CodeZ99
Name2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine
Synonyms(1S,2S)-2-[(2S)-2-amino-1-hydroxy-1-oxo-3-(9H-xanthen-9-yl)propan-2-yl]cyclopropane-1-carboxylic acid
Identifier(1S,2S)-2-[(2S)-2-azanyl-1-hydroxy-1-oxo-3-(9H-xanthen-9-yl)propan-2-yl]cyclopropane-1-carboxylic acid
FormulaC20 H19 N O5
Molecular Weight353.369
SMILESc1ccc2c(c1)C(c3ccccc3O2)C[C@]([C@H]4C[C@@H]4C(=O)O)(C(=O)O)N
PubChem9819927
Formal Charge0
Total Atoms45
Total Chiral Atoms3
Total Bonds48
Total Aromatic Bonds12
Networks10
 missing image

This ligand is also present in the following 10 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7FD9 C Aminoacid Metabotropic glutamate mGlu5; mGlu5 Homo sapiens LY341495 - - 4 2021-09-08 10.1016/j.celrep.2021.109648

A 2D representation of the interactions of Z99 in 7FD9
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S42 R:R:W100 8.65 0 No Yes 6 3 2 1
R:R:Q46 R:R:W100 3.29 27 No Yes 3 3 2 1
R:R:R61 R:R:Y64 12.35 0 No Yes 5 4 2 1
R:R:Q63 R:R:Y64 6.76 0 No Yes 2 4 2 1
R:R:R68 R:R:Y64 11.32 1 Yes Yes 4 4 2 1
L:L:?902 R:R:Y64 6.84 0 Yes Yes 0 4 0 1
R:R:S151 R:R:W100 8.65 0 No Yes 4 3 2 1
L:L:?902 R:R:W100 7.48 0 Yes Yes 0 3 0 1
R:R:S152 R:R:S176 4.89 0 No No 9 7 1 2
L:L:?902 R:R:S152 8.76 0 Yes No 0 9 0 1
R:R:T175 R:R:V192 3.17 0 No No 8 7 1 2
R:R:D195 R:R:T175 10.12 4 No No 8 8 2 1
L:L:?902 R:R:T175 9.68 0 Yes No 0 8 0 1
R:R:N222 R:R:S176 2.98 0 No No 6 7 1 2
R:R:D195 R:R:Y223 10.34 4 No Yes 8 7 2 1
R:R:D195 R:R:F277 5.97 4 No Yes 8 7 2 2
R:R:E279 R:R:T219 5.64 0 No No 4 5 1 2
L:L:?902 R:R:N222 3.01 0 Yes No 0 6 0 1
R:R:G224 R:R:Y223 4.35 4 No Yes 8 7 2 1
R:R:F277 R:R:Y223 15.47 4 Yes Yes 7 7 2 1
L:L:?902 R:R:Y223 27.37 0 Yes Yes 0 7 0 1
R:R:F277 R:R:G224 3.01 4 Yes No 7 8 2 2
R:R:E279 R:R:S250 7.19 0 No No 4 3 1 2
L:L:?902 R:R:E279 3.87 0 Yes No 0 4 0 1
R:R:G65 R:R:Y64 1.45 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.57
Average Nodes In Shell22.00
Average Hubs In Shell6.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell19.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of Z99 in 7FD9
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:S42 S:S:W100 8.65 0 No Yes 6 3 2 1
S:S:Q46 S:S:W100 3.29 41 No Yes 3 3 2 1
S:S:R61 S:S:Y64 12.35 0 No Yes 5 4 2 1
S:S:Q63 S:S:Y64 6.76 0 No Yes 2 4 2 1
S:S:R68 S:S:Y64 11.32 2 Yes Yes 4 4 2 1
M:M:?902 S:S:Y64 6.84 0 Yes Yes 0 4 0 1
S:S:S151 S:S:W100 8.65 0 No Yes 4 3 2 1
M:M:?902 S:S:W100 7.48 0 Yes Yes 0 3 0 1
S:S:S152 S:S:S176 4.89 0 No No 9 7 1 2
M:M:?902 S:S:S152 8.76 0 Yes No 0 9 0 1
S:S:T175 S:S:V192 3.17 0 No No 8 7 1 2
S:S:D195 S:S:T175 10.12 7 No No 8 8 2 1
M:M:?902 S:S:T175 9.68 0 Yes No 0 8 0 1
S:S:N222 S:S:S176 2.98 0 No No 6 7 1 2
S:S:D195 S:S:Y223 10.34 7 No Yes 8 7 2 1
S:S:D195 S:S:F277 5.97 7 No Yes 8 7 2 2
S:S:E279 S:S:T219 5.64 0 No No 4 5 1 2
M:M:?902 S:S:N222 3.01 0 Yes No 0 6 0 1
S:S:G224 S:S:Y223 4.35 7 No Yes 8 7 2 1
S:S:F277 S:S:Y223 15.47 7 Yes Yes 7 7 2 1
M:M:?902 S:S:Y223 27.37 0 Yes Yes 0 7 0 1
S:S:F277 S:S:G224 3.01 7 Yes No 7 8 2 2
S:S:E279 S:S:S250 7.19 0 No No 4 3 1 2
M:M:?902 S:S:E279 3.87 0 Yes No 0 4 0 1
S:S:G65 S:S:Y64 1.45 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.57
Average Nodes In Shell22.00
Average Hubs In Shell6.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell19.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7MTQ C Aminoacid Metabotropic glutamate mGlu2; mGlu2 Homo sapiens LY341495 - - 3.65 2021-07-07 10.1038/s41586-021-03680-3

A 2D representation of the interactions of Z99 in 7MTQ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:N54 R:R:R57 6.03 0 No Yes 4 4 2 1
R:R:R57 R:R:R61 3.2 2 Yes Yes 4 4 1 1
L:L:?902 R:R:R57 6.2 2 Yes Yes 0 4 0 1
R:R:R61 R:R:S143 3.95 2 Yes No 4 4 1 2
R:R:R61 R:R:Y165 6.17 2 Yes Yes 4 8 1 2
R:R:E375 R:R:R61 15.12 2 Yes Yes 5 4 2 1
R:R:K377 R:R:R61 4.95 2 Yes Yes 3 4 1 1
R:R:R61 R:R:V381 3.92 2 Yes No 4 7 1 2
L:L:?902 R:R:R61 2.66 2 Yes Yes 0 4 0 1
R:R:S93 R:R:Y144 7.63 0 No No 1 3 2 1
R:R:S143 R:R:Y165 3.82 2 No Yes 4 8 2 2
L:L:?902 R:R:Y144 4.28 2 Yes No 0 3 0 1
R:R:S145 R:R:S169 4.89 0 No No 8 7 1 2
L:L:?902 R:R:S145 12.05 2 Yes No 0 8 0 1
R:R:A166 R:R:Y165 2.67 0 No Yes 5 8 2 2
R:R:V381 R:R:Y165 5.05 2 No Yes 7 8 2 2
R:R:A166 R:R:K377 4.82 0 No Yes 5 3 2 1
R:R:T168 R:R:V185 4.76 0 No No 7 7 1 2
R:R:D188 R:R:T168 8.67 0 No No 8 7 2 1
L:L:?902 R:R:T168 5.38 2 Yes No 0 7 0 1
R:R:K171 R:R:S169 7.65 2 Yes No 3 7 2 2
R:R:D215 R:R:S169 4.42 2 Yes No 5 7 1 2
R:R:D215 R:R:K171 11.06 2 Yes Yes 5 3 1 2
R:R:K171 R:R:T219 6.01 2 Yes No 3 4 2 2
R:R:F380 R:R:V185 2.62 0 Yes No 6 7 2 2
R:R:D188 R:R:Y216 3.45 0 No Yes 8 7 2 1
R:R:D215 R:R:T219 8.67 2 Yes No 5 4 1 2
L:L:?902 R:R:D215 6.93 2 Yes Yes 0 5 0 1
R:R:G217 R:R:Y216 2.9 0 No Yes 8 7 2 1
R:R:F269 R:R:Y216 5.16 2 Yes Yes 7 7 2 1
R:R:S294 R:R:Y216 6.36 2 No Yes 8 7 2 1
R:R:D295 R:R:Y216 5.75 0 No Yes 8 7 2 1
L:L:?902 R:R:Y216 17.11 2 Yes Yes 0 7 0 1
R:R:F269 R:R:S294 3.96 2 Yes No 7 8 2 2
R:R:E375 R:R:S376 7.19 2 Yes No 5 5 2 2
R:R:E375 R:R:K377 6.75 2 Yes Yes 5 3 2 1
R:R:K377 R:R:S376 6.12 2 Yes No 3 5 1 2
R:R:F380 R:R:K377 3.72 0 Yes Yes 6 3 2 1
L:L:?902 R:R:K377 4.12 2 Yes Yes 0 3 0 1
R:R:D146 R:R:Y144 2.3 0 No No 5 3 2 1
R:R:G58 R:R:R57 1.5 0 No Yes 6 4 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.34
Average Nodes In Shell29.00
Average Hubs In Shell11.00
Average Links In Shell41.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of Z99 in 7MTQ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:P39 S:S:S143 7.13 1 No Yes 5 4 2 2
S:S:P39 S:S:Y144 2.78 1 No Yes 5 3 2 1
S:S:N54 S:S:R57 4.82 0 No Yes 4 4 2 1
S:S:R57 S:S:Y144 4.12 1 Yes Yes 4 3 1 1
M:M:?901 S:S:R57 11.52 1 Yes Yes 0 4 0 1
S:S:R61 S:S:S143 2.64 1 Yes Yes 4 4 1 2
S:S:R61 S:S:Y165 4.12 1 Yes Yes 4 8 1 2
S:S:A166 S:S:R61 2.77 1 No Yes 5 4 2 1
S:S:E375 S:S:R61 10.47 1 Yes Yes 5 4 2 1
S:S:K377 S:S:R61 4.95 1 Yes Yes 3 4 2 1
S:S:R61 S:S:V381 2.62 1 Yes No 4 7 1 2
M:M:?901 S:S:R61 2.66 1 Yes Yes 0 4 0 1
S:S:S93 S:S:Y144 5.09 0 No Yes 1 3 2 1
S:S:S143 S:S:Y144 5.09 1 Yes Yes 4 3 2 1
S:S:S143 S:S:Y165 2.54 1 Yes Yes 4 8 2 2
M:M:?901 S:S:Y144 3.42 1 Yes Yes 0 3 0 1
S:S:S145 S:S:S169 4.89 1 No No 8 7 1 1
M:M:?901 S:S:S145 8.76 1 Yes No 0 8 0 1
S:S:A166 S:S:Y165 2.67 1 No Yes 5 8 2 2
S:S:V381 S:S:Y165 6.31 1 No Yes 7 8 2 2
S:S:A166 S:S:K377 3.21 1 No Yes 5 3 2 2
S:S:T168 S:S:V185 3.17 0 No Yes 7 7 1 2
S:S:D188 S:S:T168 7.23 0 No No 8 7 2 1
M:M:?901 S:S:T168 5.38 1 Yes No 0 7 0 1
S:S:K171 S:S:S169 3.06 1 No No 3 7 2 1
M:M:?901 S:S:S169 3.29 1 Yes No 0 7 0 1
S:S:D215 S:S:K171 11.06 1 No No 5 3 1 2
S:S:K171 S:S:T219 4.5 1 No No 3 4 2 2
S:S:D188 S:S:Y216 6.9 0 No Yes 8 7 2 1
S:S:D215 S:S:T219 4.34 1 No No 5 4 1 2
M:M:?901 S:S:D215 3.96 1 Yes No 0 5 0 1
S:S:G217 S:S:Y216 2.9 0 No Yes 8 7 2 1
S:S:F269 S:S:Y216 9.28 1 Yes Yes 7 7 2 1
S:S:S294 S:S:Y216 5.09 1 No Yes 8 7 2 1
S:S:D295 S:S:Y216 4.6 0 No Yes 8 7 2 1
M:M:?901 S:S:Y216 21.38 1 Yes Yes 0 7 0 1
S:S:F269 S:S:S294 10.57 1 Yes No 7 8 2 2
S:S:E375 S:S:K377 8.1 1 Yes Yes 5 3 2 2
S:S:D146 S:S:Y144 2.3 0 No Yes 5 3 2 1
S:S:G58 S:S:R57 1.5 0 No Yes 6 4 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.55
Average Nodes In Shell28.00
Average Hubs In Shell11.00
Average Links In Shell40.00
Average Links Mediated by Hubs In Shell34.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WI6 C Aminoacid Metabotropic glutamate mGlu3; mGlu3 Homo sapiens LY341495 - - 3.71 2022-03-16 10.1038/s41422-022-00623-z

A 2D representation of the interactions of Z99 in 7WI6
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:N61 R:R:R64 3.62 0 No Yes 4 5 2 1
R:R:R64 R:R:R68 5.33 14 Yes Yes 5 4 1 1
R:R:R64 R:R:Y150 9.26 14 Yes No 5 4 1 2
L:L:?1 R:R:R64 10.64 14 Yes Yes 0 5 0 1
R:R:R68 R:R:Y171 10.29 14 Yes Yes 4 6 1 2
R:R:K389 R:R:R68 7.43 14 Yes Yes 4 4 1 1
L:L:?1 R:R:R68 5.32 14 Yes Yes 0 4 0 1
R:R:S151 R:R:S173 3.26 0 No No 9 7 1 2
R:R:S151 R:R:S175 4.89 0 No No 9 7 1 2
L:L:?1 R:R:S151 5.48 14 Yes No 0 9 0 1
L:L:?1 R:R:A172 3.45 14 Yes No 0 5 0 1
R:R:D194 R:R:T174 13.01 0 No No 8 8 2 1
L:L:?1 R:R:T174 3.23 14 Yes No 0 8 0 1
R:R:D194 R:R:Y222 3.45 0 No No 8 7 2 1
R:R:F275 R:R:Y222 5.16 0 Yes No 8 7 2 1
L:L:?1 R:R:Y222 23.95 14 Yes No 0 7 0 1
R:R:F392 R:R:K389 4.96 0 No Yes 7 4 2 1
L:L:?1 R:R:K389 3.09 14 Yes Yes 0 4 0 1
R:R:K389 R:R:L325 2.82 14 Yes No 4 5 1 2
R:R:K389 R:R:S388 1.53 14 Yes No 4 5 1 2
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.88
Average Nodes In Shell18.00
Average Hubs In Shell6.00
Average Links In Shell20.00
Average Links Mediated by Hubs In Shell16.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of Z99 in 7WI6
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:N61 S:S:R64 3.62 0 No Yes 4 5 2 1
S:S:R64 S:S:R68 5.33 15 Yes Yes 5 4 1 1
S:S:R64 S:S:Y150 9.26 15 Yes No 5 4 1 2
M:M:?1 S:S:R64 10.64 15 Yes Yes 0 5 0 1
S:S:R68 S:S:Y171 10.29 15 Yes Yes 4 6 1 2
S:S:K389 S:S:R68 7.43 15 Yes Yes 4 4 1 1
M:M:?1 S:S:R68 5.32 15 Yes Yes 0 4 0 1
S:S:S151 S:S:S173 3.26 0 No No 9 7 1 2
S:S:S151 S:S:S175 4.89 0 No No 9 7 1 2
M:M:?1 S:S:S151 5.48 15 Yes No 0 9 0 1
M:M:?1 S:S:A172 3.45 15 Yes No 0 5 0 1
S:S:D194 S:S:T174 13.01 0 No No 8 8 2 1
M:M:?1 S:S:T174 3.23 15 Yes No 0 8 0 1
S:S:D194 S:S:Y222 3.45 0 No No 8 7 2 1
S:S:F275 S:S:Y222 5.16 0 Yes No 8 7 2 1
M:M:?1 S:S:Y222 23.09 15 Yes No 0 7 0 1
S:S:F392 S:S:K389 4.96 0 No Yes 7 4 2 1
M:M:?1 S:S:K389 3.09 15 Yes Yes 0 4 0 1
S:S:K389 S:S:L325 2.82 15 Yes No 4 5 1 2
S:S:K389 S:S:S388 1.53 15 Yes No 4 5 1 2
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.76
Average Nodes In Shell18.00
Average Hubs In Shell6.00
Average Links In Shell20.00
Average Links Mediated by Hubs In Shell16.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WI8 C Aminoacid Metabotropic glutamate mGlu3; mGlu3 Homo sapiens LY341495 - - 4.17 2022-03-16 10.1038/s41422-022-00623-z

A 2D representation of the interactions of Z99 in 7WI8
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F45 R:R:R68 2.14 8 Yes Yes 8 4 2 1
R:R:F45 R:R:Y171 14.44 8 Yes Yes 8 6 2 2
R:R:N61 R:R:R64 13.26 0 No No 4 5 2 1
R:R:R64 R:R:Y150 6.17 8 No Yes 5 4 1 1
L:L:?1 R:R:R64 8.86 8 Yes No 0 5 0 1
R:R:R68 R:R:Y171 5.14 8 Yes Yes 4 6 1 2
R:R:K389 R:R:R68 7.43 0 No Yes 4 4 2 1
L:L:?1 R:R:R68 4.43 8 Yes Yes 0 4 0 1
R:R:S100 R:R:Y150 2.54 0 No Yes 2 4 2 1
R:R:S149 R:R:Y150 6.36 0 No Yes 5 4 2 1
R:R:S149 R:R:Y171 5.09 0 No Yes 5 6 2 2
L:L:?1 R:R:Y150 6.84 8 Yes Yes 0 4 0 1
R:R:S151 R:R:S175 4.89 0 No No 9 7 1 2
L:L:?1 R:R:S151 5.48 8 Yes No 0 9 0 1
R:R:D194 R:R:T174 11.56 0 No No 8 8 2 1
L:L:?1 R:R:T174 4.3 8 Yes No 0 8 0 1
R:R:R277 R:R:S218 5.27 8 No No 4 5 1 2
R:R:G223 R:R:Y222 2.9 0 No Yes 7 7 2 1
R:R:F275 R:R:Y222 6.19 0 Yes Yes 8 7 2 1
R:R:R277 R:R:Y222 4.12 8 No Yes 4 7 1 1
R:R:D301 R:R:Y222 3.45 0 No Yes 8 7 2 1
L:L:?1 R:R:Y222 22.24 8 Yes Yes 0 7 0 1
L:L:?1 R:R:R277 5.32 8 Yes No 0 4 0 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub3.00
Average Interaction Strength8.21
Average Nodes In Shell20.00
Average Hubs In Shell7.00
Average Links In Shell23.00
Average Links Mediated by Hubs In Shell19.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of Z99 in 7WI8
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F45 S:S:R68 2.14 9 Yes Yes 8 4 2 1
S:S:F45 S:S:Y171 14.44 9 Yes Yes 8 6 2 2
S:S:N61 S:S:R64 9.64 0 No Yes 4 5 2 1
S:S:R64 S:S:R68 2.13 9 Yes Yes 5 4 1 1
S:S:R64 S:S:Y150 7.2 9 Yes Yes 5 4 1 1
M:M:?1 S:S:R64 11.52 9 Yes Yes 0 5 0 1
S:S:R68 S:S:Y171 5.14 9 Yes Yes 4 6 1 2
S:S:K389 S:S:R68 7.43 0 No Yes 4 4 2 1
M:M:?1 S:S:R68 3.55 9 Yes Yes 0 4 0 1
S:S:S100 S:S:Y150 2.54 0 No Yes 2 4 2 1
S:S:S149 S:S:Y150 6.36 0 No Yes 5 4 2 1
S:S:S149 S:S:Y171 5.09 0 No Yes 5 6 2 2
M:M:?1 S:S:Y150 6.84 9 Yes Yes 0 4 0 1
S:S:S151 S:S:S175 4.89 0 No No 9 7 1 2
M:M:?1 S:S:S151 5.48 9 Yes No 0 9 0 1
S:S:D194 S:S:T174 11.56 0 No No 8 8 2 1
M:M:?1 S:S:T174 4.3 9 Yes No 0 8 0 1
S:S:R277 S:S:S218 5.27 9 No No 4 5 1 2
S:S:G223 S:S:Y222 2.9 0 No Yes 7 7 2 1
S:S:F275 S:S:Y222 6.19 0 Yes Yes 8 7 2 1
S:S:R277 S:S:Y222 4.12 9 No Yes 4 7 1 1
S:S:D301 S:S:Y222 3.45 0 No Yes 8 7 2 1
M:M:?1 S:S:Y222 22.24 9 Yes Yes 0 7 0 1
M:M:?1 S:S:R277 5.32 9 Yes No 0 4 0 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.46
Average Nodes In Shell20.00
Average Hubs In Shell8.00
Average Links In Shell24.00
Average Links Mediated by Hubs In Shell21.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JCU C Aminoacid Metabotropic glutamate mGlu2; mGlu3 Homo sapiens LY341495 - - 2.8 2023-06-21 10.1038/s41422-023-00830-2

A 2D representation of the interactions of Z99 in 8JCU
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P39 R:R:S93 3.56 1 Yes No 5 1 2 2
R:R:P39 R:R:S143 7.13 1 Yes Yes 5 4 2 1
R:R:P39 R:R:Y144 4.17 1 Yes Yes 5 3 2 1
R:R:N54 R:R:R57 3.62 0 No Yes 4 4 2 1
R:R:R57 R:R:R61 5.33 1 Yes Yes 4 4 1 2
R:R:R57 R:R:Y144 5.14 1 Yes Yes 4 3 1 1
L:L:?1 R:R:R57 11.52 1 Yes Yes 0 4 0 1
R:R:R61 R:R:S143 5.27 1 Yes Yes 4 4 2 1
R:R:R61 R:R:Y165 8.23 1 Yes Yes 4 8 2 2
R:R:A166 R:R:R61 4.15 1 Yes Yes 5 4 1 2
R:R:K377 R:R:R61 7.43 1 Yes Yes 3 4 1 2
R:R:S93 R:R:Y144 7.63 1 No Yes 1 3 2 1
R:R:S143 R:R:Y165 5.09 1 Yes Yes 4 8 1 2
R:R:A166 R:R:S143 3.42 1 Yes Yes 5 4 1 1
L:L:?1 R:R:S143 4.38 1 Yes Yes 0 4 0 1
R:R:D146 R:R:Y144 3.45 0 No Yes 5 3 2 1
L:L:?1 R:R:Y144 3.42 1 Yes Yes 0 3 0 1
R:R:S145 R:R:S169 6.52 0 No No 8 7 1 2
L:L:?1 R:R:S145 14.24 1 Yes No 0 8 0 1
R:R:A166 R:R:K377 4.82 1 Yes Yes 5 3 1 1
L:L:?1 R:R:A166 3.45 1 Yes Yes 0 5 0 1
R:R:T168 R:R:V185 3.17 1 No No 7 7 1 2
R:R:D188 R:R:T168 8.67 1 Yes No 8 7 1 1
L:L:?1 R:R:T168 11.83 1 Yes No 0 7 0 1
R:R:K171 R:R:S169 9.18 0 No No 3 7 2 2
R:R:D215 R:R:K171 5.53 0 No No 5 3 1 2
R:R:F380 R:R:V185 9.18 0 Yes No 6 7 2 2
R:R:D188 R:R:Q191 6.53 1 Yes Yes 8 8 1 2
R:R:D188 R:R:Y216 6.9 1 Yes Yes 8 7 1 1
L:L:?1 R:R:D188 3.96 1 Yes Yes 0 8 0 1
R:R:Q191 R:R:Y216 5.64 1 Yes Yes 8 7 2 1
R:R:F269 R:R:Q191 5.86 1 Yes Yes 7 8 2 2
R:R:Q191 R:R:S294 5.78 1 Yes Yes 8 8 2 2
L:L:?1 R:R:D215 6.93 1 Yes No 0 5 0 1
R:R:F269 R:R:Y216 18.57 1 Yes Yes 7 7 2 1
R:R:S294 R:R:Y216 5.09 1 Yes Yes 8 7 2 1
L:L:?1 R:R:Y216 37.63 1 Yes Yes 0 7 0 1
R:R:F269 R:R:S294 7.93 1 Yes Yes 7 8 2 2
R:R:F380 R:R:K377 3.72 0 Yes Yes 6 3 2 1
L:L:?1 R:R:K377 7.2 1 Yes Yes 0 3 0 1
R:R:K377 R:R:S376 1.53 1 Yes No 3 5 1 2
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub7.00
Average Interaction Strength10.46
Average Nodes In Shell25.00
Average Hubs In Shell15.00
Average Links In Shell41.00
Average Links Mediated by Hubs In Shell37.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of Z99 in 8JCU
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:P46 S:S:S100 5.34 1 Yes No 6 2 2 2
S:S:P46 S:S:S149 7.13 1 Yes Yes 6 5 2 1
S:S:P46 S:S:Y150 5.56 1 Yes Yes 6 4 2 1
S:S:N61 S:S:R64 4.82 0 No No 4 5 2 1
S:S:R64 S:S:R68 10.66 1 No Yes 5 4 1 1
M:M:?1 S:S:R64 9.75 1 Yes No 0 5 0 1
S:S:R68 S:S:S149 3.95 1 Yes Yes 4 5 1 1
S:S:R68 S:S:Y171 4.12 1 Yes Yes 4 6 1 2
S:S:A172 S:S:R68 4.15 1 Yes Yes 5 4 1 1
S:S:E387 S:S:R68 16.28 1 Yes Yes 5 4 2 1
S:S:K389 S:S:R68 7.43 1 Yes Yes 4 4 1 1
S:S:R68 S:S:V393 3.92 1 Yes No 4 6 1 2
M:M:?1 S:S:R68 4.43 1 Yes Yes 0 4 0 1
S:S:S100 S:S:Y150 7.63 1 No Yes 2 4 2 1
S:S:S149 S:S:Y150 3.82 1 Yes Yes 5 4 1 1
S:S:S149 S:S:Y171 7.63 1 Yes Yes 5 6 1 2
S:S:A172 S:S:S149 3.42 1 Yes Yes 5 5 1 1
M:M:?1 S:S:S149 3.29 1 Yes Yes 0 5 0 1
M:M:?1 S:S:Y150 4.28 1 Yes Yes 0 4 0 1
S:S:S151 S:S:S175 6.52 0 No No 9 7 1 2
M:M:?1 S:S:S151 14.24 1 Yes No 0 9 0 1
S:S:V393 S:S:Y171 7.57 1 No Yes 6 6 2 2
S:S:A172 S:S:K389 4.82 1 Yes Yes 5 4 1 1
M:M:?1 S:S:A172 3.45 1 Yes Yes 0 5 0 1
S:S:T174 S:S:V191 3.17 1 No No 8 7 1 2
S:S:D194 S:S:T174 10.12 1 No No 8 8 1 1
M:M:?1 S:S:T174 12.91 1 Yes No 0 8 0 1
S:S:K177 S:S:S175 4.59 0 No No 4 7 2 2
S:S:D221 S:S:K177 2.77 0 No No 6 4 1 2
S:S:F392 S:S:V191 9.18 0 Yes No 7 7 2 2
S:S:D194 S:S:Y222 6.9 1 No Yes 8 7 1 1
M:M:?1 S:S:D194 4.95 1 Yes No 0 8 0 1
S:S:D221 S:S:T225 2.89 0 No No 6 4 1 2
M:M:?1 S:S:D221 3.96 1 Yes No 0 6 0 1
S:S:G223 S:S:Y222 4.35 1 No Yes 7 7 2 1
S:S:F275 S:S:Y222 19.6 1 Yes Yes 8 7 2 1
S:S:S300 S:S:Y222 3.82 1 Yes Yes 8 7 2 1
M:M:?1 S:S:Y222 26.52 1 Yes Yes 0 7 0 1
S:S:F275 S:S:G223 3.01 1 Yes No 8 7 2 2
S:S:R249 S:S:R277 14.93 1 No Yes 3 4 2 1
S:S:D279 S:S:R249 4.76 1 Yes No 1 3 2 2
S:S:F275 S:S:S300 7.93 1 Yes Yes 8 8 2 2
S:S:D279 S:S:R277 13.1 1 Yes Yes 1 4 2 1
S:S:D280 S:S:R277 13.1 1 Yes Yes 4 4 2 1
M:M:?1 S:S:R277 4.43 1 Yes Yes 0 4 0 1
S:S:D279 S:S:D280 9.31 1 Yes Yes 1 4 2 2
S:S:K389 S:S:L325 2.82 1 Yes No 4 5 1 2
S:S:E387 S:S:S388 4.31 1 Yes No 5 5 2 2
S:S:E387 S:S:K389 5.4 1 Yes Yes 5 4 2 1
S:S:K389 S:S:S388 3.06 1 Yes No 4 5 1 2
S:S:F392 S:S:K389 4.96 0 Yes Yes 7 4 2 1
M:M:?1 S:S:K389 7.2 1 Yes Yes 0 4 0 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.28
Average Nodes In Shell32.00
Average Hubs In Shell16.00
Average Links In Shell52.00
Average Links Mediated by Hubs In Shell45.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JCV C Aminoacid Metabotropic glutamate mGlu2; mGlu3 Homo sapiens LY341495 - - 3.4 2023-06-21 10.1038/s41422-023-00830-2

A 2D representation of the interactions of Z99 in 8JCV
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P39 R:R:S143 7.13 0 No Yes 5 4 2 1
R:R:P39 R:R:Y144 4.17 0 No Yes 5 3 2 1
R:R:R57 R:R:R61 5.33 2 No Yes 4 4 1 1
R:R:R57 R:R:Y144 9.26 2 No Yes 4 3 1 1
L:L:?1 R:R:R57 15.07 2 Yes No 0 4 0 1
R:R:R61 R:R:S143 3.95 2 Yes Yes 4 4 1 1
R:R:R61 R:R:Y165 7.2 2 Yes Yes 4 8 1 2
R:R:A166 R:R:R61 4.15 2 Yes Yes 5 4 1 1
R:R:E375 R:R:R61 6.98 2 No Yes 5 4 2 1
R:R:K377 R:R:R61 6.19 2 Yes Yes 3 4 1 1
R:R:I378 R:R:R61 2.51 2 Yes Yes 7 4 2 1
R:R:R61 R:R:V381 3.92 2 Yes No 4 7 1 2
L:L:?1 R:R:R61 8.86 2 Yes Yes 0 4 0 1
R:R:S93 R:R:Y144 5.09 0 No Yes 1 3 2 1
R:R:S143 R:R:Y165 8.9 2 Yes Yes 4 8 1 2
L:L:?1 R:R:S143 4.38 2 Yes Yes 0 4 0 1
R:R:D146 R:R:Y144 3.45 2 No Yes 5 3 2 1
R:R:V147 R:R:Y144 2.52 2 Yes Yes 4 3 2 1
L:L:?1 R:R:Y144 4.28 2 Yes Yes 0 3 0 1
R:R:S145 R:R:S169 4.89 2 No No 8 7 1 1
L:L:?1 R:R:S145 8.76 2 Yes No 0 8 0 1
R:R:D146 R:R:V147 4.38 2 No Yes 5 4 2 2
R:R:A166 R:R:Y165 2.67 2 Yes Yes 5 8 1 2
R:R:V381 R:R:Y165 12.62 2 No Yes 7 8 2 2
R:R:A166 R:R:K377 4.82 2 Yes Yes 5 3 1 1
L:L:?1 R:R:A166 3.45 2 Yes Yes 0 5 0 1
R:R:T168 R:R:V185 3.17 0 No Yes 7 7 1 2
R:R:D188 R:R:T168 8.67 2 No No 8 7 2 1
L:L:?1 R:R:T168 9.68 2 Yes No 0 7 0 1
L:L:?1 R:R:S169 3.29 2 Yes No 0 7 0 1
R:R:L319 R:R:V185 2.98 2 Yes Yes 4 7 2 2
R:R:F380 R:R:V185 9.18 2 Yes Yes 6 7 2 2
R:R:D188 R:R:Q191 5.22 2 No Yes 8 8 2 2
R:R:D188 R:R:Y216 9.2 2 No Yes 8 7 2 1
R:R:Q191 R:R:Y216 6.76 2 Yes Yes 8 7 2 1
R:R:Q191 R:R:S294 10.11 2 Yes Yes 8 8 2 2
R:R:D215 R:R:T219 2.89 0 No No 5 4 1 2
L:L:?1 R:R:D215 6.93 2 Yes No 0 5 0 1
R:R:S294 R:R:Y216 7.63 2 Yes Yes 8 7 2 1
R:R:G296 R:R:Y216 4.35 2 No Yes 5 7 1 1
L:L:?1 R:R:Y216 17.11 2 Yes Yes 0 7 0 1
R:R:R243 R:R:R271 5.33 0 No No 2 5 2 1
L:L:?1 R:R:R271 4.43 2 Yes No 0 5 0 1
L:L:?1 R:R:G296 2.5 2 Yes No 0 5 0 1
R:R:K377 R:R:L319 2.82 2 Yes Yes 3 4 1 2
R:R:F380 R:R:L319 4.87 2 Yes Yes 6 4 2 2
R:R:E375 R:R:I378 5.47 2 No Yes 5 7 2 2
R:R:F380 R:R:K377 4.96 2 Yes Yes 6 3 2 1
L:L:?1 R:R:K377 4.12 2 Yes Yes 0 3 0 1
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub6.00
Average Interaction Strength7.14
Average Nodes In Shell30.00
Average Hubs In Shell15.00
Average Links In Shell49.00
Average Links Mediated by Hubs In Shell45.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of Z99 in 8JCV
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:P46 S:S:S149 7.13 0 No Yes 6 5 2 1
S:S:P46 S:S:Y150 5.56 0 No Yes 6 4 2 1
S:S:N61 S:S:R64 10.85 0 No No 4 5 2 1
M:M:?1 S:S:R64 8.86 1 Yes No 0 5 0 1
S:S:R68 S:S:S149 5.27 1 Yes Yes 4 5 1 1
S:S:R68 S:S:Y171 10.29 1 Yes Yes 4 6 1 2
S:S:A172 S:S:R68 2.77 1 No Yes 5 4 2 1
S:S:E387 S:S:R68 8.14 1 Yes Yes 5 4 2 1
S:S:K389 S:S:R68 6.19 1 Yes Yes 4 4 1 1
S:S:R68 S:S:V393 3.92 1 Yes No 4 6 1 2
M:M:?1 S:S:R68 2.66 1 Yes Yes 0 4 0 1
S:S:S100 S:S:Y150 8.9 0 No Yes 2 4 2 1
S:S:S149 S:S:Y171 7.63 1 Yes Yes 5 6 1 2
M:M:?1 S:S:S149 3.29 1 Yes Yes 0 5 0 1
S:S:V153 S:S:Y150 2.52 0 No Yes 3 4 2 1
M:M:?1 S:S:Y150 3.42 1 Yes Yes 0 4 0 1
S:S:S151 S:S:S175 6.52 0 No Yes 9 7 1 2
M:M:?1 S:S:S151 13.15 1 Yes No 0 9 0 1
S:S:A172 S:S:Y171 2.67 1 No Yes 5 6 2 2
S:S:V393 S:S:Y171 7.57 1 No Yes 6 6 2 2
S:S:A172 S:S:K389 4.82 1 No Yes 5 4 2 1
S:S:T174 S:S:V191 3.17 0 No No 8 7 1 2
S:S:D194 S:S:T174 5.78 1 No No 8 8 2 1
M:M:?1 S:S:T174 8.6 1 Yes No 0 8 0 1
S:S:K177 S:S:S175 3.06 1 No Yes 4 7 2 2
S:S:D221 S:S:S175 5.89 1 Yes Yes 6 7 1 2
S:S:D221 S:S:K177 6.91 1 Yes No 6 4 1 2
S:S:F392 S:S:V191 9.18 0 Yes No 7 7 2 2
S:S:D194 S:S:Q197 3.92 1 No Yes 8 9 2 2
S:S:D194 S:S:Y222 8.05 1 No Yes 8 7 2 1
S:S:Q197 S:S:Y222 3.38 1 Yes Yes 9 7 2 1
S:S:Q197 S:S:S300 2.89 1 Yes No 9 8 2 2
S:S:R277 S:S:S218 3.95 1 Yes No 4 5 1 2
S:S:D280 S:S:S218 4.42 1 Yes No 4 5 2 2
S:S:D221 S:S:T225 4.34 1 Yes No 6 4 1 2
M:M:?1 S:S:D221 4.95 1 Yes Yes 0 6 0 1
S:S:G223 S:S:Y222 2.9 0 No Yes 7 7 2 1
S:S:R277 S:S:Y222 3.09 1 Yes Yes 4 7 1 1
S:S:S300 S:S:Y222 5.09 1 No Yes 8 7 2 1
M:M:?1 S:S:Y222 31.65 1 Yes Yes 0 7 0 1
S:S:R249 S:S:R277 3.2 0 No Yes 3 4 2 1
S:S:D279 S:S:R277 3.57 0 No Yes 1 4 2 1
S:S:D280 S:S:R277 4.76 1 Yes Yes 4 4 2 1
M:M:?1 S:S:R277 7.09 1 Yes Yes 0 4 0 1
M:M:?1 S:S:G302 2.5 1 Yes No 0 5 0 1
S:S:K389 S:S:L325 2.82 1 Yes Yes 4 5 1 2
S:S:F392 S:S:K389 6.2 0 Yes Yes 7 4 2 1
M:M:?1 S:S:K389 5.14 1 Yes Yes 0 4 0 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.30
Average Nodes In Shell34.00
Average Hubs In Shell15.00
Average Links In Shell48.00
Average Links Mediated by Hubs In Shell45.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JCW C Aminoacid Metabotropic glutamate mGlu2; mGlu3 Homo sapiens LY341495 - - 3 2023-06-21 10.1038/s41422-023-00830-2

A 2D representation of the interactions of Z99 in 8JCW
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P39 R:R:S93 3.56 2 Yes No 5 1 2 2
R:R:P39 R:R:S143 7.13 2 Yes Yes 5 4 2 1
R:R:P39 R:R:Y144 4.17 2 Yes Yes 5 3 2 1
R:R:N54 R:R:R57 4.82 0 No Yes 4 4 2 1
R:R:R57 R:R:R61 8.53 2 Yes Yes 4 4 1 1
R:R:R57 R:R:Y144 4.12 2 Yes Yes 4 3 1 1
R:R:E375 R:R:R57 5.82 2 No Yes 5 4 2 1
L:L:?1 R:R:R57 14.18 2 Yes Yes 0 4 0 1
R:R:R61 R:R:S143 3.95 2 Yes Yes 4 4 1 1
R:R:R61 R:R:Y165 7.2 2 Yes Yes 4 8 1 2
R:R:A166 R:R:R61 4.15 2 Yes Yes 5 4 1 1
R:R:E375 R:R:R61 17.45 2 No Yes 5 4 2 1
R:R:K377 R:R:R61 7.43 2 Yes Yes 3 4 1 1
R:R:R61 R:R:V381 3.92 2 Yes No 4 7 1 2
L:L:?1 R:R:R61 4.43 2 Yes Yes 0 4 0 1
R:R:S93 R:R:Y144 5.09 2 No Yes 1 3 2 1
R:R:S143 R:R:Y144 3.82 2 Yes Yes 4 3 1 1
R:R:S143 R:R:Y165 3.82 2 Yes Yes 4 8 1 2
R:R:A166 R:R:S143 3.42 2 Yes Yes 5 4 1 1
L:L:?1 R:R:S143 3.29 2 Yes Yes 0 4 0 1
R:R:D146 R:R:Y144 3.45 0 No Yes 5 3 2 1
L:L:?1 R:R:Y144 4.28 2 Yes Yes 0 3 0 1
R:R:S145 R:R:S169 6.52 0 No No 8 7 1 2
L:L:?1 R:R:S145 12.05 2 Yes No 0 8 0 1
R:R:A166 R:R:Y165 2.67 2 Yes Yes 5 8 1 2
R:R:V381 R:R:Y165 7.57 2 No Yes 7 8 2 2
R:R:A166 R:R:K377 4.82 2 Yes Yes 5 3 1 1
L:L:?1 R:R:A166 3.45 2 Yes Yes 0 5 0 1
R:R:T168 R:R:V185 3.17 2 No No 7 7 1 2
R:R:D188 R:R:T168 10.12 2 Yes No 8 7 1 1
L:L:?1 R:R:T168 12.91 2 Yes No 0 7 0 1
R:R:F380 R:R:V185 9.18 0 Yes No 6 7 2 2
R:R:D188 R:R:Q191 6.53 2 Yes Yes 8 8 1 2
R:R:D188 R:R:Y216 6.9 2 Yes Yes 8 7 1 1
L:L:?1 R:R:D188 2.97 2 Yes Yes 0 8 0 1
R:R:Q191 R:R:S294 2.89 0 Yes No 8 8 2 2
R:R:R271 R:R:Y216 5.14 2 Yes Yes 5 7 1 1
R:R:S294 R:R:Y216 3.82 0 No Yes 8 7 2 1
R:R:G296 R:R:Y216 2.9 0 No Yes 5 7 2 1
L:L:?1 R:R:Y216 41.91 2 Yes Yes 0 7 0 1
R:R:E273 R:R:R271 8.14 2 No Yes 1 5 2 1
R:R:D274 R:R:R271 5.96 2 Yes Yes 4 5 2 1
L:L:?1 R:R:R271 12.41 2 Yes Yes 0 5 0 1
R:R:D274 R:R:E273 6.5 2 Yes No 4 1 2 2
R:R:F380 R:R:K377 3.72 0 Yes Yes 6 3 2 1
L:L:?1 R:R:K377 10.29 2 Yes Yes 0 3 0 1
R:R:G214 R:R:R271 1.5 0 No Yes 6 5 2 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub9.00
Average Interaction Strength11.11
Average Nodes In Shell28.00
Average Hubs In Shell15.00
Average Links In Shell47.00
Average Links Mediated by Hubs In Shell45.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of Z99 in 8JCW
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:P46 S:S:S149 7.13 0 No Yes 6 5 2 1
S:S:P46 S:S:Y150 4.17 0 No Yes 6 4 2 1
S:S:N61 S:S:R64 6.03 0 No Yes 4 5 2 1
S:S:R64 S:S:R68 6.4 1 Yes Yes 5 4 1 1
S:S:R64 S:S:Y150 4.12 1 Yes Yes 5 4 1 1
M:M:?1 S:S:R64 12.41 1 Yes Yes 0 5 0 1
S:S:R68 S:S:S149 5.27 1 Yes Yes 4 5 1 1
S:S:R68 S:S:Y171 7.2 1 Yes Yes 4 6 1 2
S:S:A172 S:S:R68 4.15 1 Yes Yes 5 4 1 1
S:S:E387 S:S:R68 19.77 1 No Yes 5 4 2 1
S:S:K389 S:S:R68 7.43 1 Yes Yes 4 4 1 1
S:S:R68 S:S:V393 3.92 1 Yes No 4 6 1 2
M:M:?1 S:S:R68 4.43 1 Yes Yes 0 4 0 1
S:S:S100 S:S:Y150 8.9 0 No Yes 2 4 2 1
S:S:S149 S:S:Y171 6.36 1 Yes Yes 5 6 1 2
S:S:A172 S:S:S149 3.42 1 Yes Yes 5 5 1 1
M:M:?1 S:S:S149 3.29 1 Yes Yes 0 5 0 1
M:M:?1 S:S:Y150 3.42 1 Yes Yes 0 4 0 1
S:S:S151 S:S:S175 6.52 0 No No 9 7 1 2
M:M:?1 S:S:S151 14.24 1 Yes No 0 9 0 1
S:S:A172 S:S:Y171 2.67 1 Yes Yes 5 6 1 2
S:S:V393 S:S:Y171 12.62 1 No Yes 6 6 2 2
S:S:A172 S:S:K389 3.21 1 Yes Yes 5 4 1 1
M:M:?1 S:S:A172 3.45 1 Yes Yes 0 5 0 1
S:S:T174 S:S:V191 3.17 1 No No 8 7 1 2
S:S:D194 S:S:T174 10.12 1 Yes No 8 8 1 1
M:M:?1 S:S:T174 10.75 1 Yes No 0 8 0 1
S:S:F392 S:S:V191 9.18 1 Yes No 7 7 2 2
S:S:D194 S:S:Q197 5.22 1 Yes Yes 8 9 1 2
S:S:D194 S:S:Y222 8.05 1 Yes Yes 8 7 1 1
M:M:?1 S:S:D194 2.97 1 Yes Yes 0 8 0 1
S:S:F275 S:S:Q197 9.37 1 Yes Yes 8 9 2 2
S:S:Q197 S:S:S300 2.89 1 Yes Yes 9 8 2 2
S:S:R277 S:S:S218 2.64 1 Yes Yes 4 5 1 2
S:S:D280 S:S:S218 5.89 1 Yes Yes 4 5 2 2
M:M:?1 S:S:D221 6.93 1 Yes No 0 6 0 1
S:S:G223 S:S:Y222 4.35 0 No Yes 7 7 2 1
S:S:F275 S:S:Y222 14.44 1 Yes Yes 8 7 2 1
S:S:S300 S:S:Y222 3.82 1 Yes Yes 8 7 2 1
M:M:?1 S:S:Y222 30.79 1 Yes Yes 0 7 0 1
S:S:R249 S:S:R277 3.2 0 No Yes 3 4 2 1
S:S:F275 S:S:S300 5.28 1 Yes Yes 8 8 2 2
S:S:D279 S:S:R277 5.96 1 No Yes 1 4 2 1
S:S:D280 S:S:R277 4.76 1 Yes Yes 4 4 2 1
M:M:?1 S:S:R277 2.66 1 Yes Yes 0 4 0 1
S:S:D279 S:S:D280 6.65 1 No Yes 1 4 2 2
S:S:F392 S:S:K389 4.96 1 Yes Yes 7 4 2 1
M:M:?1 S:S:K389 4.12 1 Yes Yes 0 4 0 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub9.00
Average Interaction Strength8.29
Average Nodes In Shell30.00
Average Hubs In Shell17.00
Average Links In Shell48.00
Average Links Mediated by Hubs In Shell46.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JCX C Aminoacid Metabotropic glutamate mGlu2; mGlu3 Homo sapiens LY341495 - - 3 2023-06-21 10.1038/s41422-023-00830-2

A 2D representation of the interactions of Z99 in 8JCX
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P39 R:R:S143 7.13 2 No Yes 5 4 2 1
R:R:P39 R:R:Y144 8.34 2 No Yes 5 3 2 1
R:R:N54 R:R:R57 4.82 0 No Yes 4 4 2 1
R:R:R57 R:R:R61 10.66 2 Yes Yes 4 4 1 1
R:R:R57 R:R:Y144 4.12 2 Yes Yes 4 3 1 1
R:R:E375 R:R:R57 3.49 2 Yes Yes 5 4 2 1
L:L:?1 R:R:R57 9.75 2 Yes Yes 0 4 0 1
R:R:R61 R:R:S143 3.95 2 Yes Yes 4 4 1 1
R:R:R61 R:R:Y165 7.2 2 Yes Yes 4 8 1 2
R:R:A166 R:R:R61 4.15 2 Yes Yes 5 4 1 1
R:R:E375 R:R:R61 8.14 2 Yes Yes 5 4 2 1
R:R:K377 R:R:R61 4.95 2 Yes Yes 3 4 1 1
R:R:R61 R:R:V381 3.92 2 Yes No 4 7 1 2
L:L:?1 R:R:R61 4.43 2 Yes Yes 0 4 0 1
R:R:S93 R:R:Y144 6.36 0 No Yes 1 3 2 1
R:R:S143 R:R:Y144 6.36 2 Yes Yes 4 3 1 1
R:R:S143 R:R:Y165 5.09 2 Yes Yes 4 8 1 2
R:R:A166 R:R:S143 3.42 2 Yes Yes 5 4 1 1
L:L:?1 R:R:S143 3.29 2 Yes Yes 0 4 0 1
R:R:D146 R:R:Y144 3.45 0 No Yes 5 3 2 1
L:L:?1 R:R:Y144 5.13 2 Yes Yes 0 3 0 1
R:R:S145 R:R:S169 6.52 2 No No 8 7 1 1
L:L:?1 R:R:S145 12.05 2 Yes No 0 8 0 1
R:R:V381 R:R:Y165 7.57 2 No Yes 7 8 2 2
R:R:A166 R:R:K377 4.82 2 Yes Yes 5 3 1 1
L:L:?1 R:R:A166 3.45 2 Yes Yes 0 5 0 1
R:R:T168 R:R:V185 3.17 2 No No 7 7 1 2
R:R:D188 R:R:T168 10.12 2 Yes No 8 7 1 1
L:L:?1 R:R:T168 11.83 2 Yes No 0 7 0 1
L:L:?1 R:R:S169 5.48 2 Yes No 0 7 0 1
R:R:D215 R:R:K171 4.15 0 No No 5 3 1 2
R:R:F380 R:R:V185 9.18 2 Yes No 6 7 2 2
R:R:D188 R:R:Q191 6.53 2 Yes Yes 8 8 1 2
R:R:D188 R:R:Y216 6.9 2 Yes Yes 8 7 1 1
L:L:?1 R:R:D188 3.96 2 Yes Yes 0 8 0 1
R:R:Q191 R:R:Y216 5.64 2 Yes Yes 8 7 2 1
R:R:Q191 R:R:S294 7.22 2 Yes Yes 8 8 2 2
L:L:?1 R:R:D215 8.91 2 Yes No 0 5 0 1
R:R:S294 R:R:Y216 7.63 2 Yes Yes 8 7 2 1
R:R:G296 R:R:Y216 4.35 0 No Yes 5 7 2 1
L:L:?1 R:R:Y216 31.65 2 Yes Yes 0 7 0 1
R:R:R243 R:R:R271 5.33 0 No Yes 2 5 2 1
R:R:E273 R:R:R271 15.12 2 No Yes 1 5 2 1
R:R:D274 R:R:R271 16.68 2 Yes Yes 4 5 2 1
L:L:?1 R:R:R271 3.55 2 Yes Yes 0 5 0 1
R:R:D274 R:R:E273 6.5 2 Yes No 4 1 2 2
R:R:F380 R:R:K377 4.96 2 Yes Yes 6 3 2 1
L:L:?1 R:R:K377 7.2 2 Yes Yes 0 3 0 1
R:R:V147 R:R:Y144 2.52 0 No Yes 4 3 2 1
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub9.00
Average Interaction Strength8.51
Average Nodes In Shell31.00
Average Hubs In Shell16.00
Average Links In Shell49.00
Average Links Mediated by Hubs In Shell46.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of Z99 in 8JCX
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:P46 S:S:S149 7.13 1 Yes Yes 6 5 2 1
S:S:P46 S:S:Y150 4.17 1 Yes Yes 6 4 2 2
S:S:N61 S:S:R64 7.23 0 No Yes 4 5 2 1
S:S:R64 S:S:R68 9.6 1 Yes Yes 5 4 1 1
S:S:R64 S:S:Y150 5.14 1 Yes Yes 5 4 1 2
M:M:?1 S:S:R64 10.64 1 Yes Yes 0 5 0 1
S:S:R68 S:S:S149 5.27 1 Yes Yes 4 5 1 1
S:S:R68 S:S:Y171 7.2 1 Yes Yes 4 6 1 2
S:S:A172 S:S:R68 4.15 1 Yes Yes 5 4 1 1
S:S:E387 S:S:R68 4.65 0 Yes Yes 5 4 2 1
S:S:K389 S:S:R68 7.43 1 Yes Yes 4 4 1 1
S:S:R68 S:S:V393 3.92 1 Yes No 4 6 1 2
M:M:?1 S:S:R68 3.55 1 Yes Yes 0 4 0 1
S:S:S149 S:S:Y150 3.82 1 Yes Yes 5 4 1 2
S:S:S149 S:S:Y171 5.09 1 Yes Yes 5 6 1 2
S:S:A172 S:S:S149 3.42 1 Yes Yes 5 5 1 1
M:M:?1 S:S:S149 3.29 1 Yes Yes 0 5 0 1
S:S:S151 S:S:S175 6.52 0 No No 9 7 1 2
M:M:?1 S:S:S151 12.05 1 Yes No 0 9 0 1
S:S:V393 S:S:Y171 7.57 1 No Yes 6 6 2 2
S:S:A172 S:S:K389 4.82 1 Yes Yes 5 4 1 1
M:M:?1 S:S:A172 3.45 1 Yes Yes 0 5 0 1
S:S:T174 S:S:V191 3.17 1 No No 8 7 1 2
S:S:D194 S:S:T174 13.01 1 Yes No 8 8 1 1
M:M:?1 S:S:T174 15.06 1 Yes No 0 8 0 1
S:S:F392 S:S:V191 9.18 1 Yes No 7 7 2 2
S:S:D194 S:S:Q197 6.53 1 Yes Yes 8 9 1 2
S:S:D194 S:S:Y222 6.9 1 Yes Yes 8 7 1 1
M:M:?1 S:S:D194 4.95 1 Yes Yes 0 8 0 1
S:S:Q197 S:S:Y222 4.51 1 Yes Yes 9 7 2 1
S:S:F275 S:S:Q197 8.2 1 Yes Yes 8 9 2 2
S:S:Q197 S:S:S300 4.33 1 Yes No 9 8 2 2
S:S:G223 S:S:Y222 4.35 1 No Yes 7 7 2 1
S:S:F275 S:S:Y222 27.85 1 Yes Yes 8 7 2 1
S:S:S300 S:S:Y222 3.82 1 No Yes 8 7 2 1
M:M:?1 S:S:Y222 25.66 1 Yes Yes 0 7 0 1
S:S:F275 S:S:G223 3.01 1 Yes No 8 7 2 2
S:S:F275 S:S:S300 9.25 1 Yes No 8 8 2 2
S:S:D279 S:S:R277 9.53 1 No No 1 4 2 1
S:S:D280 S:S:R277 7.15 1 Yes No 4 4 2 1
M:M:?1 S:S:R277 7.98 1 Yes No 0 4 0 1
S:S:D279 S:S:D280 9.31 1 No Yes 1 4 2 2
S:S:F392 S:S:K389 6.2 1 Yes Yes 7 4 2 1
M:M:?1 S:S:K389 8.23 1 Yes Yes 0 4 0 1
M:M:?1 S:S:G302 2.5 1 Yes No 0 5 0 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.85
Average Nodes In Shell27.00
Average Hubs In Shell16.00
Average Links In Shell45.00
Average Links Mediated by Hubs In Shell42.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JCY C Aminoacid Metabotropic glutamate mGlu2; mGlu3 Homo sapiens LY341495 - - 2.9 2023-06-21 10.1038/s41422-023-00830-2

A 2D representation of the interactions of Z99 in 8JCY
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P39 R:R:S143 7.13 1 No Yes 5 4 2 1
R:R:P39 R:R:Y144 5.56 1 No Yes 5 3 2 2
R:R:R57 R:R:R61 11.73 1 No Yes 4 4 1 1
R:R:R57 R:R:Y144 4.12 1 No Yes 4 3 1 2
L:L:?1 R:R:R57 11.52 1 Yes No 0 4 0 1
R:R:R61 R:R:S143 5.27 1 Yes Yes 4 4 1 1
R:R:R61 R:R:Y165 7.2 1 Yes Yes 4 8 1 2
R:R:A166 R:R:R61 4.15 1 Yes Yes 5 4 1 1
R:R:E375 R:R:R61 8.14 1 Yes Yes 5 4 2 1
R:R:K377 R:R:R61 8.66 1 Yes Yes 3 4 1 1
R:R:R61 R:R:V381 3.92 1 Yes No 4 7 1 2
L:L:?1 R:R:R61 4.43 1 Yes Yes 0 4 0 1
R:R:S143 R:R:Y165 5.09 1 Yes Yes 4 8 1 2
R:R:A166 R:R:S143 3.42 1 Yes Yes 5 4 1 1
L:L:?1 R:R:S143 3.29 1 Yes Yes 0 4 0 1
R:R:S145 R:R:S169 6.52 0 No No 8 7 1 2
L:L:?1 R:R:S145 12.05 1 Yes No 0 8 0 1
R:R:A166 R:R:Y165 2.67 1 Yes Yes 5 8 1 2
R:R:V381 R:R:Y165 8.83 1 No Yes 7 8 2 2
R:R:A166 R:R:K377 4.82 1 Yes Yes 5 3 1 1
L:L:?1 R:R:A166 3.45 1 Yes Yes 0 5 0 1
R:R:T168 R:R:V185 3.17 0 No Yes 7 7 1 2
R:R:D188 R:R:T168 7.23 1 Yes No 8 7 2 1
L:L:?1 R:R:T168 12.91 1 Yes No 0 7 0 1
R:R:K377 R:R:V185 3.04 1 Yes Yes 3 7 1 2
R:R:F380 R:R:V185 10.49 1 Yes Yes 6 7 2 2
R:R:D188 R:R:Y216 3.45 1 Yes Yes 8 7 2 1
R:R:D188 R:R:F269 3.58 1 Yes Yes 8 7 2 2
R:R:F269 R:R:Y216 16.5 1 Yes Yes 7 7 2 1
R:R:R271 R:R:Y216 5.14 1 No Yes 5 7 1 1
L:L:?1 R:R:Y216 36.78 1 Yes Yes 0 7 0 1
R:R:E273 R:R:R271 6.98 0 Yes No 1 5 2 1
L:L:?1 R:R:R271 12.41 1 Yes No 0 5 0 1
R:R:E375 R:R:K377 4.05 1 Yes Yes 5 3 2 1
R:R:F380 R:R:K377 4.96 1 Yes Yes 6 3 2 1
L:L:?1 R:R:K377 4.12 1 Yes Yes 0 3 0 1
R:R:G296 R:R:Y216 1.45 0 No Yes 5 7 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub5.00
Average Interaction Strength11.22
Average Nodes In Shell22.00
Average Hubs In Shell14.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of Z99 in 8JCY
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:N61 S:S:R64 6.03 0 No No 4 5 2 1
S:S:R64 S:S:R68 11.73 2 No Yes 5 4 1 1
M:M:?1 S:S:R64 10.64 2 Yes No 0 5 0 1
S:S:R68 S:S:S149 3.95 2 Yes Yes 4 5 1 2
S:S:R68 S:S:Y171 6.17 2 Yes Yes 4 6 1 2
S:S:A172 S:S:R68 4.15 2 Yes Yes 5 4 1 1
S:S:E387 S:S:R68 13.96 2 Yes Yes 5 4 2 1
S:S:K389 S:S:R68 7.43 2 Yes Yes 4 4 2 1
S:S:R68 S:S:V393 3.92 2 Yes No 4 6 1 2
M:M:?1 S:S:R68 2.66 2 Yes Yes 0 4 0 1
S:S:S149 S:S:Y171 6.36 2 Yes Yes 5 6 2 2
S:S:A172 S:S:S149 3.42 2 Yes Yes 5 5 1 2
S:S:S151 S:S:S175 6.52 0 No No 9 7 1 2
M:M:?1 S:S:S151 14.24 2 Yes No 0 9 0 1
S:S:A172 S:S:Y171 2.67 2 Yes Yes 5 6 1 2
S:S:V393 S:S:Y171 8.83 2 No Yes 6 6 2 2
S:S:A172 S:S:K389 3.21 2 Yes Yes 5 4 1 2
M:M:?1 S:S:A172 3.45 2 Yes Yes 0 5 0 1
S:S:T174 S:S:V191 3.17 2 No No 8 7 1 2
S:S:D194 S:S:T174 11.56 2 No No 8 8 1 1
M:M:?1 S:S:T174 12.91 2 Yes No 0 8 0 1
S:S:D194 S:S:Y222 10.34 2 No Yes 8 7 1 1
M:M:?1 S:S:D194 5.94 2 Yes No 0 8 0 1
S:S:G223 S:S:Y222 4.35 0 No Yes 7 7 2 1
S:S:S300 S:S:Y222 5.09 0 No Yes 8 7 2 1
M:M:?1 S:S:Y222 26.52 2 Yes Yes 0 7 0 1
S:S:E387 S:S:K389 6.75 2 Yes Yes 5 4 2 2
M:M:?1 S:S:G302 2.5 2 Yes No 0 5 0 1
M:M:?1 S:S:D221 0.99 2 Yes No 0 6 0 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub3.00
Average Interaction Strength8.87
Average Nodes In Shell20.00
Average Hubs In Shell8.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell25.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JCZ C Aminoacid Metabotropic glutamate mGlu2; mGlu3 Homo sapiens LY341495 - - 3 2023-06-21 10.1038/s41422-023-00830-2

A 2D representation of the interactions of Z99 in 8JCZ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:N54 R:R:R57 7.23 0 No Yes 4 4 2 1
R:R:R57 R:R:R61 6.4 1 Yes Yes 4 4 1 1
R:R:R57 R:R:Y144 4.12 1 Yes Yes 4 3 1 2
L:L:?1 R:R:R57 12.41 1 Yes Yes 0 4 0 1
R:R:R61 R:R:S143 5.27 1 Yes No 4 4 1 2
R:R:R61 R:R:Y165 8.23 1 Yes Yes 4 8 1 2
R:R:A166 R:R:R61 4.15 1 No Yes 5 4 1 1
R:R:E375 R:R:R61 13.96 1 Yes Yes 5 4 2 1
R:R:K377 R:R:R61 6.19 1 Yes Yes 3 4 1 1
R:R:R61 R:R:V381 3.92 1 Yes No 4 7 1 2
L:L:?1 R:R:R61 4.43 1 Yes Yes 0 4 0 1
R:R:S143 R:R:Y165 10.17 1 No Yes 4 8 2 2
R:R:S145 R:R:S169 6.52 0 No No 8 7 1 2
L:L:?1 R:R:S145 12.05 1 Yes No 0 8 0 1
R:R:V381 R:R:Y165 8.83 1 No Yes 7 8 2 2
R:R:A166 R:R:K377 4.82 1 No Yes 5 3 1 1
L:L:?1 R:R:A166 3.45 1 Yes No 0 5 0 1
R:R:T168 R:R:V185 3.17 0 No No 7 7 1 2
R:R:D188 R:R:T168 8.67 1 No No 8 7 2 1
L:L:?1 R:R:T168 11.83 1 Yes No 0 7 0 1
R:R:K171 R:R:S169 6.12 1 No No 3 7 2 2
R:R:D215 R:R:S169 4.42 1 Yes No 5 7 1 2
R:R:D215 R:R:K171 4.15 1 Yes No 5 3 1 2
R:R:K377 R:R:V185 4.55 1 Yes No 3 7 1 2
R:R:F380 R:R:V185 9.18 1 Yes No 6 7 2 2
R:R:D188 R:R:Q191 3.92 1 No Yes 8 8 2 2
R:R:D188 R:R:Y216 6.9 1 No Yes 8 7 2 1
R:R:Q191 R:R:Y216 6.76 1 Yes Yes 8 7 2 1
R:R:Q191 R:R:S294 5.78 1 Yes No 8 8 2 2
R:R:D215 R:R:T219 10.12 1 Yes No 5 4 1 2
L:L:?1 R:R:D215 6.93 1 Yes Yes 0 5 0 1
R:R:S294 R:R:Y216 6.36 1 No Yes 8 7 2 1
R:R:G296 R:R:Y216 4.35 0 No Yes 5 7 2 1
L:L:?1 R:R:Y216 27.37 1 Yes Yes 0 7 0 1
R:R:R243 R:R:R271 4.26 11 No No 2 5 2 1
L:L:?1 R:R:R271 4.43 1 Yes No 0 5 0 1
R:R:E375 R:R:K377 5.4 1 Yes Yes 5 3 2 1
R:R:F380 R:R:K377 3.72 1 Yes Yes 6 3 2 1
L:L:?1 R:R:K377 7.2 1 Yes Yes 0 3 0 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub5.00
Average Interaction Strength10.01
Average Nodes In Shell26.00
Average Hubs In Shell11.00
Average Links In Shell39.00
Average Links Mediated by Hubs In Shell34.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of Z99 in 8JCZ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:P46 S:S:S149 7.13 0 No Yes 6 5 2 1
S:S:P46 S:S:Y150 5.56 0 No No 6 4 2 2
S:S:R64 S:S:R68 11.73 0 No Yes 5 4 1 2
S:S:R64 S:S:Y150 3.09 0 No No 5 4 1 2
M:M:?1 S:S:R64 10.64 1 Yes No 0 5 0 1
S:S:R68 S:S:S149 3.95 1 Yes Yes 4 5 2 1
S:S:R68 S:S:Y171 7.2 1 Yes Yes 4 6 2 2
S:S:A172 S:S:R68 4.15 1 Yes Yes 5 4 1 2
S:S:E387 S:S:R68 9.3 1 Yes Yes 5 4 2 2
S:S:K389 S:S:R68 6.19 1 Yes Yes 4 4 1 2
S:S:S149 S:S:Y171 7.63 1 Yes Yes 5 6 1 2
S:S:A172 S:S:S149 3.42 1 Yes Yes 5 5 1 1
M:M:?1 S:S:S149 3.29 1 Yes Yes 0 5 0 1
S:S:S151 S:S:S175 6.52 0 No No 9 7 1 2
M:M:?1 S:S:S151 12.05 1 Yes No 0 9 0 1
S:S:A172 S:S:K389 4.82 1 Yes Yes 5 4 1 1
M:M:?1 S:S:A172 3.45 1 Yes Yes 0 5 0 1
S:S:T174 S:S:V191 3.17 1 No No 8 7 1 2
S:S:D194 S:S:T174 8.67 1 No No 8 8 1 1
M:M:?1 S:S:T174 12.91 1 Yes No 0 8 0 1
S:S:D221 S:S:S175 4.42 0 No No 6 7 1 2
S:S:F392 S:S:V191 9.18 1 Yes No 7 7 2 2
S:S:D194 S:S:Y222 8.05 1 No Yes 8 7 1 1
M:M:?1 S:S:D194 3.96 1 Yes No 0 8 0 1
M:M:?1 S:S:D221 6.93 1 Yes No 0 6 0 1
S:S:S300 S:S:Y222 6.36 0 No Yes 8 7 2 1
S:S:G302 S:S:Y222 2.9 0 No Yes 5 7 2 1
M:M:?1 S:S:Y222 26.52 1 Yes Yes 0 7 0 1
S:S:D280 S:S:R277 3.57 2 Yes No 4 4 2 1
M:M:?1 S:S:R277 9.75 1 Yes No 0 4 0 1
S:S:E387 S:S:S388 2.87 1 Yes No 5 5 2 2
S:S:E387 S:S:K389 4.05 1 Yes Yes 5 4 2 1
S:S:K389 S:S:S388 3.06 1 Yes No 4 5 1 2
S:S:F392 S:S:K389 3.72 1 Yes Yes 7 4 2 1
M:M:?1 S:S:K389 6.17 1 Yes Yes 0 4 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.57
Average Nodes In Shell23.00
Average Hubs In Shell10.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links9.40
Average Number Of Links With An Hub5.30
Average Interaction Strength8.85
Average Nodes In Shell25.25
Average Hubs In Shell11.45
Average Links In Shell36.85
Average Links Mediated by Hubs In Shell32.75

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)