psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F108	R:R:M109	6.22	No	No	0	5	3
2	R:R:H181	R:R:M109	10.51	No	No	0	3	3
3	R:R:K376	R:R:V110	4.55	Yes	No	0	2	3
4	R:R:L111	R:R:Q116	17.3	No	No	0	4	4
5	R:R:N112	R:R:P113	8.15	No	No	0	6	2
6	R:R:N112	R:R:S114	4.47	No	No	0	6	5
7	R:R:N112	R:R:Q115	15.85	No	Yes	0	6	2
8	R:R:Q115	R:R:T377	4.25	Yes	No	5	2	1
9	R:R:F381	R:R:Q115	7.03	No	Yes	5	4	2
10	R:R:Q116	R:R:V179	11.46	No	No	0	4	4
11	R:R:F174	R:R:I119	3.77	Yes	No	0	5	5
12	R:R:L122	R:R:L126	2.77	No	No	3	5	6
13	R:R:L122	R:R:M384	4.24	No	Yes	3	5	5
14	R:R:M384	R:R:S123	6.13	Yes	No	0	5	7
15	R:R:L126	R:R:M384	2.83	No	Yes	3	6	5
16	R:R:L126	R:R:L387	8.3	No	Yes	3	6	7
17	R:R:G127	R:R:L387	5.13	No	Yes	0	6	7
18	R:R:N134	R:R:T130	4.39	No	Yes	0	9	7
19	R:R:S167	R:R:T130	6.4	No	Yes	3	7	7
20	R:R:L387	R:R:T130	5.9	Yes	Yes	3	7	7
21	R:R:S390	R:R:T130	7.99	No	Yes	0	9	7
22	R:R:T130	R:R:T391	4.71	Yes	No	0	7	7
23	R:R:L164	R:R:V131	4.47	No	No	0	7	6
24	R:R:S167	R:R:V131	3.23	No	No	0	7	6
25	R:R:E133	R:R:L136	3.98	No	No	0	8	7
26	R:R:E133	R:R:P394	4.72	No	No	0	8	9
27	R:R:D163	R:R:N134	8.08	Yes	No	0	9	9
28	R:R:L135	R:R:L164	4.15	No	No	0	3	7
29	R:R:A160	R:R:V137	3.39	No	No	0	9	9
30	R:R:A160	R:R:L138	6.3	No	No	0	9	7
31	R:R:L138	R:R:V161	2.98	No	No	0	7	6
32	R:R:C139	R:R:F408	2.79	No	No	0	4	7
33	R:R:F408	R:R:V140	3.93	No	No	0	7	8
34	R:R:A407	R:R:R148	4.15	No	No	0	7	8
35	R:R:M411	R:R:R148	6.2	No	No	0	5	8
36	R:R:C149	R:R:R230	6.96	No	Yes	0	7	1
37	R:R:P151	R:R:R150	2.88	No	No	0	5	5
38	R:R:R150	R:R:Y153	6.17	No	Yes	0	5	9
39	R:R:P151	R:R:V228	3.53	No	No	0	5	6
40	R:R:P151	R:R:R230	5.76	No	Yes	0	5	1
41	R:R:D213	R:R:S152	8.83	No	No	0	9	8
42	R:R:I156	R:R:Y153	3.63	No	Yes	0	8	9
43	R:R:S401	R:R:Y153	3.82	No	Yes	0	8	9
44	R:R:L404	R:R:Y153	10.55	No	Yes	0	8	9
45	R:R:H154	R:R:R230	9.03	No	Yes	0	3	1
46	R:R:A233	R:R:H154	5.85	No	No	0	7	3
47	R:R:F155	R:R:L209	21.92	No	No	0	8	6
48	R:R:S158	R:R:S206	6.52	No	No	0	9	8
49	R:R:F237	R:R:S158	6.61	No	No	6	8	9
50	R:R:S158	R:R:W241	6.18	No	Yes	6	9	9
51	R:R:D163	R:R:L159	4.07	Yes	Yes	2	9	9
52	R:R:L159	R:R:S206	7.51	Yes	No	0	9	8
53	R:R:L159	R:R:L207	5.54	Yes	No	2	9	8
54	R:R:L159	R:R:N393	5.49	Yes	Yes	2	9	9
55	R:R:V161	R:R:W241	3.68	No	Yes	0	6	9
56	R:R:A162	R:R:W241	2.59	No	Yes	0	8	9
57	R:R:D163	R:R:S203	5.89	Yes	No	0	9	9
58	R:R:D163	R:R:S390	8.83	Yes	No	0	9	9
59	R:R:D163	R:R:N393	2.69	Yes	Yes	2	9	9
60	R:R:L165	R:R:S199	6.01	No	No	0	6	7
61	R:R:G166	R:R:S199	3.71	No	No	0	8	7
62	R:R:F200	R:R:G166	3.01	Yes	No	0	7	8
63	R:R:L387	R:R:S167	3	Yes	No	3	7	7
64	R:R:I169	R:R:V196	3.07	No	No	0	5	7
65	R:R:F170	R:R:F174	3.22	Yes	Yes	1	7	5
66	R:R:F170	R:R:V196	5.24	Yes	No	1	7	7
67	R:R:F170	R:R:F200	3.22	Yes	Yes	1	7	7
68	R:R:F170	R:R:S383	2.64	Yes	No	1	7	6
69	L:L:?1	R:R:F170	10.81	Yes	Yes	1	0	7
70	R:R:D176	R:R:Y172	5.75	No	No	0	3	7
71	R:R:K192	R:R:S173	6.12	No	No	1	6	4
72	L:L:?1	R:R:S173	10	Yes	No	1	0	4
73	R:R:F174	R:R:H178	7.92	Yes	No	0	5	4
74	L:L:?1	R:R:F174	3.6	Yes	Yes	1	0	5
75	R:R:D176	R:R:F180	8.36	No	No	0	3	4
76	R:R:D176	R:R:R182	4.76	No	No	0	3	4
77	R:R:F177	R:R:H178	7.92	Yes	No	0	4	4
78	R:R:F177	R:R:F189	5.36	Yes	Yes	1	4	9
79	R:R:F177	R:R:P269	5.78	Yes	No	1	4	3
80	L:L:?1	R:R:F177	3.6	Yes	Yes	1	0	4
81	R:R:F180	R:R:V179	2.62	No	No	0	4	4
82	R:R:D184	R:R:R182	3.57	No	No	0	2	4
83	R:R:D184	R:R:V188	10.22	No	No	0	2	5
84	R:R:D184	R:R:F189	3.58	No	Yes	0	2	9
85	R:R:N187	R:R:S185	8.94	No	No	7	1	7
86	R:R:S185	R:R:V188	3.23	No	No	7	7	5
87	R:R:L190	R:R:R186	9.72	No	No	0	5	3
88	R:R:N187	R:R:V188	4.43	No	No	7	1	5
89	R:R:F189	R:R:L193	4.87	Yes	No	1	9	4
90	R:R:F189	R:R:P269	10.11	Yes	No	1	9	3
91	R:R:F189	R:R:H270	10.18	Yes	No	1	9	3
92	L:L:?1	R:R:F189	2.7	Yes	Yes	1	0	9
93	R:R:L190	R:R:P251	6.57	No	No	0	5	6
94	R:R:H270	R:R:L190	2.57	No	No	0	3	5
95	L:L:?1	R:R:K192	4.17	Yes	No	1	0	6
96	R:R:I271	R:R:L193	2.85	Yes	No	1	3	4
97	L:L:?1	R:R:L193	9.22	Yes	No	1	0	4
98	L:L:?1	R:R:V196	5.51	Yes	No	1	0	7
99	R:R:I247	R:R:T197	3.04	No	No	0	5	6
100	L:L:?1	R:R:T197	12	Yes	No	0	0	6
101	R:R:C386	R:R:F200	9.78	No	Yes	0	7	7
102	L:L:?1	R:R:F200	2.7	Yes	Yes	1	0	7
103	R:R:A202	R:R:W241	3.89	No	Yes	0	7	9
104	R:R:L286	R:R:V204	5.96	Yes	No	0	8	7
105	R:R:V204	R:R:W356	4.9	No	Yes	0	7	8
106	R:R:L207	R:R:N393	5.49	No	Yes	2	8	9
107	R:R:L207	R:R:Y397	7.03	No	No	0	8	9
108	R:R:F208	R:R:L286	4.87	No	Yes	0	7	8
109	R:R:F208	R:R:F289	8.57	No	No	0	7	6
110	R:R:F208	R:R:I290	2.51	No	No	0	7	8
111	R:R:T210	R:R:Y397	8.74	No	No	0	9	9
112	R:R:A211	R:R:Y294	4	No	Yes	0	8	9
113	R:R:D213	R:R:Y224	8.05	No	No	0	9	7
114	R:R:R214	R:R:Y294	4.12	No	Yes	0	9	9
115	R:R:H219	R:R:Y215	16.33	No	Yes	9	6	8
116	R:R:Y215	R:R:Y296	8.94	Yes	Yes	9	8	4
117	R:R:S217	R:R:Y224	5.09	No	No	0	8	7
118	R:R:H219	R:R:R220	6.77	No	No	0	6	5
119	R:R:H219	R:R:Y296	11.98	No	Yes	9	6	4
120	R:R:P231	R:R:T229	5.25	No	No	0	4	8
121	R:R:K232	R:R:T229	3	No	No	0	5	8
122	R:R:F237	R:R:W241	8.02	No	Yes	6	8	9
123	R:R:I243	R:R:L239	2.85	No	No	0	5	3
124	R:R:V246	R:R:V249	3.21	No	No	0	3	5
125	R:R:I247	R:R:Y275	8.46	No	Yes	0	5	7
126	R:R:F278	R:R:I247	2.51	No	No	0	6	5
127	R:R:L250	R:R:Y275	9.38	No	Yes	0	5	7
128	R:R:F278	R:R:L250	4.87	No	No	0	6	5
129	R:R:P251	R:R:Y275	9.74	No	Yes	0	6	7
130	R:R:D266	R:R:M371	19.41	No	No	4	4	1
131	R:R:D266	R:R:K376	6.91	No	Yes	4	4	2
132	R:R:F268	R:R:I267	10.05	Yes	Yes	0	5	4
133	R:R:D366	R:R:I267	7	No	Yes	0	4	4
134	R:R:I267	R:R:K376	4.36	Yes	Yes	0	4	2
135	R:R:F379	R:R:I267	5.02	Yes	Yes	0	4	4
136	R:R:F268	R:R:I271	10.05	Yes	Yes	1	5	3
137	R:R:F268	R:R:L276	7.31	Yes	No	1	5	5
138	L:L:?1	R:R:F268	15.32	Yes	Yes	1	0	5
139	R:R:H270	R:R:P269	4.58	No	No	1	3	3
140	R:R:I271	R:R:Y275	3.63	Yes	Yes	1	3	7
141	L:L:?1	R:R:I271	3.17	Yes	Yes	1	0	3
142	R:R:D272	R:R:E273	2.6	No	No	0	5	3
143	L:L:?1	R:R:Y275	5.2	Yes	Yes	1	0	7
144	L:L:?1	R:R:L276	4.1	Yes	No	1	0	5
145	R:R:M277	R:R:V367	6.09	No	No	0	4	4
146	R:R:T283	R:R:W279	7.28	No	No	0	8	6
147	L:L:?1	R:R:W279	16.01	Yes	No	0	0	6
148	R:R:I280	R:R:L360	4.28	No	No	0	5	7
149	R:R:I280	R:R:V364	3.07	No	No	0	5	6
150	R:R:L360	R:R:T283	2.95	No	No	0	7	8
151	R:R:L287	R:R:L352	5.54	No	No	0	6	9
152	R:R:F289	R:R:L288	3.65	No	No	0	6	4
153	R:R:I290	R:R:L352	4.28	No	No	0	8	9
154	R:R:L349	R:R:V291	4.47	Yes	No	0	8	5
155	R:R:I353	R:R:V291	3.07	No	No	0	6	5
156	R:R:Y292	R:R:Y296	6.95	No	Yes	0	4	4
157	R:R:L345	R:R:Y294	11.72	Yes	Yes	0	8	9
158	R:R:I348	R:R:Y294	10.88	No	Yes	8	8	9
159	R:R:L349	R:R:Y294	4.69	Yes	Yes	8	8	9
160	R:R:L349	R:R:M295	4.24	Yes	No	0	8	3
161	R:R:K300	R:R:Y296	10.75	No	Yes	0	5	4
162	R:R:I297	R:R:L345	2.85	No	Yes	0	9	8
163	R:R:A342	R:R:L298	4.73	No	No	0	7	6
164	R:R:K300	R:R:W299	4.64	No	No	0	5	3
165	R:R:H302	R:R:V306	4.15	No	No	0	5	5
166	R:R:D338	R:R:H302	16.39	No	No	0	7	5
167	R:R:H304	R:R:M308	3.94	No	No	0	7	7
168	R:R:H304	R:R:M337	3.94	No	No	0	7	6
169	R:R:I309	R:R:T313	4.56	No	No	0	4	3
170	R:R:R336	R:R:R340	7.46	No	No	0	4	7
171	R:R:D338	R:R:I339	7	No	No	0	7	5
172	R:R:I339	R:R:R340	7.52	No	No	0	5	7
173	R:R:K343	R:R:R340	17.33	No	No	0	7	7
174	R:R:R400	R:R:T344	10.35	No	No	0	7	8
175	R:R:I396	R:R:L347	4.28	No	No	0	9	7
176	R:R:I348	R:R:L349	2.85	No	Yes	8	8	8
177	R:R:I348	R:R:I396	4.42	No	No	0	8	9
178	R:R:V351	R:R:V392	4.81	No	No	0	6	6
179	R:R:I353	R:R:L352	4.28	No	No	0	6	9
180	R:R:C355	R:R:W356	2.61	No	Yes	2	8	8
181	R:R:C355	R:R:N389	7.87	No	No	2	8	9
182	R:R:C386	R:R:W356	3.92	No	Yes	0	7	8
183	R:R:N389	R:R:W356	12.43	No	Yes	2	9	8
184	R:R:G357	R:R:P358	4.06	No	No	0	5	9
185	R:R:L385	R:R:P358	4.93	No	No	0	7	9
186	R:R:L359	R:R:L385	2.77	No	No	0	7	7
187	R:R:F379	R:R:I362	10.05	Yes	No	0	4	4
188	R:R:F379	R:R:M363	3.73	Yes	No	0	4	6
189	R:R:F368	R:R:V364	7.87	No	No	0	5	6
190	R:R:D366	R:R:I375	2.8	No	No	0	4	3
191	R:R:K376	R:R:M371	4.32	Yes	No	4	2	1
192	R:R:K373	R:R:N372	2.8	No	No	0	3	1
193	R:R:F381	R:R:T377	2.59	No	No	5	4	1
194	R:R:F381	R:R:V378	3.93	No	No	0	4	4
195	R:R:C382	R:R:F379	2.79	No	Yes	0	5	4
196	L:L:?1	R:R:S383	5.55	Yes	No	1	0	6
197	R:R:L387	R:R:M384	4.24	Yes	Yes	3	7	5
198	R:R:N389	R:R:N393	6.81	No	Yes	2	9	9
199	R:R:D403	R:R:S401	2.94	No	No	0	6	8
200	R:R:D403	R:R:K402	17.97	No	No	0	6	5
201	R:R:F408	R:R:L404	3.65	No	No	0	7	8
202	R:R:H406	R:R:S410	8.37	No	No	0	4	3
203	R:R:F379	R:R:L359	2.44	Yes	No	0	4	7
204	R:R:I216	R:R:Y215	2.42	No	Yes	0	5	8
205	R:R:I375	R:R:Y365	2.42	No	No	0	3	4
206	R:R:G194	R:R:G195	2.11	No	No	0	6	4
207	R:R:A160	R:R:G157	1.95	No	No	0	9	6
208	R:R:G281	R:R:S284	1.86	No	No	0	3	5
209	R:R:G194	R:R:T197	1.82	No	No	0	6	6
210	R:R:G312	R:R:T313	1.82	No	No	0	4	3
211	R:R:A202	R:R:A244	1.79	No	No	0	7	8
212	R:R:P394	R:R:V137	1.77	No	No	0	9	9
213	R:R:G157	R:R:I156	1.76	No	No	0	6	8
214	R:R:G281	R:R:I280	1.76	No	No	0	3	5
215	R:R:G205	R:R:M240	1.75	No	No	0	5	6
216	R:R:G369	R:R:K370	1.74	No	No	0	3	1
217	R:R:G205	R:R:L286	1.71	No	Yes	0	5	8
218	R:R:A398	R:R:V137	1.7	No	No	0	7	9
219	R:R:A244	R:R:T201	1.68	No	No	0	8	6
220	R:R:A120	R:R:I175	1.62	No	No	0	5	5
221	R:R:S123	R:R:V171	1.62	No	No	0	7	7
222	R:R:C139	R:R:M411	1.62	No	No	0	4	5
223	R:R:A198	R:R:I245	1.62	No	No	0	5	4
224	R:R:A301	R:R:M337	1.61	No	No	0	8	6
225	R:R:V346	R:R:V350	1.6	No	No	0	6	6
226	R:R:T125	R:R:V121	1.59	No	No	0	4	4
227	R:R:T283	R:R:V282	1.59	No	No	0	8	6
228	R:R:C355	R:R:L388	1.59	No	No	0	8	5
229	R:R:A236	R:R:L209	1.58	No	No	0	5	6
230	R:R:A301	R:R:L341	1.58	No	Yes	0	8	8
231	R:R:I218	R:R:S217	1.55	No	No	0	9	8
232	R:R:I175	R:R:V179	1.54	No	No	0	5	4
233	R:R:I216	R:R:V228	1.54	No	No	0	5	6
234	R:R:I227	R:R:V228	1.54	No	No	0	4	6
235	R:R:A301	R:R:D338	1.54	No	No	0	8	7
236	R:R:I396	R:R:V351	1.54	No	No	0	9	6
237	R:R:K300	R:R:S303	1.53	No	No	0	5	5
238	R:R:I243	R:R:T242	1.52	No	No	0	5	4
239	R:R:L209	R:R:S206	1.5	No	No	0	6	8
240	R:R:G312	R:R:R311	1.5	No	No	0	4	5
241	R:R:L276	R:R:V367	1.49	No	No	0	5	4
242	R:R:L286	R:R:V285	1.49	Yes	No	0	8	6
243	R:R:I218	R:R:I297	1.47	No	No	10	9	9
244	R:R:L250	R:R:T274	1.47	No	No	0	5	5
245	R:R:L345	R:R:T344	1.47	Yes	No	0	8	8
246	R:R:G369	R:R:Y365	1.45	No	No	0	3	4
247	R:R:P221	R:R:R220	1.44	No	No	0	8	5
248	R:R:P231	R:R:R230	1.44	No	Yes	0	4	1
249	R:R:I218	R:R:L341	1.43	No	Yes	10	9	8
250	R:R:I297	R:R:L341	1.43	No	Yes	10	9	8
251	R:R:I375	R:R:N372	1.42	No	No	0	3	1
252	R:R:C238	R:R:F237	1.4	No	No	0	4	8
253	R:R:A223	R:R:R220	1.38	No	No	0	5	5
254	R:R:A223	R:R:R226	1.38	No	No	0	5	4
255	R:R:L298	R:R:L341	1.38	No	Yes	0	6	8
256	R:R:L298	R:R:L345	1.38	No	Yes	0	6	8
257	R:R:I119	R:R:Q115	1.37	No	Yes	0	5	2
258	R:R:E133	R:R:L132	1.33	No	No	0	8	3
259	R:R:A293	R:R:Y215	1.33	No	Yes	0	7	8
260	R:R:A293	R:R:Y294	1.33	No	Yes	0	7	9
261	R:R:F129	R:R:T128	1.3	No	No	0	4	5
262	R:R:F129	R:R:T391	1.3	No	No	0	4	7
263	R:R:I212	R:R:Y215	1.21	No	Yes	0	7	8
264	R:R:L399	R:R:R405	1.21	No	No	0	5	8
265	R:R:K225	R:R:Y224	1.19	No	No	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Q115	7.125	4	5	2
2	R:R:T130	5.878	5	3	7
3	R:R:Y153	6.0425	4	0	9
4	R:R:L159	5.6525	4	2	9
5	R:R:D163	5.912	5	2	9
6	R:R:F170	5.026	5	1	7
7	R:R:F174	4.6275	4	1	5
8	R:R:F177	5.665	4	1	4
9	R:R:F189	6.13333	6	1	9
10	R:R:F200	4.6775	4	1	7
11	R:R:Y215	6.046	5	9	8
12	R:R:R230	5.7975	4	0	1
13	R:R:W241	4.872	5	6	9
14	R:R:I267	6.6075	4	0	4
15	R:R:F268	10.6825	4	1	5
16	R:R:I271	4.925	4	1	3
17	R:R:Y275	7.282	5	1	7
18	R:R:L286	3.5075	4	0	8
19	R:R:Y294	6.12333	6	8	9
20	R:R:Y296	9.655	4	9	4
21	R:R:L341	1.455	4	10	8
22	R:R:L345	4.355	4	0	8
23	R:R:L349	4.0625	4	8	8
24	R:R:W356	5.965	4	2	8
25	R:R:K376	5.035	4	4	2
26	R:R:F379	4.806	5	0	4
27	R:R:M384	4.36	4	3	5
28	R:R:L387	5.314	5	3	7
29	R:R:N393	5.12	4	2	9
30	L:L:?1	7.10375	16	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F268	R:R:I267	27.9847	10.05	Yes	Yes	0	5	4
2	L:L:?1	R:R:F268	27.6083	15.32	Yes	Yes	1	0	5
3	L:L:?1	R:R:F189	23.7822	2.7	Yes	Yes	1	0	9
4	R:R:D184	R:R:F189	18.1078	3.58	No	Yes	0	2	9
5	R:R:D184	R:R:R182	12.7367	3.57	No	No	0	2	4
6	R:R:D176	R:R:R182	11.3658	4.76	No	No	0	3	4
7	L:L:?1	R:R:F174	13.8098	3.6	Yes	Yes	1	0	5
8	R:R:F174	R:R:I119	19.546	3.77	Yes	No	0	5	5
9	R:R:I119	R:R:Q115	17.1414	1.37	No	Yes	0	5	2
10	L:L:?1	R:R:F200	84.1676	2.7	Yes	Yes	1	0	7
11	R:R:C386	R:R:F200	99.6236	9.78	No	Yes	0	7	7
12	R:R:C386	R:R:W356	100	3.92	No	Yes	0	7	8
13	R:R:N389	R:R:W356	70.7343	12.43	No	Yes	2	9	8
14	R:R:N389	R:R:N393	71.1444	6.81	No	Yes	2	9	9
15	R:R:D163	R:R:N393	37.4122	2.69	Yes	Yes	2	9	9
16	R:R:D163	R:R:N134	22.6361	8.08	Yes	No	0	9	9
17	R:R:N134	R:R:T130	21.3945	4.39	No	Yes	0	9	7
18	R:R:L387	R:R:T130	21.5686	5.9	Yes	Yes	3	7	7
19	R:R:D163	R:R:S390	22.6361	8.83	Yes	No	0	9	9
20	R:R:S390	R:R:T130	21.3945	7.99	No	Yes	0	9	7
21	R:R:L387	R:R:M384	10.9163	4.24	Yes	Yes	3	7	5
22	R:R:S167	R:R:T130	10.7815	6.4	No	Yes	3	7	7
23	R:R:A160	R:R:L138	31.9231	6.3	No	No	0	9	7
24	R:R:L138	R:R:V161	32.3838	2.98	No	No	0	7	6
25	R:R:V161	R:R:W241	32.8445	3.68	No	Yes	0	6	9
26	R:R:S158	R:R:W241	33.9851	6.18	No	Yes	6	9	9
27	R:R:S158	R:R:S206	36.6257	6.52	No	No	0	9	8
28	R:R:L159	R:R:S206	40.109	7.51	Yes	No	0	9	8
29	R:R:L159	R:R:N393	30.7264	5.49	Yes	Yes	2	9	9
30	R:R:L404	R:R:Y153	10.2365	10.55	No	Yes	0	8	9
31	R:R:I156	R:R:Y153	27.4791	3.63	No	Yes	0	8	9
32	R:R:G157	R:R:I156	27.9847	1.76	No	No	0	6	8
33	R:R:A160	R:R:G157	28.5016	1.95	No	No	0	9	6
34	R:R:P151	R:R:R230	14.4278	5.76	No	Yes	0	5	1
35	R:R:P151	R:R:R150	21.136	2.88	No	No	0	5	5
36	R:R:R150	R:R:Y153	21.7091	6.17	No	Yes	0	5	9
37	R:R:P151	R:R:V228	20.827	3.53	No	No	0	5	6
38	R:R:I216	R:R:V228	21.8158	1.54	No	No	0	5	6
39	R:R:I216	R:R:Y215	22.3777	2.42	No	Yes	0	5	8
40	R:R:A293	R:R:Y215	33.367	1.33	No	Yes	0	7	8
41	R:R:A293	R:R:Y294	34.2379	1.33	No	Yes	0	7	9
42	R:R:L349	R:R:Y294	57.6156	4.69	Yes	Yes	8	8	9
43	R:R:L349	R:R:V291	63.2788	4.47	Yes	No	0	8	5
44	R:R:I353	R:R:V291	63.7395	3.07	No	No	0	6	5
45	R:R:I353	R:R:L352	64.2002	4.28	No	No	0	6	9
46	R:R:I290	R:R:L352	65.1778	4.28	No	No	0	8	9
47	R:R:F208	R:R:I290	65.6947	2.51	No	No	0	7	8
48	R:R:F208	R:R:L286	67.2116	4.87	No	Yes	0	7	8
49	R:R:L286	R:R:V204	69.3466	5.96	Yes	No	0	8	7
50	R:R:V204	R:R:W356	69.9197	4.9	No	Yes	0	7	8
51	R:R:I297	R:R:L345	24.9452	2.85	No	Yes	0	9	8
52	R:R:L345	R:R:Y294	46.7723	11.72	Yes	Yes	0	8	9
53	L:L:?1	R:R:Y275	11.849	5.2	Yes	Yes	1	0	7
54	R:R:D366	R:R:I267	10.4556	7	No	Yes	0	4	4
55	R:R:F379	R:R:I267	11.4557	5.02	Yes	Yes	0	4	4
56	L:L:?1	R:R:W279	12.6805	16.01	Yes	No	0	0	6
57	R:R:T283	R:R:W279	11.4557	7.28	No	No	0	8	6
58	R:R:L298	R:R:L345	18.5516	1.38	No	Yes	0	6	8
59	R:R:A301	R:R:D338	19.1078	1.54	No	No	0	8	7
60	R:R:A301	R:R:L341	29.7545	1.58	No	Yes	0	8	8
61	R:R:I297	R:R:L341	15.9672	1.43	No	Yes	10	9	8
62	R:R:L298	R:R:L341	16.0908	1.38	No	Yes	0	6	8
63	R:R:D338	R:R:I339	10.9838	7	No	No	0	7	5
64	R:R:F170	R:R:F200	13.7255	3.22	Yes	Yes	1	7	7
65	R:R:F170	R:R:F174	10.0455	3.22	Yes	Yes	1	7	5
66	R:R:D163	R:R:L159	10.1073	4.07	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F174	R:R:I119	3.77	1	Yes	No	5	5	1	2
R:R:F200	R:R:G166	3.01	1	Yes	No	7	8	1	2
R:R:I169	R:R:V196	3.07	0	No	No	5	7	2	1
R:R:F170	R:R:F174	3.22	1	Yes	Yes	7	5	1	1
R:R:F170	R:R:V196	5.24	1	Yes	No	7	7	1	1
R:R:F170	R:R:F200	3.22	1	Yes	Yes	7	7	1	1
R:R:F170	R:R:S383	2.64	1	Yes	No	7	6	1	1
L:L:?1	R:R:F170	10.81	1	Yes	Yes	0	7	0	1
R:R:K192	R:R:S173	6.12	1	No	No	6	4	1	1
L:L:?1	R:R:S173	10	1	Yes	No	0	4	0	1
R:R:F174	R:R:H178	7.92	1	Yes	No	5	4	1	2
L:L:?1	R:R:F174	3.6	1	Yes	Yes	0	5	0	1
R:R:F177	R:R:H178	7.92	1	Yes	No	4	4	1	2
R:R:F177	R:R:F189	5.36	1	Yes	Yes	4	9	1	1
R:R:F177	R:R:P269	5.78	1	Yes	No	4	3	1	2
L:L:?1	R:R:F177	3.6	1	Yes	Yes	0	4	0	1
R:R:D184	R:R:F189	3.58	0	No	Yes	2	9	2	1
R:R:F189	R:R:L193	4.87	1	Yes	No	9	4	1	1
R:R:F189	R:R:P269	10.11	1	Yes	No	9	3	1	2
R:R:F189	R:R:H270	10.18	1	Yes	No	9	3	1	2
L:L:?1	R:R:F189	2.7	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:K192	4.17	1	Yes	No	0	6	0	1
R:R:I271	R:R:L193	2.85	1	Yes	No	3	4	1	1
L:L:?1	R:R:L193	9.22	1	Yes	No	0	4	0	1
L:L:?1	R:R:V196	5.51	1	Yes	No	0	7	0	1
R:R:I247	R:R:T197	3.04	0	No	No	5	6	2	1
L:L:?1	R:R:T197	12	1	Yes	No	0	6	0	1
R:R:C386	R:R:F200	9.78	0	No	Yes	7	7	2	1
L:L:?1	R:R:F200	2.7	1	Yes	Yes	0	7	0	1
R:R:I247	R:R:Y275	8.46	0	No	Yes	5	7	2	1
R:R:L250	R:R:Y275	9.38	0	No	Yes	5	7	2	1
R:R:P251	R:R:Y275	9.74	0	No	Yes	6	7	2	1
R:R:F268	R:R:I267	10.05	1	Yes	Yes	5	4	1	2
R:R:F268	R:R:I271	10.05	1	Yes	Yes	5	3	1	1
R:R:F268	R:R:L276	7.31	1	Yes	No	5	5	1	1
L:L:?1	R:R:F268	15.32	1	Yes	Yes	0	5	0	1
R:R:H270	R:R:P269	4.58	1	No	No	3	3	2	2
R:R:I271	R:R:Y275	3.63	1	Yes	Yes	3	7	1	1
L:L:?1	R:R:I271	3.17	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:Y275	5.2	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:L276	4.1	1	Yes	No	0	5	0	1
R:R:T283	R:R:W279	7.28	0	No	No	8	6	2	1
L:L:?1	R:R:W279	16.01	1	Yes	No	0	6	0	1
L:L:?1	R:R:S383	5.55	1	Yes	No	0	6	0	1
R:R:G194	R:R:T197	1.82	0	No	No	6	6	2	1
R:R:L276	R:R:V367	1.49	1	No	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8GAG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.51
Number of Linked Nodes	243
Number of Links	265
Number of Hubs	30
Number of Links mediated by Hubs	120
Number of Communities	10
Number of Nodes involved in Communities	51
Number of Links involved in Communities	67

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	34424
Length Of Smallest Path	3
Average Path Length	14.9224
Length of Longest Path	30
Minimum Path Strength	1.27
Average Path Strength	5.30899
Maximum Path Strength	14.38
Minimum Path Correlation	0.7
Average Path Correlation	0.929066
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	51.7994
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.5027
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	YVF
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	YVF
Name	methyl (2R)-2-({(1M)-5-methyl-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonyl}amino)-2-(thiophen-2-yl)propanoate
Synonyms
Identifier
Formula	C20 H18 F3 N3 O3 S
Molecular Weight	437.435
SMILES
PubChem	170838490
Formal Charge	0
Total Atoms	48
Total Chiral Atoms	1
Total Bonds	50
Total Aromatic Bonds	16


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21554
Sequence	>8GAG_nogp_Chain_R F M V L N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I R C R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V F H R K D S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R P L A Y K R I V T R P K A V V A F C L M W T I A I V I A V L P L L D I F P H I D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G T A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G K M N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D L R H A F R S M Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5TGZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM6538	-	-	2.8	2016-11-02	doi.org/10.1016/j.cell.2016.10.004
	5U09	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Taranabant	-	-	2.6	2016-12-07	doi.org/10.1038/nature20613
	5XR8	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM12033	-	-	2.95	2017-07-12	doi.org/10.1038/nature23272
	5XRA	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM11542	-	-	2.8	2017-07-12	doi.org/10.1038/nature23272
	6N4B	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-	Gi1/β1/γ2	3	2019-01-30	doi.org/10.1016/j.cell.2018.11.040
	6N4B (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-		3	2019-01-30	doi.org/10.1016/j.cell.2018.11.040
	6KQI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	Org27569	-	3.25	2019-10-23	doi.org/10.1038/s41589-019-0387-2
	6KPG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	Gi1/β1/γ2	3	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-		3	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	7V3Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	-	-	3.29	2021-11-24	doi.org/10.1021/jacs.1c06847
	7FEE	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	-	2.7	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	7WV9	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	Gi2/β1/γ2	3.36	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	7WV9 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011		3.36	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	8GHV	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-	Gi1/β1/γ2	2.8	2023-05-24	doi.org/10.1038/s41467-023-37864-4
	8GHV (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-		2.8	2023-05-24	doi.org/10.1038/s41467-023-37864-4
	8IKG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	PubChem 703205	Gi1/β1/γ1	3.4	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	PubChem 703205		3.4	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKH	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	PubChem 171393541	Gi1/β1/γ1	3.3	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKH (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	PubChem 171393541		3.3	2024-06-05	doi.org/10.1073/pnas.2321532121
	9ERX	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-	Gi1/β1/γ2	2.9	2024-06-26	doi.org/10.21203/rs.3.rs-4277209/v1
	9ERX (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-		2.9	2024-06-26	doi.org/10.21203/rs.3.rs-4277209/v1
	9B9Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MRI-1867	-	-	3.3	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9BA0	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MRI-1891	-	-	3.13	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9B54	A	Lipid	Cannabinoid	CB₁	Homo sapiens	VIP36	-	Gi1/β1/γ2	2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B54 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	VIP36	-		2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B65	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-	Gi1/β1/γ2	3.03	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B65 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-		3.03	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	8K8J	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-	chim(Gs-CtGq)/β1/γ2	2.88	2024-02-14	doi.org/10.1002/advs.202306311
	8K8J (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-		2.88	2024-02-14	doi.org/10.1002/advs.202306311
	8GAG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Z8526711350	-	Gi1/β1/γ2	3.3	2024-02-28	To be published
	8GAG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Z8526711350	-		3.3	2024-02-28	To be published
	8WRZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	Arrestin2	3.6	2024-02-28	AM841
	8WU1	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-	Arrestin2	3.2	2024-03-20	doi.org/10.1016/j.cell.2023.11.017
	9B9Y	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Taranabant	-	-	3.5	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9DGI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Z8526711350	-	-	3.35	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	9EGO	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Z8526711350	-	Gi1/β1/γ2	3.2	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	9EGO (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Z8526711350	-		3.2	2025-04-30	doi.org/10.1038/s41467-025-57136-7

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8GAG_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.