Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 7.855881710
2R:R:M109 7.25403
3R:R:T130 5.728527
4R:R:N134 6.514529
5R:R:Y153 5.775609
6R:R:F155 5.42458
7R:R:L159 4.255409
8R:R:D163 11.035429
9R:R:S173 4.7225414
10R:R:T197 4.77416
11R:R:F200 8.17417
12R:R:A223 1.8375405
13R:R:F237 4.844558
14R:R:I267 9.0375414
15R:R:F268 9.6825415
16R:R:Y275 6.14286717
17R:R:W279 6.0475416
18R:R:Y294 5.098509
19R:R:D338 4.244507
20R:R:I348 3.935468
21R:R:W356 8.54518
22R:R:L387 3.75517
23R:R:N389 6.3425419
24R:R:I396 4.174569
25R:R:Y397 3.91569
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:K192 24.524211.93YesNo106
2R:R:F177 R:R:K192 23.62262.48NoNo046
3R:R:F177 R:R:M109 11.3562.49NoYes043
4L:L:?1 R:R:F268 24.469516.19YesYes105
5R:R:F268 R:R:I267 24.032416.33YesYes154
6R:R:I267 R:R:M371 14.39762.92YesNo141
7R:R:D266 R:R:M371 12.503416.63NoNo041
8R:R:D266 R:R:K376 10.463511.06NoNo042
9L:L:?1 R:R:F200 16.173419.86YesYes107
10R:R:F170 R:R:F200 14.69813.22NoYes177
11L:L:?1 R:R:N389 89.41814.15YesYes109
12R:R:N389 R:R:N393 1006.81YesNo099
13R:R:I396 R:R:N393 87.05952.83YesNo099
14R:R:I396 R:R:Y397 72.68014.84YesYes699
15R:R:I156 R:R:Y397 96.83092.42NoYes089
16R:R:G157 R:R:I156 43.04711.76NoNo068
17R:R:A160 R:R:G157 33.26661.95NoNo096
18R:R:A160 R:R:N134 31.57274.69NoYes099
19R:R:I156 R:R:Y153 74.06434.84NoYes089
20R:R:L404 R:R:Y153 16.619610.55NoYes089
21R:R:R150 R:R:Y153 55.55963.09NoYes059
22R:R:P151 R:R:R150 54.1392.88NoNo055
23R:R:L159 R:R:N393 19.70686.87YesNo099
24R:R:L159 R:R:S206 27.91183YesNo098
25R:R:S158 R:R:S206 26.03594.89NoNo098
26R:R:F237 R:R:S158 24.14176.61YesNo089
27R:R:L159 R:R:L207 17.2484.15YesNo098
28R:R:F177 R:R:H178 11.3564.53NoNo044
29L:L:?1 R:R:Y275 26.78265.67YesYes107
30R:R:P251 R:R:Y275 21.43711.13NoYes167
31R:R:L190 R:R:P251 19.93446.57NoNo056
32R:R:F191 R:R:L190 18.0228.53NoNo055
33R:R:F191 R:R:N187 14.14266.04NoNo051
34R:R:N187 R:R:V188 12.17564.43NoNo015
35R:R:D184 R:R:V188 10.190313.15NoNo025
36R:R:I348 R:R:I396 12.88594.42YesYes689
37R:R:I348 R:R:Y294 15.80914.84YesYes089
38R:R:P151 R:R:V228 52.67281.77NoNo056
39R:R:I227 R:R:V228 51.46163.07NoNo046
40R:R:A223 R:R:I227 49.98631.62YesNo054
41R:R:A223 R:R:R220 43.90312.77YesNo055
42R:R:H219 R:R:R220 40.752220.31NoNo065
43R:R:R214 R:R:Y397 15.56325.14NoYes099
44R:R:H219 R:R:Y296 35.51597.62NoNo864
45R:R:K300 R:R:Y296 34.477710.75NoNo054
46R:R:I218 R:R:K300 31.09015.82NoNo095
47R:R:L345 R:R:Y294 11.64747.03NoYes089
48R:R:A301 R:R:I218 26.11781.62NoNo089
49R:R:A301 R:R:M337 24.36031.61NoNo086
50R:R:A305 R:R:M337 19.20591.61NoNo056
51R:R:A305 R:R:D338 17.36644.63NoYes057
52L:L:?1 R:R:M363 12.82212.56YesNo106
53R:R:I280 R:R:M363 12.12091.46NoNo056
54R:R:L207 R:R:Y397 17.14783.52NoYes089
55R:R:I348 R:R:Y397 10.17213.63YesYes689
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:S173 3.63 1 Yes Yes 0 4 0 1
L:L:?1 R:R:K192 11.93 1 Yes No 0 6 0 1
L:L:?1 R:R:L193 7.52 1 Yes No 0 4 0 1
L:L:?1 R:R:V196 8.1 1 Yes No 0 7 0 1
L:L:?1 R:R:T197 6.23 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F200 19.86 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F268 16.19 1 Yes Yes 0 5 0 1
L:L:?1 R:R:Y275 5.67 1 Yes Yes 0 7 0 1
L:L:?1 R:R:L276 3.34 1 Yes No 0 5 0 1
L:L:?1 R:R:W279 9.63 1 Yes Yes 0 6 0 1
L:L:?1 R:R:W356 15.82 1 Yes Yes 0 8 0 1
L:L:?1 R:R:L359 5.85 1 Yes No 0 7 0 1
L:L:?1 R:R:M363 2.56 1 Yes No 0 6 0 1
L:L:?1 R:R:C386 9.59 1 Yes No 0 7 0 1
L:L:?1 R:R:N389 4.15 1 Yes Yes 0 9 0 1
R:R:F170 R:R:F200 3.22 1 No Yes 7 7 2 1
R:R:K192 R:R:S173 12.24 1 No Yes 6 4 1 1
R:R:F177 R:R:K192 2.48 0 No No 4 6 2 1
R:R:F200 R:R:V196 2.62 1 Yes No 7 7 1 1
R:R:T197 R:R:Y275 3.75 1 Yes Yes 6 7 1 1
R:R:T197 R:R:W279 7.28 1 Yes Yes 6 6 1 1
R:R:C386 R:R:F200 6.98 1 No Yes 7 7 1 1
R:R:T201 R:R:W279 2.43 0 No Yes 6 6 2 1
R:R:V204 R:R:W356 4.9 0 No Yes 7 8 2 1
R:R:I247 R:R:Y275 3.63 0 No Yes 5 7 2 1
R:R:L250 R:R:P251 9.85 1 No No 5 6 2 2
R:R:L250 R:R:Y275 9.38 1 No Yes 5 7 2 1
R:R:P251 R:R:Y275 11.13 1 No Yes 6 7 2 1
R:R:F268 R:R:I267 16.33 1 Yes Yes 5 4 1 2
R:R:F268 R:R:I271 3.77 1 Yes No 5 3 1 2
R:R:F268 R:R:L276 2.44 1 Yes No 5 5 1 1
R:R:I271 R:R:Y275 4.84 0 No Yes 3 7 2 1
R:R:D272 R:R:Y275 4.6 0 No Yes 5 7 2 1
R:R:L276 R:R:M363 5.65 1 No No 5 6 1 1
R:R:T283 R:R:W279 4.85 1 No Yes 8 6 2 1
R:R:L287 R:R:T283 2.95 1 No No 6 8 2 2
R:R:T283 R:R:W356 6.06 1 No Yes 8 8 2 1
R:R:L287 R:R:W356 12.53 1 No Yes 6 8 2 1
R:R:C355 R:R:N389 11.02 0 No Yes 8 9 2 1
R:R:N389 R:R:W356 3.39 1 Yes Yes 9 8 1 1
R:R:C382 R:R:L359 3.17 0 No No 5 7 2 1
R:R:N389 R:R:N393 6.81 1 Yes No 9 9 1 2
R:R:G194 R:R:T197 1.82 0 No Yes 6 6 2 1
L:L:?1 R:R:S383 1.81 1 Yes No 0 6 0 1
L:L:?1 R:R:L360 1.67 1 Yes No 0 7 0 1
R:R:I169 R:R:S173 1.55 0 No Yes 5 4 2 1
R:R:D176 R:R:S173 1.47 0 No Yes 3 4 2 1
R:R:I280 R:R:M363 1.46 0 No No 5 6 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9B54_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.42
Number of Linked Nodes 245
Number of Links 260
Number of Hubs 25
Number of Links mediated by Hubs 107
Number of Communities 9
Number of Nodes involved in Communities 53
Number of Links involved in Communities 68
Path Summary
Number Of Nodes in MetaPath 56
Number Of Links MetaPath 55
Number of Shortest Paths 23202
Length Of Smallest Path 3
Average Path Length 12.1286
Length of Longest Path 34
Minimum Path Strength 1.12
Average Path Strength 5.33428
Maximum Path Strength 17.46
Minimum Path Correlation 0.7
Average Path Correlation 0.923039
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.16667
Average % Of Corr. Nodes 51.5991
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 36.5527
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • neuropeptide signaling pathway   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • neuropeptide signaling pathway   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • cell surface receptor signaling pathway   • response to cytokine   • response to chemokine   • cytokine-mediated signaling pathway   • cellular response to chemokine   • chemokine-mediated signaling pathway   • response to peptide   • cellular response to cytokine stimulus   • multicellular organismal process   • system process   • relaxation of smooth muscle   • regulation of system process   • regulation of muscle system process   • muscle system process   • relaxation of muscle   • positive regulation of relaxation of smooth muscle   • positive regulation of relaxation of muscle   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • regulation of relaxation of smooth muscle   • regulation of relaxation of muscle   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • cell projection   • sperm principal piece   • cilium   • 9+2 motile cilium   • sperm flagellum   • motile cilium   • plasma membrane bounded cell projection   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • ciliary basal body   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • cannabinoid receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • identical protein binding   • cannabinoid signaling pathway   • trans-synaptic signaling   • trans-synaptic signaling by endocannabinoid   • retrograde trans-synaptic signaling   • retrograde trans-synaptic signaling by endocannabinoid   • trans-synaptic signaling by lipid   • retrograde trans-synaptic signaling by lipid   • neuron recognition   • cellular developmental process   • cell projection organization   • cell development   • neuron projection development   • neuron projection fasciculation   • cellular component organization   • neurogenesis   • neuron differentiation   • axonal fasciculation   • cell differentiation   • cell recognition   • cellular component organization or biogenesis   • plasma membrane bounded cell projection organization   • nervous system development   • axon development   • generation of neurons   • neuron development   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • calcium ion homeostasis   • regulation of cytosolic calcium ion concentration   • regulation of presynaptic cytosolic calcium ion concentration   • cellular homeostasis   • neuron cellular homeostasis   • chemical homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • glucose homeostasis   • carbohydrate homeostasis   • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger   • actin cytoskeleton   • mitochondrial membrane   • mitochondrion   • organelle outer membrane   • organelle envelope   • mitochondrial envelope   • mitochondrial outer membrane   • outer membrane   • presynapse   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • membrane microdomain   • membrane raft   • growth cone   • axon   • distal axon   • site of polarized growth   • GABA-ergic synapse   • glutamatergic synapse
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code_L_
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
Code_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP21554
Sequence
>9B54_nogp_Chain_R
FMVLNPSQQ LAIAVLSLT LGTFTVLEN LLVLCVIRC RPSYHFIGS 
LAVADLLGS VIFVYSFID FHVFHRKDS RNVFLFKLG GVTASFTAS 
VGSLFLTAI DRYISIHRP LAYKRIVTR PKAVVAFCL MWTIAIVIA 
VLPLLDIFP HIDETYLMF WIGVTSVLL LFIVYAYMY ILWKAHSHA 
VRMIQRGTA RMDIRLAKT LVLILVVLI ICWGPLLAI MVYDVFGKM 
NKLIKTVFA FCSMLCLLN STVNPIIYA LRSKDLRHA FRSM


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5TGZALipidCannabinoidCB1Homo sapiensAM6538--2.82016-11-02doi.org/10.1016/j.cell.2016.10.004
5U09ALipidCannabinoidCB1Homo sapiensTaranabant--2.62016-12-07doi.org/10.1038/nature20613
5XR8ALipidCannabinoidCB1Homo sapiensAM12033--2.952017-07-12doi.org/10.1038/nature23272
5XRAALipidCannabinoidCB1Homo sapiensAM11542--2.82017-07-12doi.org/10.1038/nature23272
6N4BALipidCannabinoidCB1Homo sapiensMDMB-Fubinaca-Gi1/β1/γ232019-01-30doi.org/10.1016/j.cell.2018.11.040
6N4B (No Gprot) ALipidCannabinoidCB1Homo sapiensMDMB-Fubinaca-32019-01-30doi.org/10.1016/j.cell.2018.11.040
6KQIALipidCannabinoidCB1Homo sapiensCP55940Org27569-3.252019-10-23doi.org/10.1038/s41589-019-0387-2
6KPGALipidCannabinoidCB1Homo sapiensAM841-Gi1/β1/γ232020-02-12doi.org/10.1016/j.cell.2020.01.008
6KPG (No Gprot) ALipidCannabinoidCB1Homo sapiensAM841-32020-02-12doi.org/10.1016/j.cell.2020.01.008
7V3ZALipidCannabinoidCB1Homo sapiensCP55940--3.292021-11-24doi.org/10.1021/jacs.1c06847
7FEEALipidCannabinoidCB1Homo sapiensCP55940ZCZ011-2.72022-06-15doi.org/10.1038/s41589-022-01038-y
7WV9ALipidCannabinoidCB1Homo sapiensCP55940ZCZ011Gi2/β1/γ23.362022-06-15doi.org/10.1038/s41589-022-01038-y
7WV9 (No Gprot) ALipidCannabinoidCB1Homo sapiensCP55940ZCZ0113.362022-06-15doi.org/10.1038/s41589-022-01038-y
8GHVALipidCannabinoidCB1Homo sapiensAMG315-Gi1/β1/γ22.82023-05-24doi.org/10.1038/s41467-023-37864-4
8GHV (No Gprot) ALipidCannabinoidCB1Homo sapiensAMG315-2.82023-05-24doi.org/10.1038/s41467-023-37864-4
8IKGALipidCannabinoidCB1Homo sapiens-PubChem 703205Gi1/β1/γ13.42024-06-05doi.org/10.1073/pnas.2321532121
8IKG (No Gprot) ALipidCannabinoidCB1Homo sapiens-PubChem 7032053.42024-06-05doi.org/10.1073/pnas.2321532121
8IKHALipidCannabinoidCB1Homo sapiens-PubChem 171393541Gi1/β1/γ13.32024-06-05doi.org/10.1073/pnas.2321532121
8IKH (No Gprot) ALipidCannabinoidCB1Homo sapiens-PubChem 1713935413.32024-06-05doi.org/10.1073/pnas.2321532121
9ERXALipidCannabinoidCB1Homo sapiensD9-THC analog-Gi1/β1/γ22.92024-06-26doi.org/10.21203/rs.3.rs-4277209/v1
9ERX (No Gprot) ALipidCannabinoidCB1Homo sapiensD9-THC analog-2.92024-06-26doi.org/10.21203/rs.3.rs-4277209/v1
9B9ZALipidCannabinoidCB1Homo sapiensMRI-1867--3.32024-11-20doi.org/10.1038/s41467-024-54206-0
9BA0ALipidCannabinoidCB1Homo sapiensMRI-1891--3.132024-11-20doi.org/10.1038/s41467-024-54206-0
9B54ALipidCannabinoidCB1Homo sapiensVIP36-Gi1/β1/γ22.862025-03-05doi.org/10.1038/s41586-025-08618-7
9B54 (No Gprot) ALipidCannabinoidCB1Homo sapiensVIP36-2.862025-03-05doi.org/10.1038/s41586-025-08618-7
9B65ALipidCannabinoidCB1Homo sapiensMDMB-Fubinaca-Gi1/β1/γ23.032025-03-05doi.org/10.1038/s41586-025-08618-7
9B65 (No Gprot) ALipidCannabinoidCB1Homo sapiensMDMB-Fubinaca-3.032025-03-05doi.org/10.1038/s41586-025-08618-7
8K8JALipidCannabinoidCB1Homo sapiensFenofibrate-chim(Gs-CtGq)/β1/γ22.882024-02-14doi.org/10.1002/advs.202306311
8K8J (No Gprot) ALipidCannabinoidCB1Homo sapiensFenofibrate-2.882024-02-14doi.org/10.1002/advs.202306311
8GAGALipidCannabinoidCB1Homo sapiensZ8526711350-Gi1/β1/γ23.32024-02-28To be published
8GAG (No Gprot) ALipidCannabinoidCB1Homo sapiensZ8526711350-3.32024-02-28To be published
8WRZALipidCannabinoidCB1Homo sapiensAM841-Arrestin23.62024-02-28AM841
8WU1ALipidCannabinoidCB1Homo sapiensMDMB-Fubinaca-Arrestin23.22024-03-20doi.org/10.1016/j.cell.2023.11.017
9B9YALipidCannabinoidCB1Homo sapiensTaranabant--3.52024-11-20doi.org/10.1038/s41467-024-54206-0
9DGIALipidCannabinoidCB1Homo sapiensZ8526711350--3.352025-04-30doi.org/10.1038/s41467-025-57136-7
9EGOALipidCannabinoidCB1Homo sapiensZ8526711350-Gi1/β1/γ23.22025-04-30doi.org/10.1038/s41467-025-57136-7
9EGO (No Gprot) ALipidCannabinoidCB1Homo sapiensZ8526711350-3.22025-04-30doi.org/10.1038/s41467-025-57136-7




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9B54_nogp.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.