psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:S173	3.28	Yes	Yes	1	0	4
2	L:L:?1	R:R:K192	10.79	Yes	No	1	0	6
3	L:L:?1	R:R:L193	6.81	Yes	No	0	0	4
4	L:L:?1	R:R:V196	7.33	Yes	No	1	0	7
5	L:L:?1	R:R:T197	5.64	Yes	Yes	1	0	6
6	L:L:?1	R:R:F200	17.97	Yes	Yes	1	0	7
7	L:L:?1	R:R:F268	14.64	Yes	Yes	1	0	5
8	L:L:?1	R:R:Y275	5.12	Yes	Yes	1	0	7
9	L:L:?1	R:R:L276	3.03	Yes	No	1	0	5
10	L:L:?1	R:R:W279	8.71	Yes	Yes	1	0	6
11	L:L:?1	R:R:W356	14.31	Yes	Yes	1	0	8
12	L:L:?1	R:R:L359	5.29	Yes	No	0	0	7
13	L:L:?1	R:R:C386	8.67	Yes	No	1	0	7
14	L:L:?1	R:R:N389	3.75	Yes	Yes	1	0	9
15	R:R:F108	R:R:M109	2.49	No	Yes	0	5	3
16	R:R:F177	R:R:M109	2.49	No	Yes	0	4	3
17	R:R:H181	R:R:M109	19.7	No	Yes	0	3	3
18	R:R:K183	R:R:M109	4.32	No	Yes	0	6	3
19	R:R:K373	R:R:V110	6.07	No	No	0	3	3
20	R:R:K376	R:R:V110	7.59	No	No	0	2	3
21	R:R:L111	R:R:Q116	5.32	No	No	0	4	4
22	R:R:H181	R:R:L111	5.14	No	No	0	3	4
23	R:R:N112	R:R:P113	4.89	No	No	3	6	2
24	R:R:N112	R:R:Q115	15.85	No	No	3	6	2
25	R:R:F381	R:R:N112	8.46	No	No	0	4	6
26	R:R:P113	R:R:Q115	3.16	No	No	3	2	2
27	R:R:A120	R:R:L117	3.15	No	No	0	5	5
28	R:R:F381	R:R:I119	7.54	No	No	0	4	5
29	R:R:M384	R:R:S123	3.07	No	No	0	5	7
30	R:R:L126	R:R:T125	2.95	No	No	0	6	4
31	R:R:L126	R:R:L387	2.77	No	Yes	0	6	7
32	R:R:G127	R:R:L387	3.42	No	Yes	0	6	7
33	R:R:E133	R:R:F129	3.5	No	No	2	8	4
34	R:R:F129	R:R:T391	5.19	No	No	2	4	7
35	R:R:N134	R:R:T130	2.92	Yes	Yes	2	9	7
36	R:R:D163	R:R:T130	13.01	Yes	Yes	2	9	7
37	R:R:S167	R:R:T130	4.8	No	Yes	2	7	7
38	R:R:S390	R:R:T130	3.2	No	Yes	2	9	7
39	R:R:T130	R:R:T391	4.71	Yes	No	2	7	7
40	R:R:L164	R:R:V131	2.98	No	No	0	7	6
41	R:R:E133	R:R:T391	2.82	No	No	2	8	7
42	R:R:E133	R:R:P394	9.43	No	No	0	8	9
43	R:R:A160	R:R:N134	4.69	No	Yes	0	9	9
44	R:R:D163	R:R:N134	13.46	Yes	Yes	2	9	9
45	R:R:L164	R:R:N134	8.24	No	Yes	0	7	9
46	R:R:N134	R:R:P394	3.26	Yes	No	0	9	9
47	R:R:L135	R:R:L164	5.54	No	No	0	3	7
48	R:R:A398	R:R:V137	3.39	No	No	0	7	9
49	R:R:C139	R:R:F408	5.59	No	No	0	4	7
50	R:R:L404	R:R:V140	4.47	No	No	0	8	8
51	R:R:F408	R:R:V140	3.93	No	No	0	7	8
52	R:R:L404	R:R:R148	6.07	No	No	0	8	8
53	R:R:H406	R:R:R148	5.64	No	No	4	4	8
54	R:R:A407	R:R:R148	5.53	No	No	4	7	8
55	R:R:P151	R:R:R150	2.88	No	No	0	5	5
56	R:R:R150	R:R:Y153	3.09	No	Yes	0	5	9
57	R:R:S152	R:R:Y153	3.82	No	Yes	0	8	9
58	R:R:I156	R:R:Y153	4.84	No	Yes	0	8	9
59	R:R:S401	R:R:Y153	8.9	No	Yes	0	8	9
60	R:R:D403	R:R:Y153	3.45	No	Yes	0	6	9
61	R:R:L404	R:R:Y153	10.55	No	Yes	0	8	9
62	R:R:F155	R:R:L209	10.96	Yes	No	5	8	6
63	R:R:F155	R:R:T210	2.59	Yes	No	0	8	9
64	R:R:A233	R:R:F155	2.77	No	Yes	0	7	8
65	R:R:F155	R:R:F237	5.36	Yes	Yes	5	8	8
66	R:R:I156	R:R:Y397	2.42	No	Yes	0	8	9
67	R:R:S158	R:R:S206	4.89	No	No	0	9	8
68	R:R:F237	R:R:S158	6.61	Yes	No	0	8	9
69	R:R:L159	R:R:S203	3	Yes	No	0	9	9
70	R:R:L159	R:R:S206	3	Yes	No	0	9	8
71	R:R:L159	R:R:L207	4.15	Yes	No	0	9	8
72	R:R:L159	R:R:N393	6.87	Yes	No	0	9	9
73	R:R:L165	R:R:V161	2.98	No	No	0	6	6
74	R:R:D163	R:R:S167	5.89	Yes	No	2	9	7
75	R:R:D163	R:R:S390	11.78	Yes	No	2	9	9
76	R:R:G166	R:R:S199	3.71	No	No	0	8	7
77	R:R:F170	R:R:F200	3.22	No	Yes	1	7	7
78	R:R:F170	R:R:M384	4.98	No	No	1	7	5
79	R:R:F170	R:R:L387	2.44	No	Yes	1	7	7
80	R:R:L387	R:R:V171	4.47	Yes	No	0	7	7
81	R:R:D176	R:R:Y172	9.2	No	No	0	3	7
82	R:R:K192	R:R:S173	12.24	No	Yes	1	6	4
83	R:R:F174	R:R:I175	3.77	No	No	0	5	5
84	R:R:F174	R:R:H178	14.71	No	No	0	5	4
85	R:R:F177	R:R:H178	4.53	No	No	0	4	4
86	R:R:F177	R:R:K192	2.48	No	No	0	4	6
87	R:R:F180	R:R:V179	9.18	No	No	0	4	4
88	R:R:D184	R:R:V188	13.15	No	No	0	2	5
89	R:R:D184	R:R:F189	13.14	No	No	0	2	9
90	R:R:H270	R:R:R186	3.39	No	No	0	3	3
91	R:R:N187	R:R:V188	4.43	No	No	0	1	5
92	R:R:F191	R:R:N187	6.04	No	No	0	5	1
93	R:R:F189	R:R:H270	6.79	No	No	0	9	3
94	R:R:F191	R:R:L190	8.53	No	No	0	5	5
95	R:R:L190	R:R:P251	6.57	No	No	0	5	6
96	R:R:F191	R:R:L252	2.44	No	No	0	5	5
97	R:R:F200	R:R:V196	2.62	Yes	No	1	7	7
98	R:R:T197	R:R:Y275	3.75	Yes	Yes	1	6	7
99	R:R:T197	R:R:W279	7.28	Yes	Yes	1	6	6
100	R:R:C386	R:R:F200	6.98	No	Yes	1	7	7
101	R:R:T201	R:R:W279	2.43	No	Yes	0	6	6
102	R:R:L286	R:R:V204	4.47	No	No	0	8	7
103	R:R:V204	R:R:W356	4.9	No	Yes	0	7	8
104	R:R:G205	R:R:M240	5.24	No	No	0	5	6
105	R:R:L207	R:R:Y397	3.52	No	Yes	0	8	9
106	R:R:F208	R:R:I212	5.02	No	No	7	7	7
107	R:R:F208	R:R:L286	9.74	No	No	0	7	8
108	R:R:F208	R:R:F289	7.5	No	No	7	7	6
109	R:R:F237	R:R:L209	2.44	Yes	No	5	8	6
110	R:R:L209	R:R:M240	2.83	No	No	0	6	6
111	R:R:A211	R:R:Y294	4	No	Yes	0	8	9
112	R:R:F289	R:R:I212	2.51	No	No	7	6	7
113	R:R:R214	R:R:Y294	7.2	No	Yes	0	9	9
114	R:R:R214	R:R:Y397	5.14	No	Yes	0	9	9
115	R:R:H219	R:R:Y215	5.44	No	No	8	6	8
116	R:R:Y215	R:R:Y292	4.96	No	No	0	8	4
117	R:R:Y215	R:R:Y296	22.84	No	No	8	8	4
118	R:R:I216	R:R:Y224	6.04	No	No	0	5	7
119	R:R:S217	R:R:Y224	6.36	No	No	0	8	7
120	R:R:I218	R:R:I297	4.42	No	No	0	9	9
121	R:R:I218	R:R:K300	5.82	No	No	0	9	5
122	R:R:H219	R:R:R220	20.31	No	No	0	6	5
123	R:R:H219	R:R:Y296	7.62	No	No	8	6	4
124	R:R:A223	R:R:R220	2.77	Yes	No	0	5	5
125	R:R:I227	R:R:V228	3.07	No	No	0	4	6
126	R:R:R230	R:R:T229	2.59	No	No	0	1	8
127	R:R:P231	R:R:T229	8.74	No	No	0	4	8
128	R:R:K232	R:R:V235	4.55	No	No	0	5	3
129	R:R:C238	R:R:F237	2.79	No	Yes	0	4	8
130	R:R:F237	R:R:W241	7.02	Yes	No	0	8	9
131	R:R:I243	R:R:M240	2.92	No	No	0	5	6
132	R:R:I247	R:R:Y275	3.63	No	Yes	0	5	7
133	R:R:L250	R:R:P251	9.85	No	No	1	5	6
134	R:R:L250	R:R:Y275	9.38	No	Yes	1	5	7
135	R:R:P251	R:R:Y275	11.13	No	Yes	1	6	7
136	R:R:D266	R:R:M371	16.63	No	No	0	4	1
137	R:R:D266	R:R:K376	11.06	No	No	0	4	2
138	R:R:F268	R:R:I267	16.33	Yes	Yes	1	5	4
139	R:R:D366	R:R:I267	5.6	No	Yes	1	4	4
140	R:R:I267	R:R:M371	2.92	Yes	No	1	4	1
141	R:R:F379	R:R:I267	11.3	No	Yes	0	4	4
142	R:R:F268	R:R:I271	3.77	Yes	No	0	5	3
143	R:R:F268	R:R:L276	2.44	Yes	No	1	5	5
144	R:R:I271	R:R:Y275	4.84	No	Yes	0	3	7
145	R:R:D272	R:R:Y275	4.6	No	Yes	0	5	7
146	R:R:L276	R:R:M363	5.65	No	No	0	5	6
147	R:R:T283	R:R:W279	4.85	No	Yes	1	8	6
148	R:R:L287	R:R:T283	2.95	No	No	1	6	8
149	R:R:T283	R:R:W356	6.06	No	Yes	1	8	8
150	R:R:L287	R:R:L352	2.77	No	No	0	6	9
151	R:R:L287	R:R:W356	12.53	No	Yes	1	6	8
152	R:R:I290	R:R:Y294	2.42	No	Yes	0	8	9
153	R:R:L349	R:R:V291	4.47	No	No	0	8	5
154	R:R:L345	R:R:Y294	7.03	No	Yes	0	8	9
155	R:R:I348	R:R:Y294	4.84	Yes	Yes	0	8	9
156	R:R:K300	R:R:Y296	10.75	No	No	0	5	4
157	R:R:I297	R:R:L341	2.85	No	No	0	9	8
158	R:R:L298	R:R:L345	4.15	No	No	0	6	8
159	R:R:D338	R:R:H302	6.3	Yes	No	0	7	5
160	R:R:H304	R:R:M308	6.57	No	No	0	7	7
161	R:R:H304	R:R:M337	6.57	No	No	0	7	6
162	R:R:A305	R:R:D338	4.63	No	Yes	0	5	7
163	R:R:I309	R:R:V306	4.61	No	No	0	4	5
164	R:R:A335	R:R:D338	4.63	No	Yes	0	4	7
165	R:R:I339	R:R:R336	13.78	No	No	0	5	4
166	R:R:R336	R:R:R340	7.46	No	No	0	4	7
167	R:R:D338	R:R:I339	4.2	Yes	No	0	7	5
168	R:R:I339	R:R:K343	4.36	No	No	0	5	7
169	R:R:L345	R:R:T344	4.42	No	No	0	8	8
170	R:R:I396	R:R:L347	5.71	Yes	No	0	9	7
171	R:R:L347	R:R:R400	3.64	No	No	0	7	7
172	R:R:I348	R:R:L349	2.85	Yes	No	0	8	8
173	R:R:I348	R:R:I396	4.42	Yes	Yes	6	8	9
174	R:R:I348	R:R:Y397	3.63	Yes	Yes	6	8	9
175	R:R:I354	R:R:V350	3.07	No	No	0	5	6
176	R:R:V351	R:R:V392	6.41	No	No	0	6	6
177	R:R:C355	R:R:N389	11.02	No	Yes	0	8	9
178	R:R:N389	R:R:W356	3.39	Yes	Yes	1	9	8
179	R:R:G357	R:R:P358	4.06	No	No	0	5	9
180	R:R:L385	R:R:P358	3.28	No	No	0	7	9
181	R:R:C382	R:R:L359	3.17	No	No	0	5	7
182	R:R:F379	R:R:I362	6.28	No	No	0	4	4
183	R:R:F368	R:R:V364	7.87	No	No	0	5	6
184	R:R:F368	R:R:Y365	4.13	No	No	9	5	4
185	R:R:G369	R:R:Y365	5.79	No	No	9	3	4
186	R:R:D366	R:R:M371	18.02	No	No	1	4	1
187	R:R:D366	R:R:I375	4.2	No	No	0	4	3
188	R:R:F368	R:R:G369	3.01	No	No	9	5	3
189	R:R:K373	R:R:N372	2.8	No	No	0	3	1
190	R:R:T377	R:R:V378	3.17	No	No	0	1	4
191	R:R:L387	R:R:M384	5.65	Yes	No	1	7	5
192	R:R:N389	R:R:N393	6.81	Yes	No	0	9	9
193	R:R:I396	R:R:V392	3.07	Yes	No	0	9	6
194	R:R:I396	R:R:N393	2.83	Yes	No	0	9	9
195	R:R:I395	R:R:R400	2.51	No	No	0	6	7
196	R:R:I396	R:R:Y397	4.84	Yes	Yes	6	9	9
197	R:R:L399	R:R:R400	9.72	No	No	0	5	7
198	R:R:K402	R:R:R405	4.95	No	No	0	5	8
199	R:R:A407	R:R:H406	2.93	No	No	4	7	4
200	R:R:D213	R:R:R214	2.38	No	No	0	9	9
201	R:R:K300	R:R:W299	2.32	No	No	0	5	3
202	R:R:D213	R:R:Y224	2.3	No	No	0	9	7
203	R:R:G194	R:R:G195	2.11	No	No	0	6	4
204	R:R:A160	R:R:G157	1.95	No	No	0	9	6
205	R:R:A198	R:R:G195	1.95	No	No	0	5	4
206	R:R:G194	R:R:T197	1.82	No	Yes	0	6	6
207	R:R:G312	R:R:T313	1.82	No	No	0	4	3
208	R:R:A162	R:R:A202	1.79	No	No	0	8	7
209	R:R:A198	R:R:A244	1.79	No	No	0	5	8
210	R:R:A211	R:R:A293	1.79	No	No	0	8	7
211	R:R:P394	R:R:V137	1.77	No	No	0	9	9
212	R:R:P151	R:R:V228	1.77	No	No	0	5	6
213	R:R:G157	R:R:I156	1.76	No	No	0	6	8
214	R:R:G157	R:R:L138	1.71	No	No	0	6	7
215	R:R:A162	R:R:S203	1.71	No	No	0	8	9
216	R:R:C238	R:R:V234	1.71	No	No	0	4	1
217	R:R:A118	R:R:V121	1.7	No	No	0	5	4
218	R:R:K232	R:R:P231	1.67	No	No	0	5	4
219	L:L:?1	R:R:S383	1.64	Yes	No	0	0	6
220	R:R:A301	R:R:I218	1.62	No	No	0	8	9
221	R:R:A223	R:R:I227	1.62	Yes	No	0	5	4
222	R:R:A301	R:R:M337	1.61	No	No	0	8	6
223	R:R:A305	R:R:M337	1.61	No	No	0	5	6
224	R:R:A407	R:R:M411	1.61	No	No	0	7	5
225	R:R:V346	R:R:V350	1.6	No	No	0	6	6
226	R:R:T242	R:R:V246	1.59	No	No	0	4	3
227	R:R:C382	R:R:L385	1.59	No	No	0	5	7
228	R:R:A223	R:R:L222	1.58	Yes	No	0	5	7
229	R:R:A342	R:R:L298	1.58	No	No	0	7	6
230	R:R:I169	R:R:S173	1.55	No	Yes	0	5	4
231	R:R:I280	R:R:S284	1.55	No	No	0	5	5
232	R:R:I141	R:R:V140	1.54	No	No	0	7	8
233	R:R:I175	R:R:V179	1.54	No	No	0	5	4
234	R:R:I245	R:R:V249	1.54	No	No	0	4	5
235	R:R:I280	R:R:V364	1.54	No	No	0	5	6
236	R:R:H270	R:R:P269	1.53	No	No	0	3	3
237	R:R:M295	R:R:V291	1.52	No	No	0	3	5
238	L:L:?1	R:R:L360	1.51	Yes	No	0	0	7
239	R:R:L165	R:R:S199	1.5	No	No	0	6	7
240	R:R:L138	R:R:V161	1.49	No	No	0	7	6
241	R:R:L388	R:R:V392	1.49	No	No	0	5	6
242	R:R:D176	R:R:S173	1.47	No	Yes	0	3	4
243	R:R:L239	R:R:T242	1.47	No	No	0	3	4
244	R:R:I353	R:R:I354	1.47	No	No	0	6	5
245	R:R:A233	R:R:H154	1.46	No	No	0	7	3
246	R:R:I280	R:R:M363	1.46	No	No	0	5	6
247	R:R:D338	R:R:V306	1.46	Yes	No	0	7	5
248	R:R:P221	R:R:R220	1.44	No	No	0	8	5
249	R:R:E273	R:R:V367	1.43	No	No	0	3	4
250	R:R:A380	R:R:F381	1.39	No	No	0	4	4
251	R:R:A223	R:R:R226	1.38	Yes	No	0	5	4
252	R:R:D403	R:R:K402	1.38	No	No	0	6	5
253	R:R:L374	R:R:N372	1.37	No	No	0	4	1
254	R:R:F278	R:R:V282	1.31	No	No	0	6	6
255	R:R:F278	R:R:T274	1.3	No	No	0	6	5
256	R:R:K225	R:R:R226	1.24	No	No	0	4	4
257	R:R:Q310	R:R:R311	1.17	No	No	0	4	5
258	R:R:F180	R:R:R182	1.07	No	No	0	4	4
259	R:R:R307	R:R:R311	1.07	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.40562	16	1	0
2	R:R:M109	7.25	4	0	3
3	R:R:T130	5.728	5	2	7
4	R:R:N134	6.514	5	2	9
5	R:R:Y153	5.775	6	0	9
6	R:R:F155	5.42	4	5	8
7	R:R:L159	4.255	4	0	9
8	R:R:D163	11.035	4	2	9
9	R:R:S173	4.635	4	1	4
10	R:R:T197	4.6225	4	1	6
11	R:R:F200	7.6975	4	1	7
12	R:R:A223	1.8375	4	0	5
13	R:R:F237	4.844	5	5	8
14	R:R:I267	9.0375	4	1	4
15	R:R:F268	9.295	4	1	5
16	R:R:Y275	6.06429	7	1	7
17	R:R:W279	5.8175	4	1	6
18	R:R:Y294	5.098	5	0	9
19	R:R:D338	4.244	5	0	7
20	R:R:I348	3.935	4	6	8
21	R:R:W356	8.238	5	1	8
22	R:R:L387	3.75	5	1	7
23	R:R:N389	6.2425	4	1	9
24	R:R:I396	4.174	5	6	9
25	R:R:Y397	3.91	5	6	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:K192	24.5156	10.79	Yes	No	1	0	6
2	R:R:F177	R:R:K192	23.6059	2.48	No	No	0	4	6
3	R:R:F177	R:R:M109	11.3436	2.49	No	Yes	0	4	3
4	L:L:?1	R:R:F268	23.5695	14.64	Yes	Yes	1	0	5
5	R:R:F268	R:R:I267	23.2512	16.33	Yes	Yes	1	5	4
6	R:R:I267	R:R:M371	13.9361	2.92	Yes	No	1	4	1
7	R:R:D266	R:R:M371	12.1077	16.63	No	No	0	4	1
8	R:R:D266	R:R:K376	10.1337	11.06	No	No	0	4	2
9	L:L:?1	R:R:F200	16.1739	17.97	Yes	Yes	1	0	7
10	R:R:F170	R:R:F200	14.6912	3.22	No	Yes	1	7	7
11	L:L:?1	R:R:N389	89.4387	3.75	Yes	Yes	1	0	9
12	R:R:N389	R:R:N393	100	6.81	Yes	No	0	9	9
13	R:R:I396	R:R:N393	87.0736	2.83	Yes	No	0	9	9
14	R:R:I396	R:R:Y397	72.6826	4.84	Yes	Yes	6	9	9
15	R:R:I156	R:R:Y397	96.798	2.42	No	Yes	0	8	9
16	R:R:G157	R:R:I156	43.0001	1.76	No	No	0	6	8
17	R:R:A160	R:R:G157	33.2302	1.95	No	No	0	9	6
18	R:R:A160	R:R:N134	31.5383	4.69	No	Yes	0	9	9
19	R:R:I156	R:R:Y153	74.0562	4.84	No	Yes	0	8	9
20	R:R:L404	R:R:Y153	16.6288	10.55	No	Yes	0	8	9
21	R:R:R150	R:R:Y153	55.5353	3.09	No	Yes	0	5	9
22	R:R:P151	R:R:R150	54.1163	2.88	No	No	0	5	5
23	R:R:L159	R:R:N393	19.6853	6.87	Yes	No	0	9	9
24	R:R:L159	R:R:S206	27.8814	3	Yes	No	0	9	8
25	R:R:S158	R:R:S206	26.0075	4.89	No	No	0	9	8
26	R:R:F237	R:R:S158	24.1153	6.61	Yes	No	0	8	9
27	R:R:L159	R:R:L207	17.2291	4.15	Yes	No	0	9	8
28	R:R:F177	R:R:H178	11.3436	4.53	No	No	0	4	4
29	L:L:?1	R:R:Y275	26.7261	5.12	Yes	Yes	1	0	7
30	R:R:P251	R:R:Y275	21.4227	11.13	No	Yes	1	6	7
31	R:R:L190	R:R:P251	19.9127	6.57	No	No	0	5	6
32	R:R:F191	R:R:L190	18.0024	8.53	No	No	0	5	5
33	R:R:F191	R:R:N187	14.1272	6.04	No	No	0	5	1
34	R:R:N187	R:R:V188	12.1623	4.43	No	No	0	1	5
35	R:R:D184	R:R:V188	10.1792	13.15	No	No	0	2	5
36	R:R:I348	R:R:I396	12.89	4.42	Yes	Yes	6	8	9
37	R:R:I348	R:R:Y294	15.801	4.84	Yes	Yes	0	8	9
38	R:R:P151	R:R:V228	52.6517	1.77	No	No	0	5	6
39	R:R:I227	R:R:V228	51.4327	3.07	No	No	0	4	6
40	R:R:A223	R:R:I227	49.9591	1.62	Yes	No	0	5	4
41	R:R:A223	R:R:R220	43.8825	2.77	Yes	No	0	5	5
42	R:R:H219	R:R:R220	40.735	20.31	No	No	0	6	5
43	R:R:R214	R:R:Y397	15.5554	5.14	No	Yes	0	9	9
44	R:R:H219	R:R:Y296	35.5044	7.62	No	No	8	6	4
45	R:R:K300	R:R:Y296	34.4583	10.75	No	No	0	5	4
46	R:R:I218	R:R:K300	31.0743	5.82	No	No	0	9	5
47	L:L:?1	R:R:L276	13.645	3.03	Yes	No	1	0	5
48	R:R:L276	R:R:M363	13.1083	5.65	No	No	0	5	6
49	R:R:L345	R:R:Y294	11.6347	7.03	No	Yes	0	8	9
50	R:R:A301	R:R:I218	26.0984	1.62	No	No	0	8	9
51	R:R:A301	R:R:M337	24.3428	1.61	No	No	0	8	6
52	R:R:A305	R:R:M337	19.1849	1.61	No	No	0	5	6
53	R:R:A305	R:R:D338	17.3474	4.63	No	Yes	0	5	7
54	R:R:I280	R:R:M363	11.289	1.46	No	No	0	5	6
55	R:R:L207	R:R:Y397	17.1291	3.52	No	Yes	0	8	9
56	R:R:I348	R:R:Y397	10.161	3.63	Yes	Yes	6	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:S173	3.28	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:K192	10.79	1	Yes	No	0	6	0	1
L:L:?1	R:R:L193	6.81	1	Yes	No	0	4	0	1
L:L:?1	R:R:V196	7.33	1	Yes	No	0	7	0	1
L:L:?1	R:R:T197	5.64	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F200	17.97	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F268	14.64	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y275	5.12	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:L276	3.03	1	Yes	No	0	5	0	1
L:L:?1	R:R:W279	8.71	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:W356	14.31	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:L359	5.29	1	Yes	No	0	7	0	1
L:L:?1	R:R:C386	8.67	1	Yes	No	0	7	0	1
L:L:?1	R:R:N389	3.75	1	Yes	Yes	0	9	0	1
R:R:F170	R:R:F200	3.22	1	No	Yes	7	7	2	1
R:R:K192	R:R:S173	12.24	1	No	Yes	6	4	1	1
R:R:F177	R:R:K192	2.48	0	No	No	4	6	2	1
R:R:F200	R:R:V196	2.62	1	Yes	No	7	7	1	1
R:R:T197	R:R:Y275	3.75	1	Yes	Yes	6	7	1	1
R:R:T197	R:R:W279	7.28	1	Yes	Yes	6	6	1	1
R:R:C386	R:R:F200	6.98	1	No	Yes	7	7	1	1
R:R:T201	R:R:W279	2.43	0	No	Yes	6	6	2	1
R:R:V204	R:R:W356	4.9	0	No	Yes	7	8	2	1
R:R:I247	R:R:Y275	3.63	0	No	Yes	5	7	2	1
R:R:L250	R:R:P251	9.85	1	No	No	5	6	2	2
R:R:L250	R:R:Y275	9.38	1	No	Yes	5	7	2	1
R:R:P251	R:R:Y275	11.13	1	No	Yes	6	7	2	1
R:R:F268	R:R:I267	16.33	1	Yes	Yes	5	4	1	2
R:R:F268	R:R:I271	3.77	1	Yes	No	5	3	1	2
R:R:F268	R:R:L276	2.44	1	Yes	No	5	5	1	1
R:R:I271	R:R:Y275	4.84	0	No	Yes	3	7	2	1
R:R:D272	R:R:Y275	4.6	0	No	Yes	5	7	2	1
R:R:L276	R:R:M363	5.65	1	No	No	5	6	1	2
R:R:T283	R:R:W279	4.85	1	No	Yes	8	6	2	1
R:R:L287	R:R:T283	2.95	1	No	No	6	8	2	2
R:R:T283	R:R:W356	6.06	1	No	Yes	8	8	2	1
R:R:L287	R:R:W356	12.53	1	No	Yes	6	8	2	1
R:R:C355	R:R:N389	11.02	0	No	Yes	8	9	2	1
R:R:N389	R:R:W356	3.39	1	Yes	Yes	9	8	1	1
R:R:C382	R:R:L359	3.17	0	No	No	5	7	2	1
R:R:N389	R:R:N393	6.81	1	Yes	No	9	9	1	2
R:R:G194	R:R:T197	1.82	0	No	Yes	6	6	2	1
L:L:?1	R:R:S383	1.64	1	Yes	No	0	6	0	1
R:R:I169	R:R:S173	1.55	0	No	Yes	5	4	2	1
L:L:?1	R:R:L360	1.51	1	Yes	No	0	7	0	1
R:R:D176	R:R:S173	1.47	0	No	Yes	3	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9B54_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.42
Number of Linked Nodes	245
Number of Links	259
Number of Hubs	25
Number of Links mediated by Hubs	106
Number of Communities	9
Number of Nodes involved in Communities	52
Number of Links involved in Communities	66

Path Summary
Number Of Nodes in MetaPath	57
Number Of Links MetaPath	56
Number of Shortest Paths	23131
Length Of Smallest Path	3
Average Path Length	12.194
Length of Longest Path	34
Minimum Path Strength	1.12
Average Path Strength	5.2426
Maximum Path Strength	17.325
Minimum Path Correlation	0.7
Average Path Correlation	0.922831
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	51.5168
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.3961
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1A
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1A
Name	6-AMINO HEXANOIC ACID
Synonyms
Identifier
Formula	C33 H40 N4 O6
Molecular Weight	588.694
SMILES
PubChem	5327090
Formal Charge	0
Total Atoms	83
Total Chiral Atoms	4
Total Bonds	86
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21554
Sequence	>9B54_nogp_Chain_R F M V L N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I R C R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V F H R K D S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R P L A Y K R I V T R P K A V V A F C L M W T I A I V I A V L P L L D I F P H I D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G T A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G K M N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D L R H A F R S M Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7FEE	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	-	2.7	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	7WV9	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	Gi2/β1/γ2	3.36	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	7WV9 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011		3.36	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	8IKH	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2L	Gi1/β1/γ1	3.3	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKH (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2L		3.3	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2B	Gi1/β1/γ1	3.4	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2B		3.4	2024-06-05	doi.org/10.1073/pnas.2321532121
	6KQI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	Org27569	-	3.25	2019-10-23	doi.org/10.1038/s41589-019-0387-2
	8K8J	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-	chim(Gs-CtGq)/β1/γ2	2.88	2024-02-14	doi.org/10.1002/advs.202306311
	8K8J (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-		2.88	2024-02-14	doi.org/10.1002/advs.202306311
	5TGZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM6538	-	-	2.8	2016-11-02	doi.org/10.1016/j.cell.2016.10.004
	6N4B	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-	Gi1/β1/γ2	3	2019-01-30	doi.org/10.1016/j.cell.2018.11.040
	6N4B (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-		3	2019-01-30	doi.org/10.1016/j.cell.2018.11.040
	6KPG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	Gi1/β1/γ2	3	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-		3	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	7V3Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	-	-	3.29	2021-11-24	doi.org/10.1021/jacs.1c06847
	5U09	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Taranabant	-	-	2.6	2016-12-07	doi.org/10.1038/nature20613
	5XR8	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	-	2.95	2017-07-12	doi.org/10.1038/nature23272
	5XRA	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM11542	-	-	2.8	2017-07-12	doi.org/10.1038/nature23272
	8GHV	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-	Gi1/β1/γ2	2.8	2023-05-24	doi.org/10.1038/s41467-023-37864-4
	8GHV (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-		2.8	2023-05-24	doi.org/10.1038/s41467-023-37864-4
	9B9Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKO	-	-	3.3	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9BA0	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKN	-	-	3.13	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9B9Y	A	Lipid	Cannabinoid	CB₁	Homo sapiens	7DY	-	-	3.5	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9B54	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-	Gi1/β1/γ2	2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B54 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-		2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B65	A	Lipid	Cannabinoid	CB₁	Homo sapiens	KCA	-	Gi1/β1/γ2	3.03	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B65 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	KCA	-		3.03	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	8WRZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 102336704	-	Arrestin2	3.6	2024-02-28	doi.org/10.1093/procel/pwad055
	9ERX	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-	Gi1/β1/γ2	2.9	2024-06-26	doi.org/10.21203/rs.3.rs-4277209/v1
	9ERX (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-		2.9	2024-06-26	doi.org/10.21203/rs.3.rs-4277209/v1
	8WU1	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 119025665	-	Arrestin2	3.2	2024-03-20	doi.org/10.1016/j.cell.2023.11.017
	9DGI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Z8526711350	-	-	3.35	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	9EGO	A	Lipid	Cannabinoid	CB₁	Homo sapiens	YVF	-	Gi1/β1/γ2	3.2	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	9EGO (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	YVF	-		3.2	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	8GAG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 170838490	-	Gi1/β1/γ2	3.3	2024-02-28	To be published
	8GAG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 170838490	-		3.3	2024-02-28	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9B54_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.