psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N55	R:R:R54	7.23	No	No	0	5	4
2	R:R:F56	R:R:R54	4.28	No	No	0	4	4
3	R:R:F56	R:R:W59	6.01	No	No	0	4	1
4	R:R:F60	R:R:L61	7.31	No	No	0	5	6
5	R:R:F60	R:R:M64	8.71	No	Yes	0	5	5
6	R:R:L61	R:R:Y65	11.72	No	Yes	0	6	7
7	R:R:M64	R:R:Y65	4.79	Yes	Yes	0	5	7
8	R:R:M64	R:R:S313	6.13	Yes	No	0	5	5
9	R:R:L111	R:R:Y65	11.72	Yes	Yes	0	8	7
10	R:R:Y312	R:R:Y65	6.95	Yes	Yes	0	5	7
11	R:R:C69	R:R:L111	4.76	No	Yes	0	6	8
12	R:R:C320	R:R:V71	6.83	No	No	0	7	5
13	R:R:F324	R:R:V71	3.93	No	No	0	6	5
14	R:R:C320	R:R:G72	3.92	No	No	0	7	8
15	R:R:I105	R:R:L73	4.28	No	No	0	7	5
16	R:R:L109	R:R:L73	4.15	No	No	0	4	5
17	R:R:G75	R:R:P323	4.06	No	No	0	7	9
18	R:R:D104	R:R:N76	10.77	Yes	No	1	9	9
19	R:R:N76	R:R:P323	9.77	No	No	1	9	9
20	I:I:?1	R:R:N76	8.15	Yes	No	1	0	9
21	R:R:L337	R:R:L78	5.54	Yes	No	0	6	6
22	R:R:V79	R:R:Y326	5.05	No	Yes	0	9	9
23	R:R:F333	R:R:T82	7.78	Yes	No	1	8	6
24	R:R:L337	R:R:T82	4.42	Yes	No	1	6	6
25	R:R:T82	W:W:?1	4.21	No	Yes	1	6	0
26	R:R:K87	R:R:Y83	17.91	No	Yes	3	6	7
27	R:R:K90	R:R:Y83	5.97	No	Yes	3	6	7
28	R:R:T95	R:R:Y83	6.24	No	Yes	0	5	7
29	R:R:L98	R:R:Y83	16.41	No	Yes	0	6	7
30	R:R:F86	R:R:L89	3.65	No	No	0	5	7
31	R:R:D336	R:R:F86	21.5	No	No	0	5	5
32	R:R:F86	R:R:L340	3.65	No	No	0	5	5
33	R:R:K87	R:R:K90	24.42	No	No	3	6	6
34	R:R:K332	R:R:L89	4.23	Yes	No	0	7	7
35	R:R:T91	R:R:T93	4.71	No	Yes	1	7	7
36	R:R:D94	R:R:T91	13.01	No	No	1	8	7
37	R:R:T91	W:W:?1	14.33	No	Yes	1	7	0
38	R:R:M92	R:R:Y96	7.18	Yes	Yes	0	6	7
39	R:R:D153	R:R:M92	9.7	No	Yes	0	8	6
40	R:R:M92	R:R:S175	4.6	Yes	No	0	6	8
41	R:R:I150	R:R:T93	4.56	No	Yes	0	8	7
42	R:R:D153	R:R:T93	7.23	No	Yes	0	8	7
43	R:R:T93	W:W:?1	15.17	Yes	Yes	1	7	0
44	R:R:D94	R:R:K332	8.3	No	Yes	1	8	7
45	R:R:D94	W:W:?1	25.61	No	Yes	1	8	0
46	R:R:C149	R:R:Y96	13.44	No	Yes	0	6	7
47	R:R:I150	R:R:Y96	6.04	No	Yes	0	8	7
48	R:R:S178	R:R:Y96	5.09	No	Yes	0	5	7
49	R:R:L97	R:R:Y326	11.72	No	Yes	1	7	9
50	R:R:L97	W:W:?1	7.91	No	Yes	1	7	0
51	R:R:C179	R:R:N99	11.02	No	No	0	7	9
52	R:R:N99	R:R:W183	7.91	No	Yes	0	9	9
53	R:R:D104	R:R:L100	4.07	Yes	No	0	9	9
54	R:R:L100	R:R:L146	4.15	No	No	0	9	8
55	R:R:V102	R:R:W183	3.68	No	Yes	0	5	9
56	R:R:A103	R:R:W183	3.89	No	Yes	0	8	9
57	R:R:D104	R:R:R318	10.72	Yes	Yes	1	9	9
58	R:R:C319	R:R:D104	10.89	Yes	Yes	1	8	9
59	R:R:D104	R:R:N322	4.04	Yes	Yes	1	9	9
60	I:I:?1	R:R:D104	8.05	Yes	Yes	1	0	9
61	R:R:F107	R:R:L111	3.65	Yes	Yes	1	6	8
62	R:R:F107	R:R:Y136	11.35	Yes	Yes	1	6	6
63	R:R:F107	R:R:S139	5.28	Yes	No	0	6	8
64	R:R:C316	R:R:F107	5.59	Yes	Yes	1	7	6
65	R:R:C319	R:R:F107	4.19	Yes	Yes	1	8	6
66	R:R:C319	R:R:L108	4.76	Yes	No	0	8	5
67	R:R:I132	R:R:T110	6.08	No	No	0	5	6
68	R:R:C316	R:R:L111	6.35	Yes	Yes	1	7	8
69	R:R:F113	R:R:F124	9.65	No	Yes	0	6	7
70	R:R:F113	R:R:F128	13.93	No	No	0	6	5
71	R:R:W114	R:R:W122	5.62	Yes	Yes	0	6	9
72	R:R:I132	R:R:W114	10.57	No	Yes	0	5	6
73	R:R:F133	R:R:W114	4.01	No	Yes	0	5	6
74	R:R:W114	R:R:Y312	5.79	Yes	Yes	0	6	5
75	R:R:V123	R:R:Y116	6.31	No	No	2	2	3
76	R:R:F124	R:R:Y116	8.25	Yes	No	2	7	3
77	R:R:S117	R:R:W122	7.41	No	Yes	0	5	9
78	R:R:R209	R:R:S117	9.22	No	No	0	4	5
79	R:R:F124	R:R:W122	14.03	Yes	Yes	2	7	9
80	R:R:C129	R:R:W122	3.92	No	Yes	2	9	9
81	R:R:L199	R:R:W122	6.83	No	Yes	0	4	9
82	R:R:C210	R:R:W122	20.89	No	Yes	2	9	9
83	R:R:F124	R:R:V123	7.87	Yes	No	2	7	2
84	R:R:L199	R:R:V126	5.96	No	No	0	4	2
85	R:R:F128	R:R:L131	3.65	No	No	0	5	4
86	R:R:F128	R:R:I132	7.54	No	No	0	5	5
87	R:R:C129	R:R:C210	7.28	No	No	2	9	9
88	R:R:F133	R:R:S197	13.21	No	No	0	5	5
89	R:R:F133	R:R:L212	9.74	No	No	0	5	5
90	R:R:I135	R:R:M138	5.83	No	Yes	0	4	5
91	R:R:K137	R:R:Y136	4.78	Yes	Yes	1	5	6
92	R:R:Q276	R:R:Y136	13.53	Yes	Yes	1	8	6
93	R:R:Y136	R:R:Y279	8.94	Yes	Yes	1	6	6
94	R:R:N280	R:R:Y136	10.47	Yes	Yes	1	8	6
95	R:R:F141	R:R:K137	3.72	No	Yes	0	7	5
96	R:R:E193	R:R:K137	10.8	No	Yes	0	4	5
97	R:R:K137	R:R:N280	6.99	Yes	Yes	1	5	8
98	R:R:M138	R:R:T187	6.02	Yes	No	0	5	3
99	R:R:M138	R:R:S190	6.13	Yes	No	0	5	7
100	R:R:F140	R:R:F141	9.65	Yes	No	0	7	7
101	R:R:F140	R:R:M144	4.98	Yes	Yes	1	7	7
102	R:R:F140	R:R:F232	10.72	Yes	Yes	1	7	8
103	R:R:F140	R:R:Q276	12.88	Yes	Yes	1	7	8
104	R:R:F140	R:R:N280	12.08	Yes	Yes	1	7	8
105	R:R:F141	R:R:G231	9.03	No	No	0	7	5
106	R:R:G143	R:R:S142	3.71	No	No	0	9	6
107	R:R:S142	R:R:W183	8.65	No	Yes	0	6	9
108	R:R:F272	R:R:G143	4.52	Yes	No	0	9	9
109	R:R:F232	R:R:M144	8.71	Yes	Yes	1	8	7
110	R:R:M144	R:R:P235	6.71	Yes	No	0	7	9
111	R:R:F272	R:R:M144	6.22	Yes	Yes	1	9	7
112	R:R:I182	R:R:W145	4.7	No	Yes	0	6	5
113	R:R:L185	R:R:W145	9.11	No	Yes	0	4	5
114	R:R:V234	R:R:W145	4.9	No	Yes	0	5	5
115	R:R:P235	R:R:W145	16.21	No	Yes	0	9	5
116	R:R:I182	R:R:L146	5.71	No	No	0	6	8
117	R:R:L147	R:R:V269	7.45	No	No	0	8	7
118	R:R:F272	R:R:L147	3.65	Yes	No	0	9	8
119	R:R:L148	R:R:S151	4.5	Yes	Yes	4	7	9
120	R:R:I152	R:R:L148	4.28	No	Yes	0	5	7
121	R:R:A238	R:R:L148	4.73	No	Yes	0	7	7
122	R:R:L148	R:R:M239	7.07	Yes	No	4	7	7
123	R:R:I150	R:R:I265	8.83	No	No	0	8	7
124	R:R:M239	R:R:S151	6.13	No	Yes	4	7	9
125	R:R:S151	R:R:Y243	10.17	Yes	Yes	0	9	8
126	R:R:D153	R:R:R154	15.48	No	No	0	8	9
127	R:R:A157	R:R:R154	5.53	No	No	0	8	9
128	R:R:R154	W:W:?1	11.81	No	Yes	0	9	0
129	R:R:V159	R:R:Y155	6.31	No	Yes	0	7	8
130	R:R:F241	R:R:Y155	7.22	No	Yes	0	3	8
131	R:R:C242	R:R:Y155	4.03	No	Yes	0	7	8
132	R:R:R168	R:R:V171	3.92	No	No	0	7	6
133	R:R:C179	R:R:K176	6.47	No	No	0	7	3
134	R:R:I191	R:R:L194	4.28	No	No	0	4	4
135	R:R:P192	R:R:Q227	4.74	No	Yes	0	8	5
136	R:R:I213	R:R:Y196	4.84	No	No	0	4	4
137	R:R:F220	R:R:Y196	6.19	Yes	No	5	4	4
138	R:R:Q224	R:R:Y196	4.51	No	No	5	5	4
139	R:R:D198	R:R:I213	4.2	No	No	0	4	4
140	R:R:Q200	R:R:S211	4.33	No	No	0	3	4
141	R:R:S202	R:R:S204	6.52	No	No	0	1	6
142	R:R:E205	R:R:Q206	7.65	No	No	0	4	5
143	R:R:I213	R:R:V217	7.68	No	No	0	4	2
144	R:R:E218	R:R:I221	5.47	No	No	0	1	2
145	R:R:F220	R:R:I221	11.3	Yes	No	0	4	2
146	R:R:F220	R:R:Q224	15.23	Yes	No	5	4	5
147	R:R:F220	R:R:T287	11.67	Yes	No	0	4	4
148	R:R:I223	R:R:T222	4.56	No	No	0	4	1
149	R:R:I223	R:R:Q227	4.12	No	Yes	0	4	5
150	R:R:Q224	R:R:Q227	8.96	No	Yes	0	5	5
151	R:R:F232	R:R:L233	3.65	Yes	No	0	8	4
152	R:R:F232	R:R:L236	8.53	Yes	No	0	8	6
153	R:R:M239	R:R:V269	4.56	No	No	0	7	7
154	R:R:F241	R:R:V245	3.93	No	No	0	3	3
155	R:R:I265	R:R:Y243	4.84	No	Yes	0	7	8
156	R:R:E257	R:R:N259	15.77	No	No	0	5	5
157	R:R:I262	R:R:V264	7.68	Yes	No	0	5	7
158	R:R:I262	W:W:?1	4.08	Yes	Yes	0	5	0
159	R:R:I266	R:R:K263	4.36	No	No	0	4	5
160	R:R:I329	R:R:V264	10.75	No	No	0	6	7
161	R:R:G330	R:R:V264	3.68	No	No	0	8	7
162	R:R:N322	R:R:V268	10.35	Yes	No	0	9	8
163	R:R:L325	R:R:V268	4.47	No	No	0	7	8
164	R:R:F275	R:R:V271	7.87	Yes	No	0	7	6
165	R:R:F272	R:R:Q276	4.68	Yes	Yes	1	9	8
166	R:R:F272	R:R:R318	13.9	Yes	Yes	1	9	9
167	R:R:F275	R:R:V274	5.24	Yes	No	0	7	5
168	R:R:F275	R:R:L314	3.65	Yes	No	0	7	7
169	R:R:F275	R:R:V317	3.93	Yes	No	0	7	5
170	R:R:F275	R:R:R318	8.55	Yes	Yes	0	7	9
171	R:R:Q276	R:R:R318	8.18	Yes	Yes	1	8	9
172	R:R:N280	R:R:Y279	5.81	Yes	Yes	1	8	6
173	R:R:V283	R:R:Y279	8.83	No	Yes	0	5	6
174	R:R:Y279	R:R:Y308	6.95	Yes	No	0	6	4
175	R:R:T311	R:R:Y279	3.75	Yes	Yes	0	6	6
176	R:R:Y279	R:R:Y312	12.91	Yes	Yes	0	6	5
177	R:R:T311	R:R:V282	6.35	Yes	No	0	6	5
178	R:R:L304	R:R:Q286	3.99	No	No	0	6	5
179	R:R:I306	R:R:K302	4.36	No	No	0	2	3
180	R:R:C316	R:R:Y312	5.38	Yes	Yes	0	7	5
181	R:R:C319	R:R:R318	5.57	Yes	Yes	1	8	9
182	R:R:N322	R:R:R318	4.82	Yes	Yes	1	9	9
183	I:I:?1	R:R:N322	8.15	Yes	Yes	1	0	9
184	I:I:?1	R:R:P323	6.5	Yes	No	1	0	9
185	R:R:F333	R:R:Y326	4.13	Yes	Yes	1	8	9
186	R:R:Y326	W:W:?1	6.03	Yes	Yes	1	9	0
187	I:I:?1	R:R:Y326	4.64	Yes	Yes	1	0	9
188	R:R:F328	R:R:I329	6.28	No	No	0	7	6
189	R:R:D336	R:R:K332	11.06	No	Yes	1	5	7
190	R:R:K332	W:W:?1	22.57	Yes	Yes	1	7	0
191	R:R:F333	R:R:L337	7.31	Yes	Yes	1	8	6
192	R:R:F333	W:W:?1	4.18	Yes	Yes	1	8	0
193	R:R:K339	R:R:N335	12.59	No	No	0	4	5
194	R:R:D336	W:W:?1	4.66	No	Yes	1	5	0
195	R:R:L337	R:R:L340	4.15	Yes	No	0	6	5
196	R:R:K120	R:R:Y116	3.58	No	No	0	4	3
197	R:R:I63	R:R:W59	3.52	No	No	0	5	1
198	R:R:P278	R:R:T311	3.5	No	Yes	0	9	6
199	R:R:C242	R:R:S151	3.44	No	Yes	0	7	9
200	R:R:G72	R:R:L108	3.42	No	No	0	8	5
201	R:R:A101	R:R:V79	3.39	No	No	0	9	9
202	R:R:H165	R:R:R166	3.39	No	No	0	5	4
203	R:R:I191	R:R:P192	3.39	No	No	0	4	8
204	R:R:H256	R:R:R258	3.39	No	No	0	3	6
205	R:R:A307	R:R:V282	3.39	No	No	0	5	5
206	R:R:Q286	R:R:Y308	3.38	No	No	0	5	4
207	R:R:C298	R:R:T297	3.38	No	No	0	5	5
208	R:R:L277	R:R:P278	3.28	No	No	0	5	9
209	R:R:C316	R:R:I68	3.27	Yes	No	0	7	6
210	R:R:C69	R:R:L73	3.17	No	No	0	6	5
211	R:R:A267	R:R:L325	3.15	No	No	0	5	7
212	R:R:I84	R:R:V80	3.07	No	No	0	2	7
213	R:R:I230	R:R:V229	3.07	No	No	0	4	4
214	R:R:I262	R:R:V331	3.07	Yes	No	0	5	5
215	R:R:K176	R:R:T95	3	No	No	0	3	5
216	R:R:L98	R:R:V80	2.98	No	No	0	6	7
217	R:R:L106	R:R:V102	2.98	No	No	0	6	5
218	R:R:L233	R:R:V229	2.98	No	No	0	4	4
219	R:R:L325	R:R:V321	2.98	No	No	0	7	6
220	R:R:I273	R:R:M144	2.92	No	Yes	0	5	7
221	R:R:I158	R:R:K249	2.91	Yes	No	0	8	5
222	R:R:I158	R:R:L250	2.85	Yes	No	0	8	8
223	R:R:K130	R:R:L194	2.82	No	No	0	7	4
224	R:R:K176	R:R:L172	2.82	No	No	0	3	2
225	R:R:G125	R:R:W122	2.81	No	Yes	0	7	9
226	R:R:H127	R:R:V126	2.77	No	No	0	1	2
227	R:R:L185	R:R:L189	2.77	No	No	0	4	5
228	R:R:L233	R:R:L237	2.77	No	No	0	4	4
229	R:R:A327	R:R:F333	2.77	No	Yes	0	7	8
230	R:R:L189	R:R:Q227	2.66	No	Yes	0	5	5
231	R:R:N305	R:R:Q286	2.64	No	No	0	4	5
232	R:R:V156	R:R:Y155	2.52	No	Yes	0	6	8
233	R:R:K57	R:R:R54	2.48	No	No	0	4	4
234	R:R:F70	R:R:L74	2.44	No	No	0	5	4
235	R:R:F220	R:R:L284	2.44	Yes	No	0	4	5
236	R:R:L173	R:R:R170	2.43	No	No	0	4	5
237	R:R:I246	R:R:Y155	2.42	No	Yes	0	8	8
238	R:R:I246	R:R:Y243	2.42	No	Yes	0	8	8
239	R:R:I266	R:R:Y243	2.42	No	Yes	0	4	8
240	R:R:M138	R:R:W183	2.33	Yes	Yes	0	5	9
241	R:R:D309	R:R:Y308	2.3	No	No	0	5	4
242	R:R:C69	R:R:P112	1.88	No	No	0	6	9
243	R:R:A115	R:R:P62	1.87	No	Yes	0	7	6
244	R:R:A118	R:R:P62	1.87	No	Yes	0	5	6
245	R:R:A119	R:R:P62	1.87	No	Yes	0	4	6
246	R:R:G181	R:R:I184	1.76	No	No	0	2	4
247	R:R:G75	R:R:L74	1.71	No	No	0	7	4
248	R:R:A207	R:R:S121	1.71	No	No	0	1	5
249	R:R:A186	R:R:S142	1.71	No	No	0	7	6
250	R:R:G281	R:R:L284	1.71	No	No	0	6	5
251	R:R:L61	R:R:P62	1.64	No	Yes	0	6	6
252	R:R:A157	R:R:I158	1.62	No	Yes	0	8	8
253	R:R:V225	R:R:V229	1.6	No	No	0	4	4
254	R:R:T311	R:R:V310	1.59	Yes	No	0	6	5
255	R:R:A134	R:R:L194	1.58	No	No	0	5	4
256	R:R:I67	R:R:V71	1.54	No	No	0	5	5
257	R:R:I184	R:R:V180	1.54	No	No	0	4	3
258	R:R:I184	R:R:V188	1.54	No	No	0	4	4
259	R:R:I266	R:R:V270	1.54	No	No	0	4	4
260	R:R:M92	R:R:V171	1.52	Yes	No	0	6	6
261	R:R:A315	R:R:Q276	1.52	No	Yes	0	8	8
262	R:R:C298	R:R:E299	1.52	No	No	0	5	5
263	R:R:L236	R:R:S240	1.5	No	No	0	6	4
264	R:R:L189	R:R:V188	1.49	No	No	0	5	4
265	R:R:I63	R:R:M64	1.46	No	Yes	0	5	5
266	R:R:I174	R:R:M92	1.46	No	Yes	0	3	6
267	R:R:Q200	R:R:T214	1.42	No	No	0	3	5
268	R:R:L199	R:R:M208	1.41	No	No	0	4	5
269	R:R:L284	R:R:M228	1.41	No	No	0	5	5
270	R:R:D309	R:R:I306	1.4	No	No	0	5	2
271	R:R:A327	R:R:R334	1.38	No	No	0	7	8
272	R:R:L250	R:R:N259	1.37	No	No	0	8	5
273	R:R:L300	R:R:Q303	1.33	No	No	0	3	3
274	R:R:R209	R:R:S121	1.32	No	No	0	4	5
275	R:R:R201	R:R:S203	1.32	No	No	0	1	2
276	R:R:D198	R:R:Q200	1.31	No	No	0	4	3
277	R:R:I158	R:R:R258	1.25	Yes	No	0	8	6
278	R:R:I262	R:R:R258	1.25	Yes	No	0	5	6
279	R:R:E215	R:R:H216	1.23	No	No	0	6	2
280	R:R:H167	R:R:R166	1.13	No	No	0	3	4
281	R:R:R168	R:R:R88	1.07	No	No	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P62	1.8125	4	0	6
2	R:R:M64	5.2725	4	0	5
3	R:R:Y65	8.795	4	0	7
4	R:R:Y83	11.6325	4	3	7
5	R:R:M92	4.892	5	0	6
6	R:R:T93	7.9175	4	1	7
7	R:R:Y96	7.9375	4	0	7
8	R:R:D104	8.09	6	1	9
9	R:R:F107	6.012	5	1	6
10	R:R:L111	6.62	4	1	8
11	R:R:W114	6.4975	4	0	6
12	R:R:W122	8.78714	7	2	9
13	R:R:F124	9.95	4	2	7
14	R:R:Y136	9.814	5	1	6
15	R:R:K137	6.5725	4	1	5
16	R:R:M138	5.0775	4	0	5
17	R:R:F140	10.062	5	1	7
18	R:R:M144	5.908	5	1	7
19	R:R:W145	8.73	4	0	5
20	R:R:L148	5.145	4	4	7
21	R:R:S151	6.06	4	4	9
22	R:R:Y155	4.5	5	0	8
23	R:R:I158	2.1575	4	0	8
24	R:R:W183	5.292	5	0	9
25	R:R:F220	9.366	5	5	4
26	R:R:Q227	5.12	4	0	5
27	R:R:F232	7.9025	4	1	8
28	R:R:Y243	4.9625	4	0	8
29	R:R:I262	4.02	4	0	5
30	R:R:F272	6.594	5	1	9
31	R:R:F275	5.848	5	0	7
32	R:R:Q276	8.158	5	1	8
33	R:R:Y279	7.865	6	1	6
34	R:R:N280	8.8375	4	1	8
35	R:R:T311	3.7975	4	0	6
36	R:R:Y312	7.7575	4	0	5
37	R:R:C316	5.1475	4	1	7
38	R:R:R318	8.62333	6	1	9
39	R:R:C319	6.3525	4	1	8
40	R:R:N322	6.84	4	1	9
41	R:R:Y326	6.314	5	1	9
42	R:R:K332	11.54	4	1	7
43	R:R:F333	5.234	5	1	8
44	R:R:L337	5.355	4	1	6
45	W:W:?1	10.96	11	1	0
46	I:I:?1	7.098	5	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I63	R:R:M64	13.4256	1.46	No	Yes	0	5	5
2	R:R:I63	R:R:W59	11.2188	3.52	No	No	0	5	1
3	R:R:L61	R:R:Y65	13.1832	11.72	No	Yes	0	6	7
4	R:R:M64	R:R:Y65	19.6505	4.79	Yes	Yes	0	5	7
5	R:R:L111	R:R:Y65	21.5001	11.72	Yes	Yes	0	8	7
6	R:R:Y312	R:R:Y65	16.0916	6.95	Yes	Yes	0	5	7
7	R:R:C69	R:R:L111	15.6515	4.76	No	Yes	0	6	8
8	R:R:C319	R:R:L108	11.1295	4.76	Yes	No	0	8	5
9	R:R:C319	R:R:F107	51.6934	4.19	Yes	Yes	1	8	6
10	R:R:F107	R:R:L111	33.9244	3.65	Yes	Yes	1	6	8
11	R:R:G75	R:R:P323	10.5173	4.06	No	No	0	7	9
12	R:R:C319	R:R:D104	40.5702	10.89	Yes	Yes	1	8	9
13	I:I:?1	R:R:D104	74.5775	8.05	Yes	Yes	1	0	9
14	R:R:F333	R:R:Y326	12.4243	4.13	Yes	Yes	1	8	9
15	I:I:?1	R:R:Y326	100	4.64	Yes	Yes	1	0	9
16	R:R:Y326	W:W:?1	81.7463	6.03	Yes	Yes	1	9	0
17	R:R:T95	R:R:Y83	13.7317	6.24	No	Yes	0	5	7
18	R:R:K176	R:R:T95	15.677	3	No	No	0	3	5
19	R:R:C179	R:R:K176	20.1288	6.47	No	No	0	7	3
20	R:R:C179	R:R:N99	22.3356	11.02	No	No	0	7	9
21	R:R:N99	R:R:W183	24.536	7.91	No	Yes	0	9	9
22	R:R:S142	R:R:W183	41.6289	8.65	No	Yes	0	6	9
23	R:R:G143	R:R:S142	45.7746	3.71	No	No	0	9	6
24	R:R:F272	R:R:G143	47.8283	4.52	Yes	No	0	9	9
25	R:R:F272	R:R:Q276	27.6421	4.68	Yes	Yes	1	9	8
26	R:R:Q276	R:R:Y136	48.4023	13.53	Yes	Yes	1	8	6
27	R:R:F107	R:R:Y136	25.582	11.35	Yes	Yes	1	6	6
28	R:R:F272	R:R:R318	49.4802	13.9	Yes	Yes	1	9	9
29	R:R:C319	R:R:R318	17.4565	5.57	Yes	Yes	1	8	9
30	R:R:Y136	R:R:Y279	40.7041	8.94	Yes	Yes	1	6	6
31	R:R:Y279	R:R:Y312	34.9321	12.91	Yes	Yes	0	6	5
32	R:R:T93	W:W:?1	27.6421	15.17	Yes	Yes	1	7	0
33	R:R:D153	R:R:M92	22.5652	9.7	No	Yes	0	8	6
34	R:R:D153	R:R:T93	13.955	7.23	No	Yes	0	8	7
35	R:R:D153	R:R:R154	14.1718	15.48	No	No	0	8	9
36	R:R:R154	W:W:?1	26.6535	11.81	No	Yes	0	9	0
37	R:R:I150	R:R:T93	14.3504	4.56	No	Yes	0	8	7
38	R:R:D104	R:R:L100	21.8509	4.07	Yes	No	0	9	9
39	R:R:L100	R:R:L146	20.4796	4.15	No	No	0	9	8
40	R:R:N322	R:R:R318	36.297	4.82	Yes	Yes	1	9	9
41	R:R:C316	R:R:Y312	18.9362	5.38	Yes	Yes	0	7	5
42	R:R:W114	R:R:Y312	41.208	5.79	Yes	Yes	0	6	5
43	R:R:W114	R:R:W122	28.0184	5.62	Yes	Yes	0	6	9
44	R:R:N280	R:R:Y279	19.2614	5.81	Yes	Yes	1	8	6
45	R:R:F140	R:R:N280	22.7566	12.08	Yes	Yes	1	7	8
46	R:R:F140	R:R:M144	21.3279	4.98	Yes	Yes	1	7	7
47	R:R:F140	R:R:F232	12.3924	10.72	Yes	Yes	1	7	8
48	R:R:M144	R:R:P235	39.3265	6.71	Yes	No	0	7	9
49	R:R:I182	R:R:L146	19.2997	5.71	No	No	0	6	8
50	R:R:P235	R:R:W145	37.496	16.21	No	Yes	0	9	5
51	R:R:L185	R:R:W145	51.9612	9.11	No	Yes	0	4	5
52	R:R:F272	R:R:L147	27.6867	3.65	Yes	No	0	9	8
53	R:R:L147	R:R:V269	25.9009	7.45	No	No	0	8	7
54	R:R:M239	R:R:V269	24.3702	4.56	No	No	0	7	7
55	R:R:M239	R:R:S151	19.0573	6.13	No	Yes	4	7	9
56	R:R:S151	R:R:Y243	11.5058	10.17	Yes	Yes	0	9	8
57	R:R:A157	R:R:R154	13.1641	5.53	No	No	0	8	9
58	R:R:M92	R:R:V171	11.7801	1.52	Yes	No	0	6	6
59	R:R:L189	R:R:Q227	42.0499	2.66	No	Yes	0	5	5
60	R:R:L185	R:R:L189	50.3412	2.77	No	No	0	4	5
61	R:R:I213	R:R:Y196	11.6653	4.84	No	No	0	4	4
62	R:R:Q224	R:R:Y196	13.0621	4.51	No	No	5	5	4
63	R:R:Q224	R:R:Q227	28.1204	8.96	No	Yes	0	5	5
64	R:R:F220	R:R:Q224	13.2534	15.23	Yes	No	5	4	5
65	R:R:F232	R:R:L233	15.2688	3.65	Yes	No	0	8	4
66	R:R:I158	R:R:L250	12.673	2.85	Yes	No	0	8	8
67	R:R:A157	R:R:I158	10.9892	1.62	No	Yes	0	8	8
68	R:R:I158	R:R:R258	10.2366	1.25	Yes	No	0	8	6
69	R:R:I262	R:R:R258	13.9167	1.25	Yes	No	0	5	6
70	R:R:I262	W:W:?1	26.1432	4.08	Yes	Yes	0	5	0
71	R:R:F275	R:R:R318	11.0594	8.55	Yes	Yes	0	7	9
72	R:R:Y279	R:R:Y308	16.3084	6.95	Yes	No	0	6	4
73	R:R:T311	R:R:Y279	15.1859	3.75	Yes	Yes	0	6	6
74	R:R:F140	R:R:Q276	16.2255	12.88	Yes	Yes	1	7	8
75	R:R:F272	R:R:M144	31.9982	6.22	Yes	Yes	1	9	7
76	R:R:I182	R:R:W145	19.2551	4.7	No	Yes	0	6	5
77	R:R:C316	R:R:F107	20.7858	5.59	Yes	Yes	1	7	6
78	R:R:Q276	R:R:R318	32.1513	8.18	Yes	Yes	1	8	9
79	R:R:F232	R:R:M144	11.8821	8.71	Yes	Yes	1	8	7
80	R:R:D104	R:R:R318	33.918	10.72	Yes	Yes	1	9	9
81	I:I:?1	R:R:N322	31.8643	8.15	Yes	Yes	1	0	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V79	R:R:Y326	5.05	0	No	Yes	9	9	2	1
R:R:F333	R:R:T82	7.78	1	Yes	No	8	6	1	1
R:R:L337	R:R:T82	4.42	1	Yes	No	6	6	2	1
R:R:T82	W:W:?1	4.21	1	No	Yes	6	0	1	0
R:R:F86	R:R:L89	3.65	0	No	No	5	7	2	2
R:R:D336	R:R:F86	21.5	1	No	No	5	5	1	2
R:R:K332	R:R:L89	4.23	1	Yes	No	7	7	1	2
R:R:T91	R:R:T93	4.71	1	No	Yes	7	7	1	1
R:R:D94	R:R:T91	13.01	1	No	No	8	7	1	1
R:R:T91	W:W:?1	14.33	1	No	Yes	7	0	1	0
R:R:I150	R:R:T93	4.56	0	No	Yes	8	7	2	1
R:R:D153	R:R:T93	7.23	0	No	Yes	8	7	2	1
R:R:T93	W:W:?1	15.17	1	Yes	Yes	7	0	1	0
R:R:D94	R:R:K332	8.3	1	No	Yes	8	7	1	1
R:R:D94	W:W:?1	25.61	1	No	Yes	8	0	1	0
R:R:L97	R:R:Y326	11.72	1	No	Yes	7	9	1	1
R:R:L97	W:W:?1	7.91	1	No	Yes	7	0	1	0
R:R:D153	R:R:R154	15.48	0	No	No	8	9	2	1
R:R:A157	R:R:R154	5.53	0	No	No	8	9	2	1
R:R:R154	W:W:?1	11.81	0	No	Yes	9	0	1	0
R:R:I262	R:R:V264	7.68	0	Yes	No	5	7	1	2
R:R:I262	W:W:?1	4.08	0	Yes	Yes	5	0	1	0
R:R:F333	R:R:Y326	4.13	1	Yes	Yes	8	9	1	1
R:R:Y326	W:W:?1	6.03	1	Yes	Yes	9	0	1	0
I:I:?1	R:R:Y326	4.64	1	Yes	Yes	0	9	2	1
R:R:D336	R:R:K332	11.06	1	No	Yes	5	7	1	1
R:R:K332	W:W:?1	22.57	1	Yes	Yes	7	0	1	0
R:R:F333	R:R:L337	7.31	1	Yes	Yes	8	6	1	2
R:R:F333	W:W:?1	4.18	1	Yes	Yes	8	0	1	0
R:R:D336	W:W:?1	4.66	1	No	Yes	5	0	1	0
R:R:I262	R:R:V331	3.07	0	Yes	No	5	5	1	2
R:R:A327	R:R:F333	2.77	0	No	Yes	7	8	2	1
R:R:I262	R:R:R258	1.25	0	Yes	No	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Consensus	ccr7_off_allo	Other Ligand	6QZH-CCR7-HY-133073; Na
53.33	Single	6LFL	PubChem 153466996	6LFL-CXCR2-PubChem 153466996
47.06	Single	5LWE	Vercirnon	5LWE-CCR9-Vercirnon
47.06	Consensus	ccr9_off_allo	Other Ligand	5LWE-CCR9-Vercirnon
35.71	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
33.33	Consensus	ccr2_off_allo	Other Ligand	5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
23.53	Single	5X7D	PubChem 129318963	5X7D-β₂-(S)-Carazolol-PubChem 129318963
22.22	Single	3VG9	Antibody	3VG9-A_2A-ZM241385-Antibody
21.05	Single	8FN0	PubChem 118610427	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
21.05	Single	8JPC	PubChem 118610427; GDP; Mg	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
20.69	Single	3VGA	Antibody	3VGA-A_2A-ZM241385-Antibody
20.00	Single	8JPB	PubChem 118610427; GDP; Mg	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
17.65	Consensus	nts1_on_allo	Other Ligand	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
15.79	Single	8JPF	PubChem 118610427	8JPF-NTS₁-Neurotensin-PubChem 118610427
15.79	Single	8JR9	PCO371	8JR9-PTH1-PCO371-chim(NtGi1-Gs)/&β;1/&γ;2
15.00	Single	8GW8	KHF	8GW8-PTH1-KHF-Gs/&β;1/&γ;2
9.52	Consensus	ffa3_on_allo	Other Ligand	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
9.09	Single	8J20	AR420626	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
8.70	Single	8TB7	PubChem 168510218	8TB7-GPR61-PubChem 168510218
8.33	Single	7EVM	PubChem 156022738	7EVM-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
7.14	Single	4PXF	Octyl Beta-D-Glucopyranoside	4PXF-Rhodopsin-Octyl Beta-D-Glucopyranoside-Arrestin1_Finger_loop
7.14	Single	7DUQ	PubChem 156022738	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
5.00	Single	7EJX	(1R;2R)-2-PCCA	7EJX-GPR88-(1R;2R)-2-PCCA-Gi1/&β;1/&γ;2
4.55	Single	5XF1	NNC0640	5XF1-Glucagon-NNC0640
4.17	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.00	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
3.85	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
3.57	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2

PDB Summary
PDB	6QZH
Class	A
SubFamily	Protein
Type	Chemokine
SubType	CCR7
Species	Homo sapiens
Ligand	-
Other Ligand(s)	HY-133073; Na
Protein Partners	-
PDB Resolution	2.1
Date	2019-09-04
D.O.I.	10.1016/j.cell.2019.07.028

Net Summary
I_min	3.65
Number of Linked Nodes	252
Number of Links	281
Number of Hubs	46
Number of Links mediated by Hubs	165
Number of Communities	5
Number of Nodes involved in Communities	45
Number of Links involved in Communities	66

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	42650
Length Of Smallest Path	3
Average Path Length	11.3542
Length of Longest Path	24
Minimum Path Strength	1.365
Average Path Strength	6.80225
Maximum Path Strength	18.87
Minimum Path Correlation	0.7
Average Path Correlation	0.925054
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	58.7443
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	57.862
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	JLW
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	JLW
Name	3-[[4-[[(1~{R})-2,2-dimethyl-1-(5-methylfuran-2-yl)propyl]amino]-1,1-bis(oxidanylidene)-1,2,5-thiadiazol-3-yl]amino]-~{N},~{N},6-trimethyl-2-oxidanyl-benzamide
Synonyms
Identifier	3-[[4-[[(1~{R})-2,2-dimethyl-1-(5-methylfuran-2-yl)propyl]amino]-1,1-bis(oxidanylidene)-1,2,5-thiadiazol-3-yl]amino]-~{N},~{N},6-trimethyl-2-oxidanyl-benzamide
Formula	C22 H29 N5 O5 S
Molecular Weight	475.561
SMILES	Cc1ccc(c(c1C(=O)N(C)C)O)NC2=NS(=O)(=O)N=C2N[C@@H](c3ccc(o3)C)C(C)(C)C
PubChem	136165388
Formal Charge	0
Total Atoms	62
Total Chiral Atoms	1
Total Bonds	64
Total Aromatic Bonds	11


Code	NA
PDB Residues	I:I:?1
Environment Details	Open EMBL-EBI Page
Code	NA
Name	SODIUM ION
Synonyms
Identifier	sodium(+1) cation
Formula	Na
Molecular Weight	22.99
SMILES	[Na+]
PubChem
Formal Charge	1
Total Atoms	1
Total Chiral Atoms	0
Total Bonds	0
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32248
Sequence	>6QZH_Chain_R D V R N F K A W F L P I M Y S I I C F V G L L G N G L V V L T Y I Y F K R L K T M T D T Y L L N L A V A D I L F L L T L P F W A Y S A A K S W V F G V H F C K L I F A I Y K M S F F S G M W L L L C I S I D R Y V A I V H R H R A R V L L I S K L S C V G I W I L A T V L S I P E L L Y S D L Q R S S S E Q A M R C S L I T E H V E A F I T I Q V A Q M V I G F L V P L L A M S F C Y L V I I S K L H G H E R N I K V I I A V V V V F I V F Q L P Y N G V V L A Q T V T C E L S K Q L N I A Y D V T Y S L A C V R C C V N P F L Y A F I G V K F R N D L F K L F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This network is also present in following consensuses:
	Id	Components
	ccr7_off_allo	6QZH-CCR7-HY-133073; Na

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6QZH	A	Protein	Chemokine	CCR7	Homo sapiens	-	HY-133073; Na	-	2.1	2019-09-04	10.1016/j.cell.2019.07.028

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