psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F59	R:R:P219	4.33	No	No	0	7	1
2	R:R:A220	R:R:F59	5.55	No	No	0	1	7
3	R:R:A220	R:R:S60	3.42	No	No	0	1	7
4	R:R:D62	R:R:S65	8.83	No	No	0	7	5
5	R:R:D62	R:R:Q319	5.22	No	No	0	7	4
6	R:R:F64	R:R:Y323	5.16	No	Yes	0	2	4
7	R:R:S65	R:R:Y323	11.45	No	Yes	0	5	4
8	R:R:V68	R:R:Y323	7.57	No	Yes	0	4	4
9	R:R:L69	R:R:N139	6.87	No	Yes	1	4	5
10	R:R:D228	R:R:L69	4.07	Yes	No	1	4	4
11	R:R:L69	R:R:Y323	3.52	No	Yes	0	4	4
12	R:R:K72	R:R:V76	4.55	No	No	0	2	4
13	R:R:F77	R:R:L73	4.87	No	No	0	4	3
14	R:R:N139	R:R:T74	10.24	Yes	No	0	5	4
15	R:R:F77	R:R:V81	5.24	No	No	0	4	6
16	R:R:L78	R:R:Y82	4.69	No	Yes	1	5	7
17	R:R:H135	R:R:L78	9	Yes	No	1	5	5
18	R:R:I327	R:R:L78	4.28	No	No	0	4	5
19	R:R:H135	R:R:P79	4.58	Yes	No	0	5	5
20	R:R:I136	R:R:P79	5.08	No	No	0	4	5
21	R:R:C331	R:R:V81	3.42	No	No	0	6	6
22	R:R:F128	R:R:Y82	6.19	Yes	Yes	1	8	7
23	R:R:K131	R:R:Y82	16.72	No	Yes	1	7	7
24	R:R:H135	R:R:Y82	4.36	Yes	Yes	1	5	7
25	R:R:C331	R:R:Y82	9.41	No	Yes	0	6	7
26	R:R:T334	R:R:Y82	4.99	No	Yes	1	7	7
27	R:R:I132	R:R:T83	7.6	No	No	0	7	5
28	R:R:C338	R:R:V85	5.12	No	No	0	7	8
29	R:R:F86	R:R:L90	6.09	Yes	Yes	1	6	6
30	R:R:F86	R:R:V125	5.24	Yes	No	1	6	6
31	R:R:F128	R:R:F86	4.29	Yes	Yes	1	8	6
32	R:R:F86	R:R:P129	10.11	Yes	No	0	6	8
33	R:R:C338	R:R:V88	5.12	No	No	0	7	6
34	R:R:A89	R:R:S337	3.42	No	No	0	8	9
35	R:R:L90	R:R:P91	3.28	Yes	No	0	6	5
36	R:R:L90	R:R:V125	4.47	Yes	No	1	6	6
37	R:R:P341	R:R:S92	7.13	No	No	0	9	7
38	R:R:D121	R:R:N93	14.81	Yes	No	2	9	9
39	R:R:N93	R:R:P341	8.15	No	No	0	9	9
40	R:R:N93	R:R:Y344	6.98	No	Yes	2	9	9
41	R:R:G94	R:R:L122	3.42	No	No	0	4	8
42	R:R:F351	R:R:M95	3.73	No	No	0	8	6
43	R:R:A96	R:R:Y344	4	No	Yes	2	9	9
44	R:R:A96	R:R:F351	4.16	No	No	2	9	8
45	R:R:L101	R:R:L97	5.54	No	No	0	4	7
46	R:R:F102	R:R:W98	6.01	No	No	0	4	3
47	R:R:R103	R:R:W98	16.99	No	No	6	5	3
48	R:R:H354	R:R:W98	6.35	Yes	No	6	5	3
49	R:R:R103	R:R:V99	3.92	No	No	6	5	8
50	R:R:H354	R:R:V99	11.07	Yes	No	6	5	8
51	R:R:F100	R:R:V111	5.24	Yes	No	0	6	7
52	R:R:F100	R:R:M114	7.46	Yes	Yes	2	6	8
53	R:R:A115	R:R:F100	4.16	No	Yes	0	7	6
54	R:R:F100	R:R:Y344	5.16	Yes	Yes	2	6	9
55	R:R:F100	R:R:S348	6.61	Yes	No	2	6	8
56	R:R:F102	R:R:L101	7.31	No	No	0	4	4
57	R:R:H354	R:R:R103	9.03	Yes	No	6	5	5
58	R:R:T104	R:R:V111	7.93	No	No	0	6	7
59	R:R:D350	R:R:T104	8.67	No	No	0	6	6
60	R:R:H349	R:R:K106	6.55	No	No	0	5	7
61	R:R:D350	R:R:K106	8.3	No	No	0	6	7
62	R:R:P109	R:R:Q172	11.05	No	Yes	0	7	8
63	R:R:A191	R:R:P109	3.74	No	No	0	8	7
64	R:R:A191	R:R:I112	4.87	No	No	0	8	6
65	R:R:I112	R:R:I192	4.42	No	No	0	6	3
66	R:R:C168	R:R:Y113	10.75	No	Yes	0	7	7
67	R:R:L169	R:R:Y113	3.52	No	Yes	0	8	7
68	R:R:Q172	R:R:Y113	3.38	Yes	Yes	0	8	7
69	R:R:A191	R:R:Y113	4	No	Yes	0	8	7
70	R:R:I194	R:R:Y113	4.84	No	Yes	0	5	7
71	R:R:L169	R:R:M114	4.24	No	Yes	0	8	8
72	R:R:M114	R:R:Y344	7.18	Yes	Yes	2	8	9
73	R:R:M114	R:R:V347	6.09	Yes	Yes	0	8	7
74	R:R:M114	R:R:S348	4.6	Yes	No	2	8	8
75	R:R:F165	R:R:N116	14.5	Yes	No	3	7	9
76	R:R:N116	R:R:S195	8.94	No	No	3	9	7
77	R:R:N116	R:R:W199	13.56	No	Yes	3	9	9
78	R:R:D340	R:R:L117	12.21	Yes	No	2	9	9
79	R:R:L117	R:R:Y344	10.55	No	Yes	2	9	9
80	R:R:A118	R:R:Y344	4	No	Yes	0	8	9
81	R:R:L119	R:R:L123	6.92	No	No	0	6	7
82	R:R:L119	R:R:W199	6.83	No	Yes	0	6	9
83	R:R:A120	R:R:N158	4.69	No	Yes	0	8	8
84	R:R:D121	R:R:N158	5.39	Yes	Yes	2	9	8
85	R:R:D121	R:R:S337	5.89	Yes	No	0	9	9
86	R:R:D121	R:R:D340	10.65	Yes	Yes	2	9	9
87	R:R:D121	R:R:Y344	3.45	Yes	Yes	2	9	9
88	I:I:?1	R:R:D121	10.74	Yes	Yes	2	0	9
89	R:R:F154	R:R:L123	3.65	No	No	3	5	7
90	R:R:L123	W:W:?1	14.18	No	Yes	3	7	0
91	R:R:N158	R:R:S124	4.47	Yes	No	0	8	7
92	R:R:V150	R:R:W127	3.68	No	No	0	5	7
93	R:R:L151	R:R:W127	7.97	No	No	0	5	7
94	R:R:F154	R:R:W127	7.02	No	No	0	5	7
95	R:R:F128	R:R:K131	4.96	Yes	No	1	8	7
96	R:R:F128	R:R:T334	6.49	Yes	No	1	8	7
97	R:R:L130	R:R:Y143	4.69	No	Yes	0	7	7
98	R:R:H135	R:R:Y134	10.89	Yes	Yes	1	5	5
99	R:R:N139	R:R:Y134	10.47	Yes	Yes	1	5	5
100	R:R:W141	R:R:Y134	8.68	Yes	Yes	1	9	5
101	R:R:T225	R:R:Y134	3.75	No	Yes	1	4	5
102	R:R:C226	R:R:Y134	4.03	No	Yes	1	9	5
103	R:R:D228	R:R:Y134	6.9	Yes	Yes	1	4	5
104	R:R:H135	R:R:N139	6.38	Yes	Yes	1	5	5
105	R:R:D228	R:R:N139	4.04	Yes	Yes	1	4	5
106	R:R:I142	R:R:N140	4.25	No	No	0	1	4
107	R:R:I223	R:R:N140	8.5	No	No	0	3	4
108	R:R:W141	R:R:Y143	15.43	Yes	Yes	0	9	7
109	R:R:C148	R:R:W141	6.53	No	Yes	1	9	9
110	R:R:L151	R:R:W141	4.56	No	Yes	0	5	9
111	R:R:C226	R:R:W141	7.84	No	Yes	1	9	9
112	R:R:I142	R:R:Y143	7.25	No	Yes	0	1	7
113	R:R:E145	R:R:K213	10.8	No	No	1	3	5
114	R:R:E145	R:R:T215	9.88	No	No	1	3	4
115	R:R:L147	R:R:V150	4.47	No	No	0	6	5
116	R:R:C148	R:R:T215	3.38	No	No	1	9	4
117	R:R:C148	R:R:C226	7.28	No	No	1	9	9
118	R:R:N149	R:R:Q214	6.6	No	No	0	6	4
119	R:R:I152	R:R:Q214	6.86	No	No	0	5	4
120	R:R:H227	R:R:I152	9.28	Yes	No	0	5	5
121	R:R:G153	R:R:Y210	5.79	No	No	0	6	5
122	R:R:F154	W:W:?1	13.36	No	Yes	3	5	0
123	R:R:F155	R:R:Y156	13.41	No	Yes	0	6	5
124	R:R:F155	R:R:L330	4.87	No	No	0	6	5
125	R:R:L209	R:R:Y156	3.52	No	Yes	0	4	5
126	R:R:H227	R:R:Y156	7.62	Yes	Yes	0	5	5
127	R:R:F243	R:R:Y156	8.25	Yes	Yes	0	6	5
128	R:R:A157	W:W:?1	10.37	No	Yes	0	5	0
129	R:R:N158	R:R:S162	5.96	Yes	No	2	8	9
130	R:R:N158	R:R:N336	8.17	Yes	Yes	2	8	9
131	I:I:?1	R:R:N158	8.15	Yes	Yes	2	0	8
132	R:R:M159	R:R:Y160	7.18	No	Yes	4	7	7
133	R:R:L246	R:R:Y160	11.72	No	Yes	4	5	7
134	R:R:V250	R:R:Y160	6.31	No	Yes	4	5	7
135	R:R:N304	R:R:Y160	4.65	No	Yes	0	8	7
136	R:R:C161	R:R:F165	4.19	No	Yes	0	7	7
137	R:R:C161	R:R:I202	4.91	No	No	0	7	8
138	R:R:C161	W:W:?1	4.64	No	Yes	0	7	0
139	R:R:N336	R:R:S162	4.47	Yes	No	2	9	9
140	I:I:?1	R:R:S162	5.94	Yes	No	2	0	9
141	R:R:I163	R:R:P254	3.39	No	Yes	0	7	9
142	R:R:I163	R:R:Y296	3.63	No	Yes	7	7	9
143	R:R:F300	R:R:I163	13.82	No	No	7	9	7
144	R:R:I198	R:R:L164	4.28	No	No	0	7	6
145	R:R:L164	R:R:V250	4.47	No	No	0	6	5
146	R:R:L164	R:R:P254	3.28	No	Yes	0	6	9
147	R:R:F165	R:R:S195	5.28	Yes	No	3	7	7
148	R:R:F165	R:R:I198	8.79	Yes	No	0	7	7
149	R:R:F165	R:R:W199	6.01	Yes	Yes	3	7	9
150	R:R:L166	R:R:V292	4.47	No	No	0	8	8
151	R:R:P254	R:R:T167	3.5	Yes	No	0	9	7
152	R:R:T167	R:R:T258	6.28	No	No	0	7	8
153	R:R:S170	R:R:Y262	11.45	No	Yes	0	9	9
154	R:R:E176	R:R:Q172	10.19	No	Yes	0	8	8
155	R:R:K187	R:R:Q172	8.14	No	Yes	0	6	8
156	R:R:K281	R:R:R173	3.71	No	No	0	5	9
157	R:R:R173	R:R:V347	10.46	No	Yes	0	9	7
158	R:R:A174	R:R:M265	4.83	No	No	0	8	8
159	R:R:I177	R:R:L269	5.71	No	No	0	8	8
160	R:R:N179	R:R:V178	4.43	No	No	0	6	7
161	R:R:K187	R:R:M181	4.32	No	No	0	6	5
162	R:R:H183	R:R:K186	7.86	No	No	0	6	7
163	R:R:W199	W:W:?1	20	Yes	Yes	3	9	0
164	R:R:L203	W:W:?1	10.13	No	Yes	0	3	0
165	R:R:T206	R:R:Y210	4.99	No	No	0	7	5
166	R:R:I207	R:R:P208	3.39	No	No	0	4	7
167	R:R:P208	R:R:Y242	8.34	No	Yes	0	7	5
168	R:R:L209	R:R:Y242	10.55	No	Yes	0	4	5
169	R:R:Y210	W:W:?1	18.87	No	Yes	0	5	0
170	R:R:K213	R:R:T215	6.01	No	No	1	5	4
171	R:R:K213	R:R:P231	3.35	No	No	0	5	4
172	R:R:I216	R:R:P231	8.47	No	No	0	1	4
173	R:R:F217	R:R:P219	5.78	No	No	0	1	1
174	R:R:F217	R:R:T224	5.19	No	No	0	1	5
175	R:R:I218	R:R:P219	3.39	No	No	0	4	1
176	R:R:I218	R:R:L221	8.56	No	Yes	0	4	3
177	R:R:I223	R:R:L221	4.28	No	Yes	0	3	3
178	R:R:D228	R:R:T225	4.34	Yes	No	1	4	4
179	R:R:T225	R:R:V229	9.52	No	No	0	4	4
180	R:R:H227	R:R:Y326	5.44	Yes	Yes	5	5	4
181	R:R:H227	R:R:L330	3.86	Yes	No	5	5	5
182	R:R:L230	R:R:P231	4.93	No	No	0	5	4
183	R:R:E232	R:R:L234	9.28	No	No	0	1	5
184	R:R:E232	R:R:L235	5.3	No	No	0	1	4
185	R:R:I314	R:R:V236	7.68	Yes	No	0	2	3
186	R:R:G237	R:R:K315	6.97	No	No	0	1	2
187	R:R:M239	R:R:Y311	7.18	No	No	0	4	5
188	R:R:F240	R:R:N241	4.83	Yes	No	0	3	3
189	R:R:F240	R:R:V308	3.93	Yes	No	0	3	6
190	R:R:F240	R:R:F312	6.43	Yes	No	0	3	3
191	R:R:F240	R:R:K315	6.2	Yes	No	0	3	2
192	R:R:F243	R:R:Y242	12.38	Yes	Yes	0	6	5
193	R:R:L246	R:R:Y242	4.69	No	Yes	0	5	5
194	R:R:F243	R:R:L307	13.4	Yes	No	0	6	5
195	R:R:F243	R:R:Y311	9.28	Yes	No	0	6	5
196	R:R:L246	R:R:V250	4.47	No	No	4	5	5
197	R:R:G249	R:R:I248	3.53	No	No	0	5	4
198	R:R:F251	R:R:L252	4.87	No	No	0	8	4
199	R:R:F251	R:R:T301	6.49	No	No	0	8	5
200	R:R:F251	R:R:N304	16.92	No	No	0	8	8
201	R:R:F253	R:R:P254	4.33	No	Yes	0	6	9
202	R:R:F253	R:R:L257	7.31	No	No	0	6	7
203	R:R:A255	R:R:Y296	4	No	Yes	0	7	9
204	R:R:T258	R:R:Y296	4.99	No	Yes	0	8	9
205	R:R:M265	R:R:Y262	4.79	No	Yes	0	8	9
206	R:R:L288	R:R:Y262	9.38	Yes	Yes	0	8	9
207	R:R:A289	R:R:Y262	5.34	No	Yes	0	8	9
208	R:R:V292	R:R:Y262	7.57	No	Yes	0	8	9
209	R:R:R267	R:R:V263	6.54	No	No	0	4	3
210	R:R:K280	R:R:N277	8.39	No	No	0	4	4
211	R:R:E279	R:R:R282	4.65	No	No	0	3	6
212	R:R:E279	R:R:K283	6.75	No	No	0	3	5
213	R:R:K280	R:R:R284	8.66	No	No	0	4	7
214	R:R:K281	R:R:R284	3.71	No	No	0	5	7
215	R:R:I286	R:R:R282	6.26	No	No	0	6	6
216	R:R:R284	R:R:R352	10.66	No	No	0	7	8
217	R:R:F346	R:R:K287	7.44	Yes	No	0	7	5
218	R:R:F346	R:R:L288	3.65	Yes	Yes	0	7	8
219	R:R:L288	R:R:V347	4.47	Yes	Yes	0	8	7
220	R:R:F300	R:R:M295	4.98	No	Yes	0	9	6
221	R:R:I339	R:R:M295	4.37	No	Yes	0	6	6
222	R:R:D340	R:R:M295	4.16	Yes	Yes	0	9	6
223	R:R:F300	R:R:Y296	12.38	No	Yes	7	9	9
224	R:R:P302	R:R:T301	3.5	No	No	0	9	5
225	R:R:S303	R:R:S333	4.89	No	No	4	7	8
226	R:R:L306	R:R:V322	4.47	No	Yes	0	4	4
227	R:R:L307	R:R:Y326	5.86	No	Yes	0	5	4
228	R:R:V309	R:R:V322	4.81	No	Yes	0	4	4
229	R:R:H310	R:R:Y311	6.53	Yes	No	0	4	5
230	R:R:H310	R:R:I314	6.63	Yes	Yes	5	4	2
231	R:R:H310	R:R:S320	8.37	Yes	No	5	4	2
232	R:R:H310	R:R:Y323	7.62	Yes	Yes	0	4	4
233	R:R:H310	R:R:Y326	31.58	Yes	Yes	5	4	4
234	R:R:F312	R:R:S316	3.96	No	No	0	3	1
235	R:R:L313	R:R:S320	4.5	No	No	0	1	2
236	R:R:H321	R:R:L313	3.86	No	No	0	4	1
237	R:R:I314	R:R:S320	4.64	Yes	No	5	2	2
238	R:R:Q317	R:R:S316	4.33	No	No	0	1	1
239	R:R:H321	R:R:V322	5.54	No	Yes	0	4	4
240	R:R:L325	R:R:V322	4.47	No	Yes	0	5	4
241	R:R:I327	R:R:Y323	7.25	No	Yes	0	4	4
242	R:R:L330	R:R:Y326	7.03	No	Yes	5	5	4
243	R:R:D340	R:R:N336	4.04	Yes	Yes	2	9	9
244	I:I:?1	R:R:N336	8.15	Yes	Yes	2	0	9
245	R:R:D340	R:R:Y344	5.75	Yes	Yes	2	9	9
246	I:I:?1	R:R:D340	8.05	Yes	Yes	2	0	9
247	R:R:F351	R:R:Y344	6.19	No	Yes	2	8	9
248	R:R:F346	R:R:Y345	7.22	Yes	Yes	0	7	7
249	R:R:R352	R:R:Y345	6.17	No	Yes	0	8	7
250	R:R:K356	R:R:Y345	7.17	No	Yes	0	4	7
251	R:R:H349	R:R:R352	6.77	No	No	0	5	8
252	R:R:V211	W:W:?1	3.27	No	Yes	0	3	0
253	R:R:C299	R:R:I298	3.27	No	No	0	9	6
254	R:R:C299	R:R:M295	3.24	No	Yes	0	9	6
255	R:R:S65	R:R:V61	3.23	No	No	0	5	6
256	R:R:A66	R:R:L221	3.15	No	Yes	0	4	3
257	R:R:A118	R:R:L97	3.15	No	No	0	8	7
258	R:R:T74	R:R:T75	3.14	No	No	0	4	5
259	R:R:A247	R:R:N304	3.13	No	No	0	5	8
260	R:R:M159	R:R:S303	3.07	No	No	4	7	7
261	R:R:M159	R:R:S333	3.07	No	No	4	7	8
262	R:R:I202	R:R:V205	3.07	No	No	0	8	5
263	R:R:K315	R:R:V236	3.04	No	No	0	2	3
264	R:R:K72	R:R:T75	3	No	No	0	2	5
265	R:R:L73	R:R:V328	2.98	No	No	0	3	6
266	R:R:L244	R:R:V308	2.98	No	No	0	5	6
267	R:R:L288	R:R:V343	2.98	Yes	No	0	8	8
268	R:R:L332	R:R:V328	2.98	No	No	0	8	6
269	R:R:I132	R:R:I136	2.94	No	No	0	7	4
270	R:R:I190	R:R:I194	2.94	No	No	0	4	5
271	R:R:I266	R:R:I286	2.94	No	No	0	5	6
272	R:R:A133	R:R:H137	2.93	No	No	0	4	4
273	R:R:K283	R:R:K287	2.87	No	No	0	5	5
274	R:R:I248	R:R:L244	2.85	No	No	0	4	5
275	R:R:K281	R:R:L269	2.82	No	No	0	5	8
276	R:R:G144	R:R:W141	2.81	No	Yes	0	8	9
277	R:R:A324	R:R:F64	2.77	No	No	0	1	2
278	R:R:L122	R:R:L97	2.77	No	No	0	8	7
279	R:R:L203	R:R:L204	2.77	No	No	0	3	4
280	R:R:A355	R:R:Y345	2.67	No	Yes	0	7	7
281	R:R:F128	R:R:V85	2.62	Yes	No	0	8	8
282	R:R:F342	R:R:T291	2.59	No	No	0	6	5
283	R:R:F346	R:R:T291	2.59	Yes	No	0	7	5
284	R:R:F256	R:R:L257	2.44	No	No	0	3	7
285	R:R:M181	R:R:W175	2.33	No	No	0	5	5
286	R:R:A108	R:R:P109	1.87	No	No	0	7	7
287	R:R:A329	R:R:P302	1.87	No	No	0	7	9
288	R:R:G138	R:R:T75	1.82	No	No	0	4	5
289	R:R:A174	R:R:A261	1.79	No	No	0	8	7
290	R:R:G193	R:R:I192	1.76	No	No	0	2	3
291	R:R:G318	R:R:I314	1.76	No	Yes	0	1	2
292	R:R:G182	R:R:M181	1.75	No	No	0	4	5
293	R:R:G193	R:R:L196	1.71	No	No	0	2	5
294	R:R:A110	R:R:V347	1.7	No	Yes	0	8	7
295	R:R:A261	R:R:V171	1.7	No	No	0	7	6
296	R:R:N179	R:R:P180	1.63	No	No	0	6	8
297	R:R:S67	R:R:V68	1.62	No	No	0	4	4
298	R:R:A188	R:R:I112	1.62	No	No	0	3	6
299	R:R:A268	R:R:I177	1.62	No	No	0	5	8
300	R:R:A285	R:R:M265	1.61	No	No	0	7	8
301	R:R:V211	R:R:V212	1.6	No	No	0	3	4
302	R:R:T83	R:R:V87	1.59	No	No	0	5	5
303	R:R:G182	R:R:H183	1.59	No	No	0	4	6
304	R:R:C299	R:R:L335	1.59	No	No	0	9	5
305	R:R:A358	R:R:L359	1.58	No	No	0	5	5
306	R:R:I84	R:R:V88	1.54	No	No	0	5	6
307	R:R:I286	R:R:V290	1.54	No	No	0	6	5
308	R:R:L264	R:R:V178	1.49	No	No	0	4	7
309	R:R:L235	R:R:V212	1.49	No	No	0	4	4
310	R:R:L305	R:R:V309	1.49	No	No	0	6	4
311	R:R:L221	R:R:T70	1.47	Yes	No	0	3	7
312	R:R:I126	R:R:L90	1.43	No	Yes	0	5	6
313	R:R:I314	R:R:Q233	1.37	Yes	No	0	2	1
314	R:R:D238	R:R:L235	1.36	No	No	0	2	4
315	R:R:A133	R:R:Y143	1.33	No	Yes	0	4	7
316	R:R:H137	R:R:I136	1.33	No	No	0	4	4
317	R:R:E276	R:R:N277	1.31	No	No	0	1	4
318	R:R:D353	R:R:H354	1.26	No	Yes	0	4	5
319	R:R:N179	R:R:W175	1.13	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y82	7.72667	6	1	7
2	R:R:F86	6.4325	4	1	6
3	R:R:L90	3.8175	4	1	6
4	R:R:F100	5.726	5	2	6
5	R:R:Y113	5.298	5	0	7
6	R:R:M114	5.914	5	2	8
7	R:R:D121	8.48833	6	2	9
8	R:R:F128	4.91	5	1	8
9	R:R:Y134	7.45333	6	1	5
10	R:R:H135	7.042	5	1	5
11	R:R:N139	7.6	5	1	5
12	R:R:W141	7.64167	6	1	9
13	R:R:Y143	7.175	4	0	7
14	R:R:Y156	8.2	4	0	5
15	R:R:N158	6.13833	6	2	8
16	R:R:Y160	7.465	4	4	7
17	R:R:F165	7.754	5	3	7
18	R:R:Q172	8.19	4	0	8
19	R:R:W199	11.6	4	3	9
20	R:R:L221	4.365	4	0	3
21	R:R:H227	6.55	4	5	5
22	R:R:D228	4.8375	4	1	4
23	R:R:F240	5.3475	4	0	3
24	R:R:Y242	8.99	4	0	5
25	R:R:F243	10.8275	4	0	6
26	R:R:P254	3.625	4	0	9
27	R:R:Y262	7.706	5	0	9
28	R:R:L288	5.12	4	0	8
29	R:R:M295	4.1875	4	0	6
30	R:R:Y296	6.25	4	7	9
31	R:R:H310	12.146	5	5	4
32	R:R:I314	4.416	5	5	2
33	R:R:V322	4.8225	4	0	4
34	R:R:Y323	7.095	6	0	4
35	R:R:Y326	12.4775	4	5	4
36	R:R:N336	6.2075	4	2	9
37	R:R:D340	7.47667	6	2	9
38	R:R:Y344	5.91778	9	2	9
39	R:R:Y345	5.8075	4	0	7
40	R:R:F346	5.225	4	0	7
41	R:R:V347	5.68	4	0	7
42	R:R:H354	6.9275	4	6	5
43	W:W:?1	11.8525	8	3	0
44	I:I:?1	8.206	5	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L69	R:R:Y323	28.8131	3.52	No	Yes	0	4	4
2	R:R:L69	R:R:N139	17.4176	6.87	No	Yes	1	4	5
3	R:R:N139	R:R:Y134	10.8836	10.47	Yes	Yes	1	5	5
4	R:R:W141	R:R:Y134	29.6557	8.68	Yes	Yes	1	9	5
5	R:R:W141	R:R:Y143	29.8623	15.43	Yes	Yes	0	9	7
6	R:R:I142	R:R:Y143	20.7052	7.25	No	Yes	0	1	7
7	R:R:I142	R:R:N140	19.1504	4.25	No	No	0	1	4
8	R:R:I223	R:R:N140	17.5893	8.5	No	No	0	3	4
9	R:R:I223	R:R:L221	16.0217	4.28	No	Yes	0	3	3
10	R:R:I218	R:R:L221	11.281	8.56	No	Yes	0	4	3
11	R:R:D228	R:R:L69	11.3764	4.07	Yes	No	1	4	4
12	R:R:H135	R:R:Y134	10.8868	10.89	Yes	Yes	1	5	5
13	R:R:I327	R:R:L78	17.1823	4.28	No	No	0	4	5
14	R:R:H135	R:R:P79	12.3748	4.58	Yes	No	0	5	5
15	R:R:I136	R:R:P79	10.0474	5.08	No	No	0	4	5
16	R:R:F128	R:R:Y82	10.1396	6.19	Yes	Yes	1	8	7
17	R:R:I132	R:R:I136	10.1078	2.94	No	No	0	7	4
18	R:R:D340	R:R:M295	94.1019	4.16	Yes	Yes	0	9	6
19	R:R:F300	R:R:M295	96.3435	4.98	No	Yes	0	9	6
20	R:R:F300	R:R:I163	95.2974	13.82	No	No	7	9	7
21	R:R:I163	R:R:P254	97.291	3.39	No	Yes	0	7	9
22	R:R:L164	R:R:P254	100	3.28	No	Yes	0	6	9
23	R:R:I198	R:R:L164	60.6117	4.28	No	No	0	7	6
24	R:R:F165	R:R:I198	60.5386	8.79	Yes	No	0	7	7
25	R:R:C161	R:R:F165	29.9959	4.19	No	Yes	0	7	7
26	R:R:C161	W:W:?1	29.1469	4.64	No	Yes	0	7	0
27	R:R:F154	W:W:?1	48.9301	13.36	No	Yes	3	5	0
28	R:R:F154	R:R:W127	49.3307	7.02	No	No	0	5	7
29	R:R:L151	R:R:W127	47.8045	7.97	No	No	0	5	7
30	R:R:L151	R:R:W141	47.2608	4.56	No	Yes	0	5	9
31	R:R:F165	R:R:W199	29.8178	6.01	Yes	Yes	3	7	9
32	R:R:W199	W:W:?1	29.0166	20	Yes	Yes	3	9	0
33	R:R:D340	R:R:Y344	78.077	5.75	Yes	Yes	2	9	9
34	R:R:A118	R:R:Y344	13.5194	4	No	Yes	0	8	9
35	R:R:A118	R:R:L97	12.4416	3.15	No	No	0	8	7
36	R:R:M114	R:R:Y344	61.6038	7.18	Yes	Yes	2	8	9
37	R:R:L169	R:R:M114	29.0325	4.24	No	Yes	0	8	8
38	R:R:L169	R:R:Y113	28.139	3.52	No	Yes	0	8	7
39	R:R:Q172	R:R:Y113	15.3699	3.38	Yes	Yes	0	8	7
40	R:R:M114	R:R:V347	38.781	6.09	Yes	Yes	0	8	7
41	R:R:C148	R:R:W141	11.3256	6.53	No	Yes	1	9	9
42	R:R:C148	R:R:T215	12.9503	3.38	No	No	1	9	4
43	R:R:H310	R:R:Y323	46.8761	7.62	Yes	Yes	0	4	4
44	R:R:H310	R:R:Y311	42.5837	6.53	Yes	No	0	4	5
45	R:R:F243	R:R:Y311	42.6695	9.28	Yes	No	0	6	5
46	R:R:F243	R:R:Y242	48.221	12.38	Yes	Yes	0	6	5
47	R:R:L246	R:R:Y242	53.0635	4.69	No	Yes	0	5	5
48	R:R:L164	R:R:V250	55.48	4.47	No	No	0	6	5
49	R:R:L288	R:R:V347	27.4141	4.47	Yes	Yes	0	8	7
50	R:R:L288	R:R:Y262	11.3923	9.38	Yes	Yes	0	8	9
51	R:R:K187	R:R:Q172	11.3287	8.14	No	Yes	0	6	8
52	R:R:R173	R:R:V347	10.5116	10.46	No	Yes	0	9	7
53	R:R:K187	R:R:M181	10.3335	4.32	No	No	0	6	5
54	R:R:H310	R:R:I314	16.0217	6.63	Yes	Yes	5	4	2
55	R:R:I314	R:R:V236	13.2365	7.68	Yes	No	0	2	3
56	R:R:K315	R:R:V236	12.1681	3.04	No	No	0	2	3
57	R:R:F240	R:R:K315	10.0124	6.2	Yes	No	0	3	2
58	R:R:F346	R:R:L288	15.4812	3.65	Yes	Yes	0	7	8
59	R:R:I327	R:R:Y323	17.4557	7.25	No	Yes	0	4	4
60	R:R:L78	R:R:Y82	12.5465	4.69	No	Yes	1	5	7
61	R:R:L246	R:R:V250	47.0796	4.47	No	No	4	5	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F165	R:R:N116	14.5	3	Yes	No	7	9	2	2
R:R:N116	R:R:W199	13.56	3	No	Yes	9	9	2	1
R:R:L119	R:R:L123	6.92	0	No	No	6	7	2	1
R:R:L119	R:R:W199	6.83	0	No	Yes	6	9	2	1
R:R:F154	R:R:L123	3.65	3	No	No	5	7	1	1
R:R:L123	W:W:?1	14.18	3	No	Yes	7	0	1	0
R:R:F154	R:R:W127	7.02	3	No	No	5	7	1	2
R:R:G153	R:R:Y210	5.79	0	No	No	6	5	2	1
R:R:F154	W:W:?1	13.36	3	No	Yes	5	0	1	0
R:R:A157	W:W:?1	10.37	0	No	Yes	5	0	1	0
R:R:C161	R:R:F165	4.19	0	No	Yes	7	7	1	2
R:R:C161	R:R:I202	4.91	0	No	No	7	8	1	2
R:R:C161	W:W:?1	4.64	0	No	Yes	7	0	1	0
R:R:F165	R:R:W199	6.01	3	Yes	Yes	7	9	2	1
R:R:W199	W:W:?1	20	3	Yes	Yes	9	0	1	0
R:R:L203	W:W:?1	10.13	0	No	Yes	3	0	1	0
R:R:T206	R:R:Y210	4.99	0	No	No	7	5	2	1
R:R:Y210	W:W:?1	18.87	0	No	Yes	5	0	1	0
R:R:V211	W:W:?1	3.27	0	No	Yes	3	0	1	0
R:R:L203	R:R:L204	2.77	0	No	No	3	4	1	2
R:R:V211	R:R:V212	1.6	0	No	No	3	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
36.36	Single	8U4R	Cholesterol	8U4R-CXCR4-REGN7663-Fab-Cholesterol
33.33	Single	7FEE	ZCZ011	7FEE-CB₁-PubMed 104895-ZCZ011
21.43	Single	7WV9	ZCZ011	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
21.43	Single	8G94	CD69	8G94-S1P₁-CD69-Gi1/&β;1/&γ;2
21.43	Consensus	cb1_on_allo	Other Ligand	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
16.67	Single	6KQI	ORG27569	6KQI-CB₁-PubMed 104895-ORG27569
16.67	Consensus	cb1_off_allo	Other Ligand	6KQI-CB₁-PubMed 104895-ORG27569
15.38	Single	8U4O	Cholesterol	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
14.29	Single	8U4Q	Cholesterol	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
9.09	Single	8SAI	1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine	8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
8.33	Single	8U4N	Cholesterol	8U4N-CXCR4-Cholesterol-Gi1/&β;1/&γ;2
7.69	Single	8T3O	2Y5	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8U4P	Cholesterol	8U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
7.69	Consensus	ffa4_on_allo	Other Ligand	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67	Consensus	mt1_on	Orthosteric Ligand	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
5.88	Single	8IYX	YL-365	8IYX-GPR34-YL-365
5.88	Single	8T3V	DHA	8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Consensus	gi_melatonin	Orthosteric Ligand	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
5.56	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
5.56	Consensus	ffa1_on	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
4.17	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
3.57	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
3.45	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2

PDB Summary
PDB	5NDZ
Class	A
SubFamily	Peptide
Type	Proteinase-activated
SubType	PAR2
Species	Homo sapiens
Ligand	-
Other Ligand(s)	AZ3451; Na
Protein Partners	-
PDB Resolution	3.6
Date	2017-05-03
D.O.I.	10.1038/nature22309

Net Summary
I_min	3.28
Number of Linked Nodes	276
Number of Links	319
Number of Hubs	44
Number of Links mediated by Hubs	170
Number of Communities	7
Number of Nodes involved in Communities	60
Number of Links involved in Communities	86

Path Summary
Number Of Nodes in MetaPath	62
Number Of Links MetaPath	61
Number of Shortest Paths	57730
Length Of Smallest Path	3
Average Path Length	15.7981
Length of Longest Path	35
Minimum Path Strength	1.38
Average Path Strength	6.44554
Maximum Path Strength	19.975
Minimum Path Correlation	0.7
Average Path Correlation	0.925881
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	44.8655
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.2837
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	8UN
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	8UN
Name	2-(6-bromanyl-1,3-benzodioxol-5-yl)-~{N}-(4-cyanophenyl)-1-[(1~{S})-1-cyclohexylethyl]benzimidazole-5-carboxamide
Synonyms
Identifier	2-(6-bromanyl-1,3-benzodioxol-5-yl)-~{N}-(4-cyanophenyl)-1-[(1~{S})-1-cyclohexylethyl]benzimidazole-5-carboxamide
Formula	C30 H27 Br N4 O3
Molecular Weight	571.464
SMILES	C[C@@H](C1CCCCC1)n2c3ccc(cc3nc2c4cc5c(cc4Br)OCO5)C(=O)Nc6ccc(cc6)C#N
PubChem	126961335
Formal Charge	0
Total Atoms	65
Total Chiral Atoms	1
Total Bonds	70
Total Aromatic Bonds	22


Code	NA
PDB Residues	I:I:?1
Environment Details	Open EMBL-EBI Page
Code	NA
Name	SODIUM ION
Synonyms
Identifier	sodium(+1) cation
Formula	Na
Molecular Weight	22.99
SMILES	[Na+]
PubChem
Formal Charge	1
Total Atoms	1
Total Chiral Atoms	0
Total Bonds	0
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P55085
Sequence	>5NDZ_Chain_R F S V D E F S A S V L T G K L T T V F L P I V Y T I V F V V A L P S N G M A L W V F L F R T K K K A P A V I Y M A N L A L A D L L S V I W F P L K I A Y H I H G N N W I Y G E A L C N V L I G F F Y A N M Y C S I L F L T C L S V Q R A W E I V N P M G H S R K K A N I A I G I S L A I W L L I L L V T I P L Y V V K Q T I F I P A L Q I T T C H D V L P E Q L L V G D M F N Y F L S L A I G V F L F P A F L T A S A Y V L M I R A L E N S E K K R K R A I K L A V T V A A M Y L I C F T P S N L L L V V H Y F L I K S Q G Q S H V Y A L Y I V A L C L S T L N S C I D P F V Y Y F V S H D F R D H A K N A L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5NDD	A	Peptide	Proteinase-activated	PAR2	Homo sapiens	-	AZ8838; Na	-	2.8	2017-05-03	10.1038/nature22309
	5NDZ	A	Peptide	Proteinase-activated	PAR2	Homo sapiens	-	AZ3451; Na	-	3.6	2017-05-03	10.1038/nature22309
	5NJ6	A	Peptide	Proteinase-activated	PAR2	Homo sapiens	-	-	-	4	2017-05-03	10.1038/nature22309

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