Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L38 5.2325488
2A:A:L39 4.1225419
3A:A:K46 4.828589
4A:A:M53 6.3525408
5A:A:I184 4.74419
6A:A:F189 5.218509
7A:A:F191 7.39495
8A:A:F196 5.77697
9A:A:K197 6.925416
10A:A:F199 6.492515
11A:A:E207 4.14419
12A:A:R208 5409
13A:A:W211 4.95667619
14A:A:I212 4.1575418
15A:A:F215 4.55714719
16A:A:I221 4.398518
17A:A:I222 3.145487
18A:A:F223 5.385619
19A:A:Y230 4.422518
20A:A:R242 7.834159
21A:A:M243 2.9375418
22A:A:F250 6.86409
23A:A:I253 4.2175418
24A:A:N256 6.38418
25A:A:W258 7.814515
26A:A:F259 5.83167619
27A:A:I265 2.75167688
28A:A:F267 4.00286789
29A:A:L268 4.6475418
30A:A:N269 5.4425409
31A:A:F274 6.296519
32A:A:C286 4.245416
33A:A:Y287 4.79375817
34A:A:Y290 10.706517
35A:A:Y296 4.078514
36A:A:F307 3.996518
37A:A:Y320 2.795687
38A:A:F323 4.355404
39A:A:N331 6.6425488
40A:A:F334 6.7675483
41A:A:F336 3.854598
42A:A:L348 4.5409
43A:A:L353 4.7507
44A:A:F354 8.462505
45G:G:R27 5.1575458
46G:G:M38 4.014114
47G:G:Y40 6.325466
48G:G:D48 4.054509
49G:G:V54 4.9075436
50G:G:N59 5.912539
51G:G:F61 5.57857738
52R:R:L43 4.545477
53R:R:N54 5.3675429
54R:R:V57 3.87629
55R:R:L67 3.5725408
56R:R:L74 4.2525408
57R:R:L78 3.61529
58R:R:D82 3.98529
59R:R:S86 3.1575408
60R:R:L90 3.318508
61R:R:V98 1.536576
62R:R:W102 5.14857779
63R:R:F112 5.415476
64R:R:T121 3.388508
65R:R:I124 4.18428
66R:R:W125 4.518527
67R:R:H126 7.20286728
68R:R:L127 5.865408
69R:R:I130 4.2325409
70R:R:Y135 8.592509
71R:R:I157 5.3275428
72R:R:T160 4.106528
73R:R:W161 4.90167629
74R:R:F204 8.57167628
75R:R:Y205 6.5825427
76R:R:P207 4.3275429
77R:R:Y215 4.78667629
78R:R:E340 3.0275408
79R:R:F354 4.67529
80R:R:W358 5.33125828
81R:R:L359 5.45407
82R:R:F362 8.3275427
83R:R:P369 3.7175407
84R:R:M377 3.3465144
85R:R:I385 3.3425406
86R:R:W387 5.75578
87R:R:Y390 6.746578
88R:R:N392 7.4125409
89R:R:I399 4.6675408
90R:R:Y400 4.23529
91R:R:Y402 5.224526
92R:R:F407 4.95143728
93R:R:F411 6.7175428
94B:B:R22 5.31456
95B:B:L30 3.6654115
96B:B:T34 3.3654115
97B:B:V40 5.674113
98B:B:M45 4.0775434
99B:B:H54 7.758336109
100B:B:I58 5.054109
101B:B:Y59 9.00833618
102B:B:W63 6.441676107
103B:B:R68 6.835435
104B:B:L69 2.94435
105B:B:V71 3.832538
106B:B:S72 4.835109
107B:B:D76 4.98754109
108B:B:L79 5.0725437
109B:B:I80 8.54254108
110B:B:I81 4.044537
111B:B:W82 7.237147109
112B:B:D83 6.305438
113B:B:K89 5.96409
114B:B:H91 3.5875435
115B:B:I93 7.38407
116B:B:L95 4.84438
117B:B:W99 6.3175819
118B:B:Y105 3.78286736
119B:B:Y111 4.3725124
120B:B:C114 3.4175438
121B:B:L117 4.9575419
122B:B:I123 3.1665126
123B:B:Y124 6.188536
124B:B:L126 3.71435
125B:B:R137 3.22754125
126B:B:H142 6.701676139
127B:B:Y145 4.694518
128B:B:R150 4.0825446
129B:B:F151 4.3365129
130B:B:L152 4.6425443
131B:B:I157 4.63754127
132B:B:C166 3.465448
133B:B:L168 4.3225446
134B:B:W169 9.121676138
135B:B:F180 8.12547
136B:B:H183 7.348549
137B:B:V187 5449
138B:B:M188 3.7975418
139B:B:L190 4.1825445
140B:B:L192 3.806545
141B:B:F199 5.12667649
142B:B:V200 5.6025456
143B:B:S201 4.6075449
144B:B:C204 5.91417
145B:B:K209 6.7725446
146B:B:L210 5.14405
147B:B:W211 8.61667648
148B:B:F222 5.726558
149B:B:H225 6.99759
150B:B:I232 6.0325458
151B:B:F234 5.25405
152B:B:F235 5.34666
153B:B:P236 5.3075467
154B:B:F241 5.23571756
155B:B:T243 5.1025458
156B:B:T249 3.5456
157B:B:R251 8.82167658
158B:B:F253 6.23667656
159B:B:D254 3.7975409
160B:B:D258 9.1675457
161B:B:Y264 5.59565
162B:B:I269 4.652564
163B:B:I273 4.275466
164B:B:F278 4.442567
165B:B:R283 5.3225119
166B:B:L285 3.355466
167B:B:Y289 7.324567
168B:B:V296 3.44405
169B:B:W297 7.45333668
170B:B:D298 7.0154119
171B:B:L300 3.9785116
172B:B:R304 9.44565
173B:B:L308 8.69437
174B:B:H311 6.89409
175B:B:M325 4.432535
176B:B:T329 4.325408
177B:B:W332 9.68167619
178B:B:F335 6.6475404
179B:B:L336 3.534107
180B:B:K337 4.9025436
181B:B:W339 7.18667639
182B:B:N340 5.05739
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L51 B:B:W82 23.6376.83NoYes099
2B:B:L51 B:B:T87 23.6332.95NoNo095
3B:B:R49 B:B:T87 23.65422.59NoNo075
4B:B:R49 G:G:F61 23.70648.55NoYes078
5B:B:N340 G:G:F61 69.61433.62YesYes398
6B:B:M45 B:B:N340 1004.21YesYes349
7B:B:M45 B:B:W339 83.9013.49YesYes349
8B:B:K337 B:B:W339 82.24133.48YesYes369
9B:B:K337 B:B:T50 82.15624.5YesNo063
10B:B:R52 B:B:T50 82.02177.76NoNo073
11B:B:F335 B:B:R52 81.8876.41YesNo047
12B:B:L70 B:B:W82 23.84833.42NoYes1059
13B:B:L70 B:B:W63 23.834610.25NoYes1057
14B:B:S84 B:B:W63 47.08376.18NoYes057
15B:B:S84 G:G:F61 47.10017.93NoYes058
16B:B:W332 B:B:Y59 56.27524.82YesYes198
17B:B:S316 B:B:W332 75.06753.71NoYes099
18B:B:C317 B:B:S316 75.17143.44NoNo079
19B:B:C317 B:B:G330 75.27511.96NoNo075
20B:B:G330 B:B:L336 75.37883.42NoYes057
21B:B:L336 B:B:W82 51.75863.42YesYes1079
22R:R:R148 R:R:Y144 10.44215.14NoNo088
23R:R:D133 R:R:R148 10.80959.53NoNo098
24R:R:D133 R:R:L74 11.17845.43NoYes098
25R:R:I130 R:R:L74 11.73454.28YesYes098
26R:R:I130 R:R:L78 30.13482.85YesYes099
27R:R:D82 R:R:L78 48.24672.71YesYes299
28R:R:D82 R:R:P397 66.86084.83YesNo299
29R:R:P397 R:R:V57 76.11851.77NoYes299
30R:R:F407 R:R:V57 76.72346.55YesYes289
31R:R:F407 R:R:L67 78.75622.44YesYes088
32R:R:A410 R:R:L67 79.30564.73NoYes088
33R:R:A410 R:R:E64 79.44264.53NoNo087
34R:R:E64 R:R:K413 79.98958.1NoNo076
35B:B:D312 R:R:K413 80.12555.53NoNo056
36B:B:D312 B:B:D333 80.2627.98NoNo059
37B:B:D333 B:B:F335 80.398214.33NoYes094
38R:R:I130 R:R:R134 15.85423.76YesNo099
39A:A:C351 R:R:R134 15.67456.96NoNo049
40A:A:C351 A:A:L353 15.50166.35NoYes047
41A:A:L348 A:A:L353 15.92134.15YesYes097
42A:A:F354 A:A:L348 12.52072.44YesYes059
43A:A:H213 B:B:W332 17.93025.29NoYes189
44A:A:H213 A:A:W258 17.92710.58NoYes185
45A:A:I212 A:A:W258 16.46092.35YesYes185
46A:A:F223 A:A:L249 17.48566.09YesNo199
47A:A:L249 A:A:R208 17.81114.86NoYes099
48A:A:I212 A:A:R208 15.53355.01YesYes089
49B:B:M101 B:B:Y59 49.37152.39NoYes098
50B:B:M101 B:B:Y145 44.192.39NoYes098
51A:A:K210 B:B:M188 21.78425.76NoYes098
52B:B:M188 B:B:Y145 22.08673.59YesYes188
53B:B:C204 B:B:D186 22.41654.67YesNo179
54B:B:D186 B:B:Y145 22.56698.05NoYes198
55B:B:C204 B:B:D228 21.337812.45YesNo179
56A:A:K210 B:B:N230 21.31244.2NoNo099
57R:R:L127 R:R:L78 10.24476.92YesYes089
58R:R:D82 R:R:N396 18.64552.69YesNo099
59R:R:L127 R:R:N396 10.06038.24YesNo089
60B:B:H62 B:B:Y105 19.17524.36NoYes066
61B:B:H62 B:B:R150 18.97264.51NoYes066
62B:B:D228 B:B:D246 21.20252.66NoNo099
63B:B:D246 B:B:S227 42.04977.36NoNo096
64B:B:D247 B:B:S227 41.7375.89NoNo096
65B:B:D247 B:B:T249 41.11122.89NoYes096
66B:B:H225 B:B:T249 26.66862.74YesYes596
67B:B:F253 B:B:H225 12.22214.53YesYes569
68B:B:D246 B:B:N230 21.16048.08NoNo099
69B:B:R251 B:B:T249 13.81625.17YesYes586
70B:B:F253 B:B:R251 12.22065.34YesYes568
71B:B:I43 B:B:M45 20.34194.37NoYes034
72B:B:I43 B:B:V40 20.15853.07NoYes033
73B:B:D298 B:B:V40 17.32538.76YesYes1193
74B:B:D298 B:B:L300 16.65645.43YesYes1196
75B:B:A299 B:B:L300 11.12951.58NoYes056
76B:B:A299 B:B:L285 10.94111.58NoYes056
77B:B:L69 B:B:R68 15.28222.43YesYes355
78B:B:R68 B:B:Y85 15.42618.23YesNo354
79B:B:Y85 G:G:P60 31.32484.17NoNo349
80B:B:D83 B:B:L69 15.37522.71YesYes385
81B:B:D83 B:B:Y85 15.87475.75YesNo384
82R:R:F354 R:R:L127 14.94082.44YesYes098
83R:R:F204 R:R:F354 12.71116.43YesYes289
84R:R:F204 R:R:L359 13.87758.53YesYes087
85B:B:M61 B:B:S72 23.47074.6NoYes1069
86B:B:L79 B:B:V71 13.22022.98YesYes378
87B:B:H225 B:B:T243 12.86585.48YesYes598
88B:B:F234 B:B:V200 12.87949.18YesYes056
89B:B:F241 B:B:V200 14.4852.62YesYes566
90B:B:F241 B:B:F253 14.15539.65YesYes566
91G:G:N59 G:G:P60 15.79936.52YesNo399
92B:B:N340 G:G:N59 15.46776.81YesYes399
93B:B:M325 G:G:P60 15.798210.06YesNo359
94B:B:M325 B:B:N340 15.59122.8YesYes359
95B:B:L69 B:B:Y105 22.96982.34YesYes356
96B:B:M61 B:B:W63 23.46765.82NoYes1067
97B:B:L336 B:B:S72 23.28143YesYes1079
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7E2X
Class A
SubFamily Amine
Type 5-Hydroxytryptamine
SubType 5-HT1A
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3
Date 2021-04-14
D.O.I. 10.1038/s41586-021-03376-8
Net Summary
Imin 1.96
Number of Linked Nodes 787
Number of Links 1004
Number of Hubs 182
Number of Links mediated by Hubs 649
Number of Communities 22
Number of Nodes involved in Communities 267
Number of Links involved in Communities 407
Path Summary
Number Of Nodes in MetaPath 98
Number Of Links MetaPath 97
Number of Shortest Paths 2033217
Length Of Smallest Path 3
Average Path Length 34.7263
Length of Longest Path 68
Minimum Path Strength 1.29
Average Path Strength 5.03255
Maximum Path Strength 22.425
Minimum Path Correlation 0.7
Average Path Correlation 0.979435
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2
Average % Of Corr. Nodes 35.8693
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 53.9383
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7E2X_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKNT 
IVKQMKITG IVETHFTFK DLHFKMFDV GAQRSERKK WIHCFEGVT 
AIIFCVALS DYDLVLNRM HASMKLFDS ICNNKWFTD TSIILFLNK 
KDLFEEKIK KSPLTICYP EYAGSNTYE EAAAYIQCQ FEDLNKRKD 
TKEIYTHFT CSTDTKNVQ FVFDAVTDV IIKNNLKDC GLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7E2X_Chain_G
QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP VPASENPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP08908
Sequence
>7E2X_Chain_R
YQVITSLLL GTLIFCAVL GNACVVAAI ALERSLQNV ANYLIGSLA 
VTDLMVSVL VLPMAALYQ VLNKWTLGQ VTCDLFIAL DVLCCTSSI 
WHLCAIALD RYWAITDPI DYVNKRTPR RAAALISLT WLIGFLISI 
PPMLGWPDA CTISKDHGY TIYSTFGAF YIPLLLMLV LYGRIFRAA 
RFRIRKKNE RNAEAKRKM ALARERKTV KTLGIIMGT FILCWLPFF 
IVALVLPFC ESSCHMPTL LGAIINWLG YSNSLLNPV IYAYFNKDF 
QNAFKKII


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7E2X_Chain_B
QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR RTLRGHLAK 
IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI PLRSSWVMT 
CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE LAGHTGYLS 
CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH TGDVMSLSL 
APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD INAICFFPN 
GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI TSVSFSKSG 
RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL GVTDDGMAV 
ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7E2YAAmine5-Hydroxytryptamine5-HT1AHomo sapiensSerotonin-Gi1/&β;1/&γ;232021-04-1410.1038/s41586-021-03376-8
7E2ZAAmine5-Hydroxytryptamine5-HT1AHomo sapiensAripiprazole-Gi1/&β;1/&γ;23.12021-04-1410.1038/s41586-021-03376-8
8JSPAAmine5-Hydroxytryptamine5-HT1AHomo sapiensUlotaront-Gi1/&β;1/&γ;23.652023-11-1510.1038/s41586-023-06804-z
8JT6AAmine5-Hydroxytryptamine5-HT1AHomo sapiens(R)-IHCH-7179-Gi1/&β;1/&γ;232024-02-28To be published
8W8BAAmine5-Hydroxytryptamine5-HT1AHomo sapiensSEP-363856-Gi1/&β;1/&γ;232023-11-2210.1038/s41586-023-06775-1




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7E2X.zip



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