Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:E1 7.09667920
2M:M:E1 6.17710
3R:R:L26 4.644525
4R:R:L32 6.624145
5R:R:F38 6.705428
6R:R:V40 6.2426
7R:R:H41 5.94628
8R:R:D49 7.115421
9R:R:V53 4.63423
10R:R:R57 8.83714724
11R:R:I59 4.36406
12R:R:Q60 4.78527
13R:R:R61 6.24778924
14R:R:E63 4.56833628
15R:R:M65 4.8675429
16R:R:L66 3.18525
17R:R:F67 9.0975427
18R:R:L78 5.18333627
19R:R:L79 4.325409
20R:R:V82 6.22754145
21R:R:H87 4.544524
22R:R:I88 4.28167627
23R:R:L89 6.026525
24R:R:D90 7.845429
25R:R:C92 5.2428
26R:R:K94 4.585423
27R:R:H97 6.228523
28R:R:F105 7.288526
29R:R:I140 3.37427
30R:R:S143 5.874524
31R:R:Y144 7.29833623
32R:R:I149 6.7425
33R:R:L155 5.3825426
34R:R:R156 7.4675425
35R:R:L157 3.684525
36R:R:F158 5.94667626
37R:R:Q162 4.914528
38R:R:I163 3.475627
39R:R:Y165 7.41628
40R:R:A166 4.0675425
41R:R:S169 5.085427
42R:R:K171 5.626523
43R:R:L172 6.856527
44R:R:R177 6.73425
45R:R:Y178 7.132526
46R:R:Y180 7.844226
47R:R:F181 8.565429
48R:R:R183 6.68529
49R:R:F190 3.9475405
50R:R:Q191 8.268528
51R:R:K193 4.48423
52R:R:M195 3.1825407
53R:R:E197 6.192526
54R:R:I198 4.286528
55R:R:L199 4.4526
56R:R:F202 5.835628
57R:R:W204 6.52667629
58R:R:Y206 6.1875409
59R:R:T209 4.624526
60R:R:Y216 5.924527
61R:R:I221 3.938505
62R:R:F224 3.195427
63R:R:E239 5.665405
64R:R:V265 5.65428
65R:R:V267 4.0625426
66R:R:F269 5.435407
67R:R:R271 9.7975425
68R:R:D274 4.9525404
69R:R:R284 6.2475403
70R:R:F289 5.52667646
71R:R:W291 5.815647
72R:R:D295 7.84528
73R:R:W297 5.46946
74R:R:L300 4.936525
75R:R:I317 3.0575426
76R:R:E318 8.3725406
77R:R:L319 4.67524
78R:R:I324 4.176526
79R:R:D326 5.9425424
80R:R:F327 4.94286728
81R:R:Y330 5.8875428
82R:R:F331 4.71167626
83R:R:L334 4.81425
84R:R:P336 10.2975426
85R:R:N339 5.152524
86R:R:R341 6.385404
87R:R:N342 5.10286727
88R:R:P343 5.64422
89R:R:W344 6.58429724
90R:R:F345 5.10833624
91R:R:F348 6.874526
92R:R:W349 11.0575428
93R:R:R352 7.244523
94R:R:F353 8.375627
95R:R:C362 6.7525429
96R:R:L367 3.3475426
97R:R:F372 6.836525
98R:R:Q374 5.762525
99R:R:E375 4.898525
100R:R:K377 5.835623
101R:R:I378 5.126527
102R:R:M379 7.785428
103R:R:F380 6.106526
104R:R:V382 3.44428
105R:R:Y386 7.29833626
106R:R:M388 5.19426
107R:R:M410 4.1954252
108R:R:R417 6.16754166
109R:R:Y419 4.63505
110R:R:F422 5.3425164
111R:R:V423 3.2406
112R:R:F428 8.835428
113R:R:P431 6.782527
114R:R:F432 5.55167624
115R:R:F443 2.94333628
116R:R:D448 5.45333627
117R:R:R452 5.505444
118R:R:Y453 4.865628
119R:R:N454 5.34447
120R:R:F456 6.3975445
121R:R:Y466 6.962542
122R:R:R467 6.02422
123R:R:Y468 5.35857744
124R:R:K470 4.7075445
125R:R:V471 4.5975407
126R:R:W474 7.68526
127R:R:L478 6.282526
128R:R:I485 6.7425427
129R:R:W487 4.79857727
130R:R:E529 7.635478
131R:R:Y530 8.588577
132R:R:W545 4.235406
133R:R:P546 3.93478
134R:R:F589 3.95667689
135R:R:S601 4.4325409
136R:R:L605 4.524128
137R:R:V613 4.4825408
138R:R:F614 4.37405
139R:R:M619 3.195457
140R:R:F623 4.405458
141R:R:V631 4.90754267
142R:R:C632 3.87254139
143R:R:R636 9.845408
144R:R:L639 4.925458
145R:R:F643 6.538558
146R:R:Y647 8.042556
147R:R:R659 3.444127
148R:R:F661 5.7054199
149R:R:I674 4.47754126
150R:R:Q679 6.416128
151R:R:C683 3.35407
152R:R:Q690 5.06833659
153R:R:P703 4.4325409
154R:R:T705 3.7854134
155R:R:R724 5.0375458
156R:R:D725 7.89833654
157R:R:N735 5.98457
158R:R:Y745 5.654507
159R:R:F756 4.27754199
160R:R:I762 2.446589
161R:R:Y767 8.566539
162R:R:I772 3.795408
163R:R:W773 8.644559
164R:R:F776 4.65167659
165R:R:F780 6.32658
166R:R:V789 6.364555
167R:R:Q790 5.2975457
168R:R:M794 3.84459
169R:R:L809 4.005488
170R:R:F810 4.374589
171R:R:I817 3.00754279
172S:S:E32 6.784514
173S:S:I33 3.5675415
174S:S:K34 3.765414
175S:S:L39 3.5625415
176S:S:L41 3.53417
177S:S:F45 5.51618
178S:S:P46 4.6025416
179S:S:I47 7.552515
180S:S:N48 5.742519
181S:S:I60 4.9225404
182S:S:R64 10.005415
183S:S:Q67 3.97286717
184S:S:R68 7.27167614
185S:S:E70 4.70375818
186S:S:M72 4.76417
187S:S:L73 5.175414
188S:S:F74 9.1075417
189S:S:E78 8.1875418
190S:S:I79 8419
191S:S:L85 6.274516
192S:S:L91 4.184508
193S:S:H94 5.608514
194S:S:I95 4.34833617
195S:S:L96 6.4975414
196S:S:D97 8.9925418
197S:S:C99 7.4175416
198S:S:R101 5.335403
199S:S:D102 6.8325423
200S:S:T103 5.6475423
201S:S:Q108 8.0325416
202S:S:E111 6.102514
203S:S:F112 5.50286715
204S:S:S149 4.64667615
205S:S:Y150 6.542514
206S:S:S154 4.3625417
207S:S:I155 5.9925415
208S:S:V157 4.82415
209S:S:L161 6.0475417
210S:S:R162 4.8254154
211S:S:L163 3.6845155
212S:S:F164 5.9756155
213S:S:P167 3.702508
214S:S:Q168 5.536518
215S:S:I169 3.89417
216S:S:Y171 6.30571716
217S:S:A172 3.918515
218S:S:S173 4.4175417
219S:S:T174 5.43418
220S:S:K177 6.8325414
221S:S:L178 7.486518
222S:S:R183 8.7175405
223S:S:Y184 8.7825416
224S:S:Y186 10.99406
225S:S:F187 8.414518
226S:S:R189 5.94619
227S:S:V191 3.6375407
228S:S:P192 4.12518
229S:S:D194 7.555418
230S:S:Y196 4.148514
231S:S:Q197 9.6775419
232S:S:M201 4.71254107
233S:S:I204 3.1225467
234S:S:L205 3.594106
235S:S:R206 3.455405
236S:S:F208 8.032568
237S:S:W210 9.482569
238S:S:Y212 5.728336289
239S:S:T215 4.5285106
240S:S:E219 6.79254116
241S:S:Y222 5.644507
242S:S:T225 3.4275414
243S:S:F230 5.6745106
244S:S:E233 5.828515
245S:S:E245 7.8925415
246S:S:K246 9.19754114
247S:S:R253 6.4465112
248S:S:Y256 6.17502
249S:S:V259 5.205416
250S:S:I260 1.62405
251S:S:E262 6.39414
252S:S:L263 2.85416
253S:S:V271 7.5675468
254S:S:V272 3.584516
255S:S:V273 5.285106
256S:S:L274 4.6425415
257S:S:F275 4.9856108
258S:S:R277 8.21514
259S:S:I285 3.496514
260S:S:F295 3.285419
261S:S:W297 5.24667617
262S:S:S300 4.15754108
263S:S:D301 6.04418
264S:S:W303 6.415817
265S:S:I309 6.208514
266S:S:I310 4.75412
267S:S:E324 4.956516
268S:S:L325 5.47415
269S:S:F333 7.21571717
270S:S:Y336 6.955418
271S:S:F337 5.795616
272S:S:L340 5.57414
273S:S:N345 6.285413
274S:S:R347 6.9975403
275S:S:N348 6.05833617
276S:S:P349 3.7775412
277S:S:W350 7.30667615
278S:S:F351 6.78667615
279S:S:F354 7.5406
280S:S:W355 12.8975417
281S:S:F359 7.82833618
282S:S:I379 4.31415
283S:S:Y384 6.59429715
284S:S:Q386 6.84429716
285S:S:E387 3.33415
286S:S:K389 5.845614
287S:S:I390 7.684516
288S:S:F392 5.03667617
289S:S:Y398 8.65833618
290S:S:M400 3.22571716
291S:S:H402 10.585417
292S:S:L404 4.1675418
293S:S:C419 3.085407
294S:S:L425 2.4875413
295S:S:K429 6.1254207
296S:S:Y431 4.05705
297S:S:Y434 6.89754205
298S:S:L435 3.764517
299S:S:F440 10.034518
300S:S:P443 6.98514
301S:S:F444 5.87429715
302S:S:N445 6.3525404
303S:S:F456 2.894518
304S:S:D461 5.508518
305S:S:R465 4.735414
306S:S:Y466 7.448519
307S:S:N467 5.08417
308S:S:F469 4.864515
309S:S:N470 5.1725468
310S:S:Q472 9.7325406
311S:S:Y478 13.12754293
312S:S:Y480 6.845614
313S:S:V483 3.8675468
314S:S:W486 6.5225405
315S:S:L490 4.3625466
316S:S:L492 4.584566
317S:S:W499 8.89567
318S:S:M518 5.2554176
319S:S:W529 8.7754177
320S:S:C531 4.074179
321S:S:E538 4.79754317
322S:S:F544 6.5225403
323S:S:W554 7.284327
324S:S:C562 5.00254219
325S:S:L565 3.184328
326S:S:W576 5.3225496
327S:S:K608 12.83754347
328S:S:L614 5.105408
329S:S:S625 2.98537
330S:S:Y626 4.96556938
331S:S:F632 7.528508
332S:S:F652 4.85638
333S:S:Q688 5.02754368
334S:S:Y717 5.35497
335S:S:I727 8.3475495
336S:S:V732 6.59254356
337S:S:M737 2.565407
338S:S:F765 5.23409
339S:S:K769 4.805439
340S:S:F773 5.8525439
341S:S:M775 4.40857709
342S:S:Y776 2.812509
343S:S:W782 4.695609
344S:S:F785 6.6725189
345S:S:F789 7.0385188
346S:S:Y796 9.3225495
347S:S:R797 7.988595
348S:S:F812 4.272537
349S:S:V813 7.4525438
350S:S:L815 4.2325438
351S:S:F819 5.938539
352W:W:?1 8.452311350
353X:X:?1 5.846251630
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:E1 R:R:S145 77.46112.87YesNo208
2R:R:S145 R:R:S169 80.85166.52NoYes287
3R:R:K171 R:R:S169 38.11366.12YesYes237
4R:R:K171 R:R:Y178 38.10314.78YesYes236
5R:R:R177 R:R:Y178 80.4247.2YesYes256
6R:R:R177 S:S:T103 65.34285.17YesYes253
7S:S:R101 S:S:T103 72.11027.76YesYes033
8S:S:K50 S:S:R101 51.86564.95NoYes033
9S:S:K50 S:S:R277 51.7476.19NoYes034
10S:S:R277 S:S:Y150 50.028515.43YesYes144
11S:S:S149 S:S:Y150 47.30582.54YesYes154
12M:M:E1 S:S:S149 25.05875.75YesYes105
13R:R:L172 R:R:S169 42.72454.5YesYes277
14R:R:L172 R:R:Y178 42.44277.03YesYes276
15M:M:E1 S:S:R64 27.08649.3YesYes105
16S:S:R68 S:S:S149 21.49033.95YesYes145
17S:S:R64 S:S:R68 20.363911.73YesYes154
18R:R:R177 S:S:D102 14.992711.91YesYes253
19S:S:D102 S:S:S152 16.08724.42YesNo034
20S:S:D221 S:S:S152 16.0152.94NoNo064
21S:S:L178 S:S:R189 11.39246.07YesYes189
22S:S:D221 S:S:K177 10.941112.44NoYes164
23S:S:K177 S:S:S175 10.58433.06YesNo147
24S:S:S151 S:S:S175 10.73266.52NoNo097
25S:S:S151 S:S:Y222 17.37525.09NoYes097
26L:L:E1 R:R:R57 72.943116.28YesYes204
27R:R:C92 R:R:H41 15.21882.95YesYes288
28R:R:F331 R:R:I59 11.42262.51YesYes066
29R:R:C92 R:R:H97 24.35455.9YesYes283
30R:R:H97 R:R:K94 24.11322.62YesYes233
31S:S:R183 S:S:Y184 13.684210.29YesYes056
32R:R:L300 R:R:R57 77.411712.15YesYes254
33R:R:H56 R:R:L300 13.06862.57NoYes235
34R:R:H56 R:R:Q60 13.16774.95NoYes237
35R:R:K94 R:R:T96 17.19874.5YesNo032
36R:R:L300 R:R:V303 98.00412.98YesNo054
37R:R:V303 R:R:W297 97.800613.48NoYes046
38R:R:W291 R:R:W297 99.2823.75YesYes476
39R:R:F289 R:R:W291 10014.03YesYes467
40R:R:F289 R:R:L257 98.51722.44YesNo067
41R:R:L257 R:R:S208 98.00034.5NoNo078
42R:R:S208 R:R:T237 97.77053.2NoNo086
43R:R:K260 R:R:T237 97.65554.5NoNo046
44R:R:K260 R:R:Y206 97.42522.39NoYes049
45R:R:C500 R:R:Y206 97.07928.06NoYes099
46R:R:C500 R:R:C519 96.96377.28NoNo099
47R:R:C519 R:R:S501 96.84823.44NoNo098
48R:R:S501 R:R:W520 96.73253.71NoNo087
49R:R:S511 R:R:W520 93.462311.12NoNo057
50R:R:C522 R:R:S511 93.34435.16NoNo095
51R:R:C522 R:R:V509 93.10823.42NoNo096
52R:R:P524 R:R:V509 92.87181.77NoNo036
53R:R:I523 R:R:P524 92.75351.69NoNo043
54R:R:I523 R:R:K510 10.17672.91NoNo047
55R:R:I523 S:S:I532 85.26282.94NoNo044
56S:S:I532 S:S:P533 85.13951.69NoNo043
57S:S:M518 S:S:P533 85.016211.74YesNo063
58S:S:C531 S:S:M518 84.37543.24YesYes1796
59S:S:C531 S:S:N520 83.83453.15YesNo1795
60S:S:F544 S:S:N520 83.75567.25YesNo035
61S:S:D542 S:S:F544 83.57435.97NoYes073
62S:S:D542 S:S:T545 83.44997.23NoNo075
63S:S:M547 S:S:T545 83.32536.02NoNo035
64S:S:A541 S:S:M547 83.20064.83NoNo083
65S:S:A541 S:S:Y539 83.07594NoNo088
66S:S:C562 S:S:Y539 82.50994.03YesNo2198
67S:S:C562 S:S:P555 82.15675.65YesNo098
68S:S:P555 S:S:W554 80.14299.46NoYes087
69S:S:E724 S:S:W554 78.8745.45NoYes047
70S:S:E724 S:S:T725 78.74662.82NoNo045
71S:S:T725 S:S:Y569 78.61929.99NoNo057
72S:S:Y569 S:S:Y796 67.51178.94NoYes975
73S:S:R797 S:S:Y796 67.421110.29YesYes955
74S:S:R797 S:S:W576 65.98583YesYes956
75S:S:D574 S:S:W576 65.94354.47NoYes076
76S:S:A577 S:S:D574 65.811.54NoNo077
77S:S:A577 S:S:I633 65.67683.25NoNo078
78S:S:I633 S:S:V581 65.54441.54NoNo086
79S:S:F630 S:S:V581 65.41253.93NoNo076
80S:S:F588 S:S:F630 65.14994.29NoNo067
81S:S:F588 S:S:Y626 62.71673.09NoYes068
82S:S:F812 S:S:Y626 50.49017.22YesYes378
83S:S:F812 X:X:?1 49.95793.46YesYes370
84R:R:T743 X:X:?1 32.17832.09NoYes080
85R:R:M766 R:R:T743 31.86943.01NoNo098
86R:R:I739 R:R:M766 31.25878.75NoNo089
87R:R:I739 R:R:Y647 31.106313.3NoYes086
88R:R:Y647 W:W:?1 19.62388.96YesYes560
89R:R:K760 X:X:?1 11.66247.01NoYes090
90R:R:F761 R:R:K760 11.49736.2NoNo059
91R:R:F761 R:R:P812 11.332713NoNo059
92R:R:A811 R:R:P812 11.16961.87NoNo039
93R:R:A811 R:R:G807 11.01411.95NoNo031
94R:R:G807 R:R:L806 10.8641.71NoNo018
95R:R:L806 R:R:V613 10.71398.94NoYes088
96S:S:I727 S:S:Y569 10.986.04YesNo957
97S:S:I727 S:S:Y717 10.76513.63YesYes957
98S:S:N731 S:S:Y717 10.32232.33NoYes067
99S:S:N731 S:S:R715 10.19647.23NoNo063
100S:S:R101 S:S:Y104 20.31045.14YesNo033
101S:S:C99 S:S:Y104 17.345816.13YesNo063
102S:S:E324 S:S:K389 11.90224.05YesYes164
103S:S:R64 S:S:S278 23.61352.64YesNo153
104S:S:Q306 S:S:R64 23.613516.35NoYes155
105S:S:S300 S:S:Y222 19.47435.09YesYes087
106S:S:F275 S:S:S300 11.15446.61YesYes1088
107S:S:I309 S:S:S278 23.39084.64YesNo143
108S:S:I309 S:S:W303 45.81248.22YesYes147
109S:S:W297 S:S:W303 32.39827.5YesYes177
110S:S:V272 S:S:W297 23.99526.13YesYes167
111S:S:V216 S:S:V259 20.26093.21NoYes156
112S:S:E245 S:S:V259 21.10348.56YesYes156
113S:S:E245 S:S:E262 19.18597.61YesYes154
114S:S:E262 S:S:K266 19.11992.7YesNo043
115S:S:K266 S:S:Y212 14.34042.39NoYes039
116S:S:I309 S:S:Q306 23.39088.23YesNo145
117S:S:L274 S:S:V216 14.64894.47YesNo155
118S:S:L263 S:S:V272 12.70592.98YesYes166
119S:S:E324 S:S:F469 11.34453.5YesYes165
120R:R:F331 R:R:Q60 10.52173.51YesYes267
121S:S:L178 S:S:Y184 13.73477.03YesYes186
122M:M:E1 S:S:Y222 10.71034.49YesYes007
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
M:M:E1 S:S:R64 9.3 1 Yes Yes 0 5 0 1
M:M:E1 S:S:R68 8.14 1 Yes Yes 0 4 0 1
M:M:E1 S:S:S149 5.75 1 Yes Yes 0 5 0 1
M:M:E1 S:S:A172 4.53 1 Yes Yes 0 5 0 1
M:M:E1 S:S:T174 4.23 1 Yes Yes 0 8 0 1
M:M:E1 S:S:Y222 4.49 1 Yes Yes 0 7 0 1
M:M:E1 S:S:K389 6.75 1 Yes Yes 0 4 0 1
S:S:P46 S:S:S149 7.13 1 Yes Yes 6 5 2 1
S:S:P46 S:S:Y150 4.17 1 Yes Yes 6 4 2 2
S:S:P46 S:S:Y171 2.78 1 Yes Yes 6 6 2 2
S:S:R64 S:S:R68 11.73 1 Yes Yes 5 4 1 1
S:S:R64 S:S:S278 2.64 1 Yes No 5 3 1 2
S:S:Q306 S:S:R64 16.35 1 No Yes 5 5 2 1
S:S:R68 S:S:S149 3.95 1 Yes Yes 4 5 1 1
S:S:R68 S:S:Y171 8.23 1 Yes Yes 4 6 1 2
S:S:A172 S:S:R68 4.15 1 Yes Yes 5 4 1 1
S:S:K389 S:S:R68 7.43 1 Yes Yes 4 4 1 1
S:S:S149 S:S:Y150 2.54 1 Yes Yes 5 4 1 2
S:S:S149 S:S:Y171 5.09 1 Yes Yes 5 6 1 2
S:S:A172 S:S:S149 3.42 1 Yes Yes 5 5 1 1
S:S:S151 S:S:Y222 5.09 0 No Yes 9 7 2 1
S:S:A172 S:S:Y171 2.67 1 Yes Yes 5 6 1 2
S:S:A172 S:S:K389 4.82 1 Yes Yes 5 4 1 1
S:S:T174 S:S:V191 3.17 1 Yes Yes 8 7 1 2
S:S:D194 S:S:T174 7.23 1 Yes Yes 8 8 2 1
S:S:Q197 S:S:T174 7.09 1 Yes Yes 9 8 2 1
S:S:F392 S:S:V191 3.93 1 Yes Yes 7 7 2 2
S:S:D194 S:S:Q197 10.44 1 Yes Yes 8 9 2 2
S:S:D194 S:S:Y222 9.2 1 Yes Yes 8 7 2 1
S:S:D301 S:S:Q197 6.53 1 Yes Yes 8 9 2 2
S:S:G223 S:S:Y222 4.35 0 No Yes 7 7 2 1
S:S:S300 S:S:Y222 5.09 10 Yes Yes 8 7 2 1
S:S:Q306 S:S:S278 4.33 1 No No 5 3 2 2
S:S:D301 S:S:E324 3.9 1 Yes Yes 8 6 2 2
S:S:D301 S:S:K389 8.3 1 Yes Yes 8 4 2 1
S:S:E324 S:S:K389 4.05 1 Yes Yes 6 4 2 1
S:S:F392 S:S:K389 3.72 1 Yes Yes 7 4 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M766 R:R:T743 3.01 0 No No 9 8 2 1
R:R:F747 R:R:R750 5.34 3 No No 8 9 1 1
R:R:F747 X:X:?1 5.19 3 No Yes 8 0 1 0
R:R:K751 R:R:R750 4.95 0 No No 7 9 2 1
R:R:R750 X:X:?1 10.35 3 No Yes 9 0 1 0
R:R:F761 R:R:K760 6.2 0 No No 5 9 2 1
R:R:K760 X:X:?1 7.01 0 No Yes 9 0 1 0
R:R:F764 S:S:F773 5.36 3 No Yes 9 9 1 1
R:R:F764 X:X:?1 6.92 3 No Yes 9 0 1 0
R:R:I771 R:R:Y767 13.3 0 No Yes 8 9 2 1
R:R:Y767 S:S:T777 6.24 3 Yes No 9 8 1 2
R:R:Y767 S:S:I781 2.42 3 Yes No 9 9 1 2
R:R:Y767 S:S:V813 5.05 3 Yes Yes 9 8 1 1
R:R:Y767 X:X:?1 15.82 3 Yes Yes 9 0 1 0
R:R:C770 X:X:?1 3.38 0 No Yes 7 0 1 0
S:S:F812 S:S:I583 2.51 3 Yes No 7 3 1 2
S:S:F812 S:S:L586 3.65 3 Yes No 7 3 1 2
S:S:G587 S:S:Y626 8.69 3 No Yes 6 8 2 2
S:S:F812 S:S:G587 4.52 3 Yes No 7 6 1 2
S:S:F812 S:S:Y626 7.22 3 Yes Yes 7 8 1 2
S:S:K769 S:S:N766 2.8 3 Yes No 9 9 1 2
S:S:F770 S:S:K769 8.69 3 No Yes 4 9 1 1
S:S:F773 S:S:K769 3.72 3 Yes Yes 9 9 1 1
S:S:K769 X:X:?1 4.01 3 Yes Yes 9 0 1 0
S:S:F770 S:S:P821 8.67 3 No No 4 9 1 2
S:S:F770 X:X:?1 6.05 3 No Yes 4 0 1 0
S:S:F773 S:S:Y776 3.09 3 Yes Yes 9 9 1 2
S:S:F773 X:X:?1 11.24 3 Yes Yes 9 0 1 0
S:S:C817 S:S:T774 6.76 0 No No 7 9 1 2
S:S:T777 S:S:V813 11.11 3 No Yes 8 8 2 1
S:S:I781 S:S:V813 3.07 3 No Yes 9 8 2 1
S:S:F812 X:X:?1 3.46 3 Yes Yes 7 0 1 0
S:S:V813 X:X:?1 10.58 3 Yes Yes 8 0 1 0
S:S:C817 X:X:?1 2.25 0 No Yes 7 0 1 0
R:R:A759 X:X:?1 2.24 0 No Yes 9 0 1 0
R:R:T743 X:X:?1 2.09 0 No Yes 8 0 1 0
S:S:L809 X:X:?1 1.97 0 No Yes 7 0 1 0
R:R:A740 R:R:T743 1.68 0 No No 3 8 2 1
R:R:L774 X:X:?1 0.98 0 No Yes 5 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:E1 R:R:R57 16.28 2 Yes Yes 0 4 0 1
L:L:E1 R:R:R61 10.47 2 Yes Yes 0 4 0 1
L:L:E1 R:R:S143 7.19 2 Yes Yes 0 4 0 1
L:L:E1 R:R:Y144 4.49 2 Yes Yes 0 3 0 1
L:L:E1 R:R:S145 2.87 2 Yes No 0 8 0 1
L:L:E1 R:R:A166 6.03 2 Yes Yes 0 5 0 1
L:L:E1 R:R:Y216 4.49 2 Yes Yes 0 7 0 1
L:L:E1 R:R:D295 2.6 2 Yes Yes 0 8 0 1
L:L:E1 R:R:K377 9.45 2 Yes Yes 0 3 0 1
R:R:P39 R:R:S143 7.13 0 No Yes 5 4 2 1
R:R:P39 R:R:Y144 4.17 0 No Yes 5 3 2 1
R:R:N54 R:R:R57 3.62 0 No Yes 4 4 2 1
R:R:R57 R:R:R61 9.6 2 Yes Yes 4 4 1 1
R:R:R57 R:R:S272 7.91 2 Yes No 4 2 1 2
R:R:G296 R:R:R57 3 0 No Yes 5 4 2 1
R:R:L300 R:R:R57 12.15 2 Yes Yes 5 4 2 1
R:R:E375 R:R:R57 9.3 2 Yes Yes 5 4 2 1
R:R:R61 R:R:S143 5.27 2 Yes Yes 4 4 1 1
R:R:R61 R:R:Y165 8.23 2 Yes Yes 4 8 1 2
R:R:A166 R:R:R61 4.15 2 Yes Yes 5 4 1 1
R:R:E375 R:R:R61 4.65 2 Yes Yes 5 4 2 1
R:R:K377 R:R:R61 7.43 2 Yes Yes 3 4 1 1
R:R:I378 R:R:R61 2.51 2 Yes Yes 7 4 2 1
R:R:R61 R:R:V381 3.92 2 Yes No 4 7 1 2
R:R:S93 R:R:Y144 10.17 0 No Yes 1 3 2 1
R:R:S143 R:R:Y165 6.36 2 Yes Yes 4 8 1 2
R:R:A166 R:R:S143 3.42 2 Yes Yes 5 4 1 1
R:R:D146 R:R:Y144 3.45 2 No Yes 5 3 2 1
R:R:V147 R:R:Y144 5.05 2 No Yes 4 3 2 1
R:R:R271 R:R:Y144 16.46 2 Yes Yes 5 3 2 1
R:R:S145 R:R:S169 6.52 2 No Yes 8 7 1 2
R:R:S145 R:R:Y216 5.09 2 No Yes 8 7 1 1
R:R:D146 R:R:V147 4.38 2 No No 5 4 2 2
R:R:D146 R:R:R271 7.15 2 No Yes 5 5 2 2
R:R:A166 R:R:Y165 2.67 2 Yes Yes 5 8 1 2
R:R:V381 R:R:Y165 8.83 2 No Yes 7 8 2 2
R:R:D188 R:R:T168 7.23 0 No No 8 7 2 2
R:R:D295 R:R:T168 10.12 2 Yes No 8 7 1 2
R:R:D188 R:R:Q191 7.83 0 No Yes 8 8 2 2
R:R:D188 R:R:Y216 6.9 0 No Yes 8 7 2 1
R:R:Q191 R:R:S294 7.22 2 Yes No 8 8 2 2
R:R:D295 R:R:Q191 15.66 2 Yes Yes 8 8 1 2
R:R:S294 R:R:Y216 5.09 0 No Yes 8 7 2 1
R:R:D295 R:R:Y216 8.05 2 Yes Yes 8 7 1 1
R:R:L300 R:R:S272 3 2 Yes No 5 2 2 2
R:R:D295 R:R:K377 2.77 2 Yes Yes 8 3 1 1
R:R:E375 R:R:L300 3.98 2 Yes Yes 5 5 2 2
R:R:K377 R:R:L319 7.05 2 Yes Yes 3 4 1 2
R:R:F380 R:R:L319 4.87 2 Yes Yes 6 4 2 2
R:R:E375 R:R:I378 4.1 2 Yes Yes 5 7 2 2
R:R:K377 R:R:S376 4.59 2 Yes No 3 5 1 2
R:R:F380 R:R:K377 3.72 2 Yes Yes 6 3 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F623 R:R:M619 4.98 5 Yes Yes 8 7 2 2
R:R:L639 R:R:M619 2.83 5 Yes Yes 8 7 1 2
R:R:F623 R:R:L639 4.87 5 Yes Yes 8 8 2 1
R:R:F623 R:R:M794 4.98 5 Yes Yes 8 9 2 2
R:R:L639 R:R:M728 5.65 5 Yes No 8 7 1 1
R:R:L639 W:W:?1 6.35 5 Yes Yes 8 0 1 0
R:R:G640 R:R:Q690 3.29 0 No Yes 6 9 1 2
R:R:G640 W:W:?1 2.61 0 No Yes 6 0 1 0
R:R:F643 R:R:Y647 7.22 5 Yes Yes 8 6 1 1
R:R:F643 R:R:N735 2.42 5 Yes Yes 8 7 1 1
R:R:F643 R:R:W773 7.02 5 Yes Yes 8 9 1 1
R:R:F643 R:R:V798 3.93 5 Yes No 8 8 1 2
R:R:F643 W:W:?1 12.1 5 Yes Yes 8 0 1 0
R:R:Q690 R:R:S644 5.78 5 Yes No 9 8 2 2
R:R:N735 R:R:S644 2.98 5 Yes No 7 8 1 2
R:R:N735 R:R:Y647 6.98 5 Yes Yes 7 6 1 1
R:R:I739 R:R:Y647 13.3 0 No Yes 8 6 2 1
R:R:T769 R:R:Y647 3.75 0 No Yes 8 6 2 1
R:R:Y647 W:W:?1 8.96 5 Yes Yes 6 0 1 0
R:R:Q690 R:R:S731 8.66 5 Yes No 9 7 2 1
R:R:R720 R:R:R724 5.33 5 No Yes 6 8 2 2
R:R:D725 R:R:R720 3.57 5 Yes No 4 6 1 2
R:R:D725 R:R:R724 5.96 5 Yes Yes 4 8 1 2
R:R:F780 R:R:R724 7.48 5 Yes Yes 8 8 1 2
R:R:D725 R:R:M728 2.77 5 Yes No 4 7 1 1
R:R:D725 R:R:F780 14.33 5 Yes Yes 4 8 1 1
R:R:D725 R:R:M794 4.16 5 Yes Yes 4 9 1 2
R:R:D725 W:W:?1 16.6 5 Yes Yes 4 0 1 0
R:R:M728 W:W:?1 4.32 5 No Yes 7 0 1 0
R:R:S731 W:W:?1 3.44 0 No Yes 7 0 1 0
R:R:L732 W:W:?1 12.69 0 No Yes 8 0 1 0
R:R:N735 W:W:?1 11.54 5 Yes Yes 7 0 1 0
R:R:F776 R:R:W773 7.02 5 Yes Yes 9 9 1 1
R:R:S797 R:R:W773 3.71 5 No Yes 9 9 2 1
R:R:S801 R:R:W773 3.71 0 No Yes 9 9 2 1
R:R:W773 W:W:?1 21.76 5 Yes Yes 9 0 1 0
R:R:F776 R:R:F780 4.29 5 Yes Yes 9 8 1 1
R:R:F776 R:R:T793 5.19 5 Yes No 9 8 1 2
R:R:F776 R:R:M794 3.73 5 Yes Yes 9 9 1 2
R:R:F776 R:R:S797 3.96 5 Yes No 9 9 1 2
R:R:F776 W:W:?1 3.72 5 Yes Yes 9 0 1 0
R:R:F780 R:R:Q790 4.68 5 Yes Yes 8 7 1 2
R:R:F780 R:R:M794 2.49 5 Yes Yes 8 9 1 2
R:R:F780 W:W:?1 4.65 5 Yes Yes 8 0 1 0
R:R:V736 W:W:?1 1.14 0 No Yes 5 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8JD3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.39
Number of Linked Nodes 1465
Number of Links 1910
Number of Hubs 353
Number of Links mediated by Hubs 1247
Number of Communities 36
Number of Nodes involved in Communities 522
Number of Links involved in Communities 829
Path Summary
Number Of Nodes in MetaPath 123
Number Of Links MetaPath 122
Number of Shortest Paths 4956434
Length Of Smallest Path 3
Average Path Length 42.3362
Length of Longest Path 104
Minimum Path Strength 1.185
Average Path Strength 5.73881
Maximum Path Strength 22.03
Minimum Path Correlation 0.7
Average Path Correlation 0.998025
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.5873
Average % Of Corr. Nodes 65.7131
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 54.616
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • glutamate receptor activity   • scaffold protein binding   • protein binding   • binding   • calcium channel activity   • monoatomic cation transmembrane transporter activity   • channel regulator activity   • monoatomic ion channel activity   • ion channel regulator activity   • calcium channel regulator activity   • monoatomic cation channel activity   • passive transmembrane transporter activity   • calcium ion transmembrane transporter activity   • inorganic molecular entity transmembrane transporter activity   • channel activity   • inorganic cation transmembrane transporter activity   • molecular function regulator activity   • monoatomic ion transmembrane transporter activity   • transporter activity   • metal ion transmembrane transporter activity   • transporter regulator activity   • transmembrane transporter activity   • group II metabotropic glutamate receptor activity   • G protein-coupled glutamate receptor activity   • adenylate cyclase inhibiting G protein-coupled glutamate receptor activity   • regulation of localization   • nitrogen compound transport   • regulation of cellular process   • transport   • regulation of glutamate secretion   • localization   • secretion by cell   • regulation of secretion by cell   • regulation of amino acid transport   • glutamate secretion   • regulation of biological process   • organic anion transport   • carboxylic acid transport   • secretion
Gene OntologyBiological Process• regulation of localization   • nitrogen compound transport   • regulation of cellular process   • transport   • regulation of glutamate secretion   • localization   • secretion by cell   • regulation of secretion by cell   • regulation of amino acid transport   • glutamate secretion   • regulation of biological process   • organic anion transport   • carboxylic acid transport   • secretion   • regulation of transport   • biological regulation   • export from cell   • establishment of localization   • regulation of secretion   • organic acid transport   • amino acid transport   • amine transport   • acidic amino acid transport   • regulation of organic acid transport   • dicarboxylic acid transport   • cellular process   • regulation of amine transport   • trans-synaptic signaling   • regulation of signaling   • modulation of chemical synaptic transmission   • signaling   • cell-cell signaling   • presynaptic modulation of chemical synaptic transmission   • chemical synaptic transmission   • cell communication   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • regulation of cell communication   • monoamine transport   • regulation of catecholamine secretion   • organic hydroxy compound transport   • dopamine transport   • catecholamine transport   • signal release   • dopamine secretion   • catecholamine secretion   • regulation of dopamine secretion   • response to stimulus   • regulation of response to stimulus   • response to chemical   • regulation of response to drug   • response to xenobiotic stimulus   • cellular response to stimulus   • positive regulation of cell communication   • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of signal transduction   • positive regulation of biological process   • regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • signal transduction   • positive regulation of cellular process   • positive regulation of intracellular signal transduction   • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of signaling   • regulation of molecular function   • negative regulation of lyase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • cellular response to stress   • response to stress   • intracellular amino acid homeostasis   • cellular homeostasis   • intracellular glutamate homeostasis   • chemical homeostasis   • homeostatic process   • intracellular chemical homeostasis   • biosynthetic process   • metabolic process   • macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • cell surface receptor signaling pathway   • glutamate receptor signaling pathway   • G protein-coupled glutamate receptor signaling pathway   • G protein-coupled receptor signaling pathway   • negative regulation of signaling   • negative regulation of biological process   • negative regulation of synaptic transmission   • negative regulation of cell communication   • negative regulation of cellular process   • regulation of biological quality   • regulation of synaptic plasticity   • long-term synaptic depression   • behavior   • adult behavior   • multicellular organismal process   • response to nicotine   • behavioral response to nicotine   • synaptic transmission, glutamatergic   • regulation of synaptic transmission, glutamatergic   • response to oxygen-containing compound   • response to nitrogen compound   • response to cocaine   • response to alkaloid   • cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • glial cell projection   • cell projection   • plasma membrane bounded cell projection   • astrocyte projection
Gene OntologyCellular Component• cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • glial cell projection   • cell projection   • plasma membrane bounded cell projection   • astrocyte projection   • presynapse   • presynaptic membrane   • somatodendritic compartment   • dendrite   • dendritic tree   • neuron projection   • glutamatergic synapse   • axon   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • glutamate receptor activity   • scaffold protein binding   • protein binding   • binding   • calcium channel activity   • monoatomic cation transmembrane transporter activity   • channel regulator activity   • monoatomic ion channel activity   • ion channel regulator activity   • calcium channel regulator activity   • monoatomic cation channel activity   • passive transmembrane transporter activity   • calcium ion transmembrane transporter activity   • inorganic molecular entity transmembrane transporter activity   • channel activity   • inorganic cation transmembrane transporter activity   • molecular function regulator activity   • monoatomic ion transmembrane transporter activity   • transporter activity   • metal ion transmembrane transporter activity   • transporter regulator activity   • transmembrane transporter activity   • group II metabotropic glutamate receptor activity   • G protein-coupled glutamate receptor activity   • adenylate cyclase inhibiting G protein-coupled glutamate receptor activity   • regulation of molecular function   • negative regulation of lyase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • biological regulation   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • cellular response to stimulus   • cellular response to stress   • response to stimulus   • response to stress   • cellular process   • trans-synaptic signaling   • regulation of biological process   • regulation of signaling   • regulation of cellular process   • modulation of chemical synaptic transmission   • signaling   • cell-cell signaling   • chemical synaptic transmission   • cell communication   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • postsynaptic modulation of chemical synaptic transmission   • regulation of cell communication   • biosynthetic process   • metabolic process   • macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • cell surface receptor signaling pathway   • glutamate receptor signaling pathway   • G protein-coupled glutamate receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • synaptic transmission, glutamatergic   • regulation of synaptic transmission, glutamatergic   • neuron spine   • dendritic spine   • postsynaptic density   • neuron to neuron synapse   • postsynaptic specialization   • organelle   • asymmetric synapse   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • ciliary basal body   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• Type 1 solute binding protein-like   • Type 1 solute binding protein-like   • Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Type 1 solute binding protein-like   • Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeHZR
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeHZR
NameJNJ-40411813
SynonymsJNJ-40411813
Identifier
FormulaC20 H25 Cl N2 O
Molecular Weight344.878
SMILES
PubChem25195461
Formal Charge0
Total Atoms49
Total Chiral Atoms0
Total Bonds51
Total Aromatic Bonds6

CodePEF
PDB ResiduesX:X:?1
Environment DetailsOpen EMBL-EBI Page
CodePEF
Name1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine
Synonyms3-[AMINOETHYLPHOSPHORYL]-[1,2-DI-PALMITOYL]-SN-GLYCEROL
Identifier
FormulaC37 H74 N O8 P
Molecular Weight691.959
SMILES
PubChem11802774
Formal Charge0
Total Atoms121
Total Chiral Atoms2
Total Bonds120
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ14416
Sequence
>8JD3_nogp_Chain_R
KKVLTLEGD LVLGGLFPV HQKGGPAED CGPVNEHRG IQRLEAMLF 
ALDRINRDP HLLPGVRLG AHILDSCSK DTHALEQAL DFVRASLTA 
ITGVIGGSY SDVSIQVAN LLRLFQIPQ ISYASTSAK LSDKSRYDY 
FARTVPPDF FQAKAMAEI LRFFNWTYV STVASEGDY GETGIEAFE 
LEARARNIC VATSEKVGR AMSRAAFEG VVRALLQKP SARVAVLFT 
RSEDARELL AASQRLNAS FTWVASDGW GALESVVAG SEGAAEGAI 
TIELASYPI SDFASYFQS LDPWNNSRN PWFREFWEQ RFRCSFRQR 
DCAAHSLRA VPFEQESKI MFVVNAVYA MAHALHNMH RALCPNTTR 
LCDAMRPVN GRRLYKDFV LNVKFDAPF RPADTHNEV RFDRFGDGI 
GRYNIFTYL RAGSGRYRY QKVGYWAEG LTLDTSLIP WASPSAGPL 
PASRCSEPC LQNEVKSVQ PGEVCCWLC IPCQPYEYR LDEFTCADC 
GLGYWPNAS LTGCFELPQ EYIRWGDAW AVGPVTIAC LGALATLFV 
LGVFVRHNA TPVVKASGR ELCYILLGG VFLCYCMTF IFIAKPSTA 
VCTLRRLGL GTAFSVCYS ALLTKTNRI ARIFGGARE GAQRPRFIS 
PASQVAICL ALISGQLLI VVAWLVVEA PGTGKETAP ERREVVTLR 
CNHRDASML GSLAYNVLL IALCTLYAF KTRKCPENF NEAKFIGFT 
MYTTCIIWL AFLPIFYVT SSDYRVQTT TMCVSVSLS GSVVLGCLF 
APKLHIILF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ14832
Sequence
>8JD3_nogp_Chain_S
RREIKIEGD LVLGGLFPI NEKGTGTEE CGRINEDRG IQRLEAMLF 
AIDEINKDD YLLPGVKLG VHILDTCSR DTYALEQSL EFVRASLIP 
LLIAGVIGG SYSSVSIQV ANLLRLFQI PQISYASTS AKLSDKSRY 
DYFARTVPP DFYQAKAMA EILRFFNWT YVSTVASEG DYGETGIEA 
FEQEARLRN ICIATAEKV GRSNIRKSY DSVIRELLQ KPNARVVVL 
FMRSDDSRE LIAAASRAN ASFTWVASD GWGAQESII KGSEHVAYG 
AITLELASQ PVRQFDRYF QSLNPYNNH RNPWFRDFW EQKFQCSLQ 
NKRNHRRVC DKHLAIDSS NYEQESKIM FVVNAVYAM AHALHKMQR 
TLCPNTTKL CDAMKILDG KKLYKDYLL KINFTAPFN PNKDADSIV 
KFDTFGDGM GRYNVFNFQ NVGGKYSYL KVGHWAETL SLDVNSIHW 
SRNSVPTSQ CSDPCAPNE MKNMQPGDV CCWICIPCE PYEYLADEF 
TCMDCGSGQ WPTADLTGC YDLPEDYIR WEDAWAIGP VTIACLGFM 
CTCMVVTVF IKHNNTPLV KASGRELCY ILLFGVGLS YCMTFFFIA 
KPSPVICAL RRLGLGSSF AICYSALLT KTNCISPSS QVFICLGLI 
LVQIVMVSV WLILEAPGT RRYTLAEKR ETVILKCNV KDSSMLISL 
TYDVILVIL CTVYAFKTR KCPENFNEA KFIGFTMYT TCIIWLAFL 
PIFYVTSSD YRVQTTTMC ISVSLSGFV VLGCLFAPK VHIILFQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WGDCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensWAG/WA6--4.452024-11-27To be published
8WGCCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensLY379268--5.952024-11-27To be published
8WG9CAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiens(2S)-2-amino-4-phosphonobutanoic acid--4.462024-11-27To be published
8WGBCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensGlutammateW9RGi3/β1/γ23.72024-10-30doi.org/10.1038/s41467-024-54744-7
8WGB (No Gprot) CAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensGlutammateW9R3.72024-10-30doi.org/10.1038/s41467-024-54744-7
8JD2CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamate--2.82023-06-2110.1038/s41422-023-00830-2
8JD1CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamate--3.72023-06-2110.1038/s41422-023-00830-2
8JD0CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateNAM563-3.32023-06-2110.1038/s41422-023-00830-2
8JCZCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCYCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--2.92023-06-2110.1038/s41422-023-00830-2
8JCXCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCWCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCVCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--3.42023-06-2110.1038/s41422-023-00830-2
8JCUCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--2.82023-06-2110.1038/s41422-023-00830-2
8JD4CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamate--2.92023-06-2110.1038/s41422-023-00830-2
8JD3CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateHZR; PEFGi1/β1/γ23.32023-06-2110.1038/s41422-023-00830-2
8JD3 (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateHZR; PEF3.32023-06-2110.1038/s41422-023-00830-2
8JD5CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamateBQI; HZE; PEFGi1/β1/γ23.62023-06-2110.1038/s41422-023-00830-2
8JD5 (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamateBQI; HZE; PEF3.62023-06-2110.1038/s41422-023-00830-2
7MTRCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164-3.32021-07-0710.1038/s41586-021-03680-3
7MTQCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensLY341495--3.652021-07-0710.1038/s41586-021-03680-3
7MTSCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164Gi1/β1/γ23.22021-07-0710.1038/s41586-021-03680-3
7MTS (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX551643.22021-07-0710.1038/s41586-021-03680-3
7EPFCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiens-NAM597-2.72021-06-2310.1038/s41586-021-03641-w
7EPECAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiens-NAM563-2.52021-06-2310.1038/s41586-021-03641-w
7EPBCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetad--3.12021-06-2310.1038/s41586-021-03641-w
7EPACAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiens---3.62021-06-2310.1038/s41586-021-03641-w
7EPDCAminoacidMetabotropic GlutamatemGlu2, mGlu7Homo sapiens---3.92021-06-2310.1038/s41586-021-03641-w
7E9GCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetadJNJ-40411813Gi1/β1/γ23.52021-06-2310.1038/s41586-021-03495-2
7E9G (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetadJNJ-404118133.52021-06-2310.1038/s41586-021-03495-2




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