psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D35	R:R:N32	9.42	No	No	0	7	7
2	R:R:D35	R:R:N41	4.04	No	No	0	7	3
3	R:R:C289	R:R:C38	7.28	No	No	0	6	7
4	R:R:D296	R:R:R44	3.57	No	No	0	4	4
5	R:R:Q300	R:R:R44	3.5	No	No	0	4	4
6	R:R:A47	R:R:Q300	4.55	No	No	0	5	4
7	R:R:F50	R:R:L54	7.31	No	No	0	6	5
8	R:R:L51	R:R:Y55	9.38	No	Yes	0	5	8
9	R:R:P52	R:R:P53	5.84	Yes	No	0	5	5
10	R:R:A108	R:R:P52	3.74	No	Yes	0	5	5
11	R:R:W104	R:R:Y55	5.79	Yes	Yes	1	6	8
12	R:R:Q303	R:R:Y55	5.64	Yes	Yes	1	6	8
13	R:R:F307	R:R:Y55	14.44	Yes	Yes	1	7	8
14	R:R:P102	R:R:W56	5.4	No	No	0	8	4
15	R:R:A105	R:R:W56	7.78	No	No	0	6	4
16	R:R:F308	R:R:V58	5.24	Yes	No	3	6	7
17	R:R:C311	R:R:V58	3.42	No	No	3	8	7
18	R:R:F59	R:R:I60	3.77	No	No	0	7	6
19	R:R:F59	R:R:P102	14.45	No	No	0	7	8
20	R:R:C311	R:R:V61	5.12	No	No	0	8	6
21	R:R:G62	R:R:L98	3.42	No	No	0	8	6
22	R:R:G65	R:R:P314	4.06	No	No	0	8	9
23	R:R:A91	R:R:N66	4.69	No	Yes	0	9	9
24	R:R:D94	R:R:N66	10.77	No	Yes	0	9	9
25	R:R:L95	R:R:N66	5.49	No	Yes	0	7	9
26	R:R:N66	R:R:P314	6.52	Yes	No	0	9	9
27	R:R:L328	R:R:L68	4.15	No	No	2	6	6
28	R:R:A91	R:R:V69	3.39	No	No	0	9	8
29	R:R:P314	R:R:V69	3.53	No	No	0	9	8
30	R:R:I70	R:R:L88	4.28	No	No	0	7	5
31	R:R:L71	R:R:Y75	3.52	No	Yes	4	4	5
32	R:R:L335	R:R:L71	4.15	No	No	4	2	4
33	R:R:F324	R:R:V72	5.24	Yes	Yes	2	8	7
34	R:R:T331	R:R:V72	7.93	No	Yes	0	4	7
35	R:R:W74	R:R:Y73	13.5	No	Yes	0	4	7
36	R:R:K80	R:R:Y73	23.89	No	Yes	0	7	7
37	R:R:L88	R:R:Y73	17.58	No	Yes	0	5	7
38	R:R:Y73	W:W:?1	4.48	Yes	Yes	0	7	0
39	R:R:T331	R:R:Y75	3.75	No	Yes	0	4	5
40	R:R:L335	R:R:Y75	10.55	No	Yes	4	2	5
41	R:R:C76	R:R:R78	4.18	No	Yes	2	6	6
42	R:R:C76	R:R:K80	4.85	No	No	0	6	7
43	R:R:C76	R:R:D327	6.22	No	No	2	6	4
44	R:R:D84	R:R:R78	10.72	No	Yes	2	8	6
45	R:R:R323	R:R:R78	14.93	No	Yes	2	6	6
46	R:R:D327	R:R:R78	15.48	No	Yes	2	4	6
47	R:R:R78	W:W:?1	3.32	Yes	Yes	2	6	0
48	R:R:D84	R:R:T81	10.12	No	No	2	8	7
49	R:R:T81	W:W:?1	4.83	No	Yes	2	7	0
50	R:R:A82	R:R:D143	6.18	No	Yes	0	6	8
51	R:R:A82	R:R:S165	3.42	No	Yes	0	6	7
52	R:R:D143	R:R:T83	7.23	Yes	No	2	8	8
53	R:R:R144	R:R:T83	11.64	Yes	No	2	9	8
54	R:R:T83	W:W:?1	7.25	No	Yes	2	8	0
55	R:R:D84	W:W:?1	14.09	No	Yes	2	8	0
56	R:R:M85	R:R:N89	5.61	Yes	No	5	7	9
57	R:R:M85	R:R:S165	6.13	Yes	Yes	0	7	7
58	R:R:K166	R:R:M85	5.76	No	Yes	0	3	7
59	R:R:C169	R:R:M85	4.86	No	Yes	5	7	7
60	R:R:C139	R:R:F86	11.17	No	Yes	0	7	7
61	R:R:F86	R:R:I140	5.02	Yes	No	0	7	8
62	R:R:F86	R:R:S165	5.28	Yes	Yes	0	7	7
63	R:R:F86	R:R:V168	3.93	Yes	No	0	7	6
64	R:R:L87	R:R:Y317	5.86	No	Yes	2	8	9
65	R:R:L87	W:W:?1	15.13	No	Yes	2	8	0
66	R:R:I92	R:R:L88	4.28	No	No	0	6	5
67	R:R:C169	R:R:N89	11.02	No	No	5	7	9
68	R:R:N89	R:R:W173	7.91	No	No	0	9	9
69	R:R:L136	R:R:L90	4.15	No	No	0	8	9
70	R:R:I92	R:R:W173	3.52	No	No	0	6	9
71	R:R:D94	R:R:N129	5.39	No	Yes	1	9	8
72	R:R:D94	R:R:S310	5.89	No	Yes	1	9	9
73	R:R:F97	R:R:L101	4.87	Yes	No	0	7	8
74	R:R:F97	R:R:Y126	4.13	Yes	Yes	1	7	7
75	R:R:F97	R:R:N129	4.83	Yes	Yes	1	7	8
76	R:R:F307	R:R:F97	13.93	Yes	Yes	1	7	7
77	R:R:F97	R:R:S310	7.93	Yes	Yes	1	7	9
78	R:R:L98	R:R:S310	6.01	No	Yes	0	6	9
79	R:R:T100	R:R:V122	4.76	No	No	0	7	5
80	R:R:F103	R:R:M118	7.46	No	Yes	0	7	6
81	R:R:M118	R:R:W104	3.49	Yes	Yes	0	6	6
82	R:R:V122	R:R:W104	11.03	No	Yes	0	5	6
83	R:R:Q303	R:R:W104	8.76	Yes	Yes	1	6	6
84	R:R:M118	R:R:V121	4.56	Yes	No	0	6	5
85	R:R:I184	R:R:S124	4.64	No	No	0	5	5
86	R:R:K127	R:R:Y126	3.58	No	Yes	0	5	7
87	R:R:F130	R:R:Y126	6.19	Yes	Yes	1	8	7
88	R:R:Q267	R:R:Y126	9.02	Yes	Yes	1	9	7
89	R:R:Y126	R:R:Y270	12.91	Yes	Yes	1	7	7
90	R:R:N271	R:R:Y126	5.81	No	Yes	1	8	7
91	R:R:A306	R:R:Y126	4	No	Yes	1	8	7
92	R:R:F307	R:R:Y126	6.19	Yes	Yes	1	7	7
93	R:R:K127	R:R:Y131	10.75	No	No	0	5	7
94	R:R:E183	R:R:K127	12.15	No	No	0	4	5
95	R:R:C180	R:R:M128	3.24	No	No	0	6	5
96	R:R:C133	R:R:N129	4.72	No	Yes	0	9	8
97	R:R:N129	R:R:S310	4.47	Yes	Yes	1	8	9
98	R:R:F130	R:R:Y131	4.13	Yes	No	0	8	7
99	R:R:F130	R:R:V134	5.24	Yes	No	0	8	8
100	R:R:F130	R:R:P226	5.78	Yes	No	0	8	9
101	R:R:F130	R:R:F263	3.22	Yes	Yes	1	8	9
102	R:R:F130	R:R:Q267	8.2	Yes	Yes	1	8	9
103	R:R:F130	R:R:N271	14.5	Yes	No	1	8	8
104	R:R:L179	R:R:Y131	11.72	No	No	0	6	7
105	R:R:A176	R:R:S132	3.42	No	No	0	8	7
106	R:R:C133	R:R:F263	5.59	No	Yes	0	9	9
107	R:R:V134	R:R:V229	3.21	No	No	0	8	7
108	R:R:I172	R:R:L135	9.99	No	No	0	7	6
109	R:R:I172	R:R:L136	4.28	No	No	0	7	8
110	R:R:F263	R:R:I137	5.02	Yes	No	0	9	8
111	R:R:M138	R:R:V229	4.56	No	No	0	7	7
112	R:R:C233	R:R:M138	3.24	No	No	0	7	7
113	R:R:C141	R:R:C233	3.64	No	No	0	9	7
114	R:R:C141	R:R:I236	3.27	No	No	0	9	3
115	R:R:C141	R:R:I237	3.27	No	No	0	9	8
116	R:R:D143	R:R:R144	5.96	Yes	Yes	2	8	9
117	R:R:D143	R:R:R161	11.91	Yes	No	0	8	7
118	R:R:A147	R:R:R144	5.53	No	Yes	0	8	9
119	R:R:R144	R:R:T256	6.47	Yes	No	2	9	7
120	R:R:R144	W:W:?1	11.95	Yes	Yes	2	9	0
121	R:R:A149	R:R:Y145	4	No	Yes	0	7	8
122	R:R:Q150	R:R:Y145	4.51	No	Yes	0	7	8
123	R:R:T240	R:R:Y145	9.99	No	Yes	0	5	8
124	R:R:Q243	R:R:Y145	10.15	No	Yes	0	4	8
125	R:R:I146	R:R:R153	3.76	No	No	0	5	5
126	R:R:A252	R:R:I148	3.25	No	No	0	8	8
127	R:R:I148	R:R:L253	4.28	No	No	0	8	6
128	R:R:Q150	R:R:R153	3.5	No	No	0	7	5
129	R:R:R153	R:R:W157	14.99	No	No	0	5	4
130	R:R:A154	R:R:R161	5.53	No	No	0	5	7
131	R:R:H155	R:R:R158	15.8	No	No	0	5	4
132	R:R:T156	R:R:W157	12.13	No	No	0	5	4
133	R:R:K160	R:R:W157	6.96	No	No	0	6	4
134	R:R:E159	R:R:K160	13.5	No	No	0	3	6
135	R:R:F170	R:R:V174	5.24	No	No	0	4	4
136	R:R:L179	R:R:L221	4.15	No	No	0	6	5
137	R:R:I181	R:R:P182	5.08	No	No	0	4	7
138	R:R:K218	R:R:V214	6.07	No	No	0	5	5
139	R:R:L215	R:R:Y282	12.89	No	Yes	0	5	1
140	R:R:K218	R:R:Y282	3.58	No	Yes	0	5	1
141	R:R:F223	R:R:L275	12.18	Yes	No	0	8	6
142	R:R:F223	R:R:T278	3.89	Yes	No	0	8	5
143	R:R:F224	R:R:V228	7.87	No	No	0	5	3
144	R:R:M230	R:R:V264	6.09	No	No	0	8	5
145	R:R:C233	R:R:L260	6.35	No	No	0	7	8
146	R:R:L260	R:R:Y234	15.24	No	No	0	8	8
147	R:R:T261	R:R:Y234	6.24	No	No	0	5	8
148	R:R:V264	R:R:Y234	3.79	No	No	0	5	8
149	R:R:I237	R:R:I257	4.42	No	No	0	8	5
150	R:R:A244	R:R:K249	4.82	No	No	0	6	7
151	R:R:K246	R:R:S248	4.59	No	No	0	4	4
152	R:R:H250	R:R:K249	9.17	No	No	0	6	7
153	R:R:E322	R:R:K251	6.75	No	No	0	4	7
154	R:R:L253	R:R:T256	4.42	No	No	0	6	7
155	R:R:K254	R:R:V320	6.07	No	No	0	5	7
156	R:R:A255	W:W:?1	8.61	No	Yes	0	8	0
157	R:R:T256	W:W:?1	7.25	No	Yes	2	7	0
158	R:R:T258	R:R:V320	9.52	No	No	0	6	7
159	R:R:N313	R:R:V259	5.91	No	No	0	9	8
160	R:R:V259	W:W:?1	4.07	No	Yes	0	8	0
161	R:R:H309	R:R:V262	5.54	Yes	No	0	9	7
162	R:R:L316	R:R:V262	5.96	No	No	0	8	7
163	R:R:F263	R:R:Q267	7.03	Yes	Yes	1	9	9
164	R:R:F263	R:R:H309	9.05	Yes	Yes	1	9	9
165	R:R:Q267	R:R:S266	7.22	Yes	No	1	9	9
166	R:R:H309	R:R:S266	11.16	Yes	No	1	9	9
167	R:R:A306	R:R:Q267	4.55	No	Yes	1	8	9
168	R:R:H309	R:R:Q267	3.71	Yes	Yes	1	9	9
169	R:R:F268	R:R:P269	4.33	No	No	0	6	9
170	R:R:C272	R:R:F268	8.38	No	No	0	7	6
171	R:R:P269	R:R:T302	3.5	No	No	0	9	6
172	R:R:L274	R:R:Y270	16.41	No	Yes	0	6	7
173	R:R:F299	R:R:Y270	6.19	Yes	Yes	1	4	7
174	R:R:T302	R:R:Y270	6.24	No	Yes	0	6	7
175	R:R:Q303	R:R:Y270	16.91	Yes	Yes	1	6	7
176	R:R:A306	R:R:Y270	4	No	Yes	1	8	7
177	R:R:C298	R:R:I273	3.27	No	No	0	5	5
178	R:R:I273	R:R:T302	4.56	No	No	0	5	6
179	R:R:I279	R:R:L275	4.28	No	No	0	4	6
180	R:R:F299	R:R:Q277	12.88	Yes	No	0	4	4
181	R:R:F285	R:R:I279	3.77	Yes	No	0	1	4
182	R:R:D280	R:R:F285	15.52	No	Yes	6	2	1
183	R:R:D280	R:R:I286	13.99	No	Yes	6	2	2
184	R:R:F285	R:R:I286	5.02	Yes	Yes	6	1	2
185	R:R:I286	R:R:V291	4.61	Yes	No	0	2	1
186	R:R:N288	R:R:V291	5.91	No	No	0	3	1
187	R:R:F299	R:R:Q300	3.51	Yes	No	0	4	4
188	R:R:F299	R:R:Q303	5.86	Yes	Yes	1	4	6
189	R:R:F307	R:R:Q303	14.05	Yes	Yes	1	7	6
190	R:R:C311	R:R:F308	4.19	No	Yes	3	8	6
191	R:R:F308	R:R:L312	7.31	Yes	No	0	6	7
192	R:R:H309	R:R:N313	5.1	Yes	No	0	9	9
193	R:R:N313	R:R:Y317	10.47	No	Yes	0	9	9
194	R:R:F324	R:R:Y317	5.16	Yes	Yes	2	8	9
195	R:R:Y317	W:W:?1	10.89	Yes	Yes	2	9	0
196	R:R:G321	W:W:?1	3.74	No	Yes	0	8	0
197	R:R:D327	R:R:R323	5.96	No	No	2	4	6
198	R:R:R323	W:W:?1	14.6	No	Yes	2	6	0
199	R:R:F324	W:W:?1	11.31	Yes	Yes	2	8	0
200	R:R:K333	R:R:V329	4.55	No	No	0	5	5
201	R:R:C133	R:R:L90	3.17	No	No	0	9	9
202	R:R:F33	R:R:Y37	3.09	No	No	0	4	2
203	R:R:F36	R:R:Y37	3.09	No	No	0	3	2
204	R:R:I297	R:R:V43	3.07	No	No	0	1	3
205	R:R:I148	R:R:T240	3.04	No	No	0	8	5
206	R:R:A252	R:R:E322	3.02	No	No	0	8	4
207	R:R:M125	R:R:T100	3.01	No	No	0	5	7
208	R:R:F223	R:R:G222	3.01	Yes	No	0	8	6
209	R:R:L95	R:R:S67	3	No	No	0	7	4
210	R:R:L162	R:R:S165	3	No	Yes	0	3	7
211	R:R:L57	R:R:V61	2.98	No	No	0	4	6
212	R:R:L101	R:R:V58	2.98	No	No	0	8	7
213	R:R:L68	R:R:V72	2.98	No	Yes	2	6	7
214	R:R:L328	R:R:V72	2.98	No	Yes	2	6	7
215	R:R:L215	R:R:V219	2.98	No	No	0	5	6
216	R:R:N288	R:R:S287	2.98	No	No	0	3	1
217	R:R:L316	R:R:T258	2.95	No	No	0	8	6
218	R:R:L265	R:R:T261	2.95	No	No	0	5	5
219	R:R:I238	R:R:I242	2.94	No	No	0	5	4
220	R:R:M125	R:R:M128	2.89	No	No	0	5	5
221	R:R:L96	R:R:M125	2.83	No	No	0	7	5
222	R:R:I338	R:R:N334	2.83	No	No	0	3	4
223	R:R:K249	R:R:L241	2.82	No	No	0	7	8
224	R:R:L135	R:R:L175	2.77	No	No	0	6	4
225	R:R:L241	R:R:L253	2.77	No	No	0	8	6
226	R:R:H239	R:R:T235	2.74	No	No	0	3	4
227	R:R:I295	R:R:Q277	2.74	No	No	0	4	4
228	R:R:A281	R:R:Y282	2.67	No	Yes	0	3	1
229	R:R:F319	R:R:V315	2.62	No	No	0	6	6
230	R:R:F324	R:R:V318	2.62	Yes	No	0	8	7
231	R:R:A93	R:R:W173	2.59	No	No	0	8	9
232	R:R:F308	R:R:L54	2.44	Yes	No	0	6	5
233	R:R:F223	R:R:L274	2.44	Yes	No	0	8	6
234	R:R:I338	R:R:Y75	2.42	No	Yes	0	3	5
235	R:R:K211	R:R:Y282	2.39	No	Yes	0	3	1
236	R:R:A109	R:R:P52	1.87	No	Yes	0	4	5
237	R:R:G336	R:R:S339	1.86	No	No	0	4	5
238	R:R:A109	R:R:S48	1.71	No	No	0	4	6
239	R:R:G65	R:R:L64	1.71	No	No	0	8	5
240	R:R:A93	R:R:S132	1.71	No	No	0	8	7
241	R:R:C232	R:R:V228	1.71	No	No	0	5	3
242	R:R:C289	R:R:T293	1.69	No	No	0	6	2
243	R:R:A290	R:R:T293	1.68	No	No	0	1	2
244	R:R:L51	R:R:P52	1.64	No	Yes	0	5	5
245	R:R:L101	R:R:P102	1.64	No	No	0	8	8
246	R:R:L225	R:R:P226	1.64	No	No	0	6	9
247	R:R:A283	R:R:I279	1.62	No	No	0	3	4
248	R:R:A177	R:R:M128	1.61	No	No	0	3	5
249	R:R:T100	R:R:V99	1.59	No	No	0	7	5
250	R:R:A304	R:R:L54	1.58	No	No	0	5	5
251	R:R:A63	R:R:L95	1.58	No	No	0	6	7
252	R:R:C119	R:R:N123	1.57	No	No	0	9	5
253	R:R:A77	R:R:N334	1.56	No	No	0	6	4
254	R:R:I305	R:R:S266	1.55	No	No	0	8	9
255	R:R:I286	R:R:S292	1.55	Yes	No	0	2	3
256	R:R:I146	R:R:V142	1.54	No	No	0	5	6
257	R:R:I236	R:R:V142	1.54	No	No	0	3	6
258	R:R:I297	R:R:V301	1.54	No	No	0	1	5
259	R:R:I305	R:R:V301	1.54	No	No	0	8	5
260	R:R:M152	R:R:T156	1.51	No	No	0	6	5
261	R:R:K209	R:R:T208	1.5	No	No	0	1	1
262	R:R:L210	R:R:V214	1.49	No	No	0	3	5
263	R:R:L275	R:R:V219	1.49	No	No	0	6	6
264	R:R:I181	R:R:I184	1.47	No	No	0	4	5
265	R:R:L163	R:R:M167	1.41	No	No	0	4	2
266	R:R:N41	R:R:Q45	1.32	No	No	0	3	2
267	R:R:C119	R:R:W104	1.31	No	Yes	0	9	6
268	R:R:E183	R:R:N123	1.31	No	No	0	4	5
269	R:R:F227	R:R:V228	1.31	No	No	0	7	3
270	R:R:F285	R:R:V276	1.31	Yes	No	0	1	5
271	R:R:F319	R:R:V318	1.31	No	No	0	6	7
272	R:R:F319	R:R:V320	1.31	No	No	0	6	7
273	R:R:D35	R:R:E34	1.3	No	No	0	7	6
274	R:R:F224	R:R:I220	1.26	No	No	0	5	5
275	R:R:F117	R:R:M118	1.24	No	Yes	0	3	6
276	R:R:H239	R:R:Q243	1.24	No	No	0	3	4
277	R:R:M167	R:R:Y164	1.2	No	No	0	2	3
278	R:R:I106	R:R:W56	1.17	No	No	0	4	4
279	R:R:R158	R:R:R161	1.07	No	No	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P52	3.2725	4	0	5
2	R:R:Y55	8.8125	4	1	8
3	R:R:N66	6.8675	4	0	9
4	R:R:V72	4.7825	4	2	7
5	R:R:Y73	14.8625	4	0	7
6	R:R:Y75	5.06	4	4	5
7	R:R:R78	9.726	5	2	6
8	R:R:M85	5.59	4	5	7
9	R:R:F86	6.35	4	0	7
10	R:R:F97	7.138	5	1	7
11	R:R:W104	6.076	5	1	6
12	R:R:M118	4.1875	4	0	6
13	R:R:Y126	6.47875	8	1	7
14	R:R:N129	4.8525	4	1	8
15	R:R:F130	6.75143	7	1	8
16	R:R:D143	7.82	4	2	8
17	R:R:R144	8.31	5	2	9
18	R:R:Y145	7.1625	4	0	8
19	R:R:S165	4.4575	4	0	7
20	R:R:F223	5.38	4	0	8
21	R:R:F263	5.982	5	1	9
22	R:R:Q267	6.62167	6	1	9
23	R:R:Y270	10.4433	6	1	7
24	R:R:Y282	5.3825	4	0	1
25	R:R:F285	6.405	4	6	1
26	R:R:I286	6.2925	4	6	2
27	R:R:F299	7.11	4	1	4
28	R:R:Q303	10.244	5	1	6
29	R:R:F307	12.1525	4	1	7
30	R:R:F308	4.795	4	3	6
31	R:R:H309	6.912	5	1	9
32	R:R:S310	6.075	4	1	9
33	R:R:Y317	8.095	4	2	9
34	R:R:F324	6.0825	4	2	8
35	W:W:?1	8.68	14	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Y126	R:R:Y270	35.3365	12.91	Yes	Yes	1	7	7
2	R:R:F97	R:R:Y126	18.8565	4.13	Yes	Yes	1	7	7
3	R:R:F97	R:R:L101	14.0457	4.87	Yes	No	0	7	8
4	R:R:F307	R:R:Q303	11.4327	14.05	Yes	Yes	1	7	6
5	R:R:Q303	R:R:W104	25.6651	8.76	Yes	Yes	1	6	6
6	R:R:D94	R:R:N129	10.3785	5.39	No	Yes	1	9	8
7	R:R:D94	R:R:N66	13.2466	10.77	No	Yes	0	9	9
8	R:R:Q267	R:R:Y126	54.5846	9.02	Yes	Yes	1	9	7
9	R:R:H309	R:R:Q267	83.0599	3.71	Yes	Yes	1	9	9
10	R:R:H309	R:R:N313	100	5.1	Yes	No	0	9	9
11	R:R:N313	R:R:Y317	54.6609	10.47	No	Yes	0	9	9
12	R:R:A306	R:R:Y270	24.8186	4	No	Yes	1	8	7
13	R:R:A306	R:R:Q267	25.2208	4.55	No	Yes	1	8	9
14	R:R:N313	R:R:V259	45.1577	5.91	No	No	0	9	8
15	R:R:V259	W:W:?1	44.7503	4.07	No	Yes	0	8	0
16	R:R:Y73	W:W:?1	17.1293	4.48	Yes	Yes	0	7	0
17	R:R:L88	R:R:Y73	12.918	17.58	No	Yes	0	5	7
18	R:R:Y317	W:W:?1	44.7266	10.89	Yes	Yes	2	9	0
19	R:R:A82	R:R:D143	28.1467	6.18	No	Yes	0	6	8
20	R:R:D143	R:R:T83	20.3654	7.23	Yes	No	2	8	8
21	R:R:T83	W:W:?1	21.6719	7.25	No	Yes	2	8	0
22	R:R:D143	R:R:R144	21.6193	5.96	Yes	Yes	2	8	9
23	R:R:R144	W:W:?1	22.9784	11.95	Yes	Yes	2	9	0
24	R:R:A82	R:R:S165	25.3707	3.42	No	Yes	0	6	7
25	R:R:I92	R:R:L88	10.0683	4.28	No	No	0	6	5
26	R:R:F86	R:R:S165	11.3644	5.28	Yes	Yes	0	7	7
27	R:R:F130	R:R:Y126	11.622	6.19	Yes	Yes	1	8	7
28	R:R:F130	R:R:F263	10.765	3.22	Yes	Yes	1	8	9
29	R:R:C133	R:R:F263	13.3833	5.59	No	Yes	0	9	9
30	R:R:V122	R:R:W104	20.6283	11.03	No	Yes	0	5	6
31	R:R:T100	R:R:V122	18.0678	4.76	No	No	0	7	5
32	R:R:M118	R:R:W104	10.3549	3.49	Yes	Yes	0	6	6
33	R:R:M125	R:R:T100	12.9311	3.01	No	No	0	5	7
34	R:R:F130	R:R:V134	20.3523	5.24	Yes	No	0	8	8
35	R:R:V134	R:R:V229	19.1299	3.21	No	No	0	8	7
36	R:R:M138	R:R:V229	17.9154	4.56	No	No	0	7	7
37	R:R:C233	R:R:M138	16.7482	3.24	No	No	0	7	7
38	R:R:D143	R:R:R161	11.3959	11.91	Yes	No	0	8	7
39	R:R:T256	W:W:?1	22.5789	7.25	No	Yes	2	7	0
40	R:R:T240	R:R:Y145	10.234	9.99	No	Yes	0	5	8
41	R:R:I148	R:R:T240	11.4905	3.04	No	No	0	8	5
42	R:R:I148	R:R:L253	16.5142	4.28	No	No	0	8	6
43	R:R:L253	R:R:T256	22.7445	4.42	No	No	0	6	7
44	R:R:L274	R:R:Y270	30.1656	16.41	No	Yes	0	6	7
45	R:R:F223	R:R:L274	28.9012	2.44	Yes	No	0	8	6
46	R:R:F223	R:R:L275	25.0868	12.18	Yes	No	0	8	6
47	R:R:L275	R:R:V219	10.7781	1.49	No	No	0	6	6
48	R:R:I279	R:R:L275	13.4437	4.28	No	No	0	4	6
49	R:R:F285	R:R:I279	10.7781	3.77	Yes	No	0	1	4
50	R:R:F307	R:R:Y55	14.6477	14.44	Yes	Yes	1	7	8
51	R:R:W104	R:R:Y55	10.0289	5.79	Yes	Yes	1	6	8
52	R:R:F307	R:R:Y126	20.9989	6.19	Yes	Yes	1	7	7
53	R:R:Q303	R:R:Y270	17.3817	16.91	Yes	Yes	1	6	7
54	R:R:F263	R:R:H309	18.5147	9.05	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F324	R:R:V72	5.24	2	Yes	Yes	8	7	1	2
R:R:W74	R:R:Y73	13.5	0	No	Yes	4	7	2	1
R:R:K80	R:R:Y73	23.89	0	No	Yes	7	7	2	1
R:R:L88	R:R:Y73	17.58	0	No	Yes	5	7	2	1
R:R:Y73	W:W:?1	4.48	0	Yes	Yes	7	0	1	0
R:R:C76	R:R:R78	4.18	2	No	Yes	6	6	2	1
R:R:C76	R:R:K80	4.85	2	No	No	6	7	2	2
R:R:C76	R:R:D327	6.22	2	No	No	6	4	2	2
R:R:D84	R:R:R78	10.72	2	No	Yes	8	6	1	1
R:R:R323	R:R:R78	14.93	2	No	Yes	6	6	1	1
R:R:D327	R:R:R78	15.48	2	No	Yes	4	6	2	1
R:R:R78	W:W:?1	3.32	2	Yes	Yes	6	0	1	0
R:R:D84	R:R:T81	10.12	2	No	No	8	7	1	1
R:R:T81	W:W:?1	4.83	2	No	Yes	7	0	1	0
R:R:D143	R:R:T83	7.23	2	Yes	No	8	8	2	1
R:R:R144	R:R:T83	11.64	2	Yes	No	9	8	1	1
R:R:T83	W:W:?1	7.25	2	No	Yes	8	0	1	0
R:R:D84	W:W:?1	14.09	2	No	Yes	8	0	1	0
R:R:L87	R:R:Y317	5.86	2	No	Yes	8	9	1	1
R:R:L87	W:W:?1	15.13	2	No	Yes	8	0	1	0
R:R:D143	R:R:R144	5.96	2	Yes	Yes	8	9	2	1
R:R:A147	R:R:R144	5.53	0	No	Yes	8	9	2	1
R:R:R144	R:R:T256	6.47	2	Yes	No	9	7	1	1
R:R:R144	W:W:?1	11.95	2	Yes	Yes	9	0	1	0
R:R:L253	R:R:T256	4.42	0	No	No	6	7	2	1
R:R:A255	W:W:?1	8.61	0	No	Yes	8	0	1	0
R:R:T256	W:W:?1	7.25	2	No	Yes	7	0	1	0
R:R:N313	R:R:V259	5.91	0	No	No	9	8	2	1
R:R:V259	W:W:?1	4.07	0	No	Yes	8	0	1	0
R:R:N313	R:R:Y317	10.47	0	No	Yes	9	9	2	1
R:R:F324	R:R:Y317	5.16	2	Yes	Yes	8	9	1	1
R:R:Y317	W:W:?1	10.89	2	Yes	Yes	9	0	1	0
R:R:G321	W:W:?1	3.74	0	No	Yes	8	0	1	0
R:R:D327	R:R:R323	5.96	2	No	No	4	6	2	1
R:R:R323	W:W:?1	14.6	2	No	Yes	6	0	1	0
R:R:F324	W:W:?1	11.31	2	Yes	Yes	8	0	1	0
R:R:F324	R:R:V318	2.62	2	Yes	No	8	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
73.33	Single	6LFL	PubChem 153466996	6LFL-CXCR2-PubChem 153466996
57.14	Single	5T1A	PubChem 12093170	5T1A-CCR2-BMS-681-PubChem 12093170
47.06	Single	6QZH	PubChem 136165388; Na	6QZH-CCR7-PubChem 136165388; Na
42.11	Single	9PEE	PF-07054894; OXM2	9PEE-CCR6-PF-07054894; OXM2
41.18	Single	5X7D	PubChem 129318963	5X7D-β₂-Carazolol-PubChem 129318963
38.89	Single	8JPF	SBI-553	8JPF-NTS₁-Neurotensin-(8-13)-SBI-553
34.78	Single	8FN0	SBI-553	8FN0-NTS₁-Neurotensin-(8-13)-SBI-553-chim(NtGi1-Go)/β1/γ2
34.78	Single	8ZYT	SBI-553	8ZYT-NTS₁-Neurotensin-(8-13)-SBI-553-Arrestin2
33.33	Single	8ZYU	SBI-553	8ZYU-NTS₁-Neurotensin-(8-13)-SBI-553-Arrestin2
31.58	Single	8JPC	SBI-553; GDP; Mg	8JPC-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
28.57	Single	8JPB	SBI-553; GDP; Mg	8JPB-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
27.27	Single	8ZYY	SBI-553	8ZYY-NTS₁-Neurotensin-(8-13)-SBI-553-Arrestin2
21.74	Single	8JR9	PCO371	8JR9-PTH1-PCO371-chim(NtGi1-Gs)/β1/γ2
21.74	Single	8TB7	PubChem 168510218	8TB7-GPR61-PubChem 168510218
20.00	Single	3VG9	Antibody	3VG9-A_2A-ZM-241385-Antibody
19.05	Single	7E2Y	PtdIns4P	7E2Y-5-HT_1A-Serotonin-PtdIns4P-Gi1/β1/γ2
18.18	Single	3VGA	Antibody	3VGA-A_2A-ZM-241385-Antibody
18.18	Single	8GW8	PCO371	8GW8-PTH1-PCO371-Gs/β1/γ2
15.79	Single	9DYD	PtdIns4P	9DYD-5-HT_1A-Asenapine-PtdIns4P-Go/β1/γ2
15.00	Single	9DYE	PtdIns4P	9DYE-5-HT_1A-Buspirone-PtdIns4P-Go/β1/γ2
14.29	Single	9KVH	PtdIns4P	9KVH-5-HT_1A-Cinobufotenine-PtdIns4P-Gi1/β1/γ2
13.64	Single	5XF1	NNC0640	5XF1-Glucagon-NNC0640
13.64	Single	7E2Z	PtdIns4P	7E2Z-5-HT_1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2
13.64	Single	8FYE	PtdIns4P	8FYE-5-HT_1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1
13.64	Single	8FYT	PtdIns4P	8FYT-5-HT_1A-LSD-PtdIns4P-Gi1/β1/γ1
13.04	Single	8FYL	PtdIns4P	8FYL-5-HT_1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
13.04	Single	8FYX	PtdIns4P	8FYX-5-HT_1A-Buspirone-PtdIns4P-Gi1/β1/γ1
12.00	Single	9DYF	PtdIns4P	9DYF-5-HT_1A-Asenapine-PtdIns4P-Gi1/β1/γ2
10.53	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
10.53	Single	8JT6	PtdIns4P	8JT6-5-HT_1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2
10.00	Single	5VEX	NNC0640	5VEX-GLP-1-NNC0640
10.00	Single	6KK7	PF-06372222	6KK7-GLP-1-PF-06372222
9.52	Single	5VEW	PF-06372222	5VEW-GLP-1-PF-06372222
9.52	Single	6KJV	PF-06372222	6KJV-GLP-1-PF-06372222
9.52	Single	6KK1	PF-06372222	6KK1-GLP-1-PF-06372222
9.52	Single	9MD1	PtdIns4P	9MD1-5-HT_1A-Buspirone-PtdIns4P-Gz/β1/γ2
9.09	Single	5XEZ	NNC0640	5XEZ-Glucagon-NNC0640
8.70	Single	7E2X	PtdIns4P	7E2X-5-HT_1A-PtdIns4P-Gi1/β1/γ2
8.70	Single	8XQL	Aristolochic acid A	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.70	Single	9KVG	PtdIns4P	9KVG-5-HT_1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ2
8.33	Single	8FY8	PtdIns4P	8FY8-5-HT_1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1
8.00	Single	8J20	AR420626	8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
7.41	Single	6LN2	PF-06372222	6LN2-GLP-1-PF-06372222
5.88	Single	9KVI	PtdIns4P	9KVI-5-HT_1A-Bufotenin-PtdIns4P-Gi1/β1/γ2
5.26	Single	7EB2	rac-BHFF	7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
5.00	Single	8XQP	Aristolochic acid A	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.00	Single	8Y6W	4-CMTB	8Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
4.76	Single	7CA3	rac-BHFF	7CA3-GABA_B1, GABA_B2-rac-BHFF
4.55	Single	4K5Y	CP-376395	4K5Y-CRF₁-CP-376395
4.55	Single	7C7Q	BHFF	7C7Q-GABA_B1, GABA_B2-Baclofen-BHFF
4.55	Single	7EJX	(1R;2R)-2-PCCA	7EJX-GPR88-(1R;2R)-2-PCCA-Gi1/β1/γ2
4.55	Single	8XQN	Aristolochic acid A	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.55	Single	8XQR	Flufenamic acid	8XQR-TAS2R14-Flufenamic acid-Gt3/β1/γ1
4.55	Single	9CLW	4-CMTB	9CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.35	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
4.35	Single	8XQO	Aristolochic acid A	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.35	Single	8XQS	Flufenamic acid	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
4.17	Single	4Z9G	CP-376395	4Z9G-CRF₁-CP-376395
4.17	Single	8GTI	BMK-C205	8GTI-CRF₁-BMK-C205
4.00	Single	8GTG	BMK-I152	8GTG-CRF₁-BMK-I152
3.70	Single	8GTM	BMK-C203	8GTM-CRF₁-BMK-C203

PDB Summary
PDB	5LWE
Class	A
SubFamily	Protein
Type	Chemokine
SubType	CCR9
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	Vercirnon
Protein Partners	-
PDB Resolution	2.8
Date	2016-12-07
D.O.I.	doi.org/10.1038/nature20606

Net Summary
I_min	3.21
Number of Linked Nodes	254
Number of Links	279
Number of Hubs	35
Number of Links mediated by Hubs	134
Number of Communities	6
Number of Nodes involved in Communities	47
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	55
Number Of Links MetaPath	54
Number of Shortest Paths	60163
Length Of Smallest Path	3
Average Path Length	12.5792
Length of Longest Path	24
Minimum Path Strength	1.305
Average Path Strength	6.55975
Maximum Path Strength	20.735
Minimum Path Correlation	0.7
Average Path Correlation	0.935865
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.88235
Average % Of Corr. Nodes	56.0624
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.6812
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• chemotaxis • response to stimulus • taxis • response to chemical • response to external stimulus • locomotion • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cell chemotaxis • cellular response to stimulus • cellular response to chemical stimulus • cell migration • cellular process • cell motility • gamma-delta intraepithelial T cell differentiation • developmental process • multicellular organismal process • cellular developmental process • gamma-delta T cell activation • hemopoiesis • cell activation • cell development • mononuclear cell differentiation • lymphocyte activation • lymphocyte differentiation • leukocyte activation • gamma-delta T cell differentiation • CD8-positive, gamma-delta intraepithelial T cell differentiation • T cell activation • immune system process • cell differentiation • anatomical structure development • T cell differentiation • leukocyte differentiation • immune response • defense response • response to stress • cellular defense response • regulation of biological process • regulation of cellular process • signaling • G protein-coupled receptor signaling pathway • signal transduction • cell communication • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	79K
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	79K
Name	Vercirnon
Synonyms	Vercirnon
Identifier
Formula	C22 H21 Cl N2 O4 S
Molecular Weight	444.931
SMILES
PubChem	10343454
Formal Charge	0
Total Atoms	51
Total Chiral Atoms	0
Total Bonds	53
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P51686
Sequence	>5LWE_Chain_R N F E D F Y C E K N N V R Q F A S H F L P P L Y W L V F I V G A L G N S L V I L V Y W Y C A R A K T A T D M F L L N L A I A D L L F L V T L P F W A I A A A T F M C K V V N S M Y K M N F Y S C V L L I M C I C V D R Y I A I A Q A M R A H T W R E K R L L Y S K M V C F T I W V L A A A L C I P E I L T K L K S A V L A L K V I L G F F L P F V V M A C C Y T I I I H T L I Q A K K S S K H K A L K A T I T V L T V F V L S Q F P Y N C I L L V Q T I D A Y A M F I S N C A V S T A I D I C F Q V T Q A I A F F H S C L N P V L Y V F V G E R F R R D L V K T L K N L G A I S Q A A A H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5LWE	A	Protein	Chemokine	CCR9	Homo sapiens	-	Vercirnon	-	2.8	2016-12-07	doi.org/10.1038/nature20606

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.