psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L37	R:R:P38	4.93	No	No	0	4	6
2	R:R:G104	R:R:L37	3.42	No	No	0	4	4
3	R:R:F101	R:R:P38	8.67	Yes	No	0	5	6
4	R:R:P40	R:R:S39	3.56	No	No	0	4	5
5	R:R:F101	R:R:P40	18.78	Yes	No	0	5	4
6	R:R:K41	R:R:W43	2.32	No	No	0	5	6
7	R:R:W43	R:R:Y280	5.79	No	No	0	6	3
8	R:R:D44	R:R:F97	2.39	No	No	0	8	5
9	R:R:D44	R:R:F101	4.78	No	Yes	0	8	5
10	R:R:D44	R:R:Y280	9.2	No	No	0	8	3
11	R:R:C48	R:R:F97	16.76	No	No	0	3	5
12	R:R:L53	R:R:M291	2.83	No	No	0	5	6
13	R:R:S290	R:R:V54	6.46	No	No	0	9	7
14	R:R:M291	R:R:V54	3.04	No	No	0	6	7
15	R:R:G90	R:R:S55	3.71	No	No	0	8	6
16	R:R:D86	R:R:N58	13.46	Yes	No	0	9	9
17	R:R:N58	R:R:P294	3.26	No	Yes	0	9	9
18	R:R:I64	R:R:L60	4.28	No	No	0	7	8
19	R:R:F299	R:R:V61	2.62	No	Yes	0	5	9
20	R:R:I64	R:R:V304	4.61	No	No	0	7	8
21	R:R:G67	R:R:T68	1.82	No	Yes	0	6	6
22	R:R:F71	R:R:T68	6.49	Yes	Yes	0	9	6
23	R:R:F71	R:R:F76	13.93	Yes	No	0	9	9
24	R:R:D303	R:R:F71	10.75	No	Yes	0	6	9
25	R:R:F71	R:R:V304	2.62	Yes	No	0	9	8
26	R:R:A73	R:R:P74	1.87	No	No	0	7	6
27	R:R:A73	R:R:F76	4.16	No	No	0	7	9
28	R:R:P74	R:R:Y144	4.17	No	Yes	7	6	8
29	R:R:P74	R:R:T149	3.5	No	No	7	6	8
30	R:R:I130	R:R:M75	2.92	Yes	No	0	8	8
31	R:R:M75	R:R:R134	7.44	No	No	0	8	9
32	R:R:F76	R:R:N301	4.83	No	No	0	9	8
33	R:R:I130	R:R:L78	4.28	Yes	Yes	0	8	8
34	R:R:D133	R:R:L78	2.71	No	Yes	0	9	8
35	R:R:L78	R:R:T153	4.42	Yes	No	0	8	6
36	R:R:L157	R:R:L78	2.77	Yes	Yes	0	7	8
37	R:R:A83	R:R:G80	1.95	No	No	0	9	6
38	R:R:S126	R:R:S81	4.89	No	No	0	8	9
39	R:R:L157	R:R:S81	9.01	Yes	No	4	7	9
40	R:R:S81	R:R:W161	6.18	No	Yes	4	9	9
41	R:R:D86	R:R:L82	4.07	Yes	Yes	0	9	9
42	R:R:L82	R:R:S126	6.01	Yes	No	0	9	8
43	R:R:I130	R:R:L82	2.85	Yes	Yes	0	8	9
44	R:R:L82	R:R:N293	13.73	Yes	Yes	0	9	9
45	R:R:A122	R:R:A85	1.79	No	No	4	7	8
46	R:R:A85	R:R:W161	2.59	No	Yes	4	8	9
47	R:R:D86	R:R:S123	2.94	Yes	No	0	9	9
48	R:R:D86	R:R:S290	8.83	Yes	No	0	9	9
49	R:R:L88	R:R:W161	2.28	No	Yes	0	7	9
50	R:R:A89	R:R:G90	1.95	No	No	0	8	8
51	R:R:A119	R:R:A89	1.79	No	No	0	6	8
52	R:R:L116	R:R:L93	2.77	No	No	0	5	6
53	R:R:L112	R:R:L95	5.54	No	No	0	5	7
54	R:R:H96	R:R:S109	2.79	No	No	0	5	9
55	R:R:H96	R:R:L112	6.43	No	No	0	5	5
56	R:R:H96	R:R:V113	2.77	No	No	0	5	5
57	R:R:F101	R:R:V100	9.18	Yes	No	0	5	4
58	R:R:E107	R:R:S105	8.62	No	No	0	1	6
59	R:R:E107	R:R:M108	8.12	No	No	0	1	4
60	R:R:L110	R:R:V172	4.47	No	No	0	4	5
61	R:R:L110	R:R:L178	4.15	No	No	0	4	1
62	R:R:P189	R:R:V113	3.53	No	No	0	2	5
63	R:R:A117	R:R:G114	1.95	No	No	0	4	6
64	R:R:A117	R:R:G168	1.95	No	No	0	4	6
65	R:R:F120	R:R:W260	7.02	No	Yes	0	5	8
66	R:R:A164	R:R:T121	3.36	No	No	0	8	6
67	R:R:L167	R:R:T121	7.37	No	No	0	4	6
68	R:R:A122	R:R:W161	6.48	No	Yes	4	7	9
69	R:R:A122	R:R:A164	1.79	No	No	0	7	8
70	R:R:F256	R:R:I124	2.51	Yes	No	2	8	7
71	R:R:I124	R:R:W260	10.57	No	Yes	2	7	8
72	R:R:G125	R:R:V160	5.52	No	No	0	4	6
73	R:R:L127	R:R:M209	2.83	No	No	2	8	8
74	R:R:F256	R:R:L127	4.87	Yes	No	2	8	8
75	R:R:L127	R:R:N293	4.12	No	Yes	0	8	9
76	R:R:L128	R:R:V132	2.98	No	Yes	1	7	6
77	R:R:L128	R:R:V205	7.45	No	No	0	7	7
78	R:R:L128	W:W:?1	3.9	No	Yes	1	7	0
79	R:R:A129	R:R:M156	3.22	No	No	0	7	6
80	R:R:I130	R:R:Y297	7.25	Yes	No	0	8	9
81	R:R:M209	R:R:T131	4.52	No	No	0	8	8
82	R:R:L212	R:R:T131	2.95	Yes	No	0	5	8
83	R:R:T131	R:R:Y213	8.74	No	No	0	8	9
84	R:R:M156	R:R:V132	3.04	No	Yes	1	6	6
85	R:R:L212	R:R:V132	2.98	Yes	Yes	0	5	6
86	R:R:V132	W:W:?1	8.4	Yes	Yes	1	6	0
87	R:R:L212	R:R:Y135	3.52	Yes	Yes	0	5	8
88	R:R:Q215	R:R:Y135	15.78	Yes	Yes	1	6	8
89	R:R:I216	R:R:Y135	7.25	No	Yes	0	9	8
90	R:R:I219	R:R:Y135	3.63	No	Yes	0	6	8
91	R:R:Y135	S:S:Q215	3.38	Yes	Yes	1	8	6
92	R:R:L136	R:R:R152	9.72	No	No	0	5	6
93	R:R:L136	S:S:R218	2.43	No	No	1	5	4
94	R:R:L136	W:W:?1	9.76	No	Yes	1	5	0
95	R:R:S137	R:R:Y144	3.82	No	Yes	0	9	8
96	R:R:I219	R:R:L138	2.85	No	No	0	6	8
97	R:R:N140	R:R:Y139	6.98	No	No	0	5	6
98	R:R:Y139	S:S:H223	2.18	No	No	0	6	8
99	R:R:Y144	R:R:Y145	19.86	Yes	No	0	8	3
100	R:R:T149	R:R:Y144	9.99	No	Yes	7	8	8
101	R:R:E147	R:R:S146	7.19	No	No	0	4	4
102	R:R:R152	R:R:T148	3.88	No	No	0	6	6
103	R:R:R152	R:R:T149	3.88	No	No	0	6	8
104	R:R:V150	R:R:Y154	7.57	No	No	0	3	2
105	R:R:L159	R:R:V155	2.98	No	No	0	4	4
106	R:R:M156	W:W:?1	3.99	No	Yes	1	6	0
107	R:R:L157	R:R:W161	4.56	Yes	Yes	4	7	9
108	R:R:L159	W:W:?1	1.95	No	Yes	0	4	0
109	R:R:G162	R:R:G163	2.11	No	No	0	3	4
110	R:R:G166	R:R:L165	3.42	No	No	0	3	3
111	R:R:H194	R:R:L167	3.86	Yes	No	5	6	4
112	R:R:L167	R:R:L198	5.54	No	No	5	4	6
113	R:R:G168	R:R:P171	2.03	No	Yes	0	6	4
114	R:R:L169	R:R:L173	8.3	No	No	0	4	5
115	R:R:L170	R:R:P171	3.28	Yes	Yes	5	4	4
116	R:R:L170	R:R:L173	2.77	Yes	No	0	4	5
117	R:R:L170	R:R:W175	3.42	Yes	No	0	4	8
118	R:R:H194	R:R:L170	11.57	Yes	Yes	5	6	4
119	R:R:L190	R:R:P171	3.28	No	Yes	0	3	4
120	R:R:H194	R:R:P171	12.2	Yes	Yes	5	6	4
121	R:R:C177	R:R:C184	7.28	No	No	0	4	9
122	R:R:D179	R:R:G180	5.03	No	No	0	1	2
123	R:R:D179	R:R:L181	6.79	No	No	0	1	1
124	R:R:S191	R:R:T182	3.2	Yes	No	0	5	4
125	R:R:C184	R:R:G185	1.96	No	No	8	9	4
126	R:R:A272	R:R:C184	1.81	No	No	8	3	9
127	R:R:A272	R:R:G185	1.95	No	No	8	3	4
128	R:R:C267	R:R:V186	3.42	No	No	0	5	3
129	R:R:G270	R:R:V186	1.84	No	No	0	3	3
130	R:R:P189	R:R:V187	3.53	No	No	0	2	4
131	R:R:L190	R:R:V187	10.43	No	No	0	3	4
132	R:R:P189	R:R:Y188	2.78	No	No	0	2	1
133	R:R:L190	R:R:L195	2.77	No	No	0	3	4
134	R:R:N193	R:R:S191	2.98	No	Yes	0	3	5
135	R:R:K192	R:R:V196	3.04	No	No	0	2	5
136	R:R:H194	R:R:L198	5.14	Yes	No	5	6	6
137	R:R:C267	R:R:L195	6.35	No	No	0	5	4
138	R:R:V196	S:S:L268	4.47	No	No	0	5	5
139	R:R:A199	R:R:F203	2.77	No	Yes	2	4	5
140	R:R:A199	R:R:T264	3.36	No	No	2	4	6
141	R:R:A199	R:R:L268	4.73	No	Yes	2	4	5
142	R:R:I200	S:S:F203	12.56	No	No	0	4	5
143	R:R:I200	S:S:L268	2.85	No	No	0	4	5
144	R:R:F202	R:R:F203	5.36	Yes	Yes	2	7	5
145	R:R:F202	R:R:F256	3.22	Yes	Yes	2	7	8
146	R:R:F202	R:R:W260	3.01	Yes	Yes	2	7	8
147	R:R:F202	R:R:L261	2.44	Yes	Yes	2	7	4
148	R:R:F202	R:R:T264	9.08	Yes	No	2	7	6
149	R:R:F203	R:R:L261	2.44	Yes	Yes	2	5	4
150	R:R:F203	R:R:T264	2.59	Yes	No	2	5	6
151	R:R:F203	S:S:I200	11.3	Yes	No	2	5	4
152	R:R:F203	S:S:M204	3.73	Yes	No	0	5	4
153	R:R:M204	S:S:F206	2.49	No	Yes	0	4	6
154	R:R:F206	R:R:L210	8.53	No	No	0	6	4
155	R:R:F206	R:R:F256	3.22	No	Yes	0	6	8
156	R:R:F206	S:S:M204	7.46	No	No	0	6	4
157	R:R:G207	S:S:G207	2.11	No	No	0	4	4
158	R:R:I208	S:S:L210	4.28	Yes	No	0	6	4
159	R:R:I208	S:S:Q211	8.23	Yes	Yes	1	6	3
160	R:R:I208	W:W:?1	4.03	Yes	Yes	1	6	0
161	R:R:F256	R:R:M209	7.46	Yes	No	2	8	8
162	R:R:Q211	R:R:Q215	7.68	Yes	Yes	0	3	6
163	R:R:Q211	S:S:Q211	7.68	Yes	Yes	0	3	3
164	R:R:Q211	S:S:L212	5.32	Yes	Yes	0	3	5
165	R:R:Q211	X:X:?1	11.26	Yes	Yes	0	3	0
166	R:R:L212	S:S:Q211	13.31	Yes	Yes	0	5	3
167	R:R:I216	R:R:Y213	2.42	No	No	0	9	9
168	R:R:L249	R:R:Y213	8.21	No	No	0	7	9
169	R:R:A214	X:X:?1	2.22	No	Yes	0	2	0
170	R:R:Q215	S:S:Y135	5.64	Yes	Yes	1	6	8
171	R:R:Q215	S:S:Q215	15.36	Yes	Yes	1	6	6
172	R:R:C217	R:R:I246	4.91	No	No	0	7	7
173	R:R:R218	S:S:R152	4.26	No	Yes	1	4	6
174	R:R:R218	X:X:?1	15.42	No	Yes	1	4	0
175	R:R:H223	R:R:I219	2.65	No	No	0	8	6
176	R:R:G245	R:R:V220	1.84	No	No	0	7	8
177	R:R:L229	R:R:Q225	2.66	No	No	0	4	4
178	R:R:L229	R:R:Q226	2.66	No	No	0	4	5
179	R:R:I246	R:R:R243	7.52	No	No	0	7	5
180	R:R:F256	R:R:W260	3.01	Yes	Yes	2	8	8
181	R:R:C259	R:R:N289	11.02	No	No	0	8	9
182	R:R:F263	R:R:W260	2	No	Yes	0	5	8
183	R:R:A286	R:R:W260	2.59	No	Yes	0	6	8
184	R:R:N289	R:R:W260	6.78	No	Yes	0	9	8
185	R:R:L261	R:R:V265	4.47	Yes	No	0	4	5
186	R:R:F263	R:R:T282	2.59	No	No	0	5	4
187	R:R:Y266	R:R:Y278	2.98	No	No	0	3	4
188	R:R:L268	S:S:V196	2.98	Yes	No	2	5	5
189	R:R:L268	S:S:I200	2.85	Yes	No	2	5	4
190	R:R:L268	S:S:L268	4.15	Yes	No	0	5	5
191	R:R:L269	S:S:N193	5.49	No	No	0	4	3
192	R:R:D271	R:R:H273	17.65	No	No	0	5	1
193	R:R:P275	R:R:S274	3.56	No	No	0	4	2
194	R:R:P275	R:R:P276	1.95	No	No	0	4	1
195	R:R:P275	R:R:Y278	9.74	No	No	0	4	4
196	R:R:L277	R:R:Y278	3.52	No	No	0	1	4
197	R:R:L277	R:R:L281	2.77	No	No	0	1	3
198	R:R:L284	R:R:P285	4.93	No	No	0	4	7
199	R:R:L284	R:R:Y288	3.52	No	No	0	4	5
200	R:R:M291	R:R:Y288	8.38	No	No	0	6	5
201	R:R:N293	R:R:P294	3.26	Yes	Yes	0	9	9
202	R:R:N293	R:R:Y297	5.81	Yes	No	0	9	9
203	R:R:F299	R:R:I295	3.77	No	No	0	5	6
204	R:R:I296	R:R:Y297	4.84	No	No	0	8	9
205	R:R:F299	R:R:L308	2.44	No	No	0	5	6
206	R:R:D303	R:R:N301	4.04	No	No	0	6	8
207	R:R:Q302	R:R:Q305	6.4	No	No	0	5	8
208	R:R:Q305	R:R:W309	5.48	No	No	0	8	4
209	S:S:F101	S:S:P38	4.33	Yes	No	0	5	6
210	S:S:F101	S:S:P40	11.56	Yes	No	0	5	4
211	S:S:W43	S:S:Y280	6.75	No	No	0	6	3
212	S:S:D44	S:S:F97	2.39	No	Yes	10	8	5
213	S:S:D44	S:S:F101	10.75	No	Yes	10	8	5
214	S:S:D44	S:S:Y280	6.9	No	No	0	8	3
215	S:S:I49	S:S:V45	3.07	No	No	0	3	7
216	S:S:F97	S:S:V45	2.62	Yes	No	0	5	7
217	S:S:C48	S:S:V94	5.12	No	No	0	3	7
218	S:S:C48	S:S:F97	15.36	No	Yes	0	3	5
219	S:S:G51	S:S:S50	1.86	Yes	No	0	6	5
220	S:S:S50	S:S:T287	9.59	No	No	0	5	6
221	S:S:G51	S:S:V54	1.84	Yes	Yes	3	6	7
222	S:S:G51	S:S:G90	2.11	Yes	Yes	3	6	8
223	S:S:G51	S:S:V94	1.84	Yes	No	0	6	7
224	S:S:T52	S:S:V94	6.35	No	No	0	5	7
225	S:S:N58	S:S:V54	2.96	Yes	Yes	3	9	7
226	S:S:D86	S:S:V54	4.38	Yes	Yes	3	9	7
227	S:S:G90	S:S:V54	1.84	Yes	Yes	3	8	7
228	S:S:M291	S:S:V54	3.04	No	Yes	0	6	7
229	S:S:L87	S:S:S55	3	No	No	0	7	6
230	S:S:G90	S:S:S55	1.86	Yes	No	0	8	6
231	S:S:E57	S:S:L60	5.3	No	No	0	7	8
232	S:S:E57	S:S:I295	5.47	No	No	0	7	6
233	S:S:D86	S:S:N58	13.46	Yes	Yes	3	9	9
234	S:S:L87	S:S:N58	6.87	No	Yes	0	7	9
235	S:S:N58	S:S:P294	3.26	Yes	No	3	9	9
236	S:S:L60	S:S:V61	2.98	No	No	0	8	9
237	S:S:I64	S:S:V304	7.68	No	No	0	7	8
238	S:S:I64	S:S:V307	3.07	No	No	0	7	7
239	S:S:I64	S:S:L308	11.42	No	No	0	7	6
240	S:S:G67	S:S:V66	1.84	No	No	0	6	3
241	S:S:P69	S:S:T68	3.5	No	Yes	0	5	6
242	S:S:F71	S:S:T68	16.86	Yes	Yes	6	9	6
243	S:S:T68	S:S:V307	6.35	Yes	No	6	6	7
244	S:S:F71	S:S:F76	16.08	Yes	No	6	9	9
245	S:S:D303	S:S:F71	8.36	No	Yes	6	6	9
246	S:S:F71	S:S:V307	2.62	Yes	No	6	9	7
247	S:S:A73	S:S:P74	1.87	No	Yes	0	7	6
248	S:S:A73	S:S:F76	8.32	No	No	0	7	9
249	S:S:D133	S:S:P74	4.83	No	Yes	1	9	6
250	S:S:P74	S:S:Y144	4.17	Yes	Yes	1	6	8
251	S:S:P74	S:S:T149	3.5	Yes	No	1	6	8
252	S:S:M75	S:S:V79	3.04	No	No	0	8	7
253	S:S:I130	S:S:M75	2.92	No	No	0	8	8
254	S:S:M75	S:S:R134	4.96	No	No	0	8	9
255	S:S:D303	S:S:F76	13.14	No	No	6	6	9
256	S:S:L77	S:S:Y154	2.34	No	Yes	0	4	2
257	S:S:I130	S:S:L78	8.56	No	No	0	8	8
258	S:S:D133	S:S:L78	5.43	No	No	0	9	8
259	S:S:L78	S:S:T153	2.95	No	No	0	8	6
260	S:S:A298	S:S:V79	5.09	No	No	0	8	7
261	S:S:S126	S:S:S81	4.89	No	No	0	8	9
262	S:S:L157	S:S:S81	3	No	No	11	7	9
263	S:S:S81	S:S:W161	6.18	No	No	11	9	9
264	S:S:L82	S:S:S123	3	No	No	0	9	9
265	S:S:L82	S:S:Y297	2.34	No	No	0	9	9
266	S:S:A122	S:S:A85	1.79	No	No	0	7	8
267	S:S:D86	S:S:S290	5.89	Yes	No	0	9	9
268	S:S:D86	S:S:P294	3.22	Yes	No	3	9	9
269	S:S:L88	S:S:V115	4.47	No	No	0	7	3
270	S:S:A119	S:S:L88	4.73	No	No	0	6	7
271	S:S:A89	S:S:G90	1.95	No	Yes	0	8	8
272	S:S:A119	S:S:A89	1.79	No	No	0	6	8
273	S:S:L116	S:S:L93	5.54	No	No	0	5	6
274	S:S:L112	S:S:L95	4.15	No	No	0	5	7
275	S:S:H96	S:S:V100	2.77	Yes	No	0	5	4
276	S:S:H96	S:S:S109	6.97	Yes	No	0	5	9
277	S:S:H96	S:S:L112	6.43	Yes	No	0	5	5
278	S:S:H96	S:S:V113	2.77	Yes	No	0	5	5
279	S:S:F101	S:S:F97	7.5	Yes	Yes	10	5	5
280	S:S:A99	S:S:S105	3.42	No	Yes	0	4	6
281	S:S:F101	S:S:V100	11.8	Yes	No	0	5	4
282	S:S:S105	S:S:V100	3.23	Yes	No	0	6	4
283	S:S:G104	S:S:I103	3.53	No	No	0	4	5
284	S:S:I103	S:S:S105	3.1	No	Yes	0	5	6
285	S:S:M108	S:S:S105	3.07	No	Yes	0	4	6
286	S:S:E107	S:S:M108	4.06	No	No	0	1	4
287	S:S:L112	S:S:M108	5.65	No	No	0	5	4
288	S:S:L110	S:S:V172	2.98	No	No	0	4	5
289	S:S:G114	S:S:P171	4.06	No	No	0	6	4
290	S:S:F120	S:S:L116	7.31	Yes	No	0	5	5
291	S:S:F120	S:S:W260	10.02	Yes	Yes	12	5	8
292	S:S:A286	S:S:F120	4.16	No	Yes	12	6	5
293	S:S:F120	S:S:S290	3.96	Yes	No	0	5	9
294	S:S:A164	S:S:T121	3.36	No	No	0	8	6
295	S:S:L167	S:S:T121	5.9	No	No	0	4	6
296	S:S:A122	S:S:W161	3.89	No	No	0	7	9
297	S:S:A122	S:S:A164	1.79	No	No	0	7	8
298	S:S:F256	S:S:I124	3.77	Yes	No	0	8	7
299	S:S:I124	S:S:W260	5.87	No	Yes	0	7	8
300	S:S:G125	S:S:V160	1.84	No	No	0	4	6
301	S:S:L127	S:S:T131	2.95	Yes	No	0	8	8
302	S:S:F256	S:S:L127	2.44	Yes	Yes	0	8	8
303	S:S:L127	S:S:N293	4.12	Yes	No	0	8	9
304	S:S:L127	S:S:Y297	9.38	Yes	No	0	8	9
305	S:S:L128	S:S:V132	2.98	Yes	Yes	1	7	6
306	S:S:I208	S:S:L128	4.28	No	Yes	1	6	7
307	S:S:L128	S:S:M209	2.83	Yes	Yes	1	7	8
308	S:S:L128	X:X:?1	5.86	Yes	Yes	1	7	0
309	S:S:A129	S:S:M156	4.83	No	Yes	0	7	6
310	S:S:I130	S:S:Y297	7.25	No	No	0	8	9
311	S:S:L212	S:S:T131	2.95	Yes	No	0	5	8
312	S:S:T131	S:S:Y213	4.99	No	Yes	0	8	9
313	S:S:M156	S:S:V132	3.04	Yes	Yes	1	6	6
314	S:S:L212	S:S:V132	2.98	Yes	Yes	0	5	6
315	S:S:V132	X:X:?1	14.71	Yes	Yes	1	6	0
316	S:S:D133	S:S:Y144	8.05	No	Yes	1	9	8
317	S:S:L136	S:S:Y135	3.52	Yes	Yes	1	5	8
318	S:S:Y135	S:S:Y139	1.99	Yes	No	0	8	6
319	S:S:L212	S:S:Y135	2.34	Yes	Yes	0	5	8
320	S:S:Q215	S:S:Y135	12.4	Yes	Yes	1	6	8
321	S:S:I216	S:S:Y135	6.04	No	Yes	0	9	8
322	S:S:L136	S:S:Y144	2.34	Yes	Yes	1	5	8
323	S:S:L136	S:S:R152	12.15	Yes	Yes	1	5	6
324	S:S:L136	X:X:?1	13.66	Yes	Yes	1	5	0
325	S:S:S137	S:S:Y144	6.36	No	Yes	0	9	8
326	S:S:I219	S:S:L138	2.85	No	No	0	6	8
327	S:S:N140	S:S:Y139	8.14	No	No	0	5	6
328	S:S:I219	S:S:Y139	2.42	No	No	0	6	6
329	S:S:N140	S:S:T143	7.31	No	No	0	5	5
330	S:S:Y144	S:S:Y145	2.98	Yes	No	0	8	3
331	S:S:T149	S:S:Y144	17.48	No	Yes	1	8	8
332	S:S:R152	S:S:Y144	3.09	Yes	Yes	1	6	8
333	S:S:S146	S:S:T148	6.4	No	No	0	4	6
334	S:S:E147	S:S:T151	4.23	No	No	0	4	4
335	S:S:V150	S:S:Y154	8.83	No	Yes	0	3	2
336	S:S:M156	S:S:R152	3.72	Yes	Yes	1	6	6
337	S:S:R152	X:X:?1	3.43	Yes	Yes	1	6	0
338	S:S:T153	S:S:Y154	2.5	No	Yes	0	6	2
339	S:S:L159	S:S:V155	2.98	No	No	1	4	4
340	S:S:V155	X:X:?1	4.2	No	Yes	1	4	0
341	S:S:M156	X:X:?1	7.97	Yes	Yes	1	6	0
342	S:S:L157	S:S:W161	2.28	No	No	11	7	9
343	S:S:L159	X:X:?1	1.95	No	Yes	1	4	0
344	S:S:G162	S:S:G163	2.11	No	No	0	3	4
345	S:S:G166	S:S:L165	3.42	No	No	0	3	3
346	S:S:G168	S:S:P171	2.03	No	No	0	6	4
347	S:S:L169	S:S:L173	5.54	No	No	0	4	5
348	S:S:L170	S:S:L173	2.77	No	No	0	4	5
349	S:S:L170	S:S:W175	2.28	No	No	0	4	8
350	S:S:H194	S:S:L170	11.57	No	No	0	6	4
351	S:S:H194	S:S:P171	7.63	No	No	0	6	4
352	S:S:S191	S:S:W175	8.65	No	No	9	5	8
353	S:S:N193	S:S:W175	2.26	No	No	9	3	8
354	S:S:L178	S:S:N176	4.12	No	No	0	1	5
355	S:S:C177	S:S:C184	7.28	No	No	0	4	9
356	S:S:S191	S:S:T182	3.2	No	No	0	5	4
357	S:S:D271	S:S:T183	4.34	No	No	0	5	4
358	S:S:C184	S:S:G185	1.96	No	No	0	9	4
359	S:S:C267	S:S:V186	3.42	No	No	0	5	3
360	S:S:T279	S:S:V186	4.76	No	No	0	1	3
361	S:S:L190	S:S:V187	4.47	No	No	0	3	4
362	S:S:P189	S:S:Y188	2.78	No	No	0	2	1
363	S:S:L190	S:S:P189	4.93	No	No	0	3	2
364	S:S:H194	S:S:L190	2.57	No	No	0	6	3
365	S:S:N193	S:S:S191	2.98	No	No	9	3	5
366	S:S:D271	S:S:K192	2.77	No	No	0	5	2
367	S:S:C267	S:S:L195	11.11	No	No	0	5	4
368	S:S:I200	S:S:V196	3.07	No	No	2	4	5
369	S:S:F202	S:S:F203	2.14	Yes	No	1	7	5
370	S:S:F202	S:S:F206	3.22	Yes	Yes	1	7	6
371	S:S:F202	S:S:F256	3.22	Yes	Yes	1	7	8
372	S:S:F202	S:S:L261	2.44	Yes	No	1	7	4
373	S:S:F202	S:S:T264	10.38	Yes	No	0	7	6
374	S:S:F203	S:S:L261	2.44	No	No	1	5	4
375	S:S:F206	S:S:M209	2.49	Yes	Yes	1	6	8
376	S:S:F206	S:S:F256	4.29	Yes	Yes	1	6	8
377	S:S:A257	S:S:F206	2.77	No	Yes	0	5	6
378	S:S:I208	X:X:?1	14.09	No	Yes	1	6	0
379	S:S:M209	S:S:Y213	7.18	Yes	Yes	1	8	9
380	S:S:L253	S:S:M209	2.83	No	Yes	1	7	8
381	S:S:F256	S:S:M209	3.73	Yes	Yes	1	8	8
382	S:S:Q211	S:S:Q215	2.56	Yes	Yes	1	3	6
383	S:S:Q211	W:W:?1	18.77	Yes	Yes	1	3	0
384	S:S:L249	S:S:Y213	5.86	No	Yes	0	7	9
385	S:S:V252	S:S:Y213	2.52	No	Yes	0	8	9
386	S:S:L253	S:S:Y213	10.55	No	Yes	1	7	9
387	S:S:Q215	W:W:?1	9.38	Yes	Yes	1	6	0
388	S:S:C217	S:S:I246	3.27	No	No	0	7	7
389	S:S:R218	W:W:?1	10.28	No	Yes	1	4	0
390	S:S:H223	S:S:R222	2.26	No	No	0	8	6
391	S:S:C259	S:S:N289	3.15	No	No	0	8	9
392	S:S:F263	S:S:W260	11.02	No	Yes	0	5	8
393	S:S:A286	S:S:W260	9.08	No	Yes	12	6	8
394	S:S:N289	S:S:W260	6.78	No	Yes	0	9	8
395	S:S:Y266	S:S:Y278	7.94	No	No	0	3	4
396	S:S:T282	S:S:Y266	8.74	No	No	0	4	3
397	S:S:A272	S:S:D271	4.63	No	No	0	3	5
398	S:S:A272	S:S:H273	2.93	No	No	0	3	1
399	S:S:P275	S:S:P276	1.95	No	No	0	4	1
400	S:S:P275	S:S:Y278	11.13	No	No	0	4	4
401	S:S:L277	S:S:Y278	2.34	No	No	0	1	4
402	S:S:L284	S:S:Y288	9.38	No	No	0	4	5
403	S:S:T287	S:S:Y288	3.75	No	No	0	6	5
404	S:S:N289	S:S:N293	8.17	No	No	0	9	9
405	S:S:I292	S:S:M291	2.92	No	No	0	5	6
406	S:S:F299	S:S:V304	5.24	No	No	0	5	8
407	S:S:D303	S:S:N301	4.04	No	No	0	6	8
408	S:S:Q302	S:S:Q305	2.56	No	No	0	5	8
409	S:S:Q305	S:S:W309	2.19	No	No	0	8	4
410	S:S:L308	S:S:W309	2.28	No	No	0	6	4
411	W:W:?1	W:W:?2	13.76	Yes	No	0	0	0
412	X:X:?1	X:X:?2	13.76	Yes	No	0	0	0
413	S:S:P40	S:S:S39	1.78	No	No	0	4	5
414	S:S:P275	S:S:S274	1.78	No	No	0	4	2
415	R:R:P294	R:R:V61	1.77	Yes	Yes	0	9	9
416	R:R:G125	R:R:I124	1.76	No	No	0	4	7
417	R:R:G207	S:S:I208	1.76	No	No	0	4	6
418	R:R:I208	S:S:G207	1.76	Yes	No	0	6	4
419	R:R:G245	R:R:I246	1.76	No	No	0	7	7
420	R:R:P69	R:R:T68	1.75	No	Yes	0	5	6
421	R:R:G168	R:R:M118	1.75	No	No	0	6	5
422	S:S:G168	S:S:M118	1.75	No	No	0	6	5
423	S:S:P262	S:S:T282	1.75	No	No	0	9	4
424	S:S:G185	S:S:K192	1.74	No	No	0	4	2
425	R:R:C177	R:R:S191	1.72	No	Yes	0	4	5
426	R:R:C48	R:R:V94	1.71	No	No	0	3	7
427	R:R:G51	R:R:L93	1.71	No	No	0	6	6
428	R:R:G90	R:R:L93	1.71	No	No	0	8	6
429	R:R:G92	R:R:L91	1.71	No	No	0	5	4
430	R:R:G92	R:R:L112	1.71	No	No	0	5	5
431	R:R:G92	R:R:L116	1.71	No	No	0	5	5
432	R:R:A106	R:R:S109	1.71	No	No	0	1	9
433	R:R:G162	R:R:L165	1.71	No	No	0	3	3
434	R:R:G166	R:R:L169	1.71	No	No	0	3	4
435	R:R:G254	R:R:L253	1.71	No	No	0	5	7
436	S:S:G92	S:S:L91	1.71	No	No	0	5	4
437	S:S:G162	S:S:L165	1.71	No	No	0	3	3
438	S:S:G168	S:S:L167	1.71	No	No	0	6	4
439	S:S:G180	S:S:L181	1.71	No	No	0	2	1
440	S:S:G254	S:S:L253	1.71	No	No	0	5	7
441	S:S:G270	S:S:L269	1.71	No	No	0	3	4
442	R:R:A83	R:R:V61	1.7	No	Yes	0	9	9
443	R:R:A298	R:R:V61	1.7	No	Yes	0	8	9
444	R:R:A83	R:R:V62	1.7	No	No	0	9	8
445	R:R:A298	R:R:V79	1.7	No	No	0	8	7
446	S:S:A129	S:S:V160	1.7	No	No	0	7	6
447	S:S:C56	S:S:T52	1.69	No	No	0	5	5
448	R:R:A70	R:R:T68	1.68	No	Yes	0	6	6
449	S:S:A70	S:S:T68	1.68	No	Yes	0	6	6
450	S:S:A199	S:S:T264	1.68	No	No	0	4	6
451	R:R:L261	R:R:P262	1.64	Yes	No	0	4	9
452	S:S:L37	S:S:P38	1.64	No	No	0	4	6
453	S:S:L261	S:S:P262	1.64	No	No	0	4	9
454	S:S:L284	S:S:P285	1.64	No	No	0	4	7
455	R:R:S274	R:R:V186	1.62	No	No	0	2	3
456	S:S:S126	S:S:V160	1.62	No	No	0	8	6
457	R:R:S50	R:R:T287	1.6	No	No	0	5	6
458	R:R:V62	R:R:V84	1.6	No	No	0	8	7
459	R:R:V111	R:R:V115	1.6	No	No	0	4	3
460	S:S:V62	S:S:V84	1.6	No	No	0	8	7
461	R:R:T52	R:R:V94	1.59	No	No	0	5	7
462	R:R:T287	R:R:V54	1.59	No	No	0	6	7
463	R:R:T151	R:R:V155	1.59	No	No	0	4	4
464	R:R:T279	R:R:V187	1.59	No	No	0	1	4
465	R:R:C217	R:R:L249	1.59	No	No	0	7	7
466	R:R:T248	R:R:V252	1.59	No	No	0	9	8
467	S:S:T279	S:S:V187	1.59	No	No	0	1	4
468	S:S:T248	S:S:V252	1.59	No	No	0	9	8
469	R:R:A59	R:R:L87	1.58	No	No	0	4	7
470	R:R:A286	R:R:L283	1.58	No	No	0	6	4
471	S:S:A174	S:S:L173	1.58	No	No	0	6	5
472	S:S:A286	S:S:L283	1.58	No	No	0	6	4
473	R:R:E57	R:R:P294	1.57	No	Yes	0	7	9
474	S:S:C177	S:S:N176	1.57	No	No	0	4	5
475	R:R:I49	R:R:V45	1.54	No	No	0	3	7
476	R:R:I65	R:R:V61	1.54	No	Yes	0	7	9
477	R:R:I64	R:R:V307	1.54	No	No	0	7	7
478	R:R:I65	R:R:V304	1.54	No	No	0	7	8
479	R:R:I200	S:S:V265	1.54	No	No	0	4	5
480	R:R:I296	R:R:V252	1.54	No	No	0	8	8
481	S:S:I65	S:S:V304	1.54	No	No	0	7	8
482	S:S:I216	S:S:V220	1.54	No	No	0	9	8
483	R:R:K192	R:R:S191	1.53	No	Yes	0	2	5
484	S:S:K41	S:S:S39	1.53	No	No	0	5	5
485	R:R:I49	R:R:T52	1.52	No	No	0	3	5
486	S:S:K192	S:S:V196	1.52	No	No	0	2	5
487	S:S:L91	S:S:S55	1.5	No	No	0	4	6
488	R:R:L284	R:R:V46	1.49	No	No	0	4	5
489	R:R:L91	R:R:V94	1.49	No	No	0	4	7
490	R:R:V196	S:S:L269	1.49	No	No	0	5	4
491	S:S:L110	S:S:V111	1.49	No	No	0	4	4
492	S:S:L128	S:S:V205	1.49	Yes	No	0	7	7
493	S:S:L269	S:S:V265	1.49	No	No	0	4	5
494	R:R:L47	R:R:T287	1.47	No	No	0	5	6
495	R:R:L181	R:R:T182	1.47	No	No	0	1	4
496	R:R:I292	R:R:I296	1.47	No	No	0	5	8
497	S:S:L47	S:S:T287	1.47	No	No	0	5	6
498	S:S:L198	S:S:T121	1.47	No	No	0	6	6
499	S:S:I292	S:S:I296	1.47	No	No	0	5	8
500	S:S:I295	S:S:I296	1.47	No	No	0	6	8
501	R:R:N140	R:R:T143	1.46	No	No	0	5	5
502	R:R:A272	R:R:H273	1.46	No	No	0	3	1
503	S:S:I49	S:S:L53	1.43	No	No	0	3	5
504	S:S:E107	S:S:V111	1.43	No	No	0	1	4
505	S:S:C221	S:S:R218	1.39	No	No	0	6	4
506	R:R:L157	R:R:L77	1.38	Yes	No	0	7	4
507	R:R:L210	R:R:L253	1.38	No	No	0	4	7
508	S:S:L165	S:S:L169	1.38	No	No	0	3	4
509	R:R:L87	R:R:N58	1.37	No	No	0	7	9
510	R:R:L178	R:R:N176	1.37	No	No	0	1	5
511	S:S:H223	S:S:I219	1.33	No	No	0	8	6
512	R:R:N301	R:R:Q302	1.32	No	No	0	8	5
513	R:R:R72	R:R:V66	1.31	No	No	0	8	3
514	R:R:A174	R:R:W175	1.3	No	No	0	6	8
515	S:S:R300	S:S:T248	1.29	No	No	0	7	9
516	R:R:T153	R:R:Y154	1.25	No	No	0	6	2
517	R:R:Q226	R:R:R222	1.17	No	No	0	5	6
518	R:R:H223	R:R:R222	1.13	No	No	0	8	6
519	S:S:R72	S:S:Y154	1.03	No	Yes	0	8	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V61	1.866	5	0	9
2	R:R:T68	2.935	4	0	6
3	R:R:F71	8.4475	4	0	9
4	R:R:L78	3.545	4	0	8
5	R:R:L82	6.665	4	0	9
6	R:R:D86	7.325	4	0	9
7	R:R:F101	10.3525	4	0	5
8	R:R:I130	4.325	4	0	8
9	R:R:V132	4.35	4	1	6
10	R:R:Y135	6.712	5	1	8
11	R:R:Y144	9.46	4	7	8
12	R:R:L157	4.43	4	4	7
13	R:R:W161	4.418	5	4	9
14	R:R:L170	5.26	4	5	4
15	R:R:P171	5.1975	4	5	4
16	R:R:S191	2.3575	4	0	5
17	R:R:H194	8.1925	4	5	6
18	R:R:F202	4.622	5	2	7
19	R:R:F203	4.69833	6	2	5
20	R:R:I208	4.575	4	1	6
21	R:R:Q211	7.985	4	0	3
22	R:R:L212	5.69	4	0	5
23	R:R:Q215	11.115	4	1	6
24	R:R:F256	4.04833	6	2	8
25	R:R:W260	4.99714	7	2	8
26	R:R:L261	2.7475	4	2	4
27	R:R:L268	3.6775	4	2	5
28	R:R:N293	6.73	4	0	9
29	R:R:P294	2.465	4	0	9
30	S:S:G51	1.9125	4	3	6
31	S:S:V54	2.812	5	3	7
32	S:S:N58	6.6375	4	3	9
33	S:S:T68	7.0975	4	6	6
34	S:S:F71	10.98	4	6	9
35	S:S:P74	3.5925	4	1	6
36	S:S:D86	6.7375	4	3	9
37	S:S:G90	1.94	4	3	8
38	S:S:H96	4.735	4	0	5
39	S:S:F97	6.9675	4	10	5
40	S:S:F101	9.188	5	10	5
41	S:S:S105	3.205	4	0	6
42	S:S:F120	6.3625	4	12	5
43	S:S:L127	4.7225	4	0	8
44	S:S:L128	3.488	5	1	7
45	S:S:V132	5.9275	4	1	6
46	S:S:Y135	5.32167	6	1	8
47	S:S:L136	7.9175	4	1	5
48	S:S:Y144	6.35286	7	1	8
49	S:S:R152	5.33	5	1	6
50	S:S:Y154	3.675	4	0	2
51	S:S:M156	4.89	4	1	6
52	S:S:F202	4.28	5	1	7
53	S:S:F206	3.052	5	1	6
54	S:S:M209	3.812	5	1	8
55	S:S:Q211	10.11	5	1	3
56	S:S:L212	3.3975	4	0	5
57	S:S:Y213	6.22	5	1	9
58	S:S:Q215	8.616	5	1	6
59	S:S:F256	3.49	5	1	8
60	S:S:W260	8.554	5	12	8
61	W:W:?1	8.422	10	1	0
62	X:X:?1	9.04417	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C48	R:R:F97	10.5384	16.76	No	No	0	3	5
2	R:R:C48	R:R:V94	11.4025	1.71	No	No	0	3	7
3	R:R:L91	R:R:V94	14.8372	1.49	No	No	0	4	7
4	R:R:G92	R:R:L91	15.6904	1.71	No	No	0	5	4
5	R:R:G92	R:R:L112	22.4374	1.71	No	No	0	5	5
6	R:R:H96	R:R:L112	24.1023	6.43	No	No	0	5	5
7	R:R:H96	R:R:V113	26.5834	2.77	No	No	0	5	5
8	R:R:P189	R:R:V113	27.406	3.53	No	No	0	2	5
9	R:R:P189	R:R:V187	29.0448	3.53	No	No	0	2	4
10	R:R:L190	R:R:V187	30.6748	10.43	No	No	0	3	4
11	R:R:L190	R:R:P171	40.2717	3.28	No	Yes	0	3	4
12	R:R:H194	R:R:P171	43.6572	12.2	Yes	Yes	5	6	4
13	R:R:H194	R:R:L167	51.732	3.86	Yes	No	5	6	4
14	R:R:L167	R:R:T121	53.2966	7.37	No	No	0	4	6
15	R:R:A164	R:R:T121	54.0451	3.36	No	No	0	8	6
16	R:R:A122	R:R:A164	54.7913	1.79	No	No	0	7	8
17	R:R:A122	R:R:W161	55.4612	6.48	No	Yes	4	7	9
18	R:R:S81	R:R:W161	56.5796	6.18	No	Yes	4	9	9
19	R:R:S126	R:R:S81	58.9111	4.89	No	No	0	8	9
20	R:R:L82	R:R:S126	59.64	6.01	Yes	No	0	9	8
21	R:R:D86	R:R:L82	11.1734	4.07	Yes	Yes	0	9	9
22	R:R:L82	R:R:N293	76.3428	13.73	Yes	Yes	0	9	9
23	R:R:N293	R:R:P294	19.9465	3.26	Yes	Yes	0	9	9
24	R:R:P294	R:R:V61	16.7618	1.77	Yes	Yes	0	9	9
25	R:R:A73	R:R:F76	11.2902	4.16	No	No	0	7	9
26	R:R:A73	R:R:P74	11.7255	1.87	No	No	0	7	6
27	R:R:L127	R:R:N293	100	4.12	No	Yes	0	8	9
28	R:R:L127	R:R:M209	78.5358	2.83	No	No	2	8	8
29	R:R:M209	R:R:T131	93.1373	4.52	No	No	0	8	8
30	R:R:L212	R:R:T131	94.2436	2.95	Yes	No	0	5	8
31	R:R:L136	W:W:?1	19.3203	9.76	No	Yes	1	5	0
32	R:R:L136	R:R:R152	18.19	9.72	No	No	0	5	6
33	R:R:R152	R:R:T149	15.8638	3.88	No	No	0	6	8
34	R:R:L212	S:S:Q211	72.9038	13.31	Yes	Yes	0	5	3
35	S:S:Q211	W:W:?1	17.4055	18.77	Yes	Yes	1	3	0
36	R:R:P74	R:R:T149	12.0244	3.5	No	No	7	6	8
37	R:R:I130	R:R:L78	11.696	4.28	Yes	Yes	0	8	8
38	R:R:F256	R:R:L127	22.0381	4.87	Yes	No	2	8	8
39	R:R:L212	R:R:Y135	17.8266	3.52	Yes	Yes	0	5	8
40	R:R:Q215	R:R:Y135	17.7623	15.78	Yes	Yes	1	6	8
41	R:R:Y135	S:S:Q215	12.391	3.38	Yes	Yes	1	8	6
42	R:R:Q215	S:S:Y135	11.9033	5.64	Yes	Yes	1	6	8
43	S:S:Y135	S:S:Y139	10.7806	1.99	Yes	No	0	8	6
44	S:S:Q215	S:S:Y135	29.3557	12.4	Yes	Yes	1	6	8
45	R:R:K192	R:R:S191	16.1028	1.53	No	Yes	0	2	5
46	R:R:K192	R:R:V196	17.4306	3.04	No	No	0	2	5
47	R:R:V196	S:S:L268	20.0415	4.47	No	No	0	5	5
48	R:R:L268	S:S:L268	33.6403	4.15	Yes	No	0	5	5
49	R:R:A199	R:R:L268	18.5042	4.73	No	Yes	2	4	5
50	R:R:A199	R:R:F203	10.0289	2.77	No	Yes	2	4	5
51	R:R:F202	R:R:F203	21.2449	5.36	Yes	Yes	2	7	5
52	R:R:F202	R:R:F256	28.077	3.22	Yes	Yes	2	7	8
53	R:R:L268	S:S:I200	10.0267	2.85	Yes	No	2	5	4
54	R:R:F203	S:S:I200	13.3784	11.3	Yes	No	2	5	4
55	R:R:I200	S:S:L268	29.1703	2.85	No	No	0	4	5
56	R:R:I200	S:S:F203	30.4511	12.56	No	No	0	4	5
57	R:R:Q211	S:S:Q211	76.4803	7.68	Yes	Yes	0	3	3
58	R:R:Q211	X:X:?1	44.1056	11.26	Yes	Yes	0	3	0
59	S:S:L128	X:X:?1	39.0039	5.86	Yes	Yes	1	7	0
60	S:S:L128	S:S:M209	47.4628	2.83	Yes	Yes	1	7	8
61	S:S:F206	S:S:M209	10.1915	2.49	Yes	Yes	1	6	8
62	R:R:Q211	S:S:L212	39.1326	5.32	Yes	Yes	0	3	5
63	S:S:R152	X:X:?1	10.2624	3.43	Yes	Yes	1	6	0
64	S:S:H194	S:S:L170	10.1718	11.57	No	No	0	6	4
65	S:S:H194	S:S:P171	17.0062	7.63	No	No	0	6	4
66	S:S:G168	S:S:P171	18.5009	2.03	No	No	0	6	4
67	S:S:G168	S:S:L167	19.9869	1.71	No	No	0	6	4
68	S:S:L167	S:S:T121	20.7266	5.9	No	No	0	4	6
69	S:S:A164	S:S:T121	22.1886	3.36	No	No	0	8	6
70	S:S:A122	S:S:A164	22.9218	1.79	No	No	0	7	8
71	S:S:A122	S:S:W161	24.3816	3.89	No	No	0	7	9
72	S:S:S81	S:S:W161	25.0723	6.18	No	No	11	9	9
73	S:S:S126	S:S:S81	26.555	4.89	No	No	0	8	9
74	S:S:S126	S:S:V160	27.2751	1.62	No	No	0	8	6
75	S:S:A129	S:S:V160	28.7087	1.7	No	No	0	7	6
76	S:S:A129	S:S:M156	29.4223	4.83	No	Yes	0	7	6
77	S:S:M156	X:X:?1	18.933	7.97	Yes	Yes	1	6	0
78	S:S:L212	S:S:T131	56.5501	2.95	Yes	No	0	5	8
79	S:S:L127	S:S:T131	53.7417	2.95	Yes	No	0	8	8
80	S:S:F256	S:S:L127	31.6644	2.44	Yes	Yes	0	8	8
81	S:S:F256	S:S:I124	62.2137	3.77	Yes	No	0	8	7
82	S:S:I124	S:S:W260	61.4369	5.87	No	Yes	0	7	8
83	S:S:F120	S:S:W260	81.7708	10.02	Yes	Yes	12	5	8
84	S:S:F120	S:S:S290	78.4573	3.96	Yes	No	0	5	9
85	S:S:D86	S:S:S290	77.3313	5.89	Yes	No	0	9	9
86	S:S:D86	S:S:V54	68.7622	4.38	Yes	Yes	3	9	7
87	S:S:G51	S:S:V54	49.2281	1.84	Yes	Yes	3	6	7
88	S:S:G51	S:S:V94	40.9503	1.84	Yes	No	0	6	7
89	S:S:C48	S:S:V94	37.2058	5.12	No	No	0	3	7
90	S:S:C48	S:S:F97	35.9533	15.36	No	Yes	0	3	5
91	S:S:F101	S:S:F97	27.058	7.5	Yes	Yes	10	5	5
92	S:S:F256	S:S:M209	37.064	3.73	Yes	Yes	1	8	8
93	S:S:L127	S:S:N293	26.6903	4.12	Yes	No	0	8	9
94	S:S:N289	S:S:N293	26.2572	8.17	No	No	0	9	9
95	S:S:N289	S:S:W260	25.5	6.78	No	Yes	0	9	8
96	S:S:G90	S:S:V54	10.0791	1.84	Yes	Yes	3	8	7
97	S:S:L136	S:S:Y135	20.8237	3.52	Yes	Yes	1	5	8
98	S:S:L136	S:S:Y144	28.4764	2.34	Yes	Yes	1	5	8
99	S:S:P74	S:S:Y144	26.0793	4.17	Yes	Yes	1	6	8
100	S:S:A73	S:S:P74	28.5069	1.87	No	Yes	0	7	6
101	S:S:A73	S:S:F76	26.8474	8.32	No	No	0	7	9
102	S:S:F71	S:S:F76	21.8275	16.08	Yes	No	6	9	9
103	S:S:F71	S:S:V307	15.1405	2.62	Yes	No	6	9	7
104	S:S:I64	S:S:V307	13.493	3.07	No	No	0	7	7
105	S:S:L136	X:X:?1	11.0316	13.66	Yes	Yes	1	5	0
106	S:S:R152	S:S:Y144	11.3829	3.09	Yes	Yes	1	6	8
107	S:S:L127	S:S:Y297	10.2111	9.38	Yes	No	0	8	9
108	S:S:D133	S:S:L78	11.3458	5.43	No	No	0	9	8
109	S:S:F101	S:S:V100	19.4741	11.8	Yes	No	0	5	4
110	S:S:S105	S:S:V100	11.7069	3.23	Yes	No	0	6	4
111	S:S:F202	S:S:F203	25.3723	2.14	Yes	No	1	7	5
112	S:S:L261	S:S:P262	10.6301	1.64	No	No	0	4	9
113	R:R:N293	R:R:Y297	11.7539	5.81	Yes	No	0	9	9
114	S:S:Q215	W:W:?1	10.0649	9.38	Yes	Yes	1	6	0
115	S:S:L212	S:S:Y135	17.9968	2.34	Yes	Yes	0	5	8
116	S:S:F202	S:S:F256	23.4215	3.22	Yes	Yes	1	7	8
117	R:R:F256	R:R:M209	14.3004	7.46	Yes	No	2	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Q211	R:R:Q215	7.68	0	Yes	Yes	3	6	1	2
R:R:Q211	S:S:Q211	7.68	0	Yes	Yes	3	3	1	2
R:R:Q211	S:S:L212	5.32	0	Yes	Yes	3	5	1	2
R:R:Q211	X:X:?1	11.26	0	Yes	Yes	3	0	1	0
R:R:A214	X:X:?1	2.22	0	No	Yes	2	0	1	0
R:R:Q215	S:S:Y135	5.64	1	Yes	Yes	6	8	2	2
R:R:R218	S:S:R152	4.26	1	No	Yes	4	6	1	1
R:R:R218	X:X:?1	15.42	1	No	Yes	4	0	1	0
S:S:L128	S:S:V132	2.98	1	Yes	Yes	7	6	1	1
S:S:I208	S:S:L128	4.28	1	No	Yes	6	7	1	1
S:S:L128	S:S:M209	2.83	1	Yes	Yes	7	8	1	2
S:S:L128	X:X:?1	5.86	1	Yes	Yes	7	0	1	0
S:S:A129	S:S:M156	4.83	0	No	Yes	7	6	2	1
S:S:M156	S:S:V132	3.04	1	Yes	Yes	6	6	1	1
S:S:L212	S:S:V132	2.98	0	Yes	Yes	5	6	2	1
S:S:V132	X:X:?1	14.71	1	Yes	Yes	6	0	1	0
S:S:L136	S:S:Y135	3.52	1	Yes	Yes	5	8	1	2
S:S:L212	S:S:Y135	2.34	0	Yes	Yes	5	8	2	2
S:S:L136	S:S:Y144	2.34	1	Yes	Yes	5	8	1	2
S:S:L136	S:S:R152	12.15	1	Yes	Yes	5	6	1	1
S:S:L136	X:X:?1	13.66	1	Yes	Yes	5	0	1	0
S:S:R152	S:S:Y144	3.09	1	Yes	Yes	6	8	1	2
S:S:M156	S:S:R152	3.72	1	Yes	Yes	6	6	1	1
S:S:R152	X:X:?1	3.43	1	Yes	Yes	6	0	1	0
S:S:L159	S:S:V155	2.98	1	No	No	4	4	1	1
S:S:V155	X:X:?1	4.2	1	No	Yes	4	0	1	0
S:S:M156	X:X:?1	7.97	1	Yes	Yes	6	0	1	0
S:S:L159	X:X:?1	1.95	1	No	Yes	4	0	1	0
S:S:I208	X:X:?1	14.09	1	No	Yes	6	0	1	0
R:R:G207	S:S:I208	1.76	0	No	No	4	6	2	1
S:S:L128	S:S:V205	1.49	1	Yes	No	7	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L128	R:R:V132	2.98	1	No	Yes	7	6	1	1
R:R:L128	R:R:V205	7.45	1	No	No	7	7	1	2
R:R:L128	W:W:?1	3.9	1	No	Yes	7	0	1	0
R:R:A129	R:R:M156	3.22	0	No	No	7	6	2	1
R:R:M156	R:R:V132	3.04	1	No	Yes	6	6	1	1
R:R:L212	R:R:V132	2.98	0	Yes	Yes	5	6	2	1
R:R:V132	W:W:?1	8.4	1	Yes	Yes	6	0	1	0
R:R:L212	R:R:Y135	3.52	0	Yes	Yes	5	8	2	2
R:R:Q215	R:R:Y135	15.78	1	Yes	Yes	6	8	2	2
R:R:Y135	S:S:Q215	3.38	1	Yes	Yes	8	6	2	1
R:R:L136	R:R:R152	9.72	1	No	No	5	6	1	2
R:R:L136	S:S:R218	2.43	1	No	No	5	4	1	1
R:R:L136	W:W:?1	9.76	1	No	Yes	5	0	1	0
R:R:L159	R:R:V155	2.98	0	No	No	4	4	1	2
R:R:M156	W:W:?1	3.99	1	No	Yes	6	0	1	0
R:R:L159	W:W:?1	1.95	0	No	Yes	4	0	1	0
R:R:I208	S:S:L210	4.28	1	Yes	No	6	4	1	2
R:R:I208	S:S:Q211	8.23	1	Yes	Yes	6	3	1	1
R:R:I208	W:W:?1	4.03	1	Yes	Yes	6	0	1	0
R:R:Q211	R:R:Q215	7.68	0	Yes	Yes	3	6	2	2
R:R:Q211	S:S:Q211	7.68	0	Yes	Yes	3	3	2	1
R:R:L212	S:S:Q211	13.31	0	Yes	Yes	5	3	2	1
R:R:Q215	S:S:Y135	5.64	1	Yes	Yes	6	8	2	2
R:R:Q215	S:S:Q215	15.36	1	Yes	Yes	6	6	2	1
S:S:Q215	S:S:Y135	12.4	1	Yes	Yes	6	8	1	2
S:S:Q211	S:S:Q215	2.56	1	Yes	Yes	3	6	1	1
S:S:Q211	W:W:?1	18.77	1	Yes	Yes	3	0	1	0
S:S:Q215	W:W:?1	9.38	1	Yes	Yes	6	0	1	0
S:S:R218	W:W:?1	10.28	1	No	Yes	4	0	1	0
R:R:I208	S:S:G207	1.76	1	Yes	No	6	4	1	2
S:S:C221	S:S:R218	1.39	0	No	No	6	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9M8V_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.79
Number of Linked Nodes	465
Number of Links	519
Number of Hubs	62
Number of Links mediated by Hubs	222
Number of Communities	12
Number of Nodes involved in Communities	86
Number of Links involved in Communities	118

Path Summary
Number Of Nodes in MetaPath	118
Number Of Links MetaPath	117
Number of Shortest Paths	219133
Length Of Smallest Path	3
Average Path Length	20.5328
Length of Longest Path	55
Minimum Path Strength	1.15
Average Path Strength	5.29927
Maximum Path Strength	16.47
Minimum Path Correlation	0.7
Average Path Correlation	0.96099
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.7027
Average % Of Corr. Nodes	45.7257
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.3115
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • bioactive lipid receptor activity • sphingosine-1-phosphate receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • multicellular organismal process • homeostatic process • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of cellular component organization • sexual reproduction • regulation of reproductive process • reproductive process • meiotic cell cycle process • cellular component organization • meiotic nuclear division • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • cell cycle process • regulation of meiotic cell cycle • regulation of cell cycle process • meiotic cell cycle • organelle fission • regulation of organelle organization • regulation of meiotic nuclear division • organelle organization • nuclear division • regulation of nuclear division • cellular anatomical structure • periplasmic space • cell periphery • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • system process • nervous system process • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • cellular response to nitrogen compound • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • serotonin receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_W_
PDB Residues	W:W:?1 W:W:?2 X:X:?1 X:X:?2
Environment Details	Open EMBL-EBI Page
Code	_W_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P46089
Sequence	>9M8V_nogp_Chain_R P L P S P K A W D V V L C I S G T L V S C E N A L V V A I I V G T P A F R A P M F L L V G S L A V A D L L A G L G L V L H F A A V F C I G S A E M S L V L V G V L A M A F T A S I G S L L A I T V D R Y L S L Y N A L T Y Y S E T T V T R T Y V M L A L V W G G A L G L G L L P V L A W N C L D G L T T C G V V Y P L S K N H L V V L A I A F F M V F G I M L Q L Y A Q I C R I V C R H A Q Q I A L Q R R K G I A T L A V V L G A F A A C W L P F T V Y C L L G D A H S P P L Y T Y L T L L P A T Y N S M I N P I I Y A F R N Q D V Q K V L W A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	S
Protein	Receptor
UniProt	P46089
Sequence	>9M8V_nogp_Chain_S P L P S P K A W D V V L C I S G T L V S C E N A L V V A I I V G T P A F R A P M F L L V G S L A V A D L L A G L G L V L H F A A V F C I G S A E M S L V L V G V L A M A F T A S I G S L L A I T V D R Y L S L Y N A L T Y Y S E T T V T R T Y V M L A L V W G G A L G L G L L P V L A W N C L D G L T T C G V V Y P L S K N H L V V L A I A F F M V F G I M L Q L Y A Q I C R I V C R H A G I A T L A V V L G A F A A C W L P F T V Y C L L G D A H S P P L Y T Y L T L L P A T Y N S M I N P I I Y A F R N Q D V Q K V L W A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8H8J	A	Orphan	Orphan	GPR35	Homo sapiens	Lodoxamide	Ca	chim(NtGi1L-G13)/β1/γ2	3.2	2023-02-08	doi.org/10.1038/s41421-022-00499-8
	8H8J (No Gprot)	A	Orphan	Orphan	GPR35	Homo sapiens	Lodoxamide	Ca		3.2	2023-02-08	doi.org/10.1038/s41421-022-00499-8
	8SAI	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine (S12)	-	Gi1/β1/γ2	3.27	2023-10-04	doi.org/10.1073/pnas.2308435120
	8SAI (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine (S12)	-		3.27	2023-10-04	doi.org/10.1073/pnas.2308435120
	8K4N	A	Orphan	Orphan	GPR34	Homo sapiens	PubChem 168719765	-	Gi1/β1/γ2	2.83	2023-10-25	To be published
	8K4N (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	PubChem 168719765	-		2.83	2023-10-25	To be published
	8WRB	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine (UBL)	-	Gi1/β1/γ2	2.91	2023-11-08	doi.org/10.1371/journal.pbio.3002387
	8WRB (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine (UBL)	-		2.91	2023-11-08	doi.org/10.1371/journal.pbio.3002387
	8XBE	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-Lysophosphatidylserine	-	Gi1/β1/γ1	3.4	2024-05-15	doi.org/10.1038/s41467-024-45046-z
	8XBE (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-Lysophosphatidylserine	-		3.4	2024-05-15	doi.org/10.1038/s41467-024-45046-z
	8XBG	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-Lysophosphatidylserine	-	-	3.43	2024-05-15	doi.org/10.1038/s41467-024-45046-z
	9M88	A	Orphan	Orphan	GPR3 ; GPR3	Homo sapiens	Oleic monoethanolamide	AF64394	-	3.1	2025-09-24	doi.org/10.1038/s41467-025-63422-1
	9M8P	A	Orphan	Orphan	GPR3 ; GPR3	Homo sapiens	Oleic monoethanolamide	AF64394	-	3.42	2025-09-24	doi.org/10.1038/s41467-025-63422-1
	9M8V	A	Orphan	Orphan	GPR3 ; GPR3	Homo sapiens	-	AF64394	chim(NtGi1-Gs)/β1/γ2	3.83	2025-09-24	doi.org/10.1038/s41467-025-63422-1
	9M8V (No Gprot)	A	Orphan	Orphan	GPR3 ; GPR3	Homo sapiens	-	AF64394		3.83	2025-09-24	doi.org/10.1038/s41467-025-63422-1
	8XBH	A	Orphan	Orphan	GPR34	Homo sapiens	PubChem 162656636	-	Gi1/β1/γ2	2.83	2023-12-27	doi.org/10.1038/s41467-024-45046-z
	8XBH (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	PubChem 162656636	-		2.83	2023-12-27	doi.org/10.1038/s41467-024-45046-z
	8XBI	A	Orphan	Orphan	GPR34	Homo sapiens	PubChem 162656636	-	-	3.06	2023-12-27	doi.org/10.1038/s41467-024-45046-z
	8WW2	A	Orphan	Orphan	GPR3	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.79	2024-02-14	doi.org/10.1038/s41422-024-00932-5
	8WW2 (No Gprot)	A	Orphan	Orphan	GPR3	Homo sapiens	-	-		2.79	2024-02-14	doi.org/10.1038/s41422-024-00932-5
	8U8F	A	Orphan	Orphan	GPR3	Homo sapiens	Palmitic Acid	-	Gs/β1/γ2	3.49	2024-03-06	doi.org/10.1021/acs.biochem.3c00647
	8U8F (No Gprot)	A	Orphan	Orphan	GPR3	Homo sapiens	Palmitic Acid	-		3.49	2024-03-06	doi.org/10.1021/acs.biochem.3c00647
	8IYX	A	Orphan	Orphan	GPR34	Homo sapiens	YL-365	-	-	3.34	2024-03-20	doi.org/10.1073/pnas.2308435120
	8X2K	A	Orphan	Orphan	GPR3	Homo sapiens	Oleic monoethanolamide	-	chim(NtGi1-Gs)/β1/γ2	3.03	2024-04-03	doi.org/10.1038/s41422-023-00919-8
	8X2K (No Gprot)	A	Orphan	Orphan	GPR3	Homo sapiens	Oleic monoethanolamide	-		3.03	2024-04-03	doi.org/10.1038/s41422-023-00919-8
	8XOF	A	Orphan	Orphan	GPR30	Homo sapiens	Lys05	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.6	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOF (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	Lys05	-		2.6	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOG	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOG (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		2.9	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOH	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOH (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		3.2	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOI	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOI (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		3.2	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOJ	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOJ (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		3.1	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8IZ4	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine (TJR)	-	Gi1/β1/γ2	2.94	2024-04-10	To be published
	8IZ4 (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine (TJR)	-		2.94	2024-04-10	To be published
	9LYB	A	Orphan	Orphan	GPR3	Homo sapiens	-	-	Gs/β1/γ2	3.16	2025-04-09	doi.org/10.1016/j.celrep.2025.115478
	9LYB (No Gprot)	A	Orphan	Orphan	GPR3	Homo sapiens	-	-		3.16	2025-04-09	doi.org/10.1016/j.celrep.2025.115478
	9LYC	A	Orphan	Orphan	GPR3; GPR3	Homo sapiens	-	-	Gs/β1/γ2	3.06	2025-04-09	doi.org/10.1016/j.celrep.2025.115478
	9LYC (No Gprot)	A	Orphan	Orphan	GPR3; GPR3	Homo sapiens	-	-		3.06	2025-04-09	doi.org/10.1016/j.celrep.2025.115478
	9LYD	A	Orphan	Orphan	GPR3; GPR3	Homo sapiens	-	-	-	3.66	2025-04-09	doi.org/10.1016/j.celrep.2025.115478

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