psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A31	R:R:P32	1.87	No	No	0	3	3
2	R:R:C33	R:R:P32	1.88	No	No	0	9	3
3	R:R:C33	R:R:C43	7.28	No	No	19	9	8
4	R:R:C33	R:R:K46	6.47	No	Yes	19	9	4
5	R:R:D36	R:R:G37	3.35	Yes	No	0	5	4
6	R:R:D36	R:R:D38	7.98	Yes	No	1	5	6
7	R:R:D36	R:R:R40	11.91	Yes	Yes	1	5	3
8	R:R:D38	R:R:R40	8.34	No	Yes	1	6	3
9	R:R:F58	R:R:R39	3.21	No	No	0	6	7
10	R:R:Q60	R:R:R39	3.5	No	No	0	5	7
11	R:R:D42	R:R:R40	7.15	No	Yes	1	9	3
12	R:R:A61	R:R:R40	4.15	No	Yes	0	4	3
13	R:R:D63	R:R:R40	9.53	Yes	Yes	1	9	3
14	R:R:C43	R:R:V41	1.71	No	No	0	8	7
15	R:R:L55	R:R:V41	2.98	No	No	0	6	7
16	R:R:T59	R:R:V41	4.76	No	No	0	8	7
17	R:R:D42	R:R:S44	2.94	No	Yes	1	9	7
18	R:R:D42	R:R:D63	3.99	No	Yes	1	9	9
19	R:R:C43	R:R:K46	3.23	No	Yes	19	8	4
20	R:R:G45	R:R:S44	3.71	No	Yes	0	8	7
21	R:R:S44	R:R:S65	4.89	Yes	No	1	7	9
22	R:R:M66	R:R:S44	3.07	No	Yes	1	9	7
23	R:R:G47	R:R:K46	1.74	No	Yes	0	7	4
24	R:R:K46	R:R:L48	16.92	Yes	No	0	4	8
25	R:R:G47	R:R:N67	1.7	No	Yes	0	7	9
26	R:R:L48	R:R:P52	4.93	No	Yes	0	8	8
27	R:R:L48	R:R:N67	4.12	No	Yes	0	8	9
28	R:R:P52	R:R:V51	5.3	Yes	No	0	8	5
29	R:R:A76	R:R:V51	1.7	Yes	No	11	4	5
30	R:R:F77	R:R:V51	6.55	Yes	No	11	7	5
31	R:R:L55	R:R:P52	6.57	No	Yes	0	6	8
32	R:R:I64	R:R:P52	3.39	Yes	Yes	0	6	8
33	R:R:F80	R:R:L55	8.53	Yes	No	0	7	6
34	R:R:A57	R:R:P81	1.87	No	No	0	4	5
35	R:R:F58	R:R:F82	5.36	No	No	0	6	5
36	R:R:F80	R:R:T59	3.89	Yes	No	0	7	8
37	R:R:E84	R:R:Q60	3.82	No	No	0	6	5
38	R:R:A61	R:R:E85	3.02	No	Yes	0	4	8
39	R:R:I64	R:R:L62	4.28	Yes	Yes	11	6	5
40	R:R:F77	R:R:L62	2.44	Yes	Yes	11	7	5
41	R:R:F80	R:R:L62	7.31	Yes	Yes	11	7	5
42	R:R:L62	R:R:L83	2.77	Yes	No	11	5	9
43	R:R:D63	R:R:S65	4.42	Yes	No	1	9	9
44	R:R:D63	R:R:Q87	7.83	Yes	Yes	1	9	8
45	R:R:F77	R:R:I64	2.51	Yes	Yes	11	7	6
46	R:R:I64	R:R:L88	2.85	Yes	No	0	6	9
47	R:R:M66	R:R:S65	3.07	No	No	1	9	9
48	R:R:I69	R:R:N67	5.66	No	Yes	20	7	9
49	R:R:N67	R:R:N91	14.98	Yes	No	20	9	9
50	R:R:I69	R:R:N91	5.66	No	No	20	7	9
51	R:R:Q71	R:R:T70	2.83	No	No	0	4	8
52	R:R:A76	R:R:L72	3.15	Yes	No	0	4	7
53	R:R:L72	R:R:L93	2.77	No	No	0	7	9
54	R:R:I96	R:R:L72	2.85	No	No	0	9	7
55	R:R:A76	R:R:P73	1.87	Yes	No	0	4	5
56	R:R:E74	R:R:H97	7.39	No	Yes	21	5	8
57	R:R:E74	R:R:K99	5.4	No	No	21	5	3
58	R:R:D75	R:R:K78	6.91	No	No	0	4	4
59	R:R:D75	R:R:K99	2.77	No	No	0	4	3
60	R:R:A76	R:R:F77	4.16	Yes	Yes	11	4	7
61	R:R:F77	R:R:L86	4.87	Yes	No	0	7	8
62	R:R:F77	R:R:L101	2.44	Yes	No	0	7	7
63	R:R:F77	R:R:L104	3.65	Yes	No	0	7	9
64	R:R:F80	R:R:N79	2.42	Yes	No	0	7	4
65	R:R:F80	R:R:L83	6.09	Yes	No	11	7	9
66	R:R:L104	R:R:L83	5.54	No	No	0	9	9
67	R:R:E106	R:R:E84	6.34	No	No	0	7	6
68	R:R:E84	R:R:K108	8.1	No	No	0	6	8
69	R:R:E85	R:R:Q87	2.55	Yes	Yes	1	8	8
70	R:R:E85	R:R:V109	9.98	Yes	No	0	8	8
71	R:R:E85	R:R:T111	2.82	Yes	Yes	1	8	9
72	R:R:L86	R:R:L88	2.77	No	No	0	8	9
73	R:R:L110	R:R:L86	4.15	No	No	0	9	8
74	R:R:A89	R:R:Q87	3.03	No	Yes	0	9	8
75	R:R:Q87	R:R:T111	14.17	Yes	Yes	1	8	9
76	R:R:L112	R:R:L88	4.15	No	No	0	9	9
77	R:R:A89	R:R:G90	1.95	No	No	0	9	9
78	R:R:A89	R:R:Q113	7.58	No	Yes	0	9	9
79	R:R:G90	R:R:N114	1.7	No	No	0	9	9
80	R:R:G90	R:R:N115	1.7	No	No	0	9	9
81	R:R:L93	R:R:N91	5.49	No	No	0	9	9
82	R:R:D92	R:R:Q116	13.05	No	No	0	5	6
83	R:R:L93	R:R:N115	5.49	No	No	0	9	9
84	R:R:I96	R:R:P121	3.39	No	Yes	0	9	8
85	R:R:H97	R:R:P98	9.15	Yes	No	0	8	4
86	R:R:H97	R:R:K99	5.24	Yes	No	21	8	3
87	R:R:A100	R:R:H97	4.39	No	Yes	0	8	8
88	R:R:L101	R:R:L128	11.07	No	No	0	7	9
89	R:R:G103	R:R:S102	3.71	No	No	0	8	5
90	R:R:G103	R:R:K105	3.49	No	No	0	8	3
91	R:R:L104	R:R:L107	2.77	No	No	0	9	9
92	R:R:E106	R:R:K105	2.7	No	No	0	7	3
93	R:R:L107	R:R:L128	4.15	No	No	22	9	9
94	R:R:L107	R:R:L131	4.15	No	No	22	9	9
95	R:R:K108	R:R:Q132	5.42	No	No	0	8	8
96	R:R:S133	R:R:V109	6.46	No	No	0	9	8
97	R:R:L110	R:R:L112	6.92	No	No	0	9	9
98	R:R:L110	R:R:L134	4.15	No	No	0	9	9
99	R:R:Q113	R:R:T111	9.92	Yes	Yes	1	9	9
100	R:R:R135	R:R:T111	5.17	Yes	Yes	1	9	9
101	R:R:L112	R:R:L136	2.77	No	No	0	9	9
102	R:R:Q113	R:R:R135	15.19	Yes	Yes	1	9	9
103	R:R:D137	R:R:Q113	6.53	Yes	Yes	1	9	9
104	R:R:A138	R:R:N114	3.13	No	No	0	9	9
105	R:R:N115	R:R:N139	4.09	No	Yes	0	9	9
106	R:R:H140	R:R:Q116	7.42	No	No	0	8	6
107	R:R:L117	R:R:P121	3.28	No	Yes	0	8	8
108	R:R:L117	R:R:N139	8.24	No	Yes	0	8	9
109	R:R:K118	R:R:T142	4.5	No	No	0	4	6
110	R:R:P145	R:R:T119	3.5	Yes	No	0	9	5
111	R:R:P121	R:R:V120	1.77	Yes	Yes	0	8	7
112	R:R:S122	R:R:V120	3.23	Yes	Yes	3	5	7
113	R:R:L136	R:R:V120	2.98	No	Yes	0	9	7
114	R:R:I141	R:R:V120	6.14	Yes	Yes	3	9	7
115	R:R:V120	R:R:V144	8.02	Yes	Yes	3	7	9
116	R:R:P145	R:R:V120	3.53	Yes	Yes	3	9	7
117	R:R:S148	R:R:V120	3.23	Yes	Yes	3	8	7
118	R:R:A124	R:R:P121	1.87	No	Yes	0	8	8
119	R:R:I125	R:R:P121	3.39	No	Yes	0	5	8
120	R:R:E123	R:R:S122	4.31	No	Yes	0	5	5
121	R:R:P145	R:R:S122	8.91	Yes	Yes	3	9	5
122	R:R:D147	R:R:S122	2.94	No	Yes	0	3	5
123	R:R:S122	R:R:S148	4.89	Yes	Yes	3	5	8
124	R:R:F149	R:R:I125	2.51	No	No	23	9	5
125	R:R:I125	R:R:L152	2.85	No	No	23	5	8
126	R:R:L128	R:R:L131	5.54	No	No	22	9	9
127	R:R:L131	R:R:L134	2.77	No	No	0	9	9
128	R:R:Q132	R:R:R156	3.5	No	Yes	0	8	9
129	R:R:H157	R:R:S133	8.37	No	No	1	9	9
130	R:R:S133	R:R:W159	2.47	No	Yes	1	9	9
131	R:R:L134	R:R:L136	2.77	No	No	0	9	9
132	R:R:D137	R:R:R135	10.72	Yes	Yes	1	9	9
133	R:R:R135	R:R:W159	18.99	Yes	Yes	1	9	9
134	R:R:A138	R:R:D137	4.63	No	Yes	0	9	9
135	R:R:D137	R:R:W159	2.23	Yes	Yes	1	9	9
136	R:R:D137	R:R:D161	2.66	Yes	No	0	9	9
137	R:R:I141	R:R:N139	4.25	Yes	Yes	3	9	9
138	R:R:N139	R:R:N163	4.09	Yes	Yes	3	9	9
139	R:R:I141	R:R:N163	5.66	Yes	Yes	3	9	9
140	R:R:I141	R:R:L165	2.85	Yes	Yes	3	9	9
141	R:R:S164	R:R:T142	3.2	No	No	0	5	6
142	R:R:P145	R:R:V144	1.77	Yes	Yes	3	9	9
143	R:R:P169	R:R:V144	3.53	No	Yes	3	9	9
144	R:R:P172	R:R:V144	1.77	Yes	Yes	3	9	9
145	R:R:P145	R:R:S148	7.13	Yes	Yes	3	9	8
146	R:R:E146	R:R:H171	16	No	No	3	4	1
147	R:R:E146	R:R:P172	3.14	No	Yes	3	4	9
148	R:R:P172	R:R:S148	1.78	Yes	Yes	3	9	8
149	R:R:F149	R:R:L152	2.44	No	No	23	9	8
150	R:R:F149	R:R:L158	7.31	No	No	0	9	9
151	R:R:E150	R:R:N175	5.26	No	No	0	4	4
152	R:R:G151	R:R:V153	1.84	No	No	0	7	3
153	R:R:L155	R:R:L158	4.15	No	No	0	9	9
154	R:R:L155	R:R:L176	2.77	No	No	0	9	9
155	R:R:H157	R:R:R156	4.51	No	Yes	0	9	9
156	R:R:Q180	R:R:R156	5.84	No	Yes	0	9	9
157	R:R:H157	R:R:W159	4.23	No	Yes	1	9	9
158	R:R:L158	R:R:L182	4.15	No	Yes	0	9	8
159	R:R:T183	R:R:W159	4.85	No	Yes	0	9	9
160	R:R:L160	R:R:L165	5.54	No	Yes	0	9	9
161	R:R:L160	R:R:L184	4.15	No	No	0	9	9
162	R:R:D161	R:R:D162	2.66	No	No	0	9	9
163	R:R:D161	R:R:L186	13.57	No	No	0	9	9
164	R:R:L165	R:R:N163	4.12	Yes	Yes	3	9	9
165	R:R:N163	R:R:N187	4.09	Yes	No	3	9	9
166	R:R:L165	R:R:N187	8.24	Yes	No	3	9	9
167	R:R:P169	R:R:V168	1.77	No	Yes	0	9	8
168	R:R:L184	R:R:V168	2.98	No	Yes	0	9	8
169	R:R:I189	R:R:V168	3.07	No	Yes	0	9	8
170	R:R:P193	R:R:V168	1.77	No	Yes	0	9	8
171	R:R:P169	R:R:P172	5.84	No	Yes	3	9	9
172	R:R:A196	R:R:V170	1.7	No	No	0	9	6
173	R:R:H171	R:R:P172	3.05	No	Yes	3	1	9
174	R:R:H171	R:R:S174	2.79	No	No	0	1	5
175	R:R:F197	R:R:L173	2.44	Yes	No	0	9	9
176	R:R:N175	R:R:S174	5.96	No	No	0	4	5
177	R:R:N199	R:R:S174	2.98	No	No	0	9	5
178	R:R:L176	R:R:L179	5.54	No	No	0	9	9
179	R:R:L179	R:R:L182	6.92	No	Yes	0	9	8
180	R:R:L179	R:R:L200	5.54	No	No	0	9	9
181	R:R:A181	R:R:V205	1.7	No	No	0	9	9
182	R:R:L182	R:R:L184	6.92	Yes	No	0	8	9
183	R:R:L182	R:R:L206	4.15	Yes	No	0	8	9
184	R:R:H207	R:R:T183	5.48	Yes	No	0	9	9
185	R:R:A185	R:R:H209	7.32	No	Yes	0	9	9
186	R:R:H209	R:R:L186	2.57	Yes	No	4	9	9
187	R:R:L186	R:R:N210	6.87	No	No	4	9	9
188	R:R:I189	R:R:N211	9.91	No	Yes	18	9	9
189	R:R:I189	R:R:I213	4.42	No	Yes	18	9	9
190	R:R:K212	R:R:S190	10.71	No	No	0	5	3
191	R:R:S191	R:R:S215	4.89	No	No	0	4	5
192	R:R:I192	R:R:P193	3.39	No	No	0	8	9
193	R:R:I192	R:R:I213	4.42	No	Yes	0	8	9
194	R:R:A196	R:R:P193	3.74	No	No	0	9	9
195	R:R:D194	R:R:F195	3.58	No	No	0	8	2
196	R:R:D194	R:R:S217	5.89	No	No	0	8	6
197	R:R:F195	R:R:T198	2.59	No	No	0	2	4
198	R:R:F195	R:R:H219	2.26	No	No	0	2	5
199	R:R:F197	R:R:L200	2.44	Yes	No	0	9	9
200	R:R:F197	R:R:F221	3.22	Yes	Yes	17	9	9
201	R:R:F197	R:R:L224	6.09	Yes	Yes	17	9	9
202	R:R:N199	R:R:T198	4.39	No	No	0	9	4
203	R:R:L200	R:R:L203	8.3	No	No	0	9	9
204	R:R:L203	R:R:L206	6.92	No	No	0	9	9
205	R:R:L203	R:R:L224	4.15	No	Yes	0	9	9
206	R:R:E228	R:R:V204	7.13	No	No	0	9	9
207	R:R:H207	R:R:V205	6.92	Yes	No	0	9	9
208	R:R:T229	R:R:V205	4.76	No	No	0	9	9
209	R:R:L206	R:R:L230	4.15	No	Yes	0	9	9
210	R:R:H207	R:R:H209	2.39	Yes	Yes	4	9	9
211	R:R:D231	R:R:H207	11.35	No	Yes	4	9	9
212	R:R:I213	R:R:L208	2.85	Yes	No	0	9	9
213	R:R:L208	R:R:L232	2.77	No	No	0	9	9
214	R:R:H209	R:R:N210	7.65	Yes	No	4	9	9
215	R:R:D231	R:R:H209	8.82	No	Yes	4	9	9
216	R:R:H209	R:R:N233	3.83	Yes	Yes	4	9	9
217	R:R:N210	R:R:Y234	9.3	No	Yes	4	9	6
218	R:R:I213	R:R:N211	5.66	Yes	Yes	18	9	9
219	R:R:N211	R:R:N235	4.09	Yes	Yes	18	9	9
220	R:R:I213	R:R:N235	11.33	Yes	Yes	18	9	9
221	R:R:N236	R:R:R214	14.46	No	No	0	5	3
222	R:R:C220	R:R:L216	4.76	Yes	No	17	5	6
223	R:R:F221	R:R:L216	2.44	Yes	No	17	9	6
224	R:R:L216	R:R:P241	3.28	No	No	0	6	9
225	R:R:C220	R:R:S217	3.44	Yes	No	0	5	6
226	R:R:H219	R:R:Q218	3.71	No	No	0	5	3
227	R:R:Q218	R:R:Q242	5.12	No	No	0	3	4
228	R:R:D222	R:R:H219	3.78	No	No	0	4	5
229	R:R:C220	R:R:F221	5.59	Yes	Yes	17	5	9
230	R:R:A243	R:R:C220	1.81	No	Yes	0	8	5
231	R:R:F221	R:R:L224	2.44	Yes	Yes	17	9	9
232	R:R:F221	R:R:L230	3.65	Yes	Yes	0	9	9
233	R:R:A246	R:R:D222	3.09	No	No	0	5	4
234	R:R:L224	R:R:L227	6.92	Yes	No	0	9	9
235	R:R:D225	R:R:P248	3.22	No	No	0	4	4
236	R:R:L227	R:R:L230	4.15	No	Yes	0	9	9
237	R:R:L227	R:R:L247	5.54	No	No	0	9	9
238	R:R:E228	R:R:K251	2.7	No	No	0	9	9
239	R:R:E252	R:R:T229	5.64	No	No	0	9	9
240	R:R:L230	R:R:L232	2.77	Yes	No	0	9	9
241	R:R:L230	R:R:L250	4.15	Yes	Yes	0	9	9
242	R:R:D231	R:R:N233	9.42	No	Yes	4	9	9
243	R:R:N233	R:R:Y234	4.65	Yes	Yes	4	9	6
244	R:R:H256	R:R:N233	11.48	Yes	Yes	4	9	9
245	R:R:H256	R:R:Y234	3.27	Yes	Yes	4	9	6
246	R:R:S257	R:R:Y234	5.09	No	Yes	4	8	6
247	R:R:N235	R:R:N236	4.09	Yes	No	0	9	5
248	R:R:L237	R:R:N235	2.75	No	Yes	0	8	9
249	R:R:L237	R:R:N258	10.98	No	No	0	8	9
250	R:R:E239	R:R:G238	3.27	No	No	0	7	2
251	R:R:F240	R:R:P241	7.22	Yes	No	0	9	9
252	R:R:F240	R:R:I244	2.51	Yes	No	8	9	8
253	R:R:F240	R:R:I260	2.51	Yes	Yes	8	9	9
254	R:R:F240	R:R:P264	10.11	Yes	No	8	9	9
255	R:R:A267	R:R:F240	4.16	No	Yes	8	9	9
256	R:R:F240	R:R:F268	2.14	Yes	Yes	8	9	9
257	R:R:F268	R:R:I244	2.51	Yes	No	8	9	8
258	R:R:I244	R:R:N271	4.25	No	Yes	0	8	9
259	R:R:D269	R:R:K245	2.77	No	No	0	3	5
260	R:R:G270	R:R:K245	1.74	No	No	0	6	5
261	R:R:L247	R:R:L250	5.54	No	Yes	0	9	9
262	R:R:P248	R:R:S249	1.78	No	No	0	4	6
263	R:R:L250	R:R:L253	5.54	Yes	Yes	0	9	9
264	R:R:L250	R:R:N271	4.12	Yes	Yes	0	9	9
265	R:R:K251	R:R:R275	12.38	No	No	0	9	5
266	R:R:E252	R:R:T276	8.47	No	No	4	9	8
267	R:R:E252	R:R:H278	7.39	No	Yes	4	9	8
268	R:R:F255	R:R:L253	4.87	Yes	Yes	0	9	9
269	R:R:F268	R:R:L253	3.65	Yes	Yes	0	9	9
270	R:R:L253	R:R:L274	4.15	Yes	No	0	9	9
271	R:R:G254	R:R:H278	4.77	No	Yes	0	7	8
272	R:R:F255	R:R:I260	2.51	Yes	Yes	8	9	9
273	R:R:F255	R:R:I277	2.51	Yes	Yes	0	9	8
274	R:R:F255	R:R:L279	6.09	Yes	No	0	9	8
275	R:R:F255	R:R:N282	2.42	Yes	Yes	8	9	9
276	R:R:H256	R:R:S257	9.76	Yes	No	4	9	8
277	R:R:H256	R:R:H278	2.39	Yes	Yes	4	9	8
278	R:R:H256	R:R:Y280	29.4	Yes	No	0	9	7
279	R:R:D281	R:R:S257	4.42	No	No	0	8	8
280	R:R:I260	R:R:N258	8.5	Yes	No	8	9	9
281	R:R:N258	R:R:N282	4.09	No	Yes	8	9	9
282	R:R:I260	R:R:N282	2.83	Yes	Yes	8	9	9
283	R:R:S261	R:R:V262	3.23	No	No	0	4	5
284	R:R:S261	R:R:S285	3.26	No	No	0	4	8
285	R:R:I263	R:R:P264	3.39	No	No	0	9	9
286	R:R:I263	R:R:L284	4.28	No	No	0	9	8
287	R:R:A267	R:R:P264	3.74	No	No	8	9	9
288	R:R:D265	R:R:N289	4.04	Yes	No	24	8	4
289	R:R:D265	R:R:S290	4.42	Yes	Yes	24	8	8
290	R:R:D269	R:R:G266	5.03	No	No	0	3	4
291	R:R:F268	R:R:I277	3.77	Yes	Yes	0	9	8
292	R:R:F268	R:R:L295	2.44	Yes	No	0	9	9
293	R:R:G270	R:R:P272	2.03	No	No	0	6	8
294	R:R:L274	R:R:N271	2.75	No	Yes	0	9	9
295	R:R:I277	R:R:L274	2.85	Yes	No	0	8	9
296	R:R:R275	R:R:T276	2.59	No	No	0	5	8
297	R:R:D297	R:R:R275	9.53	No	No	0	5	5
298	R:R:H278	R:R:T276	6.85	Yes	No	4	8	8
299	R:R:I277	R:R:L298	2.85	Yes	No	0	8	9
300	R:R:N282	R:R:P283	4.89	Yes	No	0	9	9
301	R:R:L284	R:R:N282	2.75	No	Yes	0	8	9
302	R:R:F286	R:R:M308	3.73	No	No	0	4	4
303	R:R:F292	R:R:V287	2.62	No	No	0	9	9
304	R:R:A306	R:R:V287	1.7	No	No	2	9	9
305	R:R:V287	R:R:V309	3.21	No	No	2	9	7
306	R:R:A291	R:R:G288	1.95	No	No	0	9	9
307	R:R:N289	R:R:S290	7.45	No	Yes	24	4	8
308	R:R:N314	R:R:S290	2.98	No	Yes	0	7	8
309	R:R:F292	R:R:L301	7.31	No	Yes	0	9	9
310	R:R:H293	R:R:N294	10.2	No	No	0	7	6
311	R:R:G317	R:R:N294	1.7	No	No	0	7	6
312	R:R:L295	R:R:L298	6.92	No	No	0	9	9
313	R:R:D297	R:R:S296	4.42	No	No	0	5	9
314	R:R:L298	R:R:L321	4.15	No	Yes	0	9	8
315	R:R:E322	R:R:H299	13.54	No	No	0	8	7
316	R:R:I303	R:R:L301	2.85	No	Yes	0	8	9
317	R:R:L301	R:R:L321	2.77	Yes	Yes	14	9	8
318	R:R:L301	R:R:L324	2.77	Yes	Yes	14	9	9
319	R:R:R304	R:R:V302	3.92	No	No	6	8	7
320	R:R:T325	R:R:V302	9.52	No	No	6	8	7
321	R:R:I303	R:R:L326	4.28	No	No	0	8	7
322	R:R:R304	R:R:T325	5.17	No	No	6	8	8
323	R:R:R304	R:R:T327	10.35	No	Yes	6	8	9
324	R:R:G305	R:R:G328	2.11	No	No	0	8	7
325	R:R:A306	R:R:V309	3.39	No	No	2	9	7
326	R:R:M308	R:R:S307	4.6	No	No	0	4	7
327	R:R:T329	R:R:V309	4.76	No	No	2	8	7
328	R:R:Q310	R:R:Q311	2.56	No	No	0	5	4
329	R:R:K330	R:R:Q310	6.78	No	No	0	5	5
330	R:R:F312	R:R:P313	5.78	Yes	No	0	8	9
331	R:R:F312	R:R:L326	2.44	Yes	No	0	8	7
332	R:R:F312	R:R:I331	2.51	Yes	No	0	8	8
333	R:R:F312	R:R:P335	20.23	Yes	No	0	8	8
334	R:R:L315	R:R:P313	3.28	No	No	0	9	9
335	R:R:N314	R:R:T316	13.16	No	No	0	7	5
336	R:R:L315	R:R:T318	2.95	No	No	0	9	8
337	R:R:L315	R:R:Q342	5.32	No	No	0	9	8
338	R:R:L321	R:R:T318	2.95	Yes	No	0	8	8
339	R:R:H320	R:R:V319	6.92	No	No	0	7	4
340	R:R:K343	R:R:V319	3.04	No	No	0	7	4
341	R:R:L321	R:R:L324	4.15	Yes	Yes	14	8	9
342	R:R:E322	R:R:R346	3.49	No	No	0	8	7
343	R:R:S323	R:R:T347	4.8	No	No	0	7	6
344	R:R:L324	R:R:L345	4.15	Yes	No	14	9	9
345	R:R:L324	R:R:L348	2.77	Yes	No	14	9	9
346	R:R:D349	R:R:T325	5.78	Yes	No	6	8	8
347	R:R:G328	R:R:T327	3.64	No	Yes	0	7	9
348	R:R:D349	R:R:T327	2.89	Yes	Yes	6	8	9
349	R:R:S351	R:R:T327	3.2	No	Yes	6	9	9
350	R:R:I331	R:R:T329	6.08	No	No	2	8	8
351	R:R:N353	R:R:T329	4.39	Yes	No	2	9	8
352	R:R:I331	R:R:N353	4.25	No	Yes	2	8	9
353	R:R:I334	R:R:P335	3.39	Yes	No	0	7	8
354	R:R:I334	R:R:L338	2.85	Yes	No	0	7	5
355	R:R:I334	R:R:L350	2.85	Yes	No	2	7	9
356	R:R:I334	R:R:I355	7.36	Yes	Yes	2	7	8
357	R:R:I334	R:R:P359	10.16	Yes	No	0	7	9
358	R:R:N336	R:R:N337	2.72	No	No	0	1	3
359	R:R:N336	R:R:P359	4.89	No	No	0	1	9
360	R:R:N337	R:R:Q340	2.64	No	No	0	3	4
361	R:R:C339	R:R:C364	7.28	No	No	0	9	9
362	R:R:E341	R:R:Q342	7.65	No	No	0	5	8
363	R:R:L345	R:R:L348	2.77	No	No	14	9	9
364	R:R:L345	R:R:L367	2.77	No	Yes	14	9	7
365	R:R:E369	R:R:T347	8.47	No	No	0	7	6
366	R:R:L348	R:R:L367	2.77	No	Yes	14	9	7
367	R:R:D349	R:R:S351	4.42	Yes	No	6	8	9
368	R:R:D349	R:R:S371	10.31	Yes	No	0	8	6
369	R:R:I355	R:R:L350	2.85	Yes	No	2	8	9
370	R:R:L350	R:R:L372	4.15	No	No	0	9	8
371	R:R:Q373	R:R:S351	5.78	Yes	No	6	8	9
372	R:R:R374	R:R:Y352	5.14	No	No	0	8	7
373	R:R:I355	R:R:N353	2.83	Yes	Yes	2	8	9
374	R:R:N353	R:R:N375	4.09	Yes	Yes	2	9	9
375	R:R:N354	R:R:Q376	9.24	No	No	0	3	4
376	R:R:I355	R:R:N375	8.5	Yes	Yes	2	8	9
377	R:R:R356	R:R:Y378	4.12	No	No	0	3	1
378	R:R:L358	R:R:P359	3.28	Yes	No	0	8	9
379	R:R:F361	R:R:L358	2.44	No	Yes	0	6	8
380	R:R:L358	R:R:L372	4.15	Yes	No	0	8	8
381	R:R:I377	R:R:L358	11.42	Yes	Yes	0	7	8
382	R:R:L358	R:R:T384	2.95	Yes	Yes	0	8	8
383	R:R:F361	R:R:F385	4.29	No	Yes	0	6	9
384	R:R:F361	R:R:L388	3.65	No	No	0	6	8
385	R:R:G363	R:R:N362	1.7	No	No	0	4	4
386	R:R:G363	R:R:H365	3.18	No	No	0	4	3
387	R:R:C364	R:R:L367	6.35	No	Yes	0	9	7
388	R:R:I370	R:R:L367	5.71	No	Yes	0	7	7
389	R:R:E368	R:R:R392	5.82	No	No	0	7	6
390	R:R:E369	R:R:I393	15.03	No	No	0	7	4
391	R:R:I370	R:R:L391	7.14	No	No	0	7	9
392	R:R:I370	R:R:L394	2.85	No	Yes	0	7	7
393	R:R:Q373	R:R:R374	2.34	Yes	No	0	8	8
394	R:R:D395	R:R:Q373	13.05	No	Yes	6	9	8
395	R:R:Q373	R:R:S397	2.89	Yes	Yes	6	8	8
396	R:R:R374	R:R:R398	8.53	No	No	0	8	5
397	R:R:I377	R:R:N375	2.83	Yes	Yes	2	7	9
398	R:R:N375	R:R:N399	4.09	Yes	Yes	2	9	9
399	R:R:I377	R:R:N399	5.66	Yes	Yes	2	7	9
400	R:R:I377	R:R:I401	2.94	Yes	Yes	2	7	8
401	R:R:Q379	R:R:Y378	10.15	No	No	0	5	1
402	R:R:H402	R:R:Y378	2.18	No	No	0	3	1
403	R:R:K381	R:R:Q379	8.14	No	No	0	1	5
404	R:R:E403	R:R:Q379	5.1	No	No	0	2	5
405	R:R:I380	R:R:T384	3.04	No	Yes	0	7	8
406	R:R:I380	R:R:I401	4.42	No	Yes	2	7	8
407	R:R:I380	R:R:I404	5.89	No	Yes	2	7	7
408	R:R:K381	R:R:T384	3	No	Yes	0	1	8
409	R:R:E382	R:R:G383	3.27	No	No	0	4	4
410	R:R:E382	R:R:H405	12.31	No	No	0	4	6
411	R:R:G383	R:R:Q386	3.29	No	No	0	4	4
412	R:R:F385	R:R:T384	3.89	Yes	Yes	0	9	8
413	R:R:F385	R:R:L394	7.31	Yes	Yes	0	9	7
414	R:R:F385	R:R:L396	2.44	Yes	No	0	9	9
415	R:R:Q386	R:R:T411	4.25	No	No	0	4	4
416	R:R:G387	R:R:T411	1.82	No	No	0	5	4
417	R:R:L388	R:R:L391	5.54	No	No	0	8	9
418	R:R:I389	R:R:S390	3.1	No	No	0	3	5
419	R:R:L391	R:R:L412	2.77	No	No	0	9	8
420	R:R:I393	R:R:N417	4.25	No	No	0	4	7
421	R:R:I415	R:R:L394	2.85	No	Yes	0	7	7
422	R:R:L394	R:R:L418	4.15	Yes	Yes	0	7	9
423	R:R:D395	R:R:S397	4.42	No	Yes	6	9	8
424	R:R:D395	R:R:D419	5.32	No	Yes	6	9	9
425	R:R:I401	R:R:L396	2.85	Yes	No	0	8	9
426	R:R:R398	R:R:S397	2.64	No	Yes	0	5	8
427	R:R:D419	R:R:S397	8.83	Yes	Yes	6	9	8
428	R:R:F422	R:R:R398	14.97	No	No	0	4	5
429	R:R:I401	R:R:N399	5.66	Yes	Yes	2	8	9
430	R:R:N399	R:R:N423	4.09	Yes	Yes	2	9	9
431	R:R:I401	R:R:I404	2.94	Yes	Yes	2	8	7
432	R:R:I401	R:R:N423	5.66	Yes	Yes	2	8	9
433	R:R:E403	R:R:H402	8.62	No	No	0	2	3
434	R:R:I404	R:R:L425	9.99	Yes	Yes	0	7	9
435	R:R:I404	R:R:P429	6.77	Yes	No	0	7	9
436	R:R:A410	R:R:R407	5.53	No	No	25	3	4
437	R:R:E431	R:R:R407	3.49	No	No	25	3	4
438	R:R:A408	R:R:F409	2.77	No	Yes	0	8	8
439	R:R:F409	R:R:L412	4.87	Yes	No	0	8	8
440	R:R:F409	R:R:L418	4.87	Yes	Yes	10	8	9
441	R:R:F409	R:R:P429	2.89	Yes	No	0	8	9
442	R:R:F409	R:R:L433	4.87	Yes	Yes	10	8	9
443	R:R:A410	R:R:E431	4.53	No	No	25	3	3
444	R:R:G413	R:R:L412	1.71	No	No	0	3	8
445	R:R:G413	R:R:P414	4.06	No	No	0	3	5
446	R:R:I415	R:R:L436	4.28	No	Yes	0	7	8
447	R:R:N417	R:R:T416	4.39	No	No	0	7	4
448	R:R:N437	R:R:T416	5.85	No	No	0	5	4
449	R:R:N417	R:R:Q438	9.24	No	No	0	7	9
450	R:R:L418	R:R:L433	2.77	Yes	Yes	10	9	9
451	R:R:L418	R:R:L436	6.92	Yes	Yes	10	9	8
452	R:R:L418	R:R:L439	4.15	Yes	Yes	10	9	8
453	R:R:D419	R:R:S421	4.42	Yes	No	0	9	7
454	R:R:D419	R:R:K440	6.91	Yes	No	0	9	8
455	R:R:N423	R:R:V420	2.96	Yes	No	0	9	6
456	R:R:L425	R:R:V420	2.98	Yes	No	0	9	6
457	R:R:L441	R:R:V420	2.98	No	No	0	8	6
458	R:R:S421	R:R:V442	3.23	No	No	0	7	4
459	R:R:F422	R:R:G443	4.52	No	No	0	4	8
460	R:R:N423	R:R:N444	4.09	Yes	No	0	9	9
461	R:R:E424	R:R:K446	2.7	No	No	0	3	3
462	R:R:F428	R:R:L425	2.44	Yes	Yes	0	4	9
463	R:R:L425	R:R:N444	5.49	Yes	No	0	9	9
464	R:R:K446	R:R:T426	3	No	No	0	3	4
465	R:R:F428	R:R:P429	4.33	Yes	No	0	4	9
466	R:R:F428	R:R:L433	2.44	Yes	Yes	0	4	9
467	R:R:F428	R:R:L441	2.44	Yes	No	0	4	8
468	R:R:D455	R:R:T430	4.34	No	No	10	4	5
469	R:R:F456	R:R:T430	2.59	Yes	No	10	5	5
470	R:R:G432	R:R:N434	1.7	No	No	0	8	3
471	R:R:L433	R:R:L436	8.3	Yes	Yes	10	9	8
472	R:R:G435	R:R:N458	3.39	No	No	0	4	4
473	R:R:L436	R:R:L439	5.54	Yes	Yes	10	8	8
474	R:R:N437	R:R:R460	12.05	No	No	0	5	9
475	R:R:K440	R:R:Q438	4.07	No	No	0	8	9
476	R:R:Q438	R:R:S461	4.33	No	No	0	9	6
477	R:R:L439	R:R:L441	4.15	Yes	No	0	8	8
478	R:R:F456	R:R:L439	3.65	Yes	Yes	10	5	8
479	R:R:L439	R:R:L462	4.15	Yes	Yes	0	8	7
480	R:R:S463	R:R:V442	6.46	No	No	0	8	4
481	R:R:G443	R:R:N444	1.7	No	No	0	8	9
482	R:R:F445	R:R:Y466	2.06	No	Yes	0	1	6
483	R:R:L447	R:R:P465	3.28	No	Yes	0	7	9
484	R:R:K448	R:R:Y466	8.36	No	Yes	7	7	6
485	R:R:I610	R:R:K448	2.91	No	No	7	7	7
486	R:R:K448	R:R:T614	9.01	No	No	7	7	4
487	R:R:F456	R:R:L451	2.44	Yes	No	0	5	7
488	R:R:F473	R:R:L451	3.65	No	No	0	8	7
489	R:R:A453	R:R:F473	2.77	No	No	0	4	8
490	R:R:D455	R:R:K454	11.06	No	No	0	4	5
491	R:R:D455	R:R:F456	2.39	No	Yes	10	4	5
492	R:R:F456	R:R:L459	4.87	Yes	No	0	5	7
493	R:R:L459	R:R:L462	4.15	No	Yes	0	7	7
494	R:R:L462	R:R:V464	5.96	Yes	Yes	0	7	7
495	R:R:F473	R:R:L462	7.31	No	Yes	0	8	7
496	R:R:S463	R:R:T523	3.2	No	No	0	8	6
497	R:R:P465	R:R:V464	5.3	Yes	Yes	7	9	7
498	R:R:Q469	R:R:V464	7.16	Yes	Yes	7	9	7
499	R:R:C470	R:R:V464	3.42	No	Yes	7	9	7
500	R:R:C522	R:R:V464	1.71	No	Yes	7	9	7
501	R:R:P524	R:R:V464	3.53	Yes	Yes	7	9	7
502	R:R:P465	R:R:Y466	2.78	Yes	Yes	7	9	6
503	R:R:P465	R:R:Q469	7.9	Yes	Yes	7	9	9
504	R:R:I610	R:R:Y466	4.84	No	Yes	7	7	6
505	R:R:T614	R:R:Y466	3.75	No	Yes	7	4	6
506	R:R:A467	R:R:P524	1.87	No	Yes	0	9	9
507	R:R:K530	R:R:Y468	8.36	No	Yes	9	8	9
508	R:R:F605	R:R:Y468	5.16	Yes	Yes	9	9	9
509	R:R:G609	R:R:Y468	4.35	No	Yes	9	9	9
510	R:R:E613	R:R:Y468	10.1	No	Yes	9	9	9
511	R:R:P691	R:R:Y468	4.17	Yes	Yes	9	9	9
512	R:R:I610	R:R:Q469	4.12	No	Yes	7	7	9
513	R:R:C470	R:R:C522	7.28	No	No	7	9	9
514	R:R:C470	R:R:P524	3.77	No	Yes	7	9	9
515	R:R:C471	R:R:T526	3.38	No	Yes	26	9	8
516	R:R:C471	R:R:C532	7.28	No	No	26	9	9
517	R:R:G475	R:R:T526	1.82	No	Yes	0	3	8
518	R:R:P524	R:R:T523	3.5	Yes	No	0	9	6
519	R:R:G527	R:R:T526	1.82	No	Yes	0	9	8
520	R:R:C532	R:R:T526	3.38	No	Yes	26	9	8
521	R:R:A528	R:R:E780	4.53	No	No	0	9	8
522	R:R:F529	R:R:P697	2.89	Yes	No	27	8	7
523	R:R:F529	R:R:T698	7.78	Yes	No	27	8	4
524	R:R:F529	R:R:P779	2.89	Yes	No	0	8	8
525	R:R:F529	R:R:K783	11.17	Yes	No	0	8	9
526	R:R:E613	R:R:K530	9.45	No	No	9	9	8
527	R:R:P531	R:R:P691	7.79	No	Yes	0	8	9
528	R:R:E533	R:R:Y534	7.86	No	No	0	4	4
529	R:R:W602	R:R:Y534	6.75	Yes	No	0	4	4
530	R:R:L535	R:R:L536	4.15	Yes	Yes	9	9	5
531	R:R:L535	R:R:L597	2.77	Yes	No	0	9	8
532	R:R:D598	R:R:L535	4.07	No	Yes	9	9	9
533	R:R:L535	R:R:P691	3.28	Yes	Yes	9	9	9
534	R:R:L535	R:R:L692	2.77	Yes	Yes	0	9	7
535	R:R:G537	R:R:L536	1.71	No	Yes	0	6	5
536	R:R:L536	R:R:V545	2.98	Yes	No	0	5	8
537	R:R:D598	R:R:L536	14.93	No	Yes	9	9	5
538	R:R:I541	R:R:S784	6.19	No	No	0	7	7
539	R:R:R542	R:R:W546	2	No	No	0	9	9
540	R:R:D598	R:R:R542	10.72	No	No	0	9	9
541	R:R:R542	R:R:W602	9	No	Yes	0	9	4
542	R:R:I548	R:R:T544	3.04	Yes	No	0	7	9
543	R:R:I788	R:R:T544	3.04	No	No	0	7	9
544	R:R:T595	R:R:V545	3.17	Yes	No	0	7	8
545	R:R:T595	R:R:W546	9.7	Yes	No	0	7	9
546	R:R:F547	R:R:V551	9.18	No	No	0	4	6
547	R:R:I548	R:R:P791	3.39	Yes	No	0	7	9
548	R:R:I548	R:R:L792	2.85	Yes	No	16	7	9
549	R:R:C795	R:R:I548	4.91	No	Yes	16	9	7
550	R:R:F549	R:R:L550	2.44	Yes	No	0	5	3
551	R:R:F549	R:R:L553	3.65	Yes	No	0	5	5
552	R:R:F549	R:R:T591	3.89	Yes	Yes	28	5	7
553	R:R:F549	R:R:G592	9.03	Yes	No	28	5	5
554	R:R:C795	R:R:V551	3.42	No	No	0	9	6
555	R:R:F554	R:R:L553	4.87	No	No	0	3	5
556	R:R:F555	R:R:P798	2.89	Yes	No	0	5	9
557	R:R:F555	R:R:V799	3.93	Yes	No	0	5	9
558	R:R:F555	R:R:V802	2.62	Yes	No	5	5	5
559	R:R:F555	R:R:F803	6.43	Yes	No	5	5	7
560	R:R:N556	R:R:S581	5.96	Yes	Yes	0	9	7
561	R:R:N556	R:R:N584	5.45	Yes	No	0	9	9
562	R:R:L585	R:R:N556	2.75	No	Yes	0	4	9
563	R:R:N556	R:R:P798	11.4	Yes	No	0	9	9
564	R:R:L557	R:R:L585	2.77	No	No	0	3	4
565	R:R:L558	R:R:T562	2.95	No	Yes	5	7	5
566	R:R:F808	R:R:L558	2.44	Yes	No	5	7	7
567	R:R:L558	R:R:W812	2.28	No	Yes	5	7	5
568	R:R:S581	R:R:V559	6.46	Yes	No	0	7	8
569	R:R:P798	R:R:V559	1.77	No	No	0	9	8
570	R:R:V559	R:R:Y801	3.79	No	Yes	0	8	9
571	R:R:I560	R:R:S581	6.19	No	Yes	0	4	7
572	R:R:I560	R:R:V582	4.61	No	No	0	4	3
573	R:R:F808	R:R:T562	6.49	Yes	Yes	5	7	5
574	R:R:T562	R:R:W812	2.43	Yes	Yes	5	5	5
575	R:R:L815	R:R:T562	2.95	No	Yes	5	7	5
576	R:R:F564	R:R:T563	7.78	Yes	No	12	8	4
577	R:R:G578	R:R:T563	1.82	Yes	No	12	8	4
578	R:R:F564	R:R:L570	2.44	Yes	No	0	8	4
579	R:R:F564	R:R:L575	2.44	Yes	No	0	8	6
580	R:R:F564	R:R:G578	3.01	Yes	Yes	12	8	8
581	R:R:L814	R:R:S566	3	No	No	0	4	5
582	R:R:K574	R:R:L570	8.46	No	No	0	7	4
583	R:R:P571	R:R:S573	1.78	No	No	0	7	5
584	R:R:K574	R:R:P571	3.35	No	No	0	7	7
585	R:R:F576	R:R:S572	2.64	Yes	Yes	13	6	6
586	R:R:E642	R:R:S572	4.31	No	Yes	13	8	6
587	R:R:F662	R:R:S572	6.61	Yes	Yes	13	4	6
588	R:R:D811	R:R:K574	5.53	No	No	0	9	7
589	R:R:L575	R:R:L579	2.77	No	Yes	0	6	7
590	R:R:F576	R:R:L635	2.44	Yes	Yes	13	6	5
591	R:R:F576	R:R:L638	2.44	Yes	No	0	6	7
592	R:R:F576	R:R:F662	5.36	Yes	Yes	13	6	4
593	R:R:G578	R:R:I577	1.76	Yes	Yes	12	8	5
594	R:R:I577	R:R:M745	2.92	Yes	No	0	5	7
595	R:R:H748	R:R:I577	5.3	No	Yes	12	9	5
596	R:R:I577	R:R:Y801	6.04	Yes	Yes	12	5	9
597	R:R:G578	R:R:S581	1.86	Yes	Yes	0	8	7
598	R:R:L579	R:R:L635	4.15	Yes	Yes	13	7	5
599	R:R:F670	R:R:L579	9.74	Yes	Yes	13	3	7
600	R:R:F670	R:R:V582	3.93	Yes	No	0	3	3
601	R:R:S583	R:R:S631	6.52	No	No	0	5	5
602	R:R:A632	R:R:S583	3.42	No	No	0	5	5
603	R:R:A794	R:R:N584	6.25	No	No	0	8	9
604	R:R:N584	R:R:N797	4.09	No	Yes	0	9	9
605	R:R:F586	R:R:F627	3.22	No	No	0	6	5
606	R:R:F586	R:R:S628	3.96	No	No	0	6	8
607	R:R:G588	R:R:M587	1.75	No	Yes	0	9	6
608	R:R:M587	R:R:Y590	2.39	Yes	Yes	0	6	5
609	R:R:M587	R:R:S628	4.6	Yes	No	0	6	8
610	R:R:F790	R:R:M587	6.22	Yes	Yes	0	5	6
611	R:R:A794	R:R:M587	3.22	No	Yes	0	8	6
612	R:R:G588	R:R:T591	1.82	No	Yes	0	9	7
613	R:R:L594	R:R:Y590	4.69	No	Yes	0	9	5
614	R:R:A625	R:R:Y590	10.68	No	Yes	0	7	5
615	R:R:L694	R:R:Y590	4.69	No	Yes	0	7	5
616	R:R:G592	R:R:T591	1.82	No	Yes	28	5	7
617	R:R:P791	R:R:T591	1.75	No	Yes	0	9	7
618	R:R:G592	R:R:T595	1.82	No	Yes	0	5	7
619	R:R:L594	R:R:L692	2.77	No	Yes	0	9	7
620	R:R:L597	R:R:W612	9.11	No	Yes	0	8	9
621	R:R:F605	R:R:S601	5.28	Yes	No	0	9	9
622	R:R:F608	R:R:S601	7.93	Yes	No	0	4	9
623	R:R:G603	R:R:W602	4.22	No	Yes	0	9	4
624	R:R:E607	R:R:R604	2.33	No	No	29	1	4
625	R:R:F608	R:R:R604	2.14	Yes	No	29	4	4
626	R:R:F605	R:R:G609	4.52	Yes	No	9	9	9
627	R:R:F605	R:R:P691	2.89	Yes	Yes	9	9	9
628	R:R:E607	R:R:F608	7	No	Yes	29	1	4
629	R:R:G617	R:R:W612	2.81	No	Yes	0	7	9
630	R:R:C618	R:R:W612	3.92	No	Yes	0	9	9
631	R:R:G615	R:R:T614	1.82	No	No	0	7	4
632	R:R:G617	R:R:S616	1.86	No	No	0	7	2
633	R:R:C618	R:R:C693	5.46	No	No	0	9	9
634	R:R:K619	R:R:L681	2.82	No	Yes	0	4	6
635	R:R:A621	R:R:G622	1.95	No	Yes	30	5	8
636	R:R:A621	R:R:C693	3.61	No	No	30	5	9
637	R:R:A625	R:R:G622	1.95	No	Yes	0	7	8
638	R:R:G622	R:R:Y687	4.35	Yes	No	0	8	5
639	R:R:C693	R:R:G622	1.96	No	Yes	30	9	8
640	R:R:F623	R:R:L624	3.65	No	No	0	4	5
641	R:R:F623	R:R:L681	2.44	No	Yes	0	4	6
642	R:R:G677	R:R:V626	1.84	No	No	0	8	6
643	R:R:F706	R:R:V626	2.62	Yes	No	0	5	6
644	R:R:A673	R:R:F627	2.77	No	No	0	8	5
645	R:R:F627	R:R:T674	6.49	No	No	0	5	3
646	R:R:F790	R:R:S629	5.28	Yes	No	0	5	8
647	R:R:E630	R:R:L710	13.25	No	No	0	8	9
648	R:R:E630	R:R:N714	7.89	No	Yes	0	8	9
649	R:R:F670	R:R:S631	5.28	Yes	No	0	3	5
650	R:R:A673	R:R:S631	3.42	No	No	0	8	5
651	R:R:I633	R:R:N714	7.08	No	Yes	0	6	9
652	R:R:F718	R:R:I633	5.02	No	No	0	6	6
653	R:R:F634	R:R:L713	3.65	No	No	0	7	5
654	R:R:A669	R:R:L635	3.15	No	Yes	0	7	5
655	R:R:F670	R:R:L635	4.87	Yes	Yes	13	3	5
656	R:R:L636	R:R:M721	4.24	No	Yes	0	9	7
657	R:R:L636	R:R:L752	4.15	No	No	0	9	9
658	R:R:L636	R:R:N756	4.12	No	Yes	0	9	9
659	R:R:A717	R:R:M637	3.22	No	No	0	9	5
660	R:R:M637	R:R:M721	2.89	No	Yes	0	5	7
661	R:R:A665	R:R:L638	3.15	No	No	0	5	7
662	R:R:M721	R:R:T640	6.02	Yes	No	0	7	7
663	R:R:T640	R:R:Y725	6.24	No	Yes	0	7	8
664	R:R:E642	R:R:R643	4.65	No	No	0	8	8
665	R:R:E642	R:R:F662	4.66	No	Yes	13	8	4
666	R:R:M745	R:R:R643	9.93	No	No	0	7	8
667	R:R:R643	R:R:V749	5.23	No	No	0	8	7
668	R:R:I724	R:R:S644	3.1	Yes	No	0	6	6
669	R:R:H658	R:R:N657	5.1	No	No	0	4	3
670	R:R:F662	R:R:H658	6.79	Yes	No	0	4	4
671	R:R:L659	R:R:R663	7.29	No	No	0	1	4
672	R:R:L667	R:R:L668	2.77	No	No	0	1	2
673	R:R:G672	R:R:V675	3.68	No	No	0	5	3
674	R:R:A676	R:R:G677	1.95	No	No	0	5	8
675	R:R:A676	R:R:F706	2.77	No	Yes	0	5	5
676	R:R:G677	R:R:P680	4.06	No	Yes	0	8	7
677	R:R:C678	R:R:F682	5.59	No	No	0	4	3
678	R:R:F679	R:R:P680	7.22	No	Yes	15	5	7
679	R:R:F679	R:R:H683	2.26	No	No	0	5	4
680	R:R:F679	R:R:F706	7.5	No	Yes	15	5	5
681	R:R:P680	R:R:Y687	18.08	Yes	No	0	7	5
682	R:R:F706	R:R:P680	11.56	Yes	Yes	15	5	7
683	R:R:F682	R:R:L681	3.65	No	Yes	0	3	6
684	R:R:L681	R:R:Y687	4.69	Yes	No	0	6	5
685	R:R:P691	R:R:S690	1.78	Yes	No	0	9	8
686	R:R:P697	R:R:S690	5.34	No	No	0	7	8
687	R:R:K783	R:R:L692	2.82	No	Yes	0	9	7
688	R:R:L692	R:R:L787	11.07	Yes	No	0	7	9
689	R:R:L694	R:R:P695	4.93	No	Yes	0	7	9
690	R:R:F790	R:R:L694	4.87	Yes	No	0	5	7
691	R:R:F696	R:R:P695	10.11	Yes	Yes	15	7	9
692	R:R:F706	R:R:P695	5.78	Yes	Yes	15	5	9
693	R:R:P695	R:R:T707	1.75	Yes	No	15	9	5
694	R:R:F696	R:R:T707	3.89	Yes	No	15	7	5
695	R:R:F696	R:R:V763	3.93	Yes	No	0	7	9
696	R:R:F696	R:R:S767	2.64	Yes	No	0	7	8
697	R:R:F696	R:R:F790	3.22	Yes	Yes	0	7	5
698	R:R:P697	R:R:T698	8.74	No	No	27	7	4
699	R:R:G699	R:R:T698	3.64	No	No	0	4	4
700	R:R:G699	R:R:T707	5.46	No	No	0	4	5
701	R:R:G705	R:R:S703	1.86	No	No	0	6	5
702	R:R:G705	R:R:V708	1.84	No	No	0	6	9
703	R:R:F706	R:R:L710	14.61	Yes	No	0	5	9
704	R:R:S767	R:R:V711	3.23	No	No	0	8	9
705	R:R:F768	R:R:V711	2.62	No	No	0	5	9
706	R:R:F760	R:R:N714	3.62	No	Yes	0	8	9
707	R:R:F718	R:R:M721	2.49	No	Yes	0	6	7
708	R:R:F718	R:R:N756	2.42	No	Yes	0	6	9
709	R:R:L719	R:R:V723	2.98	No	No	0	9	3
710	R:R:I724	R:R:L720	2.85	Yes	No	0	6	5
711	R:R:I753	R:R:M721	7.29	No	Yes	0	9	7
712	R:R:L728	R:R:Y725	3.52	No	Yes	31	9	8
713	R:R:I746	R:R:Y725	4.84	No	Yes	31	7	8
714	R:R:V749	R:R:Y725	7.57	No	Yes	0	7	8
715	R:R:A750	R:R:Y725	4	No	Yes	0	9	8
716	R:R:I746	R:R:L728	4.28	No	No	31	7	9
717	R:R:N740	R:R:Q742	9.24	No	No	0	3	7
718	R:R:P806	R:R:S744	7.13	No	No	0	9	5
719	R:R:K807	R:R:M745	5.76	No	No	0	6	7
720	R:R:H748	R:R:Y801	11.98	No	Yes	12	9	9
721	R:R:H748	R:R:N805	3.83	No	No	12	9	8
722	R:R:L800	R:R:W751	6.83	No	No	5	9	8
723	R:R:F804	R:R:W751	2	No	No	5	9	8
724	R:R:L752	R:R:N797	9.61	No	Yes	0	9	9
725	R:R:F754	R:R:I758	8.79	No	No	0	8	7
726	R:R:F759	R:R:T755	2.59	Yes	No	16	9	7
727	R:R:L796	R:R:T755	5.9	No	No	16	8	7
728	R:R:N756	R:R:P793	3.26	Yes	No	0	9	9
729	R:R:N756	R:R:N797	6.81	Yes	Yes	0	9	9
730	R:R:F759	R:R:I758	2.51	Yes	No	0	9	7
731	R:R:F759	R:R:L792	9.74	Yes	No	16	9	9
732	R:R:F759	R:R:P793	7.22	Yes	No	0	9	9
733	R:R:F759	R:R:L796	2.44	Yes	No	16	9	8
734	R:R:A764	R:R:F760	4.16	No	No	0	9	8
735	R:R:C761	R:R:P762	1.88	No	No	0	7	9
736	R:R:F789	R:R:P762	5.78	No	No	0	7	9
737	R:R:F765	R:R:F766	7.5	No	Yes	0	8	9
738	R:R:F766	R:R:I777	2.51	Yes	Yes	32	9	6
739	R:R:F766	R:R:M782	3.73	Yes	No	32	9	5
740	R:R:F766	R:R:V785	6.55	Yes	No	0	9	7
741	R:R:F768	R:R:L771	3.65	No	No	0	5	7
742	R:R:A769	R:R:P770	1.87	No	No	0	8	9
743	R:R:A769	R:R:M782	3.22	No	No	0	8	5
744	R:R:A774	R:R:I777	6.5	No	Yes	0	8	6
745	R:R:I777	R:R:I781	2.94	Yes	No	0	6	8
746	R:R:I777	R:R:M782	4.37	Yes	No	32	6	5
747	R:R:P779	R:R:S778	3.56	No	No	0	8	6
748	R:R:I781	R:R:S778	6.19	No	No	0	8	6
749	R:R:F789	R:R:I788	3.77	No	No	0	7	7
750	R:R:F790	R:R:P791	4.33	Yes	No	0	5	9
751	R:R:C795	R:R:L792	3.17	No	No	16	9	9
752	R:R:L796	R:R:N797	2.75	No	Yes	0	8	9
753	R:R:F804	R:R:L800	3.65	No	No	5	9	9
754	R:R:N805	R:R:Y801	8.14	No	Yes	12	8	9
755	R:R:F803	R:R:V802	7.87	No	No	5	7	5
756	R:R:F808	R:R:V802	5.24	Yes	No	5	7	5
757	R:R:N805	R:R:P806	4.89	No	No	0	8	9
758	R:R:F808	R:R:W812	2	Yes	Yes	5	7	5
759	R:R:D811	R:R:E810	3.9	No	No	0	9	5
760	R:R:E810	R:R:L814	3.98	No	No	0	5	4
761	R:R:L815	R:R:W812	5.69	No	Yes	5	7	5
762	R:R:K816	R:R:W812	10.44	No	Yes	0	4	5
763	R:R:D265	R:R:G266	1.68	Yes	No	0	8	4
764	R:R:D265	R:R:G288	1.68	Yes	No	0	8	9
765	R:R:E53	R:R:G54	1.64	No	No	0	2	4
766	R:R:L176	R:R:P177	1.64	No	No	0	9	4
767	R:R:L247	R:R:P248	1.64	No	No	0	9	4
768	R:R:N271	R:R:P272	1.63	Yes	No	0	9	8
769	R:R:S285	R:R:S307	1.63	No	No	0	8	7
770	R:R:S300	R:R:S323	1.63	No	No	0	9	7
771	R:R:A100	R:R:I96	1.62	No	No	0	8	9
772	R:R:A632	R:R:I580	1.62	No	No	0	5	7
773	R:R:A467	R:R:K530	1.61	No	No	0	9	8
774	R:R:S56	R:R:T59	1.6	No	No	0	6	8
775	R:R:S94	R:R:T70	1.6	No	No	0	5	8
776	R:R:S143	R:R:T142	1.6	No	No	0	3	6
777	R:R:S202	R:R:T178	1.6	No	No	0	8	5
778	R:R:S427	R:R:T426	1.6	No	No	0	4	4
779	R:R:S776	R:R:T773	1.6	No	No	0	5	5
780	R:R:T709	R:R:V708	1.59	No	No	0	7	9
781	R:R:T786	R:R:V763	1.59	No	No	0	6	9
782	R:R:P73	R:R:Q71	1.58	No	No	0	5	4
783	R:R:A565	R:R:L561	1.58	No	No	0	4	4
784	R:R:A666	R:R:L579	1.58	No	Yes	0	5	7
785	R:R:C35	R:R:D36	1.56	No	Yes	0	9	5
786	R:R:A647	R:R:N731	1.56	No	No	0	4	3
787	R:R:I724	R:R:V641	1.54	Yes	No	0	6	6
788	R:R:K188	R:R:S164	1.53	No	No	0	4	5
789	R:R:K727	R:R:S644	1.53	No	No	0	4	6
790	R:R:A450	R:R:Q469	1.52	No	Yes	0	4	9
791	R:R:I724	R:R:T640	1.52	Yes	No	0	6	7
792	R:R:F286	R:R:G288	1.51	No	No	0	4	9
793	R:R:L659	R:R:S572	1.5	No	Yes	0	1	6
794	R:R:L712	R:R:S715	1.5	No	No	0	8	7
795	R:R:L645	R:R:V641	1.49	No	No	0	2	6
796	R:R:N458	R:R:V457	1.48	No	No	0	4	4
797	R:R:A408	R:R:H405	1.46	No	No	0	8	6
798	R:R:F80	R:R:P81	1.44	Yes	No	0	7	5
799	R:R:F82	R:R:P81	1.44	No	No	0	5	5
800	R:R:E239	R:R:S215	1.44	No	No	0	7	5
801	R:R:E368	R:R:S390	1.44	No	No	0	7	5
802	R:R:E686	R:R:S688	1.44	No	No	0	4	5
803	R:R:E686	R:R:S703	1.44	No	No	0	4	5
804	R:R:E780	R:R:S778	1.44	No	No	0	8	6
805	R:R:E780	R:R:S784	1.44	No	No	0	8	7
806	R:R:I520	R:R:L459	1.43	No	No	0	5	7
807	R:R:I589	R:R:L624	1.43	No	No	0	2	5
808	R:R:E167	R:R:T166	1.41	No	No	0	6	6
809	R:R:K212	R:R:N211	1.4	No	Yes	0	5	9
810	R:R:K212	R:R:N236	1.4	No	No	0	5	5
811	R:R:H293	R:R:S290	1.39	No	Yes	0	7	8
812	R:R:H405	R:R:S406	1.39	No	No	0	6	3
813	R:R:L712	R:R:L716	1.38	No	No	0	8	5
814	R:R:H521	R:R:T523	1.37	No	No	0	8	6
815	R:R:L713	R:R:N714	1.37	No	Yes	0	5	9
816	R:R:L728	R:R:N731	1.37	No	No	0	9	3
817	R:R:K660	R:R:Q661	1.36	No	No	0	1	5
818	R:R:D225	R:R:N226	1.35	No	No	0	4	8
819	R:R:C730	R:R:Y729	1.34	No	No	0	8	9
820	R:R:F95	R:R:S94	1.32	No	No	0	3	5
821	R:R:N289	R:R:Q311	1.32	No	No	0	4	4
822	R:R:N362	R:R:Q340	1.32	No	No	0	4	4
823	R:R:R407	R:R:S406	1.32	No	No	0	4	3
824	R:R:F608	R:R:V600	1.31	Yes	No	0	4	4
825	R:R:F596	R:R:T595	1.3	No	Yes	0	4	7
826	R:R:R156	R:R:T178	1.29	Yes	No	0	9	5
827	R:R:R346	R:R:T347	1.29	No	No	0	7	6
828	R:R:I518	R:R:R460	1.25	No	No	0	4	9
829	R:R:N458	R:R:R460	1.21	No	No	0	4	9
830	R:R:Q376	R:R:R356	1.17	No	No	0	4	3
831	R:R:F803	R:R:F804	1.07	No	No	5	7	9
832	R:R:W539	R:R:W602	0.94	No	Yes	0	9	4
833	R:R:W611	R:R:W612	0.94	No	Yes	0	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:D36	6.2	4	1	5
2	R:R:R40	8.216	5	1	3
3	R:R:S44	3.6525	4	1	7
4	R:R:K46	7.09	4	19	4
5	R:R:P52	5.0475	4	0	8
6	R:R:L62	4.2	4	11	5
7	R:R:D63	6.4425	4	1	9
8	R:R:I64	3.2575	4	11	6
9	R:R:N67	6.615	4	20	9
10	R:R:A76	2.72	4	11	4
11	R:R:F77	3.80286	7	11	7
12	R:R:F80	4.94667	6	11	7
13	R:R:E85	4.5925	4	1	8
14	R:R:Q87	6.895	4	1	8
15	R:R:H97	6.5425	4	21	8
16	R:R:T111	8.02	4	1	9
17	R:R:Q113	9.805	4	1	9
18	R:R:V120	4.12857	7	3	7
19	R:R:P121	2.74	5	0	8
20	R:R:S122	4.856	5	3	5
21	R:R:R135	12.5175	4	1	9
22	R:R:D137	5.354	5	1	9
23	R:R:N139	5.1675	4	3	9
24	R:R:I141	4.725	4	3	9
25	R:R:V144	3.7725	4	3	9
26	R:R:P145	4.968	5	3	9
27	R:R:S148	4.2575	4	3	8
28	R:R:R156	3.785	4	0	9
29	R:R:W159	6.554	5	1	9
30	R:R:N163	4.49	4	3	9
31	R:R:L165	5.1875	4	3	9
32	R:R:V168	2.3975	4	0	8
33	R:R:P172	3.116	5	3	9
34	R:R:L182	5.535	4	0	8
35	R:R:F197	3.5475	4	17	9
36	R:R:H207	6.535	4	4	9
37	R:R:H209	5.43	6	4	9
38	R:R:N211	5.265	4	18	9
39	R:R:I213	5.736	5	18	9
40	R:R:C220	3.9	4	17	5
41	R:R:F221	3.468	5	17	9
42	R:R:L224	4.9	4	17	9
43	R:R:L230	3.774	5	0	9
44	R:R:N233	7.345	4	4	9
45	R:R:Y234	5.5775	4	4	6
46	R:R:N235	5.565	4	18	9
47	R:R:F240	4.775	6	8	9
48	R:R:L250	4.8375	4	0	9
49	R:R:L253	4.5525	4	0	9
50	R:R:F255	3.68	5	8	9
51	R:R:H256	11.26	5	4	9
52	R:R:I260	4.0875	4	8	9
53	R:R:D265	2.955	4	24	8
54	R:R:F268	2.902	5	8	9
55	R:R:N271	3.1875	4	0	9
56	R:R:I277	2.995	4	0	8
57	R:R:H278	5.35	4	4	8
58	R:R:N282	3.396	5	8	9
59	R:R:S290	4.06	4	24	8
60	R:R:L301	3.925	4	14	9
61	R:R:F312	7.74	4	0	8
62	R:R:L321	3.505	4	14	8
63	R:R:L324	3.46	4	14	9
64	R:R:T327	5.02	4	6	9
65	R:R:I334	5.322	5	2	7
66	R:R:D349	5.85	4	6	8
67	R:R:N353	3.89	4	2	9
68	R:R:I355	5.385	4	2	8
69	R:R:L358	4.848	5	0	8
70	R:R:L367	4.4	4	14	7
71	R:R:Q373	6.015	4	6	8
72	R:R:N375	4.8775	4	2	9
73	R:R:I377	5.7125	4	2	7
74	R:R:T384	3.22	4	0	8
75	R:R:F385	4.4825	4	0	9
76	R:R:L394	4.29	4	0	7
77	R:R:S397	4.695	4	6	8
78	R:R:N399	4.875	4	2	9
79	R:R:I401	4.07833	6	2	8
80	R:R:I404	6.3975	4	2	7
81	R:R:F409	4.054	5	10	8
82	R:R:L418	4.572	5	10	9
83	R:R:D419	6.37	4	6	9
84	R:R:N423	4.2	4	2	9
85	R:R:L425	5.225	4	0	9
86	R:R:F428	2.9125	4	0	4
87	R:R:L433	4.595	4	10	9
88	R:R:L436	6.26	4	10	8
89	R:R:L439	4.328	5	10	8
90	R:R:F456	3.188	5	10	5
91	R:R:L462	5.3925	4	0	7
92	R:R:V464	4.51333	6	7	7
93	R:R:P465	4.815	4	7	9
94	R:R:Y466	4.358	5	7	6
95	R:R:Y468	6.428	5	9	9
96	R:R:Q469	5.175	4	7	9
97	R:R:P524	3.1675	4	7	9
98	R:R:T526	2.6	4	26	8
99	R:R:F529	6.1825	4	27	8
100	R:R:L535	3.408	5	9	9
101	R:R:L536	5.9425	4	9	5
102	R:R:I548	3.5475	4	16	7
103	R:R:F549	4.7525	4	28	5
104	R:R:F555	3.9675	4	5	5
105	R:R:N556	6.39	4	0	9
106	R:R:T562	3.705	4	5	5
107	R:R:F564	3.9175	4	12	8
108	R:R:S572	3.765	4	13	6
109	R:R:F576	3.22	4	13	6
110	R:R:I577	4.005	4	12	5
111	R:R:G578	2.1125	4	12	8
112	R:R:L579	4.56	4	13	7
113	R:R:S581	5.1175	4	0	7
114	R:R:M587	3.636	5	0	6
115	R:R:Y590	5.6125	4	0	5
116	R:R:T591	2.32	4	28	7
117	R:R:T595	3.9975	4	0	7
118	R:R:W602	5.2275	4	0	4
119	R:R:F605	4.4625	4	9	9
120	R:R:F608	4.595	4	29	4
121	R:R:W612	4.195	4	0	9
122	R:R:G622	2.5525	4	30	8
123	R:R:L635	3.6525	4	13	5
124	R:R:F662	5.855	4	13	4
125	R:R:F670	5.955	4	13	3
126	R:R:P680	10.23	4	15	7
127	R:R:L681	3.4	4	0	6
128	R:R:P691	3.982	5	9	9
129	R:R:L692	4.8575	4	0	7
130	R:R:P695	5.6425	4	15	9
131	R:R:F696	4.758	5	15	7
132	R:R:F706	7.47333	6	15	5
133	R:R:N714	4.99	4	0	9
134	R:R:M721	4.586	5	0	7
135	R:R:I724	2.2525	4	0	6
136	R:R:Y725	5.234	5	31	8
137	R:R:N756	4.1525	4	0	9
138	R:R:F759	4.9	5	16	9
139	R:R:F766	5.0725	4	32	9
140	R:R:I777	4.08	4	32	6
141	R:R:F790	4.784	5	0	5
142	R:R:N797	5.815	4	0	9
143	R:R:Y801	7.4875	4	12	9
144	R:R:F808	4.0425	4	5	7
145	R:R:W812	4.568	5	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G90	R:R:N115	59.6922	1.7	No	No	0	9	9
2	R:R:A89	R:R:G90	37.8953	1.95	No	No	0	9	9
3	R:R:A89	R:R:Q113	31.1846	7.58	No	Yes	0	9	9
4	R:R:G90	R:R:N114	21.4672	1.7	No	No	0	9	9
5	R:R:I96	R:R:P121	10.7848	3.39	No	Yes	0	9	8
6	R:R:D137	R:R:Q113	20.8155	6.53	Yes	Yes	1	9	9
7	R:R:D137	R:R:W159	18.7527	2.23	Yes	Yes	1	9	9
8	R:R:A138	R:R:N114	21.1324	3.13	No	No	0	9	9
9	R:R:A138	R:R:D137	20.7992	4.63	No	Yes	0	9	9
10	R:R:N115	R:R:N139	65.1081	4.09	No	Yes	0	9	9
11	R:R:I141	R:R:N139	32.8603	4.25	Yes	Yes	3	9	9
12	R:R:I125	R:R:P121	14.0667	3.39	No	Yes	0	5	8
13	R:R:F149	R:R:I125	14.2177	2.51	No	No	23	9	5
14	R:R:H157	R:R:W159	12.0241	4.23	No	Yes	1	9	9
15	R:R:H157	R:R:R156	11.024	4.51	No	Yes	0	9	9
16	R:R:D137	R:R:D161	22.2059	2.66	Yes	No	0	9	9
17	R:R:N139	R:R:N163	32.5357	4.09	Yes	Yes	3	9	9
18	R:R:I141	R:R:L165	35.4963	2.85	Yes	Yes	3	9	9
19	R:R:L165	R:R:N163	32.6897	4.12	Yes	Yes	3	9	9
20	R:R:F149	R:R:L158	14.543	7.31	No	No	0	9	9
21	R:R:L158	R:R:L182	14.85	4.15	No	Yes	0	9	8
22	R:R:L160	R:R:L165	68.5037	5.54	No	Yes	0	9	9
23	R:R:L160	R:R:L184	68.6586	4.15	No	No	0	9	9
24	R:R:L182	R:R:L184	73.8133	6.92	Yes	No	0	8	9
25	R:R:T183	R:R:W159	14.1554	4.85	No	Yes	0	9	9
26	R:R:D161	R:R:L186	20.8596	13.57	No	No	0	9	9
27	R:R:H207	R:R:V205	11.1073	6.92	Yes	No	0	9	9
28	R:R:H207	R:R:T183	13.1471	5.48	Yes	No	0	9	9
29	R:R:L182	R:R:L206	89.227	4.15	Yes	No	0	8	9
30	R:R:H209	R:R:L186	10.0914	2.57	Yes	No	4	9	9
31	R:R:L186	R:R:N210	10.095	6.87	No	No	4	9	9
32	R:R:L206	R:R:L230	89.6805	4.15	No	Yes	0	9	9
33	R:R:R275	R:R:T276	14.1233	2.59	No	No	0	5	8
34	R:R:H256	R:R:H278	12.1109	2.39	Yes	Yes	4	9	8
35	R:R:L230	R:R:L250	91.1147	4.15	Yes	Yes	0	9	9
36	R:R:L250	R:R:L253	73.5566	5.54	Yes	Yes	0	9	9
37	R:R:F268	R:R:L253	36.8181	3.65	Yes	Yes	0	9	9
38	R:R:L250	R:R:N271	18.7942	4.12	Yes	Yes	0	9	9
39	R:R:F255	R:R:L253	18.4657	4.87	Yes	Yes	0	9	9
40	R:R:L253	R:R:L274	18.398	4.15	Yes	No	0	9	9
41	R:R:L274	R:R:N271	19.1845	2.75	No	Yes	0	9	9
42	R:R:F255	R:R:I277	23.8997	2.51	Yes	Yes	0	9	8
43	R:R:F268	R:R:I277	19.2932	3.77	Yes	Yes	0	9	8
44	R:R:I277	R:R:L274	37.5774	2.85	Yes	No	0	8	9
45	R:R:F268	R:R:L295	19.2944	2.44	Yes	No	0	9	9
46	R:R:I277	R:R:L298	80.7331	2.85	Yes	No	0	8	9
47	R:R:L295	R:R:L298	19.3108	6.92	No	No	0	9	9
48	R:R:L298	R:R:L321	100	4.15	No	Yes	0	9	8
49	R:R:L301	R:R:L321	10.3619	2.77	Yes	Yes	14	9	8
50	R:R:N353	R:R:N375	12.4669	4.09	Yes	Yes	2	9	9
51	R:R:N375	R:R:N399	12.0639	4.09	Yes	Yes	2	9	9
52	R:R:N399	R:R:N423	11.8597	4.09	Yes	Yes	2	9	9
53	R:R:N423	R:R:N444	19.1677	4.09	Yes	No	0	9	9
54	R:R:G443	R:R:N444	26.368	1.7	No	No	0	8	9
55	R:R:F422	R:R:G443	25.8058	4.52	No	No	0	4	8
56	R:R:F422	R:R:R398	25.276	14.97	No	No	0	4	5
57	R:R:R398	R:R:S397	17.7743	2.64	No	Yes	0	5	8
58	R:R:D419	R:R:S397	10.9133	8.83	Yes	Yes	6	9	8
59	R:R:D419	R:R:K440	13.2943	6.91	Yes	No	0	9	8
60	R:R:K440	R:R:Q438	12.5951	4.07	No	No	0	8	9
61	R:R:N417	R:R:Q438	11.1964	9.24	No	No	0	7	9
62	R:R:L321	R:R:L324	83.81	4.15	Yes	Yes	14	8	9
63	R:R:L324	R:R:L345	41.9328	4.15	Yes	No	14	9	9
64	R:R:L345	R:R:L367	41.8705	2.77	No	Yes	14	9	7
65	R:R:I370	R:R:L367	83.3259	5.71	No	Yes	0	7	7
66	R:R:I370	R:R:L394	79.9925	2.85	No	Yes	0	7	7
67	R:R:F385	R:R:L394	11.0776	7.31	Yes	Yes	0	9	7
68	R:R:L324	R:R:L348	41.9328	2.77	Yes	No	14	9	9
69	R:R:L348	R:R:L367	41.8705	2.77	No	Yes	14	9	7
70	R:R:L394	R:R:L418	69.2361	4.15	Yes	Yes	0	7	9
71	R:R:L418	R:R:L439	58.8792	4.15	Yes	Yes	10	9	8
72	R:R:L439	R:R:L462	57.7482	4.15	Yes	Yes	0	8	7
73	R:R:L462	R:R:V464	57.0625	5.96	Yes	Yes	0	7	7
74	R:R:P524	R:R:V464	55.0001	3.53	Yes	Yes	7	9	7
75	R:R:Q373	R:R:S351	10.9409	5.78	Yes	No	6	8	9
76	R:R:A467	R:R:P524	51.47	1.87	No	Yes	0	9	9
77	R:R:A467	R:R:K530	51.3202	1.61	No	No	0	9	8
78	R:R:K530	R:R:Y468	51.0124	8.36	No	Yes	9	8	9
79	R:R:P691	R:R:Y468	49.7724	4.17	Yes	Yes	9	9	9
80	R:R:L535	R:R:P691	42.2545	3.28	Yes	Yes	9	9	9
81	R:R:L535	R:R:L692	33.9521	2.77	Yes	Yes	0	9	7
82	R:R:L594	R:R:L692	33.5478	2.77	No	Yes	0	9	7
83	R:R:L594	R:R:Y590	33.3945	4.69	No	Yes	0	9	5
84	R:R:M587	R:R:Y590	25.8653	2.39	Yes	Yes	0	6	5
85	R:R:A794	R:R:M587	19.4505	3.22	No	Yes	0	8	6
86	R:R:A794	R:R:N584	19.2923	6.25	No	No	0	8	9
87	R:R:N584	R:R:N797	10.8034	4.09	No	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8WVW

PDB Summary
PDB	8WVW
Class	A
SubFamily	Orphan
Type	Orphan
SubType	LGR4
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.53
Date	2024-10-30
D.O.I.	To be published

Net Summary
I_min	1.7
Number of Linked Nodes	669
Number of Links	833
Number of Hubs	145
Number of Links mediated by Hubs	495
Number of Communities	32
Number of Nodes involved in Communities	206
Number of Links involved in Communities	271

Path Summary
Number Of Nodes in MetaPath	88
Number Of Links MetaPath	87
Number of Shortest Paths	4270611
Length Of Smallest Path	3
Average Path Length	38.3417
Length of Longest Path	61
Minimum Path Strength	1.23
Average Path Strength	4.41728
Maximum Path Strength	20.44
Minimum Path Correlation	0.73
Average Path Correlation	0.998433
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	7.69231
Average % Of Corr. Nodes	48.1753
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	54.5094
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• multicellular organismal process • tissue remodeling • bone remodeling • developmental process • epithelium development • cell population proliferation • tube development • morphogenesis of an epithelium • tissue development • renal system development • epithelial cell proliferation involved in renal tubule morphogenesis • tissue morphogenesis • anatomical structure morphogenesis • multicellular organism development • tube morphogenesis • anatomical structure development • renal tubule development • cellular process • epithelial tube morphogenesis • epithelial cell proliferation • renal tubule morphogenesis • system development • cellular developmental process • ossification • cell differentiation • osteoblast differentiation • cellular response to stimulus • positive regulation of response to biotic stimulus • regulation of cellular process • pattern recognition receptor signaling pathway • response to stimulus • toll-like receptor signaling pathway • negative regulation of biological process • regulation of signal transduction • response to biotic stimulus • cell communication • immune response-activating signaling pathway • positive regulation of immune response • regulation of immune system process • signal transduction • positive regulation of immune system process • innate immune response-activating signaling pathway • regulation of biological process • immune response • response to other organism • regulation of innate immune response • response to external stimulus • regulation of response to stimulus • defense response to other organism • regulation of pattern recognition receptor signaling pathway • positive regulation of defense response • activation of innate immune response • regulation of immune response • regulation of toll-like receptor signaling pathway • activation of immune response • regulation of defense response • regulation of response to biotic stimulus • biological process involved in interspecies interaction between organisms • regulation of response to external stimulus • signaling • negative regulation of signaling • positive regulation of biological process • negative regulation of cell communication • positive regulation of response to stimulus • positive regulation of response to external stimulus • immune response-regulating signaling pathway • regulation of response to stress • response to stress • innate immune response • negative regulation of cellular process • response to external biotic stimulus • regulation of signaling • positive regulation of innate immune response • defense response • negative regulation of response to stimulus • biological regulation • defense response to symbiont • negative regulation of signal transduction • negative regulation of toll-like receptor signaling pathway • negative regulation of immune system process • immune system process • regulation of cell communication • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • bone mineralization • animal organ development • biomineral tissue development • mesonephric epithelium development • kidney epithelium development • branching morphogenesis of an epithelial tube • nephron tubule morphogenesis • regulation of kidney development • regulation of branching involved in ureteric bud morphogenesis • positive regulation of developmental process • animal organ morphogenesis • nephron development • regulation of morphogenesis of a branching structure • regulation of animal organ morphogenesis • positive regulation of multicellular organismal process • mesonephric tubule development • regulation of developmental process • nephron morphogenesis • nephron epithelium morphogenesis • nephron tubule development • ureteric bud morphogenesis • positive regulation of morphogenesis of an epithelium • branching involved in ureteric bud morphogenesis • regulation of morphogenesis of an epithelium • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • nephron epithelium development • ureteric bud development • mesonephros development • kidney morphogenesis • morphogenesis of a branching structure • positive regulation of branching involved in ureteric bud morphogenesis • mesonephric tubule morphogenesis • kidney development • morphogenesis of a branching epithelium • digestive system development • digestive tract development • epidermis development • molting cycle process • hair cycle • skin development • skin epidermis development • hair follicle development • molting cycle • hair cycle process • genitalia development • reproductive system development • sex differentiation • male sex differentiation • male genitalia development • reproductive structure development • multicellular organismal-level homeostasis • homeostatic process • homeostasis of number of cells • intestinal stem cell homeostasis • regulation of biosynthetic process • rhythmic process • circadian regulation of gene expression • circadian rhythm • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cytokine production • regulation of cytokine production • negative regulation of macromolecule metabolic process • negative regulation of metabolic process • negative regulation of cytokine production • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of multicellular organismal process • metanephric tubule morphogenesis • metanephric epithelium development • metanephros development • metanephros morphogenesis • metanephric nephron tubule morphogenesis • metanephric nephron development • metanephric nephron epithelium development • metanephric nephron tubule development • metanephric nephron morphogenesis • metanephric tubule development • cell surface receptor signaling pathway • Wnt signaling pathway • positive regulation of cell communication • positive regulation of signal transduction • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • positive regulation of Wnt signaling pathway • positive regulation of cellular process • positive regulation of canonical Wnt signaling pathway • regulation of Wnt signaling pathway • positive regulation of signaling • negative regulation of cold-induced thermogenesis • adaptive thermogenesis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • metanephric glomerulus development • glomerulus development • cell periphery • cellular anatomical structure • plasma membrane • membrane
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9BXB1
Sequence	>8WVW_Chain_R A P C S C D G D R R V D C S G K G L T A V P E G L S A F T Q A L D I S M N N I T Q L P E D A F K N F P F L E E L Q L A G N D L S F I H P K A L S G L K E L K V L T L Q N N Q L K T V P S E A I R G L S A L Q S L R L D A N H I T S V P E D S F E G L V Q L R H L W L D D N S L T E V P V H P L S N L P T L Q A L T L A L N K I S S I P D F A F T N L S S L V V L H L H N N K I R S L S Q H C F D G L D N L E T L D L N Y N N L G E F P Q A I K A L P S L K E L G F H S N S I S V I P D G A F D G N P L L R T I H L Y D N P L S F V G N S A F H N L S D L H S L V I R G A S M V Q Q F P N L T G T V H L E S L T L T G T K I S S I P N N L C Q E Q K M L R T L D L S Y N N I R D L P S F N G C H A L E E I S L Q R N Q I Y Q I K E G T F Q G L I S L R I L D L S R N L I H E I H S R A F A T L G P I T N L D V S F N E L T S F P T E G L N G L N Q L K L V G N F K L K E A L A A K D F V N L R S L S V P Y A Y Q C C A F W G S Q I I I H C T P S T G A F K P C E Y L L G S W M I R L T V W F I F L V A L F F N L L V I L T T F A S C L P S S K L F I G L I S V S N L F M G I Y T G I L T F L D A V S W G R F A E F G I W W E T G S G C K V A G F L A V F S S E S A I F L L M L A T V E R S L S A N H L K Q F R V A A L L A F L G A T V A G C F P L F H E Y S A S P L C L P F P T G S L G F T V T L V L L N S L A F L L M A V I Y T K L Y C N N S Q S S M I K H V A W L I F T N C I F F C P V A F F S F A P L I T A I S I S P E I M K S V T L I F F P L P A C L N P V L Y V F F N P K F K E D W K L L K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XUM	A	Orphan	Orphan	LGR4	Homo sapiens	R-spondin-2	-	-	2.9	2025-01-15	To be published
	8XT9	A	Orphan	Orphan	LGR4	Homo sapiens	-	-	-	3.1	2025-01-15	To be published
	8Y69	A	Orphan	Orphan	LGR4	Homo sapiens	R-spondin-2	Cholesterol	ZNRF3	3.38	2024-12-04	To be published
	8XFT	A	Orphan	Orphan	LGR4	Homo sapiens	R-spondin-2	-	ZNRF3	3.24	2024-12-04	To be published
	8XFS	A	Orphan	Orphan	LGR4	Homo sapiens	R-spondin-2	-	ZNRF3	3.2	2024-12-04	To be published
	8XFP	A	Orphan	Orphan	LGR4	Homo sapiens	R-spondin-2	-	ZNRF3	3.21	2024-12-04	To be published
	8WVY	A	Orphan	Orphan	LGR4	Homo sapiens	Norrin	-	-	3.29	2024-10-30	To be published
	8WVW	A	Orphan	Orphan	LGR4	Homo sapiens	-	-	-	3.53	2024-10-30	To be published
	8WVV	A	Orphan	Orphan	LGR4	Homo sapiens	-	-	-	3.35	2024-10-30	To be published
	8WVU	A	Orphan	Orphan	LGR4	Homo sapiens	R-spondin-1	-	RNF43	3.61	2024-10-30	To be published
	8WVX	A	Orphan	Orphan	LGR4	Homo sapiens	Norrin	-	-	3.32	2024-10-30	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8WVW.zip

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