Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7C7Q | C | Aminoacid | GABAB | GABAB1; GABAB2 | Homo sapiens | Baclofen | PubChem 7023848 | - | 3 | 2020-07-01 | 10.1038/s41422-020-0350-5 |
![](/psngpcr/ligands/FN0/FN0_7C7Q_W_W_1.png)
A 2D representation of the interactions of FN0 in 7C7Q colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:I785 | R:R:Y810 | 4.84 | 9 | No | Yes | 6 | 9 | 1 | 1 | R:R:A813 | R:R:I785 | 3.25 | 0 | No | No | 7 | 6 | 2 | 1 | R:R:I785 | W:W:?1 | 2.79 | 9 | No | Yes | 6 | 0 | 1 | 0 | R:R:A788 | R:R:I809 | 3.25 | 0 | No | Yes | 9 | 8 | 1 | 2 | R:R:A788 | W:W:?1 | 3.08 | 0 | No | Yes | 9 | 0 | 1 | 0 | R:R:K792 | R:R:Y789 | 10.75 | 9 | No | No | 9 | 8 | 1 | 1 | R:R:Y789 | W:W:?1 | 24.06 | 9 | No | Yes | 8 | 0 | 1 | 0 | R:R:K792 | W:W:?1 | 9.65 | 9 | No | Yes | 9 | 0 | 1 | 0 | R:R:Y810 | S:S:M694 | 5.99 | 9 | Yes | No | 9 | 6 | 1 | 1 | R:R:Y810 | S:S:Y697 | 2.98 | 9 | Yes | Yes | 9 | 9 | 1 | 2 | R:R:Y810 | S:S:N698 | 8.14 | 9 | Yes | Yes | 9 | 9 | 1 | 2 | R:R:Y810 | W:W:?1 | 9.16 | 9 | Yes | Yes | 9 | 0 | 1 | 0 | S:S:D688 | S:S:Y691 | 5.75 | 0 | No | Yes | 9 | 6 | 2 | 1 | S:S:K690 | S:S:Y691 | 10.75 | 9 | No | Yes | 8 | 6 | 1 | 1 | S:S:K690 | W:W:?1 | 9.65 | 9 | No | Yes | 8 | 0 | 1 | 0 | S:S:P742 | S:S:Y691 | 11.13 | 0 | No | Yes | 9 | 6 | 2 | 1 | S:S:Y691 | W:W:?1 | 6.87 | 9 | Yes | Yes | 6 | 0 | 1 | 0 | S:S:L738 | S:S:M694 | 2.83 | 9 | No | No | 7 | 6 | 1 | 1 | S:S:M694 | W:W:?1 | 15.2 | 9 | No | Yes | 6 | 0 | 1 | 0 | S:S:N698 | S:S:Y697 | 4.65 | 9 | Yes | Yes | 9 | 9 | 2 | 2 | S:S:I734 | S:S:N698 | 2.83 | 9 | No | Yes | 4 | 9 | 2 | 2 | S:S:I734 | S:S:L738 | 7.14 | 9 | No | No | 4 | 7 | 2 | 1 | S:S:L738 | W:W:?1 | 2.7 | 9 | No | Yes | 7 | 0 | 1 | 0 | R:R:M807 | W:W:?1 | 1.38 | 0 | No | Yes | 7 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 8.45 | Average Nodes In Shell | 18.00 | Average Hubs In Shell | 6.00 | Average Links In Shell | 24.00 | Average Links Mediated by Hubs In Shell | 20.00 |
| ![](/psngpcr/ligands/FN0/FN0_7C7Q_W_W_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/FN0/FN0_7C7Q_W_W_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7CA3 | C | Aminoacid | GABAB | GABAB1; GABAB2 | Homo sapiens | - | rac-BHFF | - | 4.5 | 2020-11-11 | 10.1016/j.jmb.2020.09.023 |
![](/psngpcr/ligands/FN0/FN0_7CA3_W_W_902.png)
A 2D representation of the interactions of FN0 in 7CA3 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:I785 | W:W:?902 | 2.79 | 0 | No | Yes | 6 | 0 | 1 | 0 | R:R:A788 | W:W:?902 | 4.62 | 0 | No | Yes | 9 | 0 | 1 | 0 | R:R:K792 | R:R:S793 | 3.06 | 10 | No | No | 9 | 7 | 1 | 2 | R:R:K792 | S:S:Y691 | 3.58 | 10 | No | Yes | 9 | 6 | 1 | 1 | R:R:K792 | W:W:?902 | 9.65 | 10 | No | Yes | 9 | 0 | 1 | 0 | R:R:Y810 | S:S:M694 | 3.59 | 10 | No | No | 9 | 6 | 1 | 1 | R:R:Y810 | S:S:N698 | 5.81 | 10 | No | No | 9 | 9 | 1 | 2 | R:R:Y810 | W:W:?902 | 8.02 | 10 | No | Yes | 9 | 0 | 1 | 0 | S:S:D688 | S:S:Y691 | 12.64 | 0 | No | Yes | 9 | 6 | 2 | 1 | S:S:K690 | W:W:?902 | 4.13 | 0 | No | Yes | 8 | 0 | 1 | 0 | S:S:P742 | S:S:Y691 | 11.13 | 10 | No | Yes | 9 | 6 | 2 | 1 | S:S:Y691 | W:W:?902 | 12.6 | 10 | Yes | Yes | 6 | 0 | 1 | 0 | S:S:M694 | W:W:?902 | 13.81 | 10 | No | Yes | 6 | 0 | 1 | 0 | S:S:L738 | W:W:?902 | 2.7 | 0 | No | Yes | 7 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 7.29 | Average Nodes In Shell | 13.00 | Average Hubs In Shell | 2.00 | Average Links In Shell | 14.00 | Average Links Mediated by Hubs In Shell | 11.00 |
| ![](/psngpcr/ligands/FN0/FN0_7CA3_W_W_902_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/FN0/FN0_7CA3_W_W_902_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7EB2 | C | Aminoacid | GABAB | GABAB1; GABAB2 | Homo sapiens | Baclofen | rac-BHFF | Gi1/Beta1/Gamma2 | 3.5 | 2021-05-05 | 10.1038/s41586-021-03507-1 |
![](/psngpcr/ligands/FN0/FN0_7EB2_W_W_901.png)
A 2D representation of the interactions of FN0 in 7EB2 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:I785 | R:R:Y810 | 3.63 | 0 | No | Yes | 6 | 9 | 2 | 1 | R:R:K792 | R:R:Y789 | 7.17 | 21 | No | No | 9 | 8 | 1 | 1 | R:R:Y789 | W:W:?901 | 12.6 | 21 | No | Yes | 8 | 0 | 1 | 0 | R:R:K792 | W:W:?901 | 12.4 | 21 | No | Yes | 9 | 0 | 1 | 0 | R:R:V814 | R:R:Y810 | 8.83 | 0 | No | Yes | 6 | 9 | 2 | 1 | R:R:Y810 | S:S:M694 | 7.18 | 21 | Yes | No | 9 | 6 | 1 | 1 | R:R:Y810 | S:S:Y697 | 2.98 | 21 | Yes | No | 9 | 9 | 1 | 2 | R:R:Y810 | S:S:N698 | 8.14 | 21 | Yes | No | 9 | 9 | 1 | 2 | R:R:Y810 | W:W:?901 | 6.87 | 21 | Yes | Yes | 9 | 0 | 1 | 0 | S:S:K690 | W:W:?901 | 17.91 | 0 | No | Yes | 8 | 0 | 1 | 0 | S:S:P742 | S:S:Y691 | 8.34 | 0 | No | No | 9 | 6 | 2 | 1 | S:S:Y691 | W:W:?901 | 8.02 | 0 | No | Yes | 6 | 0 | 1 | 0 | S:S:M694 | S:S:N698 | 5.61 | 21 | No | No | 6 | 9 | 1 | 2 | S:S:M694 | W:W:?901 | 6.91 | 21 | No | Yes | 6 | 0 | 1 | 0 | S:S:N698 | S:S:Y697 | 3.49 | 21 | No | No | 9 | 9 | 2 | 2 | R:R:M807 | W:W:?901 | 2.76 | 0 | No | Yes | 7 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 7.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 9.64 | Average Nodes In Shell | 13.00 | Average Hubs In Shell | 2.00 | Average Links In Shell | 16.00 | Average Links Mediated by Hubs In Shell | 12.00 |
| ![](/psngpcr/ligands/FN0/FN0_7EB2_W_W_901_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/FN0/FN0_7EB2_W_W_901_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|