psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L28	R:R:P94	6.57	Yes	Yes	4	6	6
2	R:R:L28	R:R:W97	3.42	Yes	Yes	4	6	9
3	R:R:H30	R:R:T437	5.48	No	No	0	5	6
4	R:R:G31	R:R:S92	1.86	No	No	0	5	6
5	R:R:L181	R:R:R34	6.07	No	No	0	4	5
6	R:R:R34	R:R:T437	6.47	No	No	5	5	6
7	R:R:R34	R:R:W441	4	No	Yes	5	5	8
8	R:R:S35	R:R:S92	6.52	No	No	0	6	6
9	R:R:F41	R:R:V37	2.62	No	Yes	0	7	6
10	R:R:V37	R:R:W441	9.81	Yes	Yes	5	6	8
11	R:R:V37	W:W:?1	7.16	Yes	No	5	6	0
12	R:R:L38	R:R:W441	2.28	No	Yes	0	6	8
13	R:R:F444	R:R:L38	4.87	No	No	0	8	6
14	R:R:F41	R:R:L445	6.09	No	No	0	7	7
15	R:R:L42	R:R:S45	3	No	No	8	8	9
16	R:R:I81	R:R:L42	7.14	No	No	8	8	8
17	R:R:I81	R:R:S45	4.64	No	No	8	8	9
18	R:R:C448	R:R:S45	5.16	No	No	0	8	9
19	R:R:F46	R:R:I50	2.51	No	No	0	7	6
20	R:R:F46	R:R:L78	4.87	No	No	0	7	8
21	R:R:G48	R:R:V47	1.84	No	No	0	9	6
22	R:R:L74	R:R:N49	2.75	No	Yes	0	9	9
23	R:R:D77	R:R:N49	2.69	Yes	Yes	0	9	9
24	R:R:L78	R:R:N49	5.49	No	Yes	0	8	9
25	R:R:N49	R:R:P451	8.15	Yes	No	0	9	9
26	R:R:L52	R:R:L74	5.54	No	No	0	9	9
27	R:R:G455	R:R:L52	1.71	No	No	0	9	9
28	R:R:A53	R:R:L74	4.73	No	No	0	7	9
29	R:R:I465	R:R:V55	6.14	Yes	No	0	8	9
30	R:R:M468	R:R:V55	3.04	No	No	0	7	9
31	R:R:L56	R:R:N67	6.87	Yes	No	0	8	9
32	R:R:I70	R:R:L56	2.85	No	Yes	0	8	8
33	R:R:F71	R:R:L56	3.65	No	Yes	0	8	8
34	R:R:I461	R:R:L56	2.85	Yes	Yes	0	8	8
35	R:R:P60	R:R:Q57	3.16	No	No	0	8	4
36	R:R:Q57	R:R:R68	2.34	No	No	0	4	7
37	R:R:F71	R:R:Q57	3.51	No	No	0	8	4
38	R:R:M468	R:R:R58	2.48	No	No	0	7	8
39	R:R:E464	R:R:K59	13.5	No	No	0	9	7
40	R:R:Q61	R:R:Q64	5.12	No	No	0	6	8
41	R:R:L62	R:R:L63	2.77	No	Yes	0	9	8
42	R:R:E464	R:R:L62	5.3	No	No	0	9	9
43	R:R:L63	R:R:T66	4.42	Yes	No	0	8	8
44	R:R:L63	R:R:N67	5.49	Yes	No	0	8	9
45	R:R:H458	R:R:L63	3.86	No	Yes	9	9	8
46	R:R:I461	R:R:L63	2.85	Yes	Yes	9	8	8
47	R:R:F69	R:R:V65	2.62	Yes	No	0	8	7
48	R:R:Q145	R:R:V65	4.3	No	No	0	4	7
49	R:R:D128	R:R:T66	4.34	No	No	0	9	8
50	R:R:N67	R:R:R68	4.82	No	No	0	9	7
51	R:R:R68	R:R:Y149	4.12	No	No	0	7	4
52	R:R:F69	R:R:V124	7.87	Yes	No	0	8	8
53	R:R:F69	R:R:V125	2.62	Yes	No	0	8	9
54	R:R:F71	R:R:V75	3.93	No	No	0	8	7
55	R:R:N72	R:R:T121	7.31	No	No	0	9	9
56	R:R:L152	R:R:N72	6.87	No	No	0	9	9
57	R:R:N72	R:R:W156	9.04	No	No	0	9	9
58	R:R:L73	R:R:T121	2.95	Yes	No	0	9	9
59	R:R:I122	R:R:L73	2.85	No	Yes	1	8	9
60	R:R:H450	R:R:L73	5.14	Yes	Yes	1	9	9
61	R:R:L73	R:R:Y454	4.69	Yes	Yes	1	9	9
62	R:R:D77	R:R:T76	4.34	Yes	No	0	9	9
63	R:R:C447	R:R:D77	3.11	No	Yes	0	9	9
64	R:R:D77	R:R:H450	6.3	Yes	Yes	0	9	9
65	R:R:F114	R:R:L79	6.09	Yes	No	0	6	7
66	R:R:Q80	R:R:T111	2.83	No	No	0	8	9
67	R:R:F114	R:R:Q80	9.37	Yes	No	0	6	8
68	R:R:C447	R:R:Q80	3.05	No	No	0	9	8
69	R:R:C447	R:R:I81	6.55	No	No	0	9	8
70	R:R:L83	R:R:S82	6.01	No	No	0	6	5
71	R:R:T111	R:R:V84	4.76	No	No	0	9	9
72	R:R:F114	R:R:V84	2.62	Yes	No	0	6	9
73	R:R:A85	R:R:P86	1.87	No	No	0	8	9
74	R:R:L107	R:R:W87	2.28	No	No	0	7	6
75	R:R:F175	R:R:T91	2.59	No	No	0	5	7
76	R:R:P94	R:R:V93	3.53	Yes	No	4	6	6
77	R:R:L95	R:R:V93	7.45	No	No	4	6	6
78	R:R:L95	R:R:P94	4.93	No	Yes	4	6	6
79	R:R:P94	R:R:W97	4.05	Yes	Yes	4	6	9
80	R:R:F96	R:R:L99	3.65	No	Yes	6	4	7
81	R:R:F96	W:W:?2	93.7	No	Yes	6	4	0
82	R:R:A180	R:R:W97	3.89	No	Yes	0	4	9
83	R:R:F103	R:R:L99	2.44	No	Yes	6	6	7
84	R:R:F175	R:R:L99	9.74	No	Yes	0	5	7
85	R:R:L99	W:W:?2	3.33	Yes	Yes	6	7	0
86	R:R:N100	W:W:?2	19.81	No	Yes	0	8	0
87	R:R:F103	W:W:?2	14.64	No	Yes	6	6	0
88	R:R:C104	R:R:C182	7.28	No	No	0	9	9
89	R:R:H112	R:R:V108	5.54	No	No	0	8	7
90	R:R:A173	R:R:V108	3.39	No	No	0	5	7
91	R:R:M184	R:R:V108	3.04	No	No	0	7	7
92	R:R:P166	R:R:S109	3.56	No	No	0	8	8
93	R:R:F114	R:R:L110	4.87	Yes	No	0	6	6
94	R:R:F443	R:R:T111	2.59	No	No	0	8	9
95	R:R:H112	R:R:W186	2.12	No	Yes	2	8	7
96	R:R:H112	R:R:Y415	5.44	No	No	2	8	9
97	R:R:F114	R:R:L113	2.44	Yes	No	0	6	8
98	R:R:L113	R:R:S163	9.01	No	No	0	8	8
99	R:R:A115	R:R:F200	2.77	No	Yes	0	8	8
100	R:R:F116	R:R:Q162	5.86	No	Yes	0	9	8
101	R:R:F116	R:R:F200	13.93	No	Yes	0	9	8
102	R:R:A117	R:R:W156	3.89	No	No	0	9	9
103	R:R:A117	R:R:A159	1.79	No	No	0	9	9
104	R:R:Q446	R:R:S118	5.78	No	No	1	9	9
105	R:R:H450	R:R:S118	2.79	Yes	No	1	9	9
106	R:R:N120	R:R:V119	2.96	Yes	Yes	3	8	9
107	R:R:F200	R:R:V119	2.62	Yes	Yes	0	8	9
108	R:R:P204	R:R:V119	3.53	Yes	Yes	3	9	9
109	R:R:V119	R:R:Y408	2.52	Yes	No	3	9	9
110	R:R:N120	R:R:T155	2.92	Yes	No	0	8	8
111	R:R:N120	R:R:V158	2.96	Yes	No	3	8	5
112	R:R:N120	R:R:Q162	3.96	Yes	Yes	3	8	8
113	R:R:H450	R:R:I122	5.3	Yes	No	1	9	8
114	R:R:I122	R:R:Y454	8.46	No	Yes	1	8	9
115	R:R:P204	R:R:V123	3.53	Yes	No	0	9	7
116	R:R:R129	R:R:V125	2.62	No	No	1	9	9
117	R:R:V125	R:R:Y454	2.52	No	Yes	1	9	9
118	R:R:C211	R:R:V127	1.71	No	No	0	8	7
119	R:R:D128	R:R:Y139	5.75	No	Yes	10	9	8
120	R:R:D128	R:R:M143	4.16	No	No	10	9	8
121	R:R:R129	R:R:Y212	5.14	No	No	0	9	9
122	R:R:R129	R:R:Y454	5.14	No	Yes	1	9	9
123	R:R:I134	R:R:Y130	3.63	Yes	No	11	8	8
124	R:R:C211	R:R:Y130	5.38	No	No	0	8	8
125	R:R:V214	R:R:Y130	3.79	No	No	11	7	8
126	R:R:K142	R:R:L131	5.64	No	No	0	6	6
127	R:R:S132	R:R:Y139	7.63	No	Yes	0	8	8
128	R:R:I133	R:R:I134	2.94	No	Yes	0	8	8
129	R:R:I133	R:R:V215	6.14	No	No	0	8	9
130	R:R:H135	R:R:I134	7.95	No	Yes	0	7	8
131	R:R:I134	R:R:V214	3.07	Yes	No	11	8	7
132	R:R:K142	R:R:S138	3.06	No	No	0	6	6
133	R:R:P140	R:R:Y139	4.17	No	Yes	0	7	8
134	R:R:M143	R:R:Y139	9.58	No	Yes	10	8	8
135	R:R:R147	R:R:T144	2.59	No	No	0	8	9
136	R:R:L150	R:R:R146	3.64	No	No	0	4	6
137	R:R:G148	R:R:L151	3.42	No	No	0	8	8
138	R:R:G154	R:R:I157	1.76	No	No	0	5	5
139	R:R:T155	R:R:W156	2.43	No	No	0	8	9
140	R:R:Q162	R:R:V158	7.16	Yes	No	3	8	5
141	R:R:Q162	R:R:S199	5.78	Yes	No	0	8	7
142	R:R:P165	R:R:T164	3.5	Yes	No	0	9	7
143	R:R:T164	R:R:Y168	4.99	No	No	0	7	6
144	R:R:P165	R:R:P166	5.84	Yes	No	2	9	8
145	R:R:P165	R:R:W170	6.76	Yes	Yes	2	9	6
146	R:R:P165	R:R:Y192	4.17	Yes	Yes	2	9	8
147	R:R:P166	R:R:Y192	8.34	No	Yes	2	8	8
148	R:R:L167	R:R:Y168	3.52	No	No	0	8	6
149	R:R:S189	R:R:W170	2.47	No	Yes	0	6	6
150	R:R:S191	R:R:W170	6.18	No	Yes	0	6	6
151	R:R:W170	R:R:Y192	2.89	Yes	Yes	2	6	8
152	R:R:L195	R:R:W170	2.28	No	Yes	0	6	6
153	R:R:G171	R:R:M184	1.75	No	No	0	7	7
154	R:R:G171	R:R:S189	3.71	No	No	0	7	6
155	R:R:I185	R:R:Q172	4.12	No	No	0	7	6
156	R:R:A188	R:R:Q172	3.03	No	No	0	5	6
157	R:R:C182	R:R:F175	6.98	No	No	0	9	5
158	R:R:D176	R:R:N179	5.39	No	Yes	0	5	4
159	R:R:N179	R:R:R178	9.64	Yes	No	12	4	3
160	R:R:Q433	R:R:R178	14.02	No	No	12	4	3
161	R:R:N179	R:R:Q433	9.24	Yes	No	12	4	4
162	R:R:I436	R:R:N179	7.08	No	Yes	0	5	4
163	R:R:I440	R:R:L181	2.85	No	No	0	8	4
164	R:R:M184	R:R:Y192	3.59	No	Yes	0	7	8
165	R:R:W186	R:R:Y192	1.93	Yes	Yes	2	7	8
166	R:R:T193	R:R:W186	12.13	No	Yes	0	8	7
167	R:R:S196	R:R:W186	4.94	No	Yes	0	8	7
168	R:R:W186	R:R:Y415	5.79	Yes	No	2	7	9
169	R:R:A419	R:R:W186	10.37	No	Yes	0	8	7
170	R:R:P190	R:R:S189	1.78	No	No	0	5	6
171	R:R:F200	R:R:S196	2.64	Yes	No	0	8	8
172	R:R:C416	R:R:V197	1.71	No	No	0	8	8
173	R:R:V197	R:R:V420	4.81	No	No	0	8	7
174	R:R:F200	R:R:L412	4.87	Yes	No	0	8	9
175	R:R:C416	R:R:F200	4.19	No	Yes	0	8	8
176	R:R:G413	R:R:I201	1.76	No	No	0	7	8
177	R:R:C416	R:R:I201	4.91	No	No	0	8	8
178	R:R:I203	R:R:P204	3.39	No	Yes	0	6	9
179	R:R:P204	R:R:Y408	4.17	Yes	No	3	9	9
180	R:R:L205	R:R:V409	2.98	Yes	No	0	7	7
181	R:R:C211	R:R:V207	1.71	No	No	0	8	7
182	R:R:I405	R:R:M208	2.92	No	No	0	8	9
183	R:R:M208	R:R:Y408	2.39	No	No	0	9	9
184	R:R:I401	R:R:Y212	6.04	No	No	0	9	9
185	R:R:I404	R:R:Y212	3.63	No	No	0	9	9
186	R:R:S213	R:R:V214	3.23	No	No	0	4	7
187	R:R:F216	R:R:R220	3.21	No	No	0	7	7
188	R:R:F216	R:R:I401	2.51	No	No	0	7	9
189	R:R:A219	R:R:A397	1.79	No	No	0	8	8
190	R:R:L225	R:R:R221	4.86	No	No	0	5	5
191	R:R:H223	R:R:Y227	9.8	No	No	0	6	4
192	R:R:L226	R:R:Y227	2.34	No	No	0	5	4
193	R:R:A398	R:R:C395	1.81	No	No	0	8	7
194	R:R:I403	R:R:K399	4.36	No	No	0	8	6
195	R:R:F402	R:R:F406	4.29	No	No	0	7	8
196	R:R:I403	R:R:M457	2.92	No	No	0	8	9
197	R:R:F406	R:R:L410	2.44	No	No	0	8	5
198	R:R:I449	R:R:S407	3.1	No	No	0	7	7
199	R:R:L410	R:R:L442	2.77	No	No	0	5	9
200	R:R:Q446	R:R:S411	2.89	No	No	0	9	9
201	R:R:G413	R:R:P414	4.06	No	No	0	7	9
202	R:R:I439	R:R:P414	3.39	No	No	0	7	9
203	R:R:L442	R:R:P414	3.28	No	No	0	9	9
204	R:R:F443	R:R:Y415	12.38	No	No	0	8	9
205	R:R:L418	R:R:V427	4.47	No	No	0	6	4
206	R:R:I439	R:R:L418	5.71	No	No	0	7	6
207	R:R:L421	R:R:V425	2.98	No	No	0	7	8
208	R:R:V423	R:R:W424	19.61	No	No	0	8	7
209	R:R:V427	R:R:V431	4.81	No	Yes	0	4	6
210	R:R:P432	R:R:V431	3.53	No	Yes	7	7	6
211	R:R:V431	R:R:V435	3.21	Yes	No	7	6	5
212	R:R:P432	R:R:W434	9.46	No	No	7	7	4
213	R:R:P432	R:R:V435	5.3	No	No	7	7	5
214	R:R:V435	R:R:W434	8.58	No	No	7	5	4
215	R:R:I438	R:R:W434	2.35	No	No	0	6	4
216	R:R:T437	R:R:W441	4.85	No	Yes	5	6	8
217	R:R:I438	R:R:L442	2.85	No	No	0	6	9
218	R:R:W441	W:W:?1	21.91	Yes	No	5	8	0
219	R:R:I449	R:R:L445	2.85	No	No	0	7	7
220	R:R:H450	R:R:Q446	11.13	Yes	No	1	9	9
221	R:R:Y452	R:R:Y456	7.94	No	Yes	0	7	7
222	R:R:V453	R:R:Y454	10.09	No	Yes	0	9	9
223	R:R:G455	R:R:I461	1.76	No	Yes	0	9	8
224	R:R:K462	R:R:Y456	4.78	No	Yes	14	9	7
225	R:R:I465	R:R:Y456	2.42	Yes	Yes	0	8	7
226	R:R:Q466	R:R:Y456	4.51	No	Yes	14	7	7
227	R:R:H458	R:R:T460	9.58	No	No	0	9	8
228	R:R:H458	R:R:I461	5.3	No	Yes	9	9	8
229	R:R:I461	R:R:I465	2.94	Yes	Yes	0	8	8
230	R:R:K462	R:R:Q466	5.42	No	No	14	9	7
231	R:R:D467	R:R:K463	4.15	No	No	0	6	6
232	R:R:F473	R:R:L469	2.44	No	No	0	4	8
233	R:R:F472	R:R:F473	13.93	No	No	0	2	4
234	R:R:A173	R:R:T105	1.68	No	No	0	5	7
235	R:R:G171	R:R:Q172	1.64	No	No	0	7	6
236	R:R:S138	R:R:S141	1.63	No	No	0	6	5
237	R:R:S126	R:R:V127	1.62	No	No	0	9	7
238	R:R:S126	R:R:V207	1.62	No	No	0	9	7
239	R:R:A218	R:R:I134	1.62	No	Yes	0	7	8
240	R:R:S407	R:R:V453	1.62	No	No	0	7	9
241	R:R:V39	R:R:V89	1.6	No	No	0	5	7
242	R:R:V47	R:R:V51	1.6	No	No	0	6	8
243	R:R:G31	R:R:H30	1.59	No	No	0	5	5
244	R:R:A85	R:R:L42	1.58	No	No	0	8	8
245	R:R:I133	R:R:S132	1.55	No	No	0	8	8
246	R:R:I33	R:R:V37	1.54	No	Yes	0	4	6
247	R:R:I465	R:R:V51	1.54	Yes	No	0	8	8
248	R:R:I203	R:R:V198	1.54	No	No	0	6	6
249	R:R:I206	R:R:V202	1.54	No	No	0	4	6
250	R:R:I404	R:R:V400	1.54	No	No	0	9	9
251	R:R:I436	R:R:V431	1.54	No	Yes	0	5	6
252	R:R:I32	R:R:T36	1.52	No	No	0	6	5
253	R:R:I160	R:R:T164	1.52	No	No	0	5	7
254	R:R:M457	R:R:V400	1.52	No	No	0	9	9
255	R:R:F69	R:R:G148	1.51	Yes	No	0	8	8
256	R:R:L28	R:R:S92	1.5	Yes	No	0	6	6
257	R:R:L38	R:R:V88	1.49	No	No	0	6	8
258	R:R:L107	R:R:V84	1.49	No	No	0	7	9
259	R:R:L421	R:R:V427	1.49	No	No	0	7	4
260	R:R:I209	R:R:I405	1.47	No	No	13	7	8
261	R:R:G154	R:R:Y153	1.45	No	No	0	5	6
262	R:R:G169	R:R:Y168	1.45	No	No	0	7	6
263	R:R:I32	R:R:L28	1.43	No	Yes	0	6	6
264	R:R:I50	R:R:L54	1.43	No	No	0	6	5
265	R:R:Q64	R:R:V65	1.43	No	No	0	8	7
266	R:R:I157	R:R:L161	1.43	No	No	0	5	6
267	R:R:I201	R:R:L205	1.43	No	Yes	0	8	7
268	R:R:I209	R:R:L205	1.43	No	Yes	13	7	7
269	R:R:I405	R:R:L205	1.43	No	Yes	13	8	7
270	R:R:I465	R:R:L469	1.43	Yes	No	0	8	8
271	R:R:P98	R:R:W97	1.35	No	Yes	0	4	9
272	R:R:H135	R:R:L131	1.29	No	No	0	7	6
273	R:R:R146	R:R:T144	1.29	No	No	0	6	9
274	R:R:V425	R:R:W424	1.23	No	No	0	8	7
275	R:R:F114	R:R:L83	1.22	Yes	No	0	6	6
276	R:R:F103	R:R:W87	1	No	No	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L28	3.23	4	4	6
2	R:R:V37	5.2825	4	5	6
3	R:R:N49	4.77	4	0	9
4	R:R:L56	4.055	4	0	8
5	R:R:L63	3.878	5	9	8
6	R:R:F69	3.655	4	0	8
7	R:R:L73	3.9075	4	1	9
8	R:R:D77	4.11	4	0	9
9	R:R:P94	4.77	4	4	6
10	R:R:W97	3.1775	4	4	9
11	R:R:L99	4.79	4	6	7
12	R:R:F114	4.435	6	0	6
13	R:R:V119	2.9075	4	3	9
14	R:R:N120	3.2	4	3	8
15	R:R:I134	3.842	5	11	8
16	R:R:Y139	6.7825	4	10	8
17	R:R:Q162	5.69	4	3	8
18	R:R:P165	5.0675	4	2	9
19	R:R:W170	4.116	5	2	6
20	R:R:N179	7.8375	4	12	4
21	R:R:W186	6.21333	6	2	7
22	R:R:Y192	4.184	5	2	8
23	R:R:F200	5.17	6	0	8
24	R:R:P204	3.655	4	3	9
25	R:R:L205	1.8175	4	13	7
26	R:R:V431	3.2725	4	7	6
27	R:R:W441	8.57	5	5	8
28	R:R:H450	6.132	5	1	9
29	R:R:Y454	6.18	5	1	9
30	R:R:Y456	4.9125	4	14	7
31	R:R:I461	3.14	5	9	8
32	R:R:I465	2.894	5	0	8
33	W:W:?2	32.87	4	6	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G31	R:R:H30	28.3691	1.59	No	No	0	5	5
2	R:R:G31	R:R:S92	26.0714	1.86	No	No	0	5	6
3	R:R:L28	R:R:S92	21.4394	1.5	Yes	No	0	6	6
4	R:R:H30	R:R:T437	30.6547	5.48	No	No	0	5	6
5	R:R:T437	R:R:W441	32.6728	4.85	No	Yes	5	6	8
6	R:R:F41	R:R:V37	54.6593	2.62	No	Yes	0	7	6
7	R:R:V37	R:R:W441	48.2281	9.81	Yes	Yes	5	6	8
8	R:R:F41	R:R:L445	56.799	6.09	No	No	0	7	7
9	R:R:I449	R:R:L445	58.9265	2.85	No	No	0	7	7
10	R:R:I449	R:R:S407	61.0419	3.1	No	No	0	7	7
11	R:R:S407	R:R:V453	63.1086	1.62	No	No	0	7	9
12	R:R:V453	R:R:Y454	65.1997	10.09	No	Yes	0	9	9
13	R:R:L73	R:R:Y454	60.2152	4.69	Yes	Yes	1	9	9
14	R:R:H450	R:R:L73	56.0209	5.14	Yes	Yes	1	9	9
15	R:R:D77	R:R:H450	100	6.3	Yes	Yes	0	9	9
16	R:R:C447	R:R:D77	94.0186	3.11	No	Yes	0	9	9
17	R:R:C447	R:R:I81	10.8626	6.55	No	No	0	9	8
18	R:R:I122	R:R:Y454	43.6144	8.46	No	Yes	1	8	9
19	R:R:H450	R:R:I122	44.2405	5.3	Yes	No	1	9	8
20	R:R:D77	R:R:N49	94.3468	2.69	Yes	Yes	0	9	9
21	R:R:I461	R:R:I465	24.5335	2.94	Yes	Yes	0	8	8
22	R:R:G455	R:R:I461	83.3445	1.76	No	Yes	0	9	8
23	R:R:G455	R:R:L52	84.4994	1.71	No	No	0	9	9
24	R:R:L52	R:R:L74	85.6422	5.54	No	No	0	9	9
25	R:R:L74	R:R:N49	87.8913	2.75	No	Yes	0	9	9
26	R:R:I461	R:R:L56	14.8745	2.85	Yes	Yes	0	8	8
27	R:R:I461	R:R:L63	47.8086	2.85	Yes	Yes	9	8	8
28	R:R:V125	R:R:Y454	20.5276	2.52	No	Yes	1	9	9
29	R:R:F69	R:R:V125	18.7283	2.62	Yes	No	0	8	9
30	R:R:L63	R:R:T66	38.7089	4.42	Yes	No	0	8	8
31	R:R:D128	R:R:T66	37.1163	4.34	No	No	0	9	8
32	R:R:L73	R:R:T121	29.0378	2.95	Yes	No	0	9	9
33	R:R:N72	R:R:T121	28.4907	7.31	No	No	0	9	9
34	R:R:N72	R:R:W156	27.433	9.04	No	No	0	9	9
35	R:R:F114	R:R:Q80	26.0592	9.37	Yes	No	0	6	8
36	R:R:C447	R:R:Q80	91.0826	3.05	No	No	0	9	8
37	R:R:Q80	R:R:T111	71.6552	2.83	No	No	0	8	9
38	R:R:T111	R:R:V84	24.7158	4.76	No	No	0	9	9
39	R:R:F114	R:R:V84	18.6493	2.62	Yes	No	0	6	9
40	R:R:L107	R:R:V84	33.5663	1.49	No	No	0	7	9
41	R:R:L107	R:R:W87	31.0863	2.28	No	No	0	7	6
42	R:R:F175	R:R:L99	11.4461	9.74	No	Yes	0	5	7
43	R:R:F103	R:R:L99	17.0263	2.44	No	Yes	6	6	7
44	R:R:F103	R:R:W87	28.3205	1	No	No	0	6	6
45	R:R:H112	R:R:Y415	11.1543	5.44	No	No	2	8	9
46	R:R:F443	R:R:Y415	65.6617	12.38	No	No	0	8	9
47	R:R:F443	R:R:T111	66.4215	2.59	No	No	0	8	9
48	R:R:H112	R:R:V108	10.9598	5.54	No	No	0	8	7
49	R:R:W186	R:R:Y415	53.7232	5.79	Yes	No	2	7	9
50	R:R:W186	R:R:Y192	31.147	1.93	Yes	Yes	2	7	8
51	R:R:F200	R:R:V119	19.0627	2.62	Yes	Yes	0	8	9
52	R:R:N120	R:R:V119	22.7585	2.96	Yes	Yes	3	8	9
53	R:R:N120	R:R:T155	25.4696	2.92	Yes	No	0	8	8
54	R:R:T155	R:R:W156	25.7917	2.43	No	No	0	8	9
55	R:R:R129	R:R:Y454	22.7342	5.14	No	Yes	1	9	9
56	R:R:I134	R:R:Y130	10.7896	3.63	Yes	No	11	8	8
57	R:R:I133	R:R:I134	26.0167	2.94	No	Yes	0	8	8
58	R:R:I133	R:R:S132	29.1836	1.55	No	No	0	8	8
59	R:R:S132	R:R:Y139	30.8188	7.63	No	Yes	0	8	8
60	R:R:D128	R:R:Y139	33.9311	5.75	No	Yes	10	9	8
61	R:R:R129	R:R:Y212	21.0625	5.14	No	No	0	9	9
62	R:R:P165	R:R:Y192	10.1696	4.17	Yes	Yes	2	9	8
63	R:R:G171	R:R:M184	12.0418	1.75	No	No	0	7	7
64	R:R:L418	R:R:V427	15.0386	4.47	No	No	0	6	4
65	R:R:I439	R:R:L418	16.3334	5.71	No	No	0	7	6
66	R:R:I439	R:R:P414	17.6342	3.39	No	No	0	7	9
67	R:R:G413	R:R:P414	29.4572	4.06	No	No	0	7	9
68	R:R:G413	R:R:I201	30.6608	1.76	No	No	0	7	8
69	R:R:C416	R:R:I201	34.8246	4.91	No	No	0	8	8
70	R:R:C416	R:R:F200	38.1436	4.19	No	Yes	0	8	8
71	R:R:F200	R:R:S196	34.4113	2.64	Yes	No	0	8	8
72	R:R:I404	R:R:Y212	11.8412	3.63	No	No	0	9	9
73	R:R:L442	R:R:P414	10.9781	3.28	No	No	0	9	9
74	R:R:S196	R:R:W186	34.5876	4.94	No	Yes	0	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:R34	R:R:T437	6.47	5	No	No	5	6	2	2
R:R:R34	R:R:W441	4	5	No	Yes	5	8	2	1
R:R:F41	R:R:V37	2.62	0	No	Yes	7	6	2	1
R:R:V37	R:R:W441	9.81	5	Yes	Yes	6	8	1	1
R:R:V37	W:W:?1	7.16	5	Yes	No	6	0	1	0
R:R:L38	R:R:W441	2.28	0	No	Yes	6	8	2	1
R:R:T437	R:R:W441	4.85	5	No	Yes	6	8	2	1
R:R:W441	W:W:?1	21.91	5	Yes	No	8	0	1	0
R:R:I33	R:R:V37	1.54	0	No	Yes	4	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F96	R:R:L99	3.65	6	No	Yes	4	7	1	1
R:R:F96	W:W:?2	93.7	6	No	Yes	4	0	1	0
R:R:F103	R:R:L99	2.44	6	No	Yes	6	7	1	1
R:R:F175	R:R:L99	9.74	0	No	Yes	5	7	2	1
R:R:L99	W:W:?2	3.33	6	Yes	Yes	7	0	1	0
R:R:N100	W:W:?2	19.81	0	No	Yes	8	0	1	0
R:R:F103	W:W:?2	14.64	6	No	Yes	6	0	1	0
R:R:F103	R:R:W87	1	6	No	No	6	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8W8R_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.71
Number of Linked Nodes	252
Number of Links	276
Number of Hubs	33
Number of Links mediated by Hubs	126
Number of Communities	14
Number of Nodes involved in Communities	60
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	37542
Length Of Smallest Path	3
Average Path Length	16.0275
Length of Longest Path	37
Minimum Path Strength	1.43
Average Path Strength	4.33074
Maximum Path Strength	56.755
Minimum Path Correlation	0.7
Average Path Correlation	0.927198
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	47.0796
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.092
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • D1 dopamine receptor binding • molecular function activator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase activator activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • establishment of protein localization • nitrogen compound transport • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • regulation of hormone secretion • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • receptor complex • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	U7D
PDB Residues	W:W:?1 W:W:?2
Environment Details	Open EMBL-EBI Page
Code	U7D
Name	1-(4-methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea
Synonyms	CHEMBL2134995
Identifier
Formula	C14 H12 F3 N3 S
Molecular Weight	311.325
SMILES
PubChem	848971
Formal Charge	0
Total Atoms	33
Total Chiral Atoms	0
Total Bonds	34
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96P66
Sequence	>8W8R_nogp_Chain_R L A H G I I R S T V L V I F L A A S F V G N I V L A L V L Q R K P Q L L Q V T N R F I F N L L V T D L L Q I S L V A P W V V A T S V P L F W P L N S H F C T A L V S L T H L F A F A S V N T I V V V S V D R Y L S I I H P L S Y P S K M T Q R R G Y L L L Y G T W I V A I L Q S T P P L Y G W G Q A A F D E R N A L C S M I W G A S P S Y T I L S V V S F I V I P L I V M I A C Y S V V F C A A R R Q H A L L Y N C K A A K V I F I I I F S Y V L S L G P Y C F L A V L A V W V D V E T Q V P Q W V I T I I I W L F F L Q C C I H P Y V Y G Y M H K T I K K E I Q D M L K K F F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8W8S	A	Orphan	Orphan	GPR101	Homo sapiens	-	AA-14	-	3.3	2024-01-03	10.1038/s41589-023-01456-6
	8W8R	A	Orphan	Orphan	GPR101	Homo sapiens	-	AA-14	chim(NtGi1-Gs)/β1/γ2	3.3	2024-01-03	10.1038/s41589-023-01456-6
	8W8R (No Gprot)	A	Orphan	Orphan	GPR101	Homo sapiens	-	AA-14		3.3	2024-01-03	10.1038/s41589-023-01456-6
	8W8Q	A	Orphan	Orphan	GPR101	Homo sapiens	-	-	Gs/β1/γ2	2.89	2024-01-03	10.1038/s41589-023-01456-6
	8W8Q (No Gprot)	A	Orphan	Orphan	GPR101	Homo sapiens	-	-		2.89	2024-01-03	10.1038/s41589-023-01456-6

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