psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H310	R:R:S37	2.79	Yes	No	0	4	8
2	R:R:S37	R:R:Y323	2.54	No	Yes	0	8	4
3	R:R:L38	R:R:S65	7.51	No	No	0	8	5
4	R:R:L38	R:R:S320	3	No	No	0	8	2
5	R:R:L38	R:R:Y323	2.34	No	Yes	0	8	4
6	R:R:E232	R:R:I39	6.83	No	No	0	1	7
7	R:R:F59	R:R:G40	4.52	No	No	0	7	6
8	R:R:E232	R:R:K41	12.15	No	No	0	1	7
9	R:R:F59	R:R:I216	7.54	No	No	4	7	1
10	R:R:F59	R:R:P231	4.33	No	No	4	7	4
11	R:R:S65	R:R:V61	3.23	No	No	0	5	6
12	R:R:I218	R:R:V61	3.07	No	No	0	4	6
13	R:R:D62	R:R:S65	4.42	No	No	0	7	5
14	R:R:F64	R:R:V68	2.62	No	No	0	2	4
15	R:R:L69	R:R:N139	8.24	No	No	0	4	5
16	R:R:L221	R:R:T70	2.95	No	No	0	3	7
17	R:R:T75	R:R:V76	4.76	No	No	0	5	4
18	R:R:F77	R:R:V81	2.62	No	No	0	4	6
19	R:R:L78	R:R:Y82	2.34	Yes	No	0	5	7
20	R:R:H135	R:R:L78	3.86	No	Yes	0	5	5
21	R:R:I327	R:R:L78	4.28	No	Yes	0	4	5
22	R:R:I132	R:R:P79	3.39	No	No	0	7	5
23	R:R:F128	R:R:Y82	6.19	No	No	0	8	7
24	R:R:T334	R:R:Y82	2.5	No	No	0	7	7
25	R:R:T334	R:R:V85	4.76	No	No	0	7	8
26	R:R:C338	R:R:V85	5.12	No	No	0	7	8
27	R:R:F86	R:R:L90	15.83	Yes	No	5	6	6
28	R:R:F86	R:R:V125	5.24	Yes	No	5	6	6
29	R:R:F86	R:R:P129	7.22	Yes	No	0	6	8
30	R:R:C338	R:R:V88	6.83	No	No	0	7	6
31	R:R:L90	R:R:P91	3.28	No	No	0	6	5
32	R:R:L90	R:R:V125	8.94	No	No	5	6	6
33	R:R:A118	R:R:N93	3.13	No	No	0	8	9
34	R:R:D121	R:R:N93	13.46	Yes	No	0	9	9
35	R:R:N93	R:R:P341	6.52	No	No	0	9	9
36	R:R:G94	R:R:L122	3.42	No	No	0	4	8
37	R:R:M95	R:R:W98	3.49	No	Yes	0	6	3
38	R:R:A96	R:R:Y345	2.67	No	Yes	0	9	7
39	R:R:A118	R:R:L97	3.15	No	No	0	8	7
40	R:R:L119	R:R:L97	5.54	No	No	0	6	7
41	R:R:L122	R:R:L97	2.77	No	No	0	8	7
42	R:R:F102	R:R:W98	10.02	No	Yes	0	4	3
43	R:R:R103	R:R:W98	10	No	Yes	6	5	3
44	R:R:A358	R:R:W98	2.59	No	Yes	6	5	3
45	R:R:F351	R:R:V99	6.55	Yes	No	0	8	8
46	R:R:F100	R:R:V111	10.49	Yes	No	0	6	7
47	R:R:F100	R:R:M114	9.95	Yes	Yes	2	6	8
48	R:R:A115	R:R:F100	4.16	No	Yes	0	7	6
49	R:R:F100	R:R:Y345	8.25	Yes	Yes	2	6	7
50	R:R:F100	R:R:F351	11.79	Yes	Yes	2	6	8
51	R:R:F102	R:R:L101	2.44	No	No	0	4	4
52	R:R:A358	R:R:R103	4.15	No	No	6	5	5
53	R:R:T104	R:R:V111	11.11	No	No	0	6	7
54	R:R:H108	R:R:K106	10.48	No	No	0	7	7
55	R:R:A188	R:R:K107	3.21	No	No	0	3	6
56	R:R:P109	R:R:Y113	2.78	Yes	Yes	1	7	7
57	R:R:P109	R:R:Q172	4.74	Yes	No	1	7	8
58	R:R:K187	R:R:P109	6.69	No	Yes	0	6	7
59	R:R:A191	R:R:I112	4.87	No	No	0	8	6
60	R:R:I112	R:R:I192	2.94	No	No	0	6	3
61	R:R:C168	R:R:Y113	5.38	No	Yes	1	7	7
62	R:R:Q172	R:R:Y113	6.76	No	Yes	1	8	7
63	R:R:A191	R:R:Y113	4	No	Yes	0	8	7
64	R:R:L169	R:R:M114	5.65	No	Yes	0	8	8
65	R:R:M114	R:R:Y345	11.97	Yes	Yes	2	8	7
66	R:R:F165	R:R:N116	13.29	Yes	No	1	7	9
67	R:R:N116	R:R:S195	5.96	No	No	1	9	7
68	R:R:D121	R:R:L117	2.71	Yes	No	2	9	9
69	R:R:L117	R:R:S162	3	No	No	2	9	9
70	R:R:L117	R:R:Y345	3.52	No	Yes	2	9	7
71	R:R:L119	R:R:L123	4.15	No	No	0	6	7
72	R:R:L119	R:R:W199	5.69	No	No	0	6	9
73	R:R:A120	R:R:C161	3.61	No	Yes	0	8	7
74	R:R:D121	R:R:S162	5.89	Yes	No	2	9	9
75	R:R:D121	R:R:S337	4.42	Yes	No	0	9	9
76	R:R:L123	R:R:N158	4.12	No	No	0	7	8
77	R:R:N158	R:R:S124	5.96	No	No	0	8	7
78	R:R:S337	R:R:V125	3.23	No	No	0	9	6
79	R:R:I126	R:R:W127	12.92	No	No	0	5	7
80	R:R:V150	R:R:W127	6.13	No	No	7	5	7
81	R:R:F154	R:R:W127	19.04	No	No	7	5	7
82	R:R:F128	R:R:F155	6.43	No	No	0	8	6
83	R:R:L130	R:R:Y143	7.03	No	Yes	0	7	7
84	R:R:H135	R:R:K131	10.48	No	No	0	5	7
85	R:R:K131	R:R:L151	2.82	No	No	0	7	5
86	R:R:H135	R:R:Y134	6.53	No	Yes	0	5	5
87	R:R:N139	R:R:Y134	11.63	No	Yes	0	5	5
88	R:R:W141	R:R:Y134	9.65	Yes	Yes	0	9	5
89	R:R:T225	R:R:Y134	2.5	No	Yes	0	4	5
90	R:R:D228	R:R:Y134	6.9	No	Yes	0	4	5
91	R:R:I223	R:R:N140	15.58	No	No	0	3	4
92	R:R:W141	R:R:Y143	11.58	Yes	Yes	0	9	7
93	R:R:C148	R:R:W141	2.61	No	Yes	8	9	9
94	R:R:C226	R:R:W141	2.61	No	Yes	8	9	9
95	R:R:I142	R:R:Y143	14.51	No	Yes	0	1	7
96	R:R:E145	R:R:N149	17.09	No	No	0	3	6
97	R:R:E145	R:R:K213	2.7	No	No	0	3	5
98	R:R:C148	R:R:C226	7.28	No	No	8	9	9
99	R:R:N149	R:R:Y210	4.65	No	No	0	6	5
100	R:R:N149	R:R:Q214	2.64	No	No	0	6	4
101	R:R:F154	R:R:V150	3.93	No	No	7	5	5
102	R:R:I152	R:R:L209	5.71	No	No	0	5	4
103	R:R:H227	R:R:I152	14.58	No	No	0	5	5
104	R:R:G153	R:R:L209	3.42	No	No	0	6	4
105	R:R:G153	R:R:Y210	4.35	No	No	0	6	5
106	R:R:F154	R:R:N158	2.42	No	No	0	5	8
107	R:R:F155	R:R:Y156	3.09	No	No	0	6	5
108	R:R:F155	R:R:L330	2.44	No	No	0	6	5
109	R:R:Y156	R:R:Y160	2.98	No	No	0	5	7
110	R:R:F243	R:R:Y156	8.25	Yes	No	0	6	5
111	R:R:M159	R:R:S333	3.07	No	No	0	7	8
112	R:R:I163	R:R:Y160	2.42	No	No	0	7	7
113	R:R:L246	R:R:Y160	4.69	No	No	0	5	7
114	R:R:C161	R:R:F165	4.19	Yes	Yes	1	7	7
115	R:R:C161	R:R:W199	6.53	Yes	No	1	7	9
116	R:R:C161	R:R:I202	3.27	Yes	Yes	1	7	8
117	R:R:F251	R:R:I163	3.77	Yes	No	0	8	7
118	R:R:I163	R:R:Y296	6.04	No	Yes	0	7	9
119	R:R:I198	R:R:L164	4.28	Yes	No	1	7	6
120	R:R:I202	R:R:L164	2.85	Yes	No	1	8	6
121	R:R:L164	R:R:V250	2.98	No	No	0	6	5
122	R:R:F165	R:R:S195	5.28	Yes	No	1	7	7
123	R:R:F165	R:R:W199	4.01	Yes	No	1	7	9
124	R:R:M166	R:R:Y296	4.79	No	Yes	0	8	9
125	R:R:D340	R:R:M166	4.16	No	No	0	9	8
126	R:R:M166	R:R:Y344	7.18	No	No	0	8	9
127	R:R:P254	R:R:T167	6.99	No	No	0	9	7
128	R:R:T167	R:R:T258	4.71	No	No	0	7	8
129	R:R:L169	R:R:Y344	2.34	No	No	0	8	9
130	R:R:S170	R:R:T258	7.99	No	No	3	9	8
131	R:R:S170	R:R:Y262	13.99	No	Yes	3	9	9
132	R:R:R173	R:R:Y262	6.17	No	Yes	3	9	9
133	R:R:M265	R:R:R173	2.48	No	No	3	8	9
134	R:R:V178	R:R:Y174	16.4	No	No	0	7	8
135	R:R:L264	R:R:Y174	2.34	No	No	0	4	8
136	R:R:I177	R:R:M268	2.92	No	No	0	8	5
137	R:R:M268	R:R:V178	4.56	No	No	0	5	7
138	R:R:N179	R:R:P180	6.52	No	No	0	6	8
139	R:R:K186	R:R:N189	5.6	No	No	0	7	4
140	R:R:I190	R:R:K186	10.18	No	No	0	4	7
141	R:R:I194	R:R:I198	2.94	No	Yes	1	5	7
142	R:R:I198	R:R:I202	2.94	Yes	Yes	1	7	8
143	R:R:I207	R:R:P208	3.39	No	No	0	4	7
144	R:R:L209	R:R:Y242	11.72	No	Yes	0	4	5
145	R:R:Q214	R:R:V212	2.87	No	No	0	4	4
146	R:R:L234	R:R:V212	4.47	No	No	0	5	4
147	R:R:K213	R:R:T215	6.01	No	No	0	5	4
148	R:R:H227	R:R:Q214	3.71	No	No	0	5	4
149	R:R:I216	R:R:P231	5.08	No	No	4	1	4
150	R:R:F217	R:R:P219	7.22	No	No	0	1	1
151	R:R:F217	R:R:N222	2.42	No	No	0	1	5
152	R:R:F217	R:R:T224	6.49	No	No	0	1	5
153	R:R:I218	R:R:P219	3.39	No	No	0	4	1
154	R:R:I218	R:R:V229	4.61	No	No	0	4	4
155	R:R:I223	R:R:L221	5.71	No	No	0	3	3
156	R:R:T225	R:R:V229	4.76	No	No	0	4	4
157	R:R:D228	R:R:Y323	5.75	No	Yes	0	4	4
158	R:R:L230	R:R:P231	4.93	No	No	0	5	4
159	R:R:L230	R:R:L234	2.77	No	No	0	5	5
160	R:R:L230	R:R:L235	2.77	No	No	0	5	4
161	R:R:L234	R:R:M239	5.65	No	No	0	5	4
162	R:R:I314	R:R:L235	4.28	No	No	0	2	4
163	R:R:K315	R:R:V236	7.59	No	No	0	2	3
164	R:R:M239	R:R:Y242	3.59	No	Yes	9	4	5
165	R:R:F243	R:R:M239	3.73	Yes	No	9	6	4
166	R:R:F240	R:R:L244	3.65	No	No	0	3	5
167	R:R:F240	R:R:Y311	4.13	No	No	0	3	5
168	R:R:F240	R:R:K315	9.93	No	No	0	3	2
169	R:R:F243	R:R:Y242	4.13	Yes	Yes	9	6	5
170	R:R:L246	R:R:Y242	8.21	No	Yes	0	5	5
171	R:R:F243	R:R:Y311	9.28	Yes	No	0	6	5
172	R:R:I248	R:R:L252	4.28	No	No	0	4	4
173	R:R:F253	R:R:G249	3.01	No	No	0	6	5
174	R:R:F251	R:R:L252	3.65	Yes	No	0	8	4
175	R:R:F251	R:R:F300	3.22	Yes	No	0	8	9
176	R:R:F251	R:R:T301	6.49	Yes	Yes	0	8	5
177	R:R:F251	R:R:N304	12.08	Yes	No	0	8	8
178	R:R:F253	R:R:P254	2.89	No	No	0	6	9
179	R:R:A255	R:R:Y296	2.67	No	Yes	0	7	9
180	R:R:T258	R:R:Y262	2.5	No	Yes	3	8	9
181	R:R:L264	R:R:S260	3	No	No	0	4	4
182	R:R:M265	R:R:Y262	2.39	No	Yes	3	8	9
183	R:R:I289	R:R:Y262	6.04	No	Yes	0	8	9
184	R:R:L293	R:R:Y262	3.52	No	Yes	0	8	9
185	R:R:R267	R:R:V263	2.62	No	No	0	4	3
186	R:R:L264	R:R:R267	2.43	No	No	0	4	4
187	R:R:I266	R:R:I286	4.42	No	No	0	5	6
188	R:R:I266	R:R:I289	5.89	No	No	0	5	8
189	R:R:I286	R:R:R270	2.51	No	No	0	6	4
190	R:R:M274	R:R:R282	11.17	No	No	0	4	6
191	R:R:D275	R:R:N277	10.77	No	No	0	4	4
192	R:R:R282	R:R:S278	5.27	No	No	0	6	4
193	R:R:E279	R:R:K283	8.1	No	No	0	3	5
194	R:R:H349	R:R:R284	5.64	No	No	0	5	7
195	R:R:L288	R:R:V347	4.47	No	No	0	8	7
196	R:R:T291	R:R:V343	3.17	No	No	0	5	8
197	R:R:V292	R:R:Y344	5.05	No	No	0	8	9
198	R:R:L293	R:R:L297	2.77	No	No	0	8	5
199	R:R:I339	R:R:M295	7.29	No	No	0	6	6
200	R:R:L297	R:R:Y296	3.52	No	Yes	0	5	9
201	R:R:L297	R:R:T301	2.95	No	Yes	0	5	5
202	R:R:C299	R:R:N336	9.45	No	No	0	9	9
203	R:R:F300	R:R:N336	12.08	No	No	0	9	9
204	R:R:P302	R:R:T301	3.5	No	Yes	0	9	5
205	R:R:L305	R:R:T301	2.95	No	Yes	0	6	5
206	R:R:N304	R:R:S303	2.98	No	No	0	8	7
207	R:R:S303	R:R:S333	4.89	No	No	0	7	8
208	R:R:L306	R:R:L325	4.15	No	No	0	4	5
209	R:R:L307	R:R:Y326	8.21	No	No	0	5	4
210	R:R:H310	R:R:Y311	5.44	Yes	No	0	4	5
211	R:R:H310	R:R:I314	2.65	Yes	No	0	4	2
212	R:R:H310	R:R:S320	5.58	Yes	No	0	4	2
213	R:R:H310	R:R:V322	5.54	Yes	No	0	4	4
214	R:R:H321	R:R:L313	2.57	No	No	0	4	1
215	R:R:Q317	R:R:S316	7.22	No	No	0	1	1
216	R:R:H321	R:R:Q319	2.47	No	No	0	4	4
217	R:R:H321	R:R:V322	2.77	No	No	0	4	4
218	R:R:I327	R:R:Y323	8.46	No	Yes	0	4	4
219	R:R:L330	R:R:Y326	8.21	No	No	0	5	4
220	R:R:L330	R:R:S333	4.5	No	No	0	5	8
221	R:R:D340	R:R:N336	5.39	No	No	0	9	9
222	R:R:P341	R:R:Y345	5.56	No	Yes	0	9	7
223	R:R:F342	R:R:F346	5.36	No	No	0	6	7
224	R:R:F351	R:R:Y345	3.09	Yes	Yes	2	8	7
225	R:R:D350	R:R:S348	2.94	No	No	0	6	8
226	R:R:F351	R:R:S348	2.64	Yes	No	0	8	8
227	R:R:D353	R:R:H354	11.35	No	No	0	4	5
228	R:R:K187	R:R:W175	2.32	No	No	0	6	5
229	R:R:L147	R:R:W141	2.28	No	Yes	0	6	9
230	R:R:H137	R:R:Y143	2.18	No	Yes	0	4	7
231	R:R:F346	R:R:F351	2.14	No	Yes	0	7	8
232	R:R:C338	R:R:G89	1.96	No	No	0	7	8
233	R:R:A188	R:R:P109	1.87	No	Yes	0	3	7
234	R:R:G157	R:R:T206	1.82	No	No	0	5	7
235	R:R:G157	R:R:I202	1.76	No	Yes	0	5	8
236	R:R:G193	R:R:I192	1.76	No	No	0	2	3
237	R:R:C331	R:R:V81	1.71	No	No	0	6	6
238	R:R:A261	R:R:S170	1.71	No	No	0	7	9
239	R:R:A273	R:R:S271	1.71	No	No	0	4	4
240	R:R:A355	R:R:V99	1.7	No	No	0	7	8
241	R:R:G138	R:R:N139	1.7	No	No	0	4	5
242	R:R:A247	R:R:V308	1.7	No	No	0	5	6
243	R:R:L78	R:R:P79	1.64	Yes	No	0	5	5
244	R:R:C168	R:R:I194	1.64	No	No	1	7	5
245	R:R:C168	R:R:I198	1.64	No	Yes	1	7	7
246	R:R:L332	R:R:P302	1.64	No	No	0	8	9
247	R:R:G318	R:R:Q317	1.64	No	No	0	1	1
248	R:R:C299	R:R:M295	1.62	No	No	0	9	6
249	R:R:A110	R:R:M114	1.61	No	Yes	0	8	8
250	R:R:V211	R:R:V212	1.6	No	No	0	3	4
251	R:R:V292	R:R:V343	1.6	No	No	0	8	8
252	R:R:T57	R:R:V42	1.59	No	No	0	3	5
253	R:R:T74	R:R:V68	1.59	Yes	No	0	4	4
254	R:R:C331	R:R:L78	1.59	No	Yes	0	6	5
255	R:R:T83	R:R:V87	1.59	No	No	0	5	5
256	R:R:A324	R:R:L73	1.58	No	No	0	1	3
257	R:R:A247	R:R:L307	1.58	No	No	0	5	5
258	R:R:A285	R:R:L269	1.58	No	No	0	7	8
259	R:R:A329	R:R:L306	1.58	No	No	0	7	4
260	R:R:T74	R:R:T75	1.57	Yes	No	0	4	5
261	R:R:A358	R:R:N357	1.56	No	No	0	5	4
262	R:R:I84	R:R:V88	1.54	No	No	0	5	6
263	R:R:I207	R:R:V211	1.54	No	No	0	4	3
264	R:R:I266	R:R:V290	1.54	No	No	0	5	5
265	R:R:H108	R:R:P109	1.53	No	Yes	0	7	7
266	R:R:M274	R:R:S271	1.53	No	No	0	4	4
267	R:R:K72	R:R:V76	1.52	No	No	0	2	4
268	R:R:I327	R:R:T74	1.52	No	Yes	0	4	4
269	R:R:M95	R:R:V99	1.52	No	No	0	6	8
270	R:R:I223	R:R:T225	1.52	No	No	0	3	4
271	R:R:L335	R:R:V85	1.49	No	No	0	5	8
272	R:R:N241	R:R:S245	1.49	No	No	0	3	3
273	R:R:L325	R:R:V322	1.49	No	No	0	5	4
274	R:R:N179	R:R:V178	1.48	No	No	0	6	7
275	R:R:I314	R:R:I39	1.47	No	No	0	2	7
276	R:R:L73	R:R:T74	1.47	No	Yes	0	3	4
277	R:R:I80	R:R:I84	1.47	No	No	0	5	5
278	R:R:L257	R:R:T167	1.47	No	No	0	7	7
279	R:R:I190	R:R:I194	1.47	No	No	0	4	5
280	R:R:L288	R:R:T291	1.47	No	No	0	8	5
281	R:R:K105	R:R:K106	1.44	No	No	0	6	7
282	R:R:Q172	R:R:V176	1.43	No	No	0	8	8
283	R:R:I192	R:R:L196	1.43	No	No	0	3	5
284	R:R:I286	R:R:L269	1.43	No	No	0	6	8
285	R:R:G144	R:R:W141	1.41	No	Yes	0	8	9
286	R:R:A133	R:R:Y143	1.33	No	Yes	0	4	7
287	R:R:A261	R:R:Y174	1.33	No	No	0	7	8
288	R:R:D350	R:R:D353	1.33	No	No	0	6	4
289	R:R:F86	R:R:V87	1.31	Yes	No	0	6	5
290	R:R:D62	R:R:E63	1.3	No	No	0	7	5
291	R:R:K356	R:R:R352	1.24	No	No	0	4	8
292	R:R:L269	R:R:R282	1.21	No	No	0	8	6
293	R:R:L288	R:R:R284	1.21	No	No	0	8	7
294	R:R:N241	R:R:Y242	1.16	No	Yes	0	3	5
295	R:R:H349	R:R:R352	1.13	No	No	0	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T74	1.5375	4	0	4
2	R:R:L78	2.742	5	0	5
3	R:R:F86	7.4	4	5	6
4	R:R:W98	6.525	4	6	3
5	R:R:F100	8.928	5	2	6
6	R:R:P109	3.522	5	1	7
7	R:R:Y113	4.73	4	1	7
8	R:R:M114	7.295	4	2	8
9	R:R:D121	6.62	4	2	9
10	R:R:Y134	7.442	5	0	5
11	R:R:W141	5.02333	6	8	9
12	R:R:Y143	7.326	5	0	7
13	R:R:C161	4.4	4	1	7
14	R:R:F165	6.6925	4	1	7
15	R:R:I198	2.95	4	1	7
16	R:R:I202	2.705	4	1	8
17	R:R:Y242	5.762	5	9	5
18	R:R:F243	6.3475	4	9	6
19	R:R:F251	5.842	5	0	8
20	R:R:Y262	5.76833	6	3	9
21	R:R:Y296	4.255	4	0	9
22	R:R:T301	3.9725	4	0	5
23	R:R:H310	4.4	5	0	4
24	R:R:Y323	4.7725	4	0	4
25	R:R:Y345	5.84333	6	2	7
26	R:R:F351	5.242	5	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H310	R:R:S320	12.3245	5.58	Yes	No	0	4	2
2	R:R:L38	R:R:S320	11.5045	3	No	No	0	8	2
3	R:R:L38	R:R:S65	11.4514	7.51	No	No	0	8	5
4	R:R:H310	R:R:I314	10.4433	2.65	Yes	No	0	4	2
5	R:R:I327	R:R:T74	11.7698	1.52	No	Yes	0	4	4
6	R:R:S37	R:R:Y323	12.4114	2.54	No	Yes	0	8	4
7	R:R:H310	R:R:S37	13.1783	2.79	Yes	No	0	4	8
8	R:R:I327	R:R:L78	11.8325	4.28	No	Yes	0	4	5
9	R:R:L78	R:R:Y82	36.5974	2.34	Yes	No	0	5	7
10	R:R:H135	R:R:L78	23.6023	3.86	No	Yes	0	5	5
11	R:R:H135	R:R:Y134	20.766	6.53	No	Yes	0	5	5
12	R:R:F128	R:R:F155	43.5821	6.43	No	No	0	8	6
13	R:R:F155	R:R:Y156	47.5423	3.09	No	No	0	6	5
14	R:R:F243	R:R:Y156	41.4886	8.25	Yes	No	0	6	5
15	R:R:F243	R:R:Y311	33.8141	9.28	Yes	No	0	6	5
16	R:R:H310	R:R:Y311	30.4616	5.44	Yes	No	0	4	5
17	R:R:T334	R:R:Y82	10.6459	2.5	No	No	0	7	7
18	R:R:D121	R:R:S337	10.4144	4.42	Yes	No	0	9	9
19	R:R:L117	R:R:Y345	11.6637	3.52	No	Yes	2	9	7
20	R:R:M114	R:R:Y345	72.4229	11.97	Yes	Yes	2	8	7
21	R:R:L169	R:R:M114	92.3496	5.65	No	Yes	0	8	8
22	R:R:L169	R:R:Y344	92.832	2.34	No	No	0	8	9
23	R:R:M166	R:R:Y344	96.9418	7.18	No	No	0	8	9
24	R:R:M166	R:R:Y296	95.6731	4.79	No	Yes	0	8	9
25	R:R:I163	R:R:Y296	96.2761	6.04	No	Yes	0	7	9
26	R:R:I163	R:R:Y160	100	2.42	No	No	0	7	7
27	R:R:Y156	R:R:Y160	78.9783	2.98	No	No	0	5	7
28	R:R:A118	R:R:N93	50.4896	3.13	No	No	0	8	9
29	R:R:N93	R:R:P341	48.9991	6.52	No	No	0	9	9
30	R:R:P341	R:R:Y345	49.7998	5.56	No	Yes	0	9	7
31	R:R:A118	R:R:L97	49.5779	3.15	No	No	0	8	7
32	R:R:F100	R:R:M114	18.9571	9.95	Yes	Yes	2	6	8
33	R:R:F100	R:R:F351	15.5082	11.79	Yes	Yes	2	6	8
34	R:R:F351	R:R:V99	20.1968	6.55	Yes	No	0	8	8
35	R:R:M95	R:R:V99	15.8314	1.52	No	No	0	6	8
36	R:R:F351	R:R:Y345	19.8399	3.09	Yes	Yes	2	8	7
37	R:R:M95	R:R:W98	13.598	3.49	No	Yes	0	6	3
38	R:R:L119	R:R:L97	46.785	5.54	No	No	0	6	7
39	R:R:P109	R:R:Y113	10.2841	2.78	Yes	Yes	1	7	7
40	R:R:C168	R:R:Y113	20.163	5.38	No	Yes	1	7	7
41	R:R:C168	R:R:I198	21.012	1.64	No	Yes	1	7	7
42	R:R:I198	R:R:I202	26.8969	2.94	Yes	Yes	1	7	8
43	R:R:C161	R:R:I202	32.6323	3.27	Yes	Yes	1	7	8
44	R:R:C161	R:R:W199	34.3544	6.53	Yes	No	1	7	9
45	R:R:L119	R:R:W199	38.9079	5.69	No	No	0	6	9
46	R:R:W141	R:R:Y134	14.1286	9.65	Yes	Yes	0	9	5
47	R:R:L209	R:R:Y242	11.9435	11.72	No	Yes	0	4	5
48	R:R:L234	R:R:V212	14.6737	4.47	No	No	0	5	4
49	R:R:L234	R:R:M239	24.2005	5.65	No	No	0	5	4
50	R:R:F243	R:R:M239	15.5371	3.73	Yes	No	9	6	4
51	R:R:L230	R:R:L234	13.4822	2.77	No	No	0	5	5
52	R:R:L246	R:R:Y242	20.8046	8.21	No	Yes	0	5	5
53	R:R:F251	R:R:I163	11.4707	3.77	Yes	No	0	8	7
54	R:R:L297	R:R:Y296	43.5965	3.52	No	Yes	0	5	9
55	R:R:L293	R:R:L297	43.8329	2.77	No	No	0	8	5
56	R:R:L293	R:R:Y262	42.6849	3.52	No	Yes	0	8	9
57	R:R:S170	R:R:Y262	16.4295	13.99	No	Yes	3	9	9
58	R:R:A261	R:R:S170	15.4262	1.71	No	No	0	7	9
59	R:R:A261	R:R:Y174	14.0659	1.33	No	No	0	7	8
60	R:R:I289	R:R:Y262	16.7334	6.04	No	Yes	0	8	9
61	R:R:I266	R:R:I289	15.3731	5.89	No	No	0	5	8
62	R:R:I266	R:R:I286	12.6333	4.42	No	No	0	5	6
63	R:R:V292	R:R:Y344	12.2522	5.05	No	No	0	8	9
64	R:R:V292	R:R:V343	10.9498	1.6	No	No	0	8	8
65	R:R:F128	R:R:Y82	42.8055	6.19	No	No	0	8	7
66	R:R:M239	R:R:Y242	10.6121	3.59	No	Yes	9	4	5
67	R:R:L246	R:R:Y160	21.3883	4.69	No	No	0	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8ZME_nogp

PDB Summary
PDB	8ZME_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.34
Number of Linked Nodes	272
Number of Links	295
Number of Hubs	26
Number of Links mediated by Hubs	106
Number of Communities	9
Number of Nodes involved in Communities	43
Number of Links involved in Communities	50

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	41049
Length Of Smallest Path	3
Average Path Length	15.2773
Length of Longest Path	35
Minimum Path Strength	1.185
Average Path Strength	4.91057
Maximum Path Strength	15.98
Minimum Path Correlation	0.7
Average Path Correlation	0.928161
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	47.3311
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	26.5818
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P55085
Sequence	>8ZME_nogp_Chain_R S L I G K V T V F S V D E F S A S V L T G K L T T V F L P I V Y T I V F V V G L P S N G M A L W V F L F R T K K K H P A V I Y M A N L A L A D L L S V I W F P L K I A Y H I H G N N W I Y G E A L C N V L I G F F Y G N M Y C S I L F M T C L S V Q R Y W V I V N P K K A N I A I G I S L A I W L L I L L V T I P L Y V V K Q T I F I P A L N I T T C H D V L P E Q L L V G D M F N Y F L S L A I G V F L F P A F L T A S A Y V L M I R M L R S S A M D E N S E K K R K R A I K L I V T V L A M Y L I C F T P S N L L L V V H Y F L I K S Q G Q S H V Y A L Y I V A L C L S T L N S C I D P F V Y Y F V S H D F R D H A K N A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5NDD	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	AZ8838; Na	-	2.8	2017-05-03	doi.org/10.1038/nature22309
	5NDZ	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	AZ3451; Na	-	3.6	2017-05-03	doi.org/10.1038/nature22309
	5NJ6	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-	-	4	2017-05-03	doi.org/10.1038/nature22309
	9D0A	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.1	2025-05-07	doi.org/10.1038/s41467-025-59138-x
	9D0A (No Gprot)	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-		3.1	2025-05-07	doi.org/10.1038/s41467-025-59138-x
	9E7R	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	GB88	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.18	2025-05-07	doi.org/10.1038/s41467-025-59138-x
	9E7R (No Gprot)	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	GB88	-		3.18	2025-05-07	doi.org/10.1038/s41467-025-59138-x
	8ZMD	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.25	2025-05-28	To be published
	8ZMD (No Gprot)	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-		3.25	2025-05-28	To be published
	8ZME	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.2	2025-05-28	To be published
	8ZME (No Gprot)	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-		3.2	2025-05-28	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8ZME_nogp.zip

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