psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H227	R:R:S37	6.97	No	No	0	5	8
2	R:R:L230	R:R:S37	9.01	No	No	2	5	8
3	R:R:L235	R:R:S37	6.01	No	No	2	4	8
4	R:R:L38	R:R:Y323	5.86	No	Yes	0	8	4
5	R:R:I39	R:R:S320	9.29	No	Yes	0	7	2
6	R:R:D62	R:R:S65	8.83	No	No	0	7	5
7	R:R:E63	R:R:F64	3.5	No	No	0	5	2
8	R:R:F64	R:R:H321	4.53	No	No	0	2	4
9	R:R:H321	R:R:S65	5.58	No	No	0	4	5
10	R:R:L69	R:R:N139	12.36	No	Yes	0	4	5
11	R:R:H135	R:R:T74	8.21	No	Yes	0	5	4
12	R:R:N139	R:R:T74	7.31	Yes	Yes	0	5	4
13	R:R:F77	R:R:L78	3.65	No	No	0	4	5
14	R:R:F77	R:R:V328	3.93	No	No	0	4	6
15	R:R:I327	R:R:L78	4.28	No	No	0	4	5
16	R:R:H135	R:R:P79	6.1	No	No	0	5	5
17	R:R:C331	R:R:V81	6.83	No	No	0	6	6
18	R:R:F128	R:R:Y82	13.41	Yes	Yes	2	8	7
19	R:R:K131	R:R:Y82	8.36	No	Yes	0	7	7
20	R:R:F155	R:R:Y82	9.28	Yes	Yes	2	6	7
21	R:R:T334	R:R:Y82	11.24	Yes	Yes	2	7	7
22	R:R:I132	R:R:T83	4.56	No	No	0	7	5
23	R:R:T334	R:R:V85	4.76	Yes	No	0	7	8
24	R:R:F86	R:R:L90	3.65	No	No	0	6	6
25	R:R:F128	R:R:F86	6.43	Yes	No	0	8	6
26	R:R:F86	R:R:P129	7.22	No	No	0	6	8
27	R:R:C338	R:R:V88	3.42	No	No	0	7	6
28	R:R:G89	R:R:S92	3.71	No	Yes	0	8	7
29	R:R:N93	R:R:S92	5.96	No	Yes	1	9	7
30	R:R:P341	R:R:S92	8.91	No	Yes	1	9	7
31	R:R:D121	R:R:N93	13.46	Yes	No	1	9	9
32	R:R:N93	R:R:P341	13.03	No	No	1	9	9
33	R:R:G94	R:R:L122	5.13	No	No	0	4	8
34	R:R:F346	R:R:M95	4.98	No	No	0	7	6
35	R:R:A118	R:R:L97	4.73	No	No	0	8	7
36	R:R:F102	R:R:W98	21.05	No	No	0	4	3
37	R:R:F351	R:R:V99	3.93	Yes	No	0	8	8
38	R:R:F100	R:R:V111	3.93	Yes	No	0	6	7
39	R:R:F100	R:R:M114	6.22	Yes	No	1	6	8
40	R:R:A115	R:R:F100	4.16	No	Yes	0	7	6
41	R:R:F100	R:R:Y345	12.38	Yes	Yes	1	6	7
42	R:R:F100	R:R:F351	9.65	Yes	Yes	1	6	8
43	R:R:F102	R:R:R103	9.62	No	No	0	4	5
44	R:R:A358	R:R:R103	5.53	No	No	0	5	5
45	R:R:H108	R:R:P109	9.15	No	No	6	7	7
46	R:R:H108	R:R:S184	6.97	No	No	6	7	4
47	R:R:P109	R:R:S184	3.56	No	No	6	7	4
48	R:R:A191	R:R:I112	6.5	No	No	0	8	6
49	R:R:I112	R:R:I192	4.42	No	No	0	6	3
50	R:R:C168	R:R:Y113	8.06	No	Yes	0	7	7
51	R:R:L169	R:R:Y113	4.69	No	Yes	0	8	7
52	R:R:Q172	R:R:Y113	12.4	No	Yes	0	8	7
53	R:R:A191	R:R:Y113	4	No	Yes	0	8	7
54	R:R:I194	R:R:Y113	3.63	No	Yes	0	5	7
55	R:R:M114	R:R:Y345	8.38	No	Yes	1	8	7
56	R:R:F165	R:R:N116	14.5	Yes	No	4	7	9
57	R:R:N116	R:R:S195	8.94	No	No	4	9	7
58	R:R:D121	R:R:L117	4.07	Yes	Yes	1	9	9
59	R:R:L117	R:R:S162	4.5	Yes	No	1	9	9
60	R:R:L117	R:R:M166	4.24	Yes	Yes	1	9	8
61	R:R:D340	R:R:L117	4.07	Yes	Yes	1	9	9
62	R:R:L117	R:R:Y345	4.69	Yes	Yes	1	9	7
63	R:R:L119	R:R:L123	5.54	No	No	0	6	7
64	R:R:L119	R:R:W199	6.83	No	No	0	6	9
65	R:R:D121	R:R:S162	4.42	Yes	No	1	9	9
66	R:R:D121	R:R:S337	4.42	Yes	No	0	9	9
67	R:R:D121	R:R:D340	6.65	Yes	Yes	1	9	9
68	R:R:L123	R:R:N158	13.73	No	No	0	7	8
69	R:R:N158	R:R:S124	4.47	No	No	0	8	7
70	R:R:F128	R:R:V125	9.18	Yes	No	0	8	6
71	R:R:I126	R:R:W127	7.05	No	Yes	0	5	7
72	R:R:V150	R:R:W127	8.58	No	Yes	0	5	7
73	R:R:L151	R:R:W127	4.56	No	Yes	0	5	7
74	R:R:F154	R:R:W127	15.03	No	Yes	0	5	7
75	R:R:F128	R:R:F155	8.57	Yes	Yes	2	8	6
76	R:R:F128	R:R:T334	5.19	Yes	Yes	2	8	7
77	R:R:L130	R:R:Y143	8.21	No	No	3	7	7
78	R:R:L130	R:R:L147	4.15	No	No	3	7	6
79	R:R:H135	R:R:K131	6.55	No	No	0	5	7
80	R:R:K131	R:R:L151	9.87	No	No	0	7	5
81	R:R:N139	R:R:Y134	3.49	Yes	Yes	3	5	5
82	R:R:W141	R:R:Y134	9.65	Yes	Yes	3	9	5
83	R:R:T225	R:R:Y134	7.49	Yes	Yes	3	4	5
84	R:R:D228	R:R:Y134	10.34	Yes	Yes	3	4	5
85	R:R:N139	R:R:T225	5.85	Yes	Yes	3	5	4
86	R:R:D228	R:R:N139	5.39	Yes	Yes	3	4	5
87	R:R:I223	R:R:N140	8.5	No	No	0	3	4
88	R:R:L147	R:R:W141	4.56	No	Yes	3	6	9
89	R:R:C148	R:R:W141	7.84	No	Yes	3	9	9
90	R:R:L151	R:R:W141	3.42	No	Yes	0	5	9
91	R:R:C226	R:R:W141	7.84	No	Yes	3	9	9
92	R:R:I142	R:R:Y143	9.67	No	No	0	1	7
93	R:R:L147	R:R:Y143	5.86	No	No	3	6	7
94	R:R:E145	R:R:T215	4.23	No	No	0	3	4
95	R:R:C148	R:R:C226	7.28	No	No	3	9	9
96	R:R:N149	R:R:Q214	14.52	No	No	0	6	4
97	R:R:H227	R:R:I152	9.28	No	No	0	5	5
98	R:R:G153	R:R:L209	3.42	No	No	0	6	4
99	R:R:G153	R:R:Y210	4.35	No	No	0	6	5
100	R:R:F154	R:R:N158	6.04	No	No	0	5	8
101	R:R:F154	R:R:Y210	4.13	No	No	0	5	5
102	R:R:F155	R:R:Y156	6.19	Yes	Yes	2	6	5
103	R:R:F155	R:R:L330	4.87	Yes	No	2	6	5
104	R:R:F155	R:R:T334	7.78	Yes	Yes	2	6	7
105	R:R:F243	R:R:Y156	5.16	Yes	Yes	2	6	5
106	R:R:Y156	R:R:Y326	4.96	Yes	No	0	5	4
107	R:R:L330	R:R:Y156	3.52	No	Yes	2	5	5
108	R:R:M159	R:R:Y160	3.59	No	Yes	0	7	7
109	R:R:L246	R:R:Y160	18.76	No	Yes	0	5	7
110	R:R:V250	R:R:Y160	6.31	No	Yes	0	5	7
111	R:R:N304	R:R:Y160	8.14	No	Yes	0	8	7
112	R:R:C161	R:R:F165	4.19	Yes	Yes	4	7	7
113	R:R:C161	R:R:W199	9.14	Yes	No	4	7	9
114	R:R:C161	R:R:I202	8.18	Yes	No	0	7	8
115	R:R:F251	R:R:I163	5.02	Yes	No	1	8	7
116	R:R:F300	R:R:I163	16.33	Yes	No	1	9	7
117	R:R:I198	R:R:L164	4.28	No	No	0	7	6
118	R:R:L164	R:R:V250	4.47	No	No	0	6	5
119	R:R:F165	R:R:S195	3.96	Yes	No	4	7	7
120	R:R:F165	R:R:W199	13.03	Yes	No	4	7	9
121	R:R:M166	R:R:Y296	4.79	Yes	Yes	0	8	9
122	R:R:F300	R:R:M166	3.73	Yes	Yes	1	9	8
123	R:R:D340	R:R:M166	4.16	Yes	Yes	1	9	8
124	R:R:M166	R:R:Y344	7.18	Yes	Yes	1	8	9
125	R:R:P254	R:R:T167	6.99	No	No	0	9	7
126	R:R:T167	R:R:Y296	3.75	No	Yes	0	7	9
127	R:R:S170	R:R:T258	6.4	Yes	No	0	9	8
128	R:R:A261	R:R:S170	3.42	No	Yes	0	7	9
129	R:R:S170	R:R:Y262	6.36	Yes	Yes	0	9	9
130	R:R:R173	R:R:Y262	7.2	No	Yes	1	9	9
131	R:R:M265	R:R:R173	3.72	No	No	1	8	9
132	R:R:R173	R:R:Y344	6.17	No	Yes	1	9	9
133	R:R:V178	R:R:Y174	13.88	No	No	0	7	8
134	R:R:L264	R:R:Y174	9.38	No	No	0	4	8
135	R:R:H183	R:R:V176	5.54	Yes	No	0	6	8
136	R:R:N179	R:R:V178	4.43	No	No	0	6	7
137	R:R:M268	R:R:V178	6.09	No	No	0	5	7
138	R:R:H183	R:R:M181	3.94	Yes	No	0	6	5
139	R:R:H183	R:R:K187	28.82	Yes	No	0	6	6
140	R:R:I190	R:R:K187	7.27	No	No	0	4	6
141	R:R:L203	R:R:L204	4.15	No	No	0	3	4
142	R:R:L209	R:R:T206	4.42	No	No	0	4	7
143	R:R:I207	R:R:P208	5.08	No	No	0	4	7
144	R:R:L209	R:R:Y242	15.24	No	No	0	4	5
145	R:R:D238	R:R:V212	7.3	No	No	0	2	4
146	R:R:M239	R:R:V212	6.09	No	No	0	4	4
147	R:R:I216	R:R:P231	6.77	No	No	0	1	4
148	R:R:F217	R:R:N222	7.25	No	No	0	1	5
149	R:R:F217	R:R:T224	6.49	No	No	0	1	5
150	R:R:I218	R:R:V229	6.14	No	No	0	4	4
151	R:R:I223	R:R:L221	5.71	No	No	0	3	3
152	R:R:D228	R:R:T225	7.23	Yes	Yes	3	4	4
153	R:R:D228	R:R:Y323	4.6	Yes	Yes	0	4	4
154	R:R:L230	R:R:P231	4.93	No	No	0	5	4
155	R:R:L230	R:R:L235	8.3	No	No	2	5	4
156	R:R:L234	R:R:P231	8.21	No	No	0	5	4
157	R:R:L235	R:R:Y311	3.52	No	Yes	2	4	5
158	R:R:F243	R:R:M239	7.46	Yes	No	0	6	4
159	R:R:F240	R:R:N241	3.62	Yes	No	0	3	3
160	R:R:F240	R:R:L244	3.65	Yes	No	0	3	5
161	R:R:F240	R:R:K315	14.89	Yes	No	0	3	2
162	R:R:F243	R:R:Y242	9.28	Yes	No	0	6	5
163	R:R:L246	R:R:Y242	8.21	No	No	0	5	5
164	R:R:F243	R:R:L307	7.31	Yes	Yes	2	6	5
165	R:R:F243	R:R:Y311	15.47	Yes	Yes	2	6	5
166	R:R:G249	R:R:I248	3.53	No	No	0	5	4
167	R:R:I248	R:R:L252	4.28	No	No	0	4	4
168	R:R:F251	R:R:L252	3.65	Yes	No	0	8	4
169	R:R:F251	R:R:F300	4.29	Yes	Yes	1	8	9
170	R:R:F251	R:R:T301	6.49	Yes	No	0	8	5
171	R:R:F251	R:R:N304	19.33	Yes	No	0	8	8
172	R:R:F256	R:R:L252	6.09	No	No	0	3	4
173	R:R:A255	R:R:Y296	4	No	Yes	0	7	9
174	R:R:T258	R:R:Y296	9.99	No	Yes	0	8	9
175	R:R:M265	R:R:Y262	5.99	No	Yes	1	8	9
176	R:R:I289	R:R:Y262	7.25	No	Yes	0	8	9
177	R:R:V292	R:R:Y262	5.05	No	Yes	0	8	9
178	R:R:L293	R:R:Y262	4.69	Yes	Yes	0	8	9
179	R:R:I266	R:R:I286	8.83	No	Yes	0	5	6
180	R:R:I266	R:R:I289	7.36	No	No	0	5	8
181	R:R:I286	R:R:L269	4.28	Yes	No	0	6	8
182	R:R:I286	R:R:R270	3.76	Yes	No	0	6	4
183	R:R:M274	R:R:R282	13.65	No	No	0	4	6
184	R:R:R282	R:R:S278	15.81	No	No	0	6	4
185	R:R:K280	R:R:K281	5.75	No	No	0	4	5
186	R:R:L288	R:R:R284	3.64	No	No	7	8	7
187	R:R:R284	R:R:V347	3.92	No	No	7	7	7
188	R:R:L288	R:R:V347	7.45	No	No	7	8	7
189	R:R:V292	R:R:Y344	10.09	No	Yes	0	8	9
190	R:R:L293	R:R:L297	8.3	Yes	No	0	8	5
191	R:R:I339	R:R:M295	5.83	No	No	0	6	6
192	R:R:L297	R:R:Y296	3.52	No	Yes	0	5	9
193	R:R:C299	R:R:N336	9.45	No	No	0	9	9
194	R:R:F300	R:R:S333	6.61	Yes	No	0	9	8
195	R:R:F300	R:R:N336	10.87	Yes	No	0	9	9
196	R:R:P302	R:R:T301	5.25	No	No	0	9	5
197	R:R:N304	R:R:S303	4.47	No	No	0	8	7
198	R:R:S303	R:R:S333	6.52	No	No	0	7	8
199	R:R:L306	R:R:L325	4.15	No	No	0	4	5
200	R:R:L307	R:R:Y311	4.69	Yes	Yes	2	5	5
201	R:R:L307	R:R:Y326	14.07	Yes	No	0	5	4
202	R:R:V309	R:R:V322	6.41	No	No	0	4	4
203	R:R:H310	R:R:I314	9.28	Yes	No	5	4	2
204	R:R:H310	R:R:S320	5.58	Yes	Yes	5	4	2
205	R:R:H310	R:R:V322	5.54	Yes	No	0	4	4
206	R:R:H310	R:R:Y323	7.62	Yes	Yes	0	4	4
207	R:R:L313	R:R:Q317	3.99	No	No	0	1	1
208	R:R:I314	R:R:S320	7.74	No	Yes	5	2	2
209	R:R:Q317	R:R:Q319	7.68	No	No	0	1	4
210	R:R:I327	R:R:Y323	3.63	No	Yes	0	4	4
211	R:R:D340	R:R:N336	10.77	Yes	No	0	9	9
212	R:R:D340	R:R:Y344	3.45	Yes	Yes	1	9	9
213	R:R:V343	R:R:Y344	5.05	No	Yes	0	8	9
214	R:R:Y344	R:R:Y345	3.97	Yes	Yes	1	9	7
215	R:R:F351	R:R:Y345	7.22	Yes	Yes	1	8	7
216	R:R:F346	R:R:F351	10.72	No	Yes	0	7	8
217	R:R:D350	R:R:S348	4.42	No	No	0	6	8
218	R:R:D350	R:R:H354	3.78	No	No	0	6	5
219	R:R:D353	R:R:N357	4.04	No	No	0	4	4
220	R:R:I136	R:R:P79	3.39	No	No	0	4	5
221	R:R:G138	R:R:N139	3.39	No	Yes	0	4	5
222	R:R:I218	R:R:P219	3.39	No	No	0	4	1
223	R:R:L90	R:R:P91	3.28	No	No	0	6	5
224	R:R:S170	R:R:V171	3.23	Yes	No	0	9	6
225	R:R:V87	R:R:V88	3.21	No	No	0	5	6
226	R:R:V211	R:R:V212	3.21	No	No	0	3	4
227	R:R:V343	R:R:V347	3.21	No	No	0	8	7
228	R:R:T225	R:R:V229	3.17	Yes	No	0	4	4
229	R:R:T291	R:R:V343	3.17	No	No	0	5	8
230	R:R:T215	R:R:T224	3.14	No	No	0	4	5
231	R:R:F240	R:R:Y311	3.09	Yes	Yes	0	3	5
232	R:R:K283	R:R:S278	3.06	No	No	0	5	4
233	R:R:C148	R:R:Q214	3.05	No	No	0	9	4
234	R:R:A110	R:R:Q172	3.03	No	No	0	8	8
235	R:R:L38	R:R:S65	3	No	No	0	8	5
236	R:R:L196	R:R:S195	3	No	No	0	5	7
237	R:R:L38	R:R:V68	2.98	No	No	0	8	4
238	R:R:L335	R:R:V85	2.98	No	No	0	5	8
239	R:R:L201	R:R:V205	2.98	No	No	0	5	5
240	R:R:L313	R:R:V322	2.98	No	No	0	1	4
241	R:R:L257	R:R:T167	2.95	No	No	0	7	7
242	R:R:A110	R:R:H108	2.93	No	No	0	8	7
243	R:R:I177	R:R:M268	2.92	No	No	0	8	5
244	R:R:L169	R:R:M114	2.83	No	No	0	8	8
245	R:R:G144	R:R:W141	2.81	No	Yes	0	8	9
246	R:R:L122	R:R:L90	2.77	No	No	0	8	6
247	R:R:A96	R:R:F100	2.77	No	Yes	0	9	6
248	R:R:L101	R:R:L97	2.77	No	No	0	4	7
249	R:R:L122	R:R:L97	2.77	No	No	0	8	7
250	R:R:H137	R:R:I142	2.65	No	No	0	4	1
251	R:R:F342	R:R:S92	2.64	No	Yes	0	6	7
252	R:R:F312	R:R:S316	2.64	No	No	0	3	1
253	R:R:F351	R:R:S348	2.64	Yes	No	0	8	8
254	R:R:F77	R:R:V81	2.62	No	No	0	4	6
255	R:R:V171	R:R:W175	2.45	No	No	0	6	5
256	R:R:L264	R:R:R267	2.43	No	No	0	4	4
257	R:R:I207	R:R:Y210	2.42	No	No	0	4	5
258	R:R:M265	R:R:Y174	2.39	No	No	0	8	8
259	R:R:L306	R:R:Y326	2.34	No	No	0	4	4
260	R:R:F253	R:R:F256	2.14	No	No	0	6	3
261	R:R:C338	R:R:G89	1.96	No	No	0	7	8
262	R:R:G318	R:R:S320	1.86	No	Yes	0	1	2
263	R:R:G71	R:R:T70	1.82	No	No	0	3	7
264	R:R:G71	R:R:T75	1.82	No	No	0	3	5
265	R:R:G157	R:R:T206	1.82	No	No	0	5	7
266	R:R:A120	R:R:C161	1.81	No	Yes	0	8	7
267	R:R:G193	R:R:I192	1.76	No	No	0	2	3
268	R:R:A324	R:R:V68	1.7	No	No	0	1	4
269	R:R:G237	R:R:N241	1.7	No	No	0	1	3
270	R:R:A247	R:R:V308	1.7	No	No	0	5	6
271	R:R:C299	R:R:I298	1.64	No	No	0	9	6
272	R:R:L332	R:R:P302	1.64	No	No	0	8	9
273	R:R:N179	R:R:P180	1.63	No	No	0	6	8
274	R:R:A188	R:R:I112	1.62	No	No	0	3	6
275	R:R:A220	R:R:I218	1.62	No	No	0	1	4
276	R:R:C299	R:R:M295	1.62	No	No	0	9	6
277	R:R:A294	R:R:M295	1.61	No	No	0	5	6
278	R:R:T83	R:R:V87	1.59	No	No	0	5	5
279	R:R:T104	R:R:V99	1.59	No	No	0	6	8
280	R:R:A247	R:R:L307	1.58	No	Yes	0	5	5
281	R:R:A259	R:R:L293	1.58	No	Yes	0	4	8
282	R:R:A285	R:R:L269	1.58	No	No	0	7	8
283	R:R:A329	R:R:L306	1.58	No	No	0	7	4
284	R:R:A358	R:R:L359	1.58	No	No	0	5	5
285	R:R:T74	R:R:T75	1.57	Yes	No	0	4	5
286	R:R:I177	R:R:V176	1.54	No	No	0	8	8
287	R:R:I314	R:R:V236	1.54	No	No	0	2	3
288	R:R:I266	R:R:V290	1.54	No	No	0	5	5
289	R:R:K315	R:R:S316	1.53	No	No	0	2	1
290	R:R:K72	R:R:V76	1.52	No	No	0	2	4
291	R:R:I223	R:R:T225	1.52	No	Yes	0	3	4
292	R:R:K106	R:R:T104	1.5	No	No	0	7	6
293	R:R:L246	R:R:V205	1.49	No	No	0	5	5
294	R:R:L293	R:R:V263	1.49	Yes	No	0	8	3
295	R:R:L73	R:R:T74	1.47	No	Yes	0	3	4
296	R:R:I286	R:R:K283	1.45	Yes	No	0	6	5
297	R:R:L359	R:R:M95	1.41	No	No	0	5	6
298	R:R:A355	R:R:F346	1.39	No	No	0	7	7
299	R:R:D353	R:R:K356	1.38	No	No	0	4	4
300	R:R:D275	R:R:N277	1.35	No	No	0	4	4
301	R:R:L234	R:R:Q233	1.33	No	No	0	5	1
302	R:R:H183	R:R:K186	1.31	Yes	No	0	6	7
303	R:R:E276	R:R:N277	1.31	No	No	0	1	4
304	R:R:T224	R:R:W141	1.21	No	Yes	0	5	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T74	4.64	4	0	4
2	R:R:Y82	10.5725	4	2	7
3	R:R:S92	5.305	4	1	7
4	R:R:F100	6.51833	6	1	6
5	R:R:Y113	6.556	5	0	7
6	R:R:L117	4.314	5	1	9
7	R:R:D121	6.604	5	1	9
8	R:R:W127	8.805	4	0	7
9	R:R:F128	8.556	5	2	8
10	R:R:Y134	7.7425	4	3	5
11	R:R:N139	6.29833	6	3	5
12	R:R:W141	5.33286	7	3	9
13	R:R:F155	7.338	5	2	6
14	R:R:Y156	4.9575	4	2	5
15	R:R:Y160	9.2	4	0	7
16	R:R:C161	5.83	4	4	7
17	R:R:F165	8.92	4	4	7
18	R:R:M166	4.82	5	1	8
19	R:R:S170	4.8525	4	0	9
20	R:R:H183	9.9025	4	0	6
21	R:R:T225	5.052	5	3	4
22	R:R:D228	6.89	4	3	4
23	R:R:F240	6.3125	4	0	3
24	R:R:F243	8.936	5	2	6
25	R:R:F251	7.756	5	1	8
26	R:R:Y262	6.09	6	1	9
27	R:R:I286	4.58	4	0	6
28	R:R:L293	4.015	4	0	8
29	R:R:Y296	5.21	5	0	9
30	R:R:F300	8.366	5	1	9
31	R:R:L307	6.9125	4	2	5
32	R:R:H310	7.005	4	5	4
33	R:R:Y311	6.6925	4	2	5
34	R:R:S320	6.1175	4	5	2
35	R:R:Y323	5.4275	4	0	4
36	R:R:T334	7.2425	4	2	7
37	R:R:D340	5.82	5	1	9
38	R:R:Y344	5.985	6	1	9
39	R:R:Y345	7.328	5	1	7
40	R:R:F351	6.832	5	1	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F243	R:R:Y311	13.038	15.47	Yes	Yes	2	6	5
2	R:R:F243	R:R:Y156	60.9521	5.16	Yes	Yes	2	6	5
3	R:R:F155	R:R:Y156	60.1539	6.19	Yes	Yes	2	6	5
4	R:R:F155	R:R:Y82	52.8554	9.28	Yes	Yes	2	6	7
5	R:R:K131	R:R:Y82	56.2533	8.36	No	Yes	0	7	7
6	R:R:H135	R:R:K131	26.0716	6.55	No	No	0	5	7
7	R:R:H135	R:R:T74	24.4113	8.21	No	Yes	0	5	4
8	R:R:N139	R:R:T74	21.9086	7.31	Yes	Yes	0	5	4
9	R:R:D228	R:R:N139	15.587	5.39	Yes	Yes	3	4	5
10	R:R:D228	R:R:Y323	43.5593	4.6	Yes	Yes	0	4	4
11	R:R:L38	R:R:Y323	13.7524	5.86	No	Yes	0	8	4
12	R:R:K131	R:R:L151	30.9468	9.87	No	No	0	7	5
13	R:R:L151	R:R:W141	54.6569	3.42	No	Yes	0	5	9
14	R:R:W141	R:R:Y134	39.2904	9.65	Yes	Yes	3	9	5
15	R:R:D228	R:R:Y134	29.1189	10.34	Yes	Yes	3	4	5
16	R:R:H310	R:R:Y323	18.9407	7.62	Yes	Yes	0	4	4
17	R:R:I327	R:R:Y323	10.3237	3.63	No	Yes	0	4	4
18	R:R:F243	R:R:Y242	68.4358	9.28	Yes	No	0	6	5
19	R:R:L246	R:R:Y242	100	8.21	No	No	0	5	5
20	R:R:L246	R:R:Y160	99.806	18.76	No	Yes	0	5	7
21	R:R:N304	R:R:Y160	99.376	8.14	No	Yes	0	8	7
22	R:R:F251	R:R:N304	98.2537	19.33	Yes	No	0	8	8
23	R:R:F251	R:R:F300	96.5779	4.29	Yes	Yes	1	8	9
24	R:R:F300	R:R:M166	87.3104	3.73	Yes	Yes	1	9	8
25	R:R:L117	R:R:M166	28.1443	4.24	Yes	Yes	1	9	8
26	R:R:D121	R:R:N93	19.5559	13.46	Yes	No	1	9	9
27	R:R:N93	R:R:S92	15.6619	5.96	No	Yes	1	9	7
28	R:R:G89	R:R:S92	11.7856	3.71	No	Yes	0	8	7
29	R:R:D121	R:R:D340	15.5429	6.65	Yes	Yes	1	9	9
30	R:R:F300	R:R:N336	10.6699	10.87	Yes	No	0	9	9
31	R:R:F346	R:R:F351	11.1616	10.72	No	Yes	0	7	8
32	R:R:F351	R:R:Y345	20.2461	7.22	Yes	Yes	1	8	7
33	R:R:L117	R:R:Y345	21.5426	4.69	Yes	Yes	1	9	7
34	R:R:Y344	R:R:Y345	24.9471	3.97	Yes	Yes	1	9	7
35	R:R:M166	R:R:Y344	46.0046	7.18	Yes	Yes	1	8	9
36	R:R:M114	R:R:Y345	20.4048	8.38	No	Yes	1	8	7
37	R:R:L169	R:R:Y113	18.3189	4.69	No	Yes	0	8	7
38	R:R:L169	R:R:M114	19.6684	2.83	No	No	0	8	8
39	R:R:F154	R:R:Y210	32.9335	4.13	No	No	0	5	5
40	R:R:G153	R:R:Y210	33.8993	4.35	No	No	0	6	5
41	R:R:G153	R:R:L209	34.2741	3.42	No	No	0	6	4
42	R:R:L209	R:R:Y242	35.3612	15.24	No	No	0	4	5
43	R:R:L151	R:R:W127	27.7099	4.56	No	Yes	0	5	7
44	R:R:F154	R:R:W127	28.5765	15.03	No	Yes	0	5	7
45	R:R:M166	R:R:Y296	10.295	4.79	Yes	Yes	0	8	9
46	R:R:R173	R:R:Y344	20.4798	6.17	No	Yes	1	9	9
47	R:R:M265	R:R:R173	10.6081	3.72	No	No	1	8	9
48	R:R:M265	R:R:Y174	10.9631	2.39	No	No	0	8	8
49	R:R:I289	R:R:Y262	16.2308	7.25	No	Yes	0	8	9
50	R:R:I266	R:R:I289	14.7667	7.36	No	No	0	5	8
51	R:R:I266	R:R:I286	11.8319	8.83	No	Yes	0	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9D0A_nogp

PDB Summary
PDB	9D0A_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.42
Number of Linked Nodes	276
Number of Links	304
Number of Hubs	40
Number of Links mediated by Hubs	144
Number of Communities	7
Number of Nodes involved in Communities	55
Number of Links involved in Communities	74

Path Summary
Number Of Nodes in MetaPath	52
Number Of Links MetaPath	51
Number of Shortest Paths	68873
Length Of Smallest Path	3
Average Path Length	17.0713
Length of Longest Path	33
Minimum Path Strength	1.33
Average Path Strength	7.35899
Maximum Path Strength	18.045
Minimum Path Correlation	0.7
Average Path Correlation	0.934167
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	47.473
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.5646
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • G-protein alpha-subunit binding • molecular transducer activity • signaling receptor activity • signaling receptor binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • enzyme binding • protease binding • peptide receptor activity • thrombin-activated receptor activity • proteinase-activated receptor activity • G protein-coupled peptide receptor activity • multicellular organismal process • regulation of body fluid levels • wound healing • hemostasis • blood coagulation • response to stress • coagulation • regulation of biological quality • response to wounding • developmental process • myeloid leukocyte differentiation • cellular developmental process • hemopoiesis • cell development • mononuclear cell differentiation • myeloid cell differentiation • cell differentiation • anatomical structure development • dendritic cell differentiation • mature conventional dendritic cell differentiation • leukocyte differentiation • reactive oxygen species metabolic process • positive regulation of biological process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • positive regulation of cellular process • regulation of signaling • regulation of JNK cascade • regulation of signal transduction • regulation of MAPK cascade • intracellular signal transduction • regulation of intracellular signal transduction • regulation of response to stimulus • JNK cascade • intracellular signaling cassette • MAPK cascade • regulation of cell communication • regulation of cellular component organization • positive regulation of cellular component organization • cell projection organization • plasma membrane bounded cell projection assembly • cellular component biogenesis • cellular component organization • pseudopodium assembly • cellular component assembly • positive regulation of cell projection organization • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • positive regulation of cellular component biogenesis • regulation of cell projection organization • regulation of cell projection assembly • regulation of cellular component biogenesis • regulation of plasma membrane bounded cell projection assembly • positive regulation of pseudopodium assembly • regulation of pseudopodium assembly • cell projection assembly • regulation of plasma membrane bounded cell projection organization • positive regulation of plasma membrane bounded cell projection assembly • pseudopodium organization • chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • response to external stimulus • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • taxis • regulation of locomotion • locomotion • biological process involved in interspecies interaction between organisms • immune response • response to other organism • defense response • defense response to symbiont • response to biotic stimulus • immune system process • defense response to other organism • innate immune response • response to external biotic stimulus • positive regulation of cell communication • positive regulation of response to biotic stimulus • positive regulation of signal transduction • pattern recognition receptor signaling pathway • immune response-activating signaling pathway • positive regulation of toll-like receptor 3 signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • innate immune response-activating signaling pathway • positive regulation of pattern recognition receptor signaling pathway • regulation of innate immune response • positive regulation of intracellular signal transduction • regulation of pattern recognition receptor signaling pathway • positive regulation of defense response • regulation of immune response • activation of innate immune response • activation of immune response • regulation of defense response • cytoplasmic pattern recognition receptor signaling pathway • regulation of response to biotic stimulus • intracellular receptor signaling pathway • regulation of cytoplasmic pattern recognition receptor signaling pathway • endolysosomal toll-like receptor signaling pathway • immune response-regulating signaling pathway • regulation of response to stress • regulation of toll-like receptor 3 signaling pathway • positive regulation of innate immune response • toll-like receptor 3 signaling pathway • positive regulation of signaling • regulation of biosynthetic process • chemokine (C-X-C motif) ligand 2 production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of chemokine production • regulation of gene expression • regulation of chemokine (C-X-C motif) ligand 2 production • biosynthetic process • regulation of cytokine production • cytokine production • chemokine production • regulation of macromolecule biosynthetic process • regulation of multicellular organismal process • macromolecule metabolic process • negative regulation of biological process • negative regulation of chemokine production • negative regulation of cellular process • negative regulation of macromolecule metabolic process • negative regulation of metabolic process • negative regulation of cytokine production • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of multicellular organismal process • interleukin-1 production • regulation of interleukin-1 beta production • positive regulation of macromolecule biosynthetic process • positive regulation of interleukin-1 beta production • positive regulation of biosynthetic process • positive regulation of interleukin-1 production • positive regulation of macromolecule metabolic process • regulation of interleukin-1 production • interleukin-1 beta production • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of cytokine production • positive regulation of interleukin-8 production • interleukin-8 production • regulation of interleukin-8 production • positive regulation of JNK cascade • positive regulation of MAPK cascade • positive regulation of chemokine production • system process • renal system process • regulation of renal system process • regulation of blood pressure • regulation of system process • regulation of glomerular filtration • positive regulation of glomerular filtration • regulation of systemic arterial blood pressure • circulatory system process • renal system process involved in regulation of blood volume • renal system process involved in regulation of systemic arterial blood pressure • glomerular filtration • blood circulation • renal filtration • negative regulation of signaling • negative regulation of cytoplasmic pattern recognition receptor signaling pathway • negative regulation of intracellular signal transduction • negative regulation of cell communication • negative regulation of toll-like receptor 3 signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of immune system process • interleukin-10 production • regulation of interleukin-10 production • positive regulation of interleukin-10 production • regulation of systemic arterial blood pressure by renin-angiotensin • regulation of localization • regulation of systemic arterial blood pressure by hormone • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure • intracellular protein localization • establishment of protein localization to extracellular region • regulation of systemic arterial blood pressure by circulatory renin-angiotensin • protein secretion • establishment of localization • positive regulation of renin secretion into blood stream • regulation of protein secretion • regulation of secretion • positive regulation of protein localization • regulation of endocrine process • renin secretion into blood stream • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of protein localization • transport • positive regulation of secretion by cell • protein localization to extracellular region • positive regulation of protein transport • regulation of secretion by cell • secretion by cell • regulation of renin secretion into blood stream • positive regulation of secretion • signal release • regulation of transport • secretion • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • endocrine process • positive regulation of transport • protein transport • macromolecule localization • cell activation • lymphocyte activation • cell activation involved in immune response • leukocyte activation • immune effector process • T cell activation involved in immune response • T cell activation • leukocyte activation involved in immune response • lymphocyte activation involved in immune response • regulation of immune effector process • regulation of myeloid leukocyte mediated immunity • regulated exocytosis • positive regulation of leukocyte mediated immunity • leukocyte degranulation • myeloid leukocyte mediated immunity • vesicle-mediated transport • myeloid leukocyte activation • positive regulation of leukocyte degranulation • positive regulation of regulated secretory pathway • establishment of localization in cell • leukocyte mediated immunity • regulation of leukocyte mediated immunity • exocytosis • positive regulation of myeloid leukocyte mediated immunity • eosinophil mediated immunity • cellular localization • eosinophil activation • positive regulation of exocytosis • regulation of regulated secretory pathway • regulation of eosinophil degranulation • positive regulation of eosinophil degranulation • eosinophil degranulation • positive regulation of immune effector process • eosinophil activation involved in immune response • regulation of leukocyte degranulation • regulation of vesicle-mediated transport • myeloid cell activation involved in immune response • regulation of exocytosis • granulocyte activation • defense response to virus • response to virus • positive regulation of DNA-templated transcription • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • regulation of cell motility • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • cell chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • positive regulation of leukocyte migration • leukocyte migration • leukocyte chemotaxis • leukocyte proliferation • positive regulation of cytosolic calcium ion concentration • positive regulation of canonical NF-kappaB signal transduction • canonical NF-kappaB signal transduction • regulation of canonical NF-kappaB signal transduction • immune response-regulating cell surface receptor signaling pathway • cell surface toll-like receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • regulation of toll-like receptor 4 signaling pathway • positive regulation of toll-like receptor 4 signaling pathway • innate immune response activating cell surface receptor signaling pathway • cell surface pattern recognition receptor signaling pathway • cell surface receptor signaling pathway • toll-like receptor 4 signaling pathway • positive regulation of ERK1 and ERK2 cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • import into cell • positive regulation of membrane invagination • positive regulation of endocytosis • regulation of phagocytosis, engulfment • membrane invagination • phagocytosis • plasma membrane invagination • regulation of endocytosis • membrane organization • regulation of phagocytosis • phagocytosis, engulfment • positive regulation of phagocytosis • positive regulation of phagocytosis, engulfment • regulation of membrane invagination • endocytosis • positive regulation of organelle organization • regulation of cytoskeleton organization • regulation of actin filament-based process • regulation of cellular component size • protein-containing complex disassembly • positive regulation of actin filament depolymerization • regulation of protein-containing complex disassembly • actin filament depolymerization • regulation of actin filament depolymerization • actin filament-based process • positive regulation of protein-containing complex disassembly • cellular component disassembly • actin polymerization or depolymerization • regulation of actin filament organization • actin cytoskeleton organization • protein-containing complex organization • regulation of protein depolymerization • positive regulation of protein depolymerization • positive regulation of cytoskeleton organization • actin filament organization • regulation of actin polymerization or depolymerization • positive regulation of supramolecular fiber organization • regulation of organelle organization • organelle organization • regulation of actin filament length • regulation of actin cytoskeleton organization • regulation of supramolecular fiber organization • supramolecular fiber organization • protein depolymerization • cytoskeleton organization • regulation of anatomical structure size • interleukin-6 production • positive regulation of interleukin-6 production • regulation of interleukin-6 production • neutrophil-mediated killing of symbiont cell • regulation of killing of cells of another organism • disruption of cell in another organism • regulation of programmed cell death • positive regulation of neutrophil mediated cytotoxicity • positive regulation of leukocyte mediated cytotoxicity • response to bacterium • positive regulation of neutrophil mediated killing of symbiont cell • regulation of neutrophil mediated killing of gram-negative bacterium • biological process involved in interaction with symbiont • killing of cells of another organism • positive regulation of programmed cell death • leukocyte mediated cytotoxicity • cell death • positive regulation of neutrophil mediated killing of bacterium • regulation of cell killing • positive regulation of cell killing • disruption of anatomical structure in another organism • positive regulation of killing of cells of another organism • positive regulation of neutrophil mediated killing of gram-negative bacterium • defense response to Gram-negative bacterium • biological process involved in symbiotic interaction • regulation of neutrophil mediated killing of bacterium • defense response to bacterium • positive regulation of defense response to bacterium • neutrophil mediated immunity • modulation of process of another organism • regulation of biological process involved in symbiotic interaction • regulation of defense response to bacterium • neutrophil-mediated killing of bacterium • neutrophil mediated cytotoxicity • regulation of neutrophil mediated cytotoxicity • regulation of leukocyte mediated cytotoxicity • regulation of neutrophil mediated killing of symbiont cell • killing by host of symbiont cells • neutrophil-mediated killing of gram-negative bacterium • programmed cell death • cell killing • positive regulation of molecular function • regulation of molecular function • positive regulation of hydrolase activity • regulation of catalytic activity • regulation of hydrolase activity • positive regulation of catalytic activity • regulation of GTPase activity • positive regulation of GTPase activity • neutrophil activation • regulation of toll-like receptor 2 signaling pathway • positive regulation of toll-like receptor 2 signaling pathway • toll-like receptor 2 signaling pathway • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • positive regulation of small GTPase mediated signal transduction • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • negative regulation of establishment of protein localization • negative regulation of protein secretion • regulation of hormone secretion • regulation of peptide secretion • hormone secretion • negative regulation of peptide secretion • peptide secretion • amide transport • negative regulation of protein localization • regulation of peptide transport • peptide transport • negative regulation of insulin secretion • regulation of insulin secretion • peptide hormone secretion • hormone transport • insulin secretion • negative regulation of JNK cascade • negative regulation of MAPK cascade • regulation of tube diameter • regulation of tube size • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • positive chemotaxis • positive regulation of positive chemotaxis • regulation of positive chemotaxis • epithelium development • endothelial cell differentiation • endothelium development • tissue development • epithelial cell differentiation • endothelial cell development • epithelial cell development • establishment of endothelial barrier • cell junction maintenance • cell junction organization • cellular component maintenance • cell-cell junction maintenance • cell-cell junction organization • inflammatory response • regulation of blood coagulation • regulation of coagulation • regulation of response to wounding • regulation of wound healing • regulation of hemostasis • cytokine production involved in immune response • production of molecular mediator of immune response • regulation of cytokine production involved in immune response • positive regulation of cytokine production involved in immune response • positive regulation of production of molecular mediator of immune response • regulation of production of molecular mediator of immune response • response to cytokine • cytokine-mediated signaling pathway • cellular response to tumor necrosis factor • tumor necrosis factor-mediated signaling pathway • cellular response to cytokine stimulus • regulation of tumor necrosis factor-mediated signaling pathway • regulation of cytokine-mediated signaling pathway • negative regulation of tumor necrosis factor-mediated signaling pathway • response to peptide • regulation of response to cytokine stimulus • negative regulation of response to cytokine stimulus • negative regulation of cytokine-mediated signaling pathway • response to tumor necrosis factor • regulation of type II interferon production • type II interferon production • positive regulation of type II interferon production • pseudopodium • Golgi apparatus • endomembrane system • early endosome • endosome • intracellular vesicle • cytoplasmic vesicle • GTPase regulator activity • enzyme regulator activity • enzyme activator activity • GTPase activator activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • G protein-coupled receptor binding • cation binding • metal ion binding • D1 dopamine receptor binding • dopamine receptor binding • cyclase regulator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • regulation of Wnt signaling pathway • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • Wnt signaling pathway • neuropeptide signaling pathway • regulation of protein stability • protein stabilization • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • rhythmic process • entrainment of circadian clock • circadian rhythm • regulation of circadian rhythm • glutamate receptor signaling pathway • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to abiotic stimulus • response to radiation • phototransduction, visible light • regulation of cell activation • regulation of platelet activation • platelet activation • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • multicellular organism development • skeletal system development • bone development • system development • homotypic cell-cell adhesion • platelet aggregation • cell adhesion • cell-cell adhesion • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • intracellular transport • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • negative regulation of inflammatory response to antigenic stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • negative regulation of response to external stimulus • negative regulation of defense response • positive regulation of adenylate cyclase activity • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • positive regulation of lyase activity • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • nuclear membrane • nucleus • organelle envelope • nuclear envelope • cytosolic region • postsynapse • postsynaptic cytosol • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P55085
Sequence	>9D0A_nogp_Chain_R S L I D E F S A S V L T G K L T T V F L P I V Y T I V F V V G L P S N G M A L W V F L F R T K K K H P A V I Y M A N L A L A D L L S V I W F P L K I A Y H I H G N N W I Y G E A L C N V L I G F F Y G N M Y C S I L F M T C L S V Q R Y W V I V N P M G H S R K K A N I A I G I S L A I W L L I L L V T I P L Y V V K Q T I F I P A L N I T T C H D V L P E Q L L V G D M F N Y F L S L A I G V F L F P A F L T A S A Y V L M I R M L R S S A M D E N S E K K R K R A I K L I V T V L A M Y L I C F T P S N L L L V V H Y F L I K S Q G Q S H V Y A L Y I V A L C L S T L N S C I D P F V Y Y F V S H D F R D H A K N A L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5NDD	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	AZ8838; Na	-	2.8	2017-05-03	doi.org/10.1038/nature22309
	5NDZ	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	AZ3451; Na	-	3.6	2017-05-03	doi.org/10.1038/nature22309
	5NJ6	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-	-	4	2017-05-03	doi.org/10.1038/nature22309
	9D0A	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.1	2025-05-07	doi.org/10.1038/s41467-025-59138-x
	9D0A (No Gprot)	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-		3.1	2025-05-07	doi.org/10.1038/s41467-025-59138-x
	9E7R	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	GB88	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.18	2025-05-07	doi.org/10.1038/s41467-025-59138-x
	9E7R (No Gprot)	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	GB88	-		3.18	2025-05-07	doi.org/10.1038/s41467-025-59138-x
	8ZMD	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.25	2025-05-28	To be published
	8ZMD (No Gprot)	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-		3.25	2025-05-28	To be published
	8ZME	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.2	2025-05-28	To be published
	8ZME (No Gprot)	A	Peptide	Proteinase Activated	PAR2	Homo sapiens	-	-		3.2	2025-05-28	To be published

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