psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F59	R:R:P219	7.22	No	No	0	7	1
2	R:R:D62	R:R:S65	10.31	No	No	0	7	5
3	R:R:S65	R:R:Y323	6.36	No	Yes	0	5	4
4	R:R:V68	R:R:Y323	7.57	No	Yes	0	4	4
5	R:R:L69	R:R:N139	6.87	No	Yes	0	4	5
6	R:R:L69	R:R:Y323	3.52	No	Yes	0	4	4
7	R:R:K72	R:R:V76	4.55	No	No	0	2	4
8	R:R:F77	R:R:L73	3.65	No	No	0	4	3
9	R:R:N139	R:R:T74	10.24	Yes	No	0	5	4
10	R:R:F77	R:R:V81	6.55	No	No	0	4	6
11	R:R:L78	R:R:Y82	4.69	No	Yes	1	5	7
12	R:R:H135	R:R:L78	9	Yes	No	1	5	5
13	R:R:I327	R:R:L78	4.28	No	No	0	4	5
14	R:R:H135	R:R:P79	4.58	Yes	No	0	5	5
15	R:R:I136	R:R:P79	5.08	No	No	0	4	5
16	R:R:C331	R:R:V81	5.12	No	No	0	6	6
17	R:R:F128	R:R:Y82	5.16	Yes	Yes	1	8	7
18	R:R:K131	R:R:Y82	17.91	No	Yes	1	7	7
19	R:R:H135	R:R:Y82	4.36	Yes	Yes	1	5	7
20	R:R:C331	R:R:Y82	9.41	No	Yes	0	6	7
21	R:R:T334	R:R:Y82	6.24	No	Yes	1	7	7
22	R:R:I132	R:R:T83	7.6	No	No	0	7	5
23	R:R:F128	R:R:V85	6.55	Yes	No	0	8	8
24	R:R:C338	R:R:V85	5.12	No	No	0	7	8
25	R:R:F86	R:R:L90	4.87	No	Yes	5	6	6
26	R:R:F86	R:R:V125	5.24	No	No	5	6	6
27	R:R:F86	R:R:P129	8.67	No	No	0	6	8
28	R:R:C338	R:R:V88	5.12	No	No	0	7	6
29	R:R:A89	R:R:S337	3.42	No	No	0	8	9
30	R:R:L90	R:R:P91	3.28	Yes	No	0	6	5
31	R:R:L90	R:R:V125	4.47	Yes	No	5	6	6
32	R:R:P341	R:R:S92	7.13	No	No	0	9	7
33	R:R:A118	R:R:N93	4.69	No	Yes	2	8	9
34	R:R:D121	R:R:N93	14.81	Yes	Yes	2	9	9
35	R:R:N93	R:R:Y344	6.98	Yes	Yes	2	9	9
36	R:R:G94	R:R:L122	3.42	No	No	0	4	8
37	R:R:F351	R:R:M95	3.73	No	No	0	8	6
38	R:R:A96	R:R:F351	4.16	No	No	0	9	8
39	R:R:L101	R:R:L97	5.54	No	No	0	4	7
40	R:R:F102	R:R:W98	8.02	No	No	0	4	3
41	R:R:R103	R:R:W98	16.99	No	No	4	5	3
42	R:R:H354	R:R:W98	6.35	Yes	No	4	5	3
43	R:R:R103	R:R:V99	3.92	No	No	4	5	8
44	R:R:H354	R:R:V99	11.07	Yes	No	4	5	8
45	R:R:F100	R:R:V111	3.93	Yes	No	0	6	7
46	R:R:F100	R:R:M114	7.46	Yes	Yes	2	6	8
47	R:R:F100	R:R:Y344	8.25	Yes	Yes	2	6	9
48	R:R:F100	R:R:S348	5.28	Yes	No	0	6	8
49	R:R:F102	R:R:L101	8.53	No	No	0	4	4
50	R:R:H354	R:R:R103	9.03	Yes	No	4	5	5
51	R:R:T104	R:R:V111	7.93	No	No	0	6	7
52	R:R:D350	R:R:T104	7.23	No	No	0	6	6
53	R:R:H349	R:R:K106	5.24	No	No	0	5	7
54	R:R:D350	R:R:K106	9.68	No	No	0	6	7
55	R:R:P109	R:R:Q172	11.05	No	Yes	6	7	8
56	R:R:K187	R:R:P109	3.35	No	No	6	6	7
57	R:R:I112	R:R:I192	5.89	No	No	0	6	3
58	R:R:C168	R:R:Y113	12.1	No	Yes	0	7	7
59	R:R:Q172	R:R:Y113	3.38	Yes	Yes	0	8	7
60	R:R:A191	R:R:Y113	5.34	No	Yes	0	8	7
61	R:R:I194	R:R:Y113	6.04	No	Yes	0	5	7
62	R:R:L169	R:R:M114	7.07	No	Yes	0	8	8
63	R:R:M114	R:R:Y344	7.18	Yes	Yes	2	8	9
64	R:R:M114	R:R:V347	6.09	Yes	No	0	8	7
65	R:R:F165	R:R:N116	13.29	Yes	No	3	7	9
66	R:R:N116	R:R:S195	7.45	No	No	3	9	7
67	R:R:N116	R:R:W199	5.65	No	Yes	3	9	9
68	R:R:D340	R:R:L117	9.5	Yes	No	2	9	9
69	R:R:L117	R:R:Y344	9.38	No	Yes	2	9	9
70	R:R:A118	R:R:Y344	4	No	Yes	2	8	9
71	R:R:L119	R:R:L123	6.92	No	No	0	6	7
72	R:R:L119	R:R:W199	3.42	No	Yes	0	6	9
73	R:R:D121	R:R:N158	4.04	Yes	Yes	2	9	8
74	R:R:D121	R:R:S337	5.89	Yes	No	0	9	9
75	R:R:D121	R:R:D340	10.65	Yes	Yes	2	9	9
76	R:R:D121	R:R:Y344	3.45	Yes	Yes	2	9	9
77	R:R:F154	R:R:L123	6.09	No	No	0	5	7
78	R:R:L147	R:R:W127	3.42	No	Yes	0	6	7
79	R:R:V150	R:R:W127	6.13	No	Yes	0	5	7
80	R:R:L151	R:R:W127	7.97	No	Yes	0	5	7
81	R:R:F154	R:R:W127	5.01	No	Yes	0	5	7
82	R:R:F128	R:R:K131	9.93	Yes	No	1	8	7
83	R:R:F128	R:R:T334	6.49	Yes	No	1	8	7
84	R:R:L130	R:R:Y143	5.86	No	Yes	0	7	7
85	R:R:H135	R:R:Y134	10.89	Yes	Yes	1	5	5
86	R:R:N139	R:R:Y134	5.81	Yes	Yes	1	5	5
87	R:R:W141	R:R:Y134	8.68	Yes	Yes	1	9	5
88	R:R:C226	R:R:Y134	4.03	No	Yes	1	9	5
89	R:R:D228	R:R:Y134	8.05	No	Yes	0	4	5
90	R:R:H135	R:R:N139	6.38	Yes	Yes	1	5	5
91	R:R:I223	R:R:N140	8.5	No	No	0	3	4
92	R:R:W141	R:R:Y143	15.43	Yes	Yes	0	9	7
93	R:R:C148	R:R:W141	5.22	No	Yes	1	9	9
94	R:R:L151	R:R:W141	4.56	No	Yes	0	5	9
95	R:R:C226	R:R:W141	5.22	No	Yes	1	9	9
96	R:R:I142	R:R:Y143	3.63	No	Yes	0	1	7
97	R:R:E145	R:R:K213	10.8	No	No	1	3	5
98	R:R:E145	R:R:T215	8.47	No	No	1	3	4
99	R:R:C148	R:R:T215	3.38	No	No	1	9	4
100	R:R:C148	R:R:C226	7.28	No	No	1	9	9
101	R:R:N149	R:R:Q214	6.6	No	No	0	6	4
102	R:R:I152	R:R:Q214	5.49	No	No	0	5	4
103	R:R:H227	R:R:I152	9.28	No	No	0	5	5
104	R:R:G153	R:R:Y210	5.79	No	No	0	6	5
105	R:R:F155	R:R:Y156	12.38	No	Yes	0	6	5
106	R:R:F155	R:R:L330	3.65	No	No	0	6	5
107	R:R:L209	R:R:Y156	5.86	No	Yes	0	4	5
108	R:R:H227	R:R:Y156	8.71	No	Yes	0	5	5
109	R:R:F243	R:R:Y156	8.25	Yes	Yes	0	6	5
110	R:R:N158	R:R:S162	5.96	Yes	No	2	8	9
111	R:R:N158	R:R:N336	10.9	Yes	No	2	8	9
112	R:R:M159	R:R:Y160	8.38	No	Yes	0	7	7
113	R:R:L246	R:R:Y160	10.55	No	Yes	0	5	7
114	R:R:V250	R:R:Y160	6.31	No	Yes	0	5	7
115	R:R:N304	R:R:Y160	4.65	No	Yes	0	8	7
116	R:R:C161	R:R:F165	5.59	No	Yes	3	7	7
117	R:R:C161	R:R:W199	7.84	No	Yes	3	7	9
118	R:R:C161	R:R:I202	4.91	No	No	0	7	8
119	R:R:N336	R:R:S162	4.47	No	No	2	9	9
120	R:R:I163	R:R:P254	3.39	No	Yes	0	7	9
121	R:R:F300	R:R:I163	11.3	Yes	No	0	9	7
122	R:R:I198	R:R:L164	4.28	No	No	0	7	6
123	R:R:L164	R:R:V250	4.47	No	No	0	6	5
124	R:R:L164	R:R:P254	3.28	No	Yes	0	6	9
125	R:R:F165	R:R:S195	5.28	Yes	No	3	7	7
126	R:R:F165	R:R:I198	11.3	Yes	No	0	7	7
127	R:R:F165	R:R:W199	5.01	Yes	Yes	3	7	9
128	R:R:P254	R:R:T167	5.25	Yes	No	0	9	7
129	R:R:T167	R:R:T258	6.28	No	No	0	7	8
130	R:R:S170	R:R:Y262	10.17	No	Yes	0	9	9
131	R:R:E176	R:R:Q172	10.19	No	Yes	0	8	8
132	R:R:K187	R:R:Q172	8.14	No	Yes	6	6	8
133	R:R:K281	R:R:R173	3.71	No	No	0	5	9
134	R:R:R173	R:R:V347	9.15	No	No	0	9	7
135	R:R:I177	R:R:L269	5.71	No	No	0	8	8
136	R:R:N179	R:R:V178	4.43	No	No	0	6	7
137	R:R:K187	R:R:M181	4.32	No	No	0	6	5
138	R:R:H183	R:R:K186	7.86	No	No	0	6	7
139	R:R:T206	R:R:Y210	6.24	No	No	0	7	5
140	R:R:I207	R:R:P208	3.39	No	No	0	4	7
141	R:R:P208	R:R:Y242	6.95	No	Yes	0	7	5
142	R:R:L209	R:R:Y242	10.55	No	Yes	0	4	5
143	R:R:K213	R:R:T215	6.01	No	No	1	5	4
144	R:R:K213	R:R:P231	3.35	No	No	0	5	4
145	R:R:I216	R:R:P231	6.77	No	No	0	1	4
146	R:R:F217	R:R:P219	7.22	No	No	0	1	1
147	R:R:F217	R:R:Q222	3.51	No	No	0	1	5
148	R:R:F217	R:R:T224	5.19	No	No	0	1	5
149	R:R:I218	R:R:P219	3.39	No	No	0	4	1
150	R:R:I218	R:R:L221	8.56	No	Yes	0	4	3
151	R:R:I218	R:R:T225	4.56	No	No	0	4	4
152	R:R:I223	R:R:L221	5.71	No	Yes	0	3	3
153	R:R:T225	R:R:V229	9.52	No	No	0	4	4
154	R:R:H227	R:R:Y326	4.36	No	Yes	0	5	4
155	R:R:L230	R:R:P231	4.93	No	No	0	5	4
156	R:R:E232	R:R:L234	6.63	No	No	0	1	5
157	R:R:E232	R:R:L235	5.3	No	No	0	1	4
158	R:R:I314	R:R:V236	7.68	Yes	No	0	2	3
159	R:R:G237	R:R:K315	3.49	No	No	0	1	2
160	R:R:M239	R:R:Y311	5.99	No	No	0	4	5
161	R:R:F240	R:R:N241	4.83	Yes	No	0	3	3
162	R:R:F240	R:R:V308	3.93	Yes	No	0	3	6
163	R:R:F240	R:R:F312	6.43	Yes	No	0	3	3
164	R:R:F240	R:R:K315	7.44	Yes	No	0	3	2
165	R:R:F243	R:R:Y242	12.38	Yes	Yes	0	6	5
166	R:R:L246	R:R:Y242	7.03	No	Yes	0	5	5
167	R:R:F243	R:R:L307	15.83	Yes	No	0	6	5
168	R:R:F243	R:R:Y311	10.32	Yes	No	0	6	5
169	R:R:G249	R:R:I248	3.53	No	No	0	5	4
170	R:R:F251	R:R:L252	4.87	No	No	0	8	4
171	R:R:F251	R:R:T301	5.19	No	No	0	8	5
172	R:R:F251	R:R:N304	16.92	No	No	0	8	8
173	R:R:F253	R:R:P254	4.33	No	Yes	0	6	9
174	R:R:F253	R:R:L257	10.96	No	No	0	6	7
175	R:R:A255	R:R:Y296	4	No	No	0	7	9
176	R:R:T258	R:R:Y296	8.74	No	No	0	8	9
177	R:R:M265	R:R:Y262	4.79	No	Yes	0	8	9
178	R:R:L288	R:R:Y262	9.38	No	Yes	0	8	9
179	R:R:A289	R:R:Y262	4	No	Yes	0	8	9
180	R:R:V292	R:R:Y262	7.57	No	Yes	0	8	9
181	R:R:R267	R:R:V263	6.54	No	No	0	4	3
182	R:R:K281	R:R:L269	4.23	No	No	0	5	8
183	R:R:E279	R:R:R282	4.65	No	No	0	3	6
184	R:R:E279	R:R:K283	6.75	No	No	0	3	5
185	R:R:K280	R:R:R284	12.38	No	No	0	4	7
186	R:R:I286	R:R:R282	5.01	No	No	0	6	6
187	R:R:R284	R:R:R352	19.19	No	No	0	7	8
188	R:R:F346	R:R:K287	7.44	Yes	No	0	7	5
189	R:R:F346	R:R:L288	3.65	Yes	No	0	7	8
190	R:R:F346	R:R:T291	3.89	Yes	No	0	7	5
191	R:R:F300	R:R:M295	8.71	Yes	Yes	0	9	6
192	R:R:I339	R:R:M295	4.37	No	Yes	0	6	6
193	R:R:D340	R:R:M295	4.16	Yes	Yes	0	9	6
194	R:R:F300	R:R:Y296	15.47	Yes	No	0	9	9
195	R:R:S303	R:R:S333	4.89	No	No	7	7	8
196	R:R:L306	R:R:V322	4.47	No	No	0	4	4
197	R:R:L307	R:R:Y326	5.86	No	Yes	0	5	4
198	R:R:V309	R:R:V322	4.81	No	No	0	4	4
199	R:R:H310	R:R:Y311	6.53	Yes	No	0	4	5
200	R:R:H310	R:R:I314	9.28	Yes	Yes	8	4	2
201	R:R:H310	R:R:S320	8.37	Yes	No	8	4	2
202	R:R:H310	R:R:Y323	7.62	Yes	Yes	0	4	4
203	R:R:H310	R:R:Y326	26.13	Yes	Yes	0	4	4
204	R:R:L313	R:R:S320	4.5	Yes	No	0	1	2
205	R:R:H321	R:R:L313	3.86	No	Yes	0	4	1
206	R:R:I314	R:R:S320	4.64	Yes	No	8	2	2
207	R:R:Q317	R:R:S316	4.33	No	No	0	1	1
208	R:R:H321	R:R:V322	5.54	No	No	0	4	4
209	R:R:I327	R:R:Y323	7.25	No	Yes	0	4	4
210	R:R:L330	R:R:Y326	9.38	No	Yes	0	5	4
211	R:R:D340	R:R:N336	4.04	Yes	No	2	9	9
212	R:R:D340	R:R:Y344	6.9	Yes	Yes	2	9	9
213	R:R:F351	R:R:Y344	8.25	No	Yes	0	8	9
214	R:R:F346	R:R:Y345	7.22	Yes	Yes	0	7	7
215	R:R:R352	R:R:Y345	7.2	No	Yes	0	8	7
216	R:R:K356	R:R:Y345	7.17	No	Yes	0	4	7
217	R:R:H349	R:R:R352	7.9	No	No	0	5	8
218	R:R:C299	R:R:I298	3.27	No	No	0	9	6
219	R:R:A191	R:R:I112	3.25	No	No	0	8	6
220	R:R:C299	R:R:M295	3.24	No	Yes	0	9	6
221	R:R:S65	R:R:V61	3.23	No	No	0	5	6
222	R:R:S337	R:R:V125	3.23	No	No	0	9	6
223	R:R:A174	R:R:M265	3.22	No	No	0	8	8
224	R:R:V229	R:R:V61	3.21	No	No	0	4	6
225	R:R:A66	R:R:L221	3.15	No	Yes	0	4	3
226	R:R:A118	R:R:L97	3.15	No	No	0	8	7
227	R:R:T74	R:R:T75	3.14	No	No	0	4	5
228	R:R:A120	R:R:N158	3.13	No	Yes	0	8	8
229	R:R:A247	R:R:N304	3.13	No	No	0	5	8
230	R:R:M159	R:R:S303	3.07	No	No	7	7	7
231	R:R:M159	R:R:S333	3.07	No	No	7	7	8
232	R:R:I202	R:R:V205	3.07	No	No	0	8	5
233	R:R:I207	R:R:V211	3.07	No	No	0	4	3
234	R:R:K72	R:R:T75	3	No	No	0	2	5
235	R:R:L313	R:R:S316	3	Yes	No	0	1	1
236	R:R:L73	R:R:V328	2.98	No	No	0	3	6
237	R:R:N93	R:R:S92	2.98	Yes	No	0	9	7
238	R:R:L244	R:R:V308	2.98	No	No	0	5	6
239	R:R:L288	R:R:V343	2.98	No	No	0	8	8
240	R:R:L332	R:R:V328	2.98	No	No	0	8	6
241	R:R:L209	R:R:T206	2.95	No	No	0	4	7
242	R:R:I132	R:R:I136	2.94	No	No	0	7	4
243	R:R:I190	R:R:I194	2.94	No	No	0	4	5
244	R:R:I194	R:R:I198	2.94	No	No	0	5	7
245	R:R:I248	R:R:L244	2.85	No	No	0	4	5
246	R:R:G144	R:R:W141	2.81	No	Yes	0	8	9
247	R:R:L122	R:R:L97	2.77	No	No	0	8	7
248	R:R:A115	R:R:F100	2.77	No	Yes	0	7	6
249	R:R:L306	R:R:L325	2.77	No	No	0	4	5
250	R:R:A355	R:R:Y345	2.67	No	Yes	0	7	7
251	R:R:H137	R:R:I136	2.65	No	No	0	4	4
252	R:R:D62	R:R:Q319	2.61	No	No	0	7	4
253	R:R:F342	R:R:T291	2.59	No	No	0	6	5
254	R:R:F300	R:R:L166	2.44	Yes	No	0	9	8
255	R:R:F256	R:R:L257	2.44	No	No	0	3	7
256	R:R:F312	R:R:L313	2.44	No	Yes	0	3	1
257	R:R:D62	R:R:F64	2.39	No	No	0	7	2
258	R:R:L203	R:R:Y210	2.34	No	No	0	3	5
259	R:R:N179	R:R:W175	2.26	No	No	0	6	5
260	R:R:A108	R:R:P109	1.87	No	No	0	7	7
261	R:R:A329	R:R:P302	1.87	No	No	0	7	9
262	R:R:G138	R:R:T75	1.82	No	No	0	4	5
263	R:R:A174	R:R:A261	1.79	No	No	0	8	7
264	R:R:G193	R:R:I192	1.76	No	No	0	2	3
265	R:R:G318	R:R:I314	1.76	No	Yes	0	1	2
266	R:R:G182	R:R:M181	1.75	No	No	0	4	5
267	R:R:P302	R:R:T301	1.75	No	No	0	9	5
268	R:R:A220	R:R:S60	1.71	No	No	0	1	7
269	R:R:G193	R:R:L196	1.71	No	No	0	2	5
270	R:R:A324	R:R:V68	1.7	No	No	0	1	4
271	R:R:A110	R:R:V347	1.7	No	No	0	8	7
272	R:R:A261	R:R:V171	1.7	No	No	0	7	6
273	R:R:N179	R:R:P180	1.63	No	No	0	6	8
274	R:R:S67	R:R:V68	1.62	No	No	0	4	4
275	R:R:A188	R:R:I112	1.62	No	No	0	3	6
276	R:R:A157	R:R:I202	1.62	No	No	0	5	8
277	R:R:A268	R:R:I177	1.62	No	No	0	5	8
278	R:R:A289	R:R:I266	1.62	No	No	0	8	5
279	R:R:A285	R:R:M265	1.61	No	No	0	7	8
280	R:R:V211	R:R:V212	1.6	No	No	0	3	4
281	R:R:T83	R:R:V87	1.59	No	No	0	5	5
282	R:R:G182	R:R:H183	1.59	No	No	0	4	6
283	R:R:C299	R:R:L335	1.59	No	No	0	9	5
284	R:R:I80	R:R:V76	1.54	No	No	0	5	4
285	R:R:I84	R:R:V88	1.54	No	No	0	5	6
286	R:R:I286	R:R:V290	1.54	No	No	0	6	5
287	R:R:N158	R:R:S124	1.49	Yes	No	0	8	7
288	R:R:L264	R:R:V178	1.49	No	No	0	4	7
289	R:R:L235	R:R:V212	1.49	No	No	0	4	4
290	R:R:L305	R:R:V309	1.49	No	No	0	6	4
291	R:R:L221	R:R:T70	1.47	Yes	No	0	3	7
292	R:R:K283	R:R:K287	1.44	No	No	0	5	5
293	R:R:I126	R:R:L90	1.43	No	Yes	0	5	6
294	R:R:Q233	R:R:V236	1.43	No	No	0	1	3
295	R:R:I298	R:R:L297	1.43	No	No	0	6	5
296	R:R:K280	R:R:N277	1.4	No	No	0	4	4
297	R:R:D238	R:R:L235	1.36	No	No	0	2	4
298	R:R:A133	R:R:Y143	1.33	No	Yes	0	4	7
299	R:R:D353	R:R:H354	1.26	No	Yes	0	4	5
300	R:R:M181	R:R:W175	1.16	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y82	7.96167	6	1	7
2	R:R:L90	3.5125	4	5	6
3	R:R:N93	7.365	4	2	9
4	R:R:F100	5.538	5	2	6
5	R:R:Y113	6.715	4	0	7
6	R:R:M114	6.95	4	2	8
7	R:R:D121	7.768	5	2	9
8	R:R:W127	5.6325	4	0	7
9	R:R:F128	7.0325	4	1	8
10	R:R:Y134	7.492	5	1	5
11	R:R:H135	7.042	5	1	5
12	R:R:N139	7.325	4	1	5
13	R:R:W141	6.98667	6	1	9
14	R:R:Y143	6.5625	4	0	7
15	R:R:Y156	8.8	4	0	5
16	R:R:N158	5.104	5	2	8
17	R:R:Y160	7.4725	4	0	7
18	R:R:F165	8.094	5	3	7
19	R:R:Q172	8.19	4	6	8
20	R:R:W199	5.48	4	3	9
21	R:R:L221	4.7225	4	0	3
22	R:R:F240	5.6575	4	0	3
23	R:R:Y242	9.2275	4	0	5
24	R:R:F243	11.695	4	0	6
25	R:R:P254	4.0625	4	0	9
26	R:R:Y262	7.182	5	0	9
27	R:R:M295	5.12	4	0	6
28	R:R:F300	9.48	4	0	9
29	R:R:H310	11.586	5	8	4
30	R:R:L313	3.45	4	0	1
31	R:R:I314	5.84	4	8	2
32	R:R:Y323	6.464	5	0	4
33	R:R:Y326	11.4325	4	0	4
34	R:R:D340	7.05	5	2	9
35	R:R:Y344	6.79875	8	2	9
36	R:R:Y345	6.065	4	0	7
37	R:R:F346	5.55	4	0	7
38	R:R:H354	6.9275	4	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S65	R:R:V61	20.3612	3.23	No	No	0	5	6
2	R:R:V229	R:R:V61	18.9708	3.21	No	No	0	4	6
3	R:R:T225	R:R:V229	17.5705	9.52	No	No	0	4	4
4	R:R:I218	R:R:T225	16.1603	4.56	No	No	0	4	4
5	R:R:S65	R:R:Y323	25.6606	6.36	No	Yes	0	5	4
6	R:R:L69	R:R:Y323	28.8323	3.52	No	Yes	0	4	4
7	R:R:L69	R:R:N139	28.2039	6.87	No	Yes	0	4	5
8	R:R:I327	R:R:Y323	22.9837	7.25	No	Yes	0	4	4
9	R:R:I327	R:R:L78	22.2712	4.28	No	No	0	4	5
10	R:R:L78	R:R:Y82	14.1267	4.69	No	Yes	1	5	7
11	R:R:H135	R:R:P79	17.7783	4.58	Yes	No	0	5	5
12	R:R:I136	R:R:P79	14.8392	5.08	No	No	0	4	5
13	R:R:H310	R:R:Y323	66.5364	7.62	Yes	Yes	0	4	4
14	R:R:H310	R:R:Y311	70.6927	6.53	Yes	No	0	4	5
15	R:R:F243	R:R:Y311	71.1677	10.32	Yes	No	0	6	5
16	R:R:F243	R:R:Y242	76.0663	12.38	Yes	Yes	0	6	5
17	R:R:L246	R:R:Y242	83.4438	7.03	No	Yes	0	5	5
18	R:R:L246	R:R:Y160	83.5181	10.55	No	Yes	0	5	7
19	R:R:V250	R:R:Y160	83.7902	6.31	No	Yes	0	5	7
20	R:R:L164	R:R:V250	83.9238	4.47	No	No	0	6	5
21	R:R:L164	R:R:P254	100	3.28	No	Yes	0	6	9
22	R:R:I163	R:R:P254	94.6759	3.39	No	Yes	0	7	9
23	R:R:F300	R:R:I163	94.1613	11.3	Yes	No	0	9	7
24	R:R:F300	R:R:M295	92.8451	8.71	Yes	Yes	0	9	6
25	R:R:D340	R:R:M295	89.2528	4.16	Yes	Yes	0	9	6
26	R:R:D121	R:R:D340	15.997	10.65	Yes	Yes	2	9	9
27	R:R:D121	R:R:S337	11.8308	5.89	Yes	No	0	9	9
28	R:R:D340	R:R:Y344	66.9223	6.9	Yes	Yes	2	9	9
29	R:R:A118	R:R:Y344	16.3731	4	No	Yes	2	8	9
30	R:R:A118	R:R:L97	15.9772	3.15	No	No	0	8	7
31	R:R:L101	R:R:L97	11.6972	5.54	No	No	0	4	7
32	R:R:F102	R:R:L101	10.2524	8.53	No	No	0	4	4
33	R:R:F100	R:R:Y344	43.6764	8.25	Yes	Yes	2	6	9
34	R:R:F100	R:R:V111	41.9891	3.93	Yes	No	0	6	7
35	R:R:M114	R:R:Y344	10.4849	7.18	Yes	Yes	2	8	9
36	R:R:T104	R:R:V111	40.856	7.93	No	No	0	6	7
37	R:R:D350	R:R:T104	39.713	7.23	No	No	0	6	6
38	R:R:D350	R:R:K106	38.5552	9.68	No	No	0	6	7
39	R:R:H349	R:R:K106	37.3676	5.24	No	No	0	5	7
40	R:R:I198	R:R:L164	48.5849	4.28	No	No	0	7	6
41	R:R:I194	R:R:I198	30.6136	2.94	No	No	0	5	7
42	R:R:I194	R:R:Y113	28.1989	6.04	No	Yes	0	5	7
43	R:R:Q172	R:R:Y113	18.3078	3.38	Yes	Yes	0	8	7
44	R:R:K187	R:R:Q172	13.147	8.14	No	Yes	6	6	8
45	R:R:F165	R:R:I198	31.5141	11.3	Yes	No	0	7	7
46	R:R:N139	R:R:Y134	16.2494	5.81	Yes	Yes	1	5	5
47	R:R:W141	R:R:Y134	22.3404	8.68	Yes	Yes	1	9	5
48	R:R:L151	R:R:W141	24.2652	4.56	No	Yes	0	5	9
49	R:R:L151	R:R:W127	24.4631	7.97	No	Yes	0	5	7
50	R:R:F154	R:R:W127	24.7353	5.01	No	Yes	0	5	7
51	R:R:F154	R:R:L123	25.0272	6.09	No	No	0	5	7
52	R:R:L119	R:R:L123	25.3538	6.92	No	No	0	6	7
53	R:R:L119	R:R:W199	25.7793	3.42	No	Yes	0	6	9
54	R:R:C148	R:R:T215	12.2266	3.38	No	No	1	9	4
55	R:R:L209	R:R:Y156	11.2172	5.86	No	Yes	0	4	5
56	R:R:L209	R:R:T206	10.1682	2.95	No	No	0	4	7
57	R:R:L209	R:R:Y242	12.2563	10.55	No	Yes	0	4	5
58	R:R:N304	R:R:Y160	10.1435	4.65	No	Yes	0	8	7
59	R:R:H349	R:R:R352	36.1999	7.9	No	No	0	5	8
60	R:R:R352	R:R:Y345	31.5438	7.2	No	Yes	0	8	7
61	R:R:F346	R:R:Y345	27.808	7.22	Yes	Yes	0	7	7
62	R:R:F346	R:R:L288	16.3978	3.65	Yes	No	0	7	8
63	R:R:L288	R:R:Y262	13.8743	9.38	No	Yes	0	8	9
64	R:R:K187	R:R:M181	12.0683	4.32	No	No	0	6	5
65	R:R:P208	R:R:Y242	11.2815	6.95	No	Yes	0	7	5
66	R:R:I207	R:R:P208	10.0148	3.39	No	No	0	4	7
67	R:R:H310	R:R:S320	26.3187	8.37	Yes	No	8	4	2
68	R:R:L313	R:R:S320	25.3785	4.5	Yes	No	0	1	2
69	R:R:F312	R:R:L313	13.0876	2.44	No	Yes	0	3	1
70	R:R:F240	R:R:F312	11.6724	6.43	Yes	No	0	3	3
71	R:R:F165	R:R:W199	24.29	5.01	Yes	Yes	3	7	9
72	R:R:H135	R:R:Y134	10.8016	10.89	Yes	Yes	1	5	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 5NJ6

PDB Summary
PDB	5NJ6
Class	A
SubFamily	Peptide
Type	Proteinase Activated
SubType	PAR2
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	4
Date	2017-05-03
D.O.I.	10.1038/nature22309

Net Summary
I_min	3.28
Number of Linked Nodes	273
Number of Links	300
Number of Hubs	38
Number of Links mediated by Hubs	144
Number of Communities	8
Number of Nodes involved in Communities	46
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	42875
Length Of Smallest Path	3
Average Path Length	15.8953
Length of Longest Path	39
Minimum Path Strength	1.425
Average Path Strength	6.45138
Maximum Path Strength	17.755
Minimum Path Correlation	0.7
Average Path Correlation	0.927527
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	46.9027
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.7858
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • protein binding • G-protein alpha-subunit binding • molecular transducer activity • signaling receptor activity • signaling receptor binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • enzyme binding • protease binding • peptide receptor activity • thrombin-activated receptor activity • proteinase-activated receptor activity • G protein-coupled peptide receptor activity • G-protein beta-subunit binding • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • multicellular organismal process • regulation of body fluid levels • wound healing • response to stimulus • hemostasis • biological regulation • blood coagulation • response to stress • coagulation • regulation of biological quality
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • multicellular organismal process • regulation of body fluid levels • wound healing • response to stimulus • hemostasis • biological regulation • blood coagulation • response to stress • coagulation • regulation of biological quality • response to wounding • developmental process • myeloid leukocyte differentiation • cellular developmental process • hemopoiesis • cell development • mononuclear cell differentiation • myeloid cell differentiation • cell differentiation • anatomical structure development • dendritic cell differentiation • mature conventional dendritic cell differentiation • leukocyte differentiation • regulation of biological process • regulation of cellular process • reactive oxygen species metabolic process • positive regulation of biological process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • positive regulation of cellular process • cellular response to stimulus • regulation of signaling • signaling • regulation of JNK cascade • regulation of signal transduction • regulation of MAPK cascade • intracellular signal transduction • cell communication • regulation of intracellular signal transduction • regulation of response to stimulus • JNK cascade • intracellular signaling cassette • MAPK cascade • regulation of cell communication • signal transduction • regulation of cellular component organization • positive regulation of cellular component organization • cell projection organization • plasma membrane bounded cell projection assembly • cellular component biogenesis • cellular component organization • pseudopodium assembly • cellular component assembly • positive regulation of cell projection organization • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • positive regulation of cellular component biogenesis • regulation of cell projection organization • regulation of cell projection assembly • regulation of cellular component biogenesis • regulation of plasma membrane bounded cell projection assembly • positive regulation of pseudopodium assembly • regulation of pseudopodium assembly • cell projection assembly • regulation of plasma membrane bounded cell projection organization • positive regulation of plasma membrane bounded cell projection assembly • pseudopodium organization • chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • response to external stimulus • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • taxis • response to chemical • regulation of locomotion • locomotion • biological process involved in interspecies interaction between organisms • immune response • response to other organism • defense response • defense response to symbiont • response to biotic stimulus • immune system process • defense response to other organism • innate immune response • response to external biotic stimulus • positive regulation of cell communication • positive regulation of response to biotic stimulus • positive regulation of signal transduction • pattern recognition receptor signaling pathway • immune response-activating signaling pathway • positive regulation of toll-like receptor 3 signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • innate immune response-activating signaling pathway • positive regulation of pattern recognition receptor signaling pathway • regulation of innate immune response • positive regulation of intracellular signal transduction • regulation of pattern recognition receptor signaling pathway • positive regulation of defense response • regulation of immune response • activation of innate immune response • activation of immune response • regulation of defense response • cytoplasmic pattern recognition receptor signaling pathway • regulation of response to biotic stimulus • intracellular receptor signaling pathway • regulation of cytoplasmic pattern recognition receptor signaling pathway • endolysosomal toll-like receptor signaling pathway • immune response-regulating signaling pathway • regulation of response to stress • regulation of toll-like receptor 3 signaling pathway • positive regulation of innate immune response • toll-like receptor 3 signaling pathway • positive regulation of signaling • regulation of biosynthetic process • chemokine (C-X-C motif) ligand 2 production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of chemokine production • regulation of gene expression • regulation of chemokine (C-X-C motif) ligand 2 production • biosynthetic process • regulation of cytokine production • cytokine production • chemokine production • regulation of macromolecule biosynthetic process • regulation of multicellular organismal process • macromolecule metabolic process • negative regulation of biological process • negative regulation of chemokine production • negative regulation of cellular process • negative regulation of macromolecule metabolic process • negative regulation of metabolic process • negative regulation of cytokine production • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of multicellular organismal process • interleukin-1 production • regulation of interleukin-1 beta production • positive regulation of macromolecule biosynthetic process • positive regulation of interleukin-1 beta production • positive regulation of biosynthetic process • positive regulation of interleukin-1 production • positive regulation of macromolecule metabolic process • regulation of interleukin-1 production • interleukin-1 beta production • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of cytokine production • positive regulation of interleukin-8 production • interleukin-8 production • regulation of interleukin-8 production • positive regulation of JNK cascade • positive regulation of MAPK cascade • positive regulation of chemokine production • system process • renal system process • regulation of renal system process • regulation of blood pressure • regulation of system process • regulation of glomerular filtration • positive regulation of glomerular filtration • regulation of systemic arterial blood pressure • circulatory system process • renal system process involved in regulation of blood volume • renal system process involved in regulation of systemic arterial blood pressure • glomerular filtration • blood circulation • renal filtration • negative regulation of signaling • negative regulation of cytoplasmic pattern recognition receptor signaling pathway • negative regulation of intracellular signal transduction • negative regulation of cell communication • negative regulation of toll-like receptor 3 signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of immune system process • interleukin-10 production • regulation of interleukin-10 production • positive regulation of interleukin-10 production • protein localization • regulation of systemic arterial blood pressure by renin-angiotensin • regulation of localization • regulation of systemic arterial blood pressure by hormone • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure • cellular macromolecule localization • establishment of protein localization to extracellular region • regulation of systemic arterial blood pressure by circulatory renin-angiotensin • protein secretion • establishment of localization • positive regulation of renin secretion into blood stream • regulation of protein secretion • regulation of secretion • positive regulation of protein localization • regulation of endocrine process • renin secretion into blood stream • cellular localization • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of protein localization • transport • positive regulation of secretion by cell • protein localization to extracellular region • positive regulation of protein transport • regulation of secretion by cell • secretion by cell • regulation of renin secretion into blood stream • positive regulation of secretion • signal release • regulation of transport • secretion • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • endocrine process • positive regulation of transport • protein transport • regulation of cellular localization • macromolecule localization • cell activation • lymphocyte activation • cell activation involved in immune response • leukocyte activation • immune effector process • T cell activation involved in immune response • T cell activation • leukocyte activation involved in immune response • lymphocyte activation involved in immune response • regulation of immune effector process • regulation of myeloid leukocyte mediated immunity • regulated exocytosis • positive regulation of leukocyte mediated immunity • leukocyte degranulation • myeloid leukocyte mediated immunity • vesicle-mediated transport • myeloid leukocyte activation • positive regulation of leukocyte degranulation • positive regulation of regulated secretory pathway • establishment of localization in cell • leukocyte mediated immunity • regulation of leukocyte mediated immunity • exocytosis • positive regulation of myeloid leukocyte mediated immunity • eosinophil mediated immunity • eosinophil activation • positive regulation of exocytosis • regulation of regulated secretory pathway • regulation of eosinophil degranulation • positive regulation of eosinophil degranulation • eosinophil degranulation • positive regulation of immune effector process • eosinophil activation involved in immune response • regulation of leukocyte degranulation • regulation of vesicle-mediated transport • myeloid cell activation involved in immune response • regulation of exocytosis • granulocyte activation • defense response to virus • response to virus • positive regulation of DNA-templated transcription • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • primary metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • regulation of cell motility • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • cell chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • positive regulation of leukocyte migration • leukocyte migration • cellular response to chemical stimulus • leukocyte chemotaxis • cell population proliferation • leukocyte proliferation • positive regulation of cytosolic calcium ion concentration • positive regulation of canonical NF-kappaB signal transduction • canonical NF-kappaB signal transduction • regulation of canonical NF-kappaB signal transduction • immune response-regulating cell surface receptor signaling pathway • cell surface toll-like receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • regulation of toll-like receptor 4 signaling pathway • positive regulation of toll-like receptor 4 signaling pathway • innate immune response activating cell surface receptor signaling pathway • cell surface pattern recognition receptor signaling pathway • cell surface receptor signaling pathway • toll-like receptor 4 signaling pathway • positive regulation of ERK1 and ERK2 cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • import into cell • positive regulation of membrane invagination • positive regulation of endocytosis • regulation of phagocytosis, engulfment • membrane invagination • phagocytosis • plasma membrane invagination • regulation of endocytosis • membrane organization • regulation of phagocytosis • phagocytosis, engulfment • positive regulation of phagocytosis • positive regulation of phagocytosis, engulfment • regulation of membrane invagination • endocytosis • positive regulation of organelle organization • regulation of cytoskeleton organization • regulation of actin filament-based process • regulation of cellular component size • protein-containing complex disassembly • positive regulation of actin filament depolymerization • regulation of protein-containing complex disassembly • actin filament depolymerization • regulation of actin filament depolymerization • actin filament-based process • positive regulation of protein-containing complex disassembly • cellular component disassembly • actin polymerization or depolymerization • regulation of actin filament organization • actin cytoskeleton organization • protein-containing complex organization • regulation of protein depolymerization • positive regulation of protein depolymerization • positive regulation of cytoskeleton organization • actin filament organization • regulation of actin polymerization or depolymerization • positive regulation of supramolecular fiber organization • regulation of organelle organization • organelle organization • regulation of actin filament length • regulation of actin cytoskeleton organization • regulation of supramolecular fiber organization • supramolecular fiber organization • protein depolymerization • cytoskeleton organization • regulation of anatomical structure size • interleukin-6 production • positive regulation of interleukin-6 production • regulation of interleukin-6 production • neutrophil-mediated killing of symbiont cell • regulation of killing of cells of another organism • disruption of cell in another organism • regulation of programmed cell death • positive regulation of neutrophil mediated cytotoxicity • positive regulation of leukocyte mediated cytotoxicity • response to bacterium • positive regulation of neutrophil mediated killing of symbiont cell • regulation of neutrophil mediated killing of gram-negative bacterium • biological process involved in interaction with symbiont • killing of cells of another organism • positive regulation of programmed cell death • leukocyte mediated cytotoxicity • cell death • positive regulation of neutrophil mediated killing of bacterium • regulation of cell killing • positive regulation of cell killing • disruption of anatomical structure in another organism • positive regulation of killing of cells of another organism • positive regulation of neutrophil mediated killing of gram-negative bacterium • defense response to Gram-negative bacterium • biological process involved in symbiotic interaction • regulation of neutrophil mediated killing of bacterium • defense response to bacterium • positive regulation of defense response to bacterium • neutrophil mediated immunity • modulation of process of another organism • regulation of biological process involved in symbiotic interaction • regulation of defense response to bacterium • neutrophil-mediated killing of bacterium • neutrophil mediated cytotoxicity • regulation of neutrophil mediated cytotoxicity • regulation of leukocyte mediated cytotoxicity • regulation of neutrophil mediated killing of symbiont cell • killing by host of symbiont cells • neutrophil-mediated killing of gram-negative bacterium • programmed cell death • cell killing • positive regulation of molecular function • regulation of molecular function • positive regulation of hydrolase activity • regulation of catalytic activity • regulation of hydrolase activity • positive regulation of catalytic activity • regulation of GTPase activity • positive regulation of GTPase activity • neutrophil activation • regulation of toll-like receptor 2 signaling pathway • positive regulation of toll-like receptor 2 signaling pathway • toll-like receptor 2 signaling pathway • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • positive regulation of small GTPase mediated signal transduction • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • negative regulation of establishment of protein localization • negative regulation of protein secretion • regulation of hormone secretion • regulation of peptide secretion • hormone secretion • negative regulation of peptide secretion • peptide secretion • amide transport • negative regulation of protein localization • regulation of peptide transport • peptide transport • negative regulation of insulin secretion • regulation of insulin secretion • peptide hormone secretion • hormone transport • insulin secretion • negative regulation of JNK cascade • negative regulation of MAPK cascade • regulation of tube diameter • regulation of tube size • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • positive chemotaxis • positive regulation of positive chemotaxis • regulation of positive chemotaxis • epithelium development • endothelial cell differentiation • endothelium development • tissue development • epithelial cell differentiation • endothelial cell development • epithelial cell development • establishment of endothelial barrier • cell junction maintenance • cell junction organization • cellular component maintenance • cell-cell junction maintenance • cell-cell junction organization • inflammatory response • G protein-coupled receptor signaling pathway • regulation of blood coagulation • regulation of coagulation • regulation of response to wounding • regulation of wound healing • regulation of hemostasis • cytokine production involved in immune response • production of molecular mediator of immune response • regulation of cytokine production involved in immune response • positive regulation of cytokine production involved in immune response • positive regulation of production of molecular mediator of immune response • regulation of production of molecular mediator of immune response • response to cytokine • cytokine-mediated signaling pathway • cellular response to tumor necrosis factor • tumor necrosis factor-mediated signaling pathway • cellular response to cytokine stimulus • regulation of tumor necrosis factor-mediated signaling pathway • regulation of cytokine-mediated signaling pathway • negative regulation of tumor necrosis factor-mediated signaling pathway • response to peptide • regulation of response to cytokine stimulus • negative regulation of response to cytokine stimulus • negative regulation of cytokine-mediated signaling pathway • response to tumor necrosis factor • regulation of type II interferon production • type II interferon production • positive regulation of type II interferon production • cellular anatomical structure • periplasmic space • cell projection • pseudopodium • plasma membrane bounded cell projection • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • Golgi apparatus • organelle • cytoplasm • intracellular membrane-bounded organelle • endomembrane system • cell periphery
Gene Ontology	Cellular Component	• cellular anatomical structure • periplasmic space • cell projection • pseudopodium • plasma membrane bounded cell projection • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • Golgi apparatus • organelle • cytoplasm • intracellular membrane-bounded organelle • endomembrane system • cell periphery • plasma membrane • membrane • early endosome • endosome • intracellular vesicle • cytoplasmic vesicle • vesicle
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Cytochromes
SCOP2	Family Identifier	• G protein-coupled receptor-like • Cytochromes
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P55085
Sequence	>5NJ6_Chain_R F S V D E F S A S V L T G K L T T V F L P I V Y T I V F V V A L P S N G M A L W V F L F R T K K K A P A V I Y M A N L A L A D L L S V I W F P L K I A Y H I H G N N W I Y G E A L C N V L I G F F Y A N M Y C S I L F L T C L S V Q R A W E I V N P M G H S R K K A N I A I G I S L A I W L L I L L V T I P L Y V V K Q T I F I P A L Q I T T C H D V L P E Q L L V G D M F N Y F L S L A I G V F L F P A F L T A S A Y V L M I R A L E N S E K K R K R A I K L A V T V A A M Y L I C F T P S N L L L V V H Y F L I K S Q G Q S H V Y A L Y I V A L C L S T L N S C I D P F V Y Y F V S H D F R D H A K N A L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5NJ6	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-	-	4	2017-05-03	10.1038/nature22309
	5NDZ	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	AZ3451; Na	-	3.6	2017-05-03	10.1038/nature22309
	5NDD	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	AZ8838; Na	-	2.8	2017-05-03	10.1038/nature22309

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