Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L44 5.75429
2A:A:L45 6.8488
3A:A:E209 8.13429
4A:A:F219 4.94408
5A:A:F222 10.015427
6A:A:F238 8.044529
7A:A:I244 3.2975428
8A:A:I245 5.9075487
9A:A:L282 5.58754209
10A:A:V287 4.51406
11A:A:I288 5.03589
12A:A:L289 3.96409
13A:A:F290 4.765489
14A:A:Q294 6.335406
15A:A:F312 2.43408
16A:A:Y318 9.695406
17A:A:P321 4.4075405
18A:A:E330 6.6025403
19A:A:D331 5.254234
20A:A:V334 4.1585234
21A:A:F340 13.364247
22A:A:F345 4.282508
23A:A:R356 5.28502
24A:A:H357 5.0025407
25A:A:C359 4.1275405
26A:A:F376 6.5675408
27A:A:D378 7.795487
28A:A:D381 7.694148
29A:A:R385 9.4925145
30A:A:L388 4.95408
31B:B:I18 4.8875407
32B:B:R19 7.82254264
33B:B:R22 4.526506
34B:B:Q32 4.3054281
35B:B:I37 2.6775402
36B:B:I43 3.064293
37B:B:M45 3.58404
38B:B:R48 5.7775477
39B:B:L51 6.145449
40B:B:H54 6.774549
41B:B:L55 6.9275406
42B:B:K57 13.3625429
43B:B:Y59 6.534528
44B:B:W63 6.718547
45B:B:S72 4.6075449
46B:B:W82 6.79667649
47B:B:Y85 7.72667674
48B:B:K89 5.925449
49B:B:I93 4.6625407
50B:B:L95 4.8745158
51B:B:W99 7.662529
52B:B:Y105 5.242506
53B:B:C114 3.81754158
54B:B:Y124 5.5225406
55B:B:K127 5.9125404
56B:B:H142 7.3025439
57B:B:Y145 6.7975438
58B:B:F151 3.282509
59B:B:T159 5.4825439
60B:B:S161 6.6625439
61B:B:D163 8.4075439
62B:B:W169 8.065438
63B:B:I171 3.3845306
64B:B:F180 6.958597
65B:B:H183 6.286599
66B:B:V187 4.685499
67B:B:V200 5.62456
68B:B:D205 6.4225409
69B:B:W211 6.812598
70B:B:H225 9.606559
71B:B:F234 6.775455
72B:B:F235 6.873336316
73B:B:F241 6.454556
74B:B:S245 6.5525459
75B:B:T249 6.042556
76B:B:F253 5.388556
77B:B:I269 6.2554114
78B:B:F278 5.12254317
79B:B:L284 3.3125405
80B:B:Y289 4.6385117
81B:B:V296 5.254295
82B:B:K301 6.0025405
83B:B:R304 8.9754115
84B:B:L308 4.0845297
85B:B:H311 9.3554329
86B:B:R314 7.308528
87B:B:T321 6.472547
88B:B:W332 12.702529
89B:B:D333 9.784329
90B:B:L336 3.538547
91B:B:N340 4.475479
92G:G:N59 4.125479
93G:G:F61 5.17778
94R:R:V61 1.866509
95R:R:T68 2.935406
96R:R:F71 8.4475409
97R:R:L78 3.545408
98R:R:L82 6.665409
99R:R:D86 7.325409
100R:R:F101 10.3525405
101R:R:I130 4.325408
102R:R:V132 4.35416
103R:R:Y135 6.712518
104R:R:Y144 8.445108
105R:R:L157 4.434337
106R:R:W161 4.4185339
107R:R:L170 5.264124
108R:R:P171 5.19754124
109R:R:S191 2.3575405
110R:R:H194 8.19254126
111R:R:F202 4.622567
112R:R:F203 5.12565
113R:R:I208 4.575416
114R:R:Q211 7.985403
115R:R:L212 5.69405
116R:R:Q215 11.115416
117R:R:F256 4.356568
118R:R:W260 4.99714768
119R:R:L261 2.7475464
120R:R:L268 3.6775465
121R:R:N293 6.73409
122R:R:P294 2.465409
123S:S:N58 6.63754179
124S:S:T68 7.0975406
125S:S:P74 3.5925416
126S:S:D86 6.73754179
127S:S:H96 4.735405
128S:S:F101 9.188505
129S:S:S105 3.205406
130S:S:F120 6.36254355
131S:S:L128 3.488517
132S:S:V132 5.9275416
133S:S:Y135 5.918518
134S:S:Y144 7.02167618
135S:S:R152 5.33516
136S:S:Y154 3.675402
137S:S:M156 4.89416
138S:S:F202 4.815417
139S:S:F206 3.1925416
140S:S:M209 4.1425418
141S:S:Q211 11.9975413
142S:S:Y213 6.22519
143S:S:Q215 10.13416
144S:S:F256 3.7525418
145S:S:W260 8.5545358
146W:W:?1 8.4221010
147X:X:?1 9.689091110
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D83 B:B:Y85 18.14383.45NoYes784
2B:B:D83 B:B:L69 17.98212.71NoNo085
3B:B:L69 B:B:Y105 17.83037.03NoYes056
4B:B:L51 B:B:W82 54.548410.25YesYes499
5B:B:L51 B:B:T87 34.36135.9YesNo095
6B:B:R49 B:B:T87 34.22843.88NoNo075
7B:B:R49 B:B:Y85 14.06555.14NoYes774
8B:B:D76 B:B:S74 61.07137.36NoNo099
9B:B:H54 B:B:S74 60.86136.97YesNo099
10B:B:H54 B:B:W82 56.850310.58YesYes499
11B:B:D76 B:B:L55 61.6069.5NoYes096
12A:A:K34 B:B:L55 99.8765.64NoYes046
13A:A:K34 A:A:R38 99.95894.95NoNo044
14A:A:Y37 B:B:L55 38.89067.03NoYes046
15A:A:R42 A:A:Y37 38.745811.32NoNo094
16B:B:S84 G:G:F61 28.70823.96NoYes058
17A:A:D240 B:B:K57 38.6296.91NoYes069
18A:A:D240 A:A:R42 38.68115.96NoNo069
19A:A:R38 R:R:Y145 1003.09NoNo043
20A:A:C237 A:A:F238 44.6275.59NoYes289
21A:A:C237 B:B:Y59 44.13325.38NoYes288
22B:B:W332 B:B:Y59 13.49277.72YesYes298
23A:A:D378 A:A:I382 14.53544.2YesNo876
24A:A:I382 A:A:S286 18.47126.19NoNo068
25A:A:H357 A:A:S286 18.66892.79YesNo078
26A:A:H357 A:A:W277 20.829212.7YesNo076
27A:A:V287 A:A:W277 20.62543.68YesNo066
28A:A:I244 A:A:V287 33.73853.07YesYes086
29A:A:I244 A:A:L44 33.72152.85YesYes289
30A:A:F238 A:A:L44 34.495910.96YesYes299
31A:A:H387 R:R:Y145 25.67817.62NoNo1083
32A:A:H387 R:R:S137 25.625911.16NoNo1089
33R:R:Y144 R:R:Y145 74.362719.86YesNo1083
34R:R:S137 R:R:Y144 25.85363.82NoYes1098
35R:R:L136 W:W:?1 46.84639.76NoYes050
36R:R:L136 R:R:R152 46.8649.72NoNo056
37R:R:R152 R:R:T149 46.94863.88NoNo068
38R:R:T149 R:R:Y144 46.30339.99NoYes1088
39A:A:Y391 R:R:S137 51.30213.82NoNo049
40A:A:Y391 R:R:R134 50.95337.2NoNo049
41B:B:N340 G:G:F61 43.76663.62YesYes798
42B:B:M45 B:B:N340 43.65022.8YesYes049
43B:B:L308 B:B:M45 40.63854.24YesYes074
44B:B:L308 B:B:V296 42.09434.47YesYes2975
45B:B:L284 B:B:V296 41.8475.96YesYes055
46B:B:D298 B:B:L284 40.94082.71NoYes095
47B:B:D298 B:B:R283 37.244813.1NoNo099
48B:B:L300 B:B:R283 34.978114.58NoNo069
49B:B:L300 B:B:T34 34.314111.79NoNo065
50B:B:L30 B:B:T34 33.64935.9NoNo055
51B:B:L30 B:B:M262 31.31544.24NoNo054
52B:B:M262 B:B:Y264 30.64665.99NoNo045
53B:B:L285 B:B:Y264 22.2135.86NoNo065
54B:B:F278 B:B:L285 21.87284.87YesNo076
55B:B:F235 B:B:F278 19.80218.57YesYes3167
56B:B:F235 B:B:N237 18.100813.29YesNo065
57B:B:N237 B:B:N239 17.7796.81NoNo052
58B:B:N239 B:B:R256 17.43596.03NoNo029
59B:B:D254 B:B:R256 16.40513.57NoNo099
60B:B:D254 B:B:L261 15.71692.71NoNo095
61B:B:A257 B:B:L261 13.99243.15NoNo075
62B:B:A257 B:B:Q259 13.64693.03NoNo076
63B:B:Q259 B:B:R22 12.95513.5NoYes066
64B:B:D258 B:B:R22 10.179315.48NoYes076
65B:B:I338 B:B:S84 20.22084.64NoNo055
66B:B:H62 B:B:Y105 12.17554.36NoYes066
67B:B:H62 B:B:R150 11.995213.54NoNo066
68B:B:L192 B:B:R150 11.81473.64NoNo056
69R:R:M75 R:R:R134 50.79067.44NoNo089
70R:R:I130 R:R:M75 50.7252.92YesNo088
71R:R:I130 R:R:L78 14.52114.28YesYes088
72R:R:L157 R:R:L78 13.14822.77YesYes078
73R:R:L157 R:R:W161 12.42214.56YesYes3379
74R:R:A122 R:R:W161 15.68216.48NoYes079
75R:R:A122 R:R:A164 15.45881.79NoNo078
76R:R:A164 R:R:T121 15.23533.36NoNo086
77R:R:L167 R:R:T121 15.01167.37NoNo046
78R:R:H194 R:R:L167 14.55653.86YesNo1264
79R:R:H194 R:R:P171 12.257612.2YesYes1264
80R:R:L190 R:R:P171 11.17473.28NoYes034
81R:R:I130 R:R:L82 20.24332.85YesYes089
82R:R:L82 R:R:N293 21.624413.73YesYes099
83R:R:I130 R:R:Y297 17.47767.25YesNo089
84R:R:N293 R:R:Y297 17.09155.81YesNo099
85R:R:L127 R:R:N293 38.5334.12NoYes089
86R:R:F256 R:R:L127 33.65444.87YesNo688
87R:R:L212 R:R:T131 22.29092.95YesNo058
88R:R:M209 R:R:T131 21.74314.52NoNo088
89R:R:F256 R:R:M209 16.99927.46YesNo688
90S:S:Q211 W:W:?1 32.319418.77YesYes130
91R:R:L212 S:S:Q211 13.037813.31YesYes053
92R:R:F202 R:R:F256 41.00113.22YesYes678
93R:R:F202 R:R:F203 27.98715.36YesYes675
94R:R:A199 R:R:F203 10.7812.77NoYes045
95R:R:A199 R:R:L268 20.3734.73NoYes045
96R:R:L268 S:S:L268 29.30664.15YesNo055
97R:R:V196 S:S:L268 26.46744.47NoNo055
98R:R:K192 R:R:V196 21.5553.04NoNo025
99R:R:K192 R:R:S191 19.89821.53NoYes025
100R:R:F202 R:R:T264 11.22949.08YesNo076
101R:R:A199 R:R:T264 10.68733.36NoNo046
102R:R:F203 S:S:I200 16.875811.3YesNo654
103R:R:L268 S:S:I200 10.23952.85YesNo654
104R:R:Q211 S:S:Q211 28.18747.68YesYes033
105R:R:Q211 X:X:?1 18.855111.26YesYes030
106S:S:L128 X:X:?1 11.1925.86YesYes170
107S:S:L128 S:S:M209 11.60332.83YesYes178
108S:S:F256 S:S:M209 11.35643.73YesYes188
109S:S:F120 S:S:W260 15.789610.02YesYes3558
110S:S:F120 S:S:S290 15.07063.96YesNo059
111S:S:D86 S:S:S290 14.82595.89YesNo099
112S:S:D86 S:S:N58 12.318413.46YesYes1799
113S:S:L87 S:S:N58 12.11946.87NoYes079
114S:S:L87 S:S:S55 11.87213NoNo076
115S:S:G90 S:S:S55 11.12871.86NoNo086
116B:B:R49 G:G:F61 20.09596.41NoYes778
117B:B:I338 B:B:L51 20.28744.28NoYes059
118B:B:K57 B:B:Y59 35.09663.58YesYes298
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:Q211 R:R:Q215 7.68 0 Yes Yes 3 6 1 2
R:R:Q211 S:S:Q211 7.68 0 Yes Yes 3 3 1 2
R:R:Q211 S:S:L212 5.32 0 Yes No 3 5 1 2
R:R:Q211 X:X:?1 11.26 0 Yes Yes 3 0 1 0
R:R:Q215 S:S:Y135 5.64 1 Yes Yes 6 8 2 2
R:R:R218 S:S:R152 4.26 1 No Yes 4 6 1 1
R:R:R218 X:X:?1 15.42 1 No Yes 4 0 1 0
S:S:L128 S:S:V132 2.98 1 Yes Yes 7 6 1 1
S:S:I208 S:S:L128 4.28 1 No Yes 6 7 1 1
S:S:L128 S:S:M209 2.83 1 Yes Yes 7 8 1 2
S:S:L128 X:X:?1 5.86 1 Yes Yes 7 0 1 0
S:S:A129 S:S:M156 4.83 0 No Yes 7 6 2 1
S:S:M156 S:S:V132 3.04 1 Yes Yes 6 6 1 1
S:S:L212 S:S:V132 2.98 0 No Yes 5 6 2 1
S:S:V132 X:X:?1 14.71 1 Yes Yes 6 0 1 0
S:S:L136 S:S:Y135 3.52 1 No Yes 5 8 1 2
S:S:L136 S:S:R152 12.15 1 No Yes 5 6 1 1
S:S:L136 X:X:?1 13.66 1 No Yes 5 0 1 0
S:S:R152 S:S:Y144 3.09 1 Yes Yes 6 8 1 2
S:S:M156 S:S:R152 3.72 1 Yes Yes 6 6 1 1
S:S:R152 X:X:?1 3.43 1 Yes Yes 6 0 1 0
S:S:L159 S:S:V155 2.98 0 No No 4 4 2 1
S:S:V155 X:X:?1 4.2 0 No Yes 4 0 1 0
S:S:M156 X:X:?1 7.97 1 Yes Yes 6 0 1 0
S:S:I208 X:X:?1 14.09 1 No Yes 6 0 1 0
R:R:A214 X:X:?1 2.22 0 No Yes 2 0 1 0
R:R:G207 S:S:I208 1.76 0 No No 4 6 2 1
S:S:L128 S:S:V205 1.49 1 Yes No 7 7 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
83.33Single9M88AF643949M88-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
83.33Single9M8PAF643949M8P-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
76.92Single9M88AF643949M88-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
75.00Single9M8PAF643949M8P-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
58.33Single9M8VAF643949M8V-GPR3 ; GPR3-AF64394-chim(NtGi1-Gs)/β1/γ2
38.46Single7CKZMevidalen7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
30.77Single8XXUA1D5Q8XXU-DP2-A1D5Q-Gi1/β1/γ2
30.77Single9JCPLPC9JCP-GPR4-LPC-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single9CM7AZ-17299CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
29.41Single9IYBA1D5Q9IYB-DP2-PGD2-A1D5Q-Gi1/β1/γ2
28.57Single7LJDMevidalen7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
28.57Single7X2FMevidalen7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
28.57Single9CM3PubChem 1186158109CM3-FFA2-TUG-1375-PubChem 118615810-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57Single9JCOLPC9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
27.78Single8XXVA1D5Q8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
26.67Single7LJCMevidalen7LJC-D1-SKF81297-Mevidalen-Gs/β1/γ2
25.00Single6N48PubChem 1384542566N48-β2-BI167107-PubChem 138454256
23.81Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
23.08Single9NS9PubChem 1186158109NS9-FFA2-TUG-1375-PubChem 118615810-Gi1/β1/γ2
22.22Single8YYXLeukotriene E48YYX-Oxoglutarate-Leukotriene E4-chim(Gi1-CtGq)/β1/γ2
21.74Single5KW2PubChem 1330539535KW2-FFA1-PubChem 133053953
21.43Single6OBAGTPL110746OBA-β2-Alprenolol-GTPL11074
18.75Single8Y72BMS-9861228Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
18.75Single9JCOLPC9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
17.65Single5O9HNDT95137275O9H-C5a1-NDT9513727
16.67Single6C1RAvacopan; Na6C1R-C5a1-PMX53-Avacopan; Na
15.38Single9JCQLPC9JCQ-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
12.50Single8K9LBMS-9861228K9L-μ-DAMGO-BMS-986122-Gi3/β1/γ1
12.50Single9JCPLPC9JCP-GPR4-LPC-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9K1CDoconexent9K1C-FFA1-Doconexent-Gi1/β1/γ2
11.76Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
11.76Single8G2YLPC8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/β1/γ2
11.76Single9JCQLPC9JCQ-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
11.11Single7WU3K6G7WU3-ADGRF1-K6G-Gs/β1/γ2
10.00Single7WU5K6G7WU5-ADGRF1-K6G-Gi1/β1/γ2
9.52Single7WU4K6G7WU4-ADGRF1-K6G-Gi1/β1/γ2
7.69Single6UO8GS397836UO8-GABAB1, GABAB2-SKF97541-GS39783
7.14Single5XSZGlyceryl-mono-oleate5XSZ-LPA6-Glyceryl-mono-oleate
6.67Single7EB2rac-BHFF7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
6.25Single8WG8Peptide8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/β1/γ2
5.56Single7C7QBHFF7C7Q-GABAB1, GABAB2-Baclofen-BHFF
5.56Single7EJX(1R;2R)-2-PCCA7EJX-GPR88-(1R;2R)-2-PCCA-Gi1/β1/γ2
3.45Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
3.23Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
3.23Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.23Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.23Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
3.12Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
3.03Consensuspth1_onOrthosteric Ligand6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.78Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-1-Gs/β1/γ2
2.78Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.50Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L128 R:R:V132 2.98 1 No Yes 7 6 1 1
R:R:L128 R:R:V205 7.45 1 No No 7 7 1 2
R:R:L128 W:W:?1 3.9 1 No Yes 7 0 1 0
R:R:A129 R:R:M156 3.22 0 No No 7 6 2 1
R:R:M156 R:R:V132 3.04 1 No Yes 6 6 1 1
R:R:L212 R:R:V132 2.98 0 Yes Yes 5 6 2 1
R:R:V132 W:W:?1 8.4 1 Yes Yes 6 0 1 0
R:R:L212 R:R:Y135 3.52 0 Yes Yes 5 8 2 2
R:R:Q215 R:R:Y135 15.78 1 Yes Yes 6 8 2 2
R:R:Y135 S:S:Q215 3.38 1 Yes Yes 8 6 2 1
R:R:L136 R:R:R152 9.72 0 No No 5 6 1 2
R:R:L136 W:W:?1 9.76 0 No Yes 5 0 1 0
R:R:L159 R:R:V155 2.98 0 No No 4 4 1 2
R:R:M156 W:W:?1 3.99 1 No Yes 6 0 1 0
R:R:I208 S:S:L210 4.28 1 Yes No 6 4 1 2
R:R:I208 S:S:Q211 8.23 1 Yes Yes 6 3 1 1
R:R:I208 W:W:?1 4.03 1 Yes Yes 6 0 1 0
R:R:Q211 R:R:Q215 7.68 0 Yes Yes 3 6 2 2
R:R:Q211 S:S:Q211 7.68 0 Yes Yes 3 3 2 1
R:R:L212 S:S:Q211 13.31 0 Yes Yes 5 3 2 1
R:R:Q215 S:S:Y135 5.64 1 Yes Yes 6 8 2 2
R:R:Q215 S:S:Q215 15.36 1 Yes Yes 6 6 2 1
S:S:Q215 S:S:Y135 12.4 1 Yes Yes 6 8 1 2
S:S:Q211 W:W:?1 18.77 1 Yes Yes 3 0 1 0
S:S:Q215 W:W:?1 9.38 1 Yes Yes 6 0 1 0
S:S:R218 W:W:?1 10.28 0 No Yes 4 0 1 0
R:R:L159 W:W:?1 1.95 0 No Yes 4 0 1 0
R:R:I208 S:S:G207 1.76 1 Yes No 6 4 1 2
S:S:C221 S:S:R218 1.39 0 No No 6 4 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
69.23Single9M88AF643949M88-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
66.67Single9M8PAF643949M8P-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
61.54Single9M88AF643949M88-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
61.54Single9M8PAF643949M8P-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
58.33Single9M8VAF643949M8V-GPR3 ; GPR3-AF64394-chim(NtGi1-Gs)/β1/γ2
54.55Single7CKZMevidalen7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
33.33Single9JCPLPC9JCP-GPR4-LPC-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single9CM7AZ-17299CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
30.77Single9JCOLPC9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
26.67Single5O9HNDT95137275O9H-C5a1-NDT9513727
26.67Single6N48PubChem 1384542566N48-β2-BI167107-PubChem 138454256
25.00Single6C1RAvacopan; Na6C1R-C5a1-PMX53-Avacopan; Na
23.53Single9IYBA1D5Q9IYB-DP2-PGD2-A1D5Q-Gi1/β1/γ2
23.08Single6OBAGTPL110746OBA-β2-Alprenolol-GTPL11074
22.73Single5KW2PubChem 1330539535KW2-FFA1-PubChem 133053953
22.22Single8XXVA1D5Q8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
21.43Single9CM3PubChem 1186158109CM3-FFA2-TUG-1375-PubChem 118615810-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
20.00Single8Y72BMS-9861228Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
20.00Single9JCOLPC9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
19.05Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
16.67Single9JCQLPC9JCQ-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
15.38Single9NS9PubChem 1186158109NS9-FFA2-TUG-1375-PubChem 118615810-Gi1/β1/γ2
14.29Single8XXUA1D5Q8XXU-DP2-A1D5Q-Gi1/β1/γ2
13.33Single7LJDMevidalen7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
13.33Single7X2FMevidalen7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
13.33Single8K9LBMS-9861228K9L-μ-DAMGO-BMS-986122-Gi3/β1/γ1
13.33Single9JCPLPC9JCP-GPR4-LPC-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single9K1CDoconexent9K1C-FFA1-Doconexent-Gi1/β1/γ2
12.50Single7LJCMevidalen7LJC-D1-SKF81297-Mevidalen-Gs/β1/γ2
12.50Single8G2YLPC8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/β1/γ2
12.50Single9JCQLPC9JCQ-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
11.76Single7WU3K6G7WU3-ADGRF1-K6G-Gs/β1/γ2
10.53Single7WU5K6G7WU5-ADGRF1-K6G-Gi1/β1/γ2
10.53Single8YYXLeukotriene E48YYX-Oxoglutarate-Leukotriene E4-chim(Gi1-CtGq)/β1/γ2
10.00Single7WU4K6G7WU4-ADGRF1-K6G-Gi1/β1/γ2
7.69Single5XSZGlyceryl-mono-oleate5XSZ-LPA6-Glyceryl-mono-oleate
6.67Single8WG8Peptide8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/β1/γ2
5.56Single8IYXYL-3658IYX-GPR34-YL-365
3.57Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
3.33Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
3.33Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.33Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.33Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
3.23Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
3.12Consensuspth1_onOrthosteric Ligand6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.86Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-1-Gs/β1/γ2
2.86Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.56Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2

PDB Summary
PDB 9M8V
Class A
SubFamily Orphan
Type Orphan
SubType GPR3 ; GPR3
Species Homo Sapiens
Ligand -
Other Ligand(s) AF64394
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.83
Date 2025-09-24
D.O.I. doi.org/10.1038/s41467-025-63422-1
Net Summary
Imin 2.71
Number of Linked Nodes 1050
Number of Links 1177
Number of Hubs 147
Number of Links mediated by Hubs 534
Number of Communities 35
Number of Nodes involved in Communities 212
Number of Links involved in Communities 271
Path Summary
Number Of Nodes in MetaPath 119
Number Of Links MetaPath 118
Number of Shortest Paths 1302263
Length Of Smallest Path 3
Average Path Length 34.2461
Length of Longest Path 75
Minimum Path Strength 1.18
Average Path Strength 6.27203
Maximum Path Strength 21.48
Minimum Path Correlation 0.7
Average Path Correlation 0.990416
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.63158
Average % Of Corr. Nodes 55.3432
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 39.7579
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • cellular homeostasis   • chemical homeostasis   • homeostatic process   • glucose homeostasis   • carbohydrate homeostasis   • intracellular chemical homeostasis   • intracellular glucose homeostasis   • neuromuscular process   • regulation of system process   • skeletal muscle contraction   • muscle contraction   • muscle system process   • regulation of muscle system process   • striated muscle contraction   • multicellular organismal movement   • musculoskeletal movement   • regulation of striated muscle contraction   • regulation of muscle contraction   • regulation of skeletal muscle contraction   • regulation of multicellular organismal process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • skeletal system development   • bone development   • response to pH   • cellular response to pH   • response to abiotic stimulus   • cellular response to acidic pH   • response to acidic pH   • cellular response to abiotic stimulus   • cellular response to environmental stimulus   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • positive regulation of biological process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • positive regulation of cell communication   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • positive regulation of establishment of protein localization   • localization   • establishment of localization in cell   • positive regulation of insulin secretion involved in cellular response to glucose stimulus   • positive regulation of insulin secretion   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • positive regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular response to carbohydrate stimulus   • response to glucose   • positive regulation of protein localization   • insulin secretion involved in cellular response to glucose stimulus   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • positive regulation of secretion by cell   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • positive regulation of hormone secretion   • response to monosaccharide   • response to carbohydrate   • positive regulation of secretion   • signal release   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • positive regulation of cellular process   • positive regulation of peptide secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cellular response to glucose stimulus   • regulation of protein transport   • positive regulation of protein secretion   • peptide transport   • response to hexose   • positive regulation of transport   • regulation of cellular localization   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • regulation of insulin secretion involved in cellular response to glucose stimulus   • hormone transport   • regulation of cell communication   • insulin secretion   • positive regulation of signaling   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • serotonin receptor signaling pathway   • adenylate cyclase-activating serotonin receptor signaling pathway   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • cell surface receptor signaling pathway   • bile acid signaling pathway   • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway   • renal system process   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • endomembrane system   • trans-Golgi network   • tetrapyrrole binding   • heme binding   • electron transfer activity   • transition metal ion binding   • iron ion binding   • bioactive lipid receptor activity   • sphingosine-1-phosphate receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • electron transport chain   • metabolic process   • generation of precursor metabolites and energy   • regulation of cellular component organization   • sexual reproduction   • regulation of reproductive process   • reproductive process   • meiotic cell cycle process   • cellular component organization   • meiotic nuclear division   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • cell cycle process   • regulation of meiotic cell cycle   • regulation of cell cycle process   • meiotic cell cycle   • organelle fission   • regulation of organelle organization   • regulation of meiotic nuclear division   • organelle organization   • nuclear division   • regulation of nuclear division   • periplasmic space
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code_W_
PDB ResiduesW:W:?1 W:W:?2 X:X:?1 X:X:?2
Environment DetailsOpen EMBL-EBI Page
Code_W_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9M8V_Chain_A
EKAEKIEKQ LQKDKQVYR ATHRLLLLG AGESGKSTI VKSGIFETK 
FQVDKVNFH MFDVERRKW IQCFNDVTA IIFVVASSS TNRLQEALN 
LFKSIWNNR WLRTISVIL FLNKQDLLA EKVLAEDYF PEFARYTTP 
EDATPEPGE DPRVTRAKY FIRDEFLRI STASGDGRH YCYPHFTCA 
VDTENIRRV FNDCRDIIQ RMHLRQYEL LDAVRSM


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9M8V_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9M8V_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP46089
Sequence
>9M8V_Chain_R
PLPSPKAWD VVLCISGTL VSCENALVV AIIVGTPAF RAPMFLLVG 
SLAVADLLA GLGLVLHFA AVFCIGSAE MSLVLVGVL AMAFTASIG 
SLLAITVDR YLSLYNALT YYSETTVTR TYVMLALVW GGALGLGLL 
PVLAWNCLD GLTTCGVVY PLSKNHLVV LAIAFFMVF GIMLQLYAQ 
ICRIVCRHA QQIALQRRK GIATLAVVL GAFAACWLP FTVYCLLGD 
AHSPPLYTY LTLLPATYN SMINPIIYA FRNQDVQKV LWA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtP46089
Sequence
>9M8V_Chain_S
PLPSPKAWD VVLCISGTL VSCENALVV AIIVGTPAF RAPMFLLVG 
SLAVADLLA GLGLVLHFA AVFCIGSAE MSLVLVGVL AMAFTASIG 
SLLAITVDR YLSLYNALT YYSETTVTR TYVMLALVW GGALGLGLL 
PVLAWNCLD GLTTCGVVY PLSKNHLVV LAIAFFMVF GIMLQLYAQ 
ICRIVCRHA GIATLAVVL GAFAACWLP FTVYCLLGD AHSPPLYTY 
LTLLPATYN SMINPIIYA FRNQDVQKV LWA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8H8JAOrphanOrphanGPR35Homo sapiensLodoxamideCachim(NtGi1L-G13)/β1/γ23.22023-02-08doi.org/10.1038/s41421-022-00499-8
8H8J (No Gprot) AOrphanOrphanGPR35Homo sapiensLodoxamideCa3.22023-02-08doi.org/10.1038/s41421-022-00499-8
8SAIAOrphanOrphanGPR34Homo sapiensLysophosphatidylserine (S12)-Gi1/β1/γ23.272023-10-04doi.org/10.1073/pnas.2308435120
8SAI (No Gprot) AOrphanOrphanGPR34Homo sapiensLysophosphatidylserine (S12)-3.272023-10-04doi.org/10.1073/pnas.2308435120
8K4NAOrphanOrphanGPR34Homo sapiensPubChem 168719765-Gi1/β1/γ22.832023-10-25To be published
8K4N (No Gprot) AOrphanOrphanGPR34Homo sapiensPubChem 168719765-2.832023-10-25To be published
8WRBAOrphanOrphanGPR34Homo sapiensLysophosphatidylserine (UBL)-Gi1/β1/γ22.912023-11-08doi.org/10.1371/journal.pbio.3002387
8WRB (No Gprot) AOrphanOrphanGPR34Homo sapiensLysophosphatidylserine (UBL)-2.912023-11-08doi.org/10.1371/journal.pbio.3002387
8XBEAOrphanOrphanGPR34Homo sapiensS3E-Lysophosphatidylserine-Gi1/β1/γ13.42024-05-15doi.org/10.1038/s41467-024-45046-z
8XBE (No Gprot) AOrphanOrphanGPR34Homo sapiensS3E-Lysophosphatidylserine-3.42024-05-15doi.org/10.1038/s41467-024-45046-z
8XBGAOrphanOrphanGPR34Homo sapiensS3E-Lysophosphatidylserine--3.432024-05-15doi.org/10.1038/s41467-024-45046-z
9M88AOrphanOrphanGPR3 ; GPR3Homo sapiensOleic monoethanolamideAF64394-3.12025-09-24doi.org/10.1038/s41467-025-63422-1
9M8PAOrphanOrphanGPR3 ; GPR3Homo sapiensOleic monoethanolamideAF64394-3.422025-09-24doi.org/10.1038/s41467-025-63422-1
9M8VAOrphanOrphanGPR3 ; GPR3Homo sapiens-AF64394chim(NtGi1-Gs)/β1/γ23.832025-09-24doi.org/10.1038/s41467-025-63422-1
9M8V (No Gprot) AOrphanOrphanGPR3 ; GPR3Homo sapiens-AF643943.832025-09-24doi.org/10.1038/s41467-025-63422-1
8XBHAOrphanOrphanGPR34Homo sapiensPubChem 162656636-Gi1/β1/γ22.832023-12-27doi.org/10.1038/s41467-024-45046-z
8XBH (No Gprot) AOrphanOrphanGPR34Homo sapiensPubChem 162656636-2.832023-12-27doi.org/10.1038/s41467-024-45046-z
8XBIAOrphanOrphanGPR34Homo sapiensPubChem 162656636--3.062023-12-27doi.org/10.1038/s41467-024-45046-z
8WW2AOrphanOrphanGPR3Homo sapiens--chim(NtGi1-Gs)/β1/γ22.792024-02-14doi.org/10.1038/s41422-024-00932-5
8WW2 (No Gprot) AOrphanOrphanGPR3Homo sapiens--2.792024-02-14doi.org/10.1038/s41422-024-00932-5
8U8FAOrphanOrphanGPR3Homo sapiensPalmitic Acid-Gs/β1/γ23.492024-03-06doi.org/10.1021/acs.biochem.3c00647
8U8F (No Gprot) AOrphanOrphanGPR3Homo sapiensPalmitic Acid-3.492024-03-06doi.org/10.1021/acs.biochem.3c00647
8IYXAOrphanOrphanGPR34Homo sapiensYL-365--3.342024-03-20doi.org/10.1073/pnas.2308435120
8X2KAOrphanOrphanGPR3Homo sapiensOleic monoethanolamide-chim(NtGi1-Gs)/β1/γ23.032024-04-03doi.org/10.1038/s41422-023-00919-8
8X2K (No Gprot) AOrphanOrphanGPR3Homo sapiensOleic monoethanolamide-3.032024-04-03doi.org/10.1038/s41422-023-00919-8
8XOFAOrphanOrphanGPR30Homo sapiensLys05-chim(NtGi1-Gs-CtGq)/β1/γ22.62024-04-10doi.org/10.1038/s41422-024-00963-y
8XOF (No Gprot) AOrphanOrphanGPR30Homo sapiensLys05-2.62024-04-10doi.org/10.1038/s41422-024-00963-y
8XOGAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92024-04-10doi.org/10.1038/s41422-024-00963-y
8XOG (No Gprot) AOrphanOrphanGPR30Homo sapiens--2.92024-04-10doi.org/10.1038/s41422-024-00963-y
8XOHAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.22024-04-10doi.org/10.1038/s41422-024-00963-y
8XOH (No Gprot) AOrphanOrphanGPR30Homo sapiens--3.22024-04-10doi.org/10.1038/s41422-024-00963-y
8XOIAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.22024-04-10doi.org/10.1038/s41422-024-00963-y
8XOI (No Gprot) AOrphanOrphanGPR30Homo sapiens--3.22024-04-10doi.org/10.1038/s41422-024-00963-y
8XOJAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.12024-04-10doi.org/10.1038/s41422-024-00963-y
8XOJ (No Gprot) AOrphanOrphanGPR30Homo sapiens--3.12024-04-10doi.org/10.1038/s41422-024-00963-y
8IZ4AOrphanOrphanGPR34Homo sapiensLysophosphatidylserine (TJR)-Gi1/β1/γ22.942024-04-10To be published
8IZ4 (No Gprot) AOrphanOrphanGPR34Homo sapiensLysophosphatidylserine (TJR)-2.942024-04-10To be published
9LYBAOrphanOrphanGPR3Homo sapiens--Gs/β1/γ23.162025-04-09doi.org/10.1016/j.celrep.2025.115478
9LYB (No Gprot) AOrphanOrphanGPR3Homo sapiens--3.162025-04-09doi.org/10.1016/j.celrep.2025.115478
9LYCAOrphanOrphanGPR3; GPR3Homo sapiens--Gs/β1/γ23.062025-04-09doi.org/10.1016/j.celrep.2025.115478
9LYC (No Gprot) AOrphanOrphanGPR3; GPR3Homo sapiens--3.062025-04-09doi.org/10.1016/j.celrep.2025.115478
9LYDAOrphanOrphanGPR3; GPR3Homo sapiens---3.662025-04-09doi.org/10.1016/j.celrep.2025.115478




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9M8V.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.