Orange: nodes, hubs and links specific of s1p1_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of s1p1_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner s1p1_on_gp Avg Int. Strength s1p1_off Avg Int. Strength s1p1_on_gp Num Of Links s1p1_off Num Of Links ConSurf
1G.HN.11 s1p1_on_gp3.1550402
2G.S1.02 s1p1_on_gp5.764640405
3G.H1.01 s1p1_on_gp5.15250409
4G.S2.05 s1p1_on_gp5.106430403
5G.S2.08 s1p1_on_gp7.21750405
6G.S3.03 s1p1_on_gp8.055710407
7G.S3.04 s1p1_on_gp7.999290406
8G.S3.05 s1p1_on_gp3.431430507
9G.S3.06 s1p1_on_gp7.344290605
10G.S3.07 s1p1_on_gp3.797860409
11G.s3h2.03 s1p1_on_gp4.335710409
12G.H2.04 s1p1_on_gp3.631430409
13G.H2.06 s1p1_on_gp4.962860509
14G.H2.07 s1p1_on_gp4.364080709
15G.h2s4.01 s1p1_on_gp5.1860509
16G.s4h3.04 s1p1_on_gp6.848780708
17G.s4h3.05 s1p1_on_gp9.768570409
18G.H3.01 s1p1_on_gp6.575710409
19G.H3.09 s1p1_on_gp5.130950609
20G.H3.17 s1p1_on_gp7.655710505
21G.H3.18 s1p1_on_gp5.20409
22G.S5.03 s1p1_on_gp3.523430508
23G.S5.04 s1p1_on_gp3.115710409
24G.S5.05 s1p1_on_gp3.532140609
25G.S5.07 s1p1_on_gp3.610360409
26G.HG.04 s1p1_on_gp6.228860509
27G.HG.07 s1p1_on_gp4.639140509
28G.hgh4.01 s1p1_on_gp4.477140406
29G.hgh4.02 s1p1_on_gp6.785950607
30G.hgh4.05 s1p1_on_gp7.844640407
31G.H4.03 s1p1_on_gp5.9250604
32G.H4.05 s1p1_on_gp4.111430404
33G.H4.10 s1p1_on_gp9.592140406
34G.H4.12 s1p1_on_gp7.016070405
35G.H4.15 s1p1_on_gp4.691430508
36G.h4s6.02 s1p1_on_gp5.090360408
37G.h4s6.11 s1p1_on_gp4.998210407
38G.S6.02 s1p1_on_gp5.0550807
39G.S6.05 s1p1_on_gp4.586430404
40G.s6h5.01 s1p1_on_gp4.856430409
41G.s6h5.02 s1p1_on_gp2.356790407
42G.H5.03 s1p1_on_gp5.024570508
43G.H5.08 s1p1_on_gp5.838570508
44G.H5.13 s1p1_on_gp5.72250408
45G.H5.17 s1p1_on_gp4.589640405
46G.H5.20 s1p1_on_gp3.543570409
47G.H5.25 s1p1_on_gp4.75250407
48b.1x1 s1p1_on_gp2.872290504
49b.h2x5 s1p1_on_gp3.721430405
50b.lhb1x3 s1p1_on_gp2.947860402
51b.lhb1x6 s1p1_on_gp3.252860403
52b.lhb1x11 s1p1_on_gp3.452860404
53b.b1x3 s1p1_on_gp5.356430407
54b.b1x6 s1p1_on_gp5.688570509
55b.l1x3 s1p1_on_gp7.42310609
56b.b2x1 s1p1_on_gp7.948290508
57b.b2x5 s1p1_on_gp6.926570507
58b.b3x3 s1p1_on_gp3.770360408
59b.l3x2 s1p1_on_gp4.025430509
60b.b4x3 s1p1_on_gp3.466860507
61b.b4x6 s1p1_on_gp8.990710609
62b.b5x2 s1p1_on_gp5.643930407
63b.b5x3 s1p1_on_gp5.769520609
64b.b5x5 s1p1_on_gp3.946790405
65b.b5x7 s1p1_on_gp5.74750407
66b.l5x1 s1p1_on_gp3.820290508
67b.l5x5 s1p1_on_gp7.133570609
68b.b6x5 s1p1_on_gp4.078930406
69b.l6x5 s1p1_on_gp5.710710404
70b.b7x1 s1p1_on_gp5.825430504
71b.l7x2 s1p1_on_gp3.357860409
72b.b8x4 s1p1_on_gp5.2740506
73b.l8x5 s1p1_on_gp3.073430503
74b.l9x3 s1p1_on_gp6.954050609
75b.l9x6 s1p1_on_gp4.110790908
76b.b10x5 s1p1_on_gp3.853810609
77b.l10x1 s1p1_on_gp3.122140403
78b.b11x4 s1p1_on_gp5.165430509
79b.l11x2 s1p1_on_gp6.156860509
80b.b12x6 s1p1_on_gp8.020708
81b.b12x7 s1p1_on_gp5.218210409
82b.b13x7 s1p1_on_gp7.140507
83b.l13x3 s1p1_on_gp7.578570609
84b.l13x6 s1p1_on_gp3.799640409
85b.b14x3 s1p1_on_gp3.699640405
86b.b15x1 s1p1_on_gp6.861070409
87b.b15x2 s1p1_on_gp6.183930406
88b.l15x2 s1p1_on_gp4.146290509
89b.b16x4 s1p1_on_gp9.920406
90b.b16x5 s1p1_on_gp4.099710505
91b.b16x6 s1p1_on_gp8.458090608
92b.b17x4 s1p1_on_gp5.002860405
93b.b17x5 s1p1_on_gp5.7350407
94b.b17x7 s1p1_on_gp6.984290408
95b.l17x3 s1p1_on_gp7.105510709
96b.l17x6 s1p1_on_gp5.689710509
97b.b18x3 s1p1_on_gp4.466070408
98b.l18x1 s1p1_on_gp6.412650706
99b.l18x2 s1p1_on_gp5.815360407
100b.b19x2 s1p1_on_gp5.833330606
101b.b19x4 s1p1_on_gp6.350710408
102b.l19x2 s1p1_on_gp5.931430409
103b.b20x4 s1p1_on_gp8.863430508
104b.b20x6 s1p1_on_gp5.681670606
105b.b20x7 s1p1_on_gp4.09250409
106b.l20x2 s1p1_on_gp6.946430409
107b.b21x1 s1p1_on_gp7.755710507
108b.b21x2 s1p1_on_gp4.573210406
109b.b21x5 s1p1_on_gp5.492140404
110b.b21x7 s1p1_on_gp5.049290605
111b.l21x7 s1p1_on_gp3.993570405
112b.b22x5 s1p1_on_gp5.10690607
113b.l22x5 s1p1_on_gp5.687430509
114b.b23x6 s1p1_on_gp6.429180707
115b.l23x1 s1p1_on_gp7.5750406
116b.l24x3 s1p1_on_gp5.124290405
117b.b25x7 s1p1_on_gp5.700360407
118b.l25x3 s1p1_on_gp7.973140509
119b.l27x1 s1p1_on_gp9.144050609
120b.l27x2 s1p1_on_gp7.136070409
121b.b28x4 s1p1_on_gp6.438210406
122b.b28x6 s1p1_on_gp7.044570509
123b.b28x7 s1p1_on_gp4.885710509
124g.h1x1 s1p1_on_gp2.599430502
125g.h1x5 s1p1_on_gp2.079140506
126g.h1x10 s1p1_on_gp3.142140409
127g.h1x11 s1p1_on_gp2.570860509
128g.l1x2 s1p1_on_gp3.826430402
129g.l1x4 s1p1_on_gp6.875360408
130g.h2x11 s1p1_on_gp7.796430406
131g.ctx3 s1p1_on_gp6.377860609
132g.ctx6 s1p1_on_gp4.139430506
133g.ctx16 s1p1_on_gp4.624820808
1341x39 s1p1_on_gp4.492383.22626
1351x40 s1p1_on_gp2.178214.345423
1362x39 s1p1_on_gp4.313937.55438
1372x40 s1p1_on_gp10.267410.2633539
1382x46 s1p1_on_gp4.023435.75529
1392x47 s1p1_on_gp2.206073.32429
1402x61 s1p1_on_gp5.256438.845425
141E1x501 s1p1_on_gp2.748865.325525
1423x33 s1p1_on_gp8.1413.51435
1433x44 s1p1_on_gp4.284294.28417
1443x46 s1p1_on_gp4.424294.515428
1453x49 s1p1_on_gp6.552867.21667439
1463x51 s1p1_on_gp5.256435.19333438
1474x42 s1p1_on_gp4.833933.65417
1484x60 s1p1_on_gp7.0732111.13425
149E2.W182 s1p1_on_gp4.203939.01667435
150E2.L195 s1p1_on_gp4.798577.3533
1515x48 s1p1_on_gp1.491433.89414
1525x62 s1p1_on_gp6.218215.905426
1536x28 s1p1_on_gp0.9150405
1546x33 s1p1_on_gp3.722865.5438
1556x59 s1p1_on_gp3.80754.01333434
1567x45 s1p1_on_gp6.785717.85333439
1577x53 s1p1_on_gp4.368215.27333439
1588x50 s1p1_on_gp6.456436.51333438
159Lig Shared6.7527610.58215100
160NT.H28 Shared3.58515.535748
161NT.Y29 Shared5.026539.73833767
1621x50 Shared4.413434.9075549
163I1x50 Shared9.0991412.725548
1642x42 Shared5.6986.1175548
1652x50 Shared5.095246.4075649
1662x57 Shared5.787769.458756
1673x25 Shared6.6373510.404759
1683x26 Shared5.5926.948556
1693x28 Shared5.704767.872656
1703x29 Shared7.84210.305545
1713x50 Shared5.564766.2125649
172E2.Y198 Shared4.662328.22286874
1735x39 Shared6.404299.855667
1745x58 Shared4.212145.666459
1756x44 Shared4.694299.2775449
1766x48 Shared6.2810.0967768
1776x52 Shared4.745715.5575446
1786x58 Shared4.008578.155644
1797x31 Shared4.37256.8475443
180NT.I24 s1p1_off3.060715.116254
181NT.L35 s1p1_off1.684.32240
1822x60 s1p1_off7.585718.545345
1833x37 s1p1_off4.152145.02246
1844x50 s1p1_off4.60195.19167369
185E2.I185 s1p1_off4.681436.7025243
1865x47 s1p1_off8.098576.3925347
1876x41 s1p1_off4.351434.345247
1887x50 s1p1_off3.517146.1775349
1898x47 s1p1_off6.010956.952358
   
Orange: nodes, hubs and links specific of s1p1_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of s1p1_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner s1p1_on_gp Recurrence s1p1_off Recurrence s1p1_on_gp Hub1? s1p1_off Hub1? s1p1_on_gp Hub2? s1p1_off Hub2? ConSurf1 ConSurf2
1b.b28x5 g.ctx16 s1p1_on_gp18.26350NoNoYesNo58
2b.b1x6 b.b28x5 s1p1_on_gp17.67730YesNoNoNo95
3b.b1x6 b.b4x6 s1p1_on_gp14.95520YesNoYesNo99
4b.b28x7 g.ctx16 s1p1_on_gp28.15710YesNoYesNo98
5b.b28x7 b.lhb1x11 s1p1_on_gp36.19220YesNoYesNo94
6b.b25x7 b.lhb1x11 s1p1_on_gp32.23010YesNoYesNo74
7b.b25x7 b.b28x6 s1p1_on_gp46.41930YesNoYesNo79
8b.b27x3 b.b28x6 s1p1_on_gp27.57850NoNoYesNo89
9b.b26x3 b.b27x3 s1p1_on_gp68.10290NoNoNoNo68
10b.b22x2 b.b26x3 s1p1_on_gp67.76460NoNoNoNo86
11b.b22x1 b.b22x2 s1p1_on_gp67.71110NoNoNoNo88
12b.b22x1 b.l23x1 s1p1_on_gp67.6720NoNoYesNo86
13b.l23x1 b.l25x6 s1p1_on_gp51.25060YesNoNoNo68
14b.l25x6 b.l27x1 s1p1_on_gp32.21220NoNoYesNo89
15b.b2x1 b.l27x1 s1p1_on_gp31.11880YesNoYesNo89
16b.b2x1 b.l3x1 s1p1_on_gp31.22080YesNoNoNo89
17b.l3x1 b.l5x5 s1p1_on_gp31.15110NoNoYesNo99
18b.b27x3 b.l25x3 s1p1_on_gp80.11480NoNoYesNo89
19b.l25x3 b.l27x2 s1p1_on_gp99.77020YesNoYesNo99
20b.l25x4 b.l27x2 s1p1_on_gp1000NoNoYesNo59
21I1x48 b.l25x4 s1p1_on_gp99.9760NoNoNoNo65
22I1x48 I1x51 s1p1_on_gp99.95770NoNoNoNo67
232x41 I1x51 s1p1_on_gp99.93652.64412NoNoNoNo47
242x41 4x42 s1p1_on_gp99.91580NoNoYesNo47
252x42 4x42 s1p1_on_gp63.13621.34966YesYesYesNo87
262x42 3x46 s1p1_on_gp59.34490YesYesYesNo88
273x46 3x50 s1p1_on_gp24.03530YesNoYesYes89
283x50 G.H5.25 s1p1_on_gp33.39890YesYesYesNo97
29G.H5.20 G.H5.25 s1p1_on_gp30.53140YesNoYesNo97
30b.b28x4 b.b28x6 s1p1_on_gp20.21710YesNoYesNo69
31b.b28x4 b.l25x3 s1p1_on_gp20.47830YesNoYesNo69
326x29 G.H5.20 s1p1_on_gp23.55160NoNoYesNo69
336x29 G.H5.13 s1p1_on_gp22.80990NoNoYesNo68
34G.H5.13 G.S6.02 s1p1_on_gp21.66940YesNoYesNo87
35G.H5.10 G.S6.02 s1p1_on_gp21.33270NoNoYesNo67
36G.H5.10 G.S5.03 s1p1_on_gp21.17860NoNoYesNo68
37G.S4.03 G.S5.03 s1p1_on_gp15.26370NoNoYesNo78
38G.S1.04 G.S4.03 s1p1_on_gp15.71060NoNoNoNo77
39G.S1.04 G.S3.05 s1p1_on_gp15.62340NoNoYesNo77
40G.H2.04 G.H2.07 s1p1_on_gp11.43910YesNoYesNo99
41b.l5x5 b.l7x2 s1p1_on_gp27.96150YesNoYesNo99
42G.H1.08 G.S3.05 s1p1_on_gp13.410NoNoYesNo87
43G.H1.08 G.H5.04 s1p1_on_gp13.43140NoNoNoNo87
44G.H3.17 b.l25x6 s1p1_on_gp19.21170YesNoNoNo58
45G.H3.15 G.H3.17 s1p1_on_gp18.80960NoNoYesNo85
46G.H3.15 G.H3.18 s1p1_on_gp18.65930NoNoYesNo89
47G.H3.18 G.S4.02 s1p1_on_gp17.98960YesNoNoNo98
48G.S4.02 G.S5.02 s1p1_on_gp18.03470NoNoNoNo86
49G.H3.09 G.S5.02 s1p1_on_gp16.56090YesNoNoNo96
50G.H4.03 G.HG.01 s1p1_on_gp14.64120YesNoNoNo45
51G.HG.01 G.s6h5.02 s1p1_on_gp14.53090NoNoYesNo57
52G.H5.02 G.s6h5.02 s1p1_on_gp14.7240NoNoYesNo47
53G.H5.02 I3.R238 s1p1_on_gp14.78340NoNoNoNo40
54G.H5.09 I3.R238 s1p1_on_gp14.81950NoNoNoNo40
55G.H5.05 G.H5.09 s1p1_on_gp14.74730NoNoNoNo54
56G.H5.05 G.S2.08 s1p1_on_gp12.58650NoNoYesNo55
57b.l7x2 b.l9x6 s1p1_on_gp25.93690YesNoYesNo98
58G.H2.04 G.H3.08 s1p1_on_gp10.33690YesNoNoNo99
59G.H3.08 G.S4.04 s1p1_on_gp10.28310NoNoNoNo99
60G.H3.09 G.S4.04 s1p1_on_gp10.43610YesNoNoNo99
61g.ctx3 g.ctx6 s1p1_on_gp12.35520YesNoYesNo96
62b.l22x5 g.ctx6 s1p1_on_gp26.32380YesNoYesNo96
63b.l22x5 b.lhb1x3 s1p1_on_gp13.47250YesNoYesNo92
64b.h2x5 b.lhb1x3 s1p1_on_gp12.23270YesNoYesNo52
65b.h2x1 b.h2x5 s1p1_on_gp22.2740NoNoYesNo55
66b.b21x5 b.h2x1 s1p1_on_gp18.97630YesNoNoNo45
67b.b21x5 b.b21x7 s1p1_on_gp19.53060YesNoYesNo45
68b.b20x5 b.b21x7 s1p1_on_gp36.61370NoNoYesNo75
69b.b20x5 b.b21x4 s1p1_on_gp36.38310NoNoNoNo75
70b.b20x7 b.b21x4 s1p1_on_gp36.15710YesNoNoNo95
71b.b20x7 b.l20x2 s1p1_on_gp35.48620YesNoYesNo99
72b.l20x2 g.l1x5 s1p1_on_gp35.2410YesNoNoNo94
73g.l1x3 g.l1x5 s1p1_on_gp35.0240NoNoNoNo14
74g.l1x2 g.l1x3 s1p1_on_gp34.80690YesNoNoNo21
75b.b21x1 g.l1x2 s1p1_on_gp16.14730YesNoYesNo72
76b.1x19 b.b21x1 s1p1_on_gp10.57160NoNoYesNo67
77b.l22x5 b.l24x2 s1p1_on_gp11.92510YesNoNoNo96
78b.h2x5 b.l24x2 s1p1_on_gp11.53570YesNoNoNo56
79b.l11x1 b.l9x6 s1p1_on_gp32.98440NoNoYesNo98
80b.b11x6 b.l11x1 s1p1_on_gp32.82730NoNoNoNo99
81b.b11x6 b.l9x3 s1p1_on_gp31.41080NoNoYesNo99
82b.b11x4 b.l9x3 s1p1_on_gp24.46430YesNoYesNo99
83b.b10x3 b.b11x4 s1p1_on_gp25.46080NoNoYesNo89
84b.b10x3 b.b6x2 s1p1_on_gp25.43560NoNoNoNo88
85b.b10x2 b.b6x2 s1p1_on_gp24.9440NoNoNoNo68
86b.b10x2 b.b10x4 s1p1_on_gp14.21990NoNoNoNo66
87b.b10x4 b.b2x4 s1p1_on_gp13.97140NoNoNoNo66
88b.b2x4 b.b6x5 s1p1_on_gp13.72380NoNoYesNo66
89b.b3x3 b.b6x5 s1p1_on_gp12.97510YesNoYesNo86
90b.b3x3 b.b4x3 s1p1_on_gp10.14010YesNoYesNo87
91b.b10x2 b.b14x3 s1p1_on_gp15.60890NoNoYesNo65
92b.b17x5 g.l1x2 s1p1_on_gp16.92750YesNoYesNo72
93b.b16x5 b.b17x5 s1p1_on_gp11.57540YesNoYesNo57
94b.b14x3 b.b15x1 s1p1_on_gp12.63840YesNoYesNo59
95b.l21x7 b.l23x1 s1p1_on_gp32.55460YesNoYesNo56
96b.b23x6 b.l21x7 s1p1_on_gp31.35540YesNoYesNo75
97b.b21x7 b.b24x6 s1p1_on_gp29.7010YesNoNoNo58
98b.b24x5 b.b25x7 s1p1_on_gp13.4990NoNoYesNo57
992x46 3x46 s1p1_on_gp59.60160YesNoYesNo98
1002x46 3x43 s1p1_on_gp62.01790YesNoNoNo99
1014x42 4x46 s1p1_on_gp36.36740YesNoNoNo77
1022x45 4x50 s1p1_on_gp36.53696.81852NoNoNoYes99
1033x38 4x50 s1p1_on_gp35.9542.74447NoNoNoYes79
1043x38 4x53 s1p1_on_gp35.56840NoNoNoNo78
1053x37 4x53 s1p1_on_gp35.01082.07215NoYesNoNo68
1063x37 Lig s1p1_on_gp34.97380NoYesYesYes60
1077x38 Lig s1p1_on_gp11.35519.04119NoNoYesYes50
108E2.L195 Lig s1p1_on_gp18.8590YesNoYesYes30
1092x57 7x38 s1p1_on_gp10.92030YesYesNoNo65
1101x39 2x57 s1p1_on_gp11.40660YesNoYesYes66
1113x25 3x26 s1p1_on_gp10.14710YesYesYesYes96
1123x26 E2.N183 s1p1_on_gp10.14252.99533YesYesNoNo65
1136x58 7x31 s1p1_on_gp10.28916.96904YesYesYesYes43
114b.b23x1 g.ctx6 s1p1_on_gp17.09170NoNoYesNo56
115b.b23x6 b.b24x6 s1p1_on_gp29.50670YesNoNoNo78
116G.H5.04 G.S2.08 s1p1_on_gp13.34910NoNoYesNo75
117b.b23x1 b.b24x5 s1p1_on_gp12.97440NoNoNoNo55
1183x50 7x53 s1p1_on_gp12.88660YesYesYesNo99
1192x46 7x53 s1p1_on_gp12.97680YesNoYesNo99
1203x43 6x44 Shared61.1178100NoNoYesYes99
1216x44 6x48 Shared60.031195.5446YesYesYesYes98
1226x48 Lig Shared56.453588.2695YesYesYesYes80
1232x45 4x46 Shared36.232410.4009NoNoNoNo97
124Lig NT.Y29 Shared14.749812.0365YesYesYesYes07
1253x29 Lig Shared12.500510.5263YesYesYesYes50
1263x32 Lig Shared11.352517.6659NoNoYesYes60
1273x33 Lig Shared11.784351.6733YesNoYesYes50
1282x57 3x32 Shared11.013914.1287YesYesNoNo66
1293x26 E2.Y198 Shared10.157632.2914YesYesYesYes64
1303x33 E2.Y198 s1p1_off5.4817743.0034YesNoYesYes54
1313x26 E2.I185 s1p1_off028.5786YesYesNoYes63
132E2.I185 NT.I24 s1p1_off025.8341NoYesNoYes34
1333x28 E1x52 s1p1_off3.3936911.876YesYesNoNo65
134NT.H28 NT.I24 s1p1_off1.3106920.0793YesYesNoYes84
135E2.C191 NT.H28 s1p1_off0.43839911.018NoNoYesYes98
1361x39 7x39 s1p1_off0.0065769211.4545YesNoNoNo65
1372x57 7x39 s1p1_off1.7601717.1241YesYesNoNo65
1382x57 2x60 s1p1_off019.8485YesYesNoYes65
1392x60 Lig s1p1_off2.8831316.798NoYesYesYes50
1402x57 2x61 s1p1_off4.3954511.4545YesYesYesNo65
1411x49 7x50 s1p1_off2.3765218.6092NoNoNoYes89
1421x53 7x50 s1p1_off063.3586NoNoNoYes99
1431x53 7x53 s1p1_off064.0359NoNoYesNo99
1442x43 7x53 s1p1_off077.7733NoNoYesNo89
1452x43 3x46 s1p1_off097.2054NoNoYesNo88
1463x46 6x37 s1p1_off097.5265YesNoNoNo88
1475x58 6x37 s1p1_off097.8727YesYesNoNo98
1485x58 6x41 s1p1_off0.94237997.7221YesYesNoYes97
1493x43 6x41 s1p1_off099.8043NoNoNoYes97
1501x50 7x50 s1p1_off0.035327547.835YesYesNoYes99
1511x50 2x50 s1p1_off6.1424743.761YesYesYesYes99
1527x54 7x55 s1p1_off013.4915NoNoNoNo76
1537x51 7x55 s1p1_off1.4880814.786NoNoNoNo66
1541x49 7x51 s1p1_off1.784616.0704NoNoNoNo86
1558x50 I1x50 s1p1_off020.576YesNoYesYes88
1567x53 8x50 s1p1_off030.6407YesNoYesNo98
1572x40 I1x50 s1p1_off1.2437913.8026YesNoYesYes98
1582x50 7x49 s1p1_off2.6037111.4997YesYesNoNo99
1592x49 4x50 s1p1_off016.8531NoNoNoYes89
1602x49 3x39 s1p1_off018.0774NoNoNoNo89
1612x50 3x39 s1p1_off0.29821619.3016YesYesNoNo99
1622x37 2x40 s1p1_off3.7182112.478NoNoYesNo79
1632x39 2x43 s1p1_off0.31193430.8163YesNoNoNo88
1642x39 3x50 s1p1_off2.9759619.417YesNoYesYes89
1652x39 6x33 s1p1_off014.5351YesNoYesNo88
1662x50 7x46 s1p1_off1.784614.786YesYesNoNo99
1673x36 5x47 s1p1_off011.9362NoNoNoYes67
1683x37 5x47 s1p1_off014.3244NoYesNoYes67
1693x51 5x61 s1p1_off5.3678911.4746YesNoNoNo89
1703x50 5x61 s1p1_off015.6139YesYesNoNo99
1716x58 E2.V194 s1p1_off8.2671912.458YesYesNoNo44
172E2.L195 E2.V194 s1p1_off9.1312115.1172YesNoNoNo34
173E2.L195 E2.Y198 s1p1_off5.5576923.9677YesNoYesYes34
1745x40 6x59 s1p1_off011.5599NoNoYesNo64
1756x48 6x52 s1p1_off011.5248YesYesYesYes86
1768x47 8x50 s1p1_off0.0009395613.2708NoYesYesNo88
1776x36 8x47 s1p1_off013.4213NoNoNoYes98
1786x36 7x56 s1p1_off0.31437711.2087NoNoNoNo97
1792x53 2x54 s1p1_off0.29821610.8725NoNoNoNo87
1802x53 7x46 s1p1_off1.4880813.4915NoNoNoNo89

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
LigNT.Y29Shared8.793.162861101
LigNT.K34Shared5.773.317141101
2x60LigShared12.176.041431110
3x29LigShared14.458.367141110
3x32LigShared15.424.121430110
3x33LigShared15.7721.70431110
3x36LigShared3.778.202861110
6x48LigShared5.435.195711110
7x35Ligs1p1_off6.3201010
7x38LigShared17.939.018571010
NT.K34NT.Y29Shared5.975.972861111
E1x50NT.Y29Shared6.242.855710121
E1x501NT.Y29Shared5.964.395710121
3x25NT.Y29Shared10.614.682861121
E2.P196NT.Y29Shared20.8611.52290021
2x572x60s1p1_off9.300121
2x573x32Shared5.994.617140121
2x602x64s1p1_off7.4501111
2x603x29s1p1_off5.2601111
2x643x28s1p1_off3.9500012
3x28E1x50Shared7.764.618571122
3x253x28Shared106.857141122
3x253x29Shared8.7215.57711121
3x25E2.Y198Shared6.753.444291122
3x283x29Shared12.795.485711121
3x33E2.Y198Shared14.442.947141112
3x335x39Shared10.324.717141112
3x365x47s1p1_off7.3101111
3x366x48Shared17.085.042861111
3x373x41s1p1_off5.2800012
3x374x53Shared6.523.260012
3x375x47s1p1_off5.2800011
3x405x47s1p1_off6.5500021
E2.L195E2.V194Shared4.474.470112
E2.L195E2.Y198Shared11.726.364280112
5x40E2.L195s1p1_off5.7100021
5x39E2.Y198Shared7.944.112861122
5x395x43Shared9.417.681122
5x406x55Shared5.714.280021
5x446x52Shared3.893.705710022
5x476x52Shared6.436.735710112
6x446x48Shared14.038.017141121
6x447x45Shared8.463.452861122
6x486x52s1p1_off8.0201112
6x487x41Shared10.371.667141112
6x487x45Shared5.658.555711112
6x516x55s1p1_off5.5400011
6x517x38s1p1_off4.1500011
7x337x35s1p1_off10.4700021
7x337x36Shared7.22.205710022
7x357x38s1p1_off7.9501011
3x374x56s1p1_off300012
2x64E1x47Shared1.862.122860012
2x563x32s1p1_off1.6100021
2x64Ligs1p1_on_gp03.798570010
3x37Ligs1p1_on_gp05.044290010
5x47Ligs1p1_on_gp06.105710110
6x51Ligs1p1_on_gp06.062860010
6x55Ligs1p1_on_gp05.251430010
2x577x38s1p1_on_gp04.688570121
2x603x28s1p1_on_gp010.50431112
2x603x32s1p1_on_gp06.211431111
E1x50E1x501s1p1_on_gp05.174290122
3x25E2.L195s1p1_on_gp03.092861121
3x29E2.L195s1p1_on_gp04.168571111
3x29E2.Y198s1p1_on_gp05.611431112
3x335x43s1p1_on_gp03.191431112
3x406x48s1p1_on_gp04.027140021
5x446x55s1p1_on_gp02.947140021
5x476x48s1p1_on_gp011.45430111
E2.L195Ligs1p1_on_gp05.897140110
7x357x36s1p1_on_gp07.214291012
NT.I25NT.Y29s1p1_on_gp02.592860021
4x565x43s1p1_on_gp02.491430022

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
s1p1_on_gp 7VIE-S1P1-S1P-Gi1/β1/γ2
7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
7VIG-S1P1-CBP-307-Gi1/β1/γ2
7EVY-S1P1-Siponimod-Gi1/β1/γ2
7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
7EW0-S1P1-Ozanimod-Gi1/β1/γ2
7EW7-S1P1-SEW2871-Gi1/β1/γ2
s1p1_off 3V2W-S1P1-PubChem 51892645
Network Difference
Value s1p1_on_gp s1p1_off
Imin 2.64143 3.65
Number of Linked Nodes 909 261
Number of Specific Nodes 656 (72.17%) 8  (3.07%)
Number of Shared Nodes 253 (27.83%) 253  (96.93%)
Number of Links 1128 278
Number of Specific Links 965 (85.55%) 115  (41.37%)
Number of Shared Links 163 (14.45%) 163  (58.63%)
Number of Hubs 179 31
Number of Specific Hubs 158 (88.27%) 10  (32.26%)
Number of Shared Hubs 21 (11.73%) 21  (67.74%)
Average % Shared Neighbours (Jaccard) 12.21
Average % Shared Neighbours (Otsuka) 14.85
Average % Shared Neighbours (Overlap Coefficient) 17.54
Average % Shared Cliques (k3-6) 51.36
Graphlets Similarity 0.583979
Paths Difference
Value s1p1_on_gp s1p1_off
Number Of Nodes in MetaPath 126 65
Specific Nodes in MetaPath 105 (83.33%) 44  (67.69%)
Shared Nodes in MetaPath 253 (27.83%) 253  (27.83%)
Number Of Links MetaPath 129 61
Specific Links in MetaPath 119 (92.25%) 51  (83.61%)
Shared Links in MetaPath 163 (14.45%) 163  (14.45%)
Number of Shortest Paths 1088110 38970
Length Of Smallest Path 3 3
Average Path Length 26.3266 14.465
Length of Longest Path 59 33
Minimum Path Strength 0.370714 1.51
Average Path Strength 5.29415 6.84427
Maximum Path Strength 18.4907 21.075
Minimum Path Correlation 0.712857 0.7
Average Path Correlation 0.979333 0.916381
Maximum Path Correlation 1 0.99
Minimum % Of Corr. Nodes 2.12766 4.16667
Average % Of Corr. Nodes 49.7871 47.0132
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 50.7692 40.9882
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download s1p1_off_on_gp.zip<



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