psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	I:I:?1	R:R:N76	8.15	Yes	No	1	0	9
2	I:I:?1	R:R:D104	8.06	Yes	Yes	1	0	9
3	I:I:?1	R:R:N322	8.15	Yes	Yes	1	0	9
4	I:I:?1	R:R:P323	6.5	Yes	Yes	1	0	9
5	I:I:?1	R:R:Y326	4.64	Yes	Yes	1	0	9
6	R:R:F56	R:R:R54	7.48	No	No	0	4	4
7	R:R:K57	R:R:R54	8.66	No	No	0	4	4
8	R:R:F56	R:R:W59	6.01	No	No	0	4	1
9	R:R:I63	R:R:W59	3.52	No	No	0	5	1
10	R:R:F60	R:R:L61	7.31	No	No	0	5	6
11	R:R:F60	R:R:M64	8.71	No	Yes	0	5	5
12	R:R:L61	R:R:Y65	11.72	No	Yes	0	6	7
13	R:R:M64	R:R:Y65	4.79	Yes	Yes	0	5	7
14	R:R:M64	R:R:S313	6.13	Yes	No	0	5	5
15	R:R:L111	R:R:Y65	11.72	Yes	Yes	0	8	7
16	R:R:Y312	R:R:Y65	6.95	Yes	Yes	0	5	7
17	R:R:C69	R:R:L111	4.76	No	Yes	0	6	8
18	R:R:C320	R:R:V71	6.83	No	No	0	7	5
19	R:R:F324	R:R:V71	3.93	No	No	0	6	5
20	R:R:C320	R:R:G72	3.92	No	No	0	7	8
21	R:R:I105	R:R:L73	4.28	No	No	0	7	5
22	R:R:L109	R:R:L73	4.15	No	No	0	4	5
23	R:R:G75	R:R:P323	4.06	No	Yes	0	7	9
24	R:R:D104	R:R:N76	10.77	Yes	No	1	9	9
25	R:R:N76	R:R:P323	9.77	No	Yes	1	9	9
26	R:R:L337	R:R:L78	4.15	No	No	0	6	6
27	R:R:P323	R:R:V79	3.53	Yes	No	0	9	9
28	R:R:V79	R:R:Y326	5.05	No	Yes	0	9	9
29	R:R:F333	R:R:T82	7.78	Yes	No	1	8	6
30	R:R:L337	R:R:T82	4.42	No	No	1	6	6
31	R:R:T82	W:W:?1	4.21	No	Yes	1	6	0
32	R:R:K90	R:R:Y83	20.3	No	No	4	6	7
33	R:R:T95	R:R:Y83	6.24	No	No	4	5	7
34	R:R:L98	R:R:Y83	16.41	No	No	0	6	7
35	R:R:L340	R:R:Y85	8.21	No	No	0	5	4
36	R:R:F86	R:R:L89	3.65	No	No	0	5	7
37	R:R:D336	R:R:F86	21.5	Yes	No	0	5	5
38	R:R:K87	R:R:K90	5.75	No	No	0	6	6
39	R:R:K332	R:R:L89	4.23	Yes	No	0	7	7
40	R:R:K90	R:R:T95	7.51	No	No	4	6	5
41	R:R:T91	R:R:T93	4.71	No	Yes	1	7	7
42	R:R:D94	R:R:T91	13.01	No	No	1	8	7
43	R:R:T91	W:W:?1	14.33	No	Yes	1	7	0
44	R:R:M92	R:R:Y96	7.18	Yes	Yes	0	6	7
45	R:R:D153	R:R:M92	9.7	No	Yes	0	8	6
46	R:R:M92	R:R:S175	4.6	Yes	No	0	6	8
47	R:R:I150	R:R:T93	4.56	No	Yes	0	8	7
48	R:R:D153	R:R:T93	7.23	No	Yes	0	8	7
49	R:R:T93	W:W:?1	15.17	Yes	Yes	1	7	0
50	R:R:D94	R:R:K332	8.3	No	Yes	1	8	7
51	R:R:D94	W:W:?1	25.61	No	Yes	1	8	0
52	R:R:C149	R:R:Y96	13.44	No	Yes	0	6	7
53	R:R:I150	R:R:Y96	6.04	No	Yes	0	8	7
54	R:R:S178	R:R:Y96	5.09	No	Yes	0	5	7
55	R:R:L97	R:R:Y326	11.72	No	Yes	1	7	9
56	R:R:L97	W:W:?1	7.91	No	Yes	1	7	0
57	R:R:C179	R:R:N99	11.02	No	No	0	7	9
58	R:R:N99	R:R:W183	7.91	No	Yes	0	9	9
59	R:R:D104	R:R:L100	4.07	Yes	No	0	9	9
60	R:R:L100	R:R:L146	4.15	No	No	0	9	8
61	R:R:V102	R:R:W183	3.68	No	Yes	0	5	9
62	R:R:A103	R:R:W183	3.89	No	Yes	0	8	9
63	R:R:D104	R:R:R318	10.72	Yes	Yes	1	9	9
64	R:R:C319	R:R:D104	10.89	Yes	Yes	1	8	9
65	R:R:D104	R:R:N322	4.04	Yes	Yes	1	9	9
66	R:R:F107	R:R:L111	3.65	Yes	Yes	1	6	8
67	R:R:F107	R:R:Y136	11.35	Yes	Yes	1	6	6
68	R:R:F107	R:R:S139	5.28	Yes	No	0	6	8
69	R:R:C316	R:R:F107	5.59	Yes	Yes	1	7	6
70	R:R:C319	R:R:F107	4.19	Yes	Yes	1	8	6
71	R:R:C319	R:R:L108	4.76	Yes	No	0	8	5
72	R:R:I132	R:R:T110	6.08	Yes	No	0	5	6
73	R:R:C316	R:R:L111	6.35	Yes	Yes	1	7	8
74	R:R:F113	R:R:F124	9.65	No	Yes	0	6	7
75	R:R:F113	R:R:F128	13.93	No	No	0	6	5
76	R:R:W114	R:R:W122	5.62	Yes	Yes	2	6	9
77	R:R:I132	R:R:W114	10.57	Yes	Yes	2	5	6
78	R:R:F133	R:R:W114	4.01	No	Yes	0	5	6
79	R:R:W114	R:R:Y312	5.79	Yes	Yes	0	6	5
80	R:R:K120	R:R:Y116	3.58	No	No	0	4	3
81	R:R:V123	R:R:Y116	6.31	No	No	2	2	3
82	R:R:F124	R:R:Y116	8.25	Yes	No	2	7	3
83	R:R:S117	R:R:W122	7.41	No	Yes	0	5	9
84	R:R:R209	R:R:S117	9.22	No	No	0	4	5
85	R:R:F124	R:R:W122	14.03	Yes	Yes	2	7	9
86	R:R:C129	R:R:W122	3.92	No	Yes	2	9	9
87	R:R:I132	R:R:W122	3.52	Yes	Yes	2	5	9
88	R:R:L199	R:R:W122	6.83	No	Yes	0	4	9
89	R:R:C210	R:R:W122	20.89	No	Yes	2	9	9
90	R:R:F124	R:R:V123	7.87	Yes	No	2	7	2
91	R:R:L199	R:R:V126	5.96	No	No	0	4	2
92	R:R:F128	R:R:L131	3.65	No	No	0	5	4
93	R:R:F128	R:R:I132	7.54	No	Yes	0	5	5
94	R:R:C129	R:R:C210	7.28	No	No	2	9	9
95	R:R:F133	R:R:S197	13.21	No	No	0	5	5
96	R:R:F133	R:R:L212	9.74	No	No	0	5	5
97	R:R:I135	R:R:M138	5.83	No	Yes	0	4	5
98	R:R:K137	R:R:Y136	4.78	Yes	Yes	1	5	6
99	R:R:Q276	R:R:Y136	13.53	Yes	Yes	1	8	6
100	R:R:Y136	R:R:Y279	8.94	Yes	Yes	1	6	6
101	R:R:N280	R:R:Y136	10.47	Yes	Yes	1	8	6
102	R:R:F141	R:R:K137	3.72	No	Yes	0	7	5
103	R:R:E193	R:R:K137	10.8	No	Yes	0	4	5
104	R:R:K137	R:R:N280	6.99	Yes	Yes	1	5	8
105	R:R:M138	R:R:T187	6.02	Yes	No	0	5	3
106	R:R:M138	R:R:S190	6.13	Yes	No	0	5	7
107	R:R:F140	R:R:F141	9.65	Yes	No	0	7	7
108	R:R:F140	R:R:M144	4.98	Yes	Yes	1	7	7
109	R:R:F140	R:R:F232	10.72	Yes	Yes	1	7	8
110	R:R:F140	R:R:Q276	12.88	Yes	Yes	1	7	8
111	R:R:F140	R:R:N280	12.08	Yes	Yes	1	7	8
112	R:R:F141	R:R:G231	9.03	No	No	0	7	5
113	R:R:G143	R:R:S142	3.71	No	No	0	9	6
114	R:R:S142	R:R:W183	8.65	No	Yes	0	6	9
115	R:R:F272	R:R:G143	4.52	Yes	No	0	9	9
116	R:R:F232	R:R:M144	8.71	Yes	Yes	1	8	7
117	R:R:M144	R:R:P235	6.71	Yes	No	1	7	9
118	R:R:F272	R:R:M144	6.22	Yes	Yes	1	9	7
119	R:R:I182	R:R:W145	4.7	No	Yes	0	6	5
120	R:R:L185	R:R:W145	9.11	No	Yes	0	4	5
121	R:R:V234	R:R:W145	4.9	No	Yes	1	5	5
122	R:R:P235	R:R:W145	16.21	No	Yes	1	9	5
123	R:R:I182	R:R:L146	5.71	No	No	0	6	8
124	R:R:L147	R:R:V269	7.45	No	No	0	8	7
125	R:R:F272	R:R:L147	3.65	Yes	No	0	9	8
126	R:R:L148	R:R:S151	4.5	Yes	Yes	3	7	9
127	R:R:I152	R:R:L148	4.28	No	Yes	0	5	7
128	R:R:A238	R:R:L148	4.73	No	Yes	0	7	7
129	R:R:L148	R:R:M239	7.07	Yes	Yes	3	7	7
130	R:R:I150	R:R:I265	8.83	No	No	0	8	7
131	R:R:M239	R:R:S151	6.13	Yes	Yes	3	7	9
132	R:R:S151	R:R:Y243	10.17	Yes	Yes	3	9	8
133	R:R:D153	R:R:R154	15.48	No	No	0	8	9
134	R:R:A157	R:R:R154	5.53	No	No	0	8	9
135	R:R:R154	W:W:?1	11.81	No	Yes	0	9	0
136	R:R:V159	R:R:Y155	6.31	No	Yes	0	7	8
137	R:R:F241	R:R:Y155	7.22	No	Yes	0	3	8
138	R:R:C242	R:R:Y155	4.03	No	Yes	0	7	8
139	R:R:R168	R:R:V171	3.92	No	No	0	7	6
140	R:R:C179	R:R:K176	6.47	No	No	0	7	3
141	R:R:I191	R:R:L194	4.28	No	No	0	4	4
142	R:R:P192	R:R:Q227	4.74	No	Yes	0	8	5
143	R:R:I213	R:R:Y196	4.84	No	No	0	4	4
144	R:R:F220	R:R:Y196	6.19	Yes	No	5	4	4
145	R:R:Q224	R:R:Y196	4.51	No	No	5	5	4
146	R:R:D198	R:R:I213	4.2	No	No	0	4	4
147	R:R:Q200	R:R:S211	4.33	No	No	0	3	4
148	R:R:E205	R:R:Q206	3.82	No	No	0	4	5
149	R:R:I213	R:R:V217	7.68	No	No	0	4	2
150	R:R:E218	R:R:I221	5.47	No	No	0	1	2
151	R:R:F220	R:R:I221	11.3	Yes	No	0	4	2
152	R:R:F220	R:R:Q224	15.23	Yes	No	5	4	5
153	R:R:F220	R:R:T287	11.67	Yes	No	0	4	4
154	R:R:I223	R:R:T222	4.56	No	No	0	4	1
155	R:R:I223	R:R:Q227	4.12	No	Yes	0	4	5
156	R:R:Q224	R:R:Q227	8.96	No	Yes	0	5	5
157	R:R:F232	R:R:L233	3.65	Yes	No	0	8	4
158	R:R:F232	R:R:L236	8.53	Yes	No	0	8	6
159	R:R:P235	R:R:V234	3.53	No	No	1	9	5
160	R:R:M239	R:R:Y243	3.59	Yes	Yes	3	7	8
161	R:R:M239	R:R:V269	4.56	Yes	No	0	7	7
162	R:R:F241	R:R:V245	3.93	No	No	0	3	3
163	R:R:I265	R:R:Y243	4.84	No	Yes	0	7	8
164	R:R:E257	R:R:N259	15.77	No	No	0	5	5
165	R:R:I262	R:R:V264	7.68	Yes	No	0	5	7
166	R:R:I262	W:W:?1	4.08	Yes	Yes	0	5	0
167	R:R:I266	R:R:K263	4.36	No	No	0	4	5
168	R:R:I329	R:R:V264	10.75	No	No	0	6	7
169	R:R:G330	R:R:V264	3.68	No	No	0	8	7
170	R:R:N322	R:R:V268	10.35	Yes	No	0	9	8
171	R:R:L325	R:R:V268	4.47	No	No	0	7	8
172	R:R:F275	R:R:V271	7.87	Yes	No	0	7	6
173	R:R:F272	R:R:Q276	4.68	Yes	Yes	1	9	8
174	R:R:F272	R:R:R318	13.9	Yes	Yes	1	9	9
175	R:R:F275	R:R:V274	5.24	Yes	No	0	7	5
176	R:R:F275	R:R:L314	3.65	Yes	No	0	7	7
177	R:R:F275	R:R:V317	3.93	Yes	No	0	7	5
178	R:R:F275	R:R:R318	8.55	Yes	Yes	0	7	9
179	R:R:Q276	R:R:R318	8.18	Yes	Yes	1	8	9
180	R:R:P278	R:R:T311	3.5	No	Yes	0	9	6
181	R:R:N280	R:R:Y279	5.81	Yes	Yes	1	8	6
182	R:R:V283	R:R:Y279	8.83	No	Yes	0	5	6
183	R:R:Y279	R:R:Y308	6.95	Yes	No	0	6	4
184	R:R:T311	R:R:Y279	3.75	Yes	Yes	0	6	6
185	R:R:Y279	R:R:Y312	12.91	Yes	Yes	0	6	5
186	R:R:T311	R:R:V282	6.35	Yes	No	0	6	5
187	R:R:L304	R:R:Q286	3.99	No	No	0	6	5
188	R:R:I306	R:R:K302	4.36	No	No	0	2	3
189	R:R:C316	R:R:Y312	5.38	Yes	Yes	0	7	5
190	R:R:C319	R:R:R318	5.57	Yes	Yes	1	8	9
191	R:R:N322	R:R:R318	4.82	Yes	Yes	1	9	9
192	R:R:F333	R:R:Y326	4.13	Yes	Yes	1	8	9
193	R:R:Y326	W:W:?1	6.03	Yes	Yes	1	9	0
194	R:R:F328	R:R:I329	6.28	No	No	0	7	6
195	R:R:D336	R:R:K332	11.06	Yes	Yes	1	5	7
196	R:R:K332	W:W:?1	22.57	Yes	Yes	1	7	0
197	R:R:F333	R:R:L337	4.87	Yes	No	1	8	6
198	R:R:F333	W:W:?1	4.18	Yes	Yes	1	8	0
199	R:R:D336	W:W:?1	4.66	Yes	Yes	1	5	0
200	R:R:F338	R:R:F341	9.65	No	No	0	4	5
201	R:R:C242	R:R:S151	3.44	No	Yes	0	7	9
202	R:R:G72	R:R:L108	3.42	No	No	0	8	5
203	R:R:A101	R:R:V79	3.39	No	No	0	9	9
204	R:R:H165	R:R:R166	3.39	No	No	0	5	4
205	R:R:I191	R:R:P192	3.39	No	No	0	4	8
206	R:R:H256	R:R:R258	3.39	No	No	0	3	6
207	R:R:A307	R:R:V282	3.39	No	No	0	5	5
208	R:R:Q286	R:R:Y308	3.38	No	No	0	5	4
209	R:R:C298	R:R:T297	3.38	No	No	0	5	5
210	R:R:L277	R:R:P278	3.28	No	No	0	5	9
211	R:R:C316	R:R:I68	3.27	Yes	No	0	7	6
212	R:R:S202	R:R:S204	3.26	No	No	0	1	6
213	R:R:C69	R:R:L73	3.17	No	No	0	6	5
214	R:R:A267	R:R:L325	3.15	No	No	0	5	7
215	R:R:I84	R:R:V80	3.07	No	No	0	2	7
216	R:R:I230	R:R:V229	3.07	No	No	0	4	4
217	R:R:I262	R:R:V331	3.07	Yes	No	0	5	5
218	R:R:K176	R:R:T95	3	No	No	0	3	5
219	R:R:L98	R:R:V80	2.98	No	No	0	6	7
220	R:R:L106	R:R:V102	2.98	No	No	0	6	5
221	R:R:L233	R:R:V229	2.98	No	No	0	4	4
222	R:R:L325	R:R:V321	2.98	No	No	0	7	6
223	R:R:I273	R:R:M144	2.92	No	Yes	0	5	7
224	R:R:I158	R:R:K249	2.91	Yes	No	0	8	5
225	R:R:I158	R:R:L250	2.85	Yes	No	0	8	8
226	R:R:K130	R:R:L194	2.82	No	No	0	7	4
227	R:R:K176	R:R:L172	2.82	No	No	0	3	2
228	R:R:G125	R:R:W122	2.81	No	Yes	0	7	9
229	R:R:H127	R:R:V126	2.77	No	No	0	1	2
230	R:R:L185	R:R:L189	2.77	No	No	0	4	5
231	R:R:L233	R:R:L237	2.77	No	No	0	4	4
232	R:R:A327	R:R:F333	2.77	No	Yes	0	7	8
233	R:R:D336	R:R:K339	2.77	Yes	No	0	5	4
234	R:R:L189	R:R:Q227	2.66	No	Yes	0	5	5
235	R:R:N305	R:R:Q286	2.64	No	No	0	4	5
236	R:R:V156	R:R:Y155	2.52	No	Yes	0	6	8
237	R:R:K87	R:R:R88	2.48	No	No	0	6	6
238	R:R:F70	R:R:L74	2.44	No	No	0	5	4
239	R:R:F220	R:R:L284	2.44	Yes	No	0	4	5
240	R:R:L173	R:R:R170	2.43	No	No	0	4	5
241	R:R:I246	R:R:Y155	2.42	No	Yes	0	8	8
242	R:R:I246	R:R:Y243	2.42	No	Yes	0	8	8
243	R:R:I266	R:R:Y243	2.42	No	Yes	0	4	8
244	R:R:M138	R:R:W183	2.33	Yes	Yes	0	5	9
245	R:R:D309	R:R:Y308	2.3	No	No	0	5	4
246	R:R:C69	R:R:P112	1.88	No	No	0	6	9
247	R:R:A115	R:R:P62	1.87	No	Yes	0	7	6
248	R:R:A118	R:R:P62	1.87	No	Yes	0	5	6
249	R:R:A119	R:R:P62	1.87	No	Yes	0	4	6
250	R:R:G181	R:R:I184	1.76	No	No	0	2	4
251	R:R:G75	R:R:L74	1.71	No	No	0	7	4
252	R:R:A207	R:R:S121	1.71	No	No	0	1	5
253	R:R:A186	R:R:S142	1.71	No	No	0	7	6
254	R:R:G281	R:R:L284	1.71	No	No	0	6	5
255	R:R:L61	R:R:P62	1.64	No	Yes	0	6	6
256	R:R:A157	R:R:I158	1.62	No	Yes	0	8	8
257	R:R:V225	R:R:V229	1.6	No	No	0	4	4
258	R:R:T311	R:R:V310	1.59	Yes	No	0	6	5
259	R:R:A134	R:R:L194	1.58	No	No	0	5	4
260	R:R:I67	R:R:V71	1.54	No	No	0	5	5
261	R:R:I184	R:R:V180	1.54	No	No	0	4	3
262	R:R:I184	R:R:V188	1.54	No	No	0	4	4
263	R:R:I266	R:R:V270	1.54	No	No	0	4	4
264	R:R:M92	R:R:V171	1.52	Yes	No	0	6	6
265	R:R:A315	R:R:Q276	1.52	No	Yes	0	8	8
266	R:R:C298	R:R:E299	1.52	No	No	0	5	5
267	R:R:L236	R:R:S240	1.5	No	No	0	6	4
268	R:R:L189	R:R:V188	1.49	No	No	0	5	4
269	R:R:I63	R:R:M64	1.46	No	Yes	0	5	5
270	R:R:I174	R:R:M92	1.46	No	Yes	0	3	6
271	R:R:Q200	R:R:S202	1.44	No	No	0	3	1
272	R:R:Q200	R:R:T214	1.42	No	No	0	3	5
273	R:R:L199	R:R:M208	1.41	No	No	0	4	5
274	R:R:L284	R:R:M228	1.41	No	No	0	5	5
275	R:R:D309	R:R:I306	1.4	No	No	0	5	2
276	R:R:K339	R:R:N335	1.4	No	No	0	4	5
277	R:R:A327	R:R:R334	1.38	No	No	0	7	8
278	R:R:L250	R:R:N259	1.37	No	No	0	8	5
279	R:R:L300	R:R:Q303	1.33	No	No	0	3	3
280	R:R:R209	R:R:S121	1.32	No	No	0	4	5
281	R:R:R201	R:R:S203	1.32	No	No	0	1	2
282	R:R:R209	R:R:S202	1.32	No	No	0	4	1
283	R:R:I158	R:R:R258	1.25	Yes	No	0	8	6
284	R:R:I262	R:R:R258	1.25	Yes	No	0	5	6
285	R:R:E215	R:R:H216	1.23	No	No	0	6	2
286	R:R:F86	R:R:L340	1.22	No	No	0	5	5
287	R:R:N55	R:R:R54	1.21	No	No	0	5	4
288	R:R:Q206	R:R:R201	1.17	No	No	0	5	1
289	R:R:H167	R:R:R166	1.13	No	No	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	I:I:?1	7.1	5	1	0
2	R:R:P62	1.8125	4	0	6
3	R:R:M64	5.2725	4	0	5
4	R:R:Y65	8.795	4	0	7
5	R:R:M92	4.892	5	0	6
6	R:R:T93	7.9175	4	1	7
7	R:R:Y96	7.9375	4	0	7
8	R:R:D104	8.09167	6	1	9
9	R:R:F107	6.012	5	1	6
10	R:R:L111	6.62	4	1	8
11	R:R:W114	6.4975	4	2	6
12	R:R:W122	8.12875	8	2	9
13	R:R:F124	9.95	4	2	7
14	R:R:I132	6.9275	4	2	5
15	R:R:Y136	9.814	5	1	6
16	R:R:K137	6.5725	4	1	5
17	R:R:M138	5.0775	4	0	5
18	R:R:F140	10.062	5	1	7
19	R:R:M144	5.908	5	1	7
20	R:R:W145	8.73	4	1	5
21	R:R:L148	5.145	4	3	7
22	R:R:S151	6.06	4	3	9
23	R:R:Y155	4.5	5	0	8
24	R:R:I158	2.1575	4	0	8
25	R:R:W183	5.292	5	0	9
26	R:R:F220	9.366	5	5	4
27	R:R:Q227	5.12	4	0	5
28	R:R:F232	7.9025	4	1	8
29	R:R:M239	5.3375	4	3	7
30	R:R:Y243	4.688	5	3	8
31	R:R:I262	4.02	4	0	5
32	R:R:F272	6.594	5	1	9
33	R:R:F275	5.848	5	0	7
34	R:R:Q276	8.158	5	1	8
35	R:R:Y279	7.865	6	1	6
36	R:R:N280	8.8375	4	1	8
37	R:R:T311	3.7975	4	0	6
38	R:R:Y312	7.7575	4	0	5
39	R:R:C316	5.1475	4	1	7
40	R:R:R318	8.62333	6	1	9
41	R:R:C319	6.3525	4	1	8
42	R:R:N322	6.84	4	1	9
43	R:R:P323	5.965	4	1	9
44	R:R:Y326	6.314	5	1	9
45	R:R:K332	11.54	4	1	7
46	R:R:F333	4.746	5	1	8
47	R:R:D336	9.9975	4	1	5
48	W:W:?1	10.96	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	I:I:?1	R:R:D104	77.6008	8.06	Yes	Yes	1	0	9
2	R:R:C319	R:R:D104	44.7225	10.89	Yes	Yes	1	8	9
3	R:R:C319	R:R:F107	57.2304	4.19	Yes	Yes	1	8	6
4	R:R:F107	R:R:L111	35.6529	3.65	Yes	Yes	1	6	8
5	R:R:L111	R:R:Y65	23.4168	11.72	Yes	Yes	0	8	7
6	R:R:M64	R:R:Y65	21.0656	4.79	Yes	Yes	0	5	7
7	R:R:I63	R:R:M64	14.3661	1.46	No	Yes	0	5	5
8	R:R:I63	R:R:W59	12.0023	3.52	No	No	0	5	1
9	R:R:L61	R:R:Y65	14.1259	11.72	No	Yes	0	6	7
10	R:R:C316	R:R:F107	24.5355	5.59	Yes	Yes	1	7	6
11	R:R:C316	R:R:Y312	22.8795	5.38	Yes	Yes	0	7	5
12	R:R:C69	R:R:L111	15.9209	4.76	No	Yes	0	6	8
13	R:R:C319	R:R:L108	11.4082	4.76	Yes	No	0	8	5
14	I:I:?1	R:R:P323	12.5332	6.5	Yes	Yes	1	0	9
15	R:R:G75	R:R:P323	11.958	4.06	No	Yes	0	7	9
16	I:I:?1	R:R:Y326	100	4.64	Yes	Yes	1	0	9
17	R:R:F333	R:R:Y326	10.9152	4.13	Yes	Yes	1	8	9
18	R:R:D104	R:R:R318	35.7793	10.72	Yes	Yes	1	9	9
19	R:R:F272	R:R:R318	51.9277	13.9	Yes	Yes	1	9	9
20	R:R:F272	R:R:G143	51.3399	4.52	Yes	No	0	9	9
21	R:R:G143	R:R:S142	49.2352	3.71	No	No	0	9	6
22	R:R:S142	R:R:W183	44.988	8.65	No	Yes	0	6	9
23	R:R:N99	R:R:W183	27.4934	7.91	No	Yes	0	9	9
24	R:R:C179	R:R:N99	25.2433	11.02	No	No	0	7	9
25	R:R:C179	R:R:K176	22.987	6.47	No	No	0	7	3
26	R:R:K176	R:R:T95	18.4364	3	No	No	0	3	5
27	I:I:?1	R:R:N322	32.4611	8.15	Yes	Yes	1	0	9
28	R:R:N322	R:R:R318	37.3278	4.82	Yes	Yes	1	9	9
29	R:R:Y326	W:W:?1	85.0777	6.03	Yes	Yes	1	9	0
30	R:R:D336	W:W:?1	13.4939	4.66	Yes	Yes	1	5	0
31	R:R:T93	W:W:?1	25.0032	15.17	Yes	Yes	1	7	0
32	R:R:D153	R:R:T93	12.6469	7.23	No	Yes	0	8	7
33	R:R:D153	R:R:M92	19.5677	9.7	No	Yes	0	8	6
34	R:R:R154	W:W:?1	25.6162	11.81	No	Yes	0	9	0
35	R:R:D153	R:R:R154	12.8239	15.48	No	No	0	8	9
36	R:R:I150	R:R:T93	13.3106	4.56	No	Yes	0	8	7
37	R:R:D104	R:R:L100	20.8634	4.07	Yes	No	0	9	9
38	R:R:L100	R:R:L146	19.416	4.15	No	No	0	9	8
39	R:R:Q276	R:R:R318	33.5482	8.18	Yes	Yes	1	8	9
40	R:R:Q276	R:R:Y136	54.5633	13.53	Yes	Yes	1	8	6
41	R:R:F107	R:R:Y136	26.5706	11.35	Yes	Yes	1	6	6
42	R:R:W114	R:R:Y312	50.2339	5.79	Yes	Yes	0	6	5
43	R:R:W114	R:R:W122	36.4556	5.62	Yes	Yes	2	6	9
44	R:R:S117	R:R:W122	15.9145	7.41	No	Yes	0	5	9
45	R:R:R209	R:R:S117	14.1765	9.22	No	No	0	4	5
46	R:R:Y136	R:R:Y279	46.4164	8.94	Yes	Yes	1	6	6
47	R:R:F140	R:R:Q276	16.2874	12.88	Yes	Yes	1	7	8
48	R:R:F140	R:R:N280	22.6773	12.08	Yes	Yes	1	7	8
49	R:R:F272	R:R:M144	33.8326	6.22	Yes	Yes	1	9	7
50	R:R:F232	R:R:M144	12.1792	8.71	Yes	Yes	1	8	7
51	R:R:F140	R:R:F232	12.5332	10.72	Yes	Yes	1	7	8
52	R:R:M144	R:R:P235	39.1543	6.71	Yes	No	1	7	9
53	R:R:I182	R:R:L146	18.1583	5.71	No	No	0	6	8
54	R:R:I182	R:R:W145	18.1077	4.7	No	Yes	0	6	5
55	R:R:L185	R:R:W145	49.4375	9.11	No	Yes	0	4	5
56	R:R:F272	R:R:L147	37.3531	3.65	Yes	No	0	9	8
57	R:R:L147	R:R:V269	35.5581	7.45	No	No	0	8	7
58	R:R:M239	R:R:V269	34.452	4.56	Yes	No	0	7	7
59	R:R:I150	R:R:I265	12.5458	8.83	No	No	0	8	7
60	R:R:I265	R:R:Y243	13.3738	4.84	No	Yes	0	7	8
61	R:R:A157	R:R:R154	13.576	5.53	No	No	0	8	9
62	R:R:I246	R:R:Y243	11.2249	2.42	No	Yes	0	8	8
63	R:R:L185	R:R:L189	47.6868	2.77	No	No	0	4	5
64	R:R:L189	R:R:Q227	38.7435	2.66	No	Yes	0	5	5
65	R:R:P192	R:R:Q227	10.201	4.74	No	Yes	0	8	5
66	R:R:Q224	R:R:Q227	23.777	8.96	No	Yes	0	5	5
67	R:R:F220	R:R:Q224	14.0185	15.23	Yes	No	5	4	5
68	R:R:F232	R:R:L233	15.5417	3.65	Yes	No	0	8	4
69	R:R:A157	R:R:I158	11.3323	1.62	No	Yes	0	8	8
70	R:R:I158	R:R:L250	13.0514	2.85	Yes	No	0	8	8
71	R:R:I262	W:W:?1	26.8171	4.08	Yes	Yes	0	5	0
72	R:R:I262	R:R:R258	14.3029	1.25	Yes	No	0	5	6
73	R:R:I158	R:R:R258	10.517	1.25	Yes	No	0	8	6
74	R:R:F275	R:R:R318	11.5599	8.55	Yes	Yes	0	7	9
75	R:R:T311	R:R:Y279	15.9967	3.75	Yes	Yes	0	6	6
76	R:R:Y279	R:R:Y308	17.3556	6.95	Yes	No	0	6	4
77	R:R:M239	R:R:Y243	20.6421	3.59	Yes	Yes	3	7	8
78	R:R:C319	R:R:R318	18.784	5.57	Yes	Yes	1	8	9
79	R:R:Y279	R:R:Y312	39.5462	12.91	Yes	Yes	0	6	5
80	R:R:P235	R:R:W145	35.0841	16.21	No	Yes	1	9	5
81	R:R:Y312	R:R:Y65	17.0459	6.95	Yes	Yes	0	5	7
82	R:R:F272	R:R:Q276	33.0932	4.68	Yes	Yes	1	9	8
83	R:R:N280	R:R:Y279	19.4602	5.81	Yes	Yes	1	8	6
84	R:R:F140	R:R:M144	20.6485	4.98	Yes	Yes	1	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
I:I:?1	R:R:Y326	4.64	1	Yes	Yes	0	9	2	1
R:R:V79	R:R:Y326	5.05	0	No	Yes	9	9	2	1
R:R:F333	R:R:T82	7.78	1	Yes	No	8	6	1	1
R:R:L337	R:R:T82	4.42	1	No	No	6	6	2	1
R:R:T82	W:W:?1	4.21	1	No	Yes	6	0	1	0
R:R:F86	R:R:L89	3.65	0	No	No	5	7	2	2
R:R:D336	R:R:F86	21.5	1	Yes	No	5	5	1	2
R:R:K332	R:R:L89	4.23	1	Yes	No	7	7	1	2
R:R:T91	R:R:T93	4.71	1	No	Yes	7	7	1	1
R:R:D94	R:R:T91	13.01	1	No	No	8	7	1	1
R:R:T91	W:W:?1	14.33	1	No	Yes	7	0	1	0
R:R:I150	R:R:T93	4.56	0	No	Yes	8	7	2	1
R:R:D153	R:R:T93	7.23	0	No	Yes	8	7	2	1
R:R:T93	W:W:?1	15.17	1	Yes	Yes	7	0	1	0
R:R:D94	R:R:K332	8.3	1	No	Yes	8	7	1	1
R:R:D94	W:W:?1	25.61	1	No	Yes	8	0	1	0
R:R:L97	R:R:Y326	11.72	1	No	Yes	7	9	1	1
R:R:L97	W:W:?1	7.91	1	No	Yes	7	0	1	0
R:R:D153	R:R:R154	15.48	0	No	No	8	9	2	1
R:R:A157	R:R:R154	5.53	0	No	No	8	9	2	1
R:R:R154	W:W:?1	11.81	0	No	Yes	9	0	1	0
R:R:I262	R:R:V264	7.68	0	Yes	No	5	7	1	2
R:R:I262	W:W:?1	4.08	0	Yes	Yes	5	0	1	0
R:R:F333	R:R:Y326	4.13	1	Yes	Yes	8	9	1	1
R:R:Y326	W:W:?1	6.03	1	Yes	Yes	9	0	1	0
R:R:D336	R:R:K332	11.06	1	Yes	Yes	5	7	1	1
R:R:K332	W:W:?1	22.57	1	Yes	Yes	7	0	1	0
R:R:F333	R:R:L337	4.87	1	Yes	No	8	6	1	2
R:R:F333	W:W:?1	4.18	1	Yes	Yes	8	0	1	0
R:R:D336	W:W:?1	4.66	1	Yes	Yes	5	0	1	0
R:R:I262	R:R:V331	3.07	0	Yes	No	5	5	1	2
R:R:A327	R:R:F333	2.77	0	No	Yes	7	8	2	1
R:R:D336	R:R:K339	2.77	1	Yes	No	5	4	1	2
R:R:I262	R:R:R258	1.25	0	Yes	No	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
53.33	Single	6LFL	PubChem 153466996	6LFL-CXCR2-PubChem 153466996
47.06	Single	5LWE	Vercirnon	5LWE-CCR9-Vercirnon
35.71	Single	5T1A	PubChem 12093170	5T1A-CCR2-BMS-681-PubChem 12093170
23.53	Single	5X7D	Cmpd-15	5X7D-β₂-S-Carazolol-Cmpd-15
22.22	Single	3VG9	Antibody	3VG9-A_2A-ZM-241385-Antibody
21.74	Single	8FN0	SBI-553	8FN0-NTS₁-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
21.74	Single	8ZYT	SBI-553	8ZYT-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
20.00	Single	3VGA	Antibody	3VGA-A_2A-ZM-241385-Antibody
20.00	Single	8JPB	SBI-553; GDP; Mg	8JPB-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
19.05	Single	8ZYU	SBI-553	8ZYU-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
19.05	Single	8ZYY	SBI-553	8ZYY-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
15.79	Single	8JPC	SBI-553; GDP; Mg	8JPC-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
15.79	Single	8JPF	SBI-553	8JPF-NTS₁-Neurotensin-SBI-553
15.00	Single	8GW8	PCO371	8GW8-PTH1-PCO371-Gs/β1/γ2
13.64	Single	8JR9	PCO371	8JR9-PTH1-PCO371-chim(NtGi1-Gs)/β1/γ2
10.00	Single	8XQL	Aristolochic acid A	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
9.09	Single	8J20	AR420626	8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
8.70	Single	8TB7	PubChem 168510218	8TB7-GPR61-PubChem 168510218
8.33	Single	7EVM	PubChem 156022738	7EVM-GLP-1-PubChem 156022738-Gs/β1/γ2
7.14	Single	4PXF	Octyl-Beta-D-Glucopyranoside	4PXF-Rhodopsin-Octyl-β-D-Glucopyranoside-Arrestin1 Finger Loop
7.14	Single	7DUQ	PubChem 156022738	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
5.88	Single	8XQP	Aristolochic acid A	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.26	Single	7EJX	(1R;2R)-2-PCCA	7EJX-GPR88-(1R;2R)-2-PCCA-Gi1/β1/γ2
5.26	Single	8XQN	Aristolochic acid A	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
5.26	Single	8XQR	Flufenamic acid	8XQR-TAS2R14-Flufenamic acid-Gt3/β1/γ1
5.00	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
5.00	Single	8XQO	Aristolochic acid A	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
5.00	Single	8XQS	Flufenamic acid	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
4.76	Single	5XF1	NNC0640	5XF1-Glucagon-NNC0640

PDB Summary
PDB	6QZH
Class	A
SubFamily	Protein
Type	Chemokine
SubType	CCR7
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	Cmp2105; Na
Protein Partners	-
PDB Resolution	2.1
Date	2019-09-04
D.O.I.	doi.org/10.1016/j.cell.2019.07.028

Net Summary
I_min	3.5
Number of Linked Nodes	255
Number of Links	289
Number of Hubs	48
Number of Links mediated by Hubs	168
Number of Communities	5
Number of Nodes involved in Communities	51
Number of Links involved in Communities	75

Path Summary
Number Of Nodes in MetaPath	85
Number Of Links MetaPath	84
Number of Shortest Paths	46405
Length Of Smallest Path	3
Average Path Length	11.3318
Length of Longest Path	23
Minimum Path Strength	1.245
Average Path Strength	6.71923
Maximum Path Strength	18.87
Minimum Path Correlation	0.7
Average Path Correlation	0.926911
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	58.6039
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	58.8966
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• chemokine (C-C motif) ligand 21 binding • C-C chemokine binding • protein binding • binding • chemokine binding • cytokine binding • G protein-coupled chemoattractant receptor activity • C-C motif chemokine 19 receptor activity • C-C chemokine receptor activity • molecular transducer activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cytokine receptor activity • immune receptor activity • chemokine (C-C motif) ligand 19 binding • C-C motif chemokine 21 receptor activity • hydrolase activity, acting on glycosyl bonds • alpha-sialidase activity • hydrolase activity, hydrolyzing O-glycosyl compounds • hydrolase activity • exo-alpha-sialidase activity • catalytic activity • developmental process • myeloid leukocyte differentiation • cellular developmental process • hemopoiesis • cell development • mononuclear cell differentiation • myeloid cell differentiation • cell differentiation • anatomical structure development • dendritic cell differentiation • cellular process • mature conventional dendritic cell differentiation • leukocyte differentiation • cellular response to stimulus
Gene Ontology	Biological Process	• developmental process • myeloid leukocyte differentiation • cellular developmental process • hemopoiesis • cell development • mononuclear cell differentiation • myeloid cell differentiation • cell differentiation • anatomical structure development • dendritic cell differentiation • cellular process • mature conventional dendritic cell differentiation • leukocyte differentiation • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • cell surface receptor signaling pathway • signaling • CCL19-activated CCR7 signaling pathway • biological regulation • response to cytokine • response to chemokine • chemokine (C-C motif) ligand 19 signaling pathway • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • cell communication • response to peptide • response to chemical • G protein-coupled receptor signaling pathway • cellular response to cytokine stimulus • signal transduction • C-C chemokine receptor CCR7 signaling pathway • thymic T cell selection • multicellular organismal process • cell activation • lymphocyte activation • lymphocyte differentiation • leukocyte activation • T cell differentiation in thymus • T cell activation • immune system process • negative thymic T cell selection • T cell differentiation • negative T cell selection • T cell selection • regulation of cellular component organization • positive regulation of cellular component organization • cell projection organization • positive regulation of biological process • plasma membrane bounded cell projection assembly • cellular component biogenesis • cellular component organization • pseudopodium assembly • cellular component assembly • positive regulation of cell projection organization • cellular component organization or biogenesis • positive regulation of cellular process • plasma membrane bounded cell projection organization • positive regulation of cellular component biogenesis • regulation of cell projection organization • regulation of cell projection assembly • regulation of cellular component biogenesis • regulation of plasma membrane bounded cell projection assembly • positive regulation of pseudopodium assembly • regulation of pseudopodium assembly • cell projection assembly • regulation of plasma membrane bounded cell projection organization • positive regulation of plasma membrane bounded cell projection assembly • pseudopodium organization • regulation of cell-substrate adhesion • positive regulation of cell adhesion • regulation of cell adhesion • cell-substrate adhesion • positive regulation of cell-matrix adhesion • cell adhesion • cell-matrix adhesion • positive regulation of cell-substrate adhesion • regulation of cell-matrix adhesion • cell chemotaxis • chemotaxis • dendritic cell chemotaxis • response to external stimulus • leukocyte migration • dendritic cell migration • myeloid dendritic cell chemotaxis • cellular response to chemical stimulus • taxis • mononuclear cell migration • myeloid leukocyte migration • cell migration • cell motility • leukocyte chemotaxis • locomotion • regulation of biosynthetic process • regulation of type II interferon production • type II interferon production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • cytokine production • regulation of cytokine production • metabolic process • regulation of macromolecule biosynthetic process • regulation of multicellular organismal process • macromolecule metabolic process • regulation of metabolic process • regulation of humoral immune response • humoral immune response • immune response • positive regulation of response to stimulus • positive regulation of humoral immune response • regulation of response to stimulus • positive regulation of immune response • regulation of immune response • regulation of immune system process • positive regulation of immune system process • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • positive regulation of cell communication • immune response-regulating cell surface receptor signaling pathway • positive regulation of signal transduction • positive regulation of T cell receptor signaling pathway • regulation of antigen receptor-mediated signaling pathway • regulation of signal transduction • immune response-activating signaling pathway • immune response-regulating signaling pathway • regulation of signaling • immune response-activating cell surface receptor signaling pathway • regulation of T cell receptor signaling pathway • T cell receptor signaling pathway • regulation of cell communication • antigen receptor-mediated signaling pathway • activation of immune response • positive regulation of antigen receptor-mediated signaling pathway • positive regulation of signaling • intracellular signal transduction • positive regulation of JNK cascade • regulation of intracellular signal transduction • JNK cascade • intracellular signaling cassette • positive regulation of MAPK cascade • regulation of JNK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • CCL21-activated CCR7 signaling pathway • chemokine (C-C motif) ligand 21 signaling pathway • regulation of localization • import into cell • transport • vesicle-mediated transport • localization • positive regulation of endocytosis • positive regulation of receptor-mediated endocytosis • regulation of endocytosis • regulation of transport • regulation of receptor-mediated endocytosis • regulation of vesicle-mediated transport • establishment of localization • positive regulation of transport • endocytosis • receptor-mediated endocytosis • lymphocyte migration into lymphoid organs • lymphocyte migration • lymphocyte migration into lymph node • ruffle organization • phospholipase C/protein kinase C signal transduction • positive regulation of phospholipase C/protein kinase C signal transduction • positive regulation of locomotion • regulation of cell motility • regulation of locomotion • positive regulation of cell motility • regulation of leukocyte activation • regulation of cell activation • positive regulation of leukocyte cell-cell adhesion • positive regulation of T cell costimulation • leukocyte cell-cell adhesion • positive regulation of cell-cell adhesion • positive regulation of lymphocyte activation • positive regulation of cell activation • cell-cell adhesion • positive regulation of leukocyte activation • regulation of cell-cell adhesion • positive regulation of T cell activation • regulation of T cell costimulation • regulation of T cell activation • lymphocyte costimulation • regulation of leukocyte cell-cell adhesion • positive regulation of multicellular organismal process • T cell costimulation • regulation of lymphocyte activation • regulation of interleukin-1 production • interleukin-1 production • regulation of interleukin-1 beta production • interleukin-1 beta production • response to nitric oxide • response to nitrogen compound • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • Rac protein signal transduction • regulation of Rac protein signal transduction • positive regulation of Rac protein signal transduction • positive regulation of small GTPase mediated signal transduction • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • positive regulation of canonical NF-kappaB signal transduction • canonical NF-kappaB signal transduction • regulation of canonical NF-kappaB signal transduction • multicellular organismal-level homeostasis • homeostatic process • homeostasis of number of cells • positive regulation of ERK1 and ERK2 cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of dendritic cell chemotaxis • regulation of response to external stimulus • positive regulation of chemotaxis • positive regulation of cell migration • positive regulation of response to external stimulus • regulation of cell migration • positive regulation of mononuclear cell migration • regulation of mononuclear cell migration • regulation of dendritic cell chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • regulation of chemotaxis • regulation of Cdc42 protein signal transduction • regulation of Rho protein signal transduction • Rho protein signal transduction • Cdc42 protein signal transduction • immunological synapse formation • positive regulation of glycoprotein metabolic process • positive regulation of protein metabolic process • carbohydrate derivative metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation • positive regulation of metabolic process • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • cell recognition • protein metabolic process • regulation of glycoprotein biosynthetic process • positive regulation of glycoprotein biosynthetic process • carbohydrate derivative biosynthetic process • cell-cell recognition • regulation of protein metabolic process • glycoprotein biosynthetic process • primary metabolic process • glycoprotein metabolic process • regulation of glycoprotein metabolic process • positive regulation of acute inflammatory response to antigenic stimulus • regulation of defense response • regulation of acute inflammatory response to antigenic stimulus • positive regulation of acute inflammatory response • inflammatory response to antigenic stimulus • positive regulation of hypersensitivity • positive regulation of inflammatory response • response to stress • regulation of response to stress • acute inflammatory response • hypersensitivity • regulation of hypersensitivity • defense response • regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • acute inflammatory response to antigenic stimulus • positive regulation of inflammatory response to antigenic stimulus • positive regulation of defense response • regulation of acute inflammatory response • inflammatory response • regulation of interleukin-12 production • interleukin-12 production • positive regulation of interleukin-12 production • positive regulation of gene expression • positive regulation of cytokine production • positive regulation of neutrophil chemotaxis • neutrophil migration • granulocyte migration • positive regulation of granulocyte chemotaxis • regulation of neutrophil chemotaxis • regulation of neutrophil migration • neutrophil chemotaxis • regulation of granulocyte chemotaxis • positive regulation of neutrophil migration • granulocyte chemotaxis • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • calcium-mediated signaling • regulation of dendritic cell dendrite assembly • dendritic cell dendrite assembly • regulation of leukocyte apoptotic process • dendritic cell apoptotic process • negative regulation of dendritic cell apoptotic process • negative regulation of programmed cell death • leukocyte apoptotic process • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of leukocyte apoptotic process • negative regulation of cellular process • regulation of dendritic cell apoptotic process • apoptotic process • programmed cell death • positive regulation of immunological synapse formation • regulation of immunological synapse formation • positive regulation of organelle organization • regulation of cytoskeleton organization • regulation of actin filament-based process • regulation of cellular component size • regulation of protein-containing complex assembly • positive regulation of protein-containing complex assembly • positive regulation of protein polymerization • protein-containing complex assembly • actin filament-based process • regulation of actin filament polymerization • protein polymerization • actin polymerization or depolymerization • regulation of actin filament organization • actin cytoskeleton organization • actin filament polymerization • protein-containing complex organization • positive regulation of cytoskeleton organization • regulation of actin polymerization or depolymerization • actin filament organization • positive regulation of supramolecular fiber organization • regulation of organelle organization • organelle organization • regulation of protein polymerization • regulation of actin filament length • regulation of actin cytoskeleton organization • regulation of supramolecular fiber organization • supramolecular fiber organization • positive regulation of actin filament polymerization • cytoskeleton organization • regulation of anatomical structure size • cellular localization • inorganic ion homeostasis • intracellular calcium ion homeostasis • monoatomic ion transmembrane transport • calcium ion homeostasis • negative regulation of sequestering of calcium ion • calcium ion transport • metal ion transport • maintenance of location in cell • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • monoatomic ion transport • intracellular chemical homeostasis • monoatomic cation homeostasis • monoatomic cation transport • regulation of sequestering of calcium ion • intracellular monoatomic ion homeostasis • calcium ion transmembrane import into cytosol • sequestering of calcium ion • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • cellular homeostasis • chemical homeostasis • calcium ion transmembrane transport • filopodium assembly • regulation of filopodium assembly • positive regulation of filopodium assembly • establishment of lymphocyte polarity • establishment of T cell polarity • establishment or maintenance of cell polarity • establishment of cell polarity • negative regulation of interleukin-12 production • negative regulation of macromolecule metabolic process • negative regulation of metabolic process • negative regulation of cytokine production • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of multicellular organismal process • regulation of dendritic cell antigen processing and presentation • positive regulation of dendritic cell antigen processing and presentation • positive regulation of antigen processing and presentation • antigen processing and presentation • regulation of antigen processing and presentation • dendritic cell antigen processing and presentation • biological process involved in interspecies interaction between organisms • response to other organism • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • carbohydrate metabolic process • catabolic process • oligosaccharide catabolic process • oligosaccharide metabolic process • carbohydrate catabolic process • membrane lipid metabolic process • sphingolipid catabolic process • ceramide metabolic process • ganglioside catabolic process • carbohydrate derivative catabolic process • glycosphingolipid catabolic process • lipid catabolic process • glycolipid metabolic process • glycosphingolipid metabolic process • liposaccharide metabolic process • sphingolipid metabolic process • membrane lipid catabolic process • glycolipid catabolic process • ceramide catabolic process • amide metabolic process • ganglioside metabolic process • lipid metabolic process • cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • mitochondrion • organelle • cytoplasm • intracellular membrane-bounded organelle
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • mitochondrion • organelle • cytoplasm • intracellular membrane-bounded organelle • extracellular region
SCOP2	Domain Identifier	• Sialidases
SCOP2	Family Identifier	• Sialidases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NA
PDB Residues	I:I:?1
Environment Details	Open EMBL-EBI Page
Code	NA
Name	SODIUM ION
Synonyms
Identifier
Formula	Na
Molecular Weight	22.99
SMILES
PubChem
Formal Charge	1
Total Atoms	1
Total Chiral Atoms	0
Total Bonds	0
Total Aromatic Bonds	0


Code	JLW
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	JLW
Name	3-[[4-[[(1~{R})-2,2-dimethyl-1-(5-methylfuran-2-yl)propyl]amino]-1,1-bis(oxidanylidene)-1,2,5-thiadiazol-3-yl]amino]-~{N},~{N},6-trimethyl-2-oxidanyl-benzamide
Synonyms
Identifier
Formula	C22 H29 N5 O5 S
Molecular Weight	475.561
SMILES
PubChem	136165388
Formal Charge	0
Total Atoms	62
Total Chiral Atoms	1
Total Bonds	64
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32248
Sequence	>6QZH_Chain_R D V R N F K A W F L P I M Y S I I C F V G L L G N G L V V L T Y I Y F K R L K T M T D T Y L L N L A V A D I L F L L T L P F W A Y S A A K S W V F G V H F C K L I F A I Y K M S F F S G M W L L L C I S I D R Y V A I V H R H R A R V L L I S K L S C V G I W I L A T V L S I P E L L Y S D L Q R S S S E Q A M R C S L I T E H V E A F I T I Q V A Q M V I G F L V P L L A M S F C Y L V I I S K L H G H E R N I K V I I A V V V V F I V F Q L P Y N G V V L A Q T V T C E L S K Q L N I A Y D V T Y S L A C V R C C V N P F L Y A F I G V K F R N D L F K L F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6QZH	A	Protein	Chemokine	CCR7	Homo sapiens	-	Cmp2105; Na	-	2.1	2019-09-04	doi.org/10.1016/j.cell.2019.07.028

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