Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L41 6.2225455
2A:A:K42 4.2675419
3A:A:L44 6.215419
4A:A:L45 5.976558
5A:A:S51 3.6075409
6A:A:K53 6.1425409
7A:A:F56 6.025657
8A:A:F219 6.83167658
9A:A:M221 4.272558
10A:A:F222 8.738517
11A:A:K233 6.822519
12A:A:W234 6.978519
13A:A:F238 5.68167619
14A:A:N239 5.9475418
15A:A:I244 4.37333618
16A:A:I245 3.7025457
17A:A:F246 5.64519
18A:A:V247 4.23557
19A:A:Y253 7.62518
20A:A:R265 6.23409
21A:A:F273 5.39429719
22A:A:I276 3.49418
23A:A:W277 8.475816
24A:A:W281 7.12857715
25A:A:I288 4.61459
26A:A:L289 4.844519
27A:A:F290 4.1525859
28A:A:L291 3.2325418
29A:A:N292 4.316559
30A:A:I308 6.335417
31A:A:F312 3.075618
32A:A:F315 8.3416
33A:A:Y318 4.8625416
34A:A:V334 2.486504
35A:A:Y339 5.888513
36A:A:F340 6.59517
37A:A:I341 3.9025418
38A:A:F345 5.06167618
39A:A:G353 2.858514
40A:A:C359 3.682515
41A:A:Y360 8.69167658
42A:A:F363 10.408515
43A:A:T364 5.7175459
44A:A:D368 4.2375459
45A:A:N371 5.6475459
46A:A:R374 10.56454
47A:A:F376 5.518558
48A:A:D378 6.6225457
49A:A:E390 7.925424
50A:A:Y391 7.95857724
51A:A:L393 5.5175408
52B:B:M45 6.6825434
53B:B:L51 6.775439
54B:B:H54 7.58167639
55B:B:K57 12.534519
56B:B:Y59 10.09518
57B:B:M61 3.592536
58B:B:W63 8.67333637
59B:B:L69 6.22435
60B:B:L70 8.155435
61B:B:V71 5.008538
62B:B:L79 4.452537
63B:B:I80 12.5525438
64B:B:I81 5.474537
65B:B:W82 5.875839
66B:B:D83 5.078538
67B:B:S84 4.545435
68B:B:Y85 11.7225434
69B:B:N88 6.162537
70B:B:K89 12.144539
71B:B:H91 6.0275435
72B:B:I93 6.0075437
73B:B:L95 4.3325438
74B:B:W99 6.87625819
75B:B:M101 3.588519
76B:B:C103 3.424538
77B:B:Y105 5.79375836
78B:B:N110 5.5175414
79B:B:Y111 4.46614
80B:B:V112 5.905438
81B:B:A113 2.3925419
82B:B:C114 2.92833638
83B:B:G115 2.3275409
84B:B:L117 4.08167619
85B:B:C121 2.9425418
86B:B:I123 4.3375416
87B:B:Y124 5.86857736
88B:B:T128 6.1325413
89B:B:V133 5.715434
90B:B:R137 12.9225415
91B:B:L139 12.2625419
92B:B:H142 6.70571719
93B:B:Y145 5.5275818
94B:B:L146 4.38417
95B:B:C149 3.4725418
96B:B:F151 4.35619
97B:B:L152 4.264563
98B:B:I157 3.6875417
99B:B:V158 5.275465
100B:B:T159 4.668519
101B:B:S160 5.95466
102B:B:S161 6.8875419
103B:B:D163 8.045419
104B:B:C166 3.655668
105B:B:W169 9.73571718
106B:B:Q176 6.5475414
107B:B:F180 8.48567
108B:B:H183 9.06571769
109B:B:V187 6.748569
110B:B:L190 6.3875465
111B:B:L192 3.6325465
112B:B:A193 3.46444
113B:B:F199 6.02769
114B:B:S201 4.616569
115B:B:D205 5.472569
116B:B:S207 5.3375465
117B:B:K209 8.60429766
118B:B:W211 10.04668
119B:B:R219 6.222585
120B:B:F222 6.962548
121B:B:H225 8.08429749
122B:B:I232 5.316548
123B:B:F234 6.006545
124B:B:F235 7.58125846
125B:B:P236 5.495447
126B:B:N237 6.3925445
127B:B:G238 3.1025447
128B:B:F241 6.53286746
129B:B:T243 6.945448
130B:B:D247 7.336549
131B:B:T249 6.1075446
132B:B:R251 8.114548
133B:B:F253 7.66646
134B:B:D254 6.9875449
135B:B:L255 4.3475406
136B:B:Y264 6.05667645
137B:B:I269 5.04444
138B:B:V276 2.8575406
139B:B:F278 5.34286747
140B:B:G282 3.648549
141B:B:R283 5.224539
142B:B:L284 4.23833635
143B:B:L285 4.746546
144B:B:L286 3.5925437
145B:B:Y289 7.78833647
146B:B:D290 7.202516
147B:B:D291 6.7425448
148B:B:V296 3.8125435
149B:B:W297 12.504548
150B:B:R304 12.13445
151B:B:V307 4.935443
152B:B:H311 9.342539
153B:B:R314 12.0783618
154B:B:V315 3.9325437
155B:B:C317 3.4407
156B:B:T321 6.838537
157B:B:G324 2.295409
158B:B:V327 4.385406
159B:B:T329 4.57538
160B:B:G330 3.1225435
161B:B:W332 12.4371719
162B:B:L336 3.21857737
163B:B:K337 9.6025436
164B:B:I338 5.01535
165B:B:W339 7.665639
166B:B:N340 6.125439
167G:G:Y40 7.516546
168G:G:H44 7.125446
169G:G:D48 4.965409
170G:G:L51 4.95436
171G:G:P60 7.795439
172G:G:F61 5.78375838
173R:R:S37 6.1325428
174R:R:T74 4.64474
175R:R:Y82 7.82833627
176R:R:F86 4.98426
177R:R:G89 2.3425428
178R:R:S92 5.305427
179R:R:N93 8.8429
180R:R:F100 5.96143726
181R:R:H108 8.26527
182R:R:I112 3.74426
183R:R:Y113 5.86667627
184R:R:M114 5.41428
185R:R:L117 4.00167629
186R:R:D121 6.604529
187R:R:L122 3.355408
188R:R:W127 8.805427
189R:R:F128 8.556528
190R:R:Y134 5.97333675
191R:R:H135 5.118575
192R:R:N139 5.76286775
193R:R:W141 5.0275879
194R:R:Y143 6.6575477
195R:R:F154 6.052525
196R:R:F155 7.338526
197R:R:Y156 4.62525
198R:R:N158 6.625428
199R:R:Y160 9.2427
200R:R:C161 5.83427
201R:R:F165 7.624527
202R:R:M166 4.48333628
203R:R:L169 3.13428
204R:R:S170 4.8525429
205R:R:Q172 6.495428
206R:R:R173 7.6125429
207R:R:Y174 6.895408
208R:R:I177 3.94498
209R:R:H183 8.358526
210R:R:S195 4.5925427
211R:R:W199 6.18667629
212R:R:T206 2.64427
213R:R:L209 6.4775424
214R:R:Y210 3.3075405
215R:R:V212 4.895404
216R:R:T225 5.052574
217R:R:C226 5.27479
218R:R:H227 5.096525
219R:R:D228 6.89474
220R:R:L230 5.05625
221R:R:L235 5.17424
222R:R:M239 4.32524
223R:R:F240 6.3125403
224R:R:Y242 8.8075425
225R:R:F243 8.01167626
226R:R:L246 7.86425
227R:R:F251 6.80667628
228R:R:Y262 5.12875829
229R:R:M265 3.755428
230R:R:K281 6.2175405
231R:R:I289 5.4525428
232R:R:L293 4.015408
233R:R:Y296 4.36143729
234R:R:C299 3.875429
235R:R:F300 6.72729
236R:R:N304 8.59428
237R:R:L307 6.9125425
238R:R:H310 6.04524
239R:R:Y311 4.84725
240R:R:S320 6.1175422
241R:R:Y323 4.938504
242R:R:Y326 6.0875404
243R:R:L330 3.312525
244R:R:S333 4.8428
245R:R:T334 7.2425427
246R:R:N336 8.4725429
247R:R:D340 5.82529
248R:R:V343 3.66428
249R:R:Y344 5.03829
250R:R:Y345 6.01286727
251R:R:F351 6.832528
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:S316 B:B:W332 17.51184.94NoYes099
2B:B:C317 B:B:S316 17.43963.44YesNo079
3B:B:L117 B:B:M101 16.39922.83YesYes199
4B:B:G116 B:B:M101 23.4613.49NoYes099
5B:B:G115 B:B:G116 23.05762.11YesNo099
6B:B:C114 B:B:G115 21.13051.96YesYes089
7R:R:V343 R:R:Y344 89.24565.05YesYes289
8R:R:V343 R:R:V347 94.82143.21YesNo287
9R:R:R284 R:R:V347 953.92NoNo277
10A:A:V394 R:R:R284 95.40046.54NoNo087
11A:A:V394 R:R:K281 95.59323.04NoYes085
12A:A:Q385 R:R:K281 96.171510.85NoYes055
13A:A:D381 A:A:Q385 96.74919.14NoNo085
14A:A:D381 A:A:Y360 48.862411.49NoYes588
15A:A:D378 A:A:Y360 48.68039.2YesYes578
16A:A:D378 A:A:I288 48.62497YesYes579
17A:A:F290 A:A:I288 48.38613.77YesYes599
18A:A:F290 A:A:V247 95.61596.55YesYes597
19A:A:S51 A:A:V247 99.60883.23YesYes097
20A:A:S51 A:A:T48 1001.6YesNo097
21A:A:D272 A:A:T48 98.51222.89NoNo087
22A:A:D272 A:A:I276 93.00732.8NoYes188
23A:A:I244 A:A:I276 55.4822.94YesYes188
24A:A:I244 A:A:L282 17.61435.71YesNo189
25A:A:L282 A:A:N279 17.46028.24NoNo198
26A:A:N279 A:A:W281 17.41953.39NoYes185
27A:A:W281 B:B:W332 16.62491.87YesYes159
28A:A:D381 R:R:D275 48.07916.65NoNo584
29A:A:D378 R:R:D275 48.16753.99YesNo574
30A:A:D378 A:A:H362 48.29676.3YesNo579
31A:A:F290 A:A:H362 48.22893.39YesNo599
32A:A:L44 A:A:W234 65.58843.42YesYes199
33A:A:F238 A:A:L44 12.44186.09YesYes199
34A:A:W234 B:B:Y145 56.90815.79YesYes198
35B:B:S147 B:B:Y145 35.2292.54NoYes098
36B:B:S147 B:B:S160 35.1044.89NoYes096
37A:A:L44 A:A:L46 38.153211.07YesNo198
38R:R:Y344 R:R:Y345 15.47993.97YesYes297
39B:B:C317 B:B:G330 11.48241.96YesYes075
40B:B:G162 B:B:S161 13.37421.86NoYes199
41B:B:S160 B:B:V187 13.70836.46YesYes669
42B:B:C166 B:B:S201 10.37283.44YesYes689
43B:B:G202 B:B:S201 20.17341.86NoYes069
44B:B:G202 B:B:S189 12.72891.86NoNo067
45B:B:I232 B:B:S189 12.45657.74YesNo087
46R:R:M166 R:R:Y344 46.11057.18YesYes289
47R:R:F300 R:R:M166 35.44123.73YesYes298
48R:R:F300 R:R:S333 29.70216.61YesYes298
49R:R:L330 R:R:S333 29.07433YesYes258
50R:R:L330 R:R:Y156 17.76983.52YesYes255
51R:R:L330 R:R:Y82 10.29132.34YesYes257
52R:R:D340 R:R:Y344 12.60353.45YesYes299
53R:R:F165 R:R:L117 15.88012.44YesYes279
54A:A:I276 A:A:L46 38.20045.71YesNo188
55A:A:I244 A:A:L44 39.9524.28YesYes189
56B:B:G162 B:B:Y145 13.502310.14NoYes198
57B:B:C166 B:B:S160 15.99083.44YesYes686
58B:B:S201 B:B:V187 10.11533.23YesYes699
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9D0A
Class A
SubFamily Peptide
Type Proteinase Activated
SubType PAR2
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1L-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 3.1
Date 2025-05-07
D.O.I. doi.org/10.1038/s41467-025-59138-x
Net Summary
Imin 1.74
Number of Linked Nodes 801
Number of Links 1157
Number of Hubs 251
Number of Links mediated by Hubs 857
Number of Communities 10
Number of Nodes involved in Communities 369
Number of Links involved in Communities 635
Path Summary
Number Of Nodes in MetaPath 59
Number Of Links MetaPath 58
Number of Shortest Paths 3742142
Length Of Smallest Path 3
Average Path Length 29.7605
Length of Longest Path 49
Minimum Path Strength 1.44
Average Path Strength 5.14918
Maximum Path Strength 24.18
Minimum Path Correlation 0.7
Average Path Correlation 0.987624
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.77778
Average % Of Corr. Nodes 34.7042
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 62.6446
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • GTPase regulator activity   • enzyme regulator activity   • enzyme activator activity   • GTPase activator activity   • molecular function activator activity   • nucleoside-triphosphatase regulator activity   • molecular function regulator activity   • binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • cation binding   • metal ion binding   • D1 dopamine receptor binding   • dopamine receptor binding   • cyclase regulator activity   • cyclase activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cellular response to stimulus   • regulation of biological process   • regulation of signaling   • regulation of cellular process   • cell surface receptor signaling pathway   • response to stimulus   • regulation of Wnt signaling pathway   • signaling   • regulation of canonical Wnt signaling pathway   • canonical Wnt signaling pathway   • biological regulation   • regulation of signal transduction   • cell communication   • regulation of response to stimulus   • regulation of cell communication   • cellular process   • signal transduction   • Wnt signaling pathway   • G protein-coupled receptor signaling pathway   • neuropeptide signaling pathway   • multicellular organismal process   • regulation of body fluid levels   • wound healing   • hemostasis   • blood coagulation   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • regulation of protein stability   • protein stabilization   • phospholipase C-activating serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • phospholipase C-activating G protein-coupled receptor signaling pathway   • rhythmic process   • entrainment of circadian clock   • circadian rhythm   • response to external stimulus   • regulation of circadian rhythm   • glutamate receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to alcohol   • response to prostaglandin E   • response to oxygen-containing compound   • detection of light stimulus   • response to light stimulus   • phototransduction   • detection of external stimulus   • detection of visible light   • detection of abiotic stimulus   • detection of stimulus   • response to abiotic stimulus   • response to radiation   • phototransduction, visible light   • cell activation   • regulation of cell activation   • regulation of platelet activation   • regulation of multicellular organismal process   • platelet activation   • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway   • G protein-coupled glutamate receptor signaling pathway   • cellular response to nitrogen compound   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • response to nitrogen compound   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • developmental process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • homotypic cell-cell adhesion   • platelet aggregation   • cell adhesion   • cell-cell adhesion   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • cellular response to ketone   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • regulation of inflammatory response   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • intracellular anatomical structure   • nuclear membrane   • nucleus   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • organelle envelope   • nuclear envelope   • organelle membrane   • cytoplasm   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • Golgi apparatus   • cytosolic region   • postsynapse   • postsynaptic cytosol   • cytosol   • Golgi apparatus subcompartment   • organelle subcompartment   • trans-Golgi network membrane   • trans-Golgi network   • G-protein alpha-subunit binding   • molecular transducer activity   • signaling receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • enzyme binding   • protease binding   • peptide receptor activity   • thrombin-activated receptor activity   • proteinase-activated receptor activity   • G protein-coupled peptide receptor activity   • G-protein beta-subunit binding   • myeloid leukocyte differentiation   • cellular developmental process   • hemopoiesis   • cell development   • mononuclear cell differentiation   • myeloid cell differentiation   • cell differentiation   • dendritic cell differentiation   • mature conventional dendritic cell differentiation   • leukocyte differentiation   • reactive oxygen species metabolic process   • regulation of superoxide metabolic process   • positive regulation of reactive oxygen species metabolic process   • superoxide metabolic process   • superoxide anion generation   • positive regulation of superoxide anion generation   • regulation of superoxide anion generation   • regulation of reactive oxygen species metabolic process   • regulation of JNK cascade   • regulation of MAPK cascade   • intracellular signal transduction   • regulation of intracellular signal transduction   • JNK cascade   • intracellular signaling cassette   • MAPK cascade   • regulation of cellular component organization   • positive regulation of cellular component organization   • cell projection organization   • plasma membrane bounded cell projection assembly   • cellular component biogenesis   • cellular component organization   • pseudopodium assembly   • cellular component assembly   • positive regulation of cell projection organization   • cellular component organization or biogenesis   • plasma membrane bounded cell projection organization   • positive regulation of cellular component biogenesis   • regulation of cell projection organization   • regulation of cell projection assembly   • regulation of cellular component biogenesis   • regulation of plasma membrane bounded cell projection assembly   • positive regulation of pseudopodium assembly   • regulation of pseudopodium assembly   • cell projection assembly   • regulation of plasma membrane bounded cell projection organization   • positive regulation of plasma membrane bounded cell projection assembly   • pseudopodium organization   • chemotaxis   • positive regulation of locomotion   • regulation of chemotaxis   • positive regulation of chemotaxis   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • taxis   • regulation of locomotion   • locomotion   • biological process involved in interspecies interaction between organisms   • response to other organism   • defense response to symbiont   • response to biotic stimulus   • defense response to other organism   • innate immune response   • response to external biotic stimulus   • positive regulation of cell communication   • positive regulation of response to biotic stimulus   • positive regulation of signal transduction   • pattern recognition receptor signaling pathway   • immune response-activating signaling pathway   • positive regulation of toll-like receptor 3 signaling pathway   • positive regulation of immune response   • positive regulation of immune system process   • innate immune response-activating signaling pathway   • positive regulation of pattern recognition receptor signaling pathway   • regulation of innate immune response   • positive regulation of intracellular signal transduction   • regulation of pattern recognition receptor signaling pathway   • positive regulation of defense response   • activation of innate immune response   • activation of immune response   • cytoplasmic pattern recognition receptor signaling pathway   • regulation of response to biotic stimulus   • intracellular receptor signaling pathway   • regulation of cytoplasmic pattern recognition receptor signaling pathway   • endolysosomal toll-like receptor signaling pathway   • immune response-regulating signaling pathway   • regulation of toll-like receptor 3 signaling pathway   • positive regulation of innate immune response   • toll-like receptor 3 signaling pathway   • positive regulation of signaling   • regulation of biosynthetic process   • chemokine (C-X-C motif) ligand 2 production   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • regulation of chemokine production   • regulation of gene expression   • regulation of chemokine (C-X-C motif) ligand 2 production   • biosynthetic process   • regulation of cytokine production   • cytokine production   • chemokine production   • regulation of macromolecule biosynthetic process   • macromolecule metabolic process   • negative regulation of chemokine production   • negative regulation of cellular process   • negative regulation of macromolecule metabolic process   • negative regulation of metabolic process   • negative regulation of cytokine production   • negative regulation of gene expression   • negative regulation of biosynthetic process   • negative regulation of macromolecule biosynthetic process   • negative regulation of multicellular organismal process   • interleukin-1 production   • regulation of interleukin-1 beta production   • positive regulation of macromolecule biosynthetic process   • positive regulation of interleukin-1 beta production   • positive regulation of biosynthetic process   • positive regulation of interleukin-1 production   • positive regulation of macromolecule metabolic process   • regulation of interleukin-1 production   • interleukin-1 beta production   • positive regulation of gene expression   • positive regulation of cytokine production   • positive regulation of interleukin-8 production   • interleukin-8 production   • regulation of interleukin-8 production   • positive regulation of JNK cascade   • positive regulation of MAPK cascade   • positive regulation of chemokine production   • regulation of renal system process   • regulation of blood pressure   • regulation of system process   • regulation of glomerular filtration   • positive regulation of glomerular filtration   • regulation of systemic arterial blood pressure   • circulatory system process   • renal system process involved in regulation of blood volume   • renal system process involved in regulation of systemic arterial blood pressure   • glomerular filtration   • blood circulation   • renal filtration   • negative regulation of signaling   • negative regulation of cytoplasmic pattern recognition receptor signaling pathway   • negative regulation of intracellular signal transduction   • negative regulation of cell communication   • negative regulation of toll-like receptor 3 signaling pathway   • negative regulation of signal transduction   • interleukin-10 production   • regulation of interleukin-10 production   • positive regulation of interleukin-10 production   • regulation of systemic arterial blood pressure by renin-angiotensin   • regulation of systemic arterial blood pressure by hormone   • positive regulation of establishment of protein localization   • renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure   • regulation of systemic arterial blood pressure by circulatory renin-angiotensin   • positive regulation of renin secretion into blood stream   • positive regulation of protein localization   • regulation of endocrine process   • renin secretion into blood stream   • regulation of systemic arterial blood pressure mediated by a chemical signal   • positive regulation of secretion by cell   • positive regulation of protein transport   • regulation of renin secretion into blood stream   • positive regulation of secretion   • positive regulation of protein secretion   • endocrine process   • positive regulation of transport   • lymphocyte activation   • cell activation involved in immune response   • leukocyte activation   • immune effector process   • T cell activation involved in immune response   • T cell activation   • leukocyte activation involved in immune response   • lymphocyte activation involved in immune response   • regulation of immune effector process   • regulation of myeloid leukocyte mediated immunity   • regulated exocytosis   • positive regulation of leukocyte mediated immunity   • leukocyte degranulation   • myeloid leukocyte mediated immunity   • vesicle-mediated transport   • myeloid leukocyte activation   • positive regulation of leukocyte degranulation   • positive regulation of regulated secretory pathway   • leukocyte mediated immunity   • regulation of leukocyte mediated immunity   • exocytosis   • positive regulation of myeloid leukocyte mediated immunity   • eosinophil mediated immunity   • eosinophil activation   • positive regulation of exocytosis   • regulation of regulated secretory pathway   • regulation of eosinophil degranulation   • positive regulation of eosinophil degranulation   • eosinophil degranulation   • positive regulation of immune effector process   • eosinophil activation involved in immune response   • regulation of leukocyte degranulation   • regulation of vesicle-mediated transport   • myeloid cell activation involved in immune response   • regulation of exocytosis   • granulocyte activation   • defense response to virus   • response to virus   • positive regulation of DNA-templated transcription   • RNA metabolic process   • regulation of primary metabolic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • nucleic acid biosynthetic process   • DNA-templated transcription   • regulation of RNA metabolic process   • transcription by RNA polymerase II   • regulation of nucleobase-containing compound metabolic process   • regulation of RNA biosynthetic process   • regulation of transcription by RNA polymerase II   • primary metabolic process   • positive regulation of transcription by RNA polymerase II   • nucleobase-containing compound biosynthetic process   • nucleic acid metabolic process   • positive regulation of RNA metabolic process   • positive regulation of RNA biosynthetic process   • regulation of DNA-templated transcription   • regulation of cell motility   • positive regulation of cell migration   • positive regulation of cell motility   • regulation of cell migration   • cell migration   • cell motility   • cell chemotaxis   • regulation of leukocyte chemotaxis   • regulation of leukocyte migration   • positive regulation of leukocyte chemotaxis   • positive regulation of leukocyte migration   • leukocyte migration   • leukocyte chemotaxis   • cell population proliferation   • leukocyte proliferation   • positive regulation of cytosolic calcium ion concentration   • positive regulation of canonical NF-kappaB signal transduction   • canonical NF-kappaB signal transduction   • regulation of canonical NF-kappaB signal transduction   • immune response-regulating cell surface receptor signaling pathway   • cell surface toll-like receptor signaling pathway   • immune response-activating cell surface receptor signaling pathway   • regulation of toll-like receptor 4 signaling pathway   • positive regulation of toll-like receptor 4 signaling pathway   • innate immune response activating cell surface receptor signaling pathway   • cell surface pattern recognition receptor signaling pathway   • toll-like receptor 4 signaling pathway   • positive regulation of ERK1 and ERK2 cascade   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • import into cell   • positive regulation of membrane invagination   • positive regulation of endocytosis   • regulation of phagocytosis, engulfment   • membrane invagination   • phagocytosis   • plasma membrane invagination   • regulation of endocytosis   • membrane organization   • regulation of phagocytosis   • phagocytosis, engulfment   • positive regulation of phagocytosis   • positive regulation of phagocytosis, engulfment   • regulation of membrane invagination   • endocytosis   • positive regulation of organelle organization   • regulation of cytoskeleton organization   • regulation of actin filament-based process   • regulation of cellular component size   • protein-containing complex disassembly   • positive regulation of actin filament depolymerization   • regulation of protein-containing complex disassembly   • actin filament depolymerization   • regulation of actin filament depolymerization   • actin filament-based process   • positive regulation of protein-containing complex disassembly   • cellular component disassembly   • actin polymerization or depolymerization   • regulation of actin filament organization   • actin cytoskeleton organization   • protein-containing complex organization   • regulation of protein depolymerization   • positive regulation of protein depolymerization   • positive regulation of cytoskeleton organization   • actin filament organization   • regulation of actin polymerization or depolymerization   • positive regulation of supramolecular fiber organization   • regulation of organelle organization   • organelle organization   • regulation of actin filament length   • regulation of actin cytoskeleton organization   • regulation of supramolecular fiber organization   • supramolecular fiber organization   • protein depolymerization   • cytoskeleton organization   • regulation of anatomical structure size   • interleukin-6 production   • positive regulation of interleukin-6 production   • regulation of interleukin-6 production   • neutrophil-mediated killing of symbiont cell   • regulation of killing of cells of another organism   • disruption of cell in another organism   • regulation of programmed cell death   • positive regulation of neutrophil mediated cytotoxicity   • positive regulation of leukocyte mediated cytotoxicity   • response to bacterium   • positive regulation of neutrophil mediated killing of symbiont cell   • regulation of neutrophil mediated killing of gram-negative bacterium   • biological process involved in interaction with symbiont   • killing of cells of another organism   • positive regulation of programmed cell death   • leukocyte mediated cytotoxicity   • cell death   • positive regulation of neutrophil mediated killing of bacterium   • regulation of cell killing   • positive regulation of cell killing   • disruption of anatomical structure in another organism   • positive regulation of killing of cells of another organism   • positive regulation of neutrophil mediated killing of gram-negative bacterium   • defense response to Gram-negative bacterium   • biological process involved in symbiotic interaction   • regulation of neutrophil mediated killing of bacterium   • defense response to bacterium   • positive regulation of defense response to bacterium   • neutrophil mediated immunity   • modulation of process of another organism   • regulation of biological process involved in symbiotic interaction   • regulation of defense response to bacterium   • neutrophil-mediated killing of bacterium   • neutrophil mediated cytotoxicity   • regulation of neutrophil mediated cytotoxicity   • regulation of leukocyte mediated cytotoxicity   • regulation of neutrophil mediated killing of symbiont cell   • killing by host of symbiont cells   • neutrophil-mediated killing of gram-negative bacterium   • programmed cell death   • cell killing   • positive regulation of hydrolase activity   • regulation of hydrolase activity   • regulation of GTPase activity   • positive regulation of GTPase activity   • neutrophil activation   • regulation of toll-like receptor 2 signaling pathway   • positive regulation of toll-like receptor 2 signaling pathway   • toll-like receptor 2 signaling pathway   • small GTPase-mediated signal transduction   • regulation of small GTPase mediated signal transduction   • Rho protein signal transduction   • regulation of Rho protein signal transduction   • positive regulation of Rho protein signal transduction   • positive regulation of small GTPase mediated signal transduction   • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • phosphatidylinositol 3-kinase/protein kinase B signal transduction   • negative regulation of protein transport   • negative regulation of transport   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • negative regulation of peptide hormone secretion   • negative regulation of establishment of protein localization   • negative regulation of protein secretion   • negative regulation of peptide secretion   • negative regulation of protein localization   • negative regulation of insulin secretion   • negative regulation of JNK cascade   • negative regulation of MAPK cascade   • regulation of tube diameter   • regulation of tube size   • vascular process in circulatory system   • blood vessel diameter maintenance   • vasodilation   • positive chemotaxis   • positive regulation of positive chemotaxis   • regulation of positive chemotaxis   • endothelial cell differentiation   • endothelium development   • epithelial cell differentiation   • endothelial cell development   • epithelial cell development   • establishment of endothelial barrier   • cell junction maintenance   • cell junction organization   • cellular component maintenance   • cell-cell junction maintenance   • cell-cell junction organization   • regulation of blood coagulation   • regulation of coagulation   • regulation of response to wounding   • regulation of wound healing   • regulation of hemostasis   • cytokine production involved in immune response   • production of molecular mediator of immune response   • regulation of cytokine production involved in immune response   • positive regulation of cytokine production involved in immune response   • positive regulation of production of molecular mediator of immune response   • regulation of production of molecular mediator of immune response   • response to cytokine   • cytokine-mediated signaling pathway   • cellular response to tumor necrosis factor   • tumor necrosis factor-mediated signaling pathway   • cellular response to cytokine stimulus   • regulation of tumor necrosis factor-mediated signaling pathway   • regulation of cytokine-mediated signaling pathway   • negative regulation of tumor necrosis factor-mediated signaling pathway   • response to peptide   • regulation of response to cytokine stimulus   • negative regulation of response to cytokine stimulus   • negative regulation of cytokine-mediated signaling pathway   • response to tumor necrosis factor   • regulation of type II interferon production   • type II interferon production   • positive regulation of type II interferon production   • pseudopodium   • early endosome   • endosome   • intracellular vesicle   • cytoplasmic vesicle   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • Ras protein signal transduction   • photoreceptor disc membrane
SCOP2Domain Identifier• G protein-coupled receptor-like
SCOP2Family Identifier• G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9D0A_Chain_A
EKAEKILDR LLLLGGESG KSTGIEFKV NFHMFDVGG RKWIQCFND 
VTAIIFVVS SYNRLQEAL NFKSIWNNR WLRTISVIL FLNKQDLLA 
EKVLAGKSK IEDYFPEFA RYTTPEGED PRVTRAKYF IREFISTAS 
GDGRHCYPH FTCAVDTEN RRFNDCDII MLRYLSADA VRSMDRNRE 
GEKARELKT FITIYPDLQ DDDKVDIAI KLQNENV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9D0A_Chain_B
DPVGRIQMR TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW 
DSYTTNKVH AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK 
TREGNVRVS RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE 
TGQQTTTFT GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM 
CRQTFTGHE SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM 
TYSHDNIIC GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV 
LAGHDNRVS CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9D0A_Chain_G
VSKAAADLM AYCEAHAKE DPLLTPVPA SENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP55085
Sequence
>9D0A_Chain_R
SLIDEFSAS VLTGKLTTV FLPIVYTIV FVVGLPSNG MALWVFLFR 
TKKKHPAVI YMANLALAD LLSVIWFPL KIAYHIHGN NWIYGEALC 
NVLIGFFYG NMYCSILFM TCLSVQRYW VIVNPMGHS RKKANIAIG 
ISLAIWLLI LLVTIPLYV VKQTIFIPA LNITTCHDV LPEQLLVGD 
MFNYFLSLA IGVFLFPAF LTASAYVLM IRMLRSSAM DENSEKKRK 
RAIKLIVTV LAMYLICFT PSNLLLVVH YFLIKSQGQ SHVYALYIV 
ALCLSTLNS CIDPFVYYF VSHDFRDHA KNAL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5NDDAPeptideProteinase ActivatedPAR2Homo sapiens-AZ8838; Na-2.82017-05-03doi.org/10.1038/nature22309
5NDZAPeptideProteinase ActivatedPAR2Homo sapiens-AZ3451; Na-3.62017-05-03doi.org/10.1038/nature22309
5NJ6APeptideProteinase ActivatedPAR2Homo sapiens---42017-05-03doi.org/10.1038/nature22309
9D0AAPeptideProteinase ActivatedPAR2Homo sapiens--chim(NtGi1L-Gs-CtGq)/β1/γ23.12025-05-07doi.org/10.1038/s41467-025-59138-x
9D0A (No Gprot) APeptideProteinase ActivatedPAR2Homo sapiens--3.12025-05-07doi.org/10.1038/s41467-025-59138-x
9E7RAPeptideProteinase ActivatedPAR2Homo sapiensGB88-chim(NtGi1L-Gs-CtGq)/β1/γ23.182025-05-07doi.org/10.1038/s41467-025-59138-x
9E7R (No Gprot) APeptideProteinase ActivatedPAR2Homo sapiensGB88-3.182025-05-07doi.org/10.1038/s41467-025-59138-x
8ZMDAPeptideProteinase ActivatedPAR2Homo sapiens--chim(NtGi1L-Gs-CtGq)/β1/γ23.252025-05-28To be published
8ZMD (No Gprot) APeptideProteinase ActivatedPAR2Homo sapiens--3.252025-05-28To be published
8ZMEAPeptideProteinase ActivatedPAR2Homo sapiens--chim(NtGi1-G13)/β1/γ23.22025-05-28To be published
8ZME (No Gprot) APeptideProteinase ActivatedPAR2Homo sapiens--3.22025-05-28To be published




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