psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F59	R:R:P219	4.33	No	No	0	7	1
2	R:R:A220	R:R:F59	5.55	No	No	0	1	7
3	R:R:A220	R:R:S60	3.42	No	No	0	1	7
4	R:R:D62	R:R:S65	8.83	No	No	0	7	5
5	R:R:D62	R:R:Q319	5.22	No	No	0	7	4
6	R:R:F64	R:R:Y323	5.16	No	Yes	0	2	4
7	R:R:S65	R:R:Y323	11.45	No	Yes	0	5	4
8	R:R:V68	R:R:Y323	7.57	No	Yes	0	4	4
9	R:R:L69	R:R:N139	6.87	No	Yes	1	4	5
10	R:R:D228	R:R:L69	4.07	Yes	No	1	4	4
11	R:R:L69	R:R:Y323	3.52	No	Yes	0	4	4
12	R:R:K72	R:R:V76	4.55	No	No	0	2	4
13	R:R:F77	R:R:L73	4.87	No	No	0	4	3
14	R:R:N139	R:R:T74	10.24	Yes	No	0	5	4
15	R:R:F77	R:R:V81	5.24	No	No	0	4	6
16	R:R:L78	R:R:Y82	4.69	No	Yes	1	5	7
17	R:R:H135	R:R:L78	9	Yes	No	1	5	5
18	R:R:I327	R:R:L78	4.28	No	No	0	4	5
19	R:R:H135	R:R:P79	4.58	Yes	No	0	5	5
20	R:R:I136	R:R:P79	5.08	No	No	0	4	5
21	R:R:C331	R:R:V81	3.42	No	No	0	6	6
22	R:R:F128	R:R:Y82	6.19	Yes	Yes	1	8	7
23	R:R:K131	R:R:Y82	16.72	No	Yes	1	7	7
24	R:R:H135	R:R:Y82	4.36	Yes	Yes	1	5	7
25	R:R:C331	R:R:Y82	9.41	No	Yes	0	6	7
26	R:R:T334	R:R:Y82	4.99	No	Yes	1	7	7
27	R:R:I132	R:R:T83	7.6	No	No	0	7	5
28	R:R:C338	R:R:V85	5.12	No	No	0	7	8
29	R:R:F86	R:R:L90	6.09	Yes	Yes	1	6	6
30	R:R:F86	R:R:V125	5.24	Yes	No	1	6	6
31	R:R:F128	R:R:F86	4.29	Yes	Yes	1	8	6
32	R:R:F86	R:R:P129	10.11	Yes	No	0	6	8
33	R:R:C338	R:R:V88	5.12	No	No	0	7	6
34	R:R:A89	R:R:S337	3.42	No	No	0	8	9
35	R:R:L90	R:R:P91	3.28	Yes	No	0	6	5
36	R:R:L90	R:R:V125	4.47	Yes	No	1	6	6
37	R:R:P341	R:R:S92	7.13	No	No	0	9	7
38	R:R:D121	R:R:N93	14.81	Yes	No	2	9	9
39	R:R:N93	R:R:P341	8.15	No	No	0	9	9
40	R:R:N93	R:R:Y344	6.98	No	Yes	2	9	9
41	R:R:G94	R:R:L122	3.42	No	No	0	4	8
42	R:R:F351	R:R:M95	3.73	No	No	0	8	6
43	R:R:A96	R:R:Y344	4	No	Yes	2	9	9
44	R:R:A96	R:R:F351	4.16	No	No	2	9	8
45	R:R:L101	R:R:L97	5.54	No	No	0	4	7
46	R:R:F102	R:R:W98	6.01	No	No	0	4	3
47	R:R:R103	R:R:W98	16.99	No	No	6	5	3
48	R:R:H354	R:R:W98	6.35	Yes	No	6	5	3
49	R:R:R103	R:R:V99	3.92	No	No	6	5	8
50	R:R:H354	R:R:V99	11.07	Yes	No	6	5	8
51	R:R:F100	R:R:V111	5.24	Yes	No	0	6	7
52	R:R:F100	R:R:M114	7.46	Yes	Yes	2	6	8
53	R:R:A115	R:R:F100	4.16	No	Yes	0	7	6
54	R:R:F100	R:R:Y344	5.16	Yes	Yes	2	6	9
55	R:R:F100	R:R:S348	6.61	Yes	No	2	6	8
56	R:R:F102	R:R:L101	7.31	No	No	0	4	4
57	R:R:H354	R:R:R103	9.03	Yes	No	6	5	5
58	R:R:T104	R:R:V111	7.93	No	No	0	6	7
59	R:R:D350	R:R:T104	8.67	No	No	0	6	6
60	R:R:H349	R:R:K106	6.55	No	No	0	5	7
61	R:R:D350	R:R:K106	8.3	No	No	0	6	7
62	R:R:P109	R:R:Q172	11.05	No	Yes	0	7	8
63	R:R:A191	R:R:P109	3.74	No	No	0	8	7
64	R:R:A191	R:R:I112	4.87	No	No	0	8	6
65	R:R:I112	R:R:I192	4.42	No	No	0	6	3
66	R:R:C168	R:R:Y113	10.75	No	Yes	0	7	7
67	R:R:L169	R:R:Y113	3.52	No	Yes	0	8	7
68	R:R:Q172	R:R:Y113	3.38	Yes	Yes	0	8	7
69	R:R:A191	R:R:Y113	4	No	Yes	0	8	7
70	R:R:I194	R:R:Y113	4.84	No	Yes	0	5	7
71	R:R:L169	R:R:M114	4.24	No	Yes	0	8	8
72	R:R:M114	R:R:Y344	7.18	Yes	Yes	2	8	9
73	R:R:M114	R:R:V347	6.09	Yes	Yes	0	8	7
74	R:R:M114	R:R:S348	4.6	Yes	No	2	8	8
75	R:R:F165	R:R:N116	14.5	Yes	No	3	7	9
76	R:R:N116	R:R:S195	8.94	No	No	3	9	7
77	R:R:N116	R:R:W199	13.56	No	Yes	3	9	9
78	R:R:D340	R:R:L117	12.21	Yes	No	2	9	9
79	R:R:L117	R:R:Y344	10.55	No	Yes	2	9	9
80	R:R:A118	R:R:Y344	4	No	Yes	0	8	9
81	R:R:L119	R:R:L123	6.92	No	No	0	6	7
82	R:R:L119	R:R:W199	6.83	No	Yes	0	6	9
83	R:R:A120	R:R:N158	4.69	No	Yes	0	8	8
84	R:R:D121	R:R:N158	5.39	Yes	Yes	2	9	8
85	R:R:D121	R:R:S337	5.89	Yes	No	0	9	9
86	R:R:D121	R:R:D340	10.65	Yes	Yes	2	9	9
87	R:R:D121	R:R:Y344	3.45	Yes	Yes	2	9	9
88	I:I:?1	R:R:D121	10.73	Yes	Yes	2	0	9
89	R:R:F154	R:R:L123	3.65	No	No	3	5	7
90	R:R:L123	W:W:?1	14.18	No	Yes	3	7	0
91	R:R:N158	R:R:S124	4.47	Yes	No	0	8	7
92	R:R:V150	R:R:W127	3.68	No	No	0	5	7
93	R:R:L151	R:R:W127	7.97	No	No	0	5	7
94	R:R:F154	R:R:W127	7.02	No	No	0	5	7
95	R:R:F128	R:R:K131	4.96	Yes	No	1	8	7
96	R:R:F128	R:R:T334	6.49	Yes	No	1	8	7
97	R:R:L130	R:R:Y143	4.69	No	Yes	0	7	7
98	R:R:H135	R:R:Y134	10.89	Yes	Yes	1	5	5
99	R:R:N139	R:R:Y134	10.47	Yes	Yes	1	5	5
100	R:R:W141	R:R:Y134	8.68	Yes	Yes	1	9	5
101	R:R:T225	R:R:Y134	3.75	No	Yes	1	4	5
102	R:R:C226	R:R:Y134	4.03	No	Yes	1	9	5
103	R:R:D228	R:R:Y134	6.9	Yes	Yes	1	4	5
104	R:R:H135	R:R:N139	6.38	Yes	Yes	1	5	5
105	R:R:D228	R:R:N139	4.04	Yes	Yes	1	4	5
106	R:R:I142	R:R:N140	4.25	No	No	0	1	4
107	R:R:I223	R:R:N140	8.5	No	No	0	3	4
108	R:R:W141	R:R:Y143	15.43	Yes	Yes	0	9	7
109	R:R:C148	R:R:W141	6.53	No	Yes	1	9	9
110	R:R:L151	R:R:W141	4.56	No	Yes	0	5	9
111	R:R:C226	R:R:W141	7.84	No	Yes	1	9	9
112	R:R:I142	R:R:Y143	7.25	No	Yes	0	1	7
113	R:R:E145	R:R:K213	10.8	No	No	1	3	5
114	R:R:E145	R:R:T215	9.88	No	No	1	3	4
115	R:R:L147	R:R:V150	4.47	No	No	0	6	5
116	R:R:C148	R:R:T215	3.38	No	No	1	9	4
117	R:R:C148	R:R:C226	7.28	No	No	1	9	9
118	R:R:N149	R:R:Q214	6.6	No	No	0	6	4
119	R:R:I152	R:R:Q214	6.86	No	No	0	5	4
120	R:R:H227	R:R:I152	9.28	Yes	No	0	5	5
121	R:R:G153	R:R:Y210	5.79	No	No	0	6	5
122	R:R:F154	W:W:?1	13.36	No	Yes	3	5	0
123	R:R:F155	R:R:Y156	13.41	No	Yes	0	6	5
124	R:R:F155	R:R:L330	4.87	No	No	0	6	5
125	R:R:L209	R:R:Y156	3.52	No	Yes	0	4	5
126	R:R:H227	R:R:Y156	7.62	Yes	Yes	0	5	5
127	R:R:F243	R:R:Y156	8.25	Yes	Yes	0	6	5
128	R:R:A157	W:W:?1	10.37	No	Yes	0	5	0
129	R:R:N158	R:R:S162	5.96	Yes	No	2	8	9
130	R:R:N158	R:R:N336	8.17	Yes	Yes	2	8	9
131	I:I:?1	R:R:N158	8.15	Yes	Yes	2	0	8
132	R:R:M159	R:R:Y160	7.18	No	Yes	4	7	7
133	R:R:L246	R:R:Y160	11.72	No	Yes	4	5	7
134	R:R:V250	R:R:Y160	6.31	No	Yes	4	5	7
135	R:R:N304	R:R:Y160	4.65	No	Yes	0	8	7
136	R:R:C161	R:R:F165	4.19	No	Yes	0	7	7
137	R:R:C161	R:R:I202	4.91	No	No	0	7	8
138	R:R:C161	W:W:?1	4.64	No	Yes	0	7	0
139	R:R:N336	R:R:S162	4.47	Yes	No	2	9	9
140	I:I:?1	R:R:S162	5.94	Yes	No	2	0	9
141	R:R:I163	R:R:P254	3.39	No	Yes	0	7	9
142	R:R:I163	R:R:Y296	3.63	No	Yes	7	7	9
143	R:R:F300	R:R:I163	13.82	No	No	7	9	7
144	R:R:I198	R:R:L164	4.28	No	No	0	7	6
145	R:R:L164	R:R:V250	4.47	No	No	0	6	5
146	R:R:L164	R:R:P254	3.28	No	Yes	0	6	9
147	R:R:F165	R:R:S195	5.28	Yes	No	3	7	7
148	R:R:F165	R:R:I198	8.79	Yes	No	0	7	7
149	R:R:F165	R:R:W199	6.01	Yes	Yes	3	7	9
150	R:R:L166	R:R:V292	4.47	No	No	0	8	8
151	R:R:P254	R:R:T167	3.5	Yes	No	0	9	7
152	R:R:T167	R:R:T258	6.28	No	No	0	7	8
153	R:R:S170	R:R:Y262	11.45	No	Yes	0	9	9
154	R:R:E176	R:R:Q172	10.19	No	Yes	0	8	8
155	R:R:K187	R:R:Q172	8.14	No	Yes	0	6	8
156	R:R:K281	R:R:R173	3.71	No	No	0	5	9
157	R:R:R173	R:R:V347	10.46	No	Yes	0	9	7
158	R:R:A174	R:R:M265	4.83	No	No	0	8	8
159	R:R:I177	R:R:L269	5.71	No	No	0	8	8
160	R:R:N179	R:R:V178	4.43	No	No	0	6	7
161	R:R:K187	R:R:M181	4.32	No	No	0	6	5
162	R:R:H183	R:R:K186	7.86	No	No	0	6	7
163	R:R:W199	W:W:?1	20	Yes	Yes	3	9	0
164	R:R:L203	W:W:?1	10.13	No	Yes	0	3	0
165	R:R:T206	R:R:Y210	4.99	No	No	0	7	5
166	R:R:I207	R:R:P208	3.39	No	No	0	4	7
167	R:R:P208	R:R:Y242	8.34	No	Yes	0	7	5
168	R:R:L209	R:R:Y242	10.55	No	Yes	0	4	5
169	R:R:Y210	W:W:?1	18.87	No	Yes	0	5	0
170	R:R:K213	R:R:T215	6.01	No	No	1	5	4
171	R:R:K213	R:R:P231	3.35	No	No	0	5	4
172	R:R:I216	R:R:P231	8.47	No	No	0	1	4
173	R:R:F217	R:R:P219	5.78	No	No	0	1	1
174	R:R:F217	R:R:T224	5.19	No	No	0	1	5
175	R:R:I218	R:R:P219	3.39	No	No	0	4	1
176	R:R:I218	R:R:L221	8.56	No	Yes	0	4	3
177	R:R:I223	R:R:L221	4.28	No	Yes	0	3	3
178	R:R:D228	R:R:T225	4.34	Yes	No	1	4	4
179	R:R:T225	R:R:V229	9.52	No	No	0	4	4
180	R:R:H227	R:R:Y326	5.44	Yes	Yes	5	5	4
181	R:R:H227	R:R:L330	3.86	Yes	No	5	5	5
182	R:R:L230	R:R:P231	4.93	No	No	0	5	4
183	R:R:E232	R:R:L234	9.28	No	No	0	1	5
184	R:R:E232	R:R:L235	5.3	No	No	0	1	4
185	R:R:I314	R:R:V236	7.68	Yes	No	0	2	3
186	R:R:G237	R:R:K315	6.97	No	No	0	1	2
187	R:R:M239	R:R:Y311	7.18	No	No	0	4	5
188	R:R:F240	R:R:N241	4.83	Yes	No	0	3	3
189	R:R:F240	R:R:V308	3.93	Yes	No	0	3	6
190	R:R:F240	R:R:F312	6.43	Yes	No	0	3	3
191	R:R:F240	R:R:K315	6.2	Yes	No	0	3	2
192	R:R:F243	R:R:Y242	12.38	Yes	Yes	0	6	5
193	R:R:L246	R:R:Y242	4.69	No	Yes	0	5	5
194	R:R:F243	R:R:L307	13.4	Yes	No	0	6	5
195	R:R:F243	R:R:Y311	9.28	Yes	No	0	6	5
196	R:R:L246	R:R:V250	4.47	No	No	4	5	5
197	R:R:G249	R:R:I248	3.53	No	No	0	5	4
198	R:R:F251	R:R:L252	4.87	No	No	0	8	4
199	R:R:F251	R:R:T301	6.49	No	No	0	8	5
200	R:R:F251	R:R:N304	16.92	No	No	0	8	8
201	R:R:F253	R:R:P254	4.33	No	Yes	0	6	9
202	R:R:F253	R:R:L257	7.31	No	No	0	6	7
203	R:R:A255	R:R:Y296	4	No	Yes	0	7	9
204	R:R:T258	R:R:Y296	4.99	No	Yes	0	8	9
205	R:R:M265	R:R:Y262	4.79	No	Yes	0	8	9
206	R:R:L288	R:R:Y262	9.38	Yes	Yes	0	8	9
207	R:R:A289	R:R:Y262	5.34	No	Yes	0	8	9
208	R:R:V292	R:R:Y262	7.57	No	Yes	0	8	9
209	R:R:R267	R:R:V263	6.54	No	No	0	4	3
210	R:R:K280	R:R:N277	8.39	No	No	0	4	4
211	R:R:E279	R:R:R282	4.65	No	No	0	3	6
212	R:R:E279	R:R:K283	6.75	No	No	0	3	5
213	R:R:K280	R:R:R284	8.66	No	No	0	4	7
214	R:R:K281	R:R:R284	3.71	No	No	0	5	7
215	R:R:I286	R:R:R282	6.26	No	No	0	6	6
216	R:R:R284	R:R:R352	10.66	No	No	0	7	8
217	R:R:F346	R:R:K287	7.44	Yes	No	0	7	5
218	R:R:F346	R:R:L288	3.65	Yes	Yes	0	7	8
219	R:R:L288	R:R:V347	4.47	Yes	Yes	0	8	7
220	R:R:F300	R:R:M295	4.98	No	Yes	0	9	6
221	R:R:I339	R:R:M295	4.37	No	Yes	0	6	6
222	R:R:D340	R:R:M295	4.16	Yes	Yes	0	9	6
223	R:R:F300	R:R:Y296	12.38	No	Yes	7	9	9
224	R:R:P302	R:R:T301	3.5	No	No	0	9	5
225	R:R:S303	R:R:S333	4.89	No	No	4	7	8
226	R:R:L306	R:R:V322	4.47	No	Yes	0	4	4
227	R:R:L307	R:R:Y326	5.86	No	Yes	0	5	4
228	R:R:V309	R:R:V322	4.81	No	Yes	0	4	4
229	R:R:H310	R:R:Y311	6.53	Yes	No	0	4	5
230	R:R:H310	R:R:I314	6.63	Yes	Yes	5	4	2
231	R:R:H310	R:R:S320	8.37	Yes	No	5	4	2
232	R:R:H310	R:R:Y323	7.62	Yes	Yes	0	4	4
233	R:R:H310	R:R:Y326	31.58	Yes	Yes	5	4	4
234	R:R:F312	R:R:S316	3.96	No	No	0	3	1
235	R:R:L313	R:R:S320	4.5	No	No	0	1	2
236	R:R:H321	R:R:L313	3.86	No	No	0	4	1
237	R:R:I314	R:R:S320	4.64	Yes	No	5	2	2
238	R:R:Q317	R:R:S316	4.33	No	No	0	1	1
239	R:R:H321	R:R:V322	5.54	No	Yes	0	4	4
240	R:R:L325	R:R:V322	4.47	No	Yes	0	5	4
241	R:R:I327	R:R:Y323	7.25	No	Yes	0	4	4
242	R:R:L330	R:R:Y326	7.03	No	Yes	5	5	4
243	R:R:D340	R:R:N336	4.04	Yes	Yes	2	9	9
244	I:I:?1	R:R:N336	8.15	Yes	Yes	2	0	9
245	R:R:D340	R:R:Y344	5.75	Yes	Yes	2	9	9
246	I:I:?1	R:R:D340	8.05	Yes	Yes	2	0	9
247	R:R:F351	R:R:Y344	6.19	No	Yes	2	8	9
248	R:R:F346	R:R:Y345	7.22	Yes	Yes	0	7	7
249	R:R:R352	R:R:Y345	6.17	No	Yes	0	8	7
250	R:R:K356	R:R:Y345	7.17	No	Yes	0	4	7
251	R:R:H349	R:R:R352	6.77	No	No	0	5	8
252	R:R:V211	W:W:?1	3.27	No	Yes	0	3	0
253	R:R:C299	R:R:I298	3.27	No	No	0	9	6
254	R:R:C299	R:R:M295	3.24	No	Yes	0	9	6
255	R:R:S65	R:R:V61	3.23	No	No	0	5	6
256	R:R:A66	R:R:L221	3.15	No	Yes	0	4	3
257	R:R:A118	R:R:L97	3.15	No	No	0	8	7
258	R:R:T74	R:R:T75	3.14	No	No	0	4	5
259	R:R:A247	R:R:N304	3.13	No	No	0	5	8
260	R:R:M159	R:R:S303	3.07	No	No	4	7	7
261	R:R:M159	R:R:S333	3.07	No	No	4	7	8
262	R:R:I202	R:R:V205	3.07	No	No	0	8	5
263	R:R:K315	R:R:V236	3.04	No	No	0	2	3
264	R:R:K72	R:R:T75	3	No	No	0	2	5
265	R:R:L73	R:R:V328	2.98	No	No	0	3	6
266	R:R:L244	R:R:V308	2.98	No	No	0	5	6
267	R:R:L288	R:R:V343	2.98	Yes	No	0	8	8
268	R:R:L332	R:R:V328	2.98	No	No	0	8	6
269	R:R:I132	R:R:I136	2.94	No	No	0	7	4
270	R:R:I190	R:R:I194	2.94	No	No	0	4	5
271	R:R:I266	R:R:I286	2.94	No	No	0	5	6
272	R:R:A133	R:R:H137	2.93	No	No	0	4	4
273	R:R:K283	R:R:K287	2.87	No	No	0	5	5
274	R:R:I248	R:R:L244	2.85	No	No	0	4	5
275	R:R:K281	R:R:L269	2.82	No	No	0	5	8
276	R:R:G144	R:R:W141	2.81	No	Yes	0	8	9
277	R:R:A324	R:R:F64	2.77	No	No	0	1	2
278	R:R:L122	R:R:L97	2.77	No	No	0	8	7
279	R:R:L203	R:R:L204	2.77	No	No	0	3	4
280	R:R:A355	R:R:Y345	2.67	No	Yes	0	7	7
281	R:R:F128	R:R:V85	2.62	Yes	No	0	8	8
282	R:R:F342	R:R:T291	2.59	No	No	0	6	5
283	R:R:F346	R:R:T291	2.59	Yes	No	0	7	5
284	R:R:F256	R:R:L257	2.44	No	No	0	3	7
285	R:R:M181	R:R:W175	2.33	No	No	0	5	5
286	R:R:A108	R:R:P109	1.87	No	No	0	7	7
287	R:R:A329	R:R:P302	1.87	No	No	0	7	9
288	R:R:G138	R:R:T75	1.82	No	No	0	4	5
289	R:R:A174	R:R:A261	1.79	No	No	0	8	7
290	R:R:G193	R:R:I192	1.76	No	No	0	2	3
291	R:R:G318	R:R:I314	1.76	No	Yes	0	1	2
292	R:R:G182	R:R:M181	1.75	No	No	0	4	5
293	R:R:G193	R:R:L196	1.71	No	No	0	2	5
294	R:R:A110	R:R:V347	1.7	No	Yes	0	8	7
295	R:R:A261	R:R:V171	1.7	No	No	0	7	6
296	R:R:N179	R:R:P180	1.63	No	No	0	6	8
297	R:R:S67	R:R:V68	1.62	No	No	0	4	4
298	R:R:A188	R:R:I112	1.62	No	No	0	3	6
299	R:R:A268	R:R:I177	1.62	No	No	0	5	8
300	R:R:A285	R:R:M265	1.61	No	No	0	7	8
301	R:R:V211	R:R:V212	1.6	No	No	0	3	4
302	R:R:T83	R:R:V87	1.59	No	No	0	5	5
303	R:R:G182	R:R:H183	1.59	No	No	0	4	6
304	R:R:C299	R:R:L335	1.59	No	No	0	9	5
305	R:R:A358	R:R:L359	1.58	No	No	0	5	5
306	R:R:I84	R:R:V88	1.54	No	No	0	5	6
307	R:R:I286	R:R:V290	1.54	No	No	0	6	5
308	R:R:L264	R:R:V178	1.49	No	No	0	4	7
309	R:R:L235	R:R:V212	1.49	No	No	0	4	4
310	R:R:L305	R:R:V309	1.49	No	No	0	6	4
311	R:R:L221	R:R:T70	1.47	Yes	No	0	3	7
312	R:R:I126	R:R:L90	1.43	No	Yes	0	5	6
313	R:R:I314	R:R:Q233	1.37	Yes	No	0	2	1
314	R:R:D238	R:R:L235	1.36	No	No	0	2	4
315	R:R:A133	R:R:Y143	1.33	No	Yes	0	4	7
316	R:R:H137	R:R:I136	1.33	No	No	0	4	4
317	R:R:E276	R:R:N277	1.31	No	No	0	1	4
318	R:R:D353	R:R:H354	1.26	No	Yes	0	4	5
319	R:R:N179	R:R:W175	1.13	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y82	7.72667	6	1	7
2	R:R:F86	6.4325	4	1	6
3	R:R:L90	3.8175	4	1	6
4	R:R:F100	5.726	5	2	6
5	R:R:Y113	5.298	5	0	7
6	R:R:M114	5.914	5	2	8
7	R:R:D121	8.48667	6	2	9
8	R:R:F128	4.91	5	1	8
9	R:R:Y134	7.45333	6	1	5
10	R:R:H135	7.042	5	1	5
11	R:R:N139	7.6	5	1	5
12	R:R:W141	7.64167	6	1	9
13	R:R:Y143	7.175	4	0	7
14	R:R:Y156	8.2	4	0	5
15	R:R:N158	6.13833	6	2	8
16	R:R:Y160	7.465	4	4	7
17	R:R:F165	7.754	5	3	7
18	R:R:Q172	8.19	4	0	8
19	R:R:W199	11.6	4	3	9
20	R:R:L221	4.365	4	0	3
21	R:R:H227	6.55	4	5	5
22	R:R:D228	4.8375	4	1	4
23	R:R:F240	5.3475	4	0	3
24	R:R:Y242	8.99	4	0	5
25	R:R:F243	10.8275	4	0	6
26	R:R:P254	3.625	4	0	9
27	R:R:Y262	7.706	5	0	9
28	R:R:L288	5.12	4	0	8
29	R:R:M295	4.1875	4	0	6
30	R:R:Y296	6.25	4	7	9
31	R:R:H310	12.146	5	5	4
32	R:R:I314	4.416	5	5	2
33	R:R:V322	4.8225	4	0	4
34	R:R:Y323	7.095	6	0	4
35	R:R:Y326	12.4775	4	5	4
36	R:R:N336	6.2075	4	2	9
37	R:R:D340	7.47667	6	2	9
38	R:R:Y344	5.91778	9	2	9
39	R:R:Y345	5.8075	4	0	7
40	R:R:F346	5.225	4	0	7
41	R:R:V347	5.68	4	0	7
42	R:R:H354	6.9275	4	6	5
43	W:W:?1	11.8525	8	3	0
44	I:I:?1	8.204	5	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L69	R:R:Y323	28.8131	3.52	No	Yes	0	4	4
2	R:R:L69	R:R:N139	17.4176	6.87	No	Yes	1	4	5
3	R:R:N139	R:R:Y134	10.8836	10.47	Yes	Yes	1	5	5
4	R:R:W141	R:R:Y134	29.6557	8.68	Yes	Yes	1	9	5
5	R:R:W141	R:R:Y143	29.8623	15.43	Yes	Yes	0	9	7
6	R:R:I142	R:R:Y143	20.7052	7.25	No	Yes	0	1	7
7	R:R:I142	R:R:N140	19.1504	4.25	No	No	0	1	4
8	R:R:I223	R:R:N140	17.5893	8.5	No	No	0	3	4
9	R:R:I223	R:R:L221	16.0217	4.28	No	Yes	0	3	3
10	R:R:I218	R:R:L221	11.281	8.56	No	Yes	0	4	3
11	R:R:D228	R:R:L69	11.3764	4.07	Yes	No	1	4	4
12	R:R:H135	R:R:Y134	10.8868	10.89	Yes	Yes	1	5	5
13	R:R:I327	R:R:L78	17.1823	4.28	No	No	0	4	5
14	R:R:H135	R:R:P79	12.3748	4.58	Yes	No	0	5	5
15	R:R:I136	R:R:P79	10.0474	5.08	No	No	0	4	5
16	R:R:F128	R:R:Y82	10.1396	6.19	Yes	Yes	1	8	7
17	R:R:I132	R:R:I136	10.1078	2.94	No	No	0	7	4
18	R:R:D340	R:R:M295	94.1019	4.16	Yes	Yes	0	9	6
19	R:R:F300	R:R:M295	96.3435	4.98	No	Yes	0	9	6
20	R:R:F300	R:R:I163	95.2974	13.82	No	No	7	9	7
21	R:R:I163	R:R:P254	97.291	3.39	No	Yes	0	7	9
22	R:R:L164	R:R:P254	100	3.28	No	Yes	0	6	9
23	R:R:I198	R:R:L164	60.6117	4.28	No	No	0	7	6
24	R:R:F165	R:R:I198	60.5386	8.79	Yes	No	0	7	7
25	R:R:C161	R:R:F165	29.9959	4.19	No	Yes	0	7	7
26	R:R:C161	W:W:?1	29.1469	4.64	No	Yes	0	7	0
27	R:R:F154	W:W:?1	48.9301	13.36	No	Yes	3	5	0
28	R:R:F154	R:R:W127	49.3307	7.02	No	No	0	5	7
29	R:R:L151	R:R:W127	47.8045	7.97	No	No	0	5	7
30	R:R:L151	R:R:W141	47.2608	4.56	No	Yes	0	5	9
31	R:R:F165	R:R:W199	29.8178	6.01	Yes	Yes	3	7	9
32	R:R:W199	W:W:?1	29.0166	20	Yes	Yes	3	9	0
33	R:R:D340	R:R:Y344	78.077	5.75	Yes	Yes	2	9	9
34	R:R:A118	R:R:Y344	13.5194	4	No	Yes	0	8	9
35	R:R:A118	R:R:L97	12.4416	3.15	No	No	0	8	7
36	R:R:M114	R:R:Y344	61.6038	7.18	Yes	Yes	2	8	9
37	R:R:L169	R:R:M114	29.0325	4.24	No	Yes	0	8	8
38	R:R:L169	R:R:Y113	28.139	3.52	No	Yes	0	8	7
39	R:R:Q172	R:R:Y113	15.3699	3.38	Yes	Yes	0	8	7
40	R:R:M114	R:R:V347	38.781	6.09	Yes	Yes	0	8	7
41	R:R:C148	R:R:W141	11.3256	6.53	No	Yes	1	9	9
42	R:R:C148	R:R:T215	12.9503	3.38	No	No	1	9	4
43	R:R:H310	R:R:Y323	46.8761	7.62	Yes	Yes	0	4	4
44	R:R:H310	R:R:Y311	42.5837	6.53	Yes	No	0	4	5
45	R:R:F243	R:R:Y311	42.6695	9.28	Yes	No	0	6	5
46	R:R:F243	R:R:Y242	48.221	12.38	Yes	Yes	0	6	5
47	R:R:L246	R:R:Y242	53.0635	4.69	No	Yes	0	5	5
48	R:R:L164	R:R:V250	55.48	4.47	No	No	0	6	5
49	R:R:L288	R:R:V347	27.4141	4.47	Yes	Yes	0	8	7
50	R:R:L288	R:R:Y262	11.3923	9.38	Yes	Yes	0	8	9
51	R:R:K187	R:R:Q172	11.3287	8.14	No	Yes	0	6	8
52	R:R:R173	R:R:V347	10.5116	10.46	No	Yes	0	9	7
53	R:R:K187	R:R:M181	10.3335	4.32	No	No	0	6	5
54	R:R:H310	R:R:I314	16.0217	6.63	Yes	Yes	5	4	2
55	R:R:I314	R:R:V236	13.2365	7.68	Yes	No	0	2	3
56	R:R:K315	R:R:V236	12.1681	3.04	No	No	0	2	3
57	R:R:F240	R:R:K315	10.0124	6.2	Yes	No	0	3	2
58	R:R:F346	R:R:L288	15.4812	3.65	Yes	Yes	0	7	8
59	R:R:I327	R:R:Y323	17.4557	7.25	No	Yes	0	4	4
60	R:R:L78	R:R:Y82	12.5465	4.69	No	Yes	1	5	7
61	R:R:L246	R:R:V250	47.0796	4.47	No	No	4	5	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F165	R:R:N116	14.5	3	Yes	No	7	9	2	2
R:R:N116	R:R:W199	13.56	3	No	Yes	9	9	2	1
R:R:L119	R:R:L123	6.92	0	No	No	6	7	2	1
R:R:L119	R:R:W199	6.83	0	No	Yes	6	9	2	1
R:R:F154	R:R:L123	3.65	3	No	No	5	7	1	1
R:R:L123	W:W:?1	14.18	3	No	Yes	7	0	1	0
R:R:F154	R:R:W127	7.02	3	No	No	5	7	1	2
R:R:G153	R:R:Y210	5.79	0	No	No	6	5	2	1
R:R:F154	W:W:?1	13.36	3	No	Yes	5	0	1	0
R:R:A157	W:W:?1	10.37	0	No	Yes	5	0	1	0
R:R:C161	R:R:F165	4.19	0	No	Yes	7	7	1	2
R:R:C161	R:R:I202	4.91	0	No	No	7	8	1	2
R:R:C161	W:W:?1	4.64	0	No	Yes	7	0	1	0
R:R:F165	R:R:W199	6.01	3	Yes	Yes	7	9	2	1
R:R:W199	W:W:?1	20	3	Yes	Yes	9	0	1	0
R:R:L203	W:W:?1	10.13	0	No	Yes	3	0	1	0
R:R:T206	R:R:Y210	4.99	0	No	No	7	5	2	1
R:R:Y210	W:W:?1	18.87	0	No	Yes	5	0	1	0
R:R:V211	W:W:?1	3.27	0	No	Yes	3	0	1	0
R:R:L203	R:R:L204	2.77	0	No	No	3	4	1	2
R:R:V211	R:R:V212	1.6	0	No	No	3	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
41.67	Single	8Y71	BMS986187	8Y71-δ-A1D6F-BMS986187-Gi1/β1/γ2
41.67	Single	9L60	MPAM-15	9L60-κ-Dynorphin-MPAM-15-Gi1/β1/γ2
35.71	Single	8Y73	MPAM-15	8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
35.71	Single	9YDQ	MIPS3614	9YDQ-δ-DADLE-MIPS3614-chim(NtGi1L-Gs-CtGi1)/β1/γ2
33.33	Single	7FEE	ZCZ011	7FEE-CB₁-CP55940-ZCZ011
33.33	Single	8IKH	PubChem 171393541	8IKH-CB₁-PubChem 171393541-Gi1/β1/γ1
26.67	Single	9YDR	MIPS3983	9YDR-δ-DADLE-MIPS3983-chim(NtGi1L-Gs-CtGi1)/β1/γ2
21.43	Single	7WV9	ZCZ011	7WV9-CB₁-CP55940-ZCZ011-Gi2/β1/γ2
21.43	Single	8G94	CD69	8G94-S1P₁-CD69-Gi1/β1/γ2
16.67	Single	6KQI	Org27569	6KQI-CB₁-CP55940-Org27569
9.09	Single	8JGB	Conorfamide-Tx2	8JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
9.09	Single	8SAI	Lysophosphatidylserine (S12)	8SAI-GPR34-Lysophosphatidylserine (S12)-Gi1/β1/γ2
7.69	Single	8IKG	PubChem 703205	8IKG-CB₁-PubChem 703205-Gi1/β1/γ1
6.25	Single	8T3V	Doconexent	8T3V-FFA1-Doconexent-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88	Single	8IYX	YL-365	8IYX-GPR34-YL-365
5.56	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/β1/γ2
5.56	Single	8XBG	S3E-Lysophosphatidylserine	8XBG-GPR34-S3E-Lysophosphatidylserine
5.26	Single	9GE2	ML184	9GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
5.00	Single	8XBI	PubChem 162656636	8XBI-GPR34-PubChem 162656636
5.00	Single	9CLW	TUG-1375	9CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00	Consensus	ffa_on	Orthosteric Ligand	ffa2_on ffa3_on
5.00	Consensus	ffa_on_gp	Orthosteric Ligand	ffa2_on_gp ffa3_on_gp
5.00	Consensus	gi_ffa	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
4.76	Single	8JPC	Neurotensin-(8-13)	8JPC-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
4.76	Single	8Y6W	TUG-1375	8Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
4.76	Single	9CM3	TUG-1375	9CM3-FFA2-TUG-1375-PubChem 118615810-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.55	Single	8XBE	S3E-Lysophosphatidylserine	8XBE-GPR34-S3E-Lysophosphatidylserine-Gi1/β1/γ1
4.55	Single	9GE3	Lysophosphatidylinositol	9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
4.35	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/β1/γ2
4.35	Single	9CM7	TUG-1375	9CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
4.35	Single	9NS9	TUG-1375	9NS9-FFA2-TUG-1375-PubChem 118615810-Gi1/β1/γ2
4.17	Single	8XBH	PubChem 162656636	8XBH-GPR34-PubChem 162656636-Gi1/β1/γ2
4.17	Single	9UYL	Chemerin-9	9UYL-CML2-Chemerin-9-Arrestin2
4.00	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
3.85	Single	8XIQ	L796778	8XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
3.57	Single	7XV3	Lysophosphatidylserine (WJS)	7XV3-GPR174-Lysophosphatidylserine (WJS)-chim(NtGi1-Gs)/β1/γ2

PDB Summary
PDB	5NDZ
Class	A
SubFamily	Peptide
Type	Proteinase Activated
SubType	PAR2
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	AZ3451; Na
Protein Partners	-
PDB Resolution	3.6
Date	2017-05-03
D.O.I.	doi.org/10.1038/nature22309

Net Summary
I_min	3.28
Number of Linked Nodes	276
Number of Links	319
Number of Hubs	44
Number of Links mediated by Hubs	170
Number of Communities	7
Number of Nodes involved in Communities	60
Number of Links involved in Communities	86

Path Summary
Number Of Nodes in MetaPath	62
Number Of Links MetaPath	61
Number of Shortest Paths	57730
Length Of Smallest Path	3
Average Path Length	15.7981
Length of Longest Path	35
Minimum Path Strength	1.38
Average Path Strength	6.44553
Maximum Path Strength	19.975
Minimum Path Correlation	0.7
Average Path Correlation	0.925881
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	44.8655
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.2837
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• hydrolase activity, acting on glycosyl bonds • peptidoglycan muralytic activity • hydrolase activity, hydrolyzing O-glycosyl compounds • lysozyme activity • hydrolase activity • catalytic activity • binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • protein binding • G-protein alpha-subunit binding • molecular transducer activity • signaling receptor activity • signaling receptor binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • enzyme binding • protease binding • peptide receptor activity • thrombin-activated receptor activity • proteinase-activated receptor activity • G protein-coupled peptide receptor activity • G-protein beta-subunit binding • defense response to bacterium • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • response to bacterium • response to stress • response to external stimulus • response to external biotic stimulus • response to biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process
Gene Ontology	Biological Process	• defense response to bacterium • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • response to bacterium • response to stress • response to external stimulus • response to external biotic stimulus • response to biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process • carbohydrate derivative metabolic process • aminoglycan catabolic process • macromolecule catabolic process • glycosaminoglycan catabolic process • aminoglycan metabolic process • peptidoglycan metabolic process • metabolic process • cellular process • macromolecule metabolic process • symbiont-mediated cytolysis of host cell • viral life cycle • disruption of cell in another organism • cytolysis • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral release from host cell by cytolysis • exit from host cell • viral process • cytolysis in another organism • viral release from host cell • disruption of anatomical structure in another organism • symbiont-mediated killing of host cell • killing of cells of another organism • cell killing • cell wall organization or biogenesis • cell wall macromolecule catabolic process • cell wall macromolecule metabolic process • electron transport chain • generation of precursor metabolites and energy • multicellular organismal process • regulation of body fluid levels • wound healing • hemostasis • biological regulation • blood coagulation • coagulation • regulation of biological quality • response to wounding • developmental process • myeloid leukocyte differentiation • cellular developmental process • hemopoiesis • cell development • mononuclear cell differentiation • myeloid cell differentiation • cell differentiation • anatomical structure development • dendritic cell differentiation • mature conventional dendritic cell differentiation • leukocyte differentiation • regulation of biological process • regulation of cellular process • reactive oxygen species metabolic process • positive regulation of biological process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • positive regulation of cellular process • cellular response to stimulus • regulation of signaling • signaling • regulation of JNK cascade • regulation of signal transduction • regulation of MAPK cascade • intracellular signal transduction • cell communication • regulation of intracellular signal transduction • regulation of response to stimulus • JNK cascade • intracellular signaling cassette • MAPK cascade • regulation of cell communication • signal transduction • regulation of cellular component organization • positive regulation of cellular component organization • cell projection organization • plasma membrane bounded cell projection assembly • cellular component biogenesis • cellular component organization • pseudopodium assembly • cellular component assembly • positive regulation of cell projection organization • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • positive regulation of cellular component biogenesis • regulation of cell projection organization • regulation of cell projection assembly • regulation of cellular component biogenesis • regulation of plasma membrane bounded cell projection assembly • positive regulation of pseudopodium assembly • regulation of pseudopodium assembly • cell projection assembly • regulation of plasma membrane bounded cell projection organization • positive regulation of plasma membrane bounded cell projection assembly • pseudopodium organization • chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • taxis • response to chemical • regulation of locomotion • locomotion • immune response • defense response to symbiont • immune system process • defense response to other organism • innate immune response • positive regulation of cell communication • positive regulation of response to biotic stimulus • positive regulation of signal transduction • pattern recognition receptor signaling pathway • immune response-activating signaling pathway • positive regulation of toll-like receptor 3 signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • innate immune response-activating signaling pathway • positive regulation of pattern recognition receptor signaling pathway • regulation of innate immune response • positive regulation of intracellular signal transduction • regulation of pattern recognition receptor signaling pathway • positive regulation of defense response • regulation of immune response • activation of innate immune response • activation of immune response • regulation of defense response • cytoplasmic pattern recognition receptor signaling pathway • regulation of response to biotic stimulus • intracellular receptor signaling pathway • regulation of cytoplasmic pattern recognition receptor signaling pathway • endolysosomal toll-like receptor signaling pathway • immune response-regulating signaling pathway • regulation of response to stress • regulation of toll-like receptor 3 signaling pathway • positive regulation of innate immune response • toll-like receptor 3 signaling pathway • positive regulation of signaling • regulation of biosynthetic process • chemokine (C-X-C motif) ligand 2 production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of chemokine production • regulation of gene expression • regulation of chemokine (C-X-C motif) ligand 2 production • biosynthetic process • regulation of cytokine production • cytokine production • chemokine production • regulation of macromolecule biosynthetic process • regulation of multicellular organismal process • negative regulation of biological process • negative regulation of chemokine production • negative regulation of cellular process • negative regulation of macromolecule metabolic process • negative regulation of metabolic process • negative regulation of cytokine production • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of multicellular organismal process • interleukin-1 production • regulation of interleukin-1 beta production • positive regulation of macromolecule biosynthetic process • positive regulation of interleukin-1 beta production • positive regulation of biosynthetic process • positive regulation of interleukin-1 production • positive regulation of macromolecule metabolic process • regulation of interleukin-1 production • interleukin-1 beta production • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of cytokine production • positive regulation of interleukin-8 production • interleukin-8 production • regulation of interleukin-8 production • positive regulation of JNK cascade • positive regulation of MAPK cascade • positive regulation of chemokine production • renal system process • system process • regulation of renal system process • regulation of system process • regulation of glomerular filtration • positive regulation of glomerular filtration • glomerular filtration • renal filtration • negative regulation of signaling • negative regulation of cytoplasmic pattern recognition receptor signaling pathway • negative regulation of intracellular signal transduction • negative regulation of cell communication • negative regulation of toll-like receptor 3 signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of immune system process • interleukin-10 production • regulation of interleukin-10 production • positive regulation of interleukin-10 production • regulation of systemic arterial blood pressure by renin-angiotensin • regulation of localization • regulation of systemic arterial blood pressure by hormone • establishment of protein localization • positive regulation of establishment of protein localization • localization • circulatory system process • renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure • intracellular protein localization • establishment of protein localization to extracellular region • regulation of systemic arterial blood pressure by circulatory renin-angiotensin • protein secretion • establishment of localization • positive regulation of renin secretion into blood stream • regulation of protein secretion • regulation of secretion • positive regulation of protein localization • regulation of endocrine process • renin secretion into blood stream • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of protein localization • transport • positive regulation of secretion by cell • protein localization to extracellular region • positive regulation of protein transport • regulation of secretion by cell • secretion by cell • regulation of renin secretion into blood stream • positive regulation of secretion • signal release • renal system process involved in regulation of systemic arterial blood pressure • blood circulation • regulation of transport • secretion • regulation of blood pressure • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • endocrine process • regulation of systemic arterial blood pressure • positive regulation of transport • protein transport • macromolecule localization • cell activation • lymphocyte activation • cell activation involved in immune response • leukocyte activation • immune effector process • T cell activation involved in immune response • T cell activation • leukocyte activation involved in immune response • lymphocyte activation involved in immune response • regulation of immune effector process • regulation of myeloid leukocyte mediated immunity • regulated exocytosis • positive regulation of leukocyte mediated immunity • leukocyte degranulation • myeloid leukocyte mediated immunity • vesicle-mediated transport • myeloid leukocyte activation • positive regulation of leukocyte degranulation • positive regulation of regulated secretory pathway • establishment of localization in cell • leukocyte mediated immunity • regulation of leukocyte mediated immunity • exocytosis • positive regulation of myeloid leukocyte mediated immunity • eosinophil mediated immunity • cellular localization • eosinophil activation • positive regulation of exocytosis • regulation of regulated secretory pathway • regulation of eosinophil degranulation • positive regulation of eosinophil degranulation • eosinophil degranulation • positive regulation of immune effector process • eosinophil activation involved in immune response • regulation of leukocyte degranulation • regulation of vesicle-mediated transport • myeloid cell activation involved in immune response • regulation of exocytosis • granulocyte activation • defense response to virus • response to virus • positive regulation of DNA-templated transcription • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • regulation of cell motility • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • cell chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • positive regulation of leukocyte migration • leukocyte migration • cellular response to chemical stimulus • leukocyte chemotaxis • cell population proliferation • leukocyte proliferation • positive regulation of cytosolic calcium ion concentration • positive regulation of canonical NF-kappaB signal transduction • canonical NF-kappaB signal transduction • regulation of canonical NF-kappaB signal transduction • immune response-regulating cell surface receptor signaling pathway • cell surface toll-like receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • regulation of toll-like receptor 4 signaling pathway • positive regulation of toll-like receptor 4 signaling pathway • innate immune response activating cell surface receptor signaling pathway • cell surface pattern recognition receptor signaling pathway • cell surface receptor signaling pathway • toll-like receptor 4 signaling pathway • positive regulation of ERK1 and ERK2 cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • import into cell • positive regulation of membrane invagination • positive regulation of endocytosis • regulation of phagocytosis, engulfment • membrane invagination • phagocytosis • plasma membrane invagination • regulation of endocytosis • membrane organization • regulation of phagocytosis • phagocytosis, engulfment • positive regulation of phagocytosis • positive regulation of phagocytosis, engulfment • regulation of membrane invagination • endocytosis • positive regulation of organelle organization • regulation of cytoskeleton organization • regulation of actin filament-based process • regulation of cellular component size • protein-containing complex disassembly • positive regulation of actin filament depolymerization • regulation of protein-containing complex disassembly • actin filament depolymerization • regulation of actin filament depolymerization • actin filament-based process • positive regulation of protein-containing complex disassembly • cellular component disassembly • actin polymerization or depolymerization • regulation of actin filament organization • actin cytoskeleton organization • protein-containing complex organization • regulation of protein depolymerization • positive regulation of protein depolymerization • positive regulation of cytoskeleton organization • actin filament organization • regulation of actin polymerization or depolymerization • positive regulation of supramolecular fiber organization • regulation of organelle organization • organelle organization • regulation of actin filament length • regulation of actin cytoskeleton organization • regulation of supramolecular fiber organization • supramolecular fiber organization • protein depolymerization • cytoskeleton organization • regulation of anatomical structure size • interleukin-6 production • positive regulation of interleukin-6 production • regulation of interleukin-6 production • neutrophil-mediated killing of symbiont cell • regulation of killing of cells of another organism • regulation of programmed cell death • positive regulation of neutrophil mediated cytotoxicity • positive regulation of leukocyte mediated cytotoxicity • positive regulation of neutrophil mediated killing of symbiont cell • regulation of neutrophil mediated killing of gram-negative bacterium • positive regulation of programmed cell death • leukocyte mediated cytotoxicity • cell death • positive regulation of neutrophil mediated killing of bacterium • regulation of cell killing • positive regulation of cell killing • positive regulation of killing of cells of another organism • positive regulation of neutrophil mediated killing of gram-negative bacterium • defense response to Gram-negative bacterium • regulation of neutrophil mediated killing of bacterium • positive regulation of defense response to bacterium • neutrophil mediated immunity • modulation of process of another organism • regulation of biological process involved in symbiotic interaction • regulation of defense response to bacterium • neutrophil-mediated killing of bacterium • neutrophil mediated cytotoxicity • regulation of neutrophil mediated cytotoxicity • regulation of leukocyte mediated cytotoxicity • regulation of neutrophil mediated killing of symbiont cell • neutrophil-mediated killing of gram-negative bacterium • programmed cell death • positive regulation of molecular function • regulation of molecular function • positive regulation of hydrolase activity • regulation of catalytic activity • regulation of hydrolase activity • positive regulation of catalytic activity • regulation of GTPase activity • positive regulation of GTPase activity • neutrophil activation • regulation of toll-like receptor 2 signaling pathway • positive regulation of toll-like receptor 2 signaling pathway • toll-like receptor 2 signaling pathway • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • positive regulation of small GTPase mediated signal transduction • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • negative regulation of protein transport • nitrogen compound transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • negative regulation of establishment of protein localization • negative regulation of protein secretion • regulation of hormone secretion • regulation of peptide secretion • hormone secretion • negative regulation of peptide secretion • peptide secretion • negative regulation of protein localization • regulation of peptide transport • peptide transport • negative regulation of insulin secretion • regulation of insulin secretion • peptide hormone secretion • hormone transport • insulin secretion • negative regulation of JNK cascade • negative regulation of MAPK cascade • regulation of tube diameter • regulation of tube size • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • positive chemotaxis • positive regulation of positive chemotaxis • regulation of positive chemotaxis • epithelium development • endothelial cell differentiation • endothelium development • tissue development • epithelial cell differentiation • endothelial cell development • epithelial cell development • establishment of endothelial barrier • cell junction maintenance • cell junction organization • cellular component maintenance • cell-cell junction maintenance • cell-cell junction organization • inflammatory response • G protein-coupled receptor signaling pathway • regulation of blood coagulation • regulation of coagulation • regulation of response to wounding • regulation of wound healing • regulation of hemostasis • cytokine production involved in immune response • production of molecular mediator of immune response • regulation of cytokine production involved in immune response • positive regulation of cytokine production involved in immune response • positive regulation of production of molecular mediator of immune response • regulation of production of molecular mediator of immune response • response to cytokine • cytokine-mediated signaling pathway • cellular response to tumor necrosis factor • tumor necrosis factor-mediated signaling pathway • cellular response to cytokine stimulus • regulation of tumor necrosis factor-mediated signaling pathway • regulation of cytokine-mediated signaling pathway • negative regulation of tumor necrosis factor-mediated signaling pathway • response to peptide • regulation of response to cytokine stimulus • negative regulation of response to cytokine stimulus • negative regulation of cytokine-mediated signaling pathway • response to tumor necrosis factor • regulation of type II interferon production • type II interferon production • positive regulation of type II interferon production • host cellular component • host intracellular part • cellular anatomical structure • host cell cytoplasm • host cell part • host intracellular region • other organism part • periplasmic space • cell projection • pseudopodium • plasma membrane bounded cell projection • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure
Gene Ontology	Cellular Component	• host cellular component • host intracellular part • cellular anatomical structure • host cell cytoplasm • host cell part • host intracellular region • other organism part • periplasmic space • cell projection • pseudopodium • plasma membrane bounded cell projection • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • Golgi apparatus • organelle • cytoplasm • intracellular membrane-bounded organelle • endomembrane system • cell periphery • plasma membrane • membrane • early endosome • endosome • intracellular vesicle • cytoplasmic vesicle • vesicle
SCOP2	Domain Identifier	• Cytochromes • G protein-coupled receptor-like
SCOP2	Family Identifier	• Cytochromes • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	8UN
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	8UN
Name	2-(6-bromanyl-1,3-benzodioxol-5-yl)-~{N}-(4-cyanophenyl)-1-[(1~{S})-1-cyclohexylethyl]benzimidazole-5-carboxamide
Synonyms
Identifier
Formula	C30 H27 Br N4 O3
Molecular Weight	571.464
SMILES
PubChem	126961335
Formal Charge	0
Total Atoms	65
Total Chiral Atoms	1
Total Bonds	70
Total Aromatic Bonds	22


Code	NA
PDB Residues	I:I:?1
Environment Details	Open EMBL-EBI Page
Code	NA
Name	SODIUM ION
Synonyms
Identifier
Formula	Na
Molecular Weight	22.99
SMILES
PubChem
Formal Charge	1
Total Atoms	1
Total Chiral Atoms	0
Total Bonds	0
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P55085
Sequence	>5NDZ_Chain_R F S V D E F S A S V L T G K L T T V F L P I V Y T I V F V V A L P S N G M A L W V F L F R T K K K A P A V I Y M A N L A L A D L L S V I W F P L K I A Y H I H G N N W I Y G E A L C N V L I G F F Y A N M Y C S I L F L T C L S V Q R A W E I V N P M G H S R K K A N I A I G I S L A I W L L I L L V T I P L Y V V K Q T I F I P A L Q I T T C H D V L P E Q L L V G D M F N Y F L S L A I G V F L F P A F L T A S A Y V L M I R A L E N S E K K R K R A I K L A V T V A A M Y L I C F T P S N L L L V V H Y F L I K S Q G Q S H V Y A L Y I V A L C L S T L N S C I D P F V Y Y F V S H D F R D H A K N A L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5NDD	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	AZ8838; Na	-	2.8	2017-05-03	doi.org/10.1038/nature22309
	5NDZ	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	AZ3451; Na	-	3.6	2017-05-03	doi.org/10.1038/nature22309
	5NJ6	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-	-	4	2017-05-03	doi.org/10.1038/nature22309
	9D0A	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.1	2025-05-07	doi.org/10.1038/s41467-025-59138-x
	9D0A (No Gprot)	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-		3.1	2025-05-07	doi.org/10.1038/s41467-025-59138-x
	9E7R	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	GB88	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.18	2025-05-07	doi.org/10.1038/s41467-025-59138-x
	9E7R (No Gprot)	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	GB88	-		3.18	2025-05-07	doi.org/10.1038/s41467-025-59138-x
	8ZMD	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.25	2025-05-28	To be published
	8ZMD (No Gprot)	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-		3.25	2025-05-28	To be published
	8ZME	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.2	2025-05-28	To be published
	8ZME (No Gprot)	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-		3.2	2025-05-28	To be published

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.