Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 10.6871710
2R:R:L37 4.514137
3R:R:F43 5.84833618
4R:R:W51 10.594515
5R:R:P59 4.31415
6R:R:D67 6.47465
7R:R:L74 3.4175466
8R:R:E88 6.015435
9R:R:L93 7.28434
10R:R:Y99 9.2537
11R:R:L102 6.29537
12R:R:Y103 9.38536
13R:R:P106 5.24254216
14R:R:L109 5.4254135
15R:R:M110 5.37254137
16R:R:L111 5.0025436
17R:R:V118 3.7354228
18R:R:C119 4.3075438
19R:R:W129 7.71667636
20R:R:V133 3.192539
21R:R:Y136 5.71667617
22R:R:S140 3.29408
23R:R:P141 4.035407
24R:R:L143 3.868538
25R:R:F149 7.47167638
26R:R:L152 4.56286737
27R:R:F153 8.1254147
28R:R:R154 5.805439
29R:R:H156 6.915616
30R:R:P157 3.87833617
31R:R:T160 5.7125407
32R:R:H162 4.5515
33R:R:T165 6.245417
34R:R:R166 5.665417
35R:R:F173 9.42477
36R:R:W175 10.3233679
37R:R:R177 6.3625478
38R:R:L181 4.6025417
39R:R:Q182 6.154237
40R:R:Q183 5.56418
41R:R:F188 7.708516
42R:R:V192 6.7954236
43R:R:C199 4.1325407
44R:R:T208 4.792506
45R:R:F212 8.655417
46R:R:P216 8.442517
47R:R:R221 8.3654243
48R:R:L234 3.88406
49R:R:F235 6.94833618
50R:R:Y236 8.1825417
51R:R:L244 5.7325418
52R:R:C245 4.69419
53R:R:E246 8.48418
54R:R:Y248 7.646517
55R:R:Y253 5.655406
56R:R:V258 4.6575478
57R:R:W259 9.6275409
58R:R:F260 5.51607
59R:R:F261 7.286516
60R:R:W264 7.732514
61R:R:Y265 7.166516
62R:R:W269 6.31714719
63R:R:Y270 7.8475416
64R:R:C281 4.3975419
65R:R:M286 3.8475417
66R:R:H293 6.89515
67R:R:L294 4.7575476
68R:R:T296 5.18416
69R:R:W301 14.5325463
70R:R:Q303 6.6075414
71R:R:F317 6.6667
72R:R:L321 4.9475406
73R:R:N322 4.945413
74R:R:L325 4.595414
75R:R:Y337 9.462513
76R:R:P338 5.46415
77R:R:E343 8.335415
78R:R:L346 4.59416
79R:R:Y348 8.67333669
80R:R:D349 4.922509
81R:R:W352 7.504568
82R:R:S353 3.93254147
83R:R:F358 4.548336138
84R:R:L372 4.39754136
85R:R:F375 5.8475407
86R:R:Y377 9.6625438
87R:R:I386 4.625405
88R:R:M390 7.26254146
89R:R:F395 5.728509
90R:R:V398 5.7575467
91R:R:F404 5.135409
92R:R:D409 7.24437
93R:R:T414 5.655416
94R:R:Q415 7.068514
95R:R:E417 7.042515
96R:R:Q418 5.418579
97R:R:M419 6.906515
98R:R:I420 6.165407
99R:R:Y424 8.554513
100R:R:Y429 4.94614
101R:R:Y430 7.434516
102R:R:W439 7.914504
103R:R:W445 6.155878
104R:R:D453 7.4025479
105R:R:R462 10.7625494
106R:R:F489 4.6175406
107R:R:I499 5.35458
108R:R:S502 5.42559
109R:R:R529 11.3484
110R:R:Y536 4.966584
111R:R:G550 2.814279
112R:R:F551 6.5475459
113R:R:Y555 5.94286758
114R:R:M558 5.428558
115R:R:F559 5.87408
116R:R:K561 6.0625459
117R:R:W563 3.714307
118R:R:V565 5.125408
119R:R:D607 6.052509
120R:R:L609 5.084286
121R:R:F616 10.7625495
122R:R:K629 2.8625404
123R:R:E635 7.575487
124R:R:Y650 4.2775406
125R:R:K653 4.83409
126R:R:L657 5.472558
127R:R:F659 7.65254306
128R:R:F662 7.03409
129R:R:D677 6.198559
130R:R:V681 7.324558
131R:R:S684 3.36667658
132R:R:I685 5.33408
133R:R:V688 4.474558
134R:R:V689 4.3457
135R:R:T695 4.0525407
136R:R:D707 3.4925406
137R:R:F710 5.0354257
138R:R:F729 6.48559
139R:R:K732 5.785459
140S:S:Y32 9.9754155
141S:S:F36 4.97333637
142S:S:F37 8.46448
143S:S:Y39 6.9475405
144S:S:M53 6.345445
145S:S:S55 5.375448
146S:S:V56 3.7975408
147S:S:V63 5.1575406
148S:S:H66 4.89444
149S:S:M77 4.31647
150S:S:W79 8.1075443
151S:S:F93 5.69286738
152S:S:F94 6.97167638
153S:S:M97 10.045437
154S:S:P101 7.36754155
155S:S:K103 3.92254158
156S:S:V104 4.59436
157S:S:L106 4.875437
158S:S:F107 6.21648
159S:S:C111 4.13754109
160S:S:T112 7.726529
161S:S:V114 4.32754108
162S:S:T115 5.0975429
163S:S:D116 6.795428
164S:S:H124 6.6537
165S:S:W125 8.86429739
166S:S:Q129 6.335429
167S:S:Y132 6.99833649
168S:S:H136 13.255428
169S:S:P137 6.098528
170S:S:M138 5.975428
171S:S:F139 8.08333629
172S:S:F144 5.986528
173S:S:F147 7.925629
174S:S:F148 11.095407
175S:S:R149 8.885429
176S:S:P152 4.628549
177S:S:E154 7.072528
178S:S:N155 4.8025427
179S:S:F157 6.184507
180S:S:P160 6.7975429
181S:S:R161 5.958528
182S:S:F168 7.5726
183S:S:W170 9.10833629
184S:S:T175 6.205428
185S:S:Q178 11.164529
186S:S:R182 8.70333627
187S:S:Y183 7.304527
188S:S:P186 3.67333628
189S:S:H187 10.5717627
190S:S:M190 6.1725409
191S:S:F207 7.708528
192S:S:R224 7.824119
193S:S:L227 6.145408
194S:S:N229 4.71833627
195S:S:N231 8.0325427
196S:S:H233 7.7422
197S:S:F234 9.06167626
198S:S:R236 5.61406
199S:S:F239 5.66754128
200S:S:L245 5.97254114
201S:S:Q253 5.992528
202S:S:W254 7.5725409
203S:S:W264 6.791437129
204S:S:W265 7.6345127
205S:S:D270 5.66254351
206S:S:C273 6.7354359
207S:S:L282 6.84754126
208S:S:L287 5.585405
209S:S:V288 4.495427
210S:S:L291 6.625406
211S:S:L293 5.23445
212S:S:Y309 7.32143748
213S:S:Y313 8.83857747
214S:S:H325 9.27667647
215S:S:Y327 6.802547
216S:S:T328 4.92448
217S:S:Y329 9.352549
218S:S:D330 5.42649
219S:S:W333 7.16667649
220S:S:Y341 9.4054375
221S:S:F353 6.3725437
222S:S:Y355 8.62437
223S:S:W360 5.368535
224S:S:F364 8.765437
225S:S:F373 5.19667649
226S:S:V376 5.51333648
227S:S:R387 6.626549
228S:S:Q395 6.474529
229S:S:F396 7.8445126
230S:S:Q397 7.86426
231S:S:K403 4.8365205
232S:S:I404 3.864526
233S:S:E406 7.9525206
234S:S:Y407 4.59333627
235S:S:L418 5.50254203
236S:S:V422 5.07425
237S:S:W424 11.55529
238S:S:P429 9.0275427
239S:S:Q442 7.8185165
240S:S:I447 5.4054387
241S:S:N469 8.2654189
242S:S:Y477 8.61754186
243S:S:M480 7.6454408
244S:S:P483 5.314189
245S:S:L488 4.224416
246S:S:Y497 4.438758399
247S:S:W524 5.9325408
248S:S:M527 4.30254427
249S:S:L532 3.654417
250S:S:F534 8.705409
251S:S:M537 3.61509
252S:S:K540 8.568509
253S:S:H545 6.564199
254S:S:F548 10.68754198
255S:S:V567 2.9185419
256S:S:F587 8.93254177
257S:S:R589 7.698508
258S:S:P596 2.15404
259S:S:E612 3.91754169
260S:S:Q615 7.065176
261S:S:E617 7.21754174
262S:S:Y629 9.2254438
263S:S:L634 4.0825409
264S:S:D654 7.29254409
265S:S:K683 4.6545168
266S:S:F687 7.6185168
267S:S:T698 5.495398
268S:S:L702 3.655409
269S:S:F706 11.8125409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:S116 98.18877.54YesNo008
2R:R:S116 R:R:S140 98.19444.89NoYes088
3R:R:L143 R:R:S140 98.23983YesYes088
4R:R:L143 R:R:L152 60.78244.15YesYes387
5R:R:L152 R:R:V133 26.7732.98YesYes379
6R:R:L111 R:R:V133 14.98992.98YesYes369
7R:R:L102 R:R:L111 13.89046.92YesYes376
8R:R:L102 R:R:W129 12.88889.11YesYes376
9R:R:W129 S:S:F94 23.12148.02YesYes368
10R:R:V122 R:R:V133 13.03493.21NoYes389
11R:R:M98 R:R:V122 12.95669.13NoNo378
12R:R:M98 R:R:W129 12.88263.49NoYes376
13S:S:F93 S:S:F94 17.32944.29YesYes388
14R:R:L143 R:R:T120 37.25622.95YesNo086
15R:R:F149 R:R:T120 37.2385.19YesNo086
16R:R:F149 R:R:L152 41.32937.31YesYes387
17R:R:F149 R:R:R148 79.456418.17YesNo385
18R:R:E124 R:R:R148 79.39484.65NoNo075
19R:R:E124 S:S:P117 79.22124.72NoNo077
20L:L:?1 R:R:W264 52.07913.89YesYes104
21L:L:?1 R:R:Y236 49.23036.73YesYes107
22R:R:Q183 R:R:Y236 48.94345.64YesYes187
23R:R:F235 R:R:Q183 49.99444.68YesYes188
24R:R:F235 R:R:F261 48.23166.43YesYes186
25R:R:F261 R:R:W259 98.71587.02YesYes069
26R:R:W264 R:R:Y265 53.82764.82YesYes146
27R:R:W269 R:R:Y265 53.529213.5YesYes196
28R:R:F261 R:R:W269 49.56078.02YesYes169
29R:R:L252 R:R:W259 1003.42NoYes079
30R:R:H257 R:R:L252 99.77296.43NoNo087
31R:R:H257 R:R:R229 99.54752.26NoNo089
32R:R:R229 R:R:T455 99.32195.17NoNo096
33R:R:K629 R:R:T455 99.09611.5YesNo046
34R:R:K629 R:R:V457 97.05481.52YesNo043
35R:R:R631 R:R:V457 96.94092.62NoNo043
36R:R:H459 R:R:R631 96.826939.49NoNo014
37R:R:E633 R:R:H459 96.712934.46NoNo041
38R:R:E633 R:R:L461 96.48486.63NoNo042
39R:R:E635 R:R:L461 96.37065.3YesNo072
40R:R:E635 R:R:Y536 91.470210.1YesYes874
41R:R:P537 R:R:Y536 91.184.17NoYes034
42R:R:P537 R:R:Q541 90.94693.16NoNo036
43R:R:Q541 R:R:Q604 88.72195.12NoNo066
44R:R:Q604 R:R:W545 88.60435.48NoNo065
45R:R:L600 R:R:W545 88.13336.83NoNo075
46R:R:L600 R:R:S548 88.01549.01NoNo077
47R:R:K653 R:R:S548 87.89754.59YesNo097
48R:R:F551 R:R:K653 83.49768.69YesYes099
49R:R:F551 R:R:Y555 82.57887.22YesYes598
50R:R:I685 R:R:Y555 14.18717.25YesYes088
51R:R:I685 R:R:M558 13.62097.29YesYes088
52R:R:M558 R:R:V681 16.02947.61YesYes588
53R:R:F729 R:R:I728 22.50535.02YesNo598
54R:R:V688 R:R:Y555 26.8486.31YesYes588
55R:R:M558 R:R:V688 13.6463.04YesYes588
56R:R:M558 R:R:S684 10.94996.13YesYes588
57R:R:I728 R:R:S684 15.57353.1NoYes588
58R:R:F559 R:R:Y555 44.70755.16YesYes088
59R:R:F559 R:R:F659 42.77448.57YesYes086
60R:R:F659 S:S:F639 41.195710.72YesNo069
61S:S:F639 S:S:V635 41.05912.62NoNo095
62S:S:L632 S:S:V635 40.92231.49NoNo075
63R:R:V658 S:S:L632 40.64875.96NoNo057
64R:R:V658 S:S:F636 40.51182.62NoNo058
65R:R:F662 S:S:F636 40.374911.79YesNo098
66R:R:F662 S:S:W542 32.78233.01YesNo099
67S:S:F36 S:S:F93 17.8414.29YesYes378
68S:S:F36 S:S:G35 14.95443.01YesNo076
69S:S:G35 S:S:M77 14.88033.49NoYes067
70S:S:D116 S:S:P117 79.13853.22YesNo087
71S:S:D116 S:S:M138 76.98684.16YesYes288
72S:S:M138 S:S:T112 29.4833.01YesYes289
73S:S:H136 S:S:M138 46.893810.51YesYes288
74S:S:R182 S:S:T112 29.59773.88YesYes279
75S:S:H136 S:S:R182 29.283916.93YesYes287
76S:S:E154 S:S:R182 17.823411.63YesYes287
77S:S:E154 S:S:F157 25.7665.83YesYes087
78S:S:H136 S:S:P137 17.53449.15YesYes288
79S:S:R182 S:S:Y183 43.609510.29YesYes277
80S:S:N229 S:S:Y183 14.66383.49YesYes277
81S:S:F157 S:S:I391 16.64025.02YesNo077
82S:S:I391 S:S:P160 10.344610.16NoYes279
83S:S:N229 S:S:R161 16.15437.23YesYes278
84S:S:I393 S:S:V288 11.05333.07NoYes287
85S:S:L255 S:S:R161 10.32074.86NoYes068
86S:S:I393 S:S:I404 15.81712.94NoYes286
87S:S:Q178 S:S:Y183 30.102911.27YesYes297
88S:S:F207 S:S:Q178 28.94895.86YesYes289
89S:S:F207 S:S:F230 24.3554.29YesNo289
90S:S:F230 S:S:I256 23.88936.28NoNo297
91S:S:I256 S:S:L287 23.66035.71NoYes075
92S:S:L287 S:S:W264 13.62463.42YesYes059
93S:S:I404 S:S:Q397 10.99544.12YesYes266
94S:S:F538 S:S:W542 32.08844.01NoNo099
95S:S:F534 S:S:F538 31.81096.43YesNo099
96S:S:F530 S:S:F534 13.778417.15NoYes099
97S:S:F530 S:S:K630 12.757117.37NoNo099
98S:S:I626 S:S:K630 12.61922.91NoNo079
99S:S:I577 S:S:I626 12.47292.94NoNo077
100S:S:F622 S:S:I577 12.18027.54NoNo087
101S:S:F622 S:S:W581 11.740732.07NoNo089
102S:S:Q615 S:S:W581 11.14827.67YesNo1769
103S:S:F534 S:S:V662 17.96853.93YesNo099
104S:S:M537 S:S:V662 17.1063.04YesNo099
105S:S:M537 S:S:S661 11.29666.13YesNo099
106S:S:S661 S:S:T701 10.86414.8NoNo099
107S:S:T698 S:S:T701 10.71713.14YesNo089
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:W51 20.43 1 Yes Yes 0 5 0 1
L:L:?1 R:R:S116 7.54 1 Yes No 0 8 0 1
L:L:?1 R:R:S139 7.54 1 Yes No 0 7 0 1
L:L:?1 R:R:H156 11.07 1 Yes Yes 0 6 0 1
L:L:?1 R:R:Y236 6.73 1 Yes Yes 0 7 0 1
L:L:?1 R:R:W264 13.89 1 Yes Yes 0 4 0 1
L:L:?1 R:R:E343 7.61 1 Yes Yes 0 5 0 1
R:R:G53 R:R:W51 11.26 0 No Yes 4 5 2 1
R:R:W51 R:R:Y136 2.89 1 Yes Yes 5 7 1 2
R:R:G340 R:R:W51 4.22 0 No Yes 3 5 2 1
R:R:E343 R:R:W51 14.17 1 Yes Yes 5 5 1 1
R:R:S116 R:R:S140 4.89 0 No Yes 8 8 1 2
R:R:G137 R:R:H156 4.77 0 No Yes 7 6 2 1
R:R:H156 R:R:S139 6.97 1 Yes No 6 7 1 1
R:R:H156 R:R:P157 6.1 1 Yes Yes 6 7 1 2
R:R:E343 R:R:H156 6.15 1 Yes Yes 5 6 1 1
R:R:H156 R:R:L346 6.43 1 Yes Yes 6 6 1 2
R:R:L346 R:R:P157 3.28 1 Yes Yes 6 7 2 2
R:R:H162 R:R:W264 3.17 1 Yes Yes 5 4 2 1
R:R:F188 R:R:Q183 5.86 1 Yes Yes 6 8 2 2
R:R:Q183 R:R:Y236 5.64 1 Yes Yes 8 7 2 1
R:R:F188 R:R:Y236 16.5 1 Yes Yes 6 7 2 1
R:R:W264 R:R:Y236 3.86 1 Yes Yes 4 7 1 1
R:R:I262 R:R:W264 12.92 1 No Yes 4 4 2 1
R:R:I262 R:R:Y265 8.46 1 No Yes 4 6 2 2
R:R:W264 R:R:Y265 4.82 1 Yes Yes 4 6 1 2
R:R:E343 R:R:M300 5.41 1 Yes No 5 5 1 2
R:R:L346 R:R:M300 5.65 1 Yes No 6 5 2 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription

PDB Summary
PDB 9JQX
Class C
SubFamily Aminoacid
Type GABAB
SubType GABAB1; GABAB2
Species Drosophila melanogaster
Ligand CGP54626
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.61
Date 2025-10-01
D.O.I. To be published
Net Summary
Imin 2.87
Number of Linked Nodes 1298
Number of Links 1612
Number of Hubs 269
Number of Links mediated by Hubs 946
Number of Communities 43
Number of Nodes involved in Communities 405
Number of Links involved in Communities 588
Path Summary
Number Of Nodes in MetaPath 108
Number Of Links MetaPath 107
Number of Shortest Paths 5491519
Length Of Smallest Path 3
Average Path Length 44.1403
Length of Longest Path 94
Minimum Path Strength 1.22
Average Path Strength 7.00059
Maximum Path Strength 36.975
Minimum Path Correlation 0.7
Average Path Correlation 0.998122
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2
Average % Of Corr. Nodes 48.6693
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.966
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .
Code2BV
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
Code2BV
Name(R)-(cyclohexylmethyl)[(2S)-3-{[(1S)-1-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropyl]phosphinic acid
SynonymsCGP 54626
Identifier
FormulaC18 H28 Cl2 N O3 P
Molecular Weight408.3
SMILES
PubChem197584
Formal Charge0
Total Atoms53
Total Chiral Atoms2
Total Bonds54
Total Aromatic Bonds6

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ9BML7
Sequence
>9JQX_Chain_R
ELHIGGIFP IAGKGGWQG GQACMPATR LALDDVNKQ PNLLPGFKL 
ILHSNDSEC EPGLGASVM YNLLYNKPQ KLMLLAGCS TVCTTVAEA 
AKMWNLIVL CYGASSPAL SDRKRFPTL FRTHPSATV HNPTRIKLM 
KKFGWSRVA ILQQAEEVF ISTVEDLEN RCMEAGVEI VTRQSFLSD 
PTDAVRNLR RQDARIIVG LFYVVAARR VLCEMYKQQ LYGRAHVWF 
FIGWYEDNW YEVNLKAEG ITCTVEQMR IAAEGHLTT EALMWNQNN 
QTTISGMTA EEFRHRLNQ ALIEEGYDI NHDRYPEGY QEAPLAYDA 
VWSVALAFN KTMERLTTG KKSLRDFTY TDKEIADEI YAAMNSTQF 
LGVSGVVAF SSQGDRIAL TQIEQMIDG KYEKLGYYD TQLDNLSWL 
NTEQWIGGK VPQDRTIVT HVLRTVSLP LFVCMCTIS SCGIFVAFA 
LIIFNIWNK HRRVIQSSH PVCNTIMLF GVIICLISV ILLGIDGRF 
VSPEEYPKI CQARAWLLS TGFTLAYGA MFSKVWRVH RFTTKAEPW 
KLYTMVSGL LSIDLVILL SWQIFDPLQ RYLETFPLE DPVSTTDDI 
KIRPELEHC ESQRNSMWL GLVYGFKGL ILVFGLFLA YETRSIKVK 
QINDSRYVG MSIYNVVVL CLITAPVGM VIASQQDAS FAFVALAVI 
FCCFLSMLL IFVPKVIEV IR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ9BML6
Sequence
>9JQX_Chain_S
SDVYIAGFF PYGDGVENS YTGRGVMPS VKLALGHVN EHGKILANY 
RLHMWWNDT QCNAAVGVK SFFDMMHSG PNKVMLFGA ACTHVTDPI 
AKASKHWHL TQLSYADTH PMFTKDAFP NFFRVVPSE NAFNAPRLA 
LLKEFNWTR VGTVYQNEP RYSLPHNHM VADLDAMEV EVVETQSFV 
NDVAESLKK LREKDVRII LGNFNEHFA RKAFCEAYK LDMYGRAYQ 
WLIMATYST DWWNVTQDS ECSVEEIAT ALEGAILVD LLPLSTSGD 
ITVAGITAD EYLVEYDRL RGTEYSRFH GYTYDGIWA AALAIQYVA 
EKREDLLTH FDYRVKDWE SVFLEALRN TSFEGVTGP VRFYNNERK 
ANILINQFQ LGQMEKIGE YHSQKSHLD LSLGKPVKW VGKTPPKDR 
TLIYIEHSQ VNPTIYIVS ASASVIGVI IATVFLAFN IKYRNQRYI 
KMSSPHLNN LIIVGCMIT YLSIIFLGL DTTLSSVAA FPYICTARA 
WILMAGFSL SFGAMFSKT WRVHSIFTQ LFMVVGVLL AIDIAIITT 
WQIADPFYR ETKQLEPLH PENEYCQSE HMTIFVSII YAYKGLLLV 
FGAFLAWET RHVSIPALN DSKHIGFSV YNVFITCLA GAAISLVLS 
DRKDLVFVL LSFFIIFCT TATLCLVFV PKLV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6UO8CAminoacidGABABGABAB1, GABAB2Homo sapiensSKF97541GS39783-3.632020-06-10doi.org/10.1038/s41586-020-2408-4
6UO9CAminoacidGABABGABAB1, GABAB2Homo sapiensSKF97541--4.82020-06-10doi.org/10.1038/s41586-020-2408-4
6UOACAminoacidGABABGABAB1, GABAB2Homo sapiens---6.32020-06-10doi.org/10.1038/s41586-020-2408-4
6VJMCAminoacidGABABGABAB1, GABAB2Homo sapiens---3.972020-06-10doi.org/10.1038/s41586-020-2408-4
6W2YCAminoacidGABABGABAB1; GABAB1Homo sapiensPubChem 5311042--3.22020-07-01doi.org/10.1038/s41586-020-2469-4
6W2XCAminoacidGABABGABAB1, GABAB2Homo sapiensPubChem 5311042--3.62020-07-01doi.org/10.1038/s41586-020-2469-4
6WIVCAminoacidGABABGABAB1, GABAB2Homo sapiens-PubChem 52923113; PubChem 52924645-3.32020-07-01doi.org/10.1038/s41586-020-2452-0
7C7QCAminoacidGABABGABAB1, GABAB2Homo sapiensBaclofenBHFF-32020-07-01doi.org/10.1038/s41422-020-0350-5
7C7SCAminoacidGABABGABAB1, GABAB2Homo sapiensCGP54626--2.92020-07-01doi.org/10.1038/s41422-020-0350-5
7CA3CAminoacidGABABGABAB1, GABAB2Homo sapiens-rac-BHFF-4.52020-11-11doi.org/10.1016/j.jmb.2020.09.023
7CA5CAminoacidGABABGABAB1, GABAB2Homo sapiens---7.62020-11-11doi.org/10.1016/j.jmb.2020.09.023
7CUMCAminoacidGABABGABAB1, GABAB2Homo sapiensCGP54626--3.522020-11-11doi.org/10.1016/j.jmb.2020.09.023
7EB2CAminoacidGABABGABAB2; GABAB1Homo sapiensBaclofenrac-BHFFGi1/β1/γ23.52021-05-05doi.org/10.1038/s41586-021-03507-1
7EB2 (No Gprot) CAminoacidGABABGABAB2; GABAB1Homo sapiensBaclofenrac-BHFF3.52021-05-05doi.org/10.1038/s41586-021-03507-1
9JR0CAminoacidGABABGABAB2; GABAB1Drosophila melanogasterGABA-Gi1/β1/γ23.062025-10-22To be published
9JR0 (No Gprot) CAminoacidGABABGABAB2; GABAB1Drosophila melanogasterGABA-3.062025-10-22To be published




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Download 9JQX.zip



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