CodeHRG
NameL-homoarginine
SynonymsN6-amidino-Lysine
Identifier(2S)-2-amino-6-carbamimidamido-hexanoic acid
FormulaC7 H16 N4 O2
Molecular Weight188.228
SMILESC(CCNC(=N)N)C[C@@H](C(=O)O)N
PubChem9085
Formal Charge0
Total Atoms29
Total Chiral Atoms1
Total Bonds28
Total Aromatic Bonds0
Networks3
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This ligand is also present in the following 3 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5VBL A Peptide Apelin Apelin Homo sapiens Apelin Mimetic Peptide Agonist - - 2.6 2017-05-31 10.1016/j.str.2017.04.008

A 2D representation of the interactions of HRG in 5VBL
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?9 R:R:E20 11.33 0 Yes No 0 5 1 2
R:R:D23 R:R:T176 5.78 1 No No 5 3 1 2
R:R:D23 R:R:K178 8.3 1 No Yes 5 2 1 2
L:L:?8 R:R:D23 8.49 0 No No 0 5 0 1
L:L:?8 R:R:N175 10.74 0 No No 0 2 0 1
R:R:K178 R:R:T176 6.01 1 Yes No 2 3 2 2
L:L:E10 R:R:T176 4.23 1 Yes No 0 3 2 2
L:L:?8 L:L:?9 18.52 0 No Yes 0 0 0 1
L:L:?9 L:L:E10 4.53 0 Yes Yes 0 0 1 2
L:L:?9 R:R:T22 2.52 0 Yes No 0 4 1 2
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub1.00
Average Interaction Strength12.58
Average Nodes In Shell9.00
Average Hubs In Shell3.00
Average Links In Shell10.00
Average Links Mediated by Hubs In Shell7.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6FJ3 B1 Peptide Parathyroid hormone PTH1 Homo sapiens PTH - - 2.5 2018-11-21 10.1038/s41594-018-0151-4

A 2D representation of the interactions of HRG in 6FJ3
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?11 R:R:G188 4.01 0 Yes No 0 5 0 1
R:R:D241 R:R:Y245 4.6 0 No No 8 4 2 1
R:R:L244 R:R:W352 3.42 0 No Yes 5 8 1 2
L:L:?11 R:R:L244 6.5 0 Yes No 0 5 0 1
L:L:?11 R:R:Y245 8.25 0 Yes No 0 4 0 1
L:L:?11 L:L:L15 4.33 0 Yes No 0 0 0 1
L:L:L15 L:L:W14 3.42 0 No Yes 0 0 1 2
L:L:?11 L:L:L7 3.25 0 Yes No 0 0 0 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub0.00
Average Interaction Strength5.27
Average Nodes In Shell9.00
Average Hubs In Shell3.00
Average Links In Shell8.00
Average Links Mediated by Hubs In Shell7.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8FLT B1 Peptide Parathyroid hormone PTH1 Homo Sapiens M-PTH(1-14) - Gs/Beta1/Gamma2 3.03 2023-04-26 10.1016/j.str.2023.04.002

A 2D representation of the interactions of HRG in 8FLT
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?11 R:R:F184 6.67 0 No Yes 0 6 0 1
L:L:?11 R:R:D241 4.25 0 No Yes 0 8 0 1
L:L:?11 R:R:Y245 28.42 0 No No 0 4 0 1
L:L:W14 R:R:F184 4.01 0 No Yes 0 6 2 1
R:R:F184 R:R:V432 3.93 1 Yes No 6 5 1 2
R:R:F184 R:R:W437 5.01 1 Yes Yes 6 5 1 2
R:R:D241 R:R:Y191 10.34 0 Yes Yes 8 7 1 2
R:R:D241 R:R:I237 4.2 0 Yes Yes 8 7 1 2
R:R:D241 R:R:K240 4.15 0 Yes No 8 7 1 2
R:R:L244 R:R:Y245 17.58 16 Yes No 5 4 2 1
R:R:D353 R:R:L244 12.21 16 Yes Yes 5 5 2 2
R:R:D353 R:R:Y245 8.05 16 Yes No 5 4 2 1
R:R:V432 R:R:W437 12.26 1 No Yes 5 5 2 2
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub2.00
Average Interaction Strength13.11
Average Nodes In Shell12.00
Average Hubs In Shell7.00
Average Links In Shell13.00
Average Links Mediated by Hubs In Shell12.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links3.67
Average Number Of Links With An Hub1.00
Average Interaction Strength10.32
Average Nodes In Shell10.00
Average Hubs In Shell4.33
Average Links In Shell10.33
Average Links Mediated by Hubs In Shell8.67

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)