psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F59	R:R:P219	7.22	No	No	0	7	1
2	R:R:D62	R:R:S65	10.31	No	No	0	7	5
3	R:R:S65	R:R:Y323	6.36	No	Yes	0	5	4
4	R:R:V68	R:R:Y323	7.57	No	Yes	0	4	4
5	R:R:L69	R:R:N139	6.87	No	Yes	0	4	5
6	R:R:L69	R:R:Y323	3.52	No	Yes	0	4	4
7	R:R:K72	R:R:V76	4.55	No	No	0	2	4
8	R:R:F77	R:R:L73	3.65	No	No	0	4	3
9	R:R:N139	R:R:T74	10.24	Yes	No	0	5	4
10	R:R:F77	R:R:V81	6.55	No	No	0	4	6
11	R:R:L78	R:R:Y82	4.69	No	Yes	1	5	7
12	R:R:H135	R:R:L78	9	Yes	No	1	5	5
13	R:R:I327	R:R:L78	4.28	No	No	0	4	5
14	R:R:H135	R:R:P79	4.58	Yes	No	0	5	5
15	R:R:I136	R:R:P79	5.08	No	No	0	4	5
16	R:R:C331	R:R:V81	5.12	No	No	0	6	6
17	R:R:F128	R:R:Y82	5.16	Yes	Yes	1	8	7
18	R:R:K131	R:R:Y82	17.91	No	Yes	1	7	7
19	R:R:H135	R:R:Y82	4.36	Yes	Yes	1	5	7
20	R:R:C331	R:R:Y82	9.41	No	Yes	0	6	7
21	R:R:T334	R:R:Y82	6.24	No	Yes	1	7	7
22	R:R:I132	R:R:T83	7.6	No	No	0	7	5
23	R:R:F128	R:R:V85	6.55	Yes	No	0	8	8
24	R:R:C338	R:R:V85	5.12	No	No	0	7	8
25	R:R:F86	R:R:L90	4.87	No	Yes	5	6	6
26	R:R:F86	R:R:V125	5.24	No	No	5	6	6
27	R:R:F86	R:R:P129	8.67	No	No	0	6	8
28	R:R:C338	R:R:V88	5.12	No	No	0	7	6
29	R:R:A89	R:R:S337	3.42	No	No	0	8	9
30	R:R:L90	R:R:P91	3.28	Yes	No	0	6	5
31	R:R:L90	R:R:V125	4.47	Yes	No	5	6	6
32	R:R:P341	R:R:S92	7.13	No	No	0	9	7
33	R:R:A118	R:R:N93	4.69	No	Yes	2	8	9
34	R:R:D121	R:R:N93	14.81	Yes	Yes	2	9	9
35	R:R:N93	R:R:Y344	6.98	Yes	Yes	2	9	9
36	R:R:G94	R:R:L122	3.42	No	No	0	4	8
37	R:R:F351	R:R:M95	3.73	No	No	0	8	6
38	R:R:A96	R:R:F351	4.16	No	No	0	9	8
39	R:R:L101	R:R:L97	5.54	No	No	0	4	7
40	R:R:F102	R:R:W98	8.02	No	No	0	4	3
41	R:R:R103	R:R:W98	16.99	No	No	4	5	3
42	R:R:H354	R:R:W98	6.35	Yes	No	4	5	3
43	R:R:R103	R:R:V99	3.92	No	No	4	5	8
44	R:R:H354	R:R:V99	11.07	Yes	No	4	5	8
45	R:R:F100	R:R:V111	3.93	Yes	No	0	6	7
46	R:R:F100	R:R:M114	7.46	Yes	Yes	2	6	8
47	R:R:F100	R:R:Y344	8.25	Yes	Yes	2	6	9
48	R:R:F100	R:R:S348	5.28	Yes	No	0	6	8
49	R:R:F102	R:R:L101	8.53	No	No	0	4	4
50	R:R:H354	R:R:R103	9.03	Yes	No	4	5	5
51	R:R:T104	R:R:V111	7.93	No	No	0	6	7
52	R:R:D350	R:R:T104	7.23	No	No	0	6	6
53	R:R:H349	R:R:K106	5.24	No	No	0	5	7
54	R:R:D350	R:R:K106	9.68	No	No	0	6	7
55	R:R:P109	R:R:Q172	11.05	No	Yes	6	7	8
56	R:R:K187	R:R:P109	3.35	No	No	6	6	7
57	R:R:I112	R:R:I192	5.89	No	No	0	6	3
58	R:R:C168	R:R:Y113	12.1	No	Yes	0	7	7
59	R:R:Q172	R:R:Y113	3.38	Yes	Yes	0	8	7
60	R:R:A191	R:R:Y113	5.34	No	Yes	0	8	7
61	R:R:I194	R:R:Y113	6.04	No	Yes	0	5	7
62	R:R:L169	R:R:M114	7.07	No	Yes	0	8	8
63	R:R:M114	R:R:Y344	7.18	Yes	Yes	2	8	9
64	R:R:M114	R:R:V347	6.09	Yes	No	0	8	7
65	R:R:F165	R:R:N116	13.29	Yes	No	3	7	9
66	R:R:N116	R:R:S195	7.45	No	No	3	9	7
67	R:R:N116	R:R:W199	5.65	No	Yes	3	9	9
68	R:R:D340	R:R:L117	9.5	Yes	No	2	9	9
69	R:R:L117	R:R:Y344	9.38	No	Yes	2	9	9
70	R:R:A118	R:R:Y344	4	No	Yes	2	8	9
71	R:R:L119	R:R:L123	6.92	No	No	0	6	7
72	R:R:L119	R:R:W199	3.42	No	Yes	0	6	9
73	R:R:D121	R:R:N158	4.04	Yes	Yes	2	9	8
74	R:R:D121	R:R:S337	5.89	Yes	No	0	9	9
75	R:R:D121	R:R:D340	10.65	Yes	Yes	2	9	9
76	R:R:D121	R:R:Y344	3.45	Yes	Yes	2	9	9
77	R:R:F154	R:R:L123	6.09	No	No	0	5	7
78	R:R:L147	R:R:W127	3.42	No	Yes	0	6	7
79	R:R:V150	R:R:W127	6.13	No	Yes	0	5	7
80	R:R:L151	R:R:W127	7.97	No	Yes	0	5	7
81	R:R:F154	R:R:W127	5.01	No	Yes	0	5	7
82	R:R:F128	R:R:K131	9.93	Yes	No	1	8	7
83	R:R:F128	R:R:T334	6.49	Yes	No	1	8	7
84	R:R:L130	R:R:Y143	5.86	No	Yes	0	7	7
85	R:R:H135	R:R:Y134	10.89	Yes	Yes	1	5	5
86	R:R:N139	R:R:Y134	5.81	Yes	Yes	1	5	5
87	R:R:W141	R:R:Y134	8.68	Yes	Yes	1	9	5
88	R:R:C226	R:R:Y134	4.03	No	Yes	1	9	5
89	R:R:D228	R:R:Y134	8.05	No	Yes	0	4	5
90	R:R:H135	R:R:N139	6.38	Yes	Yes	1	5	5
91	R:R:I223	R:R:N140	8.5	No	No	0	3	4
92	R:R:W141	R:R:Y143	15.43	Yes	Yes	0	9	7
93	R:R:C148	R:R:W141	5.22	No	Yes	1	9	9
94	R:R:L151	R:R:W141	4.56	No	Yes	0	5	9
95	R:R:C226	R:R:W141	5.22	No	Yes	1	9	9
96	R:R:I142	R:R:Y143	3.63	No	Yes	0	1	7
97	R:R:E145	R:R:K213	10.8	No	No	1	3	5
98	R:R:E145	R:R:T215	8.47	No	No	1	3	4
99	R:R:C148	R:R:T215	3.38	No	No	1	9	4
100	R:R:C148	R:R:C226	7.28	No	No	1	9	9
101	R:R:N149	R:R:Q214	6.6	No	No	0	6	4
102	R:R:I152	R:R:Q214	5.49	No	No	0	5	4
103	R:R:H227	R:R:I152	9.28	No	No	0	5	5
104	R:R:G153	R:R:Y210	5.79	No	No	0	6	5
105	R:R:F155	R:R:Y156	12.38	No	Yes	0	6	5
106	R:R:F155	R:R:L330	3.65	No	No	0	6	5
107	R:R:L209	R:R:Y156	5.86	No	Yes	0	4	5
108	R:R:H227	R:R:Y156	8.71	No	Yes	0	5	5
109	R:R:F243	R:R:Y156	8.25	Yes	Yes	0	6	5
110	R:R:N158	R:R:S162	5.96	Yes	No	2	8	9
111	R:R:N158	R:R:N336	10.9	Yes	No	2	8	9
112	R:R:M159	R:R:Y160	8.38	No	Yes	0	7	7
113	R:R:L246	R:R:Y160	10.55	No	Yes	0	5	7
114	R:R:V250	R:R:Y160	6.31	No	Yes	0	5	7
115	R:R:N304	R:R:Y160	4.65	No	Yes	0	8	7
116	R:R:C161	R:R:F165	5.59	No	Yes	3	7	7
117	R:R:C161	R:R:W199	7.84	No	Yes	3	7	9
118	R:R:C161	R:R:I202	4.91	No	No	0	7	8
119	R:R:N336	R:R:S162	4.47	No	No	2	9	9
120	R:R:I163	R:R:P254	3.39	No	Yes	0	7	9
121	R:R:F300	R:R:I163	11.3	Yes	No	0	9	7
122	R:R:I198	R:R:L164	4.28	No	No	0	7	6
123	R:R:L164	R:R:V250	4.47	No	No	0	6	5
124	R:R:L164	R:R:P254	3.28	No	Yes	0	6	9
125	R:R:F165	R:R:S195	5.28	Yes	No	3	7	7
126	R:R:F165	R:R:I198	11.3	Yes	No	0	7	7
127	R:R:F165	R:R:W199	5.01	Yes	Yes	3	7	9
128	R:R:P254	R:R:T167	5.25	Yes	No	0	9	7
129	R:R:T167	R:R:T258	6.28	No	No	0	7	8
130	R:R:S170	R:R:Y262	10.17	No	Yes	0	9	9
131	R:R:E176	R:R:Q172	10.19	No	Yes	0	8	8
132	R:R:K187	R:R:Q172	8.14	No	Yes	6	6	8
133	R:R:K281	R:R:R173	3.71	No	No	0	5	9
134	R:R:R173	R:R:V347	9.15	No	No	0	9	7
135	R:R:I177	R:R:L269	5.71	No	No	0	8	8
136	R:R:N179	R:R:V178	4.43	No	No	0	6	7
137	R:R:K187	R:R:M181	4.32	No	No	0	6	5
138	R:R:H183	R:R:K186	7.86	No	No	0	6	7
139	R:R:T206	R:R:Y210	6.24	No	No	0	7	5
140	R:R:I207	R:R:P208	3.39	No	No	0	4	7
141	R:R:P208	R:R:Y242	6.95	No	Yes	0	7	5
142	R:R:L209	R:R:Y242	10.55	No	Yes	0	4	5
143	R:R:K213	R:R:T215	6.01	No	No	1	5	4
144	R:R:K213	R:R:P231	3.35	No	No	0	5	4
145	R:R:I216	R:R:P231	6.77	No	No	0	1	4
146	R:R:F217	R:R:P219	7.22	No	No	0	1	1
147	R:R:F217	R:R:Q222	3.51	No	No	0	1	5
148	R:R:F217	R:R:T224	5.19	No	No	0	1	5
149	R:R:I218	R:R:P219	3.39	No	No	0	4	1
150	R:R:I218	R:R:L221	8.56	No	Yes	0	4	3
151	R:R:I218	R:R:T225	4.56	No	No	0	4	4
152	R:R:I223	R:R:L221	5.71	No	Yes	0	3	3
153	R:R:T225	R:R:V229	9.52	No	No	0	4	4
154	R:R:H227	R:R:Y326	4.36	No	Yes	0	5	4
155	R:R:L230	R:R:P231	4.93	No	No	0	5	4
156	R:R:E232	R:R:L234	6.63	No	No	0	1	5
157	R:R:E232	R:R:L235	5.3	No	No	0	1	4
158	R:R:I314	R:R:V236	7.68	Yes	No	0	2	3
159	R:R:G237	R:R:K315	3.49	No	No	0	1	2
160	R:R:M239	R:R:Y311	5.99	No	No	0	4	5
161	R:R:F240	R:R:N241	4.83	Yes	No	0	3	3
162	R:R:F240	R:R:V308	3.93	Yes	No	0	3	6
163	R:R:F240	R:R:F312	6.43	Yes	No	0	3	3
164	R:R:F240	R:R:K315	7.44	Yes	No	0	3	2
165	R:R:F243	R:R:Y242	12.38	Yes	Yes	0	6	5
166	R:R:L246	R:R:Y242	7.03	No	Yes	0	5	5
167	R:R:F243	R:R:L307	15.83	Yes	No	0	6	5
168	R:R:F243	R:R:Y311	10.32	Yes	No	0	6	5
169	R:R:G249	R:R:I248	3.53	No	No	0	5	4
170	R:R:F251	R:R:L252	4.87	No	No	0	8	4
171	R:R:F251	R:R:T301	5.19	No	No	0	8	5
172	R:R:F251	R:R:N304	16.92	No	No	0	8	8
173	R:R:F253	R:R:P254	4.33	No	Yes	0	6	9
174	R:R:F253	R:R:L257	10.96	No	No	0	6	7
175	R:R:A255	R:R:Y296	4	No	No	0	7	9
176	R:R:T258	R:R:Y296	8.74	No	No	0	8	9
177	R:R:M265	R:R:Y262	4.79	No	Yes	0	8	9
178	R:R:L288	R:R:Y262	9.38	No	Yes	0	8	9
179	R:R:A289	R:R:Y262	4	No	Yes	0	8	9
180	R:R:V292	R:R:Y262	7.57	No	Yes	0	8	9
181	R:R:R267	R:R:V263	6.54	No	No	0	4	3
182	R:R:K281	R:R:L269	4.23	No	No	0	5	8
183	R:R:E279	R:R:R282	4.65	No	No	0	3	6
184	R:R:E279	R:R:K283	6.75	No	No	0	3	5
185	R:R:K280	R:R:R284	12.38	No	No	0	4	7
186	R:R:I286	R:R:R282	5.01	No	No	0	6	6
187	R:R:R284	R:R:R352	19.19	No	No	0	7	8
188	R:R:F346	R:R:K287	7.44	Yes	No	0	7	5
189	R:R:F346	R:R:L288	3.65	Yes	No	0	7	8
190	R:R:F346	R:R:T291	3.89	Yes	No	0	7	5
191	R:R:F300	R:R:M295	8.71	Yes	Yes	0	9	6
192	R:R:I339	R:R:M295	4.37	No	Yes	0	6	6
193	R:R:D340	R:R:M295	4.16	Yes	Yes	0	9	6
194	R:R:F300	R:R:Y296	15.47	Yes	No	0	9	9
195	R:R:S303	R:R:S333	4.89	No	No	7	7	8
196	R:R:L306	R:R:V322	4.47	No	No	0	4	4
197	R:R:L307	R:R:Y326	5.86	No	Yes	0	5	4
198	R:R:V309	R:R:V322	4.81	No	No	0	4	4
199	R:R:H310	R:R:Y311	6.53	Yes	No	0	4	5
200	R:R:H310	R:R:I314	9.28	Yes	Yes	8	4	2
201	R:R:H310	R:R:S320	8.37	Yes	No	8	4	2
202	R:R:H310	R:R:Y323	7.62	Yes	Yes	0	4	4
203	R:R:H310	R:R:Y326	26.13	Yes	Yes	0	4	4
204	R:R:L313	R:R:S320	4.5	Yes	No	0	1	2
205	R:R:H321	R:R:L313	3.86	No	Yes	0	4	1
206	R:R:I314	R:R:S320	4.64	Yes	No	8	2	2
207	R:R:Q317	R:R:S316	4.33	No	No	0	1	1
208	R:R:H321	R:R:V322	5.54	No	No	0	4	4
209	R:R:I327	R:R:Y323	7.25	No	Yes	0	4	4
210	R:R:L330	R:R:Y326	9.38	No	Yes	0	5	4
211	R:R:D340	R:R:N336	4.04	Yes	No	2	9	9
212	R:R:D340	R:R:Y344	6.9	Yes	Yes	2	9	9
213	R:R:F351	R:R:Y344	8.25	No	Yes	0	8	9
214	R:R:F346	R:R:Y345	7.22	Yes	Yes	0	7	7
215	R:R:R352	R:R:Y345	7.2	No	Yes	0	8	7
216	R:R:K356	R:R:Y345	7.17	No	Yes	0	4	7
217	R:R:H349	R:R:R352	7.9	No	No	0	5	8
218	R:R:C299	R:R:I298	3.27	No	No	0	9	6
219	R:R:A191	R:R:I112	3.25	No	No	0	8	6
220	R:R:C299	R:R:M295	3.24	No	Yes	0	9	6
221	R:R:S65	R:R:V61	3.23	No	No	0	5	6
222	R:R:S337	R:R:V125	3.23	No	No	0	9	6
223	R:R:A174	R:R:M265	3.22	No	No	0	8	8
224	R:R:V229	R:R:V61	3.21	No	No	0	4	6
225	R:R:A66	R:R:L221	3.15	No	Yes	0	4	3
226	R:R:A118	R:R:L97	3.15	No	No	0	8	7
227	R:R:T74	R:R:T75	3.14	No	No	0	4	5
228	R:R:A120	R:R:N158	3.13	No	Yes	0	8	8
229	R:R:A247	R:R:N304	3.13	No	No	0	5	8
230	R:R:M159	R:R:S303	3.07	No	No	7	7	7
231	R:R:M159	R:R:S333	3.07	No	No	7	7	8
232	R:R:I202	R:R:V205	3.07	No	No	0	8	5
233	R:R:I207	R:R:V211	3.07	No	No	0	4	3
234	R:R:K72	R:R:T75	3	No	No	0	2	5
235	R:R:L313	R:R:S316	3	Yes	No	0	1	1
236	R:R:L73	R:R:V328	2.98	No	No	0	3	6
237	R:R:N93	R:R:S92	2.98	Yes	No	0	9	7
238	R:R:L244	R:R:V308	2.98	No	No	0	5	6
239	R:R:L288	R:R:V343	2.98	No	No	0	8	8
240	R:R:L332	R:R:V328	2.98	No	No	0	8	6
241	R:R:L209	R:R:T206	2.95	No	No	0	4	7
242	R:R:I132	R:R:I136	2.94	No	No	0	7	4
243	R:R:I190	R:R:I194	2.94	No	No	0	4	5
244	R:R:I194	R:R:I198	2.94	No	No	0	5	7
245	R:R:I248	R:R:L244	2.85	No	No	0	4	5
246	R:R:G144	R:R:W141	2.81	No	Yes	0	8	9
247	R:R:L122	R:R:L97	2.77	No	No	0	8	7
248	R:R:A115	R:R:F100	2.77	No	Yes	0	7	6
249	R:R:L306	R:R:L325	2.77	No	No	0	4	5
250	R:R:A355	R:R:Y345	2.67	No	Yes	0	7	7
251	R:R:H137	R:R:I136	2.65	No	No	0	4	4
252	R:R:D62	R:R:Q319	2.61	No	No	0	7	4
253	R:R:F342	R:R:T291	2.59	No	No	0	6	5
254	R:R:F300	R:R:L166	2.44	Yes	No	0	9	8
255	R:R:F256	R:R:L257	2.44	No	No	0	3	7
256	R:R:F312	R:R:L313	2.44	No	Yes	0	3	1
257	R:R:D62	R:R:F64	2.39	No	No	0	7	2
258	R:R:L203	R:R:Y210	2.34	No	No	0	3	5
259	R:R:N179	R:R:W175	2.26	No	No	0	6	5
260	R:R:A108	R:R:P109	1.87	No	No	0	7	7
261	R:R:A329	R:R:P302	1.87	No	No	0	7	9
262	R:R:G138	R:R:T75	1.82	No	No	0	4	5
263	R:R:A174	R:R:A261	1.79	No	No	0	8	7
264	R:R:G193	R:R:I192	1.76	No	No	0	2	3
265	R:R:G318	R:R:I314	1.76	No	Yes	0	1	2
266	R:R:G182	R:R:M181	1.75	No	No	0	4	5
267	R:R:P302	R:R:T301	1.75	No	No	0	9	5
268	R:R:A220	R:R:S60	1.71	No	No	0	1	7
269	R:R:G193	R:R:L196	1.71	No	No	0	2	5
270	R:R:A324	R:R:V68	1.7	No	No	0	1	4
271	R:R:A110	R:R:V347	1.7	No	No	0	8	7
272	R:R:A261	R:R:V171	1.7	No	No	0	7	6
273	R:R:N179	R:R:P180	1.63	No	No	0	6	8
274	R:R:S67	R:R:V68	1.62	No	No	0	4	4
275	R:R:A188	R:R:I112	1.62	No	No	0	3	6
276	R:R:A157	R:R:I202	1.62	No	No	0	5	8
277	R:R:A268	R:R:I177	1.62	No	No	0	5	8
278	R:R:A289	R:R:I266	1.62	No	No	0	8	5
279	R:R:A285	R:R:M265	1.61	No	No	0	7	8
280	R:R:V211	R:R:V212	1.6	No	No	0	3	4
281	R:R:T83	R:R:V87	1.59	No	No	0	5	5
282	R:R:G182	R:R:H183	1.59	No	No	0	4	6
283	R:R:C299	R:R:L335	1.59	No	No	0	9	5
284	R:R:I80	R:R:V76	1.54	No	No	0	5	4
285	R:R:I84	R:R:V88	1.54	No	No	0	5	6
286	R:R:I286	R:R:V290	1.54	No	No	0	6	5
287	R:R:N158	R:R:S124	1.49	Yes	No	0	8	7
288	R:R:L264	R:R:V178	1.49	No	No	0	4	7
289	R:R:L235	R:R:V212	1.49	No	No	0	4	4
290	R:R:L305	R:R:V309	1.49	No	No	0	6	4
291	R:R:L221	R:R:T70	1.47	Yes	No	0	3	7
292	R:R:K283	R:R:K287	1.44	No	No	0	5	5
293	R:R:I126	R:R:L90	1.43	No	Yes	0	5	6
294	R:R:Q233	R:R:V236	1.43	No	No	0	1	3
295	R:R:I298	R:R:L297	1.43	No	No	0	6	5
296	R:R:K280	R:R:N277	1.4	No	No	0	4	4
297	R:R:D238	R:R:L235	1.36	No	No	0	2	4
298	R:R:A133	R:R:Y143	1.33	No	Yes	0	4	7
299	R:R:D353	R:R:H354	1.26	No	Yes	0	4	5
300	R:R:M181	R:R:W175	1.16	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y82	7.96167	6	1	7
2	R:R:L90	3.5125	4	5	6
3	R:R:N93	7.365	4	2	9
4	R:R:F100	5.538	5	2	6
5	R:R:Y113	6.715	4	0	7
6	R:R:M114	6.95	4	2	8
7	R:R:D121	7.768	5	2	9
8	R:R:W127	5.6325	4	0	7
9	R:R:F128	7.0325	4	1	8
10	R:R:Y134	7.492	5	1	5
11	R:R:H135	7.042	5	1	5
12	R:R:N139	7.325	4	1	5
13	R:R:W141	6.98667	6	1	9
14	R:R:Y143	6.5625	4	0	7
15	R:R:Y156	8.8	4	0	5
16	R:R:N158	5.104	5	2	8
17	R:R:Y160	7.4725	4	0	7
18	R:R:F165	8.094	5	3	7
19	R:R:Q172	8.19	4	6	8
20	R:R:W199	5.48	4	3	9
21	R:R:L221	4.7225	4	0	3
22	R:R:F240	5.6575	4	0	3
23	R:R:Y242	9.2275	4	0	5
24	R:R:F243	11.695	4	0	6
25	R:R:P254	4.0625	4	0	9
26	R:R:Y262	7.182	5	0	9
27	R:R:M295	5.12	4	0	6
28	R:R:F300	9.48	4	0	9
29	R:R:H310	11.586	5	8	4
30	R:R:L313	3.45	4	0	1
31	R:R:I314	5.84	4	8	2
32	R:R:Y323	6.464	5	0	4
33	R:R:Y326	11.4325	4	0	4
34	R:R:D340	7.05	5	2	9
35	R:R:Y344	6.79875	8	2	9
36	R:R:Y345	6.065	4	0	7
37	R:R:F346	5.55	4	0	7
38	R:R:H354	6.9275	4	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S65	R:R:V61	20.3612	3.23	No	No	0	5	6
2	R:R:V229	R:R:V61	18.9708	3.21	No	No	0	4	6
3	R:R:T225	R:R:V229	17.5705	9.52	No	No	0	4	4
4	R:R:I218	R:R:T225	16.1603	4.56	No	No	0	4	4
5	R:R:S65	R:R:Y323	25.6606	6.36	No	Yes	0	5	4
6	R:R:L69	R:R:Y323	28.8323	3.52	No	Yes	0	4	4
7	R:R:L69	R:R:N139	28.2039	6.87	No	Yes	0	4	5
8	R:R:I327	R:R:Y323	22.9837	7.25	No	Yes	0	4	4
9	R:R:I327	R:R:L78	22.2712	4.28	No	No	0	4	5
10	R:R:L78	R:R:Y82	14.1267	4.69	No	Yes	1	5	7
11	R:R:H135	R:R:P79	17.7783	4.58	Yes	No	0	5	5
12	R:R:I136	R:R:P79	14.8392	5.08	No	No	0	4	5
13	R:R:H310	R:R:Y323	66.5364	7.62	Yes	Yes	0	4	4
14	R:R:H310	R:R:Y311	70.6927	6.53	Yes	No	0	4	5
15	R:R:F243	R:R:Y311	71.1677	10.32	Yes	No	0	6	5
16	R:R:F243	R:R:Y242	76.0663	12.38	Yes	Yes	0	6	5
17	R:R:L246	R:R:Y242	83.4438	7.03	No	Yes	0	5	5
18	R:R:L246	R:R:Y160	83.5181	10.55	No	Yes	0	5	7
19	R:R:V250	R:R:Y160	83.7902	6.31	No	Yes	0	5	7
20	R:R:L164	R:R:V250	83.9238	4.47	No	No	0	6	5
21	R:R:L164	R:R:P254	100	3.28	No	Yes	0	6	9
22	R:R:I163	R:R:P254	94.6759	3.39	No	Yes	0	7	9
23	R:R:F300	R:R:I163	94.1613	11.3	Yes	No	0	9	7
24	R:R:F300	R:R:M295	92.8451	8.71	Yes	Yes	0	9	6
25	R:R:D340	R:R:M295	89.2528	4.16	Yes	Yes	0	9	6
26	R:R:D121	R:R:D340	15.997	10.65	Yes	Yes	2	9	9
27	R:R:D121	R:R:S337	11.8308	5.89	Yes	No	0	9	9
28	R:R:D340	R:R:Y344	66.9223	6.9	Yes	Yes	2	9	9
29	R:R:A118	R:R:Y344	16.3731	4	No	Yes	2	8	9
30	R:R:A118	R:R:L97	15.9772	3.15	No	No	0	8	7
31	R:R:L101	R:R:L97	11.6972	5.54	No	No	0	4	7
32	R:R:F102	R:R:L101	10.2524	8.53	No	No	0	4	4
33	R:R:F100	R:R:Y344	43.6764	8.25	Yes	Yes	2	6	9
34	R:R:F100	R:R:V111	41.9891	3.93	Yes	No	0	6	7
35	R:R:M114	R:R:Y344	10.4849	7.18	Yes	Yes	2	8	9
36	R:R:T104	R:R:V111	40.856	7.93	No	No	0	6	7
37	R:R:D350	R:R:T104	39.713	7.23	No	No	0	6	6
38	R:R:D350	R:R:K106	38.5552	9.68	No	No	0	6	7
39	R:R:H349	R:R:K106	37.3676	5.24	No	No	0	5	7
40	R:R:I198	R:R:L164	48.5849	4.28	No	No	0	7	6
41	R:R:I194	R:R:I198	30.6136	2.94	No	No	0	5	7
42	R:R:I194	R:R:Y113	28.1989	6.04	No	Yes	0	5	7
43	R:R:Q172	R:R:Y113	18.3078	3.38	Yes	Yes	0	8	7
44	R:R:K187	R:R:Q172	13.147	8.14	No	Yes	6	6	8
45	R:R:F165	R:R:I198	31.5141	11.3	Yes	No	0	7	7
46	R:R:N139	R:R:Y134	16.2494	5.81	Yes	Yes	1	5	5
47	R:R:W141	R:R:Y134	22.3404	8.68	Yes	Yes	1	9	5
48	R:R:L151	R:R:W141	24.2652	4.56	No	Yes	0	5	9
49	R:R:L151	R:R:W127	24.4631	7.97	No	Yes	0	5	7
50	R:R:F154	R:R:W127	24.7353	5.01	No	Yes	0	5	7
51	R:R:F154	R:R:L123	25.0272	6.09	No	No	0	5	7
52	R:R:L119	R:R:L123	25.3538	6.92	No	No	0	6	7
53	R:R:L119	R:R:W199	25.7793	3.42	No	Yes	0	6	9
54	R:R:C148	R:R:T215	12.2266	3.38	No	No	1	9	4
55	R:R:L209	R:R:Y156	11.2172	5.86	No	Yes	0	4	5
56	R:R:L209	R:R:T206	10.1682	2.95	No	No	0	4	7
57	R:R:L209	R:R:Y242	12.2563	10.55	No	Yes	0	4	5
58	R:R:N304	R:R:Y160	10.1435	4.65	No	Yes	0	8	7
59	R:R:H349	R:R:R352	36.1999	7.9	No	No	0	5	8
60	R:R:R352	R:R:Y345	31.5438	7.2	No	Yes	0	8	7
61	R:R:F346	R:R:Y345	27.808	7.22	Yes	Yes	0	7	7
62	R:R:F346	R:R:L288	16.3978	3.65	Yes	No	0	7	8
63	R:R:L288	R:R:Y262	13.8743	9.38	No	Yes	0	8	9
64	R:R:K187	R:R:M181	12.0683	4.32	No	No	0	6	5
65	R:R:P208	R:R:Y242	11.2815	6.95	No	Yes	0	7	5
66	R:R:I207	R:R:P208	10.0148	3.39	No	No	0	4	7
67	R:R:H310	R:R:S320	26.3187	8.37	Yes	No	8	4	2
68	R:R:L313	R:R:S320	25.3785	4.5	Yes	No	0	1	2
69	R:R:F312	R:R:L313	13.0876	2.44	No	Yes	0	3	1
70	R:R:F240	R:R:F312	11.6724	6.43	Yes	No	0	3	3
71	R:R:F165	R:R:W199	24.29	5.01	Yes	Yes	3	7	9
72	R:R:H135	R:R:Y134	10.8016	10.89	Yes	Yes	1	5	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 5NJ6

PDB Summary
PDB	5NJ6
Class	A
SubFamily	Peptide
Type	Proteinase-activated
SubType	PAR2
Species	Homo sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	4
Date	2017-05-03
D.O.I.	10.1038/nature22309

Net Summary
I_min	3.28
Number of Linked Nodes	273
Number of Links	300
Number of Hubs	38
Number of Links mediated by Hubs	144
Number of Communities	8
Number of Nodes involved in Communities	46
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	42875
Length Of Smallest Path	3
Average Path Length	15.8953
Length of Longest Path	39
Minimum Path Strength	1.425
Average Path Strength	6.45138
Maximum Path Strength	17.755
Minimum Path Correlation	0.7
Average Path Correlation	0.927527
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	46.9027
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.7858
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P55085
Sequence	>5NJ6_Chain_R F S V D E F S A S V L T G K L T T V F L P I V Y T I V F V V A L P S N G M A L W V F L F R T K K K A P A V I Y M A N L A L A D L L S V I W F P L K I A Y H I H G N N W I Y G E A L C N V L I G F F Y A N M Y C S I L F L T C L S V Q R A W E I V N P M G H S R K K A N I A I G I S L A I W L L I L L V T I P L Y V V K Q T I F I P A L Q I T T C H D V L P E Q L L V G D M F N Y F L S L A I G V F L F P A F L T A S A Y V L M I R A L E N S E K K R K R A I K L A V T V A A M Y L I C F T P S N L L L V V H Y F L I K S Q G Q S H V Y A L Y I V A L C L S T L N S C I D P F V Y Y F V S H D F R D H A K N A L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5NDD	A	Peptide	Proteinase-activated	PAR2	Homo sapiens	-	AZ8838; Na	-	2.8	2017-05-03	10.1038/nature22309
	5NDZ	A	Peptide	Proteinase-activated	PAR2	Homo sapiens	-	AZ3451; Na	-	3.6	2017-05-03	10.1038/nature22309
	5NJ6	A	Peptide	Proteinase-activated	PAR2	Homo sapiens	-	-	-	4	2017-05-03	10.1038/nature22309

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 5NJ6.zip

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