psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D116	17.97	Yes	No	2	0	8
2	L:L:?1	R:R:V117	8.77	Yes	No	0	0	8
3	L:L:?1	R:R:C120	9.34	Yes	No	0	0	7
4	L:L:?1	R:R:T121	5.42	Yes	No	0	0	8
5	L:L:?1	R:R:I124	4.2	Yes	Yes	2	0	8
6	L:L:?1	R:R:I189	4.2	Yes	Yes	0	0	6
7	L:L:?1	R:R:S199	6.63	Yes	No	0	0	8
8	L:L:?1	R:R:A203	3.48	Yes	No	0	0	8
9	L:L:?1	R:R:W358	10.89	Yes	Yes	2	0	8
10	L:L:?1	R:R:F361	8.96	Yes	Yes	2	0	8
11	L:L:?1	R:R:F362	12.54	Yes	Yes	2	0	7
12	L:L:?1	R:R:Y390	3.45	Yes	Yes	2	0	8
13	R:R:Q36	R:R:T39	9.92	No	No	4	4	5
14	R:R:Q36	R:R:V98	5.73	No	Yes	4	4	6
15	R:R:T39	R:R:V98	4.76	No	Yes	4	5	6
16	R:R:A94	R:R:L43	3.15	No	No	0	7	7
17	R:R:L43	R:R:W387	11.39	No	Yes	0	7	8
18	R:R:I47	R:R:L90	4.28	No	Yes	0	7	8
19	R:R:C49	R:R:L394	3.17	No	No	0	5	7
20	R:R:A50	R:R:S86	3.42	No	No	0	8	8
21	R:R:G53	R:R:Y402	4.35	No	Yes	0	9	6
22	R:R:D82	R:R:N54	5.39	Yes	No	0	9	9
23	R:R:N54	R:R:P397	6.52	No	No	0	9	9
24	R:R:A79	R:R:V57	3.39	No	No	0	9	9
25	R:R:A401	R:R:V57	3.39	No	No	0	8	9
26	R:R:V57	R:R:Y402	5.05	No	Yes	0	9	6
27	R:R:V58	R:R:V80	3.21	No	No	0	7	7
28	R:R:A60	R:R:F411	4.16	No	Yes	0	8	8
29	R:R:F407	R:R:I61	5.02	Yes	No	0	8	8
30	R:R:E64	R:R:K413	13.5	No	No	0	7	6
31	R:R:Q68	R:R:R65	5.84	No	No	0	8	7
32	R:R:L67	R:R:N72	4.12	Yes	Yes	1	8	9
33	R:R:D406	R:R:L67	4.07	Yes	Yes	1	7	8
34	R:R:F407	R:R:L67	6.09	Yes	Yes	1	8	8
35	R:R:A410	R:R:L67	3.15	No	Yes	0	8	8
36	R:R:Q68	R:R:Y73	3.38	No	No	0	8	6
37	R:R:N69	R:R:N72	12.26	No	Yes	1	8	9
38	R:R:R148	R:R:V70	15.69	Yes	No	0	8	7
39	R:R:P150	R:R:V70	3.53	No	No	0	5	7
40	R:R:D406	R:R:N72	5.39	Yes	Yes	1	7	9
41	R:R:F407	R:R:N72	6.04	Yes	Yes	1	8	9
42	R:R:D133	R:R:L74	4.07	No	No	0	9	8
43	R:R:L156	R:R:L74	4.15	No	No	7	6	8
44	R:R:H126	R:R:S77	6.97	Yes	No	3	8	9
45	R:R:I157	R:R:S77	10.84	No	No	3	8	9
46	R:R:D82	R:R:L78	5.43	Yes	No	1	9	9
47	R:R:L78	R:R:N396	6.87	No	Yes	1	9	9
48	R:R:L78	R:R:Y400	3.52	No	Yes	1	9	9
49	R:R:S122	R:R:T81	6.4	Yes	No	3	8	9
50	R:R:H126	R:R:T81	8.21	Yes	No	3	8	9
51	R:R:T81	R:R:W161	8.49	No	Yes	3	9	9
52	R:R:D82	R:R:S123	5.89	Yes	No	0	9	9
53	R:R:D82	R:R:S393	4.42	Yes	No	0	9	9
54	R:R:D82	R:R:N396	6.73	Yes	Yes	1	9	9
55	R:R:C119	R:R:M84	3.24	No	No	0	7	7
56	R:R:M84	R:R:W161	3.49	No	Yes	0	7	9
57	R:R:C120	R:R:V85	3.42	No	No	0	7	8
58	R:R:D116	R:R:V89	4.38	No	No	2	8	8
59	R:R:V89	R:R:Y390	3.79	No	Yes	2	8	8
60	R:R:L90	R:R:Y390	5.86	Yes	Yes	0	8	8
61	R:R:F112	R:R:M92	6.22	No	No	0	6	6
62	R:R:L95	R:R:L99	4.15	No	No	4	6	5
63	R:R:W102	R:R:Y96	9.65	Yes	No	0	9	6
64	R:R:A383	R:R:Q97	4.55	No	No	0	6	7
65	R:R:Q97	R:R:W387	5.48	No	Yes	0	7	8
66	R:R:L104	R:R:W102	7.97	No	Yes	0	7	9
67	R:R:C109	R:R:W102	6.53	Yes	Yes	5	9	9
68	R:R:F112	R:R:W102	7.02	No	Yes	0	6	9
69	R:R:C187	R:R:W102	16.98	No	Yes	5	9	9
70	R:R:L104	R:R:T108	7.37	No	No	0	7	6
71	R:R:C109	R:R:I113	3.27	Yes	No	5	9	7
72	R:R:C109	R:R:C187	7.28	Yes	No	5	9	9
73	R:R:D110	R:R:R181	4.76	No	No	0	7	4
74	R:R:C187	R:R:I113	3.27	No	No	5	9	7
75	R:R:D116	R:R:Y390	9.2	No	Yes	2	8	8
76	R:R:S168	R:R:V117	4.85	No	No	0	8	8
77	R:R:L118	R:R:W161	5.69	No	Yes	0	6	9
78	R:R:F165	R:R:L118	9.74	No	No	0	5	6
79	R:R:G164	R:R:T121	3.64	No	No	0	8	8
80	R:R:I167	R:R:T121	4.56	No	No	0	8	8
81	R:R:H126	R:R:S122	4.18	Yes	Yes	3	8	8
82	R:R:S122	R:R:T160	3.2	Yes	No	3	8	8
83	R:R:S122	R:R:W161	18.53	Yes	Yes	3	8	9
84	R:R:I124	R:R:P207	3.39	Yes	No	0	8	9
85	R:R:F354	R:R:I124	7.54	Yes	Yes	0	9	8
86	R:R:I124	R:R:W358	8.22	Yes	Yes	2	8	8
87	R:R:I163	R:R:W125	12.92	No	No	0	5	7
88	R:R:P207	R:R:W125	14.86	No	No	0	9	7
89	R:R:H126	R:R:I157	3.98	Yes	No	3	8	8
90	R:R:H126	R:R:T160	17.8	Yes	No	3	8	8
91	R:R:L127	R:R:N396	5.49	No	Yes	0	8	9
92	R:R:L127	R:R:Y400	5.86	No	Yes	0	8	9
93	R:R:C128	R:R:L210	3.17	No	No	0	7	7
94	R:R:C128	R:R:M211	4.86	No	Yes	0	7	9
95	R:R:I130	R:R:R134	6.26	No	Yes	1	9	9
96	R:R:I130	R:R:Y400	8.46	No	Yes	1	9	9
97	R:R:A131	R:R:Y215	6.67	No	Yes	0	9	9
98	R:R:L132	R:R:W136	11.39	No	No	0	6	5
99	R:R:L132	R:R:L214	4.15	No	No	0	6	7
100	R:R:D133	R:R:R148	10.72	No	Yes	0	9	8
101	R:R:R134	R:R:Y215	7.2	Yes	Yes	1	9	9
102	R:R:R134	R:R:Y400	6.17	Yes	Yes	1	9	9
103	R:R:R134	W:W:?1	3.25	Yes	Yes	1	9	0
104	R:R:T139	R:R:Y135	12.48	No	Yes	0	8	9
105	R:R:L214	R:R:Y135	4.69	No	Yes	0	7	9
106	R:R:R217	R:R:Y135	12.35	No	Yes	0	7	9
107	R:R:I218	R:R:Y135	3.63	No	Yes	0	9	9
108	R:R:R152	R:R:W136	7	No	No	0	7	5
109	R:R:D140	R:R:T139	4.34	No	No	0	7	8
110	R:R:D143	R:R:K147	4.15	No	No	0	6	5
111	R:R:D143	R:R:R152	10.72	No	No	0	6	7
112	R:R:R148	R:R:Y144	11.32	Yes	No	0	8	8
113	R:R:N146	R:R:V145	4.43	No	No	0	5	6
114	R:R:R148	R:R:R152	4.26	Yes	No	0	8	7
115	R:R:T160	R:R:W161	4.85	No	Yes	3	8	9
116	R:R:I167	R:R:Y198	6.04	No	No	0	8	5
117	R:R:I169	R:R:P170	3.39	No	No	0	6	8
118	R:R:P170	R:R:P171	5.84	No	No	0	8	7
119	R:R:P171	R:R:Y195	12.52	No	Yes	0	7	8
120	R:R:D192	R:R:W175	3.35	No	No	0	6	6
121	R:R:D180	R:R:R176	8.34	No	No	0	4	6
122	R:R:R176	R:R:R181	10.66	No	No	0	6	4
123	R:R:R176	R:R:S190	3.95	No	No	0	6	6
124	R:R:E179	R:R:T177	4.23	No	No	0	3	5
125	R:R:D180	R:R:T188	5.78	No	No	0	4	5
126	R:R:D183	R:R:P184	6.44	No	No	0	1	1
127	R:R:D183	R:R:D185	11.98	No	No	0	1	4
128	R:R:A186	R:R:D183	4.63	No	No	0	4	1
129	R:R:I189	R:R:K191	4.36	Yes	No	0	6	5
130	R:R:I189	R:R:Y195	3.63	Yes	Yes	0	6	8
131	R:R:D192	R:R:G194	5.03	No	No	0	6	5
132	R:R:F370	R:R:H193	28.28	No	No	0	5	4
133	R:R:E372	R:R:H193	6.15	No	No	0	3	4
134	R:R:S199	R:R:Y195	15.26	No	Yes	0	8	8
135	R:R:P369	R:R:T196	8.74	No	No	0	7	7
136	R:R:F370	R:R:T196	3.89	No	No	0	5	7
137	R:R:F201	R:R:I197	3.77	No	No	0	5	7
138	R:R:F370	R:R:I197	5.02	No	No	0	5	7
139	R:R:T200	R:R:Y205	6.24	No	Yes	6	7	7
140	R:R:L366	R:R:T200	5.9	No	No	6	7	7
141	R:R:F201	R:R:Y205	14.44	No	Yes	6	5	7
142	R:R:F201	R:R:L366	3.65	No	No	6	5	7
143	R:R:F204	R:R:Y205	5.16	Yes	Yes	0	8	7
144	R:R:F204	R:R:F354	5.36	Yes	Yes	0	8	9
145	R:R:F204	R:R:L359	6.09	Yes	Yes	0	8	7
146	R:R:F204	R:R:F362	19.29	Yes	Yes	0	8	7
147	R:R:L366	R:R:Y205	8.21	No	Yes	6	7	7
148	R:R:I206	R:R:P207	3.39	No	No	0	6	9
149	R:R:L208	R:R:L212	4.15	No	No	0	7	6
150	R:R:F354	R:R:L208	3.65	Yes	No	0	9	7
151	R:R:L210	R:R:L214	5.54	No	No	0	7	7
152	R:R:M211	R:R:Y215	3.59	Yes	Yes	1	9	9
153	R:R:M211	R:R:M351	4.33	Yes	No	1	9	8
154	R:R:F354	R:R:M211	3.73	Yes	Yes	0	9	9
155	R:R:R217	R:R:V213	5.23	No	No	0	7	5
156	R:R:L347	R:R:Y215	4.69	No	Yes	0	8	9
157	R:R:I350	R:R:Y215	7.25	No	Yes	0	8	9
158	R:R:M351	R:R:Y215	3.59	No	Yes	1	8	9
159	R:R:F219	R:R:R223	9.62	Yes	No	0	6	7
160	R:R:F219	R:R:T343	7.78	Yes	No	0	6	8
161	R:R:F219	R:R:L347	3.65	Yes	No	0	6	8
162	R:R:R223	R:R:R227	12.79	No	No	0	7	6
163	R:R:E340	R:R:R223	8.14	No	No	0	8	7
164	R:R:F224	R:R:K228	4.96	No	No	0	6	5
165	R:R:K228	R:R:R225	4.95	No	No	0	5	7
166	R:R:I226	R:R:R339	3.76	No	No	0	6	7
167	R:R:N325	R:R:N328	4.09	No	No	0	5	3
168	R:R:E326	R:R:R327	6.98	No	No	0	3	3
169	R:R:A329	R:R:E326	4.53	No	No	0	5	3
170	R:R:E330	R:R:R333	5.82	No	No	0	4	4
171	R:R:M335	R:R:R339	6.2	No	No	0	4	7
172	R:R:I349	R:R:K345	4.36	No	No	1	7	7
173	R:R:K345	W:W:?1	3.78	No	Yes	1	7	0
174	R:R:T346	W:W:?1	10.85	No	Yes	0	8	0
175	R:R:I349	R:R:I399	4.42	No	No	0	7	8
176	R:R:I349	W:W:?1	5.73	No	Yes	1	7	0
177	R:R:I355	R:R:L359	4.28	No	Yes	0	7	7
178	R:R:C357	R:R:N392	6.3	No	No	0	8	9
179	R:R:F361	R:R:W358	5.01	Yes	Yes	2	8	8
180	R:R:F362	R:R:W358	6.01	Yes	Yes	2	7	8
181	R:R:G389	R:R:W358	8.44	No	Yes	0	8	8
182	R:R:N392	R:R:W358	6.78	No	Yes	0	9	8
183	R:R:L359	R:R:P360	3.28	Yes	No	0	7	9
184	R:R:I363	R:R:L359	5.71	No	Yes	0	7	7
185	R:R:F361	R:R:F362	11.79	Yes	Yes	2	8	7
186	R:R:F361	R:R:N386	4.83	Yes	No	0	8	7
187	R:R:M377	R:R:V364	7.61	No	No	0	4	6
188	R:R:I385	R:R:V364	4.61	No	No	0	6	6
189	R:R:L368	R:R:P369	3.28	No	No	0	4	7
190	R:R:S373	R:R:S374	3.26	No	No	0	3	5
191	R:R:L381	R:R:P378	6.57	No	No	0	6	7
192	R:R:I384	R:R:L380	5.71	No	No	0	4	3
193	R:R:G382	R:R:I385	3.53	No	No	0	4	6
194	R:R:W387	R:R:Y390	8.68	Yes	Yes	0	8	8
195	R:R:N392	R:R:N396	12.26	No	Yes	0	9	9
196	R:R:F403	R:R:V398	5.24	No	No	0	8	6
197	R:R:A401	R:R:F407	8.32	No	Yes	0	8	8
198	R:R:F411	R:R:Y402	6.19	Yes	Yes	0	8	6
199	R:R:Y402	W:W:?1	6.28	Yes	Yes	0	6	0
200	R:R:F403	W:W:?1	30.17	No	Yes	0	8	0
201	R:R:D406	R:R:N404	13.46	Yes	No	1	7	9
202	R:R:F407	R:R:N404	12.08	Yes	No	1	8	9
203	R:R:N404	W:W:?1	4.6	No	Yes	1	9	0
204	R:R:K405	R:R:Q408	4.07	No	No	0	6	9
205	R:R:D406	R:R:F407	4.78	Yes	Yes	1	7	8
206	R:R:F407	R:R:F411	5.36	Yes	Yes	0	8	8
207	R:R:E179	R:R:P178	3.14	No	No	0	3	5
208	R:R:C109	R:R:D110	3.11	Yes	No	0	9	7
209	R:R:I226	R:R:T343	3.04	No	No	0	6	8
210	R:R:I399	R:R:T353	3.04	No	No	0	8	7
211	R:R:A410	R:R:E64	3.02	No	No	0	8	7
212	R:R:L67	R:R:S66	3	Yes	No	0	8	6
213	R:R:L90	R:R:S86	3	Yes	No	0	8	8
214	R:R:K101	R:R:T103	3	No	No	0	5	5
215	R:R:L118	R:R:S168	3	No	No	0	6	8
216	R:R:L41	R:R:V37	2.98	No	No	0	4	5
217	R:R:L83	R:R:V51	2.98	No	No	0	8	7
218	R:R:L99	R:R:V98	2.98	No	Yes	4	5	6
219	R:R:L395	R:R:T353	2.95	No	No	0	6	7
220	R:R:I113	R:R:I189	2.94	No	Yes	0	7	6
221	R:R:L88	R:R:M84	2.83	No	No	0	6	7
222	R:R:I385	R:R:N386	2.83	No	No	0	6	7
223	R:R:G174	R:R:W175	2.81	No	No	0	5	6
224	R:R:C56	R:R:F411	2.79	No	Yes	0	8	8
225	R:R:A93	R:R:F112	2.77	No	No	0	7	6
226	R:R:L104	R:R:L95	2.77	No	No	0	7	6
227	R:R:L111	R:R:L115	2.77	No	No	0	5	5
228	R:R:A365	R:R:F361	2.77	No	Yes	0	8	8
229	R:R:L83	R:R:N54	2.75	No	No	0	8	9
230	R:R:A137	R:R:Y144	2.67	No	No	0	8	8
231	R:R:F219	R:R:V344	2.62	Yes	No	0	6	8
232	R:R:R151	R:R:T149	2.59	No	No	0	6	8
233	R:R:E326	R:R:E330	2.54	No	No	0	3	4
234	R:R:F48	R:R:L52	2.44	No	No	0	4	4
235	R:R:D192	R:R:Y195	2.3	No	Yes	0	6	8
236	R:R:L46	R:R:W387	2.28	No	Yes	0	7	8
237	R:R:A79	R:R:G76	1.95	No	No	0	9	6
238	R:R:C371	R:R:C375	1.82	No	No	0	5	4
239	R:R:G202	R:R:I206	1.76	No	No	0	5	6
240	R:R:P150	R:R:T149	1.75	No	No	0	5	8
241	R:R:G352	R:R:M351	1.75	No	No	0	6	8
242	R:R:C357	R:R:S391	1.72	No	No	0	8	5
243	R:R:G53	R:R:L52	1.71	No	No	0	9	4
244	R:R:A114	R:R:S168	1.71	No	No	0	7	8
245	R:R:C371	R:R:V367	1.71	No	No	0	5	6
246	R:R:G382	R:R:L381	1.71	No	No	0	4	6
247	R:R:A79	R:R:V58	1.7	No	No	0	9	7
248	R:R:A153	R:R:V70	1.7	No	No	0	7	7
249	R:R:C49	R:R:T45	1.69	No	No	0	5	4
250	R:R:I142	R:R:P141	1.69	No	No	0	6	8
251	R:R:A186	R:R:T188	1.68	No	No	0	4	5
252	R:R:A222	R:R:T343	1.68	No	No	0	8	8
253	R:R:L90	R:R:P91	1.64	Yes	No	0	8	9
254	R:R:L388	R:R:P360	1.64	No	No	0	8	9
255	R:R:S40	R:R:V98	1.62	No	Yes	0	5	6
256	R:R:A60	R:R:I414	1.62	No	No	0	8	7
257	R:R:A401	R:R:I75	1.62	No	No	0	8	8
258	R:R:A221	R:R:I138	1.62	No	No	0	6	9
259	R:R:A336	R:R:I226	1.62	No	No	0	5	6
260	R:R:A114	R:R:M172	1.61	No	No	0	7	6
261	R:R:D140	R:R:P141	1.61	No	No	0	7	8
262	R:R:V51	R:R:V87	1.6	No	No	0	7	6
263	R:R:C119	R:R:L115	1.59	No	No	0	7	5
264	R:R:C375	R:R:L368	1.59	No	No	0	4	4
265	R:R:A50	R:R:L394	1.58	No	No	0	8	7
266	R:R:A55	R:R:L83	1.58	No	No	0	5	8
267	R:R:A129	R:R:L74	1.58	No	No	7	8	8
268	R:R:P184	R:R:Q106	1.58	No	No	0	1	4
269	R:R:A129	R:R:L156	1.58	No	No	7	8	6
270	R:R:A71	R:R:N69	1.56	No	No	1	8	8
271	R:R:A71	R:R:N72	1.56	No	Yes	1	8	9
272	R:R:L159	R:R:S158	1.5	No	No	0	3	5
273	R:R:K342	R:R:T346	1.5	No	No	0	8	8
274	R:R:L95	R:R:T103	1.47	No	No	4	6	5
275	R:R:L99	R:R:T103	1.47	No	No	4	5	5
276	R:R:I138	R:R:I218	1.47	No	No	0	9	9
277	R:R:I414	R:R:I415	1.47	No	No	0	7	7
278	R:R:D180	R:R:T177	1.45	No	No	0	4	5
279	R:R:I38	R:R:L42	1.43	No	No	0	3	5
280	R:R:I414	R:R:L63	1.43	No	No	0	7	6
281	R:R:I142	R:R:N146	1.42	No	No	0	6	5
282	R:R:G105	R:R:W102	1.41	No	Yes	0	7	9
283	R:R:K324	R:R:N325	1.4	No	No	0	1	5
284	R:R:P150	R:R:Y73	1.39	No	No	0	5	6
285	R:R:L159	R:R:L162	1.38	No	No	0	3	5
286	R:R:L162	R:R:L166	1.38	No	No	0	5	5
287	R:R:E330	R:R:K334	1.35	No	No	0	4	5
288	R:R:N409	R:R:Q408	1.32	No	No	0	6	9
289	R:R:I38	R:R:Y35	1.21	No	No	0	3	4
290	R:R:L166	R:R:Y198	1.17	No	No	0	5	5
291	R:R:Q36	R:R:Y35	1.13	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.9875	12	2	0
2	R:R:L67	4.086	5	1	8
3	R:R:N72	5.874	5	1	9
4	R:R:D82	5.572	5	1	9
5	R:R:L90	3.695	4	0	8
6	R:R:V98	3.7725	4	4	6
7	R:R:W102	8.26	6	5	9
8	R:R:C109	5.0475	4	5	9
9	R:R:S122	8.0775	4	3	8
10	R:R:I124	5.8375	4	2	8
11	R:R:H126	8.228	5	3	8
12	R:R:R134	5.72	4	1	9
13	R:R:Y135	8.2875	4	0	9
14	R:R:R148	10.4975	4	0	8
15	R:R:W161	8.21	5	3	9
16	R:R:I189	3.7825	4	0	6
17	R:R:Y195	8.4275	4	0	8
18	R:R:F204	8.975	4	0	8
19	R:R:Y205	8.5125	4	6	7
20	R:R:M211	4.1275	4	1	9
21	R:R:Y215	5.49833	6	1	9
22	R:R:F219	5.9175	4	0	6
23	R:R:F354	5.07	4	0	9
24	R:R:W358	7.55833	6	2	8
25	R:R:L359	4.84	4	0	7
26	R:R:F361	6.672	5	2	8
27	R:R:F362	12.4075	4	2	7
28	R:R:W387	6.9575	4	0	8
29	R:R:Y390	6.196	5	2	8
30	R:R:N396	7.8375	4	1	9
31	R:R:Y400	6.0025	4	1	9
32	R:R:Y402	5.4675	4	0	6
33	R:R:D406	6.925	4	1	7
34	R:R:F407	6.81286	7	1	8
35	R:R:F411	4.625	4	0	8
36	W:W:?1	9.23714	7	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:I189	72.2651	4.2	Yes	Yes	0	0	6
2	R:R:I113	R:R:I189	64.3789	2.94	No	Yes	0	7	6
3	R:R:C109	R:R:I113	40.0655	3.27	Yes	No	5	9	7
4	R:R:C109	R:R:W102	23.802	6.53	Yes	Yes	5	9	9
5	R:R:L104	R:R:W102	32.1741	7.97	No	Yes	0	7	9
6	R:R:L104	R:R:L95	27.336	2.77	No	No	0	7	6
7	R:R:L95	R:R:L99	19.9202	4.15	No	No	4	6	5
8	R:R:L99	R:R:V98	17.5369	2.98	No	Yes	4	5	6
9	R:R:Q36	R:R:V98	10.0598	5.73	No	Yes	4	4	6
10	R:R:C187	R:R:I113	23.5207	3.27	No	No	5	9	7
11	R:R:C187	R:R:W102	22.4365	16.98	No	Yes	5	9	9
12	L:L:?1	R:R:Y390	21.9608	3.45	Yes	Yes	2	0	8
13	R:R:L90	R:R:Y390	11.4663	5.86	Yes	Yes	0	8	8
14	L:L:?1	R:R:I124	78.6222	4.2	Yes	Yes	2	0	8
15	R:R:F354	R:R:I124	85.5777	7.54	Yes	Yes	0	9	8
16	R:R:F354	R:R:M211	100	3.73	Yes	Yes	0	9	9
17	R:R:M211	R:R:Y215	77.6709	3.59	Yes	Yes	1	9	9
18	R:R:R134	R:R:Y215	66.7059	7.2	Yes	Yes	1	9	9
19	R:R:R134	W:W:?1	70.9763	3.25	Yes	Yes	1	9	0
20	R:R:Y402	W:W:?1	25.6227	6.28	Yes	Yes	0	6	0
21	L:L:?1	R:R:W358	13.6961	10.89	Yes	Yes	2	0	8
22	R:R:N392	R:R:W358	22.5081	6.78	No	Yes	0	9	8
23	R:R:N392	R:R:N396	21.342	12.26	No	Yes	0	9	9
24	R:R:V57	R:R:Y402	10.8423	5.05	No	Yes	0	9	6
25	R:R:N404	W:W:?1	33.1407	4.6	No	Yes	1	9	0
26	R:R:F407	R:R:N404	18.1558	12.08	Yes	No	1	8	9
27	R:R:D406	R:R:N404	13.5938	13.46	Yes	No	1	7	9
28	R:R:C128	R:R:M211	48.9388	4.86	No	Yes	0	7	9
29	R:R:C128	R:R:L210	47.7113	3.17	No	No	0	7	7
30	R:R:L210	R:R:L214	46.4737	5.54	No	No	0	7	7
31	R:R:L132	R:R:L214	29.4533	4.15	No	No	0	6	7
32	R:R:L132	R:R:W136	28.0724	11.39	No	No	0	6	5
33	R:R:R152	R:R:W136	26.6762	7	No	No	0	7	5
34	R:R:R148	R:R:R152	22.549	4.26	Yes	No	0	8	7
35	R:R:R148	R:R:V70	12.3101	15.69	Yes	No	0	8	7
36	L:L:?1	R:R:V117	32.7725	8.77	Yes	No	0	0	8
37	R:R:S168	R:R:V117	31.6371	4.85	No	No	0	8	8
38	R:R:L118	R:R:S168	27.8167	3	No	No	0	6	8
39	R:R:L118	R:R:W161	25.2186	5.69	No	Yes	0	6	9
40	R:R:L78	R:R:Y400	11.2259	3.52	No	Yes	1	9	9
41	R:R:C109	R:R:D110	18.0382	3.11	Yes	No	0	9	7
42	R:R:D110	R:R:R181	16.8158	4.76	No	No	0	7	4
43	L:L:?1	R:R:T121	11.4356	5.42	Yes	No	0	0	8
44	R:R:L214	R:R:Y135	18.2223	4.69	No	Yes	0	7	9
45	R:R:I189	R:R:Y195	11.4151	3.63	Yes	Yes	0	6	8
46	L:L:?1	R:R:S199	10.3207	6.63	Yes	No	0	0	8
47	R:R:D192	R:R:Y195	10.1826	2.3	No	Yes	0	6	8
48	R:R:R176	R:R:R181	15.5833	10.66	No	No	0	6	4
49	R:R:D180	R:R:R176	13.0875	8.34	No	No	0	4	6
50	L:L:?1	R:R:F362	13.7728	12.54	Yes	Yes	2	0	7
51	R:R:F204	R:R:F362	21.2755	19.29	Yes	Yes	0	8	7
52	R:R:F204	R:R:Y205	19.6492	5.16	Yes	Yes	0	8	7
53	R:R:F201	R:R:Y205	15.5782	14.44	No	Yes	6	5	7
54	R:R:F201	R:R:I197	14.3149	3.77	No	No	0	5	7
55	R:R:F370	R:R:I197	12.929	5.02	No	No	0	5	7
56	R:R:L347	R:R:Y215	18.2683	4.69	No	Yes	0	8	9
57	R:R:F219	R:R:L347	16.78	3.65	Yes	No	0	6	8
58	L:L:?1	R:R:F361	11.0418	8.96	Yes	Yes	2	0	8
59	R:R:F361	R:R:N386	21.5466	4.83	Yes	No	0	8	7
60	R:R:I385	R:R:N386	18.4984	2.83	No	No	0	6	7
61	R:R:F361	R:R:W358	10.7196	5.01	Yes	Yes	2	8	8
62	R:R:R134	R:R:Y400	15.1639	6.17	Yes	Yes	1	9	9
63	R:R:F204	R:R:F354	17.046	5.36	Yes	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D116	17.97	2	Yes	No	0	8	0	1
L:L:?1	R:R:V117	8.77	2	Yes	No	0	8	0	1
L:L:?1	R:R:C120	9.34	2	Yes	No	0	7	0	1
L:L:?1	R:R:T121	5.42	2	Yes	No	0	8	0	1
L:L:?1	R:R:I124	4.2	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:I189	4.2	2	Yes	Yes	0	6	0	1
L:L:?1	R:R:S199	6.63	2	Yes	No	0	8	0	1
L:L:?1	R:R:A203	3.48	2	Yes	No	0	8	0	1
L:L:?1	R:R:W358	10.89	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:F361	8.96	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:F362	12.54	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:Y390	3.45	2	Yes	Yes	0	8	0	1
R:R:C120	R:R:V85	3.42	0	No	No	7	8	1	2
R:R:D116	R:R:V89	4.38	2	No	No	8	8	1	2
R:R:V89	R:R:Y390	3.79	2	No	Yes	8	8	2	1
R:R:L90	R:R:Y390	5.86	0	Yes	Yes	8	8	2	1
R:R:D116	R:R:Y390	9.2	2	No	Yes	8	8	1	1
R:R:S168	R:R:V117	4.85	0	No	No	8	8	2	1
R:R:G164	R:R:T121	3.64	0	No	No	8	8	2	1
R:R:I167	R:R:T121	4.56	0	No	No	8	8	2	1
R:R:I124	R:R:P207	3.39	2	Yes	No	8	9	1	2
R:R:F354	R:R:I124	7.54	0	Yes	Yes	9	8	2	1
R:R:I124	R:R:W358	8.22	2	Yes	Yes	8	8	1	1
R:R:I189	R:R:K191	4.36	0	Yes	No	6	5	1	2
R:R:I189	R:R:Y195	3.63	0	Yes	Yes	6	8	1	2
R:R:S199	R:R:Y195	15.26	0	No	Yes	8	8	1	2
R:R:F204	R:R:F354	5.36	0	Yes	Yes	8	9	2	2
R:R:F204	R:R:F362	19.29	0	Yes	Yes	8	7	2	1
R:R:F361	R:R:W358	5.01	2	Yes	Yes	8	8	1	1
R:R:F362	R:R:W358	6.01	2	Yes	Yes	7	8	1	1
R:R:G389	R:R:W358	8.44	0	No	Yes	8	8	2	1
R:R:N392	R:R:W358	6.78	0	No	Yes	9	8	2	1
R:R:F361	R:R:F362	11.79	2	Yes	Yes	8	7	1	1
R:R:F361	R:R:N386	4.83	2	Yes	No	8	7	1	2
R:R:W387	R:R:Y390	8.68	0	Yes	Yes	8	8	2	1
R:R:I113	R:R:I189	2.94	5	No	Yes	7	6	2	1
R:R:A365	R:R:F361	2.77	0	No	Yes	8	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:G53	R:R:Y402	4.35	0	No	Yes	9	6	2	1
R:R:V57	R:R:Y402	5.05	0	No	Yes	9	6	2	1
R:R:I130	R:R:R134	6.26	1	No	Yes	9	9	2	1
R:R:I130	R:R:Y400	8.46	1	No	Yes	9	9	2	2
R:R:R134	R:R:Y215	7.2	1	Yes	Yes	9	9	1	2
R:R:R134	R:R:Y400	6.17	1	Yes	Yes	9	9	1	2
R:R:R134	W:W:?1	3.25	1	Yes	Yes	9	0	1	0
R:R:I349	R:R:K345	4.36	1	No	No	7	7	1	1
R:R:K345	W:W:?1	3.78	1	No	Yes	7	0	1	0
R:R:T346	W:W:?1	10.85	0	No	Yes	8	0	1	0
R:R:I349	R:R:I399	4.42	1	No	No	7	8	1	2
R:R:I349	W:W:?1	5.73	1	No	Yes	7	0	1	0
R:R:F403	R:R:V398	5.24	0	No	No	8	6	1	2
R:R:F411	R:R:Y402	6.19	0	Yes	Yes	8	6	2	1
R:R:Y402	W:W:?1	6.28	0	Yes	Yes	6	0	1	0
R:R:F403	W:W:?1	30.17	0	No	Yes	8	0	1	0
R:R:D406	R:R:N404	13.46	1	Yes	No	7	9	2	1
R:R:F407	R:R:N404	12.08	1	Yes	No	8	9	2	1
R:R:N404	W:W:?1	4.6	1	No	Yes	9	0	1	0
R:R:D406	R:R:F407	4.78	1	Yes	Yes	7	8	2	2
R:R:F407	R:R:F411	5.36	1	Yes	Yes	8	8	2	2
R:R:K342	R:R:T346	1.5	0	No	No	8	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9DYD_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	266
Number of Links	291
Number of Hubs	36
Number of Links mediated by Hubs	135
Number of Communities	7
Number of Nodes involved in Communities	51
Number of Links involved in Communities	71

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	43283
Length Of Smallest Path	3
Average Path Length	12.3108
Length of Longest Path	28
Minimum Path Strength	1.17
Average Path Strength	5.78044
Maximum Path Strength	20.51
Minimum Path Correlation	0.7
Average Path Correlation	0.937044
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5.88235
Average % Of Corr. Nodes	55.9984
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.1286
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cation binding • binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • protein binding • signaling receptor binding • receptor-receptor interaction • tetrapyrrole binding • heme binding • electron transfer activity • transition metal ion binding • iron ion binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • behavior • multicellular organismal process • exploration behavior • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • adult behavior • regulation of tube diameter • system process • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • cell-cell signaling • gamma-aminobutyric acid signaling pathway • regulation of behavior • serotonin metabolic process • indole-containing compound metabolic process • cellular response to nitrogen compound • response to dopamine • serotonin receptor signaling pathway • cellular response to dopamine • response to monoamine • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to catecholamine • cellular response to monoamine stimulus • response to chemical • cellular response to catecholamine stimulus • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • monoatomic ion transport • serotonin secretion • regulation of monoatomic ion transport • regulation of serotonin secretion • serotonin transport • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • electron transport chain • generation of precursor metabolites and energy • cell periphery • cellular anatomical structure • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • synapse • cell junction • periplasmic space • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • mu-type opioid receptor binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • cation binding • metal ion binding • heart process • regulation of heart contraction • heart contraction • locomotory behavior • membrane docking • vesicle-mediated transport • organelle localization by membrane tethering • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • negative regulation of protein transport • establishment of protein localization • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • negative regulation of cellular process • negative regulation of protein localization • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • insulin secretion • modulation of chemical synaptic transmission • regulation of trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • GABA-ergic synapse • glutamatergic synapse • cell body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


Code	J40
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	J40
Name	[(2R)-1-[oxidanyl-[(2R,3R,5S,6R)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5E,8E)-hexadeca-5,8,11,14-tetraenoate
Synonyms
Identifier
Formula	C39 H68 O16 P2
Molecular Weight	854.895
SMILES
PubChem
Formal Charge	0
Total Atoms	125
Total Chiral Atoms	5
Total Bonds	125
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08908
Sequence	>9DYD_nogp_Chain_R Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E R S L Q N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N K W T L G Q V T C D L F I A L D V L C C T S S I H L C A I A L D R Y W A I T D P I D Y V N K R T P R R A A A L I S L T W L I G F L I S I P P M L G W R T P E D R S D P D A C T I S K D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C E S S C H M P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F Q N A F K K I I W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7E2X	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	PtdIns4P	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2X (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	PtdIns4P		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	PtdIns4P	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	PtdIns4P		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	PtdIns4P	Gi1/β1/γ2	3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	PtdIns4P		3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	8JSP	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-	Gi1/β1/γ2	3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSP (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-		3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8W8B	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-	Gi1/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8B (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8FY8	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P	Gi1/β1/γ1	2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FY8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P		2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	PtdIns4P	Gi1/β1/γ1	2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	PtdIns4P		2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	PtdIns4P	Gi1/β1/γ1	2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	PtdIns4P		2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	PtdIns4P	Gi1/β1/γ1	2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	PtdIns4P		2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gi1/β1/γ1	2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8PJK	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-	Gi1/β1/γ1	2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PJK (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-		2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gi1/β1/γ1	2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8JT6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	PtdIns4P	Gi1/β1/γ2	3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8JT6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	PtdIns4P		3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	9GL2	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gs/β1/γ2	3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9GL2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9DYD	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P	Go/β1/γ2	2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P		2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Go/β1/γ2	2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P	Gi1/β1/γ2	2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P		2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9VJ5	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Gepirone	-	Go/β1/γ2	2.69	2025-11-12	To be published
	9VJ5 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Gepirone	-		2.69	2025-11-12	To be published
	9VJ6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	F-15599	-	Gi3/β1/γ2	2.62	2025-11-12	To be published
	9VJ6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	F-15599	-		2.62	2025-11-12	To be published
	9VJE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Go/β1/γ2	2.47	2025-11-12	To be published
	9VJE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.47	2025-11-12	To be published
	9VJF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gi3/β1/γ2	2.7	2025-11-12	To be published
	9VJF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.7	2025-11-12	To be published
	9VJG	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	8-OH-DPAT	-	chim(NtGi2-Gz)/β1/γ2	2.67	2025-11-12	To be published
	9VJG (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	8-OH-DPAT	-		2.67	2025-11-12	To be published
	9VMY	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	TMU4142	-	Go/β1/γ2	2.86	2025-11-12	To be published
	9VMY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	TMU4142	-		2.86	2025-11-12	To be published
	9VNF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Pindolol	-	Go/β1/γ2	2.74	2025-11-12	To be published
	9VNF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Pindolol	-		2.74	2025-11-12	To be published
	9KVG	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P	Gi1/β1/γ2	2.63	2025-12-03	To be published
	9KVG (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P		2.63	2025-12-03	To be published
	9KVH	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Cinobufotenine	PtdIns4P	Gi1/β1/γ2	2.59	2025-12-03	To be published
	9KVH (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Cinobufotenine	PtdIns4P		2.59	2025-12-03	To be published
	9KVI	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Bufotenin	PtdIns4P	Gi1/β1/γ2	2.54	2025-12-03	To be published
	9KVI (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Bufotenin	PtdIns4P		2.54	2025-12-03	To be published
	9HYI	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	DP81	-	Gi1/β1/γ2	2.3	2026-01-21	To be published
	9HYI (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	DP81	-		2.3	2026-01-21	To be published

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Download 9DYD_nogp.zip

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