psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D35	R:R:N32	9.42	No	No	0	7	7
2	R:R:D35	R:R:N41	4.04	No	No	0	7	3
3	R:R:C289	R:R:C38	7.28	No	No	0	6	7
4	R:R:D296	R:R:R44	3.57	No	No	0	4	4
5	R:R:Q300	R:R:R44	3.5	No	No	0	4	4
6	R:R:A47	R:R:Q300	4.55	No	No	0	5	4
7	R:R:F50	R:R:L54	7.31	No	No	0	6	5
8	R:R:L51	R:R:Y55	9.38	No	Yes	0	5	8
9	R:R:P52	R:R:P53	5.84	Yes	No	0	5	5
10	R:R:A108	R:R:P52	3.74	No	Yes	0	5	5
11	R:R:W104	R:R:Y55	5.79	Yes	Yes	1	6	8
12	R:R:Q303	R:R:Y55	5.64	Yes	Yes	1	6	8
13	R:R:F307	R:R:Y55	14.44	Yes	Yes	1	7	8
14	R:R:P102	R:R:W56	5.4	No	No	0	8	4
15	R:R:A105	R:R:W56	7.78	No	No	0	6	4
16	R:R:F308	R:R:V58	5.24	Yes	No	3	6	7
17	R:R:C311	R:R:V58	3.42	No	No	3	8	7
18	R:R:F59	R:R:I60	3.77	No	No	0	7	6
19	R:R:F59	R:R:P102	14.45	No	No	0	7	8
20	R:R:C311	R:R:V61	5.12	No	No	0	8	6
21	R:R:G62	R:R:L98	3.42	No	No	0	8	6
22	R:R:G65	R:R:P314	4.06	No	No	0	8	9
23	R:R:A91	R:R:N66	4.69	No	Yes	0	9	9
24	R:R:D94	R:R:N66	10.77	No	Yes	0	9	9
25	R:R:L95	R:R:N66	5.49	No	Yes	0	7	9
26	R:R:N66	R:R:P314	6.52	Yes	No	0	9	9
27	R:R:L328	R:R:L68	4.15	No	No	2	6	6
28	R:R:A91	R:R:V69	3.39	No	No	0	9	8
29	R:R:P314	R:R:V69	3.53	No	No	0	9	8
30	R:R:I70	R:R:L88	4.28	No	No	0	7	5
31	R:R:L71	R:R:Y75	3.52	No	Yes	4	4	5
32	R:R:L335	R:R:L71	4.15	No	No	4	2	4
33	R:R:F324	R:R:V72	5.24	Yes	Yes	2	8	7
34	R:R:T331	R:R:V72	7.93	No	Yes	0	4	7
35	R:R:W74	R:R:Y73	13.5	No	Yes	0	4	7
36	R:R:K80	R:R:Y73	23.89	No	Yes	0	7	7
37	R:R:L88	R:R:Y73	17.58	No	Yes	0	5	7
38	R:R:Y73	W:W:?1	4.48	Yes	Yes	0	7	0
39	R:R:T331	R:R:Y75	3.75	No	Yes	0	4	5
40	R:R:L335	R:R:Y75	10.55	No	Yes	4	2	5
41	R:R:C76	R:R:R78	4.18	No	Yes	2	6	6
42	R:R:C76	R:R:K80	4.85	No	No	0	6	7
43	R:R:C76	R:R:D327	6.22	No	No	2	6	4
44	R:R:D84	R:R:R78	10.72	No	Yes	2	8	6
45	R:R:R323	R:R:R78	14.93	No	Yes	2	6	6
46	R:R:D327	R:R:R78	15.48	No	Yes	2	4	6
47	R:R:R78	W:W:?1	3.32	Yes	Yes	2	6	0
48	R:R:D84	R:R:T81	10.12	No	No	2	8	7
49	R:R:T81	W:W:?1	4.83	No	Yes	2	7	0
50	R:R:A82	R:R:D143	6.18	No	Yes	0	6	8
51	R:R:A82	R:R:S165	3.42	No	Yes	0	6	7
52	R:R:D143	R:R:T83	7.23	Yes	No	2	8	8
53	R:R:R144	R:R:T83	11.64	Yes	No	2	9	8
54	R:R:T83	W:W:?1	7.25	No	Yes	2	8	0
55	R:R:D84	W:W:?1	14.09	No	Yes	2	8	0
56	R:R:M85	R:R:N89	5.61	Yes	No	5	7	9
57	R:R:M85	R:R:S165	6.13	Yes	Yes	0	7	7
58	R:R:K166	R:R:M85	5.76	No	Yes	0	3	7
59	R:R:C169	R:R:M85	4.86	No	Yes	5	7	7
60	R:R:C139	R:R:F86	11.17	No	Yes	0	7	7
61	R:R:F86	R:R:I140	5.02	Yes	No	0	7	8
62	R:R:F86	R:R:S165	5.28	Yes	Yes	0	7	7
63	R:R:F86	R:R:V168	3.93	Yes	No	0	7	6
64	R:R:L87	R:R:Y317	5.86	No	Yes	2	8	9
65	R:R:L87	W:W:?1	15.13	No	Yes	2	8	0
66	R:R:I92	R:R:L88	4.28	No	No	0	6	5
67	R:R:C169	R:R:N89	11.02	No	No	5	7	9
68	R:R:N89	R:R:W173	7.91	No	No	0	9	9
69	R:R:L136	R:R:L90	4.15	No	No	0	8	9
70	R:R:I92	R:R:W173	3.52	No	No	0	6	9
71	R:R:D94	R:R:N129	5.39	No	Yes	1	9	8
72	R:R:D94	R:R:S310	5.89	No	Yes	1	9	9
73	R:R:F97	R:R:L101	4.87	Yes	No	0	7	8
74	R:R:F97	R:R:Y126	4.13	Yes	Yes	1	7	7
75	R:R:F97	R:R:N129	4.83	Yes	Yes	1	7	8
76	R:R:F307	R:R:F97	13.93	Yes	Yes	1	7	7
77	R:R:F97	R:R:S310	7.93	Yes	Yes	1	7	9
78	R:R:L98	R:R:S310	6.01	No	Yes	0	6	9
79	R:R:T100	R:R:V122	4.76	No	No	0	7	5
80	R:R:F103	R:R:M118	7.46	No	Yes	0	7	6
81	R:R:M118	R:R:W104	3.49	Yes	Yes	0	6	6
82	R:R:V122	R:R:W104	11.03	No	Yes	0	5	6
83	R:R:Q303	R:R:W104	8.76	Yes	Yes	1	6	6
84	R:R:M118	R:R:V121	4.56	Yes	No	0	6	5
85	R:R:I184	R:R:S124	4.64	No	No	0	5	5
86	R:R:K127	R:R:Y126	3.58	No	Yes	0	5	7
87	R:R:F130	R:R:Y126	6.19	Yes	Yes	1	8	7
88	R:R:Q267	R:R:Y126	9.02	Yes	Yes	1	9	7
89	R:R:Y126	R:R:Y270	12.91	Yes	Yes	1	7	7
90	R:R:N271	R:R:Y126	5.81	No	Yes	1	8	7
91	R:R:A306	R:R:Y126	4	No	Yes	1	8	7
92	R:R:F307	R:R:Y126	6.19	Yes	Yes	1	7	7
93	R:R:K127	R:R:Y131	10.75	No	No	0	5	7
94	R:R:E183	R:R:K127	12.15	No	No	0	4	5
95	R:R:C180	R:R:M128	3.24	No	No	0	6	5
96	R:R:C133	R:R:N129	4.72	No	Yes	0	9	8
97	R:R:N129	R:R:S310	4.47	Yes	Yes	1	8	9
98	R:R:F130	R:R:Y131	4.13	Yes	No	0	8	7
99	R:R:F130	R:R:V134	5.24	Yes	No	0	8	8
100	R:R:F130	R:R:P226	5.78	Yes	No	0	8	9
101	R:R:F130	R:R:F263	3.22	Yes	Yes	1	8	9
102	R:R:F130	R:R:Q267	8.2	Yes	Yes	1	8	9
103	R:R:F130	R:R:N271	14.5	Yes	No	1	8	8
104	R:R:L179	R:R:Y131	11.72	No	No	0	6	7
105	R:R:A176	R:R:S132	3.42	No	No	0	8	7
106	R:R:C133	R:R:F263	5.59	No	Yes	0	9	9
107	R:R:V134	R:R:V229	3.21	No	No	0	8	7
108	R:R:I172	R:R:L135	9.99	No	No	0	7	6
109	R:R:I172	R:R:L136	4.28	No	No	0	7	8
110	R:R:F263	R:R:I137	5.02	Yes	No	0	9	8
111	R:R:M138	R:R:V229	4.56	No	No	0	7	7
112	R:R:C233	R:R:M138	3.24	No	No	0	7	7
113	R:R:C141	R:R:C233	3.64	No	No	0	9	7
114	R:R:C141	R:R:I236	3.27	No	No	0	9	3
115	R:R:C141	R:R:I237	3.27	No	No	0	9	8
116	R:R:D143	R:R:R144	5.96	Yes	Yes	2	8	9
117	R:R:D143	R:R:R161	11.91	Yes	No	0	8	7
118	R:R:A147	R:R:R144	5.53	No	Yes	0	8	9
119	R:R:R144	R:R:T256	6.47	Yes	No	2	9	7
120	R:R:R144	W:W:?1	11.95	Yes	Yes	2	9	0
121	R:R:A149	R:R:Y145	4	No	Yes	0	7	8
122	R:R:Q150	R:R:Y145	4.51	No	Yes	0	7	8
123	R:R:T240	R:R:Y145	9.99	No	Yes	0	5	8
124	R:R:Q243	R:R:Y145	10.15	No	Yes	0	4	8
125	R:R:I146	R:R:R153	3.76	No	No	0	5	5
126	R:R:A252	R:R:I148	3.25	No	No	0	8	8
127	R:R:I148	R:R:L253	4.28	No	No	0	8	6
128	R:R:Q150	R:R:R153	3.5	No	No	0	7	5
129	R:R:R153	R:R:W157	14.99	No	No	0	5	4
130	R:R:A154	R:R:R161	5.53	No	No	0	5	7
131	R:R:H155	R:R:R158	15.8	No	No	0	5	4
132	R:R:T156	R:R:W157	12.13	No	No	0	5	4
133	R:R:K160	R:R:W157	6.96	No	No	0	6	4
134	R:R:E159	R:R:K160	13.5	No	No	0	3	6
135	R:R:F170	R:R:V174	5.24	No	No	0	4	4
136	R:R:L179	R:R:L221	4.15	No	No	0	6	5
137	R:R:I181	R:R:P182	5.08	No	No	0	4	7
138	R:R:K218	R:R:V214	6.07	No	No	0	5	5
139	R:R:L215	R:R:Y282	12.89	No	Yes	0	5	1
140	R:R:K218	R:R:Y282	3.58	No	Yes	0	5	1
141	R:R:F223	R:R:L275	12.18	Yes	No	0	8	6
142	R:R:F223	R:R:T278	3.89	Yes	No	0	8	5
143	R:R:F224	R:R:V228	7.87	No	No	0	5	3
144	R:R:M230	R:R:V264	6.09	No	No	0	8	5
145	R:R:C233	R:R:L260	6.35	No	No	0	7	8
146	R:R:L260	R:R:Y234	15.24	No	No	0	8	8
147	R:R:T261	R:R:Y234	6.24	No	No	0	5	8
148	R:R:V264	R:R:Y234	3.79	No	No	0	5	8
149	R:R:I237	R:R:I257	4.42	No	No	0	8	5
150	R:R:A244	R:R:K249	4.82	No	No	0	6	7
151	R:R:K246	R:R:S248	4.59	No	No	0	4	4
152	R:R:H250	R:R:K249	9.17	No	No	0	6	7
153	R:R:E322	R:R:K251	6.75	No	No	0	4	7
154	R:R:L253	R:R:T256	4.42	No	No	0	6	7
155	R:R:K254	R:R:V320	6.07	No	No	0	5	7
156	R:R:A255	W:W:?1	8.61	No	Yes	0	8	0
157	R:R:T256	W:W:?1	7.25	No	Yes	2	7	0
158	R:R:T258	R:R:V320	9.52	No	No	0	6	7
159	R:R:N313	R:R:V259	5.91	No	No	0	9	8
160	R:R:V259	W:W:?1	4.07	No	Yes	0	8	0
161	R:R:H309	R:R:V262	5.54	Yes	No	0	9	7
162	R:R:L316	R:R:V262	5.96	No	No	0	8	7
163	R:R:F263	R:R:Q267	7.03	Yes	Yes	1	9	9
164	R:R:F263	R:R:H309	9.05	Yes	Yes	1	9	9
165	R:R:Q267	R:R:S266	7.22	Yes	No	1	9	9
166	R:R:H309	R:R:S266	11.16	Yes	No	1	9	9
167	R:R:A306	R:R:Q267	4.55	No	Yes	1	8	9
168	R:R:H309	R:R:Q267	3.71	Yes	Yes	1	9	9
169	R:R:F268	R:R:P269	4.33	No	No	0	6	9
170	R:R:C272	R:R:F268	8.38	No	No	0	7	6
171	R:R:P269	R:R:T302	3.5	No	No	0	9	6
172	R:R:L274	R:R:Y270	16.41	No	Yes	0	6	7
173	R:R:F299	R:R:Y270	6.19	Yes	Yes	1	4	7
174	R:R:T302	R:R:Y270	6.24	No	Yes	0	6	7
175	R:R:Q303	R:R:Y270	16.91	Yes	Yes	1	6	7
176	R:R:A306	R:R:Y270	4	No	Yes	1	8	7
177	R:R:C298	R:R:I273	3.27	No	No	0	5	5
178	R:R:I273	R:R:T302	4.56	No	No	0	5	6
179	R:R:I279	R:R:L275	4.28	No	No	0	4	6
180	R:R:F299	R:R:Q277	12.88	Yes	No	0	4	4
181	R:R:F285	R:R:I279	3.77	Yes	No	0	1	4
182	R:R:D280	R:R:F285	15.52	No	Yes	6	2	1
183	R:R:D280	R:R:I286	13.99	No	Yes	6	2	2
184	R:R:F285	R:R:I286	5.02	Yes	Yes	6	1	2
185	R:R:I286	R:R:V291	4.61	Yes	No	0	2	1
186	R:R:N288	R:R:V291	5.91	No	No	0	3	1
187	R:R:F299	R:R:Q300	3.51	Yes	No	0	4	4
188	R:R:F299	R:R:Q303	5.86	Yes	Yes	1	4	6
189	R:R:F307	R:R:Q303	14.05	Yes	Yes	1	7	6
190	R:R:C311	R:R:F308	4.19	No	Yes	3	8	6
191	R:R:F308	R:R:L312	7.31	Yes	No	0	6	7
192	R:R:H309	R:R:N313	5.1	Yes	No	0	9	9
193	R:R:N313	R:R:Y317	10.47	No	Yes	0	9	9
194	R:R:F324	R:R:Y317	5.16	Yes	Yes	2	8	9
195	R:R:Y317	W:W:?1	10.89	Yes	Yes	2	9	0
196	R:R:G321	W:W:?1	3.74	No	Yes	0	8	0
197	R:R:D327	R:R:R323	5.96	No	No	2	4	6
198	R:R:R323	W:W:?1	14.6	No	Yes	2	6	0
199	R:R:F324	W:W:?1	11.31	Yes	Yes	2	8	0
200	R:R:K333	R:R:V329	4.55	No	No	0	5	5
201	R:R:C133	R:R:L90	3.17	No	No	0	9	9
202	R:R:F33	R:R:Y37	3.09	No	No	0	4	2
203	R:R:F36	R:R:Y37	3.09	No	No	0	3	2
204	R:R:I297	R:R:V43	3.07	No	No	0	1	3
205	R:R:I148	R:R:T240	3.04	No	No	0	8	5
206	R:R:A252	R:R:E322	3.02	No	No	0	8	4
207	R:R:M125	R:R:T100	3.01	No	No	0	5	7
208	R:R:F223	R:R:G222	3.01	Yes	No	0	8	6
209	R:R:L95	R:R:S67	3	No	No	0	7	4
210	R:R:L162	R:R:S165	3	No	Yes	0	3	7
211	R:R:L57	R:R:V61	2.98	No	No	0	4	6
212	R:R:L101	R:R:V58	2.98	No	No	0	8	7
213	R:R:L68	R:R:V72	2.98	No	Yes	2	6	7
214	R:R:L328	R:R:V72	2.98	No	Yes	2	6	7
215	R:R:L215	R:R:V219	2.98	No	No	0	5	6
216	R:R:N288	R:R:S287	2.98	No	No	0	3	1
217	R:R:L316	R:R:T258	2.95	No	No	0	8	6
218	R:R:L265	R:R:T261	2.95	No	No	0	5	5
219	R:R:I238	R:R:I242	2.94	No	No	0	5	4
220	R:R:M125	R:R:M128	2.89	No	No	0	5	5
221	R:R:L96	R:R:M125	2.83	No	No	0	7	5
222	R:R:I338	R:R:N334	2.83	No	No	0	3	4
223	R:R:K249	R:R:L241	2.82	No	No	0	7	8
224	R:R:L135	R:R:L175	2.77	No	No	0	6	4
225	R:R:L241	R:R:L253	2.77	No	No	0	8	6
226	R:R:H239	R:R:T235	2.74	No	No	0	3	4
227	R:R:I295	R:R:Q277	2.74	No	No	0	4	4
228	R:R:A281	R:R:Y282	2.67	No	Yes	0	3	1
229	R:R:F319	R:R:V315	2.62	No	No	0	6	6
230	R:R:F324	R:R:V318	2.62	Yes	No	0	8	7
231	R:R:A93	R:R:W173	2.59	No	No	0	8	9
232	R:R:F308	R:R:L54	2.44	Yes	No	0	6	5
233	R:R:F223	R:R:L274	2.44	Yes	No	0	8	6
234	R:R:I338	R:R:Y75	2.42	No	Yes	0	3	5
235	R:R:K211	R:R:Y282	2.39	No	Yes	0	3	1
236	R:R:A109	R:R:P52	1.87	No	Yes	0	4	5
237	R:R:G336	R:R:S339	1.86	No	No	0	4	5
238	R:R:A109	R:R:S48	1.71	No	No	0	4	6
239	R:R:G65	R:R:L64	1.71	No	No	0	8	5
240	R:R:A93	R:R:S132	1.71	No	No	0	8	7
241	R:R:C232	R:R:V228	1.71	No	No	0	5	3
242	R:R:C289	R:R:T293	1.69	No	No	0	6	2
243	R:R:A290	R:R:T293	1.68	No	No	0	1	2
244	R:R:L51	R:R:P52	1.64	No	Yes	0	5	5
245	R:R:L101	R:R:P102	1.64	No	No	0	8	8
246	R:R:L225	R:R:P226	1.64	No	No	0	6	9
247	R:R:A283	R:R:I279	1.62	No	No	0	3	4
248	R:R:A177	R:R:M128	1.61	No	No	0	3	5
249	R:R:T100	R:R:V99	1.59	No	No	0	7	5
250	R:R:A304	R:R:L54	1.58	No	No	0	5	5
251	R:R:A63	R:R:L95	1.58	No	No	0	6	7
252	R:R:C119	R:R:N123	1.57	No	No	0	9	5
253	R:R:A77	R:R:N334	1.56	No	No	0	6	4
254	R:R:I305	R:R:S266	1.55	No	No	0	8	9
255	R:R:I286	R:R:S292	1.55	Yes	No	0	2	3
256	R:R:I146	R:R:V142	1.54	No	No	0	5	6
257	R:R:I236	R:R:V142	1.54	No	No	0	3	6
258	R:R:I297	R:R:V301	1.54	No	No	0	1	5
259	R:R:I305	R:R:V301	1.54	No	No	0	8	5
260	R:R:M152	R:R:T156	1.51	No	No	0	6	5
261	R:R:K209	R:R:T208	1.5	No	No	0	1	1
262	R:R:L210	R:R:V214	1.49	No	No	0	3	5
263	R:R:L275	R:R:V219	1.49	No	No	0	6	6
264	R:R:I181	R:R:I184	1.47	No	No	0	4	5
265	R:R:L163	R:R:M167	1.41	No	No	0	4	2
266	R:R:N41	R:R:Q45	1.32	No	No	0	3	2
267	R:R:C119	R:R:W104	1.31	No	Yes	0	9	6
268	R:R:E183	R:R:N123	1.31	No	No	0	4	5
269	R:R:F227	R:R:V228	1.31	No	No	0	7	3
270	R:R:F285	R:R:V276	1.31	Yes	No	0	1	5
271	R:R:F319	R:R:V318	1.31	No	No	0	6	7
272	R:R:F319	R:R:V320	1.31	No	No	0	6	7
273	R:R:D35	R:R:E34	1.3	No	No	0	7	6
274	R:R:F224	R:R:I220	1.26	No	No	0	5	5
275	R:R:F117	R:R:M118	1.24	No	Yes	0	3	6
276	R:R:H239	R:R:Q243	1.24	No	No	0	3	4
277	R:R:M167	R:R:Y164	1.2	No	No	0	2	3
278	R:R:I106	R:R:W56	1.17	No	No	0	4	4
279	R:R:R158	R:R:R161	1.07	No	No	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P52	3.2725	4	0	5
2	R:R:Y55	8.8125	4	1	8
3	R:R:N66	6.8675	4	0	9
4	R:R:V72	4.7825	4	2	7
5	R:R:Y73	14.8625	4	0	7
6	R:R:Y75	5.06	4	4	5
7	R:R:R78	9.726	5	2	6
8	R:R:M85	5.59	4	5	7
9	R:R:F86	6.35	4	0	7
10	R:R:F97	7.138	5	1	7
11	R:R:W104	6.076	5	1	6
12	R:R:M118	4.1875	4	0	6
13	R:R:Y126	6.47875	8	1	7
14	R:R:N129	4.8525	4	1	8
15	R:R:F130	6.75143	7	1	8
16	R:R:D143	7.82	4	2	8
17	R:R:R144	8.31	5	2	9
18	R:R:Y145	7.1625	4	0	8
19	R:R:S165	4.4575	4	0	7
20	R:R:F223	5.38	4	0	8
21	R:R:F263	5.982	5	1	9
22	R:R:Q267	6.62167	6	1	9
23	R:R:Y270	10.4433	6	1	7
24	R:R:Y282	5.3825	4	0	1
25	R:R:F285	6.405	4	6	1
26	R:R:I286	6.2925	4	6	2
27	R:R:F299	7.11	4	1	4
28	R:R:Q303	10.244	5	1	6
29	R:R:F307	12.1525	4	1	7
30	R:R:F308	4.795	4	3	6
31	R:R:H309	6.912	5	1	9
32	R:R:S310	6.075	4	1	9
33	R:R:Y317	8.095	4	2	9
34	R:R:F324	6.0825	4	2	8
35	W:W:?1	8.68	14	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Y126	R:R:Y270	35.3365	12.91	Yes	Yes	1	7	7
2	R:R:F97	R:R:Y126	18.8565	4.13	Yes	Yes	1	7	7
3	R:R:F97	R:R:L101	14.0457	4.87	Yes	No	0	7	8
4	R:R:F307	R:R:Q303	11.4327	14.05	Yes	Yes	1	7	6
5	R:R:Q303	R:R:W104	25.6651	8.76	Yes	Yes	1	6	6
6	R:R:D94	R:R:N129	10.3785	5.39	No	Yes	1	9	8
7	R:R:D94	R:R:N66	13.2466	10.77	No	Yes	0	9	9
8	R:R:Q267	R:R:Y126	54.5846	9.02	Yes	Yes	1	9	7
9	R:R:H309	R:R:Q267	83.0599	3.71	Yes	Yes	1	9	9
10	R:R:H309	R:R:N313	100	5.1	Yes	No	0	9	9
11	R:R:N313	R:R:Y317	54.6609	10.47	No	Yes	0	9	9
12	R:R:A306	R:R:Y270	24.8186	4	No	Yes	1	8	7
13	R:R:A306	R:R:Q267	25.2208	4.55	No	Yes	1	8	9
14	R:R:N313	R:R:V259	45.1577	5.91	No	No	0	9	8
15	R:R:V259	W:W:?1	44.7503	4.07	No	Yes	0	8	0
16	R:R:Y73	W:W:?1	17.1293	4.48	Yes	Yes	0	7	0
17	R:R:L88	R:R:Y73	12.918	17.58	No	Yes	0	5	7
18	R:R:Y317	W:W:?1	44.7266	10.89	Yes	Yes	2	9	0
19	R:R:A82	R:R:D143	28.1467	6.18	No	Yes	0	6	8
20	R:R:D143	R:R:T83	20.3654	7.23	Yes	No	2	8	8
21	R:R:T83	W:W:?1	21.6719	7.25	No	Yes	2	8	0
22	R:R:D143	R:R:R144	21.6193	5.96	Yes	Yes	2	8	9
23	R:R:R144	W:W:?1	22.9784	11.95	Yes	Yes	2	9	0
24	R:R:A82	R:R:S165	25.3707	3.42	No	Yes	0	6	7
25	R:R:I92	R:R:L88	10.0683	4.28	No	No	0	6	5
26	R:R:F86	R:R:S165	11.3644	5.28	Yes	Yes	0	7	7
27	R:R:F130	R:R:Y126	11.622	6.19	Yes	Yes	1	8	7
28	R:R:F130	R:R:F263	10.765	3.22	Yes	Yes	1	8	9
29	R:R:C133	R:R:F263	13.3833	5.59	No	Yes	0	9	9
30	R:R:V122	R:R:W104	20.6283	11.03	No	Yes	0	5	6
31	R:R:T100	R:R:V122	18.0678	4.76	No	No	0	7	5
32	R:R:M118	R:R:W104	10.3549	3.49	Yes	Yes	0	6	6
33	R:R:M125	R:R:T100	12.9311	3.01	No	No	0	5	7
34	R:R:F130	R:R:V134	20.3523	5.24	Yes	No	0	8	8
35	R:R:V134	R:R:V229	19.1299	3.21	No	No	0	8	7
36	R:R:M138	R:R:V229	17.9154	4.56	No	No	0	7	7
37	R:R:C233	R:R:M138	16.7482	3.24	No	No	0	7	7
38	R:R:D143	R:R:R161	11.3959	11.91	Yes	No	0	8	7
39	R:R:T256	W:W:?1	22.5789	7.25	No	Yes	2	7	0
40	R:R:T240	R:R:Y145	10.234	9.99	No	Yes	0	5	8
41	R:R:I148	R:R:T240	11.4905	3.04	No	No	0	8	5
42	R:R:I148	R:R:L253	16.5142	4.28	No	No	0	8	6
43	R:R:L253	R:R:T256	22.7445	4.42	No	No	0	6	7
44	R:R:L274	R:R:Y270	30.1656	16.41	No	Yes	0	6	7
45	R:R:F223	R:R:L274	28.9012	2.44	Yes	No	0	8	6
46	R:R:F223	R:R:L275	25.0868	12.18	Yes	No	0	8	6
47	R:R:L275	R:R:V219	10.7781	1.49	No	No	0	6	6
48	R:R:I279	R:R:L275	13.4437	4.28	No	No	0	4	6
49	R:R:F285	R:R:I279	10.7781	3.77	Yes	No	0	1	4
50	R:R:F307	R:R:Y55	14.6477	14.44	Yes	Yes	1	7	8
51	R:R:W104	R:R:Y55	10.0289	5.79	Yes	Yes	1	6	8
52	R:R:F307	R:R:Y126	20.9989	6.19	Yes	Yes	1	7	7
53	R:R:Q303	R:R:Y270	17.3817	16.91	Yes	Yes	1	6	7
54	R:R:F263	R:R:H309	18.5147	9.05	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F324	R:R:V72	5.24	2	Yes	Yes	8	7	1	2
R:R:W74	R:R:Y73	13.5	0	No	Yes	4	7	2	1
R:R:K80	R:R:Y73	23.89	0	No	Yes	7	7	2	1
R:R:L88	R:R:Y73	17.58	0	No	Yes	5	7	2	1
R:R:Y73	W:W:?1	4.48	0	Yes	Yes	7	0	1	0
R:R:C76	R:R:R78	4.18	2	No	Yes	6	6	2	1
R:R:C76	R:R:K80	4.85	2	No	No	6	7	2	2
R:R:C76	R:R:D327	6.22	2	No	No	6	4	2	2
R:R:D84	R:R:R78	10.72	2	No	Yes	8	6	1	1
R:R:R323	R:R:R78	14.93	2	No	Yes	6	6	1	1
R:R:D327	R:R:R78	15.48	2	No	Yes	4	6	2	1
R:R:R78	W:W:?1	3.32	2	Yes	Yes	6	0	1	0
R:R:D84	R:R:T81	10.12	2	No	No	8	7	1	1
R:R:T81	W:W:?1	4.83	2	No	Yes	7	0	1	0
R:R:D143	R:R:T83	7.23	2	Yes	No	8	8	2	1
R:R:R144	R:R:T83	11.64	2	Yes	No	9	8	1	1
R:R:T83	W:W:?1	7.25	2	No	Yes	8	0	1	0
R:R:D84	W:W:?1	14.09	2	No	Yes	8	0	1	0
R:R:L87	R:R:Y317	5.86	2	No	Yes	8	9	1	1
R:R:L87	W:W:?1	15.13	2	No	Yes	8	0	1	0
R:R:D143	R:R:R144	5.96	2	Yes	Yes	8	9	2	1
R:R:A147	R:R:R144	5.53	0	No	Yes	8	9	2	1
R:R:R144	R:R:T256	6.47	2	Yes	No	9	7	1	1
R:R:R144	W:W:?1	11.95	2	Yes	Yes	9	0	1	0
R:R:L253	R:R:T256	4.42	0	No	No	6	7	2	1
R:R:A255	W:W:?1	8.61	0	No	Yes	8	0	1	0
R:R:T256	W:W:?1	7.25	2	No	Yes	7	0	1	0
R:R:N313	R:R:V259	5.91	0	No	No	9	8	2	1
R:R:V259	W:W:?1	4.07	0	No	Yes	8	0	1	0
R:R:N313	R:R:Y317	10.47	0	No	Yes	9	9	2	1
R:R:F324	R:R:Y317	5.16	2	Yes	Yes	8	9	1	1
R:R:Y317	W:W:?1	10.89	2	Yes	Yes	9	0	1	0
R:R:G321	W:W:?1	3.74	0	No	Yes	8	0	1	0
R:R:D327	R:R:R323	5.96	2	No	No	4	6	2	1
R:R:R323	W:W:?1	14.6	2	No	Yes	6	0	1	0
R:R:F324	W:W:?1	11.31	2	Yes	Yes	8	0	1	0
R:R:F324	R:R:V318	2.62	2	Yes	No	8	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Consensus	ccr9_off_allo	Other Ligand	5LWE-CCR9-Vercirnon
73.33	Single	6LFL	PubChem 153466996	6LFL-CXCR2-PubChem 153466996
57.14	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
47.06	Single	6QZH	HY-133073; Na	6QZH-CCR7-HY-133073; Na
47.06	Consensus	ccr7_off_allo	Other Ligand	6QZH-CCR7-HY-133073; Na
41.18	Single	5X7D	PubChem 129318963	5X7D-β₂-(S)-Carazolol-PubChem 129318963
38.89	Single	8JPF	PubChem 118610427	8JPF-NTS₁-Neurotensin-PubChem 118610427
36.84	Single	8JPC	PubChem 118610427; GDP; Mg	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
35.71	Consensus	ccr2_off_allo	Other Ligand	5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
30.00	Single	8FN0	PubChem 118610427	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
28.57	Single	8JPB	PubChem 118610427; GDP; Mg	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
27.78	Consensus	nts1_on_allo	Other Ligand	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
21.74	Single	8TB7	PubChem 168510218	8TB7-GPR61-PubChem 168510218
21.05	Single	6KK1	PubChem 68178630	6KK1-GLP-1-PubChem 68178630
20.00	Single	3VG9	Antibody	3VG9-A_2A-ZM241385-Antibody
19.05	Single	8JR9	PCO371	8JR9-PTH1-PCO371-chim(NtGi1-Gs)/&β;1/&γ;2
18.75	Single	3VGA	Antibody	3VGA-A_2A-ZM241385-Antibody
18.18	Single	8GW8	KHF	8GW8-PTH1-KHF-Gs/&β;1/&γ;2
13.04	Single	5XF1	NNC0640	5XF1-Glucagon-NNC0640
12.50	Single	4PXF	Octyl Beta-D-Glucopyranoside	4PXF-Rhodopsin-Octyl Beta-D-Glucopyranoside-Arrestin1_Finger_loop
10.00	Single	5VEX	NNC0640	5VEX-GLP-1-NNC0640
10.00	Single	6KK7	PubChem 68178630	6KK7-GLP-1-PubChem 68178630
9.52	Single	6KJV	PubChem 68178630	6KJV-GLP-1-PubChem 68178630
9.09	Single	5VEW	PF-06372222	5VEW-GLP-1-PF-06372222
8.70	Single	5XEZ	NNC0640	5XEZ-Glucagon-NNC0640
8.33	Consensus	ffa3_on_allo	Other Ligand	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
8.00	Single	6LN2	PubChem 68178630	6LN2-GLP-1-PubChem 68178630
8.00	Single	8J20	AR420626	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
5.26	Single	7EB2	rac-BHFF	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
5.26	Consensus	class-c_on	Other Ligand	gabab_on mglu_on
5.26	Consensus	gabab_on	Other Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
5.26	Consensus	gi_class-c	Other Ligand	gi_mglu gi_gaba
5.00	Consensus	gi_gaba	Other Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
4.76	Single	7CA3	rac-BHFF	7CA3-GABA_B1, GABA_B2-rac-BHFF
4.55	Single	4K5Y	CP-376395	4K5Y-CRF₁-CP-376395
4.55	Single	7C7Q	PubChem 7023848	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
4.35	Single	7EJX	(1R;2R)-2-PCCA	7EJX-GPR88-(1R;2R)-2-PCCA-Gi1/&β;1/&γ;2
4.17	Single	4Z9G	CP-376395	4Z9G-CRF₁-CP-376395
4.17	Single	8GTI	BMK-C205	8GTI-CRF₁-BMK-C205
4.00	Single	8GTG	BMK-I152	8GTG-CRF₁-BMK-I152
3.70	Single	8GTM	BMK-C203	8GTM-CRF₁-BMK-C203
3.57	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2

PDB Summary
PDB	5LWE
Class	A
SubFamily	Protein
Type	Chemokine
SubType	CCR9
Species	Homo sapiens
Ligand	-
Other Ligand(s)	Vercirnon
Protein Partners	-
PDB Resolution	2.8
Date	2016-12-07
D.O.I.	10.1038/nature20606

Net Summary
I_min	3.21
Number of Linked Nodes	254
Number of Links	279
Number of Hubs	35
Number of Links mediated by Hubs	134
Number of Communities	6
Number of Nodes involved in Communities	47
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	55
Number Of Links MetaPath	54
Number of Shortest Paths	60163
Length Of Smallest Path	3
Average Path Length	12.5792
Length of Longest Path	24
Minimum Path Strength	1.305
Average Path Strength	6.55975
Maximum Path Strength	20.735
Minimum Path Correlation	0.7
Average Path Correlation	0.935865
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.88235
Average % Of Corr. Nodes	56.0624
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.6812
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	79K
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	79K
Name	Vercirnon
Synonyms	Vercirnon
Identifier	4-~{tert}-butyl-~{N}-[4-chloranyl-2-(1-oxidanidylpyridin-1-ium-4-yl)carbonyl-phenyl]benzenesulfonamide
Formula	C22 H21 Cl N2 O4 S
Molecular Weight	444.931
SMILES	CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc2ccc(cc2C(=O)c3cc[n+](cc3)[O-])Cl
PubChem	10343454
Formal Charge	0
Total Atoms	51
Total Chiral Atoms	0
Total Bonds	53
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P51686
Sequence	>5LWE_Chain_R N F E D F Y C E K N N V R Q F A S H F L P P L Y W L V F I V G A L G N S L V I L V Y W Y C A R A K T A T D M F L L N L A I A D L L F L V T L P F W A I A A A T F M C K V V N S M Y K M N F Y S C V L L I M C I C V D R Y I A I A Q A M R A H T W R E K R L L Y S K M V C F T I W V L A A A L C I P E I L T K L K S A V L A L K V I L G F F L P F V V M A C C Y T I I I H T L I Q A K K S S K H K A L K A T I T V L T V F V L S Q F P Y N C I L L V Q T I D A Y A M F I S N C A V S T A I D I C F Q V T Q A I A F F H S C L N P V L Y V F V G E R F R R D L V K T L K N L G A I S Q A A A H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This network is also present in following consensuses:
	Id	Components
	ccr9_off_allo	5LWE-CCR9-Vercirnon

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5LWE	A	Protein	Chemokine	CCR9	Homo sapiens	-	Vercirnon	-	2.8	2016-12-07	10.1038/nature20606

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 5LWE.zip

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