Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:E902 7.55667610
2M:M:E901 7.26286720
3R:R:L26 3.786515
4R:R:F38 5.624518
5R:R:H41 4.72143718
6R:R:V53 3.95413
7R:R:R57 9.906514
8R:R:Q60 4.09333617
9R:R:R61 6.76875814
10R:R:L62 3.666515
11R:R:E63 4.09718
12R:R:M65 3.7225419
13R:R:L66 3.635405
14R:R:F67 5.538517
15R:R:R71 6.8575417
16R:R:I72 4.1925419
17R:R:L78 4.438517
18R:R:L79 3.8275409
19R:R:H87 4.524134
20R:R:I88 3.7617
21R:R:L89 4.2145135
22R:R:D90 6.2675419
23R:R:C92 8.1875418
24R:R:D95 4.116524
25R:R:H97 6.5425413
26R:R:F105 4.5945136
27R:R:G138 1.764217
28R:R:I140 2.8325407
29R:R:G142 2.65515
30R:R:S143 4.202514
31R:R:Y144 5.4254123
32R:R:L155 3.5575416
33R:R:R156 5.9925405
34R:R:L157 3.25405
35R:R:F158 5.1775406
36R:R:I160 2.985406
37R:R:Q162 4.86418
38R:R:Y165 4.94667618
39R:R:A166 3.03415
40R:R:T168 4.3075417
41R:R:L172 6.8175417
42R:R:R177 7.835415
43R:R:Y178 5.5675416
44R:R:Y180 5.775406
45R:R:F181 6.89519
46R:R:R183 6.49333619
47R:R:V185 4.03517
48R:R:P186 3.398518
49R:R:P187 3.798517
50R:R:D188 6.16418
51R:R:F190 3.345415
52R:R:Q191 5.09667618
53R:R:W204 7.162519
54R:R:Y206 5.064539
55R:R:S208 2.405438
56R:R:T209 4.5375406
57R:R:Y216 4.35125817
58R:R:F224 3.122507
59R:R:R231 4.77404
60R:R:A236 3.28438
61R:R:V241 4.794126
62R:R:M245 6.94123
63R:R:F250 7.65754123
64R:R:V265 4.358518
65R:R:L268 3.776565
66R:R:F269 4.38429717
67R:R:E273 5.494121
68R:R:D274 5.494124
69R:R:F289 4.72406
70R:R:W291 5.02143767
71R:R:S294 4.3825418
72R:R:D295 4.01286718
73R:R:W297 5.13222966
74R:R:V303 4.425464
75R:R:V304 4.58564
76R:R:E318 4.202506
77R:R:L319 3.75667614
78R:R:F327 3.4531018
79R:R:Y330 5.078518
80R:R:F331 4.88833616
81R:R:L334 3.282515
82R:R:P336 7.63616
83R:R:W337 3.5175413
84R:R:N339 6.106514
85R:R:R341 4.7075404
86R:R:N342 4.58286717
87R:R:P343 6.145412
88R:R:W344 4.28714
89R:R:F345 5.98667614
90R:R:F348 5.4625416
91R:R:W349 7.83286718
92R:R:R352 6.5875413
93R:R:F353 10.324517
94R:R:F357 7.27613
95R:R:F372 5.76615
96R:R:Q374 6.27415
97R:R:E375 5.49667615
98R:R:K377 4.39143713
99R:R:I378 5.22517
100R:R:M379 6.38408
101R:R:F380 4.79516
102R:R:Y386 6.32333616
103R:R:M388 4.02754216
104R:R:M395 5.772585
105R:R:M410 3.75582
106R:R:R417 5.788586
107R:R:L418 3.278587
108R:R:Y419 4.59405
109R:R:F422 4.564584
110R:R:F428 8.6375408
111R:R:P431 6.152517
112R:R:F432 3.44286714
113R:R:R433 3.118336173
114R:R:F443 2.7475408
115R:R:D448 6.71333617
116R:R:Y453 3.68667618
117R:R:F456 3.2525465
118R:R:Y458 9.08465
119R:R:Y466 12.1675462
120R:R:Y468 5.15833664
121R:R:W474 4.27571716
122R:R:L478 3.625416
123R:R:L480 4.03416
124R:R:I485 4.7775417
125R:R:W487 3.92222917
126R:R:C500 6.1775439
127R:R:C504 4.85439
128R:R:E508 4.83536
129R:R:K510 13.925437
130R:R:Q513 4.504535
131R:R:P514 2.6475435
132R:R:E516 6.3575434
133R:R:C519 6.0575439
134R:R:W520 8.59537
135R:R:Y528 5.51667638
136R:R:E529 4.866538
137R:R:Y530 3.498336187
138R:R:C537 4.1325439
139R:R:C540 5.06754189
140R:R:W545 5.73406
141R:R:P546 4.88254188
142R:R:L556 3.1325448
143R:R:P571 2.364258
144R:R:F589 2.754279
145R:R:T595 5.5254199
146R:R:R603 3.088509
147R:R:G612 2.365408
148R:R:F614 4.02405
149R:R:Y617 4.56508
150R:R:T620 4.154257
151R:R:F623 4.35548
152R:R:P627 3.465649
153R:R:R635 6.385448
154R:R:L639 4.19448
155R:R:F643 6.628548
156R:R:Y647 4.58546
157R:R:F661 4.0154299
158R:R:R670 4.2554305
159R:R:C683 2.9965287
160R:R:Q690 5.79667649
161R:R:E701 8.534316
162R:R:P703 2.5325409
163R:R:R713 5.9575433
164R:R:V717 4.63548
165R:R:L719 3.295447
166R:R:Y734 3.95167648
167R:R:N735 4.4075447
168R:R:C752 3.17754298
169R:R:I762 2.4475409
170R:R:M766 3.2125449
171R:R:Y767 5.382509
172R:R:W773 5.444549
173R:R:F776 6.12449
174R:R:P778 2.985408
175R:R:R788 6.294505
176R:R:V789 4.365405
177R:R:F810 4.4045279
178R:R:I817 3.4325409
179R:R:N824 6.3954199
180S:S:L26 3.05833625
181S:S:L32 2.848595
182S:S:F38 5.212528
183S:S:H41 4.32728
184S:S:C50 5.24429
185S:S:R57 9.46524
186S:S:Q60 3.688527
187S:S:R61 6.47125824
188S:S:L62 3.53425
189S:S:E63 4.12728
190S:S:M65 3.7525409
191S:S:F67 6.6075427
192S:S:R71 7.19427
193S:S:L78 4.65167627
194S:S:L79 3.8409
195S:S:I88 2.644527
196S:S:L89 4.27425
197S:S:D90 6.5225429
198S:S:C92 6.3225428
199S:S:F105 4.426526
200S:S:T137 2.7225494
201S:S:G138 1.76497
202S:S:G142 2.385425
203S:S:S143 4.7775424
204S:S:L155 3.5575426
205S:S:F158 5.505406
206S:S:I160 2.985406
207S:S:Q162 4.15667628
208S:S:Y165 5.105628
209S:S:A166 3.405425
210S:S:T168 4.3075427
211S:S:L172 7.12427
212S:S:R177 6.572525
213S:S:Y178 5.535426
214S:S:Y180 5.5275406
215S:S:F181 6.888529
216S:S:R183 5.67833629
217S:S:V185 4.1825407
218S:S:P186 3.046528
219S:S:P187 4.41527
220S:S:D188 6.7425428
221S:S:Q191 5.13167628
222S:S:F201 4.85435
223S:S:F202 8.8025438
224S:S:W204 6.64539
225S:S:Y206 6.32439
226S:S:S208 2.405438
227S:S:E213 4.334226
228S:S:Y216 5.45625827
229S:S:F224 3.28407
230S:S:E227 5.54405
231S:S:R231 4.156504
232S:S:A236 4.415438
233S:S:M245 5.41254353
234S:S:V254 2.4025405
235S:S:A263 2.6375437
236S:S:V265 4.36538
237S:S:L268 4.0875455
238S:S:F269 6.88286727
239S:S:E273 5.4854341
240S:S:W291 4.18625857
241S:S:S294 4.176528
242S:S:D295 4.15429728
243S:S:W297 4.781056
244S:S:V303 4.1175454
245S:S:V304 4.58554
246S:S:E308 5.715454
247S:S:I317 3.4025426
248S:S:E318 4.9275406
249S:S:L319 4.825424
250S:S:Y322 7.095203
251S:S:F327 3.57667928
252S:S:Y330 6.3625428
253S:S:F331 4.31333626
254S:S:L334 5.1525425
255S:S:D335 4.555424
256S:S:P336 7.67167626
257S:S:N339 7.4275424
258S:S:N342 4.77857727
259S:S:P343 5.7275422
260S:S:W344 4.32375824
261S:S:F345 5.91333624
262S:S:F348 5.97426
263S:S:W349 7.44286728
264S:S:R352 5.3475423
265S:S:F353 11.905427
266S:S:F357 11.05523
267S:S:F372 4.785625
268S:S:Q374 4.9975425
269S:S:E375 4.80857725
270S:S:K377 5.32857723
271S:S:I378 4.668527
272S:S:M379 7.0275408
273S:S:F380 6.054506
274S:S:Y386 5.165626
275S:S:M388 3.695496
276S:S:H393 4.34407
277S:S:M395 7.0725495
278S:S:C400 4.5554373
279S:S:M410 4.9575402
280S:S:R417 4.854596
281S:S:Y419 4.61405
282S:S:F422 5.066594
283S:S:P431 5.1375427
284S:S:F432 4.258524
285S:S:R433 5.0425203
286S:S:T437 6.094204
287S:S:F443 3.4725408
288S:S:D448 6.14167627
289S:S:Y453 4.272528
290S:S:N454 5.565457
291S:S:F456 3.2525455
292S:S:Y458 7.13167655
293S:S:Y466 11.4275452
294S:S:Y468 6.41333654
295S:S:V471 2.7407
296S:S:W474 5.036506
297S:S:L478 3.2325436
298S:S:I485 5.1825437
299S:S:W487 4.25125837
300S:S:C500 6.0675439
301S:S:S501 4.0175438
302S:S:C504 4.445439
303S:S:E508 6.298536
304S:S:K510 9.2875437
305S:S:Q513 6.26535
306S:S:E516 3.8225434
307S:S:C519 3.756539
308S:S:W520 8.67437
309S:S:Y528 8.16167678
310S:S:E529 6.34478
311S:S:Y530 3.3175407
312S:S:F535 5.135432
313S:S:D539 5.1325473
314S:S:W545 14.876576
315S:S:L556 3.074578
316S:S:W567 5.54335
317S:S:P571 2.83254168
318S:S:L586 3.14254145
319S:S:V597 2.655157
320S:S:F614 4.065405
321S:S:Y617 4.3765408
322S:S:M619 2.9325407
323S:S:T620 2.94754167
324S:S:L639 2.974508
325S:S:F643 6.4756108
326S:S:Y647 5.6165106
327S:S:Q690 5.967147109
328S:S:V694 2.235406
329S:S:P703 3.825119
330S:S:R714 17.8375474
331S:S:L719 8.66754117
332S:S:Y734 5.587108
333S:S:N735 4.8754107
334S:S:N755 4.91754157
335S:S:M766 3.932867429
336S:S:Y767 3.155409
337S:S:W773 4.833336109
338S:S:V789 2.7854335
339S:S:T792 1.835407
340S:S:F810 5.5045149
341W:W:?901 7.720671540
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1S:S:F380 S:S:K377 11.34134.96YesYes063
2S:S:K377 S:S:R61 13.4797.43YesYes234
3S:S:R57 S:S:R61 13.290612.79YesYes244
4R:R:F38 R:R:R61 11.27152.14YesYes184
5R:R:E375 R:R:R57 21.08385.82YesYes154
6R:R:E375 R:R:Q60 14.35482.55YesYes157
7R:R:L300 R:R:R57 50.577610.93NoYes054
8R:R:F380 R:R:M379 12.2417.46YesYes068
9R:R:E318 R:R:K377 10.72362.7YesYes063
10R:R:E318 R:R:L319 27.15352.65YesYes064
11R:R:L300 R:R:V303 50.8062.98NoYes054
12R:R:V303 R:R:W297 50.91899.81YesYes646
13R:R:L268 R:R:W297 47.57232.28YesYes656
14R:R:L268 R:R:V210 50.32294.47YesNo055
15R:R:L257 R:R:V210 50.40252.98NoNo075
16R:R:L257 R:R:S208 99.21793NoYes078
17R:R:A236 R:R:S208 49.86241.71YesYes388
18R:R:A236 R:R:Y206 49.99558.01YesYes389
19R:R:W291 R:R:W297 47.70784.69YesYes676
20R:R:F289 R:R:W291 48.489610.02YesYes067
21R:R:F289 R:R:L257 48.72862.44YesNo067
22R:R:A263 R:R:S208 49.82881.71NoYes378
23R:R:A263 R:R:Y206 49.87312.67NoYes379
24R:R:C500 R:R:Y206 1009.41YesYes399
25R:R:E318 R:R:F456 38.06182.33YesYes065
26R:R:F456 R:R:Y468 38.51762.06YesYes654
27R:R:L418 R:R:M395 10.40055.65YesYes875
28R:R:C500 R:R:S501 26.91373.44YesNo398
29R:R:C500 R:R:C519 28.13337.28YesYes399
30R:R:C500 S:S:Q513 72.59964.58YesYes395
31R:R:S501 R:R:W520 72.22448.65NoYes387
32R:R:K510 R:R:W520 69.498127.85YesYes377
33R:R:E534 R:R:K510 69.191718.9NoYes367
34R:R:E534 R:R:R531 69.02844.65NoNo367
35R:R:C537 R:R:R531 68.51852.79YesNo397
36R:R:C537 R:R:E529 68.18373.04YesYes398
37R:R:E529 R:R:Y528 66.31076.73YesYes388
38R:R:W545 R:R:Y528 64.80972.89YesYes068
39R:R:Q513 S:S:Q513 58.34355.12YesYes355
40R:R:P514 R:R:Q513 44.09943.16YesYes355
41R:R:C519 R:R:E516 59.84567.6YesYes394
42R:R:E516 S:S:Q513 28.12217.65YesYes345
43R:R:E516 S:S:E516 74.11643.81YesYes344
44R:R:Q513 S:S:E516 28.11122.55YesYes354
45R:R:P514 S:S:C500 43.26263.77YesYes359
46S:S:C519 S:S:E516 14.58766.08YesYes394
47R:R:L556 R:R:W545 61.28334.56YesYes086
48R:R:L556 R:R:V717 60.77532.98YesYes488
49R:R:Q558 R:R:V717 60.27072.87NoYes448
50R:R:L719 R:R:Q558 60.10592.66YesNo474
51R:R:K626 R:R:L719 19.40782.82NoYes447
52R:R:K626 R:R:Y560 19.498519.11NoNo046
53R:R:R562 R:R:Y560 19.325524.69NoNo066
54R:R:D565 R:R:R562 19.15243.57NoNo066
55R:R:D565 R:R:R788 18.97942.38NoYes065
56R:R:R788 R:R:W567 10.27657YesNo055
57R:R:L719 R:R:P627 40.35913.28YesYes479
58R:R:P627 R:R:R635 37.71978.65YesYes498
59R:R:F623 R:R:R635 37.06997.48YesYes488
60R:R:F623 W:W:?901 34.6576.85YesYes480
61R:R:I739 W:W:?901 17.00283.44NoYes480
62R:R:I739 R:R:M766 16.65615.83NoYes489
63R:R:C742 R:R:M766 16.33231.62NoYes099
64R:R:C742 R:R:L650 15.46643.17NoNo098
65R:R:L609 R:R:L650 15.29342.77NoNo088
66R:R:F810 R:R:L609 14.81143.65YesNo098
67S:S:E516 S:S:V512 88.09672.85YesNo042
68S:S:F535 S:S:V512 87.97982.62YesNo022
69S:S:D533 S:S:F535 42.71082.39NoYes372
70S:S:D533 S:S:L532 42.39386.79NoNo376
71S:S:A538 S:S:L532 42.24254.73NoNo016
72S:S:A538 S:S:Y530 42.08665.34NoYes017
73S:S:C553 S:S:Y530 97.17712.69NoYes097
74S:S:C553 S:S:Y544 94.19742.69NoNo094
75S:S:E555 S:S:Y544 93.8943.37NoNo034
76S:S:E555 S:S:K707 93.68042.7NoNo032
77S:S:K707 S:S:Q558 93.466818.98NoNo024
78S:S:L719 S:S:Q558 93.253222.63YesNo074
79S:S:L719 S:S:P627 91.96264.93YesNo1179
80S:S:C721 S:S:P627 91.75711.88NoNo1199
81S:S:C721 S:S:H723 90.23562.95NoNo1195
82S:S:H723 S:S:R636 90.046213.54NoNo058
83S:S:R636 S:S:W697 89.404332.99NoNo087
84S:S:M728 S:S:W697 88.54812.33NoNo077
85S:S:L639 S:S:M728 78.96242.83YesNo087
86S:S:F643 S:S:L639 76.38896.09YesYes088
87S:S:F643 S:S:Y647 37.77717.22YesYes1086
88S:S:I739 S:S:Y647 37.19619.67NoYes1086
89S:S:C770 S:S:I739 73.88941.64NoNo078
90S:S:C770 S:S:T743 73.45395.07NoNo078
91S:S:E534 S:S:F535 45.17039.33NoYes362
92S:S:E534 S:S:R531 62.26192.33NoNo067
93S:S:L550 S:S:R531 58.23784.86NoNo067
94S:S:L550 S:S:Y530 58.11632.34NoYes067
95S:S:F643 S:S:W773 37.777913.03YesYes1089
96S:S:I739 S:S:W773 37.12893.52NoYes1089
97S:S:M766 S:S:T743 68.22397.53YesNo098
98S:S:M766 S:S:T765 15.3523.01YesNo099
99S:S:T765 S:S:V805 14.47543.17NoNo097
100S:S:V804 S:S:V805 14.03711.6NoNo077
101R:R:T783 R:R:V789 14.29026.35NoYes075
102R:R:T783 R:R:V782 13.94213.17NoNo078
103R:R:V782 S:S:V782 13.24571.6NoNo088
104R:R:I779 S:S:V782 12.89753.07NoNo078
105R:R:I779 S:S:I779 12.54932.94NoNo077
106R:R:P778 S:S:I779 12.20113.39YesNo087
107R:R:P778 S:S:V789 11.15621.77YesYes085
108S:S:V789 S:S:W567 10.11093.68YesYes3355
109S:S:F38 S:S:R61 24.17512.14YesYes284
110S:S:F38 S:S:M65 12.38896.22YesYes089
111S:S:L300 S:S:R57 23.529110.93NoYes054
112S:S:C500 S:S:Y206 75.33088.06YesYes399
113S:S:A263 S:S:Y206 40.26735.34YesYes379
114S:S:A236 S:S:Y206 35.03869.34YesYes389
115S:S:A236 S:S:S208 34.95741.71YesYes388
116S:S:A263 S:S:S208 34.97161.71YesYes378
117S:S:L257 S:S:S208 69.79793NoYes078
118S:S:E318 S:S:K377 33.89544.05YesYes063
119S:S:E318 S:S:G298 41.19693.27YesNo066
120S:S:G298 S:S:W297 41.27612.81NoYes066
121S:S:L268 S:S:W297 34.38282.28YesYes556
122S:S:L268 S:S:V210 34.43244.47YesNo055
123S:S:L257 S:S:V210 34.59592.98NoNo075
124S:S:W291 S:S:W297 34.56113.75YesYes576
125S:S:F289 S:S:W291 35.07747.02NoYes067
126S:S:F289 S:S:L257 35.15213.65NoNo067
127S:S:L300 S:S:V303 23.6712.98NoYes054
128S:S:V303 S:S:W297 23.72728.58YesYes546
129S:S:S501 S:S:W520 18.59597.41YesYes387
130S:S:K510 S:S:W520 17.403122.05YesYes377
131S:S:L650 S:S:M766 36.36684.24NoYes089
132S:S:L609 S:S:L650 35.92952.77NoNo088
133S:S:F810 S:S:L609 35.05473.65YesNo098
134S:S:C606 S:S:F810 30.24222.79NoYes099
135S:S:C606 S:S:F589 21.04024.19NoNo099
136S:S:F589 S:S:K813 20.60224.96NoNo099
137S:S:K813 S:S:S601 10.08213.06NoNo1599
138S:S:N755 S:S:V597 16.65881.48YesYes1577
139S:S:E758 S:S:K813 10.08212.7NoNo1599
140S:S:C742 S:S:M766 10.08854.86NoYes099
141S:S:N655 S:S:Y745 11.84352.33NoNo067
142R:R:R57 R:R:R61 23.500813.86YesYes144
143R:R:W297 R:R:Y468 40.42854.82YesYes664
144R:R:E516 R:R:Q513 13.8646.37YesYes345
145R:R:C519 R:R:S501 45.47771.72YesNo398
146S:S:C500 S:S:C519 14.1977.28YesYes399
147R:R:C519 S:S:Q513 13.83877.63YesYes395
148S:S:C500 S:S:S501 17.88625.16YesYes398
149S:S:E534 S:S:K510 17.21274.05NoYes367
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
M:M:E901 S:S:R57 17.45 2 Yes Yes 0 4 0 1
M:M:E901 S:S:R61 9.3 2 Yes Yes 0 4 0 1
M:M:E901 S:S:S145 2.87 2 Yes No 0 8 0 1
M:M:E901 S:S:A166 6.03 2 Yes Yes 0 5 0 1
M:M:E901 S:S:Y216 4.49 2 Yes Yes 0 7 0 1
M:M:E901 S:S:D295 2.6 2 Yes Yes 0 8 0 1
M:M:E901 S:S:K377 8.1 2 Yes Yes 0 3 0 1
S:S:F38 S:S:R61 2.14 2 Yes Yes 8 4 2 1
S:S:F38 S:S:Y165 10.32 2 Yes Yes 8 8 2 2
S:S:R57 S:S:R61 12.79 2 Yes Yes 4 4 1 1
S:S:R57 S:S:S272 2.64 2 Yes No 4 2 1 2
S:S:L300 S:S:R57 10.93 0 No Yes 5 4 2 1
S:S:E375 S:S:R57 3.49 2 Yes Yes 5 4 2 1
S:S:R61 S:S:S143 2.64 2 Yes Yes 4 4 1 2
S:S:R61 S:S:Y165 2.06 2 Yes Yes 4 8 1 2
S:S:E375 S:S:R61 12.79 2 Yes Yes 5 4 2 1
S:S:K377 S:S:R61 7.43 2 Yes Yes 3 4 1 1
S:S:R61 S:S:V381 2.62 2 Yes No 4 7 1 2
S:S:S143 S:S:Y165 7.63 2 Yes Yes 4 8 2 2
S:S:A166 S:S:S143 1.71 2 Yes Yes 5 4 1 2
S:S:S145 S:S:S169 3.26 2 No No 8 7 1 2
S:S:S145 S:S:Y216 3.82 2 No Yes 8 7 1 1
S:S:A166 S:S:Y165 2.67 2 Yes Yes 5 8 1 2
S:S:V381 S:S:Y165 5.05 2 No Yes 7 8 2 2
S:S:A166 S:S:K377 3.21 2 Yes Yes 5 3 1 1
S:S:D188 S:S:T168 8.67 2 Yes Yes 8 7 2 2
S:S:T168 S:S:Y216 2.5 2 Yes Yes 7 7 2 1
S:S:D295 S:S:T168 2.89 2 Yes Yes 8 7 1 2
S:S:D188 S:S:Q191 6.53 2 Yes Yes 8 8 2 2
S:S:D188 S:S:Y216 4.6 2 Yes Yes 8 7 2 1
S:S:D188 S:S:F269 7.17 2 Yes Yes 8 7 2 2
S:S:F269 S:S:Q191 2.34 2 Yes Yes 7 8 2 2
S:S:Q191 S:S:S294 4.33 2 Yes Yes 8 8 2 2
S:S:D295 S:S:Q191 7.83 2 Yes Yes 8 8 1 2
S:S:G217 S:S:Y216 4.35 0 No Yes 8 7 2 1
S:S:F269 S:S:Y216 15.47 2 Yes Yes 7 7 2 1
S:S:S294 S:S:Y216 3.82 2 Yes Yes 8 7 2 1
S:S:D295 S:S:Y216 4.6 2 Yes Yes 8 7 1 1
S:S:F269 S:S:S294 7.93 2 Yes Yes 7 8 2 2
S:S:D295 S:S:S294 2.94 2 Yes Yes 8 8 1 2
S:S:D295 S:S:L319 4.07 2 Yes Yes 8 4 1 2
S:S:D295 S:S:K377 4.15 2 Yes Yes 8 3 1 1
S:S:E318 S:S:K377 4.05 0 Yes Yes 6 3 2 1
S:S:F380 S:S:L319 6.09 0 Yes Yes 6 4 2 2
S:S:E375 S:S:K377 5.4 2 Yes Yes 5 3 2 1
S:S:F380 S:S:K377 4.96 0 Yes Yes 6 3 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:E902 R:R:R57 16.28 1 Yes Yes 0 4 0 1
L:L:E902 R:R:R61 9.3 1 Yes Yes 0 4 0 1
L:L:E902 R:R:S145 2.87 1 Yes No 0 8 0 1
L:L:E902 R:R:A166 4.53 1 Yes Yes 0 5 0 1
L:L:E902 R:R:Y216 5.61 1 Yes Yes 0 7 0 1
L:L:E902 R:R:K377 6.75 1 Yes Yes 0 3 0 1
R:R:F38 R:R:R61 2.14 1 Yes Yes 8 4 2 1
R:R:F38 R:R:Y165 12.38 1 Yes Yes 8 8 2 2
R:R:R57 R:R:R61 13.86 1 Yes Yes 4 4 1 1
R:R:R57 R:R:S272 2.64 1 Yes No 4 2 1 2
R:R:L300 R:R:R57 10.93 0 No Yes 5 4 2 1
R:R:E375 R:R:R57 5.82 1 Yes Yes 5 4 2 1
R:R:R61 R:R:S143 3.95 1 Yes Yes 4 4 1 2
R:R:R61 R:R:Y165 2.06 1 Yes Yes 4 8 1 2
R:R:E375 R:R:R61 12.79 1 Yes Yes 5 4 2 1
R:R:K377 R:R:R61 7.43 1 Yes Yes 3 4 1 1
R:R:R61 R:R:V381 2.62 1 Yes No 4 7 1 2
R:R:S143 R:R:Y165 6.36 1 Yes Yes 4 8 2 2
R:R:A166 R:R:S143 1.71 1 Yes Yes 5 4 1 2
R:R:S145 R:R:S169 4.89 1 No No 8 7 1 2
R:R:S145 R:R:Y216 3.82 1 No Yes 8 7 1 1
R:R:A166 R:R:Y165 2.67 1 Yes Yes 5 8 1 2
R:R:V381 R:R:Y165 3.79 1 No Yes 7 8 2 2
R:R:A166 R:R:K377 3.21 1 Yes Yes 5 3 1 1
R:R:D188 R:R:T168 8.67 1 Yes Yes 8 7 2 2
R:R:T168 R:R:Y216 2.5 1 Yes Yes 7 7 2 1
R:R:D295 R:R:T168 2.89 1 Yes Yes 8 7 2 2
R:R:D188 R:R:Y216 5.75 1 Yes Yes 8 7 2 1
R:R:D188 R:R:F269 2.39 1 Yes Yes 8 7 2 2
R:R:G217 R:R:Y216 4.35 0 No Yes 8 7 2 1
R:R:F269 R:R:Y216 3.09 1 Yes Yes 7 7 2 1
R:R:S294 R:R:Y216 5.09 1 Yes Yes 8 7 2 1
R:R:D295 R:R:Y216 4.6 1 Yes Yes 8 7 2 1
R:R:F269 R:R:S294 6.61 1 Yes Yes 7 8 2 2
R:R:D295 R:R:S294 2.94 1 Yes Yes 8 8 2 2
R:R:D295 R:R:K377 2.77 1 Yes Yes 8 3 2 1
R:R:E318 R:R:K377 2.7 0 Yes Yes 6 3 2 1
R:R:E375 R:R:K377 5.4 1 Yes Yes 5 3 2 1
R:R:F380 R:R:K377 2.48 1 Yes Yes 6 3 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F623 R:R:M619 2.49 4 Yes No 8 7 1 2
R:R:F623 R:R:R635 7.48 4 Yes Yes 8 8 1 2
R:R:F623 R:R:L639 2.44 4 Yes Yes 8 8 1 1
R:R:F623 R:R:M794 2.49 4 Yes No 8 9 1 1
R:R:F623 W:W:?901 6.85 4 Yes Yes 8 0 1 0
R:R:G640 R:R:L639 1.71 4 No Yes 6 8 1 1
R:R:L639 W:W:?901 11.12 4 Yes Yes 8 0 1 0
R:R:G640 R:R:S731 1.86 4 No No 6 7 1 1
R:R:G640 W:W:?901 5.49 4 No Yes 6 0 1 0
R:R:F643 R:R:Y647 7.22 4 Yes Yes 8 6 1 2
R:R:F643 R:R:N735 3.62 4 Yes Yes 8 7 1 1
R:R:F643 R:R:W773 2 4 Yes Yes 8 9 1 1
R:R:F643 R:R:S801 6.61 4 Yes No 8 9 1 2
R:R:F643 W:W:?901 13.69 4 Yes Yes 8 0 1 0
R:R:N735 R:R:Y647 2.33 4 Yes Yes 7 6 1 2
R:R:I739 R:R:Y647 8.46 4 No Yes 8 6 1 2
R:R:M766 R:R:Y647 2.39 4 Yes Yes 9 6 2 2
R:R:T769 R:R:Y647 2.5 0 No Yes 8 6 2 2
R:R:Q690 R:R:S731 10.11 4 Yes No 9 7 2 1
R:R:N735 R:R:Q690 3.96 4 Yes Yes 7 9 1 2
R:R:R720 R:R:R724 6.4 0 No No 6 8 2 1
R:R:R724 W:W:?901 9.76 0 No Yes 8 0 1 0
R:R:M728 W:W:?901 12.49 0 No Yes 7 0 1 0
R:R:S731 W:W:?901 4.82 4 No Yes 7 0 1 0
R:R:L732 W:W:?901 6.67 0 No Yes 8 0 1 0
R:R:N735 W:W:?901 7.72 4 Yes Yes 7 0 1 0
R:R:I739 R:R:M766 5.83 4 No Yes 8 9 1 2
R:R:I739 W:W:?901 3.44 4 No Yes 8 0 1 0
R:R:T769 R:R:W773 2.43 0 No Yes 8 9 2 1
R:R:S801 R:R:T769 3.2 0 No No 9 8 2 2
R:R:F776 R:R:W773 9.02 4 Yes Yes 9 9 1 1
R:R:S797 R:R:W773 3.71 4 No Yes 9 9 2 1
R:R:W773 W:W:?901 10.06 4 Yes Yes 9 0 1 0
R:R:F776 R:R:F780 8.57 4 Yes No 9 8 1 1
R:R:F776 R:R:S797 3.96 4 Yes No 9 9 1 2
R:R:F776 W:W:?901 2.93 4 Yes Yes 9 0 1 0
R:R:F780 R:R:Q790 15.23 4 No No 8 7 1 2
R:R:F780 W:W:?901 5.87 4 No Yes 8 0 1 0
R:R:M794 W:W:?901 13.63 4 No Yes 9 0 1 0
R:R:L639 R:R:V798 1.49 4 Yes No 8 8 1 2
R:R:L732 R:R:V736 1.49 0 No No 8 5 1 2
R:R:C770 W:W:?901 1.27 0 No Yes 7 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7MTS_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 1.71
Number of Linked Nodes 1461
Number of Links 1913
Number of Hubs 341
Number of Links mediated by Hubs 1223
Number of Communities 43
Number of Nodes involved in Communities 532
Number of Links involved in Communities 835
Path Summary
Number Of Nodes in MetaPath 150
Number Of Links MetaPath 149
Number of Shortest Paths 19386644
Length Of Smallest Path 3
Average Path Length 55.7616
Length of Longest Path 81
Minimum Path Strength 1.145
Average Path Strength 7.21458
Maximum Path Strength 26
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.7027
Average % Of Corr. Nodes 64.1596
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 64.1063
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development
Gene OntologyBiological Process• multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • glutamate receptor activity   • scaffold protein binding   • protein binding   • binding   • calcium channel activity   • monoatomic cation transmembrane transporter activity   • channel regulator activity   • monoatomic ion channel activity   • ion channel regulator activity   • calcium channel regulator activity   • monoatomic cation channel activity   • passive transmembrane transporter activity   • calcium ion transmembrane transporter activity   • inorganic molecular entity transmembrane transporter activity   • channel activity   • inorganic cation transmembrane transporter activity   • molecular function regulator activity   • monoatomic ion transmembrane transporter activity   • transporter activity   • metal ion transmembrane transporter activity   • transporter regulator activity   • transmembrane transporter activity   • group II metabotropic glutamate receptor activity   • G protein-coupled glutamate receptor activity   • adenylate cyclase inhibiting G protein-coupled glutamate receptor activity   • regulation of localization   • nitrogen compound transport   • regulation of cellular process   • transport   • regulation of glutamate secretion   • localization   • secretion by cell   • regulation of secretion by cell   • regulation of amino acid transport   • glutamate secretion   • regulation of biological process   • organic anion transport   • carboxylic acid transport   • secretion   • regulation of transport   • biological regulation   • export from cell   • establishment of localization   • regulation of secretion   • organic acid transport   • amino acid transport   • amine transport   • acidic amino acid transport   • regulation of organic acid transport   • dicarboxylic acid transport   • cellular process   • regulation of amine transport   • trans-synaptic signaling   • regulation of signaling   • modulation of chemical synaptic transmission   • signaling   • cell-cell signaling   • presynaptic modulation of chemical synaptic transmission   • chemical synaptic transmission   • cell communication   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • regulation of cell communication   • monoamine transport   • regulation of catecholamine secretion   • organic hydroxy compound transport   • dopamine transport   • catecholamine transport   • signal release   • dopamine secretion   • catecholamine secretion   • regulation of dopamine secretion   • response to stimulus   • regulation of response to stimulus   • response to chemical   • regulation of response to drug   • response to xenobiotic stimulus   • cellular response to stimulus   • positive regulation of cell communication   • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of signal transduction   • positive regulation of biological process   • regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • signal transduction   • positive regulation of cellular process   • positive regulation of intracellular signal transduction   • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of signaling   • regulation of molecular function   • negative regulation of lyase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • cellular response to stress   • response to stress   • intracellular amino acid homeostasis   • cellular homeostasis   • intracellular glutamate homeostasis   • chemical homeostasis   • homeostatic process   • intracellular chemical homeostasis   • biosynthetic process   • metabolic process   • macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • cell surface receptor signaling pathway   • glutamate receptor signaling pathway   • G protein-coupled glutamate receptor signaling pathway   • G protein-coupled receptor signaling pathway   • negative regulation of signaling   • negative regulation of biological process   • negative regulation of synaptic transmission   • negative regulation of cell communication   • negative regulation of cellular process   • regulation of biological quality   • regulation of synaptic plasticity   • long-term synaptic depression   • behavior   • adult behavior   • multicellular organismal process   • response to nicotine   • behavioral response to nicotine   • synaptic transmission, glutamatergic   • regulation of synaptic transmission, glutamatergic   • response to oxygen-containing compound   • response to nitrogen compound   • response to cocaine   • response to alkaloid   • postsynapse   • postsynaptic membrane   • plasma membrane region   • synaptic membrane   • glial cell projection   • astrocyte projection   • presynapse   • presynaptic membrane   • somatodendritic compartment   • dendrite   • dendritic tree   • glutamatergic synapse   • axon   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to hormone   • response to endogenous stimulus   • response to peptide hormone   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • Golgi apparatus   • endomembrane system   • ciliary basal body   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to hormone stimulus
SCOP2Domain Identifier• Type 1 solute binding protein-like   • Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Type 1 solute binding protein-like   • Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeZQY
PDB ResiduesW:W:?901
Environment DetailsOpen EMBL-EBI Page
CodeZQY
Name2-methoxy-6-propyl-N-(2-{4-[(1H-tetrazol-5-yl)methoxy]phenyl}ethyl)thieno[2,3-d]pyrimidin-4-amine
Synonyms
Identifier
FormulaC20 H23 N7 O2 S
Molecular Weight425.507
SMILES
PubChem11669059
Formal Charge0
Total Atoms53
Total Chiral Atoms0
Total Bonds56
Total Aromatic Bonds21

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ14416
Sequence
>7MTS_nogp_Chain_R
KKVLTLEGD LVLGGLFPV HQKGGPAED CGPVNEHRG IQRLEAMLF 
ALDRINRDP HLLPGVRLG AHILDSCSK DTHALEQAL DFVRASTAI 
TGVIGGSYS DVSIQVANL LRLFQIPQI SYASTSAKL SDKSRYDYF 
ARTVPPDFF QAKAMAEIL RFFNWTYVS TVASEGDYG ETGIEAFEL 
EARARNICV ATSEKVGRA MSRAAFEGV VRALLQKPS ARVAVLFTR 
SEDARELLA ASQRLNASF TWVASDGWG ALESVVAGS EGAAEGAIT 
IELASYPIS DFASYFQSL DPWNNSRNP WFREFWEQR FRCSFRQRD 
CAAHSLRAV PFEQESKIM FVVNAVYAM AHALHNMHR ALCPNTTRL 
CDAMRPVNG RRLYKDFVL NVKFDAPFR PADTHNEVR FDRFGDGIG 
RYNIFTYLR AGGRYRYQK VGYWAEGLT LDTSLIPWA SPSAGPLPA 
SRCSEPCLQ NEVKSVQPG EVCCWLCIP CQPYEYRLD EFTCADCGL 
GYWPNASLT GCFELPQEY IRWGDAWAV GPVTIACLG ALATLFVLG 
VFVRHNATP VVKASGREL CYILLGGVF LCYCMTFIF IAKPSTAVC 
TLRRLGLGT AFSVCYSAL LTKTNRIAR IFGGAREGA QRPRFISPA 
SQVAICLAL ISGQLLIVV AWLVVEAPG TGKETAPER REVVTLRCN 
HRDASMLGS LAYNVLLIA LCTLYAFKT RKCPENFNE AKFIGFTMY 
TTCIIWLAF LPIFYVTSS DYRVQTTTM CVSVSLSGS VVLGCLFAP 
KLHIILFQP QKNVVSHRA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ14416
Sequence
>7MTS_nogp_Chain_S
KKVLTLEGD LVLGGLFPV HQKGGPAED CGPVNEHRG IQRLEAMLF 
ALDRINRDP HLLPGVRLG AHILDSCSK DTHALEQAL DFVRASTAI 
TGVIGGSYS DVSIQVANL LRLFQIPQI SYASTSAKL SDKSRYDYF 
ARTVPPDFF QAKAMAEIL RFFNWTYVS TVASEGDYG ETGIEAFEL 
EARARNICV ATSEKVGRA MSRAAFEGV VRALLQKPS ARVAVLFTR 
SEDARELLA ASQRLNASF TWVASDGWG ALESVVAGS EGAAEGAIT 
IELASYPIS DFASYFQSL DPWNNSRNP WFREFWEQR FRCSFRRDC 
AAHSLRAVP FEQESKIMF VVNAVYAMA HALHNMHRA LCPNTTRLC 
DAMRPVNGR RLYKDFVLN VKFDAPFRP ADTHNEVRF DRFGDGIGR 
YNIFTYLRA GRYRYQKVG YWAEGLTLD TSLIPWASP SAGPLPASR 
CSEPCLQNE VKSVQPGEV CCWLCIPCQ PYEYRLDEF TCADCGLGY 
WPNASLTGC FELPQEYIR WGDAWAVGP VTIACLGAL ATLFVLGVF 
VRHNATPVV KASGRELCY ILLGGVFLC YCMTFIFIA KPSTAVCTL 
RRLGLGTAF SVCYSALLT KTNRIARIF FISPASQVA ICLALISGQ 
LLIVVAWLV VEAPGTGKE TAPERREVV TLRCNHRDA SMLGSLAYN 
VLLIALCTL YAFKTRKCP ENFNEAKFI GFTMYTTCI IWLAFLPIF 
YVTSSDYRV QTTTMCVSV SLSGSVVLG CLFAPKLHI ILFQPQK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WGDCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensWAG/WA6--4.452024-11-27To be published
8WGCCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensLY379268--5.952024-11-27To be published
8WG9CAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiens(2S)-2-amino-4-phosphonobutanoic acid--4.462024-11-27To be published
8WGBCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensGlutammateW9RGi3/β1/γ23.72024-10-30doi.org/10.1038/s41467-024-54744-7
8WGB (No Gprot) CAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensGlutammateW9R3.72024-10-30doi.org/10.1038/s41467-024-54744-7
8JD2CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamate--2.82023-06-2110.1038/s41422-023-00830-2
8JD1CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamate--3.72023-06-2110.1038/s41422-023-00830-2
8JD0CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateNAM563-3.32023-06-2110.1038/s41422-023-00830-2
8JCZCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCYCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--2.92023-06-2110.1038/s41422-023-00830-2
8JCXCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCWCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCVCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--3.42023-06-2110.1038/s41422-023-00830-2
8JCUCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--2.82023-06-2110.1038/s41422-023-00830-2
8JD4CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamate--2.92023-06-2110.1038/s41422-023-00830-2
8JD3CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateHZR; PEFGi1/β1/γ23.32023-06-2110.1038/s41422-023-00830-2
8JD3 (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateHZR; PEF3.32023-06-2110.1038/s41422-023-00830-2
8JD5CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamateBQI; HZE; PEFGi1/β1/γ23.62023-06-2110.1038/s41422-023-00830-2
8JD5 (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamateBQI; HZE; PEF3.62023-06-2110.1038/s41422-023-00830-2
7MTRCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164-3.32021-07-0710.1038/s41586-021-03680-3
7MTQCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensLY341495--3.652021-07-0710.1038/s41586-021-03680-3
7MTSCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164Gi1/β1/γ23.22021-07-0710.1038/s41586-021-03680-3
7MTS (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX551643.22021-07-0710.1038/s41586-021-03680-3
7EPFCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiens-NAM597-2.72021-06-2310.1038/s41586-021-03641-w
7EPECAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiens-NAM563-2.52021-06-2310.1038/s41586-021-03641-w
7EPBCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetad--3.12021-06-2310.1038/s41586-021-03641-w
7EPACAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiens---3.62021-06-2310.1038/s41586-021-03641-w
7EPDCAminoacidMetabotropic GlutamatemGlu2, mGlu7Homo sapiens---3.92021-06-2310.1038/s41586-021-03641-w
7E9GCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetadJNJ-40411813Gi1/β1/γ23.52021-06-2310.1038/s41586-021-03495-2
7E9G (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetadJNJ-404118133.52021-06-2310.1038/s41586-021-03495-2




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