Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:R34 5.198506
2R:R:L38 4.736537
3R:R:F41 6.57833637
4R:R:L42 6.86438
5R:R:S45 3.9975438
6R:R:N49 6.9675409
7R:R:K59 6.075407
8R:R:L63 7.93254128
9R:R:F69 5.734178
10R:R:L73 6.29439
11R:R:D77 8.3075439
12R:R:I81 4.975438
13R:R:W97 3.80833609
14R:R:L99 5.915407
15R:R:L107 4.074187
16R:R:H112 5.7325468
17R:R:L113 4.23408
18R:R:F114 6.472507
19R:R:F116 13.0275469
20R:R:S118 4.8175439
21R:R:Y130 6.954139
22R:R:I133 4.9475408
23R:R:L137 5.4385107
24R:R:Y139 6.094509
25R:R:W156 6.86439
26R:R:P165 8.284568
27R:R:P166 4.228568
28R:R:W170 5.938567
29R:R:M184 7.115467
30R:R:W186 9.04767
31R:R:Y192 6.24568
32R:R:F200 9.5408
33R:R:P204 4.35439
34R:R:Y212 5.65833639
35R:R:Q222 5.7825408
36R:R:Y408 5.486539
37R:R:L412 5.0525439
38R:R:Q446 6.172539
39R:R:C447 4.775439
40R:R:H450 9.02333639
41R:R:Y454 7.536509
42R:R:H458 8.25129
43R:R:M468 2.81407
44A:A:Q19 5.71754154
45A:A:R38 7.5225404
46A:A:H41 5.0054106
47A:A:L45 4.91408
48A:A:S51 2.5925409
49A:A:F219 6.185717108
50A:A:H220 10.6575417
51A:A:F222 8.87517
52A:A:K233 6.32333619
53A:A:W234 7.634519
54A:A:C237 3.71418
55A:A:Y253 9.024228
56A:A:F273 4.8756209
57A:A:W277 9.9145206
58A:A:W281 10.1133615
59A:A:F315 12.922506
60A:A:Y318 8.3875406
61A:A:E330 9.564113
62A:A:D331 7.3875404
63A:A:V334 5.1545114
64A:A:K338 10.2054115
65A:A:F340 9.73507
66A:A:R342 6.5985114
67A:A:F345 7.92508
68A:A:Y360 8.845198
69A:A:P361 5.25754115
70A:A:F363 9.4165115
71A:A:N371 7.43409
72A:A:R373 5.09254105
73A:A:F376 6.818758108
74A:A:R385 7.4465195
75A:A:L388 4.29408
76A:A:L394 4.13408
77B:B:L14 5.50254168
78B:B:R22 6.86446
79B:B:T34 4.1175405
80B:B:V40 2.794503
81B:B:L51 8.06429
82B:B:H54 7.34143729
83B:B:K57 10.35419
84B:B:Y59 8.025418
85B:B:M61 3.9525426
86B:B:W63 6.26667627
87B:B:L70 6.6525425
88B:B:V71 3.575408
89B:B:Q75 8.54419
90B:B:D76 6.38629
91B:B:L79 4.978587
92B:B:I80 8428
93B:B:I81 4.596587
94B:B:W82 9.56729
95B:B:D83 7.93754158
96B:B:K89 5.882529
97B:B:I93 5.3775487
98B:B:L95 5.1575488
99B:B:W99 9.87167619
100B:B:Y105 4.685606
101B:B:V112 4.695488
102B:B:C121 4.93418
103B:B:I123 3.36406
104B:B:Y124 5686
105B:B:V133 4.265484
106B:B:H142 7.944519
107B:B:Y145 6.5175818
108B:B:L146 4.765617
109B:B:C149 3.706518
110B:B:F151 6.012509
111B:B:L152 4.295403
112B:B:Q156 4.835405
113B:B:I157 5.622517
114B:B:V158 3.59405
115B:B:T159 5.89619
116B:B:S160 4.4475456
117B:B:D163 7.632519
118B:B:L168 4.3225456
119B:B:W169 8.92714718
120B:B:F180 7.842557
121B:B:H183 9.402559
122B:B:D186 5.644519
123B:B:V187 5.0875459
124B:B:M188 5.2675418
125B:B:V200 7.5825446
126B:B:S201 4.915459
127B:B:C204 6.432517
128B:B:D205 7.448559
129B:B:K209 12.38456
130B:B:L210 5.908545
131B:B:W211 9.592558
132B:B:Q220 8.19447
133B:B:F222 9.6925448
134B:B:H225 9.80833649
135B:B:D228 8.196519
136B:B:I232 6.485448
137B:B:F234 6.4505
138B:B:F235 5.515676
139B:B:P236 6.39477
140B:B:N237 7.355475
141B:B:F241 8.78546
142B:B:T243 6.6575448
143B:B:D246 6.85419
144B:B:D247 9.585449
145B:B:R251 7.94648
146B:B:F253 7.43646
147B:B:D254 4.18409
148B:B:R256 8.7275409
149B:B:D258 9.188547
150B:B:M262 5.2475404
151B:B:Y264 7.194575
152B:B:F278 7.38477
153B:B:L285 5.288576
154B:B:Y289 6.684577
155B:B:D290 6.552516
156B:B:C294 4.1075495
157B:B:N295 8.0375476
158B:B:W297 6.74578
159B:B:D298 8.01254249
160B:B:K301 6.15254245
161B:B:H311 8.61599
162B:B:R314 12.028518
163B:B:L318 3.25596
164B:B:M325 5.21429725
165B:B:T329 5.7575498
166B:B:W332 10.3157719
167B:B:D333 8.0825499
168B:B:L336 5.324527
169B:B:K337 7.6425496
170B:B:W339 10.032599
171B:B:N340 6.835429
172G:G:V16 4.45754167
173G:G:E22 5.6425449
174G:G:A23 2.355408
175G:G:R27 6.835448
176G:G:Y40 9.555476
177G:G:D48 5.278509
178G:G:L51 3.53506
179G:G:V54 4.555426
180G:G:N59 7.272529
181G:G:P60 7.535429
182G:G:F61 5.36143728
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:R34 R:R:S92 18.08743.95YesNo067
2R:R:S92 R:R:V89 18.45693.23NoNo378
3R:R:L38 R:R:V89 19.20832.98YesNo378
4R:R:F41 R:R:L38 13.02488.53YesYes377
5R:R:L99 R:R:T91 13.5432.95YesNo077
6R:R:T91 R:R:V88 14.08223.17NoNo078
7R:R:L38 R:R:V88 10.17092.98YesNo378
8R:R:L38 R:R:L42 16.75055.54YesYes378
9R:R:C448 R:R:F41 18.44846.98NoYes377
10R:R:I81 R:R:L42 17.53335.71YesYes388
11R:R:C448 R:R:S45 18.94143.44NoYes378
12R:R:N49 R:R:S45 33.3784.47YesYes098
13R:R:I81 R:R:S45 14.31534.64YesYes388
14R:R:L74 R:R:N49 33.82188.24NoYes099
15R:R:L52 R:R:L74 34.12224.15NoNo099
16R:R:G455 R:R:L52 34.2763.42NoNo089
17R:R:G455 R:R:I461 34.43235.29NoNo088
18R:R:H458 R:R:I461 34.03177.95YesNo1298
19R:R:H458 R:R:T460 95.14478.21YesNo1298
20R:R:L62 R:R:T460 95.90982.95NoNo098
21R:R:E464 R:R:L62 96.03087.95NoNo089
22R:R:E464 R:R:K59 96.151612.15NoYes087
23B:B:D312 R:R:K59 98.42175.53NoYes057
24B:B:M325 G:G:F61 18.63753.73YesYes258
25B:B:M325 G:G:P49 35.16563.35YesNo057
26G:G:D48 G:G:P49 35.06114.83YesNo097
27B:B:S279 G:G:D48 32.2438.83NoYes099
28B:B:L284 B:B:S279 32.19014.5NoNo059
29B:B:L284 B:B:V296 33.3835.96NoNo055
30B:B:L286 B:B:V296 33.18384.47NoNo075
31B:B:L286 B:B:L318 33.28284.15NoYes076
32B:B:L318 B:B:T329 1002.95YesYes968
33B:B:H311 B:B:T329 99.14478.21YesYes998
34B:B:D333 B:B:H311 98.80985.04YesYes999
35B:B:D312 B:B:D333 98.545.32NoYes059
36R:R:I133 R:R:S132 16.45563.1YesNo088
37A:A:Y391 R:R:I133 33.90964.84NoYes048
38A:A:Y391 R:R:R129 32.422421.61NoNo049
39R:R:R129 R:R:Y454 24.4018.23NoYes099
40R:R:L73 R:R:Y454 13.92744.69YesYes099
41R:R:F443 R:R:Q446 12.23364.68NoYes089
42R:R:F443 R:R:Y415 11.520811.35NoNo089
43R:R:W186 R:R:Y415 10.08696.75YesNo679
44A:A:H387 R:R:S132 10.98666.97NoNo088
45A:A:L388 R:R:I133 17.34235.71YesYes088
46A:A:H387 A:A:I383 10.60183.98NoNo088
47A:A:L388 A:A:L394 16.37744.15YesYes088
48A:A:H41 A:A:I383 10.24963.98YesNo068
49B:B:D83 B:B:R68 29.325316.68YesNo085
50B:B:R68 B:B:Y85 29.432122.64NoNo054
51B:B:Y85 G:G:P60 14.186111.13NoYes249
52B:B:M325 G:G:P60 13.9856.71YesYes259
53B:B:Y85 G:G:F61 15.3619.28NoYes248
54B:B:D76 B:B:K78 11.95345.53YesNo098
55A:A:R42 A:A:Y37 12.114619.55NoNo094
56A:A:Y37 B:B:D76 12.00873.45NoYes249
57A:A:F222 A:A:R42 12.34366.41YesNo079
58A:A:W281 B:B:W332 37.40495.62YesYes159
59A:A:W281 B:B:D290 37.702610.05YesYes156
60B:B:C271 B:B:D290 75.27663.11NoYes056
61B:B:C271 B:B:Y289 74.83095.38NoYes057
62B:B:I273 B:B:Y289 36.49849.67NoYes067
63B:B:C250 B:B:I273 36.38846.55NoNo086
64B:B:C250 B:B:L285 36.33663.17NoYes786
65B:B:L285 B:B:V276 71.09174.47YesNo066
66B:B:A231 B:B:V276 71.03283.39NoNo056
67B:B:A231 B:B:S275 71.00333.42NoNo058
68B:B:L318 B:B:S275 70.98673YesNo068
69B:B:W332 B:B:Y59 70.38565.79YesYes198
70B:B:R314 B:B:W332 37.117824.99YesYes189
71B:B:D290 B:B:R314 37.232410.72YesYes168
72B:B:W297 B:B:Y289 37.70527.72YesYes787
73B:B:W297 B:B:Y264 37.628510.61YesYes785
74B:B:L285 B:B:Y264 37.17194.69YesYes765
75A:A:D378 A:A:Y360 11.279712.64NoYes078
76B:B:M101 B:B:Y145 65.7399.58NoYes198
77B:B:M101 B:B:Y59 65.839510.78NoYes198
78A:A:W234 B:B:Y145 41.90575.79YesYes198
79A:A:R231 A:A:W234 47.58887NoYes099
80A:A:L272 A:A:R231 47.36298.5NoNo089
81A:A:F246 A:A:L272 46.91156.09NoNo098
82A:A:F246 A:A:V248 14.36665.24NoNo097
83A:A:F246 A:A:F273 32.32254.29NoYes099
84A:A:F345 A:A:V248 13.89695.24YesNo087
85A:A:F273 A:A:F345 13.92757.5YesYes098
86A:A:L289 A:A:L291 10.09165.54NoNo098
87A:A:F345 A:A:L289 10.572914.61YesNo089
88A:A:E344 A:A:F340 21.62019.33NoYes057
89A:A:E344 A:A:L270 23.05715.3NoNo056
90A:A:F345 A:A:L270 15.84899.74YesNo086
91A:A:F363 A:A:K338 10.139916.13YesYes1155
92B:B:T221 G:G:E22 15.88627.06NoYes079
93B:B:K209 B:B:T221 16.0113.51YesNo067
94B:B:H183 B:B:K209 16.53717.03YesYes596
95B:B:H183 B:B:V187 17.68595.54YesYes599
96B:B:S160 B:B:V187 20.35896.46YesYes569
97B:B:C148 B:B:S160 20.6663.44NoYes566
98B:B:C148 B:B:R150 27.87962.79NoNo066
99B:B:H62 B:B:R150 28.036320.31NoNo066
100B:B:H62 B:B:Y105 28.1933.27NoYes066
101B:B:L69 B:B:Y105 28.44145.86NoYes056
102B:B:D83 B:B:L69 28.54434.07YesNo085
103B:B:F151 B:B:I157 10.352213.82YesYes097
104B:B:H142 B:B:S161 23.748613.95YesNo199
105B:B:G162 B:B:S161 25.21083.71NoNo199
106B:B:G162 B:B:Y145 25.385810.14NoYes198
107B:B:H142 B:B:W169 12.2836.35YesYes198
108B:B:V112 B:B:Y105 10.3873.79YesYes086
109B:B:K78 B:B:P94 11.18875.02NoNo085
110B:B:I93 B:B:L79 12.09497.14YesYes877
111B:B:I123 B:B:Y111 11.83863.63YesNo064
112A:A:Y391 R:R:H458 55.193610.89NoYes049
113R:R:H450 R:R:Q446 14.771511.13YesYes399
114B:B:I93 B:B:P94 10.99963.39YesNo075
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8W8Q
Class A
SubFamily Orphan
Type A orphans
SubType GPR101
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.89
Date 2024-01-03
D.O.I. 10.1038/s41589-023-01456-6
Net Summary
Imin 2.95
Number of Linked Nodes 872
Number of Links 1097
Number of Hubs 182
Number of Links mediated by Hubs 655
Number of Communities 26
Number of Nodes involved in Communities 264
Number of Links involved in Communities 389
Path Summary
Number Of Nodes in MetaPath 115
Number Of Links MetaPath 114
Number of Shortest Paths 2220183
Length Of Smallest Path 3
Average Path Length 34.5654
Length of Longest Path 63
Minimum Path Strength 1.4
Average Path Strength 6.87911
Maximum Path Strength 22.38
Minimum Path Correlation 0.71
Average Path Correlation 0.985605
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.32558
Average % Of Corr. Nodes 38.1355
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 49.734
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ96P66
Sequence
>8W8Q_Chain_R
PISLAHGII RSTVLVIFL AASFVGNIV LALVLQRKP QLLQVTNRF 
IFNLLVTDL LQISLVAPW VVATSVPLF WPLNSHFCT ALVSLTHLF 
AFASVNTIV VVSVDRYLS IIHPLSYPS KMTQRRGYL LLYGTWIVA 
ILQSTPPLY GWGQAAFDE RNALCSMIW GASPSYTIL SVVSFIVIP 
LIVMIACYS VVFCAARRQ HALLYNRCY QCKAAKVIF IIIFSYVLS 
LGPYCFLAV LAVWVDVET QVPQWVITI IIWLFFLQC CIHPYVYGY 
MHKTIKKEI QDMLKKFF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8W8Q_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGAGESGK 
NTIVKQFSG IFETKFQVD KVNFHMFDV GAQRDERRK WIQCFNDVT 
AIIFVVASS SYNRLQAAL KLFDSIWNN KWLRDTSVI LFLNKQDLL 
AEKVLAGKS KIEDYFPEF ARYTTPEDA TPEPGEDPR VTRAKYFIR 
DEFLRISTA SGDGRHYCY PHFTCAVDT ENIRRVFND CRDIIQRMH 
LRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8W8Q_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8W8Q_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8W8QAOrphanA orphansGPR101Homo sapiens--Gs/&β;1/&γ;22.892024-01-0310.1038/s41589-023-01456-6
8W8RAOrphanA orphansGPR101Homo sapiens-AA-14chim(NtGi1-Gs)/&β;1/&γ;23.32024-01-0310.1038/s41589-023-01456-6
8W8SAOrphanA orphansGPR101Homo sapiens-AA-14-3.32024-01-0310.1038/s41589-023-01456-6




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8W8Q.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.