psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F170	7.89	Yes	Yes	1	0	7
2	L:L:?1	R:R:F174	2.63	Yes	Yes	1	0	5
3	L:L:?1	R:R:F189	3.51	Yes	Yes	1	0	9
4	L:L:?1	R:R:L193	13.94	Yes	Yes	1	0	4
5	L:L:?1	R:R:V196	17.15	Yes	No	1	0	7
6	L:L:?1	R:R:T197	7.43	Yes	No	0	0	6
7	L:L:?1	R:R:F200	13.15	Yes	Yes	1	0	7
8	L:L:?1	R:R:P269	7.09	Yes	No	0	0	3
9	L:L:?1	R:R:Y275	5.91	Yes	Yes	0	0	7
10	L:L:?1	R:R:L276	3.98	Yes	No	1	0	5
11	L:L:?1	R:R:W279	6.56	Yes	Yes	1	0	6
12	L:L:?1	R:R:M363	3.05	Yes	Yes	1	0	6
13	L:L:?1	R:R:S383	5.4	Yes	Yes	1	0	6
14	R:R:F108	R:R:V110	3.93	No	No	0	5	3
15	R:R:H178	R:R:M109	19.7	No	No	0	4	3
16	R:R:M109	R:R:V179	7.61	No	No	0	3	4
17	R:R:K376	R:R:V110	4.55	Yes	No	0	2	3
18	R:R:I119	R:R:L111	15.7	No	No	0	5	4
19	R:R:F177	R:R:L111	10.96	No	No	0	4	4
20	R:R:N112	R:R:P113	6.52	Yes	No	0	6	2
21	R:R:N112	R:R:S114	2.98	Yes	No	0	6	5
22	R:R:N112	R:R:T377	2.92	Yes	No	0	6	1
23	R:R:A118	R:R:Q115	7.58	No	No	0	5	2
24	R:R:F180	R:R:Q116	3.51	Yes	No	0	4	4
25	R:R:F381	R:R:I119	12.56	No	No	0	4	5
26	R:R:F381	R:R:L122	3.65	No	No	0	4	5
27	R:R:F174	R:R:S123	3.96	Yes	No	0	5	7
28	R:R:G127	R:R:L126	3.42	No	No	0	6	6
29	R:R:L126	R:R:M384	5.65	No	No	0	6	5
30	R:R:F129	R:R:T128	3.89	No	No	0	4	5
31	R:R:E133	R:R:F129	5.83	Yes	No	0	8	4
32	R:R:E133	R:R:T130	2.82	Yes	Yes	0	8	7
33	R:R:S167	R:R:T130	4.8	No	Yes	0	7	7
34	R:R:L387	R:R:T130	2.95	No	Yes	2	7	7
35	R:R:S390	R:R:T130	3.2	Yes	Yes	2	9	7
36	R:R:L132	R:R:L136	2.77	No	No	0	3	7
37	R:R:E133	R:R:T391	4.23	Yes	No	0	8	7
38	R:R:D163	R:R:N134	6.73	Yes	No	2	9	9
39	R:R:N134	R:R:P394	11.4	No	Yes	2	9	9
40	R:R:L135	R:R:L164	2.77	No	No	0	3	7
41	R:R:P394	R:R:V137	5.3	Yes	No	0	9	9
42	R:R:I141	R:R:L138	4.28	No	No	0	7	7
43	R:R:L138	R:R:V161	4.47	No	No	0	7	6
44	R:R:R148	R:R:V140	2.62	Yes	No	0	8	8
45	R:R:R148	R:R:S146	9.22	Yes	No	0	8	5
46	R:R:C149	R:R:L147	3.17	No	No	0	7	9
47	R:R:R148	R:R:Y153	11.32	Yes	Yes	6	8	9
48	R:R:D403	R:R:R148	4.76	Yes	Yes	6	6	8
49	R:R:H406	R:R:R148	11.28	No	Yes	0	4	8
50	R:R:P151	R:R:R150	2.88	No	No	0	5	5
51	R:R:R150	R:R:Y153	8.23	No	Yes	0	5	9
52	R:R:P151	R:R:V228	3.53	No	No	0	5	6
53	R:R:D213	R:R:S152	7.36	Yes	No	0	9	8
54	R:R:D403	R:R:Y153	12.64	Yes	Yes	6	6	9
55	R:R:F155	R:R:H154	4.53	Yes	Yes	4	8	3
56	R:R:A233	R:R:H154	2.93	No	Yes	4	7	3
57	R:R:H154	R:R:V234	4.15	Yes	No	0	3	1
58	R:R:F237	R:R:H154	4.53	Yes	Yes	4	8	3
59	R:R:F155	R:R:L209	10.96	Yes	Yes	0	8	6
60	R:R:D213	R:R:F155	4.78	Yes	Yes	0	9	8
61	R:R:A233	R:R:F155	4.16	No	Yes	4	7	8
62	R:R:S158	R:R:S206	6.52	No	No	0	9	8
63	R:R:F237	R:R:S158	7.93	Yes	No	4	8	9
64	R:R:S158	R:R:W241	8.65	No	Yes	4	9	9
65	R:R:L159	R:R:S206	6.01	No	No	0	9	8
66	R:R:A162	R:R:W241	3.89	No	Yes	0	8	9
67	R:R:D163	R:R:S390	8.83	Yes	Yes	2	9	9
68	R:R:D163	R:R:N393	2.69	Yes	Yes	2	9	9
69	R:R:D163	R:R:P394	4.83	Yes	Yes	2	9	9
70	R:R:L164	R:R:S167	7.51	No	No	0	7	7
71	R:R:G166	R:R:L165	3.42	No	No	7	8	6
72	R:R:I169	R:R:L165	5.71	No	No	0	5	6
73	R:R:L165	R:R:S199	6.01	No	No	7	6	7
74	R:R:G166	R:R:S199	3.71	No	No	7	8	7
75	R:R:S167	R:R:V168	3.23	No	No	0	7	4
76	R:R:G195	R:R:I169	7.05	No	No	0	4	5
77	R:R:I169	R:R:V196	3.07	No	No	0	5	7
78	R:R:F170	R:R:F174	9.65	Yes	Yes	1	7	5
79	R:R:F170	R:R:F200	5.36	Yes	Yes	1	7	7
80	R:R:F170	R:R:S383	6.61	Yes	Yes	1	7	6
81	R:R:I175	R:R:Y172	7.25	No	No	0	5	7
82	R:R:K192	R:R:Y172	3.58	Yes	No	0	6	7
83	R:R:F174	R:R:M384	2.49	Yes	No	0	5	5
84	R:R:D176	R:R:F189	3.58	No	Yes	1	3	9
85	R:R:D176	R:R:K192	8.3	No	Yes	1	3	6
86	R:R:F177	R:R:V179	3.93	No	No	0	4	4
87	R:R:D184	R:R:H178	8.82	Yes	No	0	2	4
88	R:R:F180	R:R:V179	6.55	Yes	No	0	4	4
89	R:R:F180	R:R:H181	3.39	Yes	No	0	4	3
90	R:R:D184	R:R:F189	4.78	Yes	Yes	0	2	9
91	R:R:R186	R:R:S185	2.64	No	No	0	3	7
92	R:R:N187	R:R:R186	4.82	No	No	0	1	3
93	R:R:F189	R:R:K192	4.96	Yes	Yes	1	9	6
94	R:R:L190	R:R:L193	2.77	No	Yes	1	5	4
95	R:R:L190	R:R:P251	3.28	No	Yes	1	5	6
96	R:R:I271	R:R:L190	2.85	Yes	No	1	3	5
97	R:R:F191	R:R:L252	7.31	No	No	0	5	5
98	R:R:G194	R:R:L193	3.42	No	Yes	0	6	4
99	R:R:I271	R:R:L193	4.28	Yes	Yes	1	3	4
100	R:R:F200	R:R:V196	5.24	Yes	No	1	7	7
101	R:R:T197	R:R:T201	3.14	No	Yes	0	6	6
102	R:R:A248	R:R:T197	5.03	No	No	0	7	6
103	R:R:C386	R:R:F200	6.98	No	Yes	0	7	7
104	R:R:A244	R:R:T201	3.36	No	Yes	0	8	6
105	R:R:I247	R:R:T201	3.04	No	Yes	0	5	6
106	R:R:T201	R:R:W279	6.06	Yes	Yes	0	6	6
107	R:R:A202	R:R:W241	7.78	No	Yes	0	7	9
108	R:R:L286	R:R:V204	4.47	No	No	0	8	7
109	R:R:L287	R:R:V204	2.98	No	No	1	6	7
110	R:R:V204	R:R:W356	4.9	No	Yes	1	7	8
111	R:R:G205	R:R:M240	5.24	No	No	0	5	6
112	R:R:I290	R:R:L207	4.28	No	No	0	8	8
113	R:R:L207	R:R:Y397	7.03	No	Yes	0	8	9
114	R:R:F208	R:R:L286	9.74	No	No	0	7	8
115	R:R:F208	R:R:F289	6.43	No	No	0	7	6
116	R:R:F208	R:R:I290	8.79	No	No	0	7	8
117	R:R:I212	R:R:L209	2.85	No	Yes	0	7	6
118	R:R:A236	R:R:L209	3.15	No	Yes	0	5	6
119	R:R:L209	R:R:M240	5.65	Yes	No	0	6	6
120	R:R:R214	R:R:T210	3.88	No	No	0	9	9
121	R:R:A211	R:R:I290	4.87	No	No	0	8	8
122	R:R:A211	R:R:Y294	6.67	No	Yes	0	8	9
123	R:R:D213	R:R:I216	2.8	Yes	No	0	9	5
124	R:R:D213	R:R:Y224	4.6	Yes	No	0	9	7
125	R:R:R214	R:R:Y294	8.23	No	Yes	0	9	9
126	R:R:R214	R:R:Y397	5.14	No	Yes	0	9	9
127	R:R:H219	R:R:Y215	10.89	No	Yes	5	6	8
128	R:R:Y215	R:R:Y292	4.96	Yes	No	5	8	4
129	R:R:A293	R:R:Y215	2.67	No	Yes	0	7	8
130	R:R:Y215	R:R:Y296	11.91	Yes	Yes	5	8	4
131	R:R:I216	R:R:I227	2.94	No	No	0	5	4
132	R:R:I216	R:R:V228	3.07	No	No	0	5	6
133	R:R:S217	R:R:Y224	10.17	No	No	0	8	7
134	R:R:I218	R:R:I297	7.36	No	No	0	9	9
135	R:R:H219	R:R:Y296	8.71	No	Yes	5	6	4
136	R:R:H219	R:R:K300	5.24	No	No	5	6	5
137	R:R:L222	R:R:R220	6.07	No	No	0	7	5
138	R:R:A223	R:R:R220	8.3	No	No	0	5	5
139	R:R:A223	R:R:R226	5.53	No	No	0	5	4
140	R:R:V228	R:R:Y224	2.52	No	No	0	6	7
141	R:R:R230	R:R:T229	3.88	No	No	9	1	8
142	R:R:P231	R:R:T229	10.49	No	No	9	4	8
143	R:R:P231	R:R:R230	5.76	No	No	9	4	1
144	R:R:K232	R:R:V235	7.59	No	No	0	5	3
145	R:R:F237	R:R:W241	11.02	Yes	Yes	4	8	9
146	R:R:L239	R:R:T242	2.95	No	No	0	3	4
147	R:R:I243	R:R:L239	5.71	No	No	0	5	3
148	R:R:F278	R:R:I247	3.77	No	No	8	6	5
149	R:R:I247	R:R:V282	6.14	No	No	8	5	6
150	R:R:L252	R:R:V249	13.41	No	No	0	5	5
151	R:R:L250	R:R:P251	4.93	No	Yes	0	5	6
152	R:R:L250	R:R:Y275	16.41	No	Yes	0	5	7
153	R:R:I271	R:R:P251	3.39	Yes	Yes	1	3	6
154	R:R:F268	R:R:I267	3.77	Yes	No	3	5	4
155	R:R:D366	R:R:I267	7	No	No	3	4	4
156	R:R:I267	R:R:M371	8.75	No	Yes	3	4	1
157	R:R:D366	R:R:F268	10.75	No	Yes	3	4	5
158	R:R:F268	R:R:M371	8.71	Yes	Yes	3	5	1
159	R:R:F268	R:R:I375	2.51	Yes	Yes	3	5	3
160	R:R:F268	R:R:K376	8.69	Yes	Yes	3	5	2
161	R:R:F268	R:R:F379	11.79	Yes	Yes	0	5	4
162	R:R:I271	R:R:P269	5.08	Yes	No	0	3	3
163	R:R:D272	R:R:T274	8.67	No	No	0	5	5
164	R:R:D272	R:R:Y275	3.45	No	Yes	0	5	7
165	R:R:E273	R:R:T274	5.64	No	No	0	3	5
166	R:R:E273	R:R:V367	4.28	No	No	0	3	4
167	R:R:F278	R:R:Y275	3.09	No	Yes	0	6	7
168	R:R:L276	R:R:M363	8.48	No	Yes	1	5	6
169	R:R:M277	R:R:V367	10.65	No	No	0	4	4
170	R:R:F278	R:R:V282	2.62	No	No	8	6	6
171	R:R:T283	R:R:W279	8.49	No	Yes	1	8	6
172	R:R:W279	R:R:W356	4.69	Yes	Yes	1	6	8
173	R:R:M363	R:R:W279	4.65	Yes	Yes	1	6	6
174	R:R:I280	R:R:L360	4.28	No	No	0	5	7
175	R:R:I280	R:R:M363	2.92	No	Yes	0	5	6
176	R:R:L286	R:R:V282	2.98	No	No	0	8	6
177	R:R:T283	R:R:W356	8.49	No	Yes	1	8	8
178	R:R:L360	R:R:T283	2.95	No	No	1	7	8
179	R:R:L287	R:R:L352	9.69	No	No	0	6	9
180	R:R:L287	R:R:W356	7.97	No	Yes	1	6	8
181	R:R:M295	R:R:V291	4.56	No	No	10	3	5
182	R:R:L349	R:R:V291	4.47	No	No	10	8	5
183	R:R:Y292	R:R:Y296	2.98	No	Yes	5	4	4
184	R:R:L345	R:R:Y294	8.21	No	Yes	0	8	9
185	R:R:I348	R:R:Y294	9.67	No	Yes	0	8	9
186	R:R:L349	R:R:Y294	5.86	No	Yes	0	8	9
187	R:R:L349	R:R:M295	2.83	No	No	10	8	3
188	R:R:W299	R:R:Y296	7.72	No	Yes	0	3	4
189	R:R:K300	R:R:Y296	11.94	No	Yes	5	5	4
190	R:R:I297	R:R:L341	2.85	No	No	0	9	8
191	R:R:L298	R:R:L341	2.77	No	No	11	6	8
192	R:R:L298	R:R:L345	8.3	No	No	11	6	8
193	R:R:K300	R:R:S303	3.06	No	No	0	5	5
194	R:R:A301	R:R:D338	3.09	No	Yes	0	8	7
195	R:R:D338	R:R:H302	8.82	Yes	No	0	7	5
196	R:R:H304	R:R:M308	6.57	No	No	0	7	7
197	R:R:A305	R:R:D338	4.63	No	Yes	0	5	7
198	R:R:Q310	R:R:V306	2.87	No	No	0	4	5
199	R:R:Q310	R:R:R307	4.67	No	No	0	4	4
200	R:R:R307	R:R:R311	4.26	No	No	0	4	5
201	R:R:A335	R:R:D338	4.63	No	Yes	0	4	7
202	R:R:R336	R:R:R340	6.4	No	No	0	4	7
203	R:R:I339	R:R:K343	2.91	No	No	0	5	7
204	R:R:L341	R:R:L345	6.92	No	No	11	8	8
205	R:R:I396	R:R:L347	4.28	No	No	0	9	7
206	R:R:I348	R:R:Y397	12.09	No	Yes	0	8	9
207	R:R:V351	R:R:V392	3.21	No	Yes	12	6	6
208	R:R:I396	R:R:V351	4.61	No	No	12	9	6
209	R:R:C355	R:R:W356	9.14	No	Yes	0	8	8
210	R:R:C355	R:R:N389	11.02	No	No	0	8	9
211	R:R:L360	R:R:W356	9.11	No	Yes	1	7	8
212	R:R:G357	R:R:P358	4.06	No	No	0	5	9
213	R:R:F379	R:R:L359	3.65	Yes	Yes	0	4	7
214	R:R:C382	R:R:L359	6.35	No	Yes	0	5	7
215	R:R:L359	R:R:S383	3	Yes	Yes	0	7	6
216	R:R:L359	R:R:L385	2.77	Yes	No	0	7	7
217	R:R:F379	R:R:I362	7.54	Yes	No	0	4	4
218	R:R:F379	R:R:M363	2.49	Yes	Yes	0	4	6
219	R:R:G369	R:R:Y365	2.9	No	No	0	3	4
220	R:R:D366	R:R:M371	6.93	No	Yes	3	4	1
221	R:R:F368	R:R:V367	2.62	No	No	0	5	4
222	R:R:I375	R:R:M371	5.83	Yes	Yes	3	3	1
223	R:R:K376	R:R:M371	5.76	Yes	Yes	3	2	1
224	R:R:L374	R:R:N372	5.49	No	No	0	4	1
225	R:R:K373	R:R:L374	2.82	No	No	0	3	4
226	R:R:I375	R:R:L374	2.85	Yes	No	0	3	4
227	R:R:I375	R:R:K376	4.36	Yes	Yes	3	3	2
228	R:R:C386	R:R:S383	3.44	No	Yes	0	7	6
229	R:R:L385	R:R:L388	5.54	No	No	0	7	5
230	R:R:L387	R:R:S390	7.51	No	Yes	2	7	9
231	R:R:N389	R:R:S390	2.98	No	Yes	0	9	9
232	R:R:N389	R:R:N393	6.81	No	Yes	0	9	9
233	R:R:I396	R:R:V392	4.61	No	Yes	12	9	6
234	R:R:N393	R:R:P394	3.26	Yes	Yes	2	9	9
235	R:R:N393	R:R:Y397	8.14	Yes	Yes	0	9	9
236	R:R:A398	R:R:L404	3.15	No	No	0	7	8
237	R:R:D403	R:R:S401	2.94	Yes	No	0	6	8
238	R:R:K402	R:R:R405	22.28	No	No	0	5	8
239	R:R:D403	R:R:L404	6.79	Yes	No	0	6	8
240	R:R:L399	R:R:R400	2.43	No	No	0	5	7
241	R:R:I156	R:R:Y153	2.42	No	Yes	0	8	9
242	R:R:I156	R:R:Y397	2.42	No	Yes	0	8	9
243	L:L:?1	R:R:S173	2.16	Yes	No	0	0	4
244	R:R:A160	R:R:G157	1.95	No	No	0	9	6
245	R:R:A198	R:R:G195	1.95	No	No	0	5	4
246	R:R:C382	R:R:P358	1.88	No	No	0	5	9
247	R:R:G127	R:R:V171	1.84	No	No	0	6	7
248	R:R:A211	R:R:A293	1.79	No	No	0	8	7
249	R:R:G157	R:R:I156	1.76	No	No	0	6	8
250	R:R:C149	R:R:S144	1.72	No	No	0	7	6
251	R:R:A407	R:R:S146	1.71	No	No	0	7	5
252	R:R:L222	R:R:P221	1.64	No	No	0	7	8
253	R:R:L252	R:R:P251	1.64	No	Yes	0	5	6
254	R:R:A198	R:R:I245	1.62	No	No	0	5	4
255	R:R:A301	R:R:I218	1.62	No	No	0	8	9
256	R:R:A223	R:R:I227	1.62	No	No	0	5	4
257	R:R:A335	R:R:I339	1.62	No	No	0	4	5
258	R:R:A301	R:R:M337	1.61	No	No	0	8	6
259	R:R:A305	R:R:M337	1.61	No	No	0	5	6
260	R:R:S401	R:R:T344	1.6	No	No	0	8	8
261	R:R:V346	R:R:V350	1.6	No	No	0	6	6
262	R:R:C139	R:R:L142	1.59	No	No	0	4	4
263	R:R:T391	R:R:V392	1.59	No	Yes	0	7	6
264	R:R:A160	R:R:L138	1.58	No	No	0	9	7
265	R:R:A342	R:R:L298	1.58	No	No	0	7	6
266	R:R:I280	R:R:S284	1.55	No	No	0	5	5
267	R:R:I395	R:R:V392	1.54	No	Yes	0	6	6
268	R:R:K232	R:R:T229	1.5	No	No	0	5	8
269	R:R:L117	R:R:V121	1.49	No	No	0	5	4
270	R:R:N393	R:R:S203	1.49	Yes	No	0	9	9
271	R:R:C139	R:R:H143	1.47	No	No	0	4	5
272	R:R:D184	R:R:S185	1.47	Yes	No	0	2	7
273	R:R:I175	R:R:L124	1.43	No	No	0	5	3
274	R:R:I353	R:R:L352	1.43	No	No	0	6	9
275	R:R:I354	R:R:L388	1.43	No	No	0	5	5
276	R:R:I395	R:R:L399	1.43	No	No	0	6	5
277	R:R:I119	R:R:N112	1.42	No	Yes	0	5	6
278	R:R:L239	R:R:M240	1.41	No	No	0	3	6
279	R:R:C238	R:R:F237	1.4	No	Yes	0	4	8
280	R:R:K370	R:R:N372	1.4	No	No	0	1	1
281	R:R:A120	R:R:F180	1.39	No	Yes	0	5	4
282	R:R:H143	R:R:S146	1.39	No	No	0	5	5
283	R:R:A407	R:R:F408	1.39	No	No	0	7	7
284	R:R:D184	R:R:K183	1.38	Yes	No	0	2	6
285	R:R:L117	R:R:Q115	1.33	No	No	0	5	2
286	R:R:E133	R:R:L132	1.33	Yes	No	0	8	3
287	R:R:H304	R:R:M337	1.31	No	No	0	7	6
288	R:R:F381	R:R:V378	1.31	No	No	0	4	4
289	R:R:I339	R:R:R336	1.25	No	No	0	5	4
290	R:R:K192	R:R:R182	1.24	Yes	No	0	6	4
291	R:R:I375	R:R:Y365	1.21	Yes	No	0	3	4
292	R:R:L399	R:R:R405	1.21	No	No	0	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.13214	14	1	0
2	R:R:N112	3.46	4	0	6
3	R:R:T130	3.4425	4	2	7
4	R:R:E133	3.5525	4	0	8
5	R:R:R148	7.84	5	6	8
6	R:R:Y153	8.6525	4	6	9
7	R:R:H154	4.035	4	4	3
8	R:R:F155	6.1075	4	4	8
9	R:R:D163	5.77	4	2	9
10	R:R:F170	7.3775	4	1	7
11	R:R:F174	4.6825	4	1	5
12	R:R:F180	3.71	4	0	4
13	R:R:D184	4.1125	4	0	2
14	R:R:F189	4.2075	4	1	9
15	R:R:K192	4.52	4	1	6
16	R:R:L193	6.1025	4	1	4
17	R:R:F200	7.6825	4	1	7
18	R:R:T201	3.9	4	0	6
19	R:R:L209	5.6525	4	0	6
20	R:R:D213	4.885	4	0	9
21	R:R:Y215	7.6075	4	5	8
22	R:R:F237	6.22	4	4	8
23	R:R:W241	7.835	4	4	9
24	R:R:P251	3.31	4	1	6
25	R:R:F268	7.70333	6	3	5
26	R:R:I271	3.9	4	1	3
27	R:R:Y275	7.215	4	0	7
28	R:R:W279	6.09	5	1	6
29	R:R:Y294	7.728	5	0	9
30	R:R:Y296	8.652	5	5	4
31	R:R:D338	5.2925	4	0	7
32	R:R:W356	7.38333	6	1	8
33	R:R:L359	3.9425	4	0	7
34	R:R:M363	4.318	5	1	6
35	R:R:M371	7.196	5	3	1
36	R:R:I375	3.352	5	3	3
37	R:R:K376	5.84	4	3	2
38	R:R:F379	6.3675	4	0	4
39	R:R:S383	4.6125	4	1	6
40	R:R:S390	5.63	4	2	9
41	R:R:V392	2.7375	4	12	6
42	R:R:N393	4.478	5	2	9
43	R:R:P394	6.1975	4	2	9
44	R:R:Y397	6.964	5	0	9
45	R:R:D403	6.7825	4	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F379	R:R:M363	26.4925	2.49	Yes	Yes	0	4	6
2	R:R:F268	R:R:F379	18.3436	11.79	Yes	Yes	0	5	4
3	L:L:?1	R:R:F189	41.0105	3.51	Yes	Yes	1	0	9
4	R:R:D184	R:R:F189	31.9995	4.78	Yes	Yes	0	2	9
5	R:R:D184	R:R:H178	24.9657	8.82	Yes	No	0	2	4
6	R:R:H178	R:R:M109	23.5332	19.7	No	No	0	4	3
7	R:R:M109	R:R:V179	22.0921	7.61	No	No	0	3	4
8	R:R:F177	R:R:V179	15.0283	3.93	No	No	0	4	4
9	R:R:F177	R:R:L111	13.5272	10.96	No	No	0	4	4
10	R:R:I119	R:R:L111	12.0261	15.7	No	No	0	5	4
11	L:L:?1	R:R:W279	70.7883	6.56	Yes	Yes	1	0	6
12	R:R:W279	R:R:W356	93.6567	4.69	Yes	Yes	1	6	8
13	R:R:C355	R:R:W356	82.0424	9.14	No	Yes	0	8	8
14	R:R:C355	R:R:N389	82.2354	11.02	No	No	0	8	9
15	R:R:N389	R:R:S390	29.8079	2.98	No	Yes	0	9	9
16	R:R:S390	R:R:T130	40.6245	3.2	Yes	Yes	2	9	7
17	R:R:E133	R:R:T130	30.8029	2.82	Yes	Yes	0	8	7
18	R:R:E133	R:R:T391	20.6811	4.23	Yes	No	0	8	7
19	R:R:D163	R:R:S390	17.1513	8.83	Yes	Yes	2	9	9
20	R:R:N389	R:R:N393	83.8737	6.81	No	Yes	0	9	9
21	R:R:D163	R:R:N393	18.2235	2.69	Yes	Yes	2	9	9
22	R:R:N393	R:R:Y397	100	8.14	Yes	Yes	0	9	9
23	R:R:I156	R:R:Y397	93.4723	2.42	No	Yes	0	8	9
24	R:R:I156	R:R:Y153	87.9396	2.42	No	Yes	0	8	9
25	R:R:R148	R:R:Y153	13.1583	11.32	Yes	Yes	6	8	9
26	R:R:R150	R:R:Y153	73.2802	8.23	No	Yes	0	5	9
27	R:R:P151	R:R:R150	72.1993	2.88	No	No	0	5	5
28	R:R:P151	R:R:V228	71.0842	3.53	No	No	0	5	6
29	R:R:I216	R:R:V228	38.45	3.07	No	No	0	5	6
30	R:R:D213	R:R:I216	29.958	2.8	Yes	No	0	9	5
31	R:R:V228	R:R:Y224	31.7979	2.52	No	No	0	6	7
32	R:R:D213	R:R:Y224	29.4733	4.6	Yes	No	0	9	7
33	R:R:D213	R:R:F155	54.1045	4.78	Yes	Yes	0	9	8
34	R:R:F155	R:R:H154	27.4447	4.53	Yes	Yes	4	8	3
35	R:R:F237	R:R:H154	22.0578	4.53	Yes	Yes	4	8	3
36	R:R:F155	R:R:L209	22.0578	10.96	Yes	Yes	0	8	6
37	L:L:?1	R:R:V196	12.2105	17.15	Yes	No	1	0	7
38	R:R:I169	R:R:V196	10.8037	3.07	No	No	0	5	7
39	L:L:?1	R:R:L193	12.678	13.94	Yes	Yes	1	0	4
40	L:L:?1	R:R:Y275	22.358	5.91	Yes	Yes	0	0	7
41	R:R:L252	R:R:P251	12.515	1.64	No	Yes	0	5	6
42	L:L:?1	R:R:S383	12.7209	5.4	Yes	Yes	1	0	6
43	R:R:F278	R:R:Y275	18.6052	3.09	No	Yes	0	6	7
44	R:R:F278	R:R:V282	18.3694	2.62	No	No	8	6	6
45	R:R:L286	R:R:V282	19.8533	2.98	No	No	0	8	6
46	R:R:V204	R:R:W356	17.3658	4.9	No	Yes	1	7	8
47	R:R:L286	R:R:V204	17.473	4.47	No	No	0	8	7
48	R:R:L209	R:R:M240	13.8489	5.65	Yes	No	0	6	6
49	R:R:F208	R:R:L286	36.1211	9.74	No	No	0	7	8
50	R:R:F208	R:R:I290	35.8037	8.79	No	No	0	7	8
51	R:R:I290	R:R:L207	14.7753	4.28	No	No	0	8	8
52	R:R:L207	R:R:Y397	15.0026	7.03	No	Yes	0	8	9
53	R:R:A211	R:R:I290	33.5478	4.87	No	No	0	8	8
54	R:R:A211	R:R:Y294	32.111	6.67	No	Yes	0	8	9
55	R:R:A211	R:R:A293	25.9092	1.79	No	No	0	8	7
56	R:R:A293	R:R:Y215	23.3316	2.67	No	Yes	0	7	8
57	R:R:Y215	R:R:Y296	10.4949	11.91	Yes	Yes	5	8	4
58	R:R:R214	R:R:Y397	30.4297	5.14	No	Yes	0	9	9
59	R:R:R214	R:R:Y294	28.6842	8.23	No	Yes	0	9	9
60	R:R:L345	R:R:Y294	53.1867	8.21	No	Yes	0	8	9
61	R:R:L341	R:R:L345	44.7418	6.92	No	No	11	8	8
62	R:R:I297	R:R:L341	42.4773	2.85	No	No	0	9	8
63	R:R:I218	R:R:I297	39.6895	7.36	No	No	0	9	9
64	R:R:I348	R:R:Y397	29.3661	12.09	No	Yes	0	8	9
65	R:R:I348	R:R:Y294	28.4225	9.67	No	Yes	0	8	9
66	R:R:A301	R:R:I218	37.1633	1.62	No	No	0	8	9
67	R:R:A301	R:R:D338	22.9842	3.09	No	Yes	0	8	7
68	R:R:A301	R:R:M337	11.5286	1.61	No	No	0	8	6
69	R:R:A335	R:R:D338	14.5136	4.63	No	Yes	0	4	7
70	R:R:A335	R:R:I339	11.6272	1.62	No	No	0	4	5
71	R:R:T391	R:R:V392	18.631	1.59	No	Yes	0	7	6
72	R:R:L359	R:R:S383	10.5421	3	Yes	Yes	0	7	6
73	R:R:I395	R:R:V392	10.5464	1.54	No	Yes	0	6	6
74	R:R:M363	R:R:W279	22.3623	4.65	Yes	Yes	1	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F170	7.89	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F174	2.63	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F189	3.51	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:L193	13.94	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:V196	17.15	1	Yes	No	0	7	0	1
L:L:?1	R:R:T197	7.43	1	Yes	No	0	6	0	1
L:L:?1	R:R:F200	13.15	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:P269	7.09	1	Yes	No	0	3	0	1
L:L:?1	R:R:Y275	5.91	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:L276	3.98	1	Yes	No	0	5	0	1
L:L:?1	R:R:W279	6.56	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:M363	3.05	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:S383	5.4	1	Yes	Yes	0	6	0	1
R:R:F174	R:R:S123	3.96	1	Yes	No	5	7	1	2
R:R:I169	R:R:V196	3.07	0	No	No	5	7	2	1
R:R:F170	R:R:F174	9.65	1	Yes	Yes	7	5	1	1
R:R:F170	R:R:F200	5.36	1	Yes	Yes	7	7	1	1
R:R:F170	R:R:S383	6.61	1	Yes	Yes	7	6	1	1
R:R:F174	R:R:M384	2.49	1	Yes	No	5	5	1	2
R:R:D176	R:R:F189	3.58	1	No	Yes	3	9	2	1
R:R:D176	R:R:K192	8.3	1	No	Yes	3	6	2	2
R:R:D184	R:R:F189	4.78	0	Yes	Yes	2	9	2	1
R:R:F189	R:R:K192	4.96	1	Yes	Yes	9	6	1	2
R:R:L190	R:R:L193	2.77	1	No	Yes	5	4	2	1
R:R:I271	R:R:L190	2.85	1	Yes	No	3	5	2	2
R:R:G194	R:R:L193	3.42	0	No	Yes	6	4	2	1
R:R:I271	R:R:L193	4.28	1	Yes	Yes	3	4	2	1
R:R:F200	R:R:V196	5.24	1	Yes	No	7	7	1	1
R:R:T197	R:R:T201	3.14	0	No	Yes	6	6	1	2
R:R:A248	R:R:T197	5.03	0	No	No	7	6	2	1
R:R:C386	R:R:F200	6.98	0	No	Yes	7	7	2	1
R:R:T201	R:R:W279	6.06	0	Yes	Yes	6	6	2	1
R:R:L250	R:R:Y275	16.41	0	No	Yes	5	7	2	1
R:R:I271	R:R:P269	5.08	1	Yes	No	3	3	2	1
R:R:D272	R:R:Y275	3.45	0	No	Yes	5	7	2	1
R:R:F278	R:R:Y275	3.09	8	No	Yes	6	7	2	1
R:R:L276	R:R:M363	8.48	1	No	Yes	5	6	1	1
R:R:T283	R:R:W279	8.49	1	No	Yes	8	6	2	1
R:R:W279	R:R:W356	4.69	1	Yes	Yes	6	8	1	2
R:R:M363	R:R:W279	4.65	1	Yes	Yes	6	6	1	1
R:R:I280	R:R:M363	2.92	0	No	Yes	5	6	2	1
R:R:T283	R:R:W356	8.49	1	No	Yes	8	8	2	2
R:R:F379	R:R:L359	3.65	0	Yes	Yes	4	7	2	2
R:R:L359	R:R:S383	3	0	Yes	Yes	7	6	2	1
R:R:F379	R:R:M363	2.49	0	Yes	Yes	4	6	2	1
R:R:C386	R:R:S383	3.44	0	No	Yes	7	6	2	1
L:L:?1	R:R:S173	2.16	1	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9B65_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.49
Number of Linked Nodes	251
Number of Links	292
Number of Hubs	45
Number of Links mediated by Hubs	158
Number of Communities	12
Number of Nodes involved in Communities	66
Number of Links involved in Communities	87

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	53670
Length Of Smallest Path	3
Average Path Length	14.3032
Length of Longest Path	30
Minimum Path Strength	1.32
Average Path Strength	5.69595
Maximum Path Strength	15.545
Minimum Path Correlation	0.7
Average Path Correlation	0.916487
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	42.6622
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.8693
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	KCA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	KCA
Name	methyl N-{1-[(4-fluorophenyl)methyl]-1H-indazole-3-carbonyl}-3-methyl-L-valinate
Synonyms
Identifier
Formula	C22 H24 F N3 O3
Molecular Weight	397.443
SMILES
PubChem	119025665
Formal Charge	0
Total Atoms	53
Total Chiral Atoms	1
Total Bonds	55
Total Aromatic Bonds	16


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21554
Sequence	>9B65_nogp_Chain_R F M V L N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R S L R C R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V F H R K D S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R P L A Y K R I V T R P K A V V A F C L M W T I A I V I A V L P L L D I F P H I D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G K M N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D L R H A F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7FEE	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	-	2.7	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	7WV9	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	Gi2/β1/γ2	3.36	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	7WV9 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011		3.36	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	8IKH	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2L	Gi1/β1/γ1	3.3	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKH (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2L		3.3	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2B	Gi1/β1/γ1	3.4	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2B		3.4	2024-06-05	doi.org/10.1073/pnas.2321532121
	6KQI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	Org27569	-	3.25	2019-10-23	doi.org/10.1038/s41589-019-0387-2
	8K8J	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-	chim(Gs-CtGq)/β1/γ2	2.88	2024-02-14	doi.org/10.1002/advs.202306311
	8K8J (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-		2.88	2024-02-14	doi.org/10.1002/advs.202306311
	5TGZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM6538	-	-	2.8	2016-11-02	doi.org/10.1016/j.cell.2016.10.004
	6N4B	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-	Gi1/β1/γ2	3	2019-01-30	doi.org/10.1016/j.cell.2018.11.040
	6N4B (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-		3	2019-01-30	doi.org/10.1016/j.cell.2018.11.040
	6KPG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	Gi1/β1/γ2	3	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-		3	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	7V3Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	-	-	3.29	2021-11-24	doi.org/10.1021/jacs.1c06847
	5U09	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Taranabant	-	-	2.6	2016-12-07	doi.org/10.1038/nature20613
	5XR8	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	-	2.95	2017-07-12	doi.org/10.1038/nature23272
	5XRA	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM11542	-	-	2.8	2017-07-12	doi.org/10.1038/nature23272
	8GHV	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-	Gi1/β1/γ2	2.8	2023-05-24	doi.org/10.1038/s41467-023-37864-4
	8GHV (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-		2.8	2023-05-24	doi.org/10.1038/s41467-023-37864-4
	9B9Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKO	-	-	3.3	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9BA0	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKN	-	-	3.13	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9B9Y	A	Lipid	Cannabinoid	CB₁	Homo sapiens	7DY	-	-	3.5	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9B54	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-	Gi1/β1/γ2	2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B54 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-		2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B65	A	Lipid	Cannabinoid	CB₁	Homo sapiens	KCA	-	Gi1/β1/γ2	3.03	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B65 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	KCA	-		3.03	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	8WRZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 102336704	-	Arrestin2	3.6	2024-02-28	doi.org/10.1093/procel/pwad055
	9ERX	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-	Gi1/β1/γ2	2.9	2024-06-26	doi.org/10.21203/rs.3.rs-4277209/v1
	9ERX (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-		2.9	2024-06-26	doi.org/10.21203/rs.3.rs-4277209/v1
	8WU1	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 119025665	-	Arrestin2	3.2	2024-03-20	doi.org/10.1016/j.cell.2023.11.017
	9DGI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Z8526711350	-	-	3.35	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	9EGO	A	Lipid	Cannabinoid	CB₁	Homo sapiens	YVF	-	Gi1/β1/γ2	3.2	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	9EGO (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	YVF	-		3.2	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	8GAG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 170838490	-	Gi1/β1/γ2	3.3	2024-02-28	To be published
	8GAG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 170838490	-		3.3	2024-02-28	To be published

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