psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E177	R:R:P25	6.29	No	No	0	4	7
2	R:R:H30	R:R:I26	7.95	No	No	0	5	6
3	R:R:I26	R:R:R34	3.76	No	Yes	0	6	5
4	R:R:I26	R:R:W97	3.52	No	Yes	0	6	9
5	R:R:I32	R:R:L28	4.28	No	No	0	6	6
6	R:R:L28	R:R:P94	3.28	No	No	0	6	6
7	R:R:H30	R:R:T437	8.21	No	No	0	5	6
8	R:R:G31	R:R:R34	3	No	Yes	0	5	5
9	R:R:I33	R:R:T36	3.04	No	No	0	4	5
10	R:R:R34	R:R:S92	3.95	Yes	No	0	5	6
11	R:R:L181	R:R:R34	3.64	No	Yes	0	4	5
12	R:R:R34	R:R:T437	11.64	Yes	No	0	5	6
13	R:R:S35	R:R:V89	8.08	No	No	1	6	7
14	R:R:S35	R:R:S92	3.26	No	No	1	6	6
15	R:R:V37	R:R:W441	9.81	No	No	0	6	8
16	R:R:F41	R:R:L38	8.53	Yes	Yes	1	7	6
17	R:R:L38	R:R:L42	5.54	Yes	Yes	1	6	8
18	R:R:L38	R:R:V88	2.98	Yes	No	1	6	8
19	R:R:L38	R:R:V89	2.98	Yes	No	1	6	7
20	R:R:F444	R:R:L38	3.65	No	Yes	1	8	6
21	R:R:F41	R:R:L42	14.61	Yes	Yes	1	7	8
22	R:R:F41	R:R:F444	3.22	Yes	No	1	7	8
23	R:R:F41	R:R:L445	4.87	Yes	No	1	7	7
24	R:R:C448	R:R:F41	6.98	No	Yes	1	8	7
25	R:R:I81	R:R:L42	5.71	Yes	Yes	1	8	8
26	R:R:N49	R:R:S45	4.47	Yes	Yes	0	9	9
27	R:R:I81	R:R:S45	4.64	Yes	Yes	1	8	9
28	R:R:C447	R:R:S45	3.44	Yes	Yes	1	9	9
29	R:R:C448	R:R:S45	3.44	No	Yes	1	8	9
30	R:R:F46	R:R:I50	3.77	No	No	0	7	6
31	R:R:F46	R:R:L78	8.53	No	No	0	7	8
32	R:R:F46	R:R:I81	6.28	No	Yes	0	7	8
33	R:R:L74	R:R:N49	8.24	No	Yes	0	9	9
34	R:R:D77	R:R:N49	5.39	Yes	Yes	0	9	9
35	R:R:N49	R:R:P451	9.77	Yes	No	0	9	9
36	R:R:L52	R:R:L74	4.15	No	No	0	9	9
37	R:R:G455	R:R:L52	3.42	No	No	0	9	9
38	R:R:A53	R:R:L74	4.73	No	No	0	7	9
39	R:R:I465	R:R:V55	6.14	No	No	0	8	9
40	R:R:M468	R:R:V55	4.56	Yes	No	0	7	9
41	R:R:L56	R:R:N67	5.49	No	No	0	8	9
42	R:R:F71	R:R:L56	7.31	No	No	0	8	8
43	R:R:F71	R:R:Q57	8.2	No	No	0	8	4
44	R:R:K59	R:R:R58	4.95	No	No	0	7	8
45	R:R:M468	R:R:R58	3.72	Yes	No	0	7	8
46	R:R:E464	R:R:K59	12.15	No	No	0	9	7
47	R:R:E464	R:R:L62	7.95	No	No	0	9	9
48	R:R:L63	R:R:T66	8.84	Yes	No	0	8	8
49	R:R:L63	R:R:N67	9.61	Yes	No	0	8	9
50	R:R:H458	R:R:L63	9	No	Yes	5	9	8
51	R:R:I461	R:R:L63	4.28	No	Yes	5	8	8
52	R:R:M143	R:R:V65	4.56	No	No	0	8	7
53	R:R:D128	R:R:T66	5.78	No	No	0	9	8
54	R:R:R68	R:R:Y149	5.14	No	No	0	7	4
55	R:R:F69	R:R:V124	7.87	Yes	No	6	8	8
56	R:R:D128	R:R:F69	7.17	No	Yes	0	9	8
57	R:R:F69	R:R:G148	3.01	Yes	No	0	8	8
58	R:R:F69	R:R:L151	4.87	Yes	No	6	8	8
59	R:R:I70	R:R:V125	3.07	No	No	0	8	9
60	R:R:F71	R:R:V75	3.93	No	No	0	8	7
61	R:R:N72	R:R:T121	8.77	No	No	0	9	9
62	R:R:L152	R:R:N72	5.49	No	No	0	9	9
63	R:R:N72	R:R:W156	9.04	No	Yes	0	9	9
64	R:R:L73	R:R:S118	3	Yes	Yes	1	9	9
65	R:R:L73	R:R:T121	5.9	Yes	No	0	9	9
66	R:R:H450	R:R:L73	11.57	Yes	Yes	1	9	9
67	R:R:L73	R:R:Y454	4.69	Yes	Yes	0	9	9
68	R:R:A117	R:R:T76	5.03	No	No	1	9	9
69	R:R:S118	R:R:T76	4.8	Yes	No	1	9	9
70	R:R:T76	R:R:W156	6.06	No	Yes	1	9	9
71	R:R:D77	R:R:S118	5.89	Yes	Yes	1	9	9
72	R:R:C447	R:R:D77	9.34	Yes	Yes	1	9	9
73	R:R:D77	R:R:H450	12.61	Yes	Yes	1	9	9
74	R:R:L79	R:R:S82	3	No	No	0	7	5
75	R:R:F114	R:R:L79	7.31	Yes	No	0	6	7
76	R:R:F114	R:R:Q80	12.88	Yes	No	0	6	8
77	R:R:Q446	R:R:Q80	3.84	Yes	No	0	9	8
78	R:R:C447	R:R:Q80	3.05	Yes	No	0	9	8
79	R:R:C447	R:R:I81	3.27	Yes	Yes	1	9	8
80	R:R:F114	R:R:L83	4.87	Yes	No	0	6	6
81	R:R:L107	R:R:V84	4.47	No	No	0	7	9
82	R:R:T111	R:R:V84	12.69	No	No	0	9	9
83	R:R:F103	R:R:W87	9.02	No	No	0	6	6
84	R:R:L107	R:R:W87	5.69	No	No	0	7	6
85	R:R:T91	R:R:V88	3.17	No	No	0	7	8
86	R:R:F444	R:R:V88	5.24	No	No	1	8	8
87	R:R:S92	R:R:V89	3.23	No	No	1	6	7
88	R:R:P94	R:R:V93	3.53	No	No	0	6	6
89	R:R:P94	R:R:W97	8.11	No	Yes	0	6	9
90	R:R:F96	R:R:L95	12.18	No	No	0	4	6
91	R:R:F175	R:R:W97	4.01	No	Yes	0	5	9
92	R:R:E177	R:R:W97	3.27	No	Yes	0	4	9
93	R:R:F103	R:R:L99	9.74	No	No	0	6	7
94	R:R:F175	R:R:L99	8.53	No	No	0	5	7
95	R:R:H102	R:R:N100	3.83	No	No	0	5	8
96	R:R:F103	R:R:N100	3.62	No	No	0	6	8
97	R:R:C104	R:R:F175	4.19	No	No	0	9	5
98	R:R:C104	R:R:C182	7.28	No	No	0	9	9
99	R:R:C182	R:R:L107	3.17	No	No	0	9	7
100	R:R:H112	R:R:V108	5.54	Yes	No	2	8	7
101	R:R:A173	R:R:V108	5.09	No	No	2	5	7
102	R:R:M184	R:R:V108	3.04	Yes	No	2	7	7
103	R:R:L167	R:R:S109	9.01	No	No	0	8	8
104	R:R:F114	R:R:L110	3.65	Yes	No	0	6	6
105	R:R:F116	R:R:H112	3.39	Yes	Yes	2	9	8
106	R:R:H112	R:R:W186	5.29	Yes	Yes	2	8	7
107	R:R:H112	R:R:Y415	8.71	Yes	No	2	8	9
108	R:R:F114	R:R:L113	3.65	Yes	Yes	0	6	8
109	R:R:L113	R:R:W156	4.56	Yes	Yes	0	8	9
110	R:R:I160	R:R:L113	5.71	No	Yes	0	5	8
111	R:R:L113	R:R:S163	3	Yes	No	0	8	8
112	R:R:F116	R:R:Q162	22.25	Yes	No	2	9	8
113	R:R:F116	R:R:S199	3.96	Yes	No	2	9	7
114	R:R:F116	R:R:F200	22.51	Yes	Yes	0	9	8
115	R:R:A117	R:R:W156	7.78	No	Yes	1	9	9
116	R:R:H450	R:R:S118	5.58	Yes	Yes	1	9	9
117	R:R:P204	R:R:V119	3.53	Yes	No	1	9	9
118	R:R:V119	R:R:Y408	6.31	No	Yes	1	9	9
119	R:R:N120	R:R:V158	5.91	No	No	0	8	5
120	R:R:H450	R:R:I122	7.95	Yes	No	0	9	8
121	R:R:I122	R:R:Y454	10.88	No	Yes	0	8	9
122	R:R:P204	R:R:V123	3.53	Yes	No	0	9	7
123	R:R:L151	R:R:V124	2.98	No	No	6	8	8
124	R:R:V125	R:R:Y454	3.79	No	Yes	0	9	9
125	R:R:M208	R:R:S126	6.13	No	No	1	9	9
126	R:R:S126	R:R:Y212	3.82	No	Yes	1	9	9
127	R:R:D128	R:R:Y139	10.34	No	Yes	0	9	8
128	R:R:R129	R:R:Y212	7.2	No	Yes	0	9	9
129	R:R:R129	R:R:Y454	8.23	No	Yes	0	9	9
130	R:R:I134	R:R:Y130	9.67	Yes	Yes	3	8	8
131	R:R:H135	R:R:Y130	7.62	Yes	Yes	3	7	8
132	R:R:C211	R:R:Y130	6.72	No	Yes	0	8	8
133	R:R:V214	R:R:Y130	3.79	No	Yes	3	7	8
134	R:R:K142	R:R:L131	5.64	No	No	0	6	6
135	R:R:I133	R:R:S132	3.1	No	No	0	8	8
136	R:R:S132	R:R:Y139	7.63	No	Yes	0	8	8
137	R:R:I133	R:R:V215	6.14	No	No	0	8	9
138	R:R:H135	R:R:I134	10.61	Yes	Yes	3	7	8
139	R:R:I134	R:R:V214	4.61	Yes	No	3	8	7
140	R:R:K142	R:R:S138	4.59	No	No	0	6	6
141	R:R:P140	R:R:Y139	4.17	No	Yes	0	7	8
142	R:R:M143	R:R:Y139	5.99	No	Yes	0	8	8
143	R:R:Q145	R:R:Y149	11.27	No	No	0	4	4
144	R:R:Y149	R:R:Y153	2.98	No	No	0	4	6
145	R:R:Q162	R:R:V158	5.73	No	No	0	8	5
146	R:R:Q162	R:R:S199	7.22	No	No	2	8	7
147	R:R:P165	R:R:T164	5.25	Yes	No	2	9	7
148	R:R:T164	R:R:Y168	3.75	No	No	2	7	6
149	R:R:P165	R:R:P166	5.84	Yes	Yes	2	9	8
150	R:R:P165	R:R:Y168	11.13	Yes	No	2	9	6
151	R:R:P165	R:R:W170	9.46	Yes	Yes	2	9	6
152	R:R:P165	R:R:Y192	9.74	Yes	Yes	2	9	8
153	R:R:P166	R:R:Y192	9.74	Yes	Yes	2	8	8
154	R:R:W170	R:R:Y168	5.79	Yes	No	2	6	6
155	R:R:S189	R:R:W170	4.94	No	Yes	0	6	6
156	R:R:S191	R:R:W170	3.71	No	Yes	0	6	6
157	R:R:W170	R:R:Y192	5.79	Yes	Yes	2	6	8
158	R:R:A188	R:R:Q172	7.58	No	No	0	5	6
159	R:R:A173	R:R:M184	3.22	No	Yes	2	5	7
160	R:R:D176	R:R:N179	12.12	No	No	0	5	4
161	R:R:D176	R:R:L181	4.07	No	No	0	5	4
162	R:R:E428	R:R:R178	13.96	No	No	0	4	3
163	R:R:Q433	R:R:R178	15.19	No	No	0	4	3
164	R:R:E428	R:R:N179	5.26	No	No	0	4	4
165	R:R:I436	R:R:N179	9.91	No	No	0	5	4
166	R:R:M184	R:R:W186	18.61	Yes	Yes	2	7	7
167	R:R:M184	R:R:Y192	3.59	Yes	Yes	2	7	8
168	R:R:A188	R:R:I185	3.25	No	No	0	5	7
169	R:R:T193	R:R:W186	12.13	No	Yes	0	8	7
170	R:R:S196	R:R:W186	4.94	No	Yes	0	8	7
171	R:R:W186	R:R:Y415	6.75	Yes	No	2	7	9
172	R:R:A419	R:R:W186	11.67	No	Yes	0	8	7
173	R:R:A422	R:R:W186	3.89	No	Yes	0	5	7
174	R:R:P190	R:R:S189	3.56	No	No	0	5	6
175	R:R:T193	R:R:V423	4.76	No	No	0	8	8
176	R:R:C416	R:R:V197	6.83	No	No	0	8	8
177	R:R:V198	R:R:V202	6.41	No	No	0	6	6
178	R:R:F200	R:R:L412	8.53	Yes	Yes	0	8	9
179	R:R:C416	R:R:F200	4.19	No	Yes	0	8	8
180	R:R:G413	R:R:I201	3.53	No	No	0	7	8
181	R:R:C416	R:R:I201	4.91	No	No	0	8	8
182	R:R:I203	R:R:P204	3.39	No	Yes	0	6	9
183	R:R:P204	R:R:Y408	6.95	Yes	Yes	1	9	9
184	R:R:L205	R:R:Y408	4.69	No	Yes	0	7	9
185	R:R:L205	R:R:V409	4.47	No	No	0	7	7
186	R:R:M208	R:R:Y212	3.59	No	Yes	1	9	9
187	R:R:M208	R:R:Y408	4.79	No	Yes	1	9	9
188	R:R:I401	R:R:Y212	7.25	No	Yes	0	9	9
189	R:R:I404	R:R:Y212	8.46	No	Yes	0	9	9
190	R:R:I405	R:R:Y212	3.63	No	Yes	0	8	9
191	R:R:F216	R:R:R220	7.48	Yes	No	0	7	7
192	R:R:F216	R:R:I401	3.77	Yes	No	0	7	9
193	R:R:Q394	R:R:R220	22.2	No	No	0	8	7
194	R:R:Q222	R:R:R221	5.84	No	No	0	8	5
195	R:R:L225	R:R:R221	3.64	No	No	0	5	5
196	R:R:H223	R:R:Y227	21.78	No	No	7	6	4
197	R:R:H223	R:R:Y393	10.89	No	Yes	7	6	7
198	R:R:H223	R:R:Q394	9.89	No	No	0	6	8
199	R:R:Y227	R:R:Y393	12.91	No	Yes	7	4	7
200	R:R:Q394	R:R:R391	9.35	No	No	0	8	4
201	R:R:K396	R:R:Y393	10.75	No	Yes	0	9	7
202	R:R:I403	R:R:K399	5.82	No	No	0	8	6
203	R:R:F402	R:R:F406	9.65	No	No	0	7	8
204	R:R:I403	R:R:M457	4.37	No	No	0	8	9
205	R:R:I404	R:R:V453	4.61	No	No	0	9	9
206	R:R:I449	R:R:S407	3.1	No	No	0	7	7
207	R:R:S407	R:R:V453	3.23	No	No	0	7	9
208	R:R:L412	R:R:Y408	4.69	Yes	Yes	1	9	9
209	R:R:L410	R:R:L442	4.15	No	No	0	5	9
210	R:R:L412	R:R:S411	3	Yes	No	1	9	9
211	R:R:Q446	R:R:S411	7.22	Yes	No	1	9	9
212	R:R:L412	R:R:Q446	3.99	Yes	Yes	1	9	9
213	R:R:G413	R:R:P414	4.06	No	No	0	7	9
214	R:R:I439	R:R:P414	5.08	No	No	0	7	9
215	R:R:F443	R:R:Y415	11.35	No	No	0	8	9
216	R:R:F417	R:R:L421	9.74	No	No	0	7	7
217	R:R:I436	R:R:L418	4.28	No	No	0	5	6
218	R:R:Q430	R:R:V425	5.73	No	No	0	1	8
219	R:R:D426	R:R:Q430	5.22	No	No	0	7	1
220	R:R:Q430	R:R:T429	8.5	No	No	0	1	8
221	R:R:P432	R:R:V431	3.53	No	No	4	7	6
222	R:R:V431	R:R:V435	3.21	No	No	4	6	5
223	R:R:I436	R:R:V431	3.07	No	No	0	5	6
224	R:R:P432	R:R:W434	8.11	No	No	4	7	4
225	R:R:P432	R:R:V435	7.07	No	No	4	7	5
226	R:R:V435	R:R:W434	9.81	No	No	4	5	4
227	R:R:T437	R:R:W441	8.49	No	No	0	6	8
228	R:R:I438	R:R:W441	7.05	No	No	0	6	8
229	R:R:F443	R:R:Q446	4.68	No	Yes	0	8	9
230	R:R:C448	R:R:L445	4.76	No	No	1	8	7
231	R:R:H450	R:R:Q446	11.13	Yes	Yes	1	9	9
232	R:R:H450	R:R:I449	5.3	Yes	No	0	9	7
233	R:R:Y452	R:R:Y456	10.92	No	No	0	7	7
234	R:R:M457	R:R:Y452	3.59	No	No	0	9	7
235	R:R:V453	R:R:Y454	10.09	No	Yes	0	9	9
236	R:R:G455	R:R:I461	5.29	No	No	0	9	8
237	R:R:K462	R:R:Y456	4.78	No	No	0	9	7
238	R:R:I465	R:R:Y456	3.63	No	No	0	8	7
239	R:R:H458	R:R:T460	8.21	No	No	0	9	8
240	R:R:H458	R:R:I461	7.95	No	No	5	9	8
241	R:R:K462	R:R:Q466	12.2	No	No	0	9	7
242	R:R:K463	R:R:Q466	6.78	No	No	0	6	7
243	R:R:D467	R:R:K463	5.53	No	No	0	6	6
244	R:R:F472	R:R:F473	6.43	No	No	0	2	4
245	R:R:L62	R:R:T460	2.95	No	No	0	9	8
246	R:R:I32	R:R:I33	2.94	No	No	0	6	4
247	R:R:D176	R:R:S183	2.94	No	No	0	5	4
248	R:R:N120	R:R:T155	2.92	No	No	0	8	8
249	R:R:Q145	R:R:V65	2.87	No	No	0	4	7
250	R:R:I440	R:R:L181	2.85	No	No	0	8	4
251	R:R:I438	R:R:L442	2.85	No	No	0	6	9
252	R:R:A115	R:R:F200	2.77	No	Yes	0	8	8
253	R:R:A115	R:R:F443	2.77	No	No	0	8	8
254	R:R:A397	R:R:F216	2.77	No	Yes	0	8	7
255	R:R:A398	R:R:F216	2.77	No	Yes	0	8	7
256	R:R:A180	R:R:W97	2.59	No	Yes	0	4	9
257	R:R:R147	R:R:T144	2.59	No	No	0	8	9
258	R:R:H135	R:R:L131	2.57	Yes	No	0	7	6
259	R:R:M143	R:R:R147	2.48	No	No	0	8	8
260	R:R:V420	R:R:W424	2.45	No	No	0	7	7
261	R:R:F96	R:R:L99	2.44	No	No	0	4	7
262	R:R:F406	R:R:L410	2.44	No	No	0	8	5
263	R:R:L150	R:R:R146	2.43	No	No	0	4	6
264	R:R:L131	R:R:Y139	2.34	No	Yes	0	6	8
265	R:R:L195	R:R:Y192	2.34	No	Yes	0	6	8
266	R:R:G171	R:R:P166	2.03	No	Yes	0	7	8
267	R:R:A85	R:R:P86	1.87	No	No	0	8	9
268	R:R:G48	R:R:V51	1.84	No	No	0	9	8
269	R:R:G187	R:R:V423	1.84	No	No	0	5	8
270	R:R:A117	R:R:A159	1.79	No	No	0	9	9
271	R:R:A219	R:R:A397	1.79	No	No	0	8	8
272	R:R:P166	R:R:S109	1.78	Yes	No	0	8	8
273	R:R:P166	R:R:T105	1.75	Yes	No	0	8	7
274	R:R:C211	R:R:V127	1.71	No	No	0	8	7
275	R:R:C211	R:R:V207	1.71	No	No	0	8	7
276	R:R:A422	R:R:V427	1.7	No	No	0	5	4
277	R:R:K59	R:R:P60	1.67	No	No	0	7	8
278	R:R:A29	R:R:I33	1.62	No	No	0	4	4
279	R:R:A218	R:R:I134	1.62	No	Yes	0	7	8
280	R:R:A174	R:R:I185	1.62	No	No	0	3	7
281	R:R:S101	R:R:T105	1.6	No	No	0	4	7
282	R:R:V197	R:R:V420	1.6	No	No	0	8	7
283	R:R:A85	R:R:L42	1.58	No	Yes	0	8	8
284	R:R:P60	R:R:Q61	1.58	No	No	0	8	6
285	R:R:I40	R:R:V39	1.54	No	No	0	6	5
286	R:R:I203	R:R:V198	1.54	No	No	0	6	6
287	R:R:I206	R:R:V202	1.54	No	No	0	4	6
288	R:R:I404	R:R:V400	1.54	No	No	0	9	9
289	R:R:H135	R:R:P136	1.53	Yes	No	0	7	9
290	R:R:M468	R:R:V51	1.52	Yes	No	0	7	8
291	R:R:L421	R:R:V425	1.49	No	No	0	7	8
292	R:R:L161	R:R:T164	1.47	No	No	0	6	7
293	R:R:I209	R:R:I405	1.47	No	No	0	7	8
294	R:R:G154	R:R:Y153	1.45	No	No	0	5	6
295	R:R:K471	R:R:M468	1.44	No	Yes	0	6	7
296	R:R:I50	R:R:L54	1.43	No	No	0	6	5
297	R:R:I157	R:R:L161	1.43	No	No	0	5	6
298	R:R:H30	R:R:S27	1.39	No	No	0	5	7
299	R:R:K470	R:R:Q466	1.36	No	No	0	5	7
300	R:R:P98	R:R:W97	1.35	No	Yes	0	4	9
301	R:R:C392	R:R:Y393	1.34	No	Yes	0	6	7
302	R:R:R146	R:R:T144	1.29	No	No	0	6	9
303	R:R:F41	R:R:I40	1.26	Yes	No	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:R34	5.198	5	0	5
2	R:R:L38	4.736	5	1	6
3	R:R:F41	6.57833	6	1	7
4	R:R:L42	6.86	4	1	8
5	R:R:S45	3.9975	4	1	9
6	R:R:N49	6.9675	4	0	9
7	R:R:L63	7.9325	4	5	8
8	R:R:F69	5.73	4	6	8
9	R:R:L73	6.29	4	1	9
10	R:R:D77	8.3075	4	1	9
11	R:R:I81	4.975	4	1	8
12	R:R:W97	3.80833	6	0	9
13	R:R:H112	5.7325	4	2	8
14	R:R:L113	4.23	4	0	8
15	R:R:F114	6.472	5	0	6
16	R:R:F116	13.0275	4	2	9
17	R:R:S118	4.8175	4	1	9
18	R:R:Y130	6.95	4	3	8
19	R:R:I134	6.6275	4	3	8
20	R:R:H135	5.5825	4	3	7
21	R:R:Y139	6.094	5	0	8
22	R:R:W156	6.86	4	1	9
23	R:R:P165	8.284	5	2	9
24	R:R:P166	4.228	5	2	8
25	R:R:W170	5.938	5	2	6
26	R:R:M184	7.115	4	2	7
27	R:R:W186	9.04	7	2	7
28	R:R:Y192	6.24	5	2	8
29	R:R:F200	9.5	4	0	8
30	R:R:P204	4.35	4	1	9
31	R:R:Y212	5.65833	6	1	9
32	R:R:F216	4.1975	4	0	7
33	R:R:Y393	8.9725	4	7	7
34	R:R:Y408	5.486	5	1	9
35	R:R:L412	5.0525	4	1	9
36	R:R:Q446	6.172	5	1	9
37	R:R:C447	4.775	4	1	9
38	R:R:H450	9.02333	6	1	9
39	R:R:Y454	7.536	5	0	9
40	R:R:M468	2.81	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I26	R:R:W97	43.0489	3.52	No	Yes	0	6	9
2	R:R:I26	R:R:R34	46.8043	3.76	No	Yes	0	6	5
3	R:R:P94	R:R:W97	12.6399	8.11	No	Yes	0	6	9
4	R:R:R34	R:R:T437	17.3141	11.64	Yes	No	0	5	6
5	R:R:R34	R:R:S92	85.6518	3.95	Yes	No	0	5	6
6	R:R:L181	R:R:R34	25.717	3.64	No	Yes	0	4	5
7	R:R:S92	R:R:V89	86.7178	3.23	No	No	1	6	7
8	R:R:T437	R:R:W441	13.1662	8.49	No	No	0	6	8
9	R:R:L38	R:R:V89	89.5723	2.98	Yes	No	1	6	7
10	R:R:F41	R:R:L38	21.0963	8.53	Yes	Yes	1	7	6
11	R:R:L38	R:R:L42	72.9138	5.54	Yes	Yes	1	6	8
12	R:R:C448	R:R:F41	26.9033	6.98	No	Yes	1	8	7
13	R:R:I81	R:R:L42	79.0152	5.71	Yes	Yes	1	8	8
14	R:R:C448	R:R:S45	29.7578	3.44	No	Yes	1	8	9
15	R:R:N49	R:R:S45	50.475	4.47	Yes	Yes	0	9	9
16	R:R:I81	R:R:S45	22.4254	4.64	Yes	Yes	1	8	9
17	R:R:C447	R:R:I81	60.8224	3.27	Yes	Yes	1	9	8
18	R:R:L74	R:R:N49	100	8.24	No	Yes	0	9	9
19	R:R:C447	R:R:D77	36.729	9.34	Yes	Yes	1	9	9
20	R:R:L52	R:R:L74	97.7253	4.15	No	No	0	9	9
21	R:R:G455	R:R:L52	96.5746	3.42	No	No	0	9	9
22	R:R:G455	R:R:I461	95.415	5.29	No	No	0	9	8
23	R:R:H458	R:R:I461	35.0029	7.95	No	No	5	9	8
24	R:R:H458	R:R:T460	37.786	8.21	No	No	0	9	8
25	R:R:L62	R:R:T460	36.2339	2.95	No	No	0	9	8
26	R:R:E464	R:R:L62	34.6684	7.95	No	No	0	9	9
27	R:R:E464	R:R:K59	33.094	12.15	No	No	0	9	7
28	R:R:K59	R:R:R58	28.335	4.95	No	No	0	7	8
29	R:R:M468	R:R:R58	26.7205	3.72	Yes	No	0	7	8
30	R:R:M468	R:R:V55	20.2444	4.56	Yes	No	0	7	9
31	R:R:I465	R:R:V55	18.6031	6.14	No	No	0	8	9
32	R:R:I461	R:R:L63	59.2079	4.28	No	Yes	5	8	8
33	R:R:L63	R:R:T66	55.1626	8.84	Yes	No	0	8	8
34	R:R:D128	R:R:T66	53.6907	5.78	No	No	0	9	8
35	R:R:D128	R:R:Y139	46.6438	10.34	No	Yes	0	9	8
36	R:R:M143	R:R:Y139	18.7101	5.99	No	Yes	0	8	8
37	R:R:M143	R:R:V65	10.3251	4.56	No	No	0	8	7
38	R:R:D77	R:R:S118	25.6679	5.89	Yes	Yes	1	9	9
39	R:R:L73	R:R:S118	20.5209	3	Yes	Yes	1	9	9
40	R:R:L73	R:R:Y454	36.8226	4.69	Yes	Yes	0	9	9
41	R:R:D77	R:R:H450	62.1025	12.61	Yes	Yes	1	9	9
42	R:R:H450	R:R:L73	22.4388	11.57	Yes	Yes	1	9	9
43	R:R:H450	R:R:I122	19.513	7.95	Yes	No	0	9	8
44	R:R:I122	R:R:Y454	18.5094	10.88	No	Yes	0	8	9
45	R:R:C447	R:R:Q80	39.4585	3.05	Yes	No	0	9	8
46	R:R:F114	R:R:Q80	13.0235	12.88	Yes	No	0	6	8
47	R:R:Q446	R:R:Q80	33.4419	3.84	Yes	No	0	9	8
48	R:R:F175	R:R:W97	23.0409	4.01	No	Yes	0	5	9
49	R:R:F175	R:R:L99	12.5017	8.53	No	No	0	5	7
50	R:R:F443	R:R:Q446	33.5444	4.68	No	Yes	0	8	9
51	R:R:F443	R:R:Y415	32.028	11.35	No	No	0	8	9
52	R:R:M184	R:R:W186	25.1639	18.61	Yes	Yes	2	7	7
53	R:R:W186	R:R:Y415	28.5937	6.75	Yes	No	2	7	9
54	R:R:M184	R:R:Y192	26.9435	3.59	Yes	Yes	2	7	8
55	R:R:L412	R:R:Q446	33.4508	3.99	Yes	Yes	1	9	9
56	R:R:F200	R:R:L412	21.6984	8.53	Yes	Yes	0	8	9
57	R:R:F116	R:R:F200	14.9547	22.51	Yes	Yes	0	9	8
58	R:R:L412	R:R:Y408	28.9372	4.69	Yes	Yes	1	9	9
59	R:R:M208	R:R:Y408	17.8092	4.79	No	Yes	1	9	9
60	R:R:R129	R:R:Y454	39.6057	8.23	No	Yes	0	9	9
61	R:R:R129	R:R:Y212	37.2508	7.2	No	Yes	0	9	9
62	R:R:M208	R:R:Y212	15.5881	3.59	No	Yes	1	9	9
63	R:R:L131	R:R:Y139	21.6895	2.34	No	Yes	0	6	8
64	R:R:H135	R:R:L131	16.7388	2.57	Yes	No	0	7	6
65	R:R:D176	R:R:L181	22.5637	4.07	No	No	0	5	4
66	R:R:D176	R:R:N179	19.1561	12.12	No	No	0	5	4
67	R:R:I436	R:R:N179	12.2341	9.91	No	No	0	5	4
68	R:R:C416	R:R:F200	10.0575	4.19	No	Yes	0	8	8
69	R:R:I401	R:R:Y212	41.1935	7.25	No	Yes	0	9	9
70	R:R:F216	R:R:I401	38.0358	3.77	Yes	No	0	7	9
71	R:R:F216	R:R:R220	25.6188	7.48	Yes	No	0	7	7
72	R:R:Q394	R:R:R220	22.4254	22.2	No	No	0	8	7
73	R:R:H223	R:R:Q394	16.1545	9.89	No	No	0	6	8
74	R:R:I465	R:R:Y456	16.9395	3.63	No	No	0	8	7
75	R:R:D77	R:R:N49	57.5041	5.39	Yes	Yes	0	9	9
76	R:R:H450	R:R:Q446	28.1299	11.13	Yes	Yes	1	9	9
77	R:R:F116	R:R:H112	10.0843	3.39	Yes	Yes	2	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8W8Q_nogp

PDB Summary
PDB	8W8Q_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	268
Number of Links	303
Number of Hubs	40
Number of Links mediated by Hubs	146
Number of Communities	7
Number of Nodes involved in Communities	61
Number of Links involved in Communities	82

Path Summary
Number Of Nodes in MetaPath	78
Number Of Links MetaPath	77
Number of Shortest Paths	52476
Length Of Smallest Path	3
Average Path Length	15.789
Length of Longest Path	34
Minimum Path Strength	1.4
Average Path Strength	6.15761
Maximum Path Strength	22.38
Minimum Path Correlation	0.7
Average Path Correlation	0.925315
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	43.0944
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.4275
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • positive regulation of MAPK cascade • biological regulation • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adrenergic receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular anatomical structure • periplasmic space • protein-containing complex • receptor complex • cell periphery • plasma membrane • membrane • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of metabolic process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96P66
Sequence	>8W8Q_nogp_Chain_R P I S L A H G I I R S T V L V I F L A A S F V G N I V L A L V L Q R K P Q L L Q V T N R F I F N L L V T D L L Q I S L V A P W V V A T S V P L F W P L N S H F C T A L V S L T H L F A F A S V N T I V V V S V D R Y L S I I H P L S Y P S K M T Q R R G Y L L L Y G T W I V A I L Q S T P P L Y G W G Q A A F D E R N A L C S M I W G A S P S Y T I L S V V S F I V I P L I V M I A C Y S V V F C A A R R Q H A L L Y N R C Y Q C K A A K V I F I I I F S Y V L S L G P Y C F L A V L A V W V D V E T Q V P Q W V I T I I I W L F F L Q C C I H P Y V Y G Y M H K T I K K E I Q D M L K K F F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8W8R	A	Orphan	Orphan	GPR101	Homo sapiens	-	AA-14	chim(NtGi1-Gs)/β1/γ2	3.3	2024-01-03	doi.org/10.1038/s41589-023-01456-6
	8W8R (No Gprot)	A	Orphan	Orphan	GPR101	Homo sapiens	-	AA-14		3.3	2024-01-03	doi.org/10.1038/s41589-023-01456-6
	8W8S	A	Orphan	Orphan	GPR101	Homo sapiens	-	AA-14	-	3.3	2024-01-03	doi.org/10.1038/s41589-023-01456-6
	8W8Q	A	Orphan	Orphan	GPR101	Homo sapiens	-	-	Gs/β1/γ2	2.89	2024-01-03	doi.org/10.1038/s41589-023-01456-6
	8W8Q (No Gprot)	A	Orphan	Orphan	GPR101	Homo sapiens	-	-		2.89	2024-01-03	doi.org/10.1038/s41589-023-01456-6

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