Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:I64 3.42667606
2R:R:F77 3.90167607
3R:R:F80 5.7675447
4R:R:L83 4.3725449
5R:R:L86 5.338548
6R:R:L88 3.888549
7R:R:N91 6.6325449
8R:R:H97 8.00254208
9R:R:L110 4.984549
10R:R:Q113 8.9454179
11R:R:L131 3.8075449
12R:R:L134 4.4975409
13R:R:R135 11.06254179
14R:R:L136 3.725409
15R:R:D137 8.3545179
16R:R:V144 4.825149
17R:R:S148 3.4954148
18R:R:L155 3.876549
19R:R:L158 4.85549
20R:R:L160 4.84409
21R:R:P172 3.9954149
22R:R:L179 3.322549
23R:R:L182 4.15167648
24R:R:I189 4.665489
25R:R:P193 3.045409
26R:R:F195 5.72754222
27R:R:F197 4.404509
28R:R:L203 3.324549
29R:R:L206 3.60667649
30R:R:H207 5.8075479
31R:R:L208 2.765409
32R:R:H209 6.448579
33R:R:N211 5.572589
34R:R:L216 4.3054186
35R:R:F221 4.481437189
36R:R:L230 4.6775409
37R:R:Y234 8.41476
38R:R:F240 5.84629
39R:R:L247 3.4409
40R:R:L253 4.205429
41R:R:F255 3.57625829
42R:R:H256 16.0525479
43R:R:I263 3.34409
44R:R:F268 3.8831029
45R:R:N271 4.00833629
46R:R:L274 4.725429
47R:R:R275 7.6175405
48R:R:I277 4.29167628
49R:R:L279 3.915428
50R:R:N282 3.47429
51R:R:F292 4.25875829
52R:R:L295 2.605429
53R:R:L301 5.54429
54R:R:I303 3.1225428
55R:R:F312 5.78143728
56R:R:L324 3.532529
57R:R:T325 5.5825458
58R:R:L326 3.86527
59R:R:T327 3.62833659
60R:R:I334 4.734507
61R:R:Q342 7.1625408
62R:R:L348 4.07409
63R:R:D349 6.9325458
64R:R:L350 3.826529
65R:R:S351 4.4425459
66R:R:N354 2.61754243
67R:R:F361 3.67333636
68R:R:L367 4.125437
69R:R:I370 4.08637
70R:R:S371 5.2175456
71R:R:L372 4.5175408
72R:R:I377 6.4175437
73R:R:I380 5.812537
74R:R:F385 5.715639
75R:R:Q386 5.75404
76R:R:L394 7.175437
77R:R:L396 4.928539
78R:R:N399 5.2175439
79R:R:I401 5.774538
80R:R:I404 6.398537
81R:R:H405 4.9175406
82R:R:F409 5.595438
83R:R:L418 3.72833639
84R:R:D419 6.265459
85R:R:V420 3.2575406
86R:R:S421 4.0475457
87R:R:F422 9.675454
88R:R:F428 4.48333634
89R:R:L433 5.072539
90R:R:L439 4.994538
91R:R:L447 2.9175417
92R:R:F456 3.568505
93R:R:L462 4.5625407
94R:R:V464 3.75517
95R:R:P465 5.525419
96R:R:Y466 4.72616
97R:R:Y468 6.58833619
98R:R:Q469 5.524519
99R:R:F473 4.305408
100R:R:F529 7.35254138
101R:R:Y534 6.4375414
102R:R:L535 6.225419
103R:R:I541 3.0154267
104R:R:R542 7.496519
105R:R:W546 8.094159
106R:R:F549 4.9365155
107R:R:F576 4.3725116
108R:R:L579 4.0354167
109R:R:N584 4.862509
110R:R:M587 4.436566
111R:R:Y590 6.376505
112R:R:T595 7.2665157
113R:R:F605 6.10143719
114R:R:F608 4.908504
115R:R:I610 3.6325417
116R:R:W612 4.54619
117R:R:E613 6.0875419
118R:R:F627 4.6125405
119R:R:E630 7.4125408
120R:R:I633 3.0375406
121R:R:L635 2.8045165
122R:R:L636 4.1954129
123R:R:E642 9.19254118
124R:R:R643 7.82754118
125R:R:F662 5.9165114
126R:R:F670 4.88254163
127R:R:P680 8.2225467
128R:R:E686 6.5475404
129R:R:Y687 6.832565
130R:R:P691 5.31519
131R:R:L694 5.13567
132R:R:P695 4.848569
133R:R:F696 4.5325467
134R:R:T701 5.174284
135R:R:L704 3.6254286
136R:R:F706 8.0625465
137R:R:F718 5.126506
138R:R:M721 4.65754127
139R:R:Y725 5.7065128
140R:R:M745 3.7454107
141R:R:H748 9.8654109
142R:R:I753 3.925129
143R:R:N756 4.2225409
144R:R:F759 6.4585199
145R:R:F760 6.275408
146R:R:I781 3.654138
147R:R:F790 4.942565
148R:R:P791 4.5925469
149R:R:L796 3.0354198
150R:R:Y801 8.7565109
151R:R:N805 7.34754108
152R:R:F808 7.912507
153R:R:L815 3.1475407
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:I64 R:R:L88 14.18632.85YesYes069
2R:R:G90 R:R:N115 12.69091.7NoNo099
3R:R:G90 R:R:N114 11.77251.7NoNo099
4R:R:L110 R:R:L86 15.9615.54YesYes498
5R:R:L112 R:R:L88 22.24324.15NoYes099
6R:R:L117 R:R:N115 10.85422.75NoNo089
7R:R:H207 R:R:T183 10.15255.48YesNo099
8R:R:H207 R:R:V205 12.58115.54YesNo099
9R:R:L110 R:R:L134 19.484.15YesYes099
10R:R:L112 R:R:L136 20.34162.77NoYes099
11R:R:L117 R:R:N139 15.35396.87NoNo089
12R:R:L134 R:R:L158 22.81622.77YesYes099
13R:R:L136 R:R:L160 14.21732.77YesYes099
14R:R:L160 R:R:N163 18.12522.75YesNo099
15R:R:L158 R:R:L182 35.5364.15YesYes498
16R:R:L173 R:R:P169 10.30354.93NoNo099
17R:R:L160 R:R:L184 24.43724.15YesNo099
18R:R:L184 R:R:L208 16.43392.77NoYes099
19R:R:L182 R:R:L206 49.37634.15YesYes489
20R:R:L206 R:R:L208 10.11782.77YesYes099
21R:R:L206 R:R:L230 65.9824.15YesYes099
22R:R:T229 R:R:V205 13.65474.76NoNo099
23R:R:E252 R:R:T229 13.77818.47NoNo099
24R:R:E252 R:R:T276 13.757.06NoNo2398
25R:R:R275 R:R:T276 14.39692.59YesNo058
26R:R:L230 R:R:L253 82.81084.15YesYes099
27R:R:F255 R:R:L253 38.3844.87YesYes299
28R:R:F268 R:R:L253 46.22323.65YesYes299
29R:R:F255 R:R:L279 39.4526.09YesYes298
30R:R:F268 R:R:F292 48.74656.43YesYes299
31R:R:I303 R:R:L279 39.75682.85YesYes288
32R:R:F292 R:R:I303 42.06632.51YesYes298
33R:R:E341 R:R:Q342 18.081614.02NoYes058
34R:R:E341 R:R:V319 17.83362.85NoNo054
35R:R:H299 R:R:R275 15.50382.26NoYes075
36R:R:H320 R:R:V319 16.35454.15NoNo074
37R:R:H299 R:R:H320 15.89122.39NoNo077
38R:R:I303 R:R:L326 81.95082.85YesYes287
39R:R:L326 R:R:L350 81.80154.15YesYes279
40R:R:L350 R:R:L372 1004.15YesYes098
41R:R:I370 R:R:L394 10.66472.85YesYes377
42R:R:L394 R:R:L418 21.27294.15YesYes379
43R:R:L418 R:R:L439 17.91234.15YesYes398
44R:R:L439 R:R:L462 19.6124.15YesYes087
45R:R:L462 R:R:V464 16.48294.47YesYes077
46R:R:P524 R:R:V464 11.4593.53NoYes097
47R:R:P524 R:R:T523 10.97413.5NoNo096
48R:R:S463 R:R:T523 10.48947.99NoNo086
49R:R:K440 R:R:S463 10.00486.12NoNo088
50R:R:L324 R:R:L348 10.82434.15YesYes099
51R:R:F361 R:R:L348 10.55022.44YesYes069
52R:R:L372 R:R:L396 92.33894.15YesYes089
53R:R:L396 R:R:V420 85.44084.47YesYes096
54R:R:L425 R:R:V420 79.79842.98NoYes096
55R:R:L425 R:R:N444 83.98298.24NoNo099
56R:R:L447 R:R:N444 84.29082.75YesNo079
57R:R:L447 R:R:Q469 80.67512.66YesYes179
58R:R:L338 R:R:Q342 16.17033.99NoYes058
59R:R:I610 R:R:Q469 83.84394.12YesYes179
60R:R:I610 R:R:Y468 86.11232.42YesYes179
61R:R:F605 R:R:Y468 41.90084.13YesYes199
62R:R:P691 R:R:Y468 43.53944.17YesYes199
63R:R:P691 R:R:S690 41.0485.34YesNo098
64R:R:F605 R:R:L597 38.5292.44YesNo198
65R:R:L597 R:R:W612 38.682410.25NoYes189
66R:R:A621 R:R:W612 38.03492.59NoYes159
67R:R:A621 R:R:Y590 38.00172.67NoYes055
68R:R:M587 R:R:Y590 57.83424.79YesYes065
69R:R:L692 R:R:S690 38.06723NoNo078
70R:R:L594 R:R:L692 37.93012.77NoNo097
71R:R:L594 R:R:Y590 37.830510.55NoYes095
72R:R:A794 R:R:M587 37.11353.22NoYes086
73R:R:A794 R:R:N584 36.854.69NoYes089
74R:R:N584 R:R:N797 22.12076.81YesNo099
75R:R:L752 R:R:N797 14.48174.12NoNo099
76R:R:M587 R:R:S628 13.25724.6YesNo068
77R:R:F586 R:R:S628 12.9763.96NoNo068
78R:R:F586 R:R:F627 12.41487.5NoYes065
79R:R:F627 R:R:F670 10.60154.29YesYes053
80R:R:F670 R:R:L579 10.23354.87YesYes1637
81R:R:L575 R:R:L579 19.97545.54NoYes067
82R:R:F576 R:R:L575 18.86142.44YesNo066
83R:R:P571 R:R:S573 12.88411.78NoNo075
84R:R:I580 R:R:N584 11.19344.25NoYes079
85R:R:I580 R:R:L635 10.91262.85NoYes075
86R:R:L579 R:R:L635 10.29614.15YesYes1675
87R:R:F576 R:R:F662 10.27276.43YesYes1164
88R:R:L694 R:R:Y590 18.55385.86YesYes075
89R:R:L694 R:R:P695 14.58014.93YesYes679
90R:R:E686 R:R:P680 10.82133.14YesYes047
91R:R:N139 R:R:N163 16.22826.81NoNo2199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8XT9
Class A
SubFamily Orphan
Type Orphan
SubType LGR4
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.1
Date 2025-01-15
D.O.I. doi.org/10.1016/j.molcel.2025.01.024
Net Summary
Imin 2.42
Number of Linked Nodes 696
Number of Links 889
Number of Hubs 153
Number of Links mediated by Hubs 531
Number of Communities 28
Number of Nodes involved in Communities 216
Number of Links involved in Communities 312
Path Summary
Number Of Nodes in MetaPath 92
Number Of Links MetaPath 91
Number of Shortest Paths 1524686
Length Of Smallest Path 3
Average Path Length 27.4686
Length of Longest Path 55
Minimum Path Strength 1.23667
Average Path Strength 4.72331
Maximum Path Strength 23.49
Minimum Path Correlation 0.75
Average Path Correlation 0.992959
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 4.7619
Average % Of Corr. Nodes 54.6251
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 63.3149
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .


This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XT9AOrphanOrphanLGR4Homo sapiens---3.12025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XUMAOrphanOrphanLGR4Homo sapiensR-spondin-2--2.92025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XFPAOrphanOrphanLGR4Homo sapiensR-spondin-2-ZNRF33.212024-12-04doi.org/10.1038/s41467-024-55431-3
8XFSAOrphanOrphanLGR4Homo sapiensR-spondin-2-ZNRF33.22024-12-04doi.org/10.1038/s41467-024-55431-3
8XFTAOrphanOrphanLGR4Homo sapiensR-spondin-2-ZNRF33.242024-12-04doi.org/10.1038/s41467-024-55431-3
8Y69AOrphanOrphanLGR4Homo sapiensR-spondin-2-ZNRF33.382024-12-04doi.org/10.1038/s41467-024-55431-3
8WVUAOrphanOrphanLGR4Homo sapiensR-spondin-1-RNF433.612024-10-30To be published
8WVVAOrphanOrphanLGR4Homo sapiens---3.352024-10-30To be published
8WVWAOrphanOrphanLGR4Homo sapiens---3.532024-10-30To be published
8WVXAOrphanOrphanLGR4Homo sapiensNorrin--3.322024-10-30To be published
8WVYAOrphanOrphanLGR4Homo sapiensNorrin--3.292024-10-30To be published
9KGKAOrphanOrphanLGR4Homo sapiens---2.632025-07-16To be published
9KHHAOrphanOrphanLGR4Homo sapiensNorrin--3.652025-07-16To be published
9S37AOrphanOrphanLGR4Homo sapiensNB21--3.942025-07-30To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XT9.zip



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