psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:S65	5.26	Yes	No	0	0	5
2	L:L:?1	R:R:V68	4.35	Yes	No	0	0	4
3	L:L:?1	R:R:H227	5.25	Yes	No	0	0	5
4	L:L:?1	R:R:V229	7.83	Yes	No	0	0	4
5	L:L:?1	R:R:E232	4.64	Yes	No	0	0	1
6	L:L:?1	R:R:L235	17.78	Yes	No	0	0	4
7	L:L:?1	R:R:H310	7.51	Yes	Yes	2	0	4
8	L:L:?1	R:R:Y311	4.79	Yes	Yes	2	0	5
9	L:L:?1	R:R:S320	16.65	Yes	No	0	0	2
10	L:L:?1	R:R:Y323	21.21	Yes	No	2	0	4
11	R:R:I218	R:R:V61	4.61	Yes	No	0	4	6
12	R:R:F64	R:R:V68	7.87	No	No	0	2	4
13	R:R:F64	R:R:H321	12.44	No	No	0	2	4
14	R:R:L69	R:R:N139	5.49	No	Yes	3	4	5
15	R:R:I223	R:R:L69	4.28	No	No	0	3	4
16	R:R:D228	R:R:L69	4.07	Yes	No	3	4	4
17	R:R:K72	R:R:V76	4.55	No	No	0	2	4
18	R:R:L73	R:R:V328	4.47	No	No	0	3	6
19	R:R:N139	R:R:T74	8.77	Yes	No	0	5	4
20	R:R:F77	R:R:L78	3.65	No	No	0	4	5
21	R:R:F77	R:R:V81	5.24	No	No	0	4	6
22	R:R:F77	R:R:V328	3.93	No	No	0	4	6
23	R:R:H135	R:R:L78	5.14	Yes	No	0	5	5
24	R:R:H135	R:R:P79	6.1	Yes	No	0	5	5
25	R:R:C331	R:R:V81	6.83	No	No	0	6	6
26	R:R:F128	R:R:Y82	12.38	Yes	Yes	5	8	7
27	R:R:K131	R:R:Y82	9.55	No	Yes	0	7	7
28	R:R:T334	R:R:Y82	7.49	No	Yes	5	7	7
29	R:R:F86	R:R:L90	7.31	No	No	0	6	6
30	R:R:F86	R:R:P129	14.45	No	No	0	6	8
31	R:R:L90	R:R:P91	4.93	No	No	0	6	5
32	R:R:L122	R:R:L90	4.15	No	No	0	8	6
33	R:R:P341	R:R:S92	8.91	No	No	0	9	7
34	R:R:F342	R:R:S92	3.96	No	No	0	6	7
35	R:R:D121	R:R:N93	5.39	Yes	No	0	9	9
36	R:R:N93	R:R:P341	13.03	No	No	0	9	9
37	R:R:M95	R:R:W98	9.31	No	No	0	6	3
38	R:R:A96	R:R:Y345	4	No	Yes	0	9	7
39	R:R:L119	R:R:L97	4.15	No	No	0	6	7
40	R:R:F102	R:R:W98	9.02	No	No	0	4	3
41	R:R:F351	R:R:V99	11.8	Yes	No	0	8	8
42	R:R:H354	R:R:V99	4.15	No	No	0	5	8
43	R:R:F100	R:R:V111	9.18	Yes	No	0	6	7
44	R:R:F100	R:R:M114	7.46	Yes	No	1	6	8
45	R:R:F100	R:R:Y345	11.35	Yes	Yes	1	6	7
46	R:R:F100	R:R:F351	11.79	Yes	Yes	1	6	8
47	R:R:K105	R:R:K106	11.49	No	No	0	6	7
48	R:R:H108	R:R:P109	10.68	No	No	0	7	7
49	R:R:A110	R:R:Q172	4.55	No	No	0	8	8
50	R:R:A191	R:R:I112	4.87	No	No	0	8	6
51	R:R:I112	R:R:I192	4.42	No	No	0	6	3
52	R:R:C168	R:R:Y113	10.75	No	Yes	0	7	7
53	R:R:Q172	R:R:Y113	11.27	No	Yes	0	8	7
54	R:R:A191	R:R:Y113	5.34	No	Yes	0	8	7
55	R:R:I194	R:R:Y113	6.04	No	Yes	0	5	7
56	R:R:L169	R:R:M114	5.65	No	No	0	8	8
57	R:R:M114	R:R:Y345	7.18	No	Yes	1	8	7
58	R:R:F165	R:R:N116	13.29	Yes	No	4	7	9
59	R:R:N116	R:R:S195	8.94	No	No	4	9	7
60	R:R:D121	R:R:L117	5.43	Yes	No	0	9	9
61	R:R:L117	R:R:M166	7.07	No	Yes	0	9	8
62	R:R:A118	R:R:Y345	4	No	Yes	0	8	7
63	R:R:L119	R:R:L123	6.92	No	No	0	6	7
64	R:R:L119	R:R:W199	6.83	No	No	0	6	9
65	R:R:D121	R:R:S162	8.83	Yes	No	0	9	9
66	R:R:D121	R:R:S337	4.42	Yes	No	0	9	9
67	R:R:D121	R:R:D340	6.65	Yes	Yes	0	9	9
68	R:R:L123	R:R:N158	8.24	No	No	0	7	8
69	R:R:N158	R:R:S124	5.96	No	No	0	8	7
70	R:R:F128	R:R:V125	7.87	Yes	No	0	8	6
71	R:R:I126	R:R:W127	9.4	No	Yes	0	5	7
72	R:R:L130	R:R:W127	5.69	No	Yes	0	7	7
73	R:R:V150	R:R:W127	4.9	No	Yes	0	5	7
74	R:R:F154	R:R:W127	12.03	No	Yes	0	5	7
75	R:R:F128	R:R:F155	5.36	Yes	Yes	0	8	6
76	R:R:F128	R:R:T334	5.19	Yes	No	5	8	7
77	R:R:L130	R:R:L147	5.54	No	No	0	7	6
78	R:R:H135	R:R:K131	3.93	Yes	No	0	5	7
79	R:R:F155	R:R:K131	3.72	Yes	No	0	6	7
80	R:R:A133	R:R:Y143	4	No	No	0	4	7
81	R:R:H135	R:R:Y134	10.89	Yes	Yes	3	5	5
82	R:R:N139	R:R:Y134	16.28	Yes	Yes	3	5	5
83	R:R:W141	R:R:Y134	7.72	Yes	Yes	0	9	5
84	R:R:C226	R:R:Y134	4.03	No	Yes	0	9	5
85	R:R:D228	R:R:Y134	10.34	Yes	Yes	3	4	5
86	R:R:H135	R:R:N139	10.2	Yes	Yes	3	5	5
87	R:R:H137	R:R:I136	6.63	No	No	0	4	4
88	R:R:D228	R:R:N139	5.39	Yes	Yes	3	4	5
89	R:R:N140	R:R:T224	4.39	No	No	0	4	5
90	R:R:W141	R:R:Y143	13.5	Yes	No	0	9	7
91	R:R:C148	R:R:W141	5.22	No	Yes	0	9	9
92	R:R:I142	R:R:Y143	8.46	No	No	0	1	7
93	R:R:E145	R:R:N149	6.57	No	No	0	3	6
94	R:R:E145	R:R:K213	8.1	No	No	0	3	5
95	R:R:E145	R:R:T215	9.88	No	No	0	3	4
96	R:R:C148	R:R:C226	7.28	No	No	0	9	9
97	R:R:N149	R:R:Q214	3.96	No	No	0	6	4
98	R:R:V150	R:R:Y210	3.79	No	No	0	5	5
99	R:R:I152	R:R:L209	5.71	No	No	0	5	4
100	R:R:H227	R:R:I152	9.28	No	No	0	5	5
101	R:R:G153	R:R:L209	5.13	No	No	0	6	4
102	R:R:G153	R:R:Y210	4.35	No	No	0	6	5
103	R:R:F155	R:R:Y156	11.35	Yes	No	0	6	5
104	R:R:F155	R:R:L330	6.09	Yes	No	0	6	5
105	R:R:F243	R:R:Y156	10.32	Yes	No	0	6	5
106	R:R:Y156	R:R:Y326	5.96	No	Yes	0	5	4
107	R:R:M159	R:R:Y160	4.79	No	Yes	0	7	7
108	R:R:M159	R:R:S333	4.6	No	No	0	7	8
109	R:R:L246	R:R:Y160	16.41	No	Yes	0	5	7
110	R:R:V250	R:R:Y160	8.83	No	Yes	0	5	7
111	R:R:N304	R:R:Y160	6.98	No	Yes	0	8	7
112	R:R:C161	R:R:F165	4.19	Yes	Yes	4	7	7
113	R:R:C161	R:R:W199	7.84	Yes	No	4	7	9
114	R:R:C161	R:R:I202	6.55	Yes	No	0	7	8
115	R:R:F251	R:R:I163	3.77	Yes	No	1	8	7
116	R:R:I163	R:R:Y296	4.84	No	Yes	1	7	9
117	R:R:F300	R:R:I163	11.3	Yes	No	1	9	7
118	R:R:I198	R:R:L164	7.14	No	No	0	7	6
119	R:R:L164	R:R:V250	4.47	No	No	0	6	5
120	R:R:F165	R:R:S195	3.96	Yes	No	4	7	7
121	R:R:F165	R:R:I198	7.54	Yes	No	0	7	7
122	R:R:F165	R:R:W199	9.02	Yes	No	4	7	9
123	R:R:M166	R:R:Y296	7.18	Yes	Yes	1	8	9
124	R:R:F300	R:R:M166	3.73	Yes	Yes	1	9	8
125	R:R:M166	R:R:N336	7.01	Yes	Yes	1	8	9
126	R:R:D340	R:R:M166	5.54	Yes	Yes	1	9	8
127	R:R:M166	R:R:Y344	9.58	Yes	Yes	1	8	9
128	R:R:P254	R:R:T167	5.25	No	No	0	9	7
129	R:R:T167	R:R:T258	6.28	No	No	1	7	8
130	R:R:T167	R:R:Y296	3.75	No	Yes	1	7	9
131	R:R:S170	R:R:T258	9.59	Yes	No	0	9	8
132	R:R:S170	R:R:Y262	6.36	Yes	Yes	0	9	9
133	R:R:R173	R:R:Y262	8.23	No	Yes	1	9	9
134	R:R:M265	R:R:R173	4.96	Yes	No	1	8	9
135	R:R:R173	R:R:Y344	6.17	No	Yes	1	9	9
136	R:R:W175	R:R:Y174	7.72	No	No	0	5	8
137	R:R:V178	R:R:Y174	12.62	No	No	0	7	8
138	R:R:L264	R:R:Y174	8.21	No	No	0	4	8
139	R:R:N179	R:R:W175	5.65	No	No	0	6	5
140	R:R:N179	R:R:V178	5.91	No	No	0	6	7
141	R:R:H183	R:R:M181	14.44	No	No	0	6	5
142	R:R:H183	R:R:K186	9.17	No	No	0	6	7
143	R:R:H183	R:R:K187	22.27	No	No	0	6	6
144	R:R:T206	R:R:Y210	6.24	No	No	0	7	5
145	R:R:P208	R:R:Y242	11.13	No	Yes	0	7	5
146	R:R:L209	R:R:Y242	12.89	No	Yes	0	4	5
147	R:R:L234	R:R:V212	4.47	Yes	No	0	5	4
148	R:R:H227	R:R:Q214	7.42	No	No	0	5	4
149	R:R:L230	R:R:Q214	3.99	Yes	No	0	5	4
150	R:R:I216	R:R:P231	5.08	No	No	0	1	4
151	R:R:F217	R:R:P219	4.33	No	No	0	1	1
152	R:R:F217	R:R:T224	3.89	No	No	0	1	5
153	R:R:I218	R:R:V229	4.61	Yes	No	0	4	4
154	R:R:D228	R:R:T225	7.23	Yes	No	0	4	4
155	R:R:T225	R:R:V229	9.52	No	No	0	4	4
156	R:R:L230	R:R:P231	4.93	Yes	No	0	5	4
157	R:R:L230	R:R:L234	6.92	Yes	Yes	0	5	5
158	R:R:L230	R:R:L235	8.3	Yes	No	0	5	4
159	R:R:D238	R:R:L234	8.14	No	Yes	0	2	5
160	R:R:L234	R:R:M239	8.48	Yes	No	0	5	4
161	R:R:K315	R:R:V236	4.55	No	No	0	2	3
162	R:R:F243	R:R:M239	3.73	Yes	No	2	6	4
163	R:R:M239	R:R:Y311	4.79	No	Yes	2	4	5
164	R:R:F240	R:R:N241	6.04	No	No	0	3	3
165	R:R:F240	R:R:K315	13.65	No	No	0	3	2
166	R:R:F243	R:R:Y242	7.22	Yes	Yes	0	6	5
167	R:R:L246	R:R:Y242	4.69	No	Yes	0	5	5
168	R:R:F243	R:R:L307	3.65	Yes	No	0	6	5
169	R:R:F243	R:R:Y311	9.28	Yes	Yes	2	6	5
170	R:R:I248	R:R:L244	4.28	No	No	0	4	5
171	R:R:L244	R:R:V308	4.47	No	No	0	5	6
172	R:R:F251	R:R:F300	4.29	Yes	Yes	1	8	9
173	R:R:F251	R:R:T301	5.19	Yes	No	0	8	5
174	R:R:F251	R:R:N304	20.54	Yes	No	0	8	8
175	R:R:F253	R:R:P254	4.33	No	No	0	6	9
176	R:R:F253	R:R:L257	7.31	No	No	0	6	7
177	R:R:A255	R:R:Y296	4	No	Yes	0	7	9
178	R:R:F256	R:R:L257	6.09	No	No	0	3	7
179	R:R:T258	R:R:Y296	12.48	No	Yes	1	8	9
180	R:R:M265	R:R:Y262	4.79	Yes	Yes	1	8	9
181	R:R:I289	R:R:Y262	8.46	No	Yes	1	8	9
182	R:R:V292	R:R:Y262	8.83	No	Yes	0	8	9
183	R:R:I289	R:R:M265	4.37	No	Yes	1	8	8
184	R:R:I266	R:R:I289	7.36	No	No	0	5	8
185	R:R:L269	R:R:R282	4.86	No	Yes	0	8	6
186	R:R:I286	R:R:L269	4.28	No	No	0	6	8
187	R:R:I286	R:R:R270	3.76	No	No	0	6	4
188	R:R:M274	R:R:S271	4.6	No	No	0	4	4
189	R:R:M274	R:R:R282	13.65	No	Yes	0	4	6
190	R:R:R282	R:R:S278	6.59	Yes	No	0	6	4
191	R:R:E279	R:R:K280	6.75	No	No	0	3	4
192	R:R:E279	R:R:K283	9.45	No	No	0	3	5
193	R:R:L288	R:R:V347	7.45	No	No	0	8	7
194	R:R:V292	R:R:Y344	10.09	No	Yes	0	8	9
195	R:R:L293	R:R:L297	4.15	Yes	No	0	8	5
196	R:R:I298	R:R:M295	4.37	No	No	0	6	6
197	R:R:I339	R:R:M295	5.83	No	No	0	6	6
198	R:R:F300	R:R:S333	5.28	Yes	No	0	9	8
199	R:R:F300	R:R:N336	10.87	Yes	Yes	1	9	9
200	R:R:N304	R:R:S303	4.47	No	No	0	8	7
201	R:R:S303	R:R:S333	4.89	No	No	0	7	8
202	R:R:L306	R:R:L325	4.15	No	No	0	4	5
203	R:R:L307	R:R:Y326	12.89	No	Yes	0	5	4
204	R:R:H310	R:R:Y311	11.98	Yes	Yes	2	4	5
205	R:R:H310	R:R:I314	6.63	Yes	No	0	4	2
206	R:R:H310	R:R:V322	5.54	Yes	No	0	4	4
207	R:R:H310	R:R:Y323	11.98	Yes	No	2	4	4
208	R:R:F312	R:R:L313	3.65	No	No	0	3	1
209	R:R:L313	R:R:Q317	3.99	No	No	0	1	1
210	R:R:L313	R:R:Q319	6.65	No	No	0	1	4
211	R:R:Q317	R:R:S316	10.11	No	No	0	1	1
212	R:R:H321	R:R:Q319	12.36	No	No	0	4	4
213	R:R:I327	R:R:Y323	7.25	No	No	0	4	4
214	R:R:L330	R:R:Y326	11.72	No	Yes	0	5	4
215	R:R:D340	R:R:N336	12.12	Yes	Yes	1	9	9
216	R:R:D340	R:R:Y344	6.9	Yes	Yes	1	9	9
217	R:R:F342	R:R:F346	4.29	No	No	0	6	7
218	R:R:Y344	R:R:Y345	3.97	Yes	Yes	1	9	7
219	R:R:F351	R:R:Y345	5.16	Yes	Yes	1	8	7
220	R:R:F346	R:R:F351	5.36	No	Yes	0	7	8
221	R:R:D350	R:R:S348	7.36	No	No	0	6	8
222	R:R:T224	R:R:W141	3.64	No	Yes	0	5	9
223	R:R:L288	R:R:R284	3.64	No	No	0	8	7
224	R:R:A120	R:R:C161	3.61	No	Yes	0	8	7
225	R:R:G249	R:R:I248	3.53	No	No	0	5	4
226	R:R:L169	R:R:Y113	3.52	No	Yes	0	8	7
227	R:R:L293	R:R:Y262	3.52	Yes	Yes	0	8	9
228	R:R:L297	R:R:Y296	3.52	No	Yes	0	5	9
229	R:R:P302	R:R:T301	3.5	No	No	0	9	5
230	R:R:E279	R:R:R282	3.49	No	Yes	0	3	6
231	R:R:C338	R:R:V88	3.42	No	No	0	7	6
232	R:R:L151	R:R:W127	3.42	No	Yes	0	5	7
233	R:R:A261	R:R:S170	3.42	No	Yes	0	7	9
234	R:R:G138	R:R:N139	3.39	No	Yes	0	4	5
235	R:R:I207	R:R:P208	3.39	No	No	0	4	7
236	R:R:L332	R:R:P302	3.28	No	No	0	8	9
237	R:R:S170	R:R:V171	3.23	Yes	No	0	9	6
238	R:R:V292	R:R:V343	3.21	No	No	0	8	8
239	R:R:T75	R:R:V76	3.17	No	No	0	5	4
240	R:R:T334	R:R:V85	3.17	No	No	0	7	8
241	R:R:T104	R:R:V111	3.17	No	No	0	6	7
242	R:R:T291	R:R:V343	3.17	No	No	0	5	8
243	R:R:A66	R:R:L221	3.15	No	Yes	0	4	3
244	R:R:C299	R:R:N336	3.15	No	Yes	0	9	9
245	R:R:I314	R:R:V236	3.07	No	No	0	2	3
246	R:R:I132	R:R:T83	3.04	No	No	0	7	5
247	R:R:M95	R:R:V99	3.04	No	No	0	6	8
248	R:R:L246	R:R:V205	2.98	No	No	0	5	5
249	R:R:D62	R:R:S65	2.94	No	No	0	7	5
250	R:R:A110	R:R:H108	2.93	No	No	0	8	7
251	R:R:A133	R:R:H137	2.93	No	No	0	4	4
252	R:R:I177	R:R:M265	2.92	No	Yes	0	8	8
253	R:R:M268	R:R:M274	2.89	No	No	0	5	4
254	R:R:I218	R:R:L221	2.85	Yes	Yes	0	4	3
255	R:R:I223	R:R:L221	2.85	No	Yes	0	3	3
256	R:R:G144	R:R:W141	2.81	No	Yes	0	8	9
257	R:R:L101	R:R:L97	2.77	No	No	0	4	7
258	R:R:A115	R:R:F100	2.77	No	Yes	0	7	6
259	R:R:F64	R:R:S67	2.64	No	No	0	2	4
260	R:R:F86	R:R:V125	2.62	No	No	0	6	6
261	R:R:F342	R:R:V88	2.62	No	No	0	6	6
262	R:R:E232	R:R:Q233	2.55	No	No	0	1	1
263	R:R:I266	R:R:R270	2.51	No	No	0	5	4
264	R:R:K186	R:R:R185	2.48	No	No	0	7	3
265	R:R:V171	R:R:W175	2.45	No	No	0	6	5
266	R:R:F251	R:R:L252	2.44	Yes	No	0	8	4
267	R:R:L264	R:R:R267	2.43	No	No	0	4	4
268	R:R:L306	R:R:Y326	2.34	No	Yes	0	4	4
269	R:R:H349	R:R:R352	2.26	No	No	0	5	8
270	R:R:G89	R:R:P91	2.03	No	No	0	8	5
271	R:R:R103	R:R:W98	2	No	No	0	5	3
272	R:R:A329	R:R:P302	1.87	No	No	0	7	9
273	R:R:G237	R:R:V236	1.84	No	No	0	1	3
274	R:R:G249	R:R:V250	1.84	No	No	0	5	5
275	R:R:G71	R:R:T75	1.82	No	No	0	3	5
276	R:R:G157	R:R:T206	1.82	No	No	0	5	7
277	R:R:G182	R:R:M181	1.75	No	No	0	4	5
278	R:R:G94	R:R:L122	1.71	No	No	0	4	8
279	R:R:A273	R:R:S271	1.71	No	No	0	4	4
280	R:R:A324	R:R:V68	1.7	No	No	0	1	4
281	R:R:A247	R:R:V308	1.7	No	No	0	5	6
282	R:R:K187	R:R:P109	1.67	No	No	0	6	7
283	R:R:C299	R:R:I298	1.64	No	No	0	9	6
284	R:R:C299	R:R:I339	1.64	No	No	0	9	6
285	R:R:C338	R:R:I339	1.64	No	No	0	7	6
286	R:R:N179	R:R:P180	1.63	No	No	0	6	8
287	R:R:A220	R:R:I218	1.62	No	Yes	0	1	4
288	R:R:A355	R:R:M95	1.61	No	No	0	7	6
289	R:R:V87	R:R:V88	1.6	No	No	0	5	6
290	R:R:V211	R:R:V212	1.6	No	No	0	3	4
291	R:R:V309	R:R:V322	1.6	No	No	0	4	4
292	R:R:A259	R:R:L293	1.58	No	Yes	0	4	8
293	R:R:A285	R:R:L269	1.58	No	No	0	7	8
294	R:R:T74	R:R:T75	1.57	No	No	0	4	5
295	R:R:I80	R:R:V76	1.54	No	No	0	5	4
296	R:R:I84	R:R:V85	1.54	No	No	0	5	8
297	R:R:I177	R:R:V176	1.54	No	No	0	8	8
298	R:R:I266	R:R:V290	1.54	No	No	0	5	5
299	R:R:K187	R:R:S184	1.53	No	No	0	6	4
300	R:R:L264	R:R:S260	1.5	No	No	0	4	4
301	R:R:L335	R:R:V85	1.49	No	No	0	5	8
302	R:R:L201	R:R:V205	1.49	No	No	0	5	5
303	R:R:L293	R:R:V263	1.49	Yes	No	0	8	3
304	R:R:L221	R:R:T70	1.47	Yes	No	0	3	7
305	R:R:I190	R:R:I194	1.47	No	No	0	4	5
306	R:R:I112	R:R:K107	1.45	No	No	0	6	6
307	R:R:I192	R:R:L196	1.43	No	No	0	3	5
308	R:R:F351	R:R:S348	1.32	Yes	No	0	8	8
309	R:R:D275	R:R:E276	1.3	No	No	0	4	1
310	R:R:I132	R:R:Y82	1.21	No	Yes	0	7	7
311	R:R:N189	R:R:R185	1.21	No	No	0	4	3
312	R:R:F217	R:R:N222	1.21	No	No	0	1	5
313	R:R:F346	R:R:R352	1.07	No	No	0	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.527	10	2	0
2	R:R:Y82	7.6575	4	5	7
3	R:R:F100	8.51	5	1	6
4	R:R:Y113	7.384	5	0	7
5	R:R:D121	6.144	5	0	9
6	R:R:W127	7.088	5	0	7
7	R:R:F128	7.7	4	5	8
8	R:R:Y134	9.852	5	3	5
9	R:R:H135	7.252	5	3	5
10	R:R:N139	8.25333	6	3	5
11	R:R:W141	6.578	5	0	9
12	R:R:F155	6.63	4	0	6
13	R:R:Y160	9.2525	4	0	7
14	R:R:C161	5.5475	4	4	7
15	R:R:F165	7.6	5	4	7
16	R:R:M166	6.685	6	1	8
17	R:R:S170	5.65	4	0	9
18	R:R:I218	3.4225	4	0	4
19	R:R:L221	2.58	4	0	3
20	R:R:D228	6.7575	4	3	4
21	R:R:L230	6.035	4	0	5
22	R:R:L234	7.0025	4	0	5
23	R:R:Y242	8.9825	4	0	5
24	R:R:F243	6.84	5	2	6
25	R:R:F251	7.246	5	1	8
26	R:R:Y262	6.69833	6	1	9
27	R:R:M265	4.26	4	1	8
28	R:R:R282	7.1475	4	0	6
29	R:R:L293	2.685	4	0	8
30	R:R:Y296	5.96167	6	1	9
31	R:R:F300	7.094	5	1	9
32	R:R:H310	8.728	5	2	4
33	R:R:Y311	7.71	4	2	5
34	R:R:Y326	8.2275	4	0	4
35	R:R:N336	8.2875	4	1	9
36	R:R:D340	7.8025	4	1	9
37	R:R:Y344	7.342	5	1	9
38	R:R:Y345	5.94333	6	1	7
39	R:R:F351	7.086	5	1	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:V229	13.5819	7.83	Yes	No	0	0	4
2	R:R:H135	R:R:Y134	14.4804	10.89	Yes	Yes	3	5	5
3	L:L:?1	R:R:Y311	24.0299	4.79	Yes	Yes	2	0	5
4	R:R:F243	R:R:Y311	33.1984	9.28	Yes	Yes	2	6	5
5	R:R:F243	R:R:Y156	48.364	10.32	Yes	No	0	6	5
6	R:R:F155	R:R:Y156	44.6437	11.35	Yes	No	0	6	5
7	R:R:F128	R:R:F155	14.8437	5.36	Yes	Yes	0	8	6
8	R:R:F155	R:R:K131	30.2285	3.72	Yes	No	0	6	7
9	R:R:F243	R:R:Y242	85.6006	7.22	Yes	Yes	0	6	5
10	R:R:L246	R:R:Y242	98.6612	4.69	No	Yes	0	5	5
11	R:R:L246	R:R:Y160	100	16.41	No	Yes	0	5	7
12	R:R:M159	R:R:Y160	43.8775	4.79	No	Yes	0	7	7
13	R:R:M159	R:R:S333	43.9209	4.6	No	No	0	7	8
14	R:R:F300	R:R:S333	44.3336	5.28	Yes	No	0	9	8
15	R:R:F300	R:R:M166	77.7354	3.73	Yes	Yes	1	9	8
16	R:R:N304	R:R:Y160	64.7499	6.98	No	Yes	0	8	7
17	R:R:F251	R:R:N304	64.5603	20.54	Yes	No	0	8	8
18	R:R:F251	R:R:F300	45.1275	4.29	Yes	Yes	1	8	9
19	R:R:F300	R:R:N336	11.3446	10.87	Yes	Yes	1	9	9
20	R:R:M166	R:R:Y344	70.1033	9.58	Yes	Yes	1	8	9
21	R:R:Y344	R:R:Y345	39.6319	3.97	Yes	Yes	1	9	7
22	R:R:F351	R:R:Y345	13.7655	5.16	Yes	Yes	1	8	7
23	R:R:V250	R:R:Y160	19.9443	8.83	No	Yes	0	5	7
24	R:R:L164	R:R:V250	14.4231	4.47	No	No	0	6	5
25	R:R:I198	R:R:L164	13.4891	7.14	No	No	0	7	6
26	R:R:F165	R:R:I198	12.5511	7.54	Yes	No	0	7	7
27	R:R:M114	R:R:Y345	21.6603	7.18	No	Yes	1	8	7
28	R:R:L169	R:R:M114	21.7808	5.65	No	No	0	8	8
29	R:R:L169	R:R:Y113	20.8566	3.52	No	Yes	0	8	7
30	R:R:Q172	R:R:Y113	12.1285	11.27	No	Yes	0	8	7
31	R:R:A110	R:R:Q172	11.1392	4.55	No	No	0	8	8
32	R:R:A110	R:R:H108	10.1479	2.93	No	No	0	8	7
33	R:R:G153	R:R:L209	11.3149	5.13	No	No	0	6	4
34	R:R:G153	R:R:Y210	10.3059	4.35	No	No	0	6	5
35	R:R:W141	R:R:Y134	13.2679	7.72	Yes	Yes	0	9	5
36	R:R:F251	R:R:I163	19.7863	3.77	Yes	No	1	8	7
37	R:R:I163	R:R:Y296	19.8969	4.84	No	Yes	1	7	9
38	R:R:T258	R:R:Y296	11.2142	12.48	No	Yes	1	8	9
39	R:R:S170	R:R:T258	11.1431	9.59	Yes	No	0	9	8
40	R:R:R173	R:R:Y344	31.1447	6.17	No	Yes	1	9	9
41	R:R:R173	R:R:Y262	15.2781	8.23	No	Yes	1	9	9
42	R:R:V292	R:R:Y344	17.6793	10.09	No	Yes	0	8	9
43	R:R:V292	R:R:Y262	15.4697	8.83	No	Yes	0	8	9
44	R:R:M265	R:R:R173	15.1991	4.96	Yes	No	1	8	9
45	R:R:I289	R:R:Y262	37.4262	8.46	No	Yes	1	8	9
46	R:R:I289	R:R:M265	12.8986	4.37	No	Yes	1	8	8
47	R:R:I266	R:R:I289	47.2503	7.36	No	No	0	5	8
48	R:R:I266	R:R:R270	40.9767	2.51	No	No	0	5	4
49	R:R:I286	R:R:R270	37.831	3.76	No	No	0	6	4
50	R:R:I286	R:R:L269	34.6834	4.28	No	No	0	6	8
51	R:R:L269	R:R:R282	28.3762	4.86	No	Yes	0	8	6
52	R:R:M274	R:R:R282	12.7367	13.65	No	Yes	0	4	6
53	R:R:L209	R:R:Y242	15.677	12.89	No	Yes	0	4	5
54	R:R:H135	R:R:K131	28.3367	3.93	Yes	No	0	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:S65	5.26	2	Yes	No	0	5	0	1
L:L:?1	R:R:V68	4.35	2	Yes	No	0	4	0	1
L:L:?1	R:R:H227	5.25	2	Yes	No	0	5	0	1
L:L:?1	R:R:V229	7.83	2	Yes	No	0	4	0	1
L:L:?1	R:R:E232	4.64	2	Yes	No	0	1	0	1
L:L:?1	R:R:L235	17.78	2	Yes	No	0	4	0	1
L:L:?1	R:R:H310	7.51	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y311	4.79	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:S320	16.65	2	Yes	No	0	2	0	1
L:L:?1	R:R:Y323	21.21	2	Yes	No	0	4	0	1
R:R:F64	R:R:V68	7.87	0	No	No	2	4	2	1
R:R:H227	R:R:I152	9.28	0	No	No	5	5	1	2
R:R:H227	R:R:Q214	7.42	0	No	No	5	4	1	2
R:R:L230	R:R:Q214	3.99	0	Yes	No	5	4	2	2
R:R:I218	R:R:V229	4.61	0	Yes	No	4	4	2	1
R:R:T225	R:R:V229	9.52	0	No	No	4	4	2	1
R:R:L230	R:R:L235	8.3	0	Yes	No	5	4	2	1
R:R:F243	R:R:M239	3.73	2	Yes	No	6	4	2	2
R:R:M239	R:R:Y311	4.79	2	No	Yes	4	5	2	1
R:R:F243	R:R:Y311	9.28	2	Yes	Yes	6	5	2	1
R:R:H310	R:R:Y311	11.98	2	Yes	Yes	4	5	1	1
R:R:H310	R:R:I314	6.63	2	Yes	No	4	2	1	2
R:R:H310	R:R:V322	5.54	2	Yes	No	4	4	1	2
R:R:H310	R:R:Y323	11.98	2	Yes	No	4	4	1	1
R:R:I327	R:R:Y323	7.25	0	No	No	4	4	2	1
R:R:D62	R:R:S65	2.94	0	No	No	7	5	2	1
R:R:E232	R:R:Q233	2.55	0	No	No	1	1	1	2
R:R:A324	R:R:V68	1.7	0	No	No	1	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9E7R_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.65
Number of Linked Nodes	279
Number of Links	313
Number of Hubs	39
Number of Links mediated by Hubs	153
Number of Communities	5
Number of Nodes involved in Communities	37
Number of Links involved in Communities	51

Path Summary
Number Of Nodes in MetaPath	55
Number Of Links MetaPath	54
Number of Shortest Paths	82032
Length Of Smallest Path	3
Average Path Length	15.6425
Length of Longest Path	32
Minimum Path Strength	1.515
Average Path Strength	7.05178
Maximum Path Strength	19.495
Minimum Path Correlation	0.7
Average Path Correlation	0.929367
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	47.3948
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.534
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P55085
Sequence	>9E7R_nogp_Chain_R V D E F S A S V L T G K L T T V F L P I V Y T I V F V V G L P S N G M A L W V F L F R T K K K H P A V I Y M A N L A L A D L L S V I W F P L K I A Y H I H G N N W I Y G E A L C N V L I G F F Y G N M Y C S I L F M T C L S V Q R Y W V I V N P M G H S R K K A N I A I G I S L A I W L L I L L V T I P L Y V V K Q T I F I P A L N I T T C H D V L P E Q L L V G D M F N Y F L S L A I G V F L F P A F L T A S A Y V L M I R M L R S S A M D E N S E K K R K R A I K L I V T V L A M Y L I C F T P S N L L L V V H Y F L I K S Q G Q S H V Y A L Y I V A L C L S T L N S C I D P F V Y Y F V S H D F R D H A K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5NDD	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	AZ8838; Na	-	2.8	2017-05-03	doi.org/10.1038/nature22309
	5NDZ	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	AZ3451; Na	-	3.6	2017-05-03	doi.org/10.1038/nature22309
	5NJ6	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-	-	4	2017-05-03	doi.org/10.1038/nature22309
	9D0A	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.1	2025-05-07	doi.org/10.1038/s41467-025-59138-x
	9D0A (No Gprot)	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-		3.1	2025-05-07	doi.org/10.1038/s41467-025-59138-x
	9E7R	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	GB88	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.18	2025-05-07	doi.org/10.1038/s41467-025-59138-x
	9E7R (No Gprot)	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	GB88	-		3.18	2025-05-07	doi.org/10.1038/s41467-025-59138-x
	8ZMD	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.25	2025-05-28	To be published
	8ZMD (No Gprot)	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-		3.25	2025-05-28	To be published
	8ZME	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.2	2025-05-28	To be published
	8ZME (No Gprot)	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-		3.2	2025-05-28	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9E7R_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.