Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:R40 10.912533
2R:R:D42 10.015439
3R:R:K46 6.7375484
4R:R:P52 3.7825408
5R:R:L62 4.172515
6R:R:D63 8.1975439
7R:R:F77 6.095407
8R:R:F80 4.912517
9R:R:L86 4.8425418
10R:R:Q87 8.225438
11R:R:N91 5.1975499
12R:R:L93 5.5375409
13R:R:L110 3.92619
14R:R:Q113 6.38639
15R:R:L117 5.3525418
16R:R:V120 5.1375407
17R:R:P121 4.2425418
18R:R:S122 3.4425405
19R:R:L128 4.405619
20R:R:L131 5.1925419
21R:R:L134 5.19409
22R:R:R135 14.92439
23R:R:L136 5.96409
24R:R:D137 5.544539
25R:R:N139 8.255419
26R:R:I141 6.1475419
27R:R:V144 5.462519
28R:R:S148 5.555418
29R:R:F149 6.3175419
30R:R:L152 3.736518
31R:R:L155 4.1525419
32R:R:H157 8.445439
33R:R:L158 5.582519
34R:R:W159 11.994539
35R:R:N163 4.83419
36R:R:L165 6.585419
37R:R:V168 3.344518
38R:R:P172 5.062519
39R:R:L176 4.348519
40R:R:L179 5.53667619
41R:R:L182 4.845618
42R:R:L184 3.634509
43R:R:L186 7.4325469
44R:R:I192 3.685618
45R:R:F197 5.516519
46R:R:L200 4.985419
47R:R:L203 3.876519
48R:R:V204 5.14409
49R:R:V205 4.5975409
50R:R:L206 3.72667619
51R:R:H209 5.748569
52R:R:I213 4.65419
53R:R:L216 4.1225416
54R:R:C220 4.695415
55R:R:F221 4.48667619
56R:R:L224 5.1625419
57R:R:L230 4.01333619
58R:R:L232 3.24409
59R:R:N235 5.784519
60R:R:N236 3.9525405
61R:R:L237 5.8675418
62R:R:F240 4.92714719
63R:R:P241 4.405409
64R:R:L247 4.772519
65R:R:L250 5.87419
66R:R:L253 4.716519
67R:R:H256 13.314569
68R:R:N258 6.56419
69R:R:F268 4.372519
70R:R:I277 4.1525408
71R:R:V287 4.7175409
72R:R:G288 2.5825409
73R:R:F292 5.6325419
74R:R:L295 3.7275409
75R:R:L301 5.372519
76R:R:I303 4.52418
77R:R:F312 6.504518
78R:R:N314 6.3554127
79R:R:L315 4.7425419
80R:R:L321 4.79418
81R:R:L324 3.69167619
82R:R:T325 7.4375448
83R:R:L326 4.322517
84R:R:T327 5.06449
85R:R:I334 5.295617
86R:R:E341 3.175405
87R:R:Q342 4.0275418
88R:R:L348 4.632519
89R:R:D349 6.9325448
90R:R:L350 5.462519
91R:R:I355 6.5425418
92R:R:L358 5.46418
93R:R:F361 3.9375416
94R:R:G363 3.7575404
95R:R:C364 5.295419
96R:R:L367 5.1425417
97R:R:I370 4.40333617
98R:R:L372 4.462518
99R:R:N375 5.566519
100R:R:I377 5.72833617
101R:R:I380 4.75517
102R:R:F385 5.2275419
103R:R:L388 5.29418
104R:R:L391 6.3025419
105R:R:L394 4.7517
106R:R:D395 7.1425449
107R:R:L396 3.985419
108R:R:I401 4.636518
109R:R:I404 6.80833617
110R:R:F409 5.145618
111R:R:L412 3.585418
112R:R:L418 4.33519
113R:R:D419 10.515449
114R:R:V420 3.9075416
115R:R:S421 4.6975447
116R:R:F422 8.575444
117R:R:N423 4.9225409
118R:R:F428 5.724514
119R:R:L433 7.46419
120R:R:L436 6.6075418
121R:R:L439 4.27618
122R:R:K440 8.405448
123R:R:L441 4.665618
124R:R:L451 4.69417
125R:R:F456 5.2875815
126R:R:L462 5.86333617
127R:R:V464 6.032517
128R:R:Y466 6.168516
129R:R:Y468 6.10286719
130R:R:Q469 6.535419
131R:R:C470 5.7475419
132R:R:F473 6.49418
133R:R:T526 4.5465158
134R:R:Y534 10.3025414
135R:R:L535 5.32167619
136R:R:L536 6.148515
137R:R:I541 4.146517
138R:R:R542 8.9625419
139R:R:F549 5.05505
140R:R:N556 6.6675409
141R:R:I560 3.714164
142R:R:T563 5.706524
143R:R:L570 6.6425424
144R:R:K574 6.756527
145R:R:L579 4.068577
146R:R:N584 4.60667679
147R:R:M587 5.5175456
148R:R:F605 6.14667619
149R:R:I610 5.14417
150R:R:W612 5.45667609
151R:R:F623 4.245404
152R:R:F627 4.445405
153R:R:L635 3.525675
154R:R:L636 5.2425409
155R:R:T640 4.58254197
156R:R:E642 6.546508
157R:R:R643 6.622528
158R:R:F670 5.49473
159R:R:S690 4.4725408
160R:R:P691 5.69333619
161R:R:L692 4.268517
162R:R:L694 7.5475457
163R:R:F696 8.4825457
164R:R:F706 7.1256185
165R:R:N714 7.86409
166R:R:M721 5.0654197
167R:R:Y725 7.412528
168R:R:M745 5.4425427
169R:R:H748 9.0175429
170R:R:L752 6.035409
171R:R:F759 8.014559
172R:R:F760 5.475608
173R:R:M782 3.9125405
174R:R:L787 5.348519
175R:R:F789 3.7225457
176R:R:F790 6.48655
177R:R:L792 4.9075459
178R:R:Y801 6.13286729
179R:R:N805 6.30833628
180R:R:K807 4.9975426
181R:R:F808 8.8225407
182R:R:D811 6.355429
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:H157 R:R:W159 12.37635.29YesYes399
2R:R:R135 R:R:W159 10.462637.99YesYes399
3R:R:L110 R:R:L134 13.26724.15YesYes099
4R:R:L134 R:R:L158 13.15132.77YesYes099
5R:R:L158 R:R:L182 17.25496.92YesYes198
6R:R:L182 R:R:L206 22.38832.77YesYes189
7R:R:L206 R:R:L230 25.98614.15YesYes199
8R:R:E228 R:R:V204 14.17214.28NoYes099
9R:R:L230 R:R:L253 35.34574.15YesYes199
10R:R:F268 R:R:L253 36.57153.65YesYes199
11R:R:F240 R:R:F268 10.58485.36YesYes199
12R:R:E228 R:R:K251 14.21946.75NoNo099
13R:R:K251 R:R:R275 14.276918.56NoNo095
14R:R:R275 R:R:T276 10.03796.47NoNo058
15R:R:F268 R:R:F292 46.43986.43YesYes199
16R:R:F292 R:R:L301 45.63237.31YesYes199
17R:R:H299 R:R:R275 24.28452.26NoNo075
18R:R:E322 R:R:H299 24.34138.62NoNo087
19R:R:L301 R:R:L324 44.88454.15YesYes199
20R:R:E322 R:R:R346 24.46526.98NoNo087
21R:R:R346 R:R:T347 24.54823.88NoNo076
22R:R:L324 R:R:L348 51.46232.77YesYes199
23R:R:C339 R:R:C364 17.16527.28NoYes099
24R:R:E369 R:R:T347 24.09098.47NoNo076
25R:R:I370 R:R:L348 50.98664.28YesYes179
26R:R:I370 R:R:L394 57.35032.85YesYes177
27R:R:L394 R:R:L418 59.74045.54YesYes179
28R:R:L418 R:R:L439 62.64744.15YesYes198
29R:R:L439 R:R:L441 34.66754.15YesYes188
30R:R:L441 R:R:V464 47.69242.98YesYes187
31R:R:F445 R:R:Y466 31.22172.06NoYes016
32R:R:F445 R:R:G443 31.08914.52NoNo018
33R:R:F422 R:R:G443 30.95674.52YesNo048
34R:R:L439 R:R:L462 35.5114.15YesYes187
35R:R:L462 R:R:V464 36.43324.47YesYes177
36R:R:C339 R:R:G363 16.09361.96NoYes094
37R:R:G363 R:R:N362 12.87783.39YesNo044
38R:R:E369 R:R:I393 24.189512.3NoNo074
39R:R:I393 R:R:N417 24.29684.25NoNo047
40R:R:G387 R:R:N362 11.80551.7NoNo054
41R:R:N417 R:R:Q438 25.850614.52NoNo079
42R:R:K440 R:R:Q438 26.35848.14YesNo089
43R:R:K440 R:R:S421 26.37683.06YesYes487
44R:R:F422 R:R:S421 30.11076.61YesYes447
45R:R:Q469 R:R:V464 76.480815.76YesYes197
46R:R:I610 R:R:Q469 76.54844.12YesYes179
47R:R:I610 R:R:Y468 1006.04YesYes179
48R:R:F605 R:R:Y468 31.47886.19YesYes199
49R:R:P691 R:R:Y468 68.8064.17YesYes199
50R:R:F605 R:R:L535 29.85416.09YesYes199
51R:R:L535 R:R:P691 30.09666.57YesYes199
52R:R:P691 R:R:S690 39.31553.56YesYes098
53R:R:F529 R:R:S690 13.14596.61NoYes088
54R:R:F529 R:R:M782 13.06424.98NoYes085
55R:R:L535 R:R:L692 52.30412.77YesYes197
56R:R:L692 R:R:S690 26.15986.01YesYes078
57R:R:F766 R:R:M782 11.59276.22NoYes095
58R:R:F766 R:R:V785 11.35792.62NoNo097
59R:R:F789 R:R:V785 11.24072.62YesNo077
60R:R:L594 R:R:L692 77.65692.77NoYes097
61R:R:L594 R:R:Y590 77.29163.52NoNo095
62R:R:L694 R:R:Y590 76.56168.21YesNo075
63R:R:F790 R:R:L694 73.918612.18YesYes557
64R:R:F790 R:R:M587 62.14626.22YesYes556
65R:R:A794 R:R:M587 61.54024.83NoYes086
66R:R:A794 R:R:N584 61.16756.25NoYes089
67R:R:N556 R:R:N584 11.58064.09YesYes099
68R:R:N584 R:R:N797 26.92975.45YesNo099
69R:R:L752 R:R:N797 26.17329.61YesNo099
70R:R:H748 R:R:L752 34.45879YesYes099
71R:R:F759 R:R:F789 10.10224.29YesYes597
72R:R:I580 R:R:N584 15.04314.25NoYes079
73R:R:H748 R:R:I577 11.306613.26YesNo295
74R:R:I577 R:R:M745 10.84292.92NoYes257
75R:R:M745 R:R:R643 20.72927.44YesYes278
76R:R:E642 R:R:R643 15.54366.98YesYes088
77R:R:H748 R:R:N805 13.36535.1YesYes298
78R:R:M745 R:R:N805 10.84724.21YesYes278
79R:R:F627 R:R:F670 11.75244.29YesYes053
80R:R:F790 R:R:V763 11.17882.62YesNo059
81R:R:F760 R:R:V763 10.38453.93YesNo089
82R:R:L62 R:R:L86 10.27624.15YesYes158
83R:R:L110 R:R:L86 10.05544.15YesYes198
84R:R:I610 R:R:Y466 23.58346.04YesYes176
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8WVV
Class A
SubFamily Orphan
Type Orphan
SubType LGR4
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.35
Date 2024-10-30
D.O.I. To be published
Net Summary
Imin 2.77
Number of Linked Nodes 691
Number of Links 913
Number of Hubs 182
Number of Links mediated by Hubs 600
Number of Communities 19
Number of Nodes involved in Communities 247
Number of Links involved in Communities 387
Path Summary
Number Of Nodes in MetaPath 85
Number Of Links MetaPath 84
Number of Shortest Paths 1672152
Length Of Smallest Path 3
Average Path Length 29.2657
Length of Longest Path 56
Minimum Path Strength 1.26
Average Path Strength 5.66366
Maximum Path Strength 25.075
Minimum Path Correlation 0.76
Average Path Correlation 0.99085
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 9.375
Average % Of Corr. Nodes 49.3706
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 66.6964
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• multicellular organismal process   • tissue remodeling   • bone remodeling   • developmental process   • epithelium development   • cell population proliferation   • tube development   • morphogenesis of an epithelium   • tissue development   • renal system development   • epithelial cell proliferation involved in renal tubule morphogenesis   • tissue morphogenesis   • anatomical structure morphogenesis   • multicellular organism development   • tube morphogenesis   • anatomical structure development   • renal tubule development   • cellular process   • epithelial tube morphogenesis   • epithelial cell proliferation   • renal tubule morphogenesis   • system development   • cellular developmental process   • ossification   • cell differentiation   • osteoblast differentiation   • cellular response to stimulus   • positive regulation of response to biotic stimulus   • regulation of cellular process   • pattern recognition receptor signaling pathway   • response to stimulus   • toll-like receptor signaling pathway   • negative regulation of biological process   • regulation of signal transduction   • response to biotic stimulus   • cell communication   • immune response-activating signaling pathway   • positive regulation of immune response   • regulation of immune system process   • signal transduction   • positive regulation of immune system process   • innate immune response-activating signaling pathway   • regulation of biological process   • immune response   • response to other organism   • regulation of innate immune response   • response to external stimulus   • regulation of response to stimulus   • defense response to other organism   • regulation of pattern recognition receptor signaling pathway   • positive regulation of defense response   • activation of innate immune response   • regulation of immune response   • regulation of toll-like receptor signaling pathway   • activation of immune response   • regulation of defense response   • regulation of response to biotic stimulus   • biological process involved in interspecies interaction between organisms   • regulation of response to external stimulus   • signaling   • negative regulation of signaling   • positive regulation of biological process   • negative regulation of cell communication   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • immune response-regulating signaling pathway   • regulation of response to stress   • response to stress   • innate immune response   • negative regulation of cellular process   • response to external biotic stimulus   • regulation of signaling   • positive regulation of innate immune response   • defense response   • negative regulation of response to stimulus   • biological regulation   • defense response to symbiont   • negative regulation of signal transduction   • negative regulation of toll-like receptor signaling pathway   • negative regulation of immune system process   • immune system process   • regulation of cell communication   • spermatogenesis   • sexual reproduction   • reproductive process   • multicellular organismal reproductive process   • developmental process involved in reproduction   • male gamete generation   • gamete generation   • bone mineralization   • animal organ development   • biomineral tissue development   • mesonephric epithelium development   • kidney epithelium development   • branching morphogenesis of an epithelial tube   • nephron tubule morphogenesis   • regulation of kidney development   • regulation of branching involved in ureteric bud morphogenesis   • positive regulation of developmental process   • animal organ morphogenesis   • nephron development   • regulation of morphogenesis of a branching structure   • regulation of animal organ morphogenesis   • positive regulation of multicellular organismal process   • mesonephric tubule development   • regulation of developmental process   • nephron morphogenesis   • nephron epithelium morphogenesis   • nephron tubule development   • ureteric bud morphogenesis   • positive regulation of morphogenesis of an epithelium   • branching involved in ureteric bud morphogenesis   • regulation of morphogenesis of an epithelium   • regulation of multicellular organismal process   • regulation of anatomical structure morphogenesis   • nephron epithelium development   • ureteric bud development   • mesonephros development   • kidney morphogenesis   • morphogenesis of a branching structure   • positive regulation of branching involved in ureteric bud morphogenesis   • mesonephric tubule morphogenesis   • kidney development   • morphogenesis of a branching epithelium   • digestive system development   • digestive tract development   • epidermis development   • molting cycle process   • hair cycle   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • hair cycle process   • genitalia development   • reproductive system development   • sex differentiation   • male sex differentiation   • male genitalia development   • reproductive structure development   • multicellular organismal-level homeostasis   • homeostatic process   • homeostasis of number of cells   • intestinal stem cell homeostasis   • regulation of biosynthetic process   • rhythmic process   • circadian regulation of gene expression   • circadian rhythm   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • regulation of gene expression   • biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • cytokine production   • regulation of cytokine production   • negative regulation of macromolecule metabolic process   • negative regulation of metabolic process   • negative regulation of cytokine production   • negative regulation of gene expression   • negative regulation of biosynthetic process   • negative regulation of macromolecule biosynthetic process   • negative regulation of multicellular organismal process   • metanephric tubule morphogenesis   • metanephric epithelium development   • metanephros development   • metanephros morphogenesis   • metanephric nephron tubule morphogenesis   • metanephric nephron development   • metanephric nephron epithelium development   • metanephric nephron tubule development   • metanephric nephron morphogenesis   • metanephric tubule development   • cell surface receptor signaling pathway   • Wnt signaling pathway   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of canonical Wnt signaling pathway   • canonical Wnt signaling pathway   • positive regulation of Wnt signaling pathway   • positive regulation of cellular process   • positive regulation of canonical Wnt signaling pathway   • regulation of Wnt signaling pathway   • positive regulation of signaling   • negative regulation of cold-induced thermogenesis   • adaptive thermogenesis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • metanephric glomerulus development   • glomerulus development   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .


This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XT9AOrphanOrphanLGR4Homo sapiens---3.12025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XUMAOrphanOrphanLGR4Homo sapiensR-spondin-2--2.92025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XFPAOrphanOrphanLGR4Homo sapiensR-spondin-2-ZNRF33.212024-12-04doi.org/10.1038/s41467-024-55431-3
8XFSAOrphanOrphanLGR4Homo sapiensR-spondin-2-ZNRF33.22024-12-04doi.org/10.1038/s41467-024-55431-3
8XFTAOrphanOrphanLGR4Homo sapiensR-spondin-2-ZNRF33.242024-12-04doi.org/10.1038/s41467-024-55431-3
8Y69AOrphanOrphanLGR4Homo sapiensR-spondin-2-ZNRF33.382024-12-04doi.org/10.1038/s41467-024-55431-3
8WVUAOrphanOrphanLGR4Homo sapiensR-spondin-1-RNF433.612024-10-30To be published
8WVVAOrphanOrphanLGR4Homo sapiens---3.352024-10-30To be published
8WVWAOrphanOrphanLGR4Homo sapiens---3.532024-10-30To be published
8WVXAOrphanOrphanLGR4Homo sapiensNorrin--3.322024-10-30To be published
8WVYAOrphanOrphanLGR4Homo sapiensNorrin--3.292024-10-30To be published
9KGKAOrphanOrphanLGR4Homo sapiens---2.632025-07-16To be published
9KHHAOrphanOrphanLGR4Homo sapiensNorrin--3.652025-07-16To be published
9S37AOrphanOrphanLGR4Homo sapiensNB21--3.942025-07-30To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8WVV.zip



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