.3075439
152R:R:I81 4.975438
153R:R:W97 3.80833609
154R:R:L99 5.915407
155R:R:L107 4.074277
156R:R:H112 5.7325468
157R:R:L113 4.23408
158R:R:F114 6.472506
159R:R:F116 13.0275469
160R:R:S118 4.8175439
161R:R:Y130 6.954158
162R:R:I133 4.9475408
163R:R:L137 5.4385107
164R:R:Y139 6.094508
165R:R:W156 6.86439
166R:R:P165 8.284569
167R:R:P166 4.228568
168R:R:W170 5.938566
169R:R:M184 7.115467
170R:R:W186 9.04767
171R:R:Y192 6.24568
172R:R:F200 9.5408
173R:R:P204 4.35439
174R:R:Y212 5.65833639
175R:R:Q222 5.7825408
176R:R:Y393 8.97254287
177R:R:Y408 5.486539
178R:R:L412 5.0525439
179R:R:Q446 6.172539
180R:R:C447 4.775439
181R:R:H450 9.02333639
182R:R:Y454 7.536509
183R:R:H458 8.25129
184R:R:M468 2.81407
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D76 B:B:K78 12.08665.53YesNo098
2B:B:D83 B:B:R68 29.102716.68YesNo085
3B:B:R68 B:B:Y85 29.209122.64NoNo054
4B:B:Y85 G:G:P60 14.001111.13NoYes249
5B:B:M325 G:G:P60 13.89356.71YesYes259
6B:B:M325 G:G:P49 35.42373.35YesNo057
7G:G:D48 G:G:P49 35.31474.83YesNo097
8B:B:S279 G:G:D48 32.42118.83NoYes099
9B:B:L284 B:B:S279 32.3664.5NoNo059
10B:B:L284 B:B:V296 33.55575.96NoNo055
11B:B:L286 B:B:V296 33.39994.47NoNo075
12B:B:L286 B:B:L318 33.49954.15NoYes076
13B:B:L318 B:B:T329 1002.95YesYes968
14B:B:H311 B:B:T329 99.12148.21YesYes998
15B:B:D333 B:B:H311 98.76985.04YesYes999
16B:B:D312 B:B:D333 98.48995.32NoYes059
17B:B:D312 R:R:K59 98.36825.53NoYes057
18R:R:E464 R:R:K59 96.033612.15NoYes097
19R:R:E464 R:R:L62 95.90937.95NoNo099
20R:R:L62 R:R:T460 95.7852.95NoNo098
21R:R:H458 R:R:T460 95.0038.21YesNo1298
22A:A:Y391 R:R:H458 56.184610.89NoYes049
23A:A:Y391 R:R:I133 34.86024.84NoYes048
24R:R:I133 R:R:S132 16.47633.1YesNo088
25B:B:Y85 G:G:F61 15.32299.28NoYes248
26B:B:M325 G:G:F61 18.63943.73YesYes258
27A:A:Y37 B:B:D76 12.14793.45NoYes249
28A:A:R42 A:A:Y37 12.258119.55NoNo094
29A:A:F222 A:A:R42 12.48756.41YesNo079
30A:A:H387 R:R:S132 10.92526.97NoNo088
31A:A:H387 A:A:I383 10.53473.98NoNo088
32A:A:H41 A:A:I383 10.19493.98YesNo068
33A:A:L388 R:R:I133 18.30315.71YesYes088
34A:A:L388 A:A:L394 17.32834.15YesYes088
35A:A:D378 A:A:Y360 11.464312.64NoYes078
36A:A:L394 R:R:L226 10.03824.15YesNo085
37B:B:W332 B:B:Y59 70.1825.79YesYes198
38B:B:M101 B:B:Y59 65.616210.78NoYes198
39B:B:M101 B:B:Y145 65.51679.58NoYes198
40A:A:R231 A:A:W234 48.26487NoYes099
41A:A:L272 A:A:R231 48.03848.5NoNo089
42A:A:W281 B:B:W332 37.42335.62YesYes159
43B:B:R314 B:B:W332 37.130824.99YesYes189
44A:A:F246 A:A:L272 47.58586.09NoNo098
45A:A:F246 A:A:V248 14.42615.24NoNo097
46A:A:F246 A:A:F273 32.93694.29NoYes099
47A:A:F345 A:A:V248 13.95455.24YesNo087
48A:A:F273 A:A:F345 13.98527.5YesYes098
49A:A:F345 A:A:L289 10.613714.61YesNo089
50A:A:L289 A:A:L291 10.13125.54NoNo098
51A:A:F345 A:A:L270 16.87459.74YesNo086
52A:A:E344 A:A:L270 24.59635.3NoNo056
53A:A:E344 A:A:F340 23.15399.33NoYes057
54A:A:W281 B:B:D290 37.71310.05YesYes156
55B:B:D290 B:B:R314 37.242510.72YesYes168
56A:A:F363 A:A:K338 10.183316.13YesYes1155
57A:A:Y391 R:R:R129 32.17821.61NoNo049
58B:B:D83 B:B:L69 28.33654.07YesNo085
59B:B:L69 B:B:Y105 28.23645.86NoYes056
60B:B:H62 B:B:Y105 28.1453.27NoYes066
61B:B:H62 B:B:R150 27.987920.31NoNo066
62B:B:C148 B:B:R150 27.83052.79NoNo066
63B:B:C148 B:B:S160 21.2613.44NoYes566
64B:B:S160 B:B:V187 20.95396.46YesYes569
65B:B:H183 B:B:V187 18.94615.54YesYes599
66B:B:H183 B:B:K209 17.794917.03YesYes596
67B:B:K209 B:B:T221 17.119713.51YesNo067
68B:B:T221 G:G:E22 16.99747.06NoYes079
69B:B:C271 B:B:D290 75.29333.11NoYes056
70B:B:C271 B:B:Y289 74.83615.38NoYes057
71B:B:W297 B:B:Y289 37.71367.72YesYes787
72B:B:W297 B:B:Y264 37.626410.61YesYes785
73B:B:G162 B:B:Y145 24.559210.14NoYes198
74B:B:G162 B:B:S161 24.38143.71NoNo199
75B:B:H142 B:B:S161 22.9113.95YesNo199
76B:B:H142 B:B:W169 11.86526.35YesYes198
77B:B:V112 B:B:Y105 10.40843.79YesYes086
78B:B:I93 B:B:L79 12.18337.14YesYes877
79B:B:I93 B:B:P94 11.12623.39YesNo075
80B:B:I123 B:B:Y111 10.92033.63YesNo064
81B:B:L318 B:B:S275 70.87213YesNo068
82B:B:A231 B:B:S275 70.88933.42NoNo058
83B:B:A231 B:B:V276 70.91993.39NoNo056
84B:B:L285 B:B:V276 70.98024.47YesNo066
85B:B:I273 B:B:Y289 36.48049.67NoYes067
86B:B:C250 B:B:I273 36.36676.55NoNo086
87B:B:C250 B:B:L285 36.31243.17NoYes786
88B:B:L285 B:B:Y264 37.14734.69YesYes765
89R:R:H458 R:R:I461 32.76967.95YesNo1298
90R:R:G455 R:R:I461 33.14525.29NoNo098
91R:R:G455 R:R:L52 32.98483.42NoNo099
92R:R:L52 R:R:L74 32.8274.15NoNo099
93R:R:L74 R:R:N49 32.51728.24NoYes099
94R:R:N49 R:R:S45 32.06384.47YesYes099
95R:R:I81 R:R:S45 13.60764.64YesYes389
96R:R:I81 R:R:L42 16.59555.71YesYes388
97R:R:L38 R:R:L42 15.7965.54YesYes368
98R:R:L38 R:R:V88 10.37972.98YesNo368
99R:R:T91 R:R:V88 14.37353.17NoNo078
100R:R:L99 R:R:T91 13.82312.95YesNo077
101R:R:C448 R:R:S45 18.33073.44NoYes389
102R:R:C448 R:R:F41 17.82696.98NoYes387
103R:R:F41 R:R:L38 12.28798.53YesYes376
104R:R:L38 R:R:V89 17.29762.98YesNo367
105R:R:S92 R:R:V89 16.53043.23NoNo367
106R:R:R34 R:R:S92 16.15243.95YesNo056
107R:R:R129 R:R:Y454 24.6838.23NoYes099
108R:R:L73 R:R:Y454 14.06154.69YesYes099
109R:R:H450 R:R:Q446 15.085411.13YesYes399
110R:R:F443 R:R:Q446 12.47954.68NoYes089
111R:R:F443 R:R:Y415 11.752511.35NoNo089
112R:R:W186 R:R:Y415 10.29056.75YesNo679
113B:B:K78 B:B:P94 11.31655.02NoNo085
114A:A:W234 B:B:Y145 42.41325.79YesYes198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8W8Q
Class A
SubFamily Orphan
Type Orphan
SubType GPR101
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.89
Date 2024-01-03
D.O.I. doi.org/10.1038/s41589-023-01456-6
Net Summary
Imin 2.95
Number of Linked Nodes 870
Number of Links 1096
Number of Hubs 184
Number of Links mediated by Hubs 662
Number of Communities 28
Number of Nodes involved in Communities 272
Number of Links involved in Communities 399
Path Summary
Number Of Nodes in MetaPath 115
Number Of Links MetaPath 114
Number of Shortest Paths 2176826
Length Of Smallest Path 3
Average Path Length 34.3687
Length of Longest Path 61
Minimum Path Strength 1.4
Average Path Strength 6.90485
Maximum Path Strength 25.04
Minimum Path Correlation 0.71
Average Path Correlation 0.984786
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.32558
Average % Of Corr. Nodes 38.3694
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.1086
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8W8Q_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGAGESGK 
NTIVKQFSG IFETKFQVD KVNFHMFDV GAQRDERRK WIQCFNDVT 
AIIFVVASS SYNRLQAAL KLFDSIWNN KWLRDTSVI LFLNKQDLL 
AEKVLAGKS KIEDYFPEF ARYTTPEDA TPEPGEDPR VTRAKYFIR 
DEFLRISTA SGDGRHYCY PHFTCAVDT ENIRRVFND CRDIIQRMH 
LRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8W8Q_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8W8Q_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ96P66
Sequence
>8W8Q_Chain_R
PISLAHGII RSTVLVIFL AASFVGNIV LALVLQRKP QLLQVTNRF 
IFNLLVTDL LQISLVAPW VVATSVPLF WPLNSHFCT ALVSLTHLF 
AFASVNTIV VVSVDRYLS IIHPLSYPS KMTQRRGYL LLYGTWIVA 
ILQSTPPLY GWGQAAFDE RNALCSMIW GASPSYTIL SVVSFIVIP 
LIVMIACYS VVFCAARRQ HALLYNRCY QCKAAKVIF IIIFSYVLS 
LGPYCFLAV LAVWVDVET QVPQWVITI IIWLFFLQC CIHPYVYGY 
MHKTIKKEI QDMLKKFF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8W8RAOrphanOrphanGPR101Homo sapiens-AA-14chim(NtGi1-Gs)/β1/γ23.32024-01-03doi.org/10.1038/s41589-023-01456-6
8W8R (No Gprot) AOrphanOrphanGPR101Homo sapiens-AA-143.32024-01-03doi.org/10.1038/s41589-023-01456-6
8W8SAOrphanOrphanGPR101Homo sapiens-AA-14-3.32024-01-03doi.org/10.1038/s41589-023-01456-6
8W8QAOrphanOrphanGPR101Homo sapiens--Gs/β1/γ22.892024-01-03doi.org/10.1038/s41589-023-01456-6
8W8Q (No Gprot) AOrphanOrphanGPR101Homo sapiens--2.892024-01-03doi.org/10.1038/s41589-023-01456-6




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8W8Q.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.