psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H310	R:R:S37	2.79	Yes	No	0	4	8
2	R:R:S37	R:R:Y323	2.54	No	Yes	0	8	4
3	R:R:L38	R:R:S65	7.51	No	No	0	8	5
4	R:R:L38	R:R:S320	3	No	No	0	8	2
5	R:R:L38	R:R:Y323	2.34	No	Yes	0	8	4
6	R:R:E232	R:R:I39	6.83	No	No	0	1	7
7	R:R:F59	R:R:G40	4.52	No	No	0	7	6
8	R:R:E232	R:R:K41	12.15	No	No	0	1	7
9	R:R:F59	R:R:I216	7.54	No	No	4	7	1
10	R:R:F59	R:R:P231	4.33	No	No	4	7	4
11	R:R:S65	R:R:V61	3.23	No	No	0	5	6
12	R:R:I218	R:R:V61	3.07	No	No	0	4	6
13	R:R:D62	R:R:S65	4.42	No	No	0	7	5
14	R:R:F64	R:R:V68	2.62	No	No	0	2	4
15	R:R:L69	R:R:N139	8.24	No	No	0	4	5
16	R:R:L221	R:R:T70	2.95	No	No	0	3	7
17	R:R:T75	R:R:V76	4.76	No	No	0	5	4
18	R:R:F77	R:R:V81	2.62	No	No	0	4	6
19	R:R:L78	R:R:Y82	2.34	Yes	No	0	5	7
20	R:R:H135	R:R:L78	3.86	No	Yes	0	5	5
21	R:R:I327	R:R:L78	4.28	No	Yes	0	4	5
22	R:R:I132	R:R:P79	3.39	No	No	0	7	5
23	R:R:F128	R:R:Y82	6.19	No	No	0	8	7
24	R:R:T334	R:R:Y82	2.5	No	No	0	7	7
25	R:R:T334	R:R:V85	4.76	No	No	0	7	8
26	R:R:C338	R:R:V85	5.12	No	No	0	7	8
27	R:R:F86	R:R:L90	15.83	Yes	No	5	6	6
28	R:R:F86	R:R:V125	5.24	Yes	No	5	6	6
29	R:R:F86	R:R:P129	7.22	Yes	No	0	6	8
30	R:R:C338	R:R:V88	6.83	No	No	0	7	6
31	R:R:L90	R:R:P91	3.28	No	No	0	6	5
32	R:R:L90	R:R:V125	8.94	No	No	5	6	6
33	R:R:A118	R:R:N93	3.13	No	No	0	8	9
34	R:R:D121	R:R:N93	13.46	Yes	No	0	9	9
35	R:R:N93	R:R:P341	6.52	No	No	0	9	9
36	R:R:G94	R:R:L122	3.42	No	No	0	4	8
37	R:R:M95	R:R:W98	3.49	No	Yes	0	6	3
38	R:R:A96	R:R:Y345	2.67	No	Yes	0	9	7
39	R:R:A118	R:R:L97	3.15	No	No	0	8	7
40	R:R:L119	R:R:L97	5.54	No	No	0	6	7
41	R:R:L122	R:R:L97	2.77	No	No	0	8	7
42	R:R:F102	R:R:W98	10.02	No	Yes	0	4	3
43	R:R:R103	R:R:W98	10	No	Yes	6	5	3
44	R:R:A358	R:R:W98	2.59	No	Yes	6	5	3
45	R:R:F351	R:R:V99	6.55	Yes	No	0	8	8
46	R:R:F100	R:R:V111	10.49	Yes	No	0	6	7
47	R:R:F100	R:R:M114	9.95	Yes	Yes	2	6	8
48	R:R:A115	R:R:F100	4.16	No	Yes	0	7	6
49	R:R:F100	R:R:Y345	8.25	Yes	Yes	2	6	7
50	R:R:F100	R:R:F351	11.79	Yes	Yes	2	6	8
51	R:R:F102	R:R:L101	2.44	No	No	0	4	4
52	R:R:A358	R:R:R103	4.15	No	No	6	5	5
53	R:R:T104	R:R:V111	11.11	No	No	0	6	7
54	R:R:H108	R:R:K106	10.48	No	No	0	7	7
55	R:R:A188	R:R:K107	3.21	No	No	0	3	6
56	R:R:P109	R:R:Y113	2.78	Yes	Yes	1	7	7
57	R:R:P109	R:R:Q172	4.74	Yes	No	1	7	8
58	R:R:K187	R:R:P109	6.69	No	Yes	0	6	7
59	R:R:A191	R:R:I112	4.87	No	No	0	8	6
60	R:R:I112	R:R:I192	2.94	No	No	0	6	3
61	R:R:C168	R:R:Y113	5.38	No	Yes	1	7	7
62	R:R:Q172	R:R:Y113	6.76	No	Yes	1	8	7
63	R:R:A191	R:R:Y113	4	No	Yes	0	8	7
64	R:R:L169	R:R:M114	5.65	No	Yes	0	8	8
65	R:R:M114	R:R:Y345	11.97	Yes	Yes	2	8	7
66	R:R:F165	R:R:N116	13.29	Yes	No	1	7	9
67	R:R:N116	R:R:S195	5.96	No	No	1	9	7
68	R:R:D121	R:R:L117	2.71	Yes	No	2	9	9
69	R:R:L117	R:R:S162	3	No	No	2	9	9
70	R:R:L117	R:R:Y345	3.52	No	Yes	2	9	7
71	R:R:L119	R:R:L123	4.15	No	No	0	6	7
72	R:R:L119	R:R:W199	5.69	No	No	0	6	9
73	R:R:A120	R:R:C161	3.61	No	Yes	0	8	7
74	R:R:D121	R:R:S162	5.89	Yes	No	2	9	9
75	R:R:D121	R:R:S337	4.42	Yes	No	0	9	9
76	R:R:L123	R:R:N158	4.12	No	No	0	7	8
77	R:R:N158	R:R:S124	5.96	No	No	0	8	7
78	R:R:S337	R:R:V125	3.23	No	No	0	9	6
79	R:R:I126	R:R:W127	12.92	No	No	0	5	7
80	R:R:V150	R:R:W127	6.13	No	No	7	5	7
81	R:R:F154	R:R:W127	19.04	No	No	7	5	7
82	R:R:F128	R:R:F155	6.43	No	No	0	8	6
83	R:R:L130	R:R:Y143	7.03	No	Yes	0	7	7
84	R:R:H135	R:R:K131	10.48	No	No	0	5	7
85	R:R:K131	R:R:L151	2.82	No	No	0	7	5
86	R:R:H135	R:R:Y134	6.53	No	Yes	0	5	5
87	R:R:N139	R:R:Y134	11.63	No	Yes	0	5	5
88	R:R:W141	R:R:Y134	9.65	Yes	Yes	0	9	5
89	R:R:T225	R:R:Y134	2.5	No	Yes	0	4	5
90	R:R:D228	R:R:Y134	6.9	No	Yes	0	4	5
91	R:R:I223	R:R:N140	15.58	No	No	0	3	4
92	R:R:W141	R:R:Y143	11.58	Yes	Yes	0	9	7
93	R:R:C148	R:R:W141	2.61	No	Yes	8	9	9
94	R:R:C226	R:R:W141	2.61	No	Yes	8	9	9
95	R:R:I142	R:R:Y143	14.51	No	Yes	0	1	7
96	R:R:E145	R:R:N149	17.09	No	No	0	3	6
97	R:R:E145	R:R:K213	2.7	No	No	0	3	5
98	R:R:C148	R:R:C226	7.28	No	No	8	9	9
99	R:R:N149	R:R:Y210	4.65	No	No	0	6	5
100	R:R:N149	R:R:Q214	2.64	No	No	0	6	4
101	R:R:F154	R:R:V150	3.93	No	No	7	5	5
102	R:R:I152	R:R:L209	5.71	No	No	0	5	4
103	R:R:H227	R:R:I152	14.58	No	No	0	5	5
104	R:R:G153	R:R:L209	3.42	No	No	0	6	4
105	R:R:G153	R:R:Y210	4.35	No	No	0	6	5
106	R:R:F154	R:R:N158	2.42	No	No	0	5	8
107	R:R:F155	R:R:Y156	3.09	No	No	0	6	5
108	R:R:F155	R:R:L330	2.44	No	No	0	6	5
109	R:R:Y156	R:R:Y160	2.98	No	No	0	5	7
110	R:R:F243	R:R:Y156	8.25	Yes	No	0	6	5
111	R:R:M159	R:R:S333	3.07	No	No	0	7	8
112	R:R:I163	R:R:Y160	2.42	No	No	0	7	7
113	R:R:L246	R:R:Y160	4.69	No	No	0	5	7
114	R:R:C161	R:R:F165	4.19	Yes	Yes	1	7	7
115	R:R:C161	R:R:W199	6.53	Yes	No	1	7	9
116	R:R:C161	R:R:I202	3.27	Yes	Yes	1	7	8
117	R:R:F251	R:R:I163	3.77	Yes	No	0	8	7
118	R:R:I163	R:R:Y296	6.04	No	Yes	0	7	9
119	R:R:I198	R:R:L164	4.28	Yes	No	1	7	6
120	R:R:I202	R:R:L164	2.85	Yes	No	1	8	6
121	R:R:L164	R:R:V250	2.98	No	No	0	6	5
122	R:R:F165	R:R:S195	5.28	Yes	No	1	7	7
123	R:R:F165	R:R:W199	4.01	Yes	No	1	7	9
124	R:R:M166	R:R:Y296	4.79	No	Yes	0	8	9
125	R:R:D340	R:R:M166	4.16	No	No	0	9	8
126	R:R:M166	R:R:Y344	7.18	No	No	0	8	9
127	R:R:P254	R:R:T167	6.99	No	No	0	9	7
128	R:R:T167	R:R:T258	4.71	No	No	0	7	8
129	R:R:L169	R:R:Y344	2.34	No	No	0	8	9
130	R:R:S170	R:R:T258	7.99	No	No	3	9	8
131	R:R:S170	R:R:Y262	13.99	No	Yes	3	9	9
132	R:R:R173	R:R:Y262	6.17	No	Yes	3	9	9
133	R:R:M265	R:R:R173	2.48	No	No	3	8	9
134	R:R:V178	R:R:Y174	16.4	No	No	0	7	8
135	R:R:L264	R:R:Y174	2.34	No	No	0	4	8
136	R:R:I177	R:R:M268	2.92	No	No	0	8	5
137	R:R:M268	R:R:V178	4.56	No	No	0	5	7
138	R:R:N179	R:R:P180	6.52	No	No	0	6	8
139	R:R:K186	R:R:N189	5.6	No	No	0	7	4
140	R:R:I190	R:R:K186	10.18	No	No	0	4	7
141	R:R:I194	R:R:I198	2.94	No	Yes	1	5	7
142	R:R:I198	R:R:I202	2.94	Yes	Yes	1	7	8
143	R:R:I207	R:R:P208	3.39	No	No	0	4	7
144	R:R:L209	R:R:Y242	11.72	No	Yes	0	4	5
145	R:R:Q214	R:R:V212	2.87	No	No	0	4	4
146	R:R:L234	R:R:V212	4.47	No	No	0	5	4
147	R:R:K213	R:R:T215	6.01	No	No	0	5	4
148	R:R:H227	R:R:Q214	3.71	No	No	0	5	4
149	R:R:I216	R:R:P231	5.08	No	No	4	1	4
150	R:R:F217	R:R:P219	7.22	No	No	0	1	1
151	R:R:F217	R:R:N222	2.42	No	No	0	1	5
152	R:R:F217	R:R:T224	6.49	No	No	0	1	5
153	R:R:I218	R:R:P219	3.39	No	No	0	4	1
154	R:R:I218	R:R:V229	4.61	No	No	0	4	4
155	R:R:I223	R:R:L221	5.71	No	No	0	3	3
156	R:R:T225	R:R:V229	4.76	No	No	0	4	4
157	R:R:D228	R:R:Y323	5.75	No	Yes	0	4	4
158	R:R:L230	R:R:P231	4.93	No	No	0	5	4
159	R:R:L230	R:R:L234	2.77	No	No	0	5	5
160	R:R:L230	R:R:L235	2.77	No	No	0	5	4
161	R:R:L234	R:R:M239	5.65	No	No	0	5	4
162	R:R:I314	R:R:L235	4.28	No	No	0	2	4
163	R:R:K315	R:R:V236	7.59	No	No	0	2	3
164	R:R:M239	R:R:Y242	3.59	No	Yes	9	4	5
165	R:R:F243	R:R:M239	3.73	Yes	No	9	6	4
166	R:R:F240	R:R:L244	3.65	No	No	0	3	5
167	R:R:F240	R:R:Y311	4.13	No	No	0	3	5
168	R:R:F240	R:R:K315	9.93	No	No	0	3	2
169	R:R:F243	R:R:Y242	4.13	Yes	Yes	9	6	5
170	R:R:L246	R:R:Y242	8.21	No	Yes	0	5	5
171	R:R:F243	R:R:Y311	9.28	Yes	No	0	6	5
172	R:R:I248	R:R:L252	4.28	No	No	0	4	4
173	R:R:F253	R:R:G249	3.01	No	No	0	6	5
174	R:R:F251	R:R:L252	3.65	Yes	No	0	8	4
175	R:R:F251	R:R:F300	3.22	Yes	No	0	8	9
176	R:R:F251	R:R:T301	6.49	Yes	Yes	0	8	5
177	R:R:F251	R:R:N304	12.08	Yes	No	0	8	8
178	R:R:F253	R:R:P254	2.89	No	No	0	6	9
179	R:R:A255	R:R:Y296	2.67	No	Yes	0	7	9
180	R:R:T258	R:R:Y262	2.5	No	Yes	3	8	9
181	R:R:L264	R:R:S260	3	No	No	0	4	4
182	R:R:M265	R:R:Y262	2.39	No	Yes	3	8	9
183	R:R:I289	R:R:Y262	6.04	No	Yes	0	8	9
184	R:R:L293	R:R:Y262	3.52	No	Yes	0	8	9
185	R:R:R267	R:R:V263	2.62	No	No	0	4	3
186	R:R:L264	R:R:R267	2.43	No	No	0	4	4
187	R:R:I266	R:R:I286	4.42	No	No	0	5	6
188	R:R:I266	R:R:I289	5.89	No	No	0	5	8
189	R:R:I286	R:R:R270	2.51	No	No	0	6	4
190	R:R:M274	R:R:R282	11.17	No	No	0	4	6
191	R:R:D275	R:R:N277	10.77	No	No	0	4	4
192	R:R:R282	R:R:S278	5.27	No	No	0	6	4
193	R:R:E279	R:R:K283	8.1	No	No	0	3	5
194	R:R:H349	R:R:R284	5.64	No	No	0	5	7
195	R:R:L288	R:R:V347	4.47	No	No	0	8	7
196	R:R:T291	R:R:V343	3.17	No	No	0	5	8
197	R:R:V292	R:R:Y344	5.05	No	No	0	8	9
198	R:R:L293	R:R:L297	2.77	No	No	0	8	5
199	R:R:I339	R:R:M295	7.29	No	No	0	6	6
200	R:R:L297	R:R:Y296	3.52	No	Yes	0	5	9
201	R:R:L297	R:R:T301	2.95	No	Yes	0	5	5
202	R:R:C299	R:R:N336	9.45	No	No	0	9	9
203	R:R:F300	R:R:N336	12.08	No	No	0	9	9
204	R:R:P302	R:R:T301	3.5	No	Yes	0	9	5
205	R:R:L305	R:R:T301	2.95	No	Yes	0	6	5
206	R:R:N304	R:R:S303	2.98	No	No	0	8	7
207	R:R:S303	R:R:S333	4.89	No	No	0	7	8
208	R:R:L306	R:R:L325	4.15	No	No	0	4	5
209	R:R:L307	R:R:Y326	8.21	No	No	0	5	4
210	R:R:H310	R:R:Y311	5.44	Yes	No	0	4	5
211	R:R:H310	R:R:I314	2.65	Yes	No	0	4	2
212	R:R:H310	R:R:S320	5.58	Yes	No	0	4	2
213	R:R:H310	R:R:V322	5.54	Yes	No	0	4	4
214	R:R:H321	R:R:L313	2.57	No	No	0	4	1
215	R:R:Q317	R:R:S316	7.22	No	No	0	1	1
216	R:R:H321	R:R:Q319	2.47	No	No	0	4	4
217	R:R:H321	R:R:V322	2.77	No	No	0	4	4
218	R:R:I327	R:R:Y323	8.46	No	Yes	0	4	4
219	R:R:L330	R:R:Y326	8.21	No	No	0	5	4
220	R:R:L330	R:R:S333	4.5	No	No	0	5	8
221	R:R:D340	R:R:N336	5.39	No	No	0	9	9
222	R:R:P341	R:R:Y345	5.56	No	Yes	0	9	7
223	R:R:F342	R:R:F346	5.36	No	No	0	6	7
224	R:R:F351	R:R:Y345	3.09	Yes	Yes	2	8	7
225	R:R:D350	R:R:S348	2.94	No	No	0	6	8
226	R:R:F351	R:R:S348	2.64	Yes	No	0	8	8
227	R:R:D353	R:R:H354	11.35	No	No	0	4	5
228	R:R:K187	R:R:W175	2.32	No	No	0	6	5
229	R:R:L147	R:R:W141	2.28	No	Yes	0	6	9
230	R:R:H137	R:R:Y143	2.18	No	Yes	0	4	7
231	R:R:F346	R:R:F351	2.14	No	Yes	0	7	8
232	R:R:C338	R:R:G89	1.96	No	No	0	7	8
233	R:R:A188	R:R:P109	1.87	No	Yes	0	3	7
234	R:R:G157	R:R:T206	1.82	No	No	0	5	7
235	R:R:G157	R:R:I202	1.76	No	Yes	0	5	8
236	R:R:G193	R:R:I192	1.76	No	No	0	2	3
237	R:R:C331	R:R:V81	1.71	No	No	0	6	6
238	R:R:A261	R:R:S170	1.71	No	No	0	7	9
239	R:R:A273	R:R:S271	1.71	No	No	0	4	4
240	R:R:A355	R:R:V99	1.7	No	No	0	7	8
241	R:R:G138	R:R:N139	1.7	No	No	0	4	5
242	R:R:A247	R:R:V308	1.7	No	No	0	5	6
243	R:R:L78	R:R:P79	1.64	Yes	No	0	5	5
244	R:R:C168	R:R:I194	1.64	No	No	1	7	5
245	R:R:C168	R:R:I198	1.64	No	Yes	1	7	7
246	R:R:L332	R:R:P302	1.64	No	No	0	8	9
247	R:R:G318	R:R:Q317	1.64	No	No	0	1	1
248	R:R:C299	R:R:M295	1.62	No	No	0	9	6
249	R:R:A110	R:R:M114	1.61	No	Yes	0	8	8
250	R:R:V211	R:R:V212	1.6	No	No	0	3	4
251	R:R:V292	R:R:V343	1.6	No	No	0	8	8
252	R:R:T57	R:R:V42	1.59	No	No	0	3	5
253	R:R:T74	R:R:V68	1.59	Yes	No	0	4	4
254	R:R:C331	R:R:L78	1.59	No	Yes	0	6	5
255	R:R:T83	R:R:V87	1.59	No	No	0	5	5
256	R:R:A324	R:R:L73	1.58	No	No	0	1	3
257	R:R:A247	R:R:L307	1.58	No	No	0	5	5
258	R:R:A285	R:R:L269	1.58	No	No	0	7	8
259	R:R:A329	R:R:L306	1.58	No	No	0	7	4
260	R:R:T74	R:R:T75	1.57	Yes	No	0	4	5
261	R:R:A358	R:R:N357	1.56	No	No	0	5	4
262	R:R:I84	R:R:V88	1.54	No	No	0	5	6
263	R:R:I207	R:R:V211	1.54	No	No	0	4	3
264	R:R:I266	R:R:V290	1.54	No	No	0	5	5
265	R:R:H108	R:R:P109	1.53	No	Yes	0	7	7
266	R:R:M274	R:R:S271	1.53	No	No	0	4	4
267	R:R:K72	R:R:V76	1.52	No	No	0	2	4
268	R:R:I327	R:R:T74	1.52	No	Yes	0	4	4
269	R:R:M95	R:R:V99	1.52	No	No	0	6	8
270	R:R:I223	R:R:T225	1.52	No	No	0	3	4
271	R:R:L335	R:R:V85	1.49	No	No	0	5	8
272	R:R:N241	R:R:S245	1.49	No	No	0	3	3
273	R:R:L325	R:R:V322	1.49	No	No	0	5	4
274	R:R:N179	R:R:V178	1.48	No	No	0	6	7
275	R:R:I314	R:R:I39	1.47	No	No	0	2	7
276	R:R:L73	R:R:T74	1.47	No	Yes	0	3	4
277	R:R:I80	R:R:I84	1.47	No	No	0	5	5
278	R:R:L257	R:R:T167	1.47	No	No	0	7	7
279	R:R:I190	R:R:I194	1.47	No	No	0	4	5
280	R:R:L288	R:R:T291	1.47	No	No	0	8	5
281	R:R:K105	R:R:K106	1.44	No	No	0	6	7
282	R:R:Q172	R:R:V176	1.43	No	No	0	8	8
283	R:R:I192	R:R:L196	1.43	No	No	0	3	5
284	R:R:I286	R:R:L269	1.43	No	No	0	6	8
285	R:R:G144	R:R:W141	1.41	No	Yes	0	8	9
286	R:R:A133	R:R:Y143	1.33	No	Yes	0	4	7
287	R:R:A261	R:R:Y174	1.33	No	No	0	7	8
288	R:R:D350	R:R:D353	1.33	No	No	0	6	4
289	R:R:F86	R:R:V87	1.31	Yes	No	0	6	5
290	R:R:D62	R:R:E63	1.3	No	No	0	7	5
291	R:R:K356	R:R:R352	1.24	No	No	0	4	8
292	R:R:L269	R:R:R282	1.21	No	No	0	8	6
293	R:R:L288	R:R:R284	1.21	No	No	0	8	7
294	R:R:N241	R:R:Y242	1.16	No	Yes	0	3	5
295	R:R:H349	R:R:R352	1.13	No	No	0	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T74	1.5375	4	0	4
2	R:R:L78	2.742	5	0	5
3	R:R:F86	7.4	4	5	6
4	R:R:W98	6.525	4	6	3
5	R:R:F100	8.928	5	2	6
6	R:R:P109	3.522	5	1	7
7	R:R:Y113	4.73	4	1	7
8	R:R:M114	7.295	4	2	8
9	R:R:D121	6.62	4	2	9
10	R:R:Y134	7.442	5	0	5
11	R:R:W141	5.02333	6	8	9
12	R:R:Y143	7.326	5	0	7
13	R:R:C161	4.4	4	1	7
14	R:R:F165	6.6925	4	1	7
15	R:R:I198	2.95	4	1	7
16	R:R:I202	2.705	4	1	8
17	R:R:Y242	5.762	5	9	5
18	R:R:F243	6.3475	4	9	6
19	R:R:F251	5.842	5	0	8
20	R:R:Y262	5.76833	6	3	9
21	R:R:Y296	4.255	4	0	9
22	R:R:T301	3.9725	4	0	5
23	R:R:H310	4.4	5	0	4
24	R:R:Y323	4.7725	4	0	4
25	R:R:Y345	5.84333	6	2	7
26	R:R:F351	5.242	5	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H310	R:R:S320	12.3245	5.58	Yes	No	0	4	2
2	R:R:L38	R:R:S320	11.5045	3	No	No	0	8	2
3	R:R:L38	R:R:S65	11.4514	7.51	No	No	0	8	5
4	R:R:H310	R:R:I314	10.4433	2.65	Yes	No	0	4	2
5	R:R:I327	R:R:T74	11.7698	1.52	No	Yes	0	4	4
6	R:R:S37	R:R:Y323	12.4114	2.54	No	Yes	0	8	4
7	R:R:H310	R:R:S37	13.1783	2.79	Yes	No	0	4	8
8	R:R:I327	R:R:L78	11.8325	4.28	No	Yes	0	4	5
9	R:R:L78	R:R:Y82	36.5974	2.34	Yes	No	0	5	7
10	R:R:H135	R:R:L78	23.6023	3.86	No	Yes	0	5	5
11	R:R:H135	R:R:Y134	20.766	6.53	No	Yes	0	5	5
12	R:R:F128	R:R:F155	43.5821	6.43	No	No	0	8	6
13	R:R:F155	R:R:Y156	47.5423	3.09	No	No	0	6	5
14	R:R:F243	R:R:Y156	41.4886	8.25	Yes	No	0	6	5
15	R:R:F243	R:R:Y311	33.8141	9.28	Yes	No	0	6	5
16	R:R:H310	R:R:Y311	30.4616	5.44	Yes	No	0	4	5
17	R:R:T334	R:R:Y82	10.6459	2.5	No	No	0	7	7
18	R:R:D121	R:R:S337	10.4144	4.42	Yes	No	0	9	9
19	R:R:L117	R:R:Y345	11.6637	3.52	No	Yes	2	9	7
20	R:R:M114	R:R:Y345	72.4229	11.97	Yes	Yes	2	8	7
21	R:R:L169	R:R:M114	92.3496	5.65	No	Yes	0	8	8
22	R:R:L169	R:R:Y344	92.832	2.34	No	No	0	8	9
23	R:R:M166	R:R:Y344	96.9418	7.18	No	No	0	8	9
24	R:R:M166	R:R:Y296	95.6731	4.79	No	Yes	0	8	9
25	R:R:I163	R:R:Y296	96.2761	6.04	No	Yes	0	7	9
26	R:R:I163	R:R:Y160	100	2.42	No	No	0	7	7
27	R:R:Y156	R:R:Y160	78.9783	2.98	No	No	0	5	7
28	R:R:A118	R:R:N93	50.4896	3.13	No	No	0	8	9
29	R:R:N93	R:R:P341	48.9991	6.52	No	No	0	9	9
30	R:R:P341	R:R:Y345	49.7998	5.56	No	Yes	0	9	7
31	R:R:A118	R:R:L97	49.5779	3.15	No	No	0	8	7
32	R:R:F100	R:R:M114	18.9571	9.95	Yes	Yes	2	6	8
33	R:R:F100	R:R:F351	15.5082	11.79	Yes	Yes	2	6	8
34	R:R:F351	R:R:V99	20.1968	6.55	Yes	No	0	8	8
35	R:R:M95	R:R:V99	15.8314	1.52	No	No	0	6	8
36	R:R:F351	R:R:Y345	19.8399	3.09	Yes	Yes	2	8	7
37	R:R:M95	R:R:W98	13.598	3.49	No	Yes	0	6	3
38	R:R:L119	R:R:L97	46.785	5.54	No	No	0	6	7
39	R:R:P109	R:R:Y113	10.2841	2.78	Yes	Yes	1	7	7
40	R:R:C168	R:R:Y113	20.163	5.38	No	Yes	1	7	7
41	R:R:C168	R:R:I198	21.012	1.64	No	Yes	1	7	7
42	R:R:I198	R:R:I202	26.8969	2.94	Yes	Yes	1	7	8
43	R:R:C161	R:R:I202	32.6323	3.27	Yes	Yes	1	7	8
44	R:R:C161	R:R:W199	34.3544	6.53	Yes	No	1	7	9
45	R:R:L119	R:R:W199	38.9079	5.69	No	No	0	6	9
46	R:R:W141	R:R:Y134	14.1286	9.65	Yes	Yes	0	9	5
47	R:R:L209	R:R:Y242	11.9435	11.72	No	Yes	0	4	5
48	R:R:L234	R:R:V212	14.6737	4.47	No	No	0	5	4
49	R:R:L234	R:R:M239	24.2005	5.65	No	No	0	5	4
50	R:R:F243	R:R:M239	15.5371	3.73	Yes	No	9	6	4
51	R:R:L230	R:R:L234	13.4822	2.77	No	No	0	5	5
52	R:R:L246	R:R:Y242	20.8046	8.21	No	Yes	0	5	5
53	R:R:F251	R:R:I163	11.4707	3.77	Yes	No	0	8	7
54	R:R:L297	R:R:Y296	43.5965	3.52	No	Yes	0	5	9
55	R:R:L293	R:R:L297	43.8329	2.77	No	No	0	8	5
56	R:R:L293	R:R:Y262	42.6849	3.52	No	Yes	0	8	9
57	R:R:S170	R:R:Y262	16.4295	13.99	No	Yes	3	9	9
58	R:R:A261	R:R:S170	15.4262	1.71	No	No	0	7	9
59	R:R:A261	R:R:Y174	14.0659	1.33	No	No	0	7	8
60	R:R:I289	R:R:Y262	16.7334	6.04	No	Yes	0	8	9
61	R:R:I266	R:R:I289	15.3731	5.89	No	No	0	5	8
62	R:R:I266	R:R:I286	12.6333	4.42	No	No	0	5	6
63	R:R:V292	R:R:Y344	12.2522	5.05	No	No	0	8	9
64	R:R:V292	R:R:V343	10.9498	1.6	No	No	0	8	8
65	R:R:F128	R:R:Y82	42.8055	6.19	No	No	0	8	7
66	R:R:M239	R:R:Y242	10.6121	3.59	No	Yes	9	4	5
67	R:R:L246	R:R:Y160	21.3883	4.69	No	No	0	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8ZME_nogp

PDB Summary
PDB	8ZME_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.34
Number of Linked Nodes	272
Number of Links	295
Number of Hubs	26
Number of Links mediated by Hubs	106
Number of Communities	9
Number of Nodes involved in Communities	43
Number of Links involved in Communities	50

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	41049
Length Of Smallest Path	3
Average Path Length	15.2773
Length of Longest Path	35
Minimum Path Strength	1.185
Average Path Strength	4.91057
Maximum Path Strength	15.98
Minimum Path Correlation	0.7
Average Path Correlation	0.928161
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	47.3311
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	26.5818
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • G-protein alpha-subunit binding • molecular transducer activity • signaling receptor activity • signaling receptor binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • enzyme binding • protease binding • peptide receptor activity • thrombin-activated receptor activity • proteinase-activated receptor activity • G protein-coupled peptide receptor activity • G-protein beta-subunit binding • multicellular organismal process • regulation of body fluid levels • wound healing • response to stimulus • hemostasis • biological regulation • blood coagulation • response to stress • coagulation • regulation of biological quality • response to wounding • developmental process • myeloid leukocyte differentiation • cellular developmental process
Gene Ontology	Biological Process	• multicellular organismal process • regulation of body fluid levels • wound healing • response to stimulus • hemostasis • biological regulation • blood coagulation • response to stress • coagulation • regulation of biological quality • response to wounding • developmental process • myeloid leukocyte differentiation • cellular developmental process • hemopoiesis • cell development • mononuclear cell differentiation • myeloid cell differentiation • cell differentiation • anatomical structure development • dendritic cell differentiation • cellular process • mature conventional dendritic cell differentiation • leukocyte differentiation • regulation of biological process • regulation of cellular process • reactive oxygen species metabolic process • positive regulation of biological process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • positive regulation of cellular process • cellular response to stimulus • regulation of signaling • signaling • regulation of JNK cascade • regulation of signal transduction • regulation of MAPK cascade • intracellular signal transduction • cell communication • regulation of intracellular signal transduction • regulation of response to stimulus • JNK cascade • intracellular signaling cassette • MAPK cascade • regulation of cell communication • signal transduction • regulation of cellular component organization • positive regulation of cellular component organization • cell projection organization • plasma membrane bounded cell projection assembly • cellular component biogenesis • cellular component organization • pseudopodium assembly • cellular component assembly • positive regulation of cell projection organization • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • positive regulation of cellular component biogenesis • regulation of cell projection organization • regulation of cell projection assembly • regulation of cellular component biogenesis • regulation of plasma membrane bounded cell projection assembly • positive regulation of pseudopodium assembly • regulation of pseudopodium assembly • cell projection assembly • regulation of plasma membrane bounded cell projection organization • positive regulation of plasma membrane bounded cell projection assembly • pseudopodium organization • chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • response to external stimulus • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • taxis • response to chemical • regulation of locomotion • locomotion • biological process involved in interspecies interaction between organisms • immune response • response to other organism • defense response • defense response to symbiont • response to biotic stimulus • immune system process • defense response to other organism • innate immune response • response to external biotic stimulus • positive regulation of cell communication • positive regulation of response to biotic stimulus • positive regulation of signal transduction • pattern recognition receptor signaling pathway • immune response-activating signaling pathway • positive regulation of toll-like receptor 3 signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • innate immune response-activating signaling pathway • positive regulation of pattern recognition receptor signaling pathway • regulation of innate immune response • positive regulation of intracellular signal transduction • regulation of pattern recognition receptor signaling pathway • positive regulation of defense response • regulation of immune response • activation of innate immune response • activation of immune response • regulation of defense response • cytoplasmic pattern recognition receptor signaling pathway • regulation of response to biotic stimulus • intracellular receptor signaling pathway • regulation of cytoplasmic pattern recognition receptor signaling pathway • endolysosomal toll-like receptor signaling pathway • immune response-regulating signaling pathway • regulation of response to stress • regulation of toll-like receptor 3 signaling pathway • positive regulation of innate immune response • toll-like receptor 3 signaling pathway • positive regulation of signaling • regulation of biosynthetic process • chemokine (C-X-C motif) ligand 2 production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of chemokine production • regulation of gene expression • regulation of chemokine (C-X-C motif) ligand 2 production • biosynthetic process • regulation of cytokine production • cytokine production • chemokine production • regulation of macromolecule biosynthetic process • regulation of multicellular organismal process • macromolecule metabolic process • negative regulation of biological process • negative regulation of chemokine production • negative regulation of cellular process • negative regulation of macromolecule metabolic process • negative regulation of metabolic process • negative regulation of cytokine production • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of multicellular organismal process • interleukin-1 production • regulation of interleukin-1 beta production • positive regulation of macromolecule biosynthetic process • positive regulation of interleukin-1 beta production • positive regulation of biosynthetic process • positive regulation of interleukin-1 production • positive regulation of macromolecule metabolic process • regulation of interleukin-1 production • interleukin-1 beta production • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of cytokine production • positive regulation of interleukin-8 production • interleukin-8 production • regulation of interleukin-8 production • positive regulation of JNK cascade • positive regulation of MAPK cascade • positive regulation of chemokine production • system process • renal system process • regulation of renal system process • regulation of blood pressure • regulation of system process • regulation of glomerular filtration • positive regulation of glomerular filtration • regulation of systemic arterial blood pressure • circulatory system process • renal system process involved in regulation of blood volume • renal system process involved in regulation of systemic arterial blood pressure • glomerular filtration • blood circulation • renal filtration • negative regulation of signaling • negative regulation of cytoplasmic pattern recognition receptor signaling pathway • negative regulation of intracellular signal transduction • negative regulation of cell communication • negative regulation of toll-like receptor 3 signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of immune system process • interleukin-10 production • regulation of interleukin-10 production • positive regulation of interleukin-10 production • regulation of systemic arterial blood pressure by renin-angiotensin • regulation of localization • regulation of systemic arterial blood pressure by hormone • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure • intracellular protein localization • establishment of protein localization to extracellular region • regulation of systemic arterial blood pressure by circulatory renin-angiotensin • protein secretion • establishment of localization • positive regulation of renin secretion into blood stream • regulation of protein secretion • regulation of secretion • positive regulation of protein localization • regulation of endocrine process • renin secretion into blood stream • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of protein localization • transport • positive regulation of secretion by cell • protein localization to extracellular region • positive regulation of protein transport • regulation of secretion by cell • secretion by cell • regulation of renin secretion into blood stream • positive regulation of secretion • signal release • regulation of transport • secretion • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • endocrine process • positive regulation of transport • protein transport • macromolecule localization • cell activation • lymphocyte activation • cell activation involved in immune response • leukocyte activation • immune effector process • T cell activation involved in immune response • T cell activation • leukocyte activation involved in immune response • lymphocyte activation involved in immune response • regulation of immune effector process • regulation of myeloid leukocyte mediated immunity • regulated exocytosis • positive regulation of leukocyte mediated immunity • leukocyte degranulation • myeloid leukocyte mediated immunity • vesicle-mediated transport • myeloid leukocyte activation • positive regulation of leukocyte degranulation • positive regulation of regulated secretory pathway • establishment of localization in cell • leukocyte mediated immunity • regulation of leukocyte mediated immunity • exocytosis • positive regulation of myeloid leukocyte mediated immunity • eosinophil mediated immunity • cellular localization • eosinophil activation • positive regulation of exocytosis • regulation of regulated secretory pathway • regulation of eosinophil degranulation • positive regulation of eosinophil degranulation • eosinophil degranulation • positive regulation of immune effector process • eosinophil activation involved in immune response • regulation of leukocyte degranulation • regulation of vesicle-mediated transport • myeloid cell activation involved in immune response • regulation of exocytosis • granulocyte activation • defense response to virus • response to virus • positive regulation of DNA-templated transcription • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • regulation of cell motility • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • cell chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • positive regulation of leukocyte migration • leukocyte migration • cellular response to chemical stimulus • leukocyte chemotaxis • cell population proliferation • leukocyte proliferation • positive regulation of cytosolic calcium ion concentration • positive regulation of canonical NF-kappaB signal transduction • canonical NF-kappaB signal transduction • regulation of canonical NF-kappaB signal transduction • immune response-regulating cell surface receptor signaling pathway • cell surface toll-like receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • regulation of toll-like receptor 4 signaling pathway • positive regulation of toll-like receptor 4 signaling pathway • innate immune response activating cell surface receptor signaling pathway • cell surface pattern recognition receptor signaling pathway • cell surface receptor signaling pathway • toll-like receptor 4 signaling pathway • positive regulation of ERK1 and ERK2 cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • import into cell • positive regulation of membrane invagination • positive regulation of endocytosis • regulation of phagocytosis, engulfment • membrane invagination • phagocytosis • plasma membrane invagination • regulation of endocytosis • membrane organization • regulation of phagocytosis • phagocytosis, engulfment • positive regulation of phagocytosis • positive regulation of phagocytosis, engulfment • regulation of membrane invagination • endocytosis • positive regulation of organelle organization • regulation of cytoskeleton organization • regulation of actin filament-based process • regulation of cellular component size • protein-containing complex disassembly • positive regulation of actin filament depolymerization • regulation of protein-containing complex disassembly • actin filament depolymerization • regulation of actin filament depolymerization • actin filament-based process • positive regulation of protein-containing complex disassembly • cellular component disassembly • actin polymerization or depolymerization • regulation of actin filament organization • actin cytoskeleton organization • protein-containing complex organization • regulation of protein depolymerization • positive regulation of protein depolymerization • positive regulation of cytoskeleton organization • actin filament organization • regulation of actin polymerization or depolymerization • positive regulation of supramolecular fiber organization • regulation of organelle organization • organelle organization • regulation of actin filament length • regulation of actin cytoskeleton organization • regulation of supramolecular fiber organization • supramolecular fiber organization • protein depolymerization • cytoskeleton organization • regulation of anatomical structure size • interleukin-6 production • positive regulation of interleukin-6 production • regulation of interleukin-6 production • neutrophil-mediated killing of symbiont cell • regulation of killing of cells of another organism • disruption of cell in another organism • regulation of programmed cell death • positive regulation of neutrophil mediated cytotoxicity • positive regulation of leukocyte mediated cytotoxicity • response to bacterium • positive regulation of neutrophil mediated killing of symbiont cell • regulation of neutrophil mediated killing of gram-negative bacterium • biological process involved in interaction with symbiont • killing of cells of another organism • positive regulation of programmed cell death • leukocyte mediated cytotoxicity • cell death • positive regulation of neutrophil mediated killing of bacterium • regulation of cell killing • positive regulation of cell killing • disruption of anatomical structure in another organism • positive regulation of killing of cells of another organism • positive regulation of neutrophil mediated killing of gram-negative bacterium • defense response to Gram-negative bacterium • biological process involved in symbiotic interaction • regulation of neutrophil mediated killing of bacterium • defense response to bacterium • positive regulation of defense response to bacterium • neutrophil mediated immunity • modulation of process of another organism • regulation of biological process involved in symbiotic interaction • regulation of defense response to bacterium • neutrophil-mediated killing of bacterium • neutrophil mediated cytotoxicity • regulation of neutrophil mediated cytotoxicity • regulation of leukocyte mediated cytotoxicity • regulation of neutrophil mediated killing of symbiont cell • killing by host of symbiont cells • neutrophil-mediated killing of gram-negative bacterium • programmed cell death • cell killing • positive regulation of molecular function • regulation of molecular function • positive regulation of hydrolase activity • regulation of catalytic activity • regulation of hydrolase activity • positive regulation of catalytic activity • regulation of GTPase activity • positive regulation of GTPase activity • neutrophil activation • regulation of toll-like receptor 2 signaling pathway • positive regulation of toll-like receptor 2 signaling pathway • toll-like receptor 2 signaling pathway • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • positive regulation of small GTPase mediated signal transduction • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • negative regulation of establishment of protein localization • negative regulation of protein secretion • regulation of hormone secretion • regulation of peptide secretion • hormone secretion • negative regulation of peptide secretion • peptide secretion • amide transport • negative regulation of protein localization • regulation of peptide transport • peptide transport • negative regulation of insulin secretion • regulation of insulin secretion • peptide hormone secretion • hormone transport • insulin secretion • negative regulation of JNK cascade • negative regulation of MAPK cascade • regulation of tube diameter • regulation of tube size • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • positive chemotaxis • positive regulation of positive chemotaxis • regulation of positive chemotaxis • epithelium development • endothelial cell differentiation • endothelium development • tissue development • epithelial cell differentiation • endothelial cell development • epithelial cell development • establishment of endothelial barrier • cell junction maintenance • cell junction organization • cellular component maintenance • cell-cell junction maintenance • cell-cell junction organization • inflammatory response • G protein-coupled receptor signaling pathway • regulation of blood coagulation • regulation of coagulation • regulation of response to wounding • regulation of wound healing • regulation of hemostasis • cytokine production involved in immune response • production of molecular mediator of immune response • regulation of cytokine production involved in immune response • positive regulation of cytokine production involved in immune response • positive regulation of production of molecular mediator of immune response • regulation of production of molecular mediator of immune response • response to cytokine • cytokine-mediated signaling pathway • cellular response to tumor necrosis factor • tumor necrosis factor-mediated signaling pathway • cellular response to cytokine stimulus • regulation of tumor necrosis factor-mediated signaling pathway • regulation of cytokine-mediated signaling pathway • negative regulation of tumor necrosis factor-mediated signaling pathway • response to peptide • regulation of response to cytokine stimulus • negative regulation of response to cytokine stimulus • negative regulation of cytokine-mediated signaling pathway • response to tumor necrosis factor • regulation of type II interferon production • type II interferon production • positive regulation of type II interferon production • cell projection • cellular anatomical structure • pseudopodium • plasma membrane bounded cell projection • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • Golgi apparatus • organelle • cytoplasm • intracellular membrane-bounded organelle • endomembrane system • cell periphery • plasma membrane
Gene Ontology	Cellular Component	• cell projection • cellular anatomical structure • pseudopodium • plasma membrane bounded cell projection • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • Golgi apparatus • organelle • cytoplasm • intracellular membrane-bounded organelle • endomembrane system • cell periphery • plasma membrane • membrane • early endosome • endosome • intracellular vesicle • cytoplasmic vesicle • vesicle • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P55085
Sequence	>8ZME_nogp_Chain_R S L I G K V T V F S V D E F S A S V L T G K L T T V F L P I V Y T I V F V V G L P S N G M A L W V F L F R T K K K H P A V I Y M A N L A L A D L L S V I W F P L K I A Y H I H G N N W I Y G E A L C N V L I G F F Y G N M Y C S I L F M T C L S V Q R Y W V I V N P K K A N I A I G I S L A I W L L I L L V T I P L Y V V K Q T I F I P A L N I T T C H D V L P E Q L L V G D M F N Y F L S L A I G V F L F P A F L T A S A Y V L M I R M L R S S A M D E N S E K K R K R A I K L I V T V L A M Y L I C F T P S N L L L V V H Y F L I K S Q G Q S H V Y A L Y I V A L C L S T L N S C I D P F V Y Y F V S H D F R D H A K N A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5NDD	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	AZ8838; Na	-	2.8	2017-05-03	doi.org/10.1038/nature22309
	5NDZ	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	AZ3451; Na	-	3.6	2017-05-03	doi.org/10.1038/nature22309
	5NJ6	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-	-	4	2017-05-03	doi.org/10.1038/nature22309
	9D0A	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.1	2025-05-07	doi.org/10.1038/s41467-025-59138-x
	9D0A (No Gprot)	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-		3.1	2025-05-07	doi.org/10.1038/s41467-025-59138-x
	9E7R	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	GB88	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.18	2025-05-07	doi.org/10.1038/s41467-025-59138-x
	9E7R (No Gprot)	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	GB88	-		3.18	2025-05-07	doi.org/10.1038/s41467-025-59138-x
	8ZMD	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.25	2025-05-28	To be published
	8ZMD (No Gprot)	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-		3.25	2025-05-28	To be published
	8ZME	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.2	2025-05-28	To be published
	8ZME (No Gprot)	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-		3.2	2025-05-28	To be published

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Download 8ZME_nogp.zip

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