psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D116	19.49	Yes	Yes	1	0	8
2	L:L:?1	R:R:V117	9.51	Yes	No	0	0	8
3	L:L:?1	R:R:C120	10.13	Yes	No	1	0	7
4	L:L:?1	R:R:T121	5.88	Yes	No	0	0	8
5	L:L:?1	R:R:I124	4.55	Yes	Yes	1	0	8
6	L:L:?1	R:R:I189	4.55	Yes	Yes	0	0	6
7	L:L:?1	R:R:S199	7.19	Yes	No	0	0	8
8	L:L:?1	R:R:A203	3.77	Yes	No	0	0	8
9	L:L:?1	R:R:W358	11.81	Yes	Yes	1	0	8
10	L:L:?1	R:R:F361	9.72	Yes	Yes	1	0	8
11	L:L:?1	R:R:F362	13.6	Yes	Yes	1	0	7
12	L:L:?1	R:R:Y390	3.74	Yes	Yes	1	0	8
13	R:R:Q36	R:R:T39	9.92	No	No	5	4	5
14	R:R:Q36	R:R:V98	5.73	No	Yes	5	4	6
15	R:R:L41	R:R:V37	2.98	No	No	0	4	5
16	R:R:T39	R:R:V98	4.76	No	Yes	5	5	6
17	R:R:A94	R:R:L43	3.15	No	No	0	7	7
18	R:R:L43	R:R:W387	11.39	No	Yes	0	7	8
19	R:R:I47	R:R:L90	4.28	No	Yes	0	7	8
20	R:R:C49	R:R:L394	3.17	No	No	0	5	7
21	R:R:A50	R:R:S86	3.42	No	No	0	8	8
22	R:R:L83	R:R:V51	2.98	No	No	0	8	7
23	R:R:G53	R:R:Y402	4.35	No	Yes	0	9	6
24	R:R:D82	R:R:N54	5.39	Yes	No	0	9	9
25	R:R:N54	R:R:P397	6.52	No	No	0	9	9
26	R:R:A79	R:R:V57	3.39	No	No	0	9	9
27	R:R:A401	R:R:V57	3.39	No	No	0	8	9
28	R:R:V57	R:R:Y402	5.05	No	Yes	0	9	6
29	R:R:V58	R:R:V80	3.21	No	No	0	7	7
30	R:R:A60	R:R:F411	4.16	No	Yes	0	8	8
31	R:R:F407	R:R:I61	5.02	Yes	No	0	8	8
32	R:R:A410	R:R:E64	3.02	No	No	0	8	7
33	R:R:E64	R:R:K413	13.5	No	No	0	7	6
34	R:R:Q68	R:R:R65	5.84	No	No	0	8	7
35	R:R:L67	R:R:S66	3	Yes	No	0	8	6
36	R:R:L67	R:R:N72	4.12	Yes	Yes	3	8	9
37	R:R:D406	R:R:L67	4.07	Yes	Yes	3	7	8
38	R:R:F407	R:R:L67	6.09	Yes	Yes	3	8	8
39	R:R:A410	R:R:L67	3.15	No	Yes	0	8	8
40	R:R:Q68	R:R:Y73	3.38	No	No	0	8	6
41	R:R:N69	R:R:N72	12.26	No	Yes	3	8	9
42	R:R:R148	R:R:V70	15.69	Yes	No	0	8	7
43	R:R:P150	R:R:V70	3.53	No	No	0	5	7
44	R:R:D406	R:R:N72	5.39	Yes	Yes	3	7	9
45	R:R:F407	R:R:N72	6.04	Yes	Yes	3	8	9
46	R:R:D133	R:R:L74	4.07	No	No	0	9	8
47	R:R:L156	R:R:L74	4.15	No	No	8	6	8
48	R:R:H126	R:R:S77	6.97	Yes	No	4	8	9
49	R:R:I157	R:R:S77	10.84	No	No	4	8	9
50	R:R:D82	R:R:L78	5.43	Yes	No	2	9	9
51	R:R:L78	R:R:N396	6.87	No	Yes	2	9	9
52	R:R:L78	R:R:Y400	3.52	No	Yes	2	9	9
53	R:R:S122	R:R:T81	6.4	Yes	No	4	8	9
54	R:R:H126	R:R:T81	8.21	Yes	No	4	8	9
55	R:R:T81	R:R:W161	8.49	No	Yes	4	9	9
56	R:R:D82	R:R:S123	5.89	Yes	No	0	9	9
57	R:R:D82	R:R:S393	4.42	Yes	No	0	9	9
58	R:R:D82	R:R:N396	6.73	Yes	Yes	2	9	9
59	R:R:C119	R:R:M84	3.24	No	No	0	7	7
60	R:R:M84	R:R:W161	3.49	No	Yes	0	7	9
61	R:R:L90	R:R:V85	2.98	Yes	No	0	8	8
62	R:R:C120	R:R:V85	3.42	No	No	0	7	8
63	R:R:L90	R:R:S86	3	Yes	No	0	8	8
64	R:R:D116	R:R:V89	4.38	Yes	No	1	8	8
65	R:R:V89	R:R:Y390	3.79	No	Yes	1	8	8
66	R:R:L90	R:R:Y390	5.86	Yes	Yes	0	8	8
67	R:R:F112	R:R:M92	6.22	No	No	0	6	6
68	R:R:L95	R:R:L99	4.15	No	No	5	6	5
69	R:R:W102	R:R:Y96	9.65	Yes	No	0	9	6
70	R:R:A383	R:R:Q97	4.55	No	No	0	6	7
71	R:R:Q97	R:R:W387	5.48	No	Yes	0	7	8
72	R:R:L99	R:R:V98	2.98	No	Yes	5	5	6
73	R:R:K101	R:R:T103	3	No	No	0	5	5
74	R:R:L104	R:R:W102	7.97	No	Yes	0	7	9
75	R:R:C109	R:R:W102	6.53	Yes	Yes	6	9	9
76	R:R:F112	R:R:W102	7.02	No	Yes	0	6	9
77	R:R:C187	R:R:W102	16.98	No	Yes	6	9	9
78	R:R:L104	R:R:T108	7.37	No	No	0	7	6
79	R:R:C109	R:R:D110	3.11	Yes	No	0	9	7
80	R:R:C109	R:R:I113	3.27	Yes	No	6	9	7
81	R:R:C109	R:R:C187	7.28	Yes	No	6	9	9
82	R:R:D110	R:R:R181	4.76	No	No	0	7	4
83	R:R:C187	R:R:I113	3.27	No	No	6	9	7
84	R:R:I113	R:R:I189	2.94	No	Yes	0	7	6
85	R:R:C120	R:R:D116	3.11	No	Yes	1	7	8
86	R:R:D116	R:R:Y390	9.2	Yes	Yes	1	8	8
87	R:R:I167	R:R:V117	3.07	No	No	0	8	8
88	R:R:S168	R:R:V117	4.85	No	No	0	8	8
89	R:R:L118	R:R:W161	5.69	No	Yes	0	6	9
90	R:R:F165	R:R:L118	9.74	No	No	0	5	6
91	R:R:L118	R:R:S168	3	No	No	0	6	8
92	R:R:G164	R:R:T121	3.64	No	No	0	8	8
93	R:R:I167	R:R:T121	4.56	No	No	0	8	8
94	R:R:H126	R:R:S122	4.18	Yes	Yes	4	8	8
95	R:R:S122	R:R:T160	3.2	Yes	No	4	8	8
96	R:R:S122	R:R:W161	18.53	Yes	Yes	4	8	9
97	R:R:I124	R:R:P207	3.39	Yes	No	0	8	9
98	R:R:F354	R:R:I124	7.54	Yes	Yes	0	9	8
99	R:R:I124	R:R:W358	8.22	Yes	Yes	1	8	8
100	R:R:I163	R:R:W125	12.92	No	No	0	5	7
101	R:R:P207	R:R:W125	14.86	No	No	0	9	7
102	R:R:H126	R:R:I157	3.98	Yes	No	4	8	8
103	R:R:H126	R:R:T160	17.8	Yes	No	4	8	8
104	R:R:L127	R:R:N396	5.49	No	Yes	0	8	9
105	R:R:L127	R:R:Y400	5.86	No	Yes	0	8	9
106	R:R:C128	R:R:L210	3.17	No	No	0	7	7
107	R:R:C128	R:R:M211	4.86	No	Yes	0	7	9
108	R:R:I130	R:R:R134	6.26	No	No	2	9	9
109	R:R:I130	R:R:Y400	8.46	No	Yes	2	9	9
110	R:R:A131	R:R:Y215	6.67	No	Yes	0	9	9
111	R:R:L132	R:R:W136	11.39	No	No	0	6	5
112	R:R:L132	R:R:L214	4.15	No	No	0	6	7
113	R:R:D133	R:R:R148	10.72	No	Yes	0	9	8
114	R:R:R134	R:R:Y215	7.2	No	Yes	2	9	9
115	R:R:R134	R:R:Y400	6.17	No	Yes	2	9	9
116	R:R:T139	R:R:Y135	12.48	No	Yes	0	8	9
117	R:R:L214	R:R:Y135	4.69	No	Yes	0	7	9
118	R:R:R217	R:R:Y135	12.35	No	Yes	0	7	9
119	R:R:I218	R:R:Y135	3.63	No	Yes	0	9	9
120	R:R:R152	R:R:W136	7	No	No	0	7	5
121	R:R:D140	R:R:T139	4.34	No	No	0	7	8
122	R:R:D143	R:R:K147	4.15	No	No	0	6	5
123	R:R:D143	R:R:R152	10.72	No	No	0	6	7
124	R:R:R148	R:R:Y144	11.32	Yes	No	0	8	8
125	R:R:N146	R:R:V145	4.43	No	No	0	5	6
126	R:R:R148	R:R:R152	4.26	Yes	No	0	8	7
127	R:R:T160	R:R:W161	4.85	No	Yes	4	8	9
128	R:R:I167	R:R:Y198	6.04	No	No	0	8	5
129	R:R:I169	R:R:P170	3.39	No	No	0	6	8
130	R:R:P170	R:R:P171	5.84	No	No	0	8	7
131	R:R:P171	R:R:Y195	12.52	No	Yes	0	7	8
132	R:R:D192	R:R:W175	3.35	No	No	0	6	6
133	R:R:D180	R:R:R176	8.34	No	No	0	4	6
134	R:R:R176	R:R:R181	10.66	No	No	0	6	4
135	R:R:R176	R:R:S190	3.95	No	No	0	6	6
136	R:R:E179	R:R:T177	4.23	No	No	0	3	5
137	R:R:E179	R:R:P178	3.14	No	No	0	3	5
138	R:R:D180	R:R:T188	5.78	No	No	0	4	5
139	R:R:D183	R:R:P184	6.44	No	No	0	1	1
140	R:R:D183	R:R:D185	11.98	No	No	0	1	4
141	R:R:A186	R:R:D183	4.63	No	No	0	4	1
142	R:R:I189	R:R:K191	4.36	Yes	No	0	6	5
143	R:R:I189	R:R:Y195	3.63	Yes	Yes	0	6	8
144	R:R:D192	R:R:G194	5.03	No	No	0	6	5
145	R:R:F370	R:R:H193	28.28	No	No	0	5	4
146	R:R:E372	R:R:H193	6.15	No	No	0	3	4
147	R:R:S199	R:R:Y195	15.26	No	Yes	0	8	8
148	R:R:P369	R:R:T196	8.74	No	No	0	7	7
149	R:R:F370	R:R:T196	3.89	No	No	0	5	7
150	R:R:F201	R:R:I197	3.77	No	No	0	5	7
151	R:R:F370	R:R:I197	5.02	No	No	0	5	7
152	R:R:T200	R:R:Y205	6.24	No	Yes	7	7	7
153	R:R:L366	R:R:T200	5.9	No	No	7	7	7
154	R:R:F201	R:R:Y205	14.44	No	Yes	7	5	7
155	R:R:F201	R:R:L366	3.65	No	No	7	5	7
156	R:R:F204	R:R:Y205	5.16	Yes	Yes	0	8	7
157	R:R:F204	R:R:F354	5.36	Yes	Yes	0	8	9
158	R:R:F204	R:R:L359	6.09	Yes	Yes	0	8	7
159	R:R:F204	R:R:F362	19.29	Yes	Yes	0	8	7
160	R:R:L366	R:R:Y205	8.21	No	Yes	7	7	7
161	R:R:I206	R:R:P207	3.39	No	No	0	6	9
162	R:R:L208	R:R:L212	4.15	No	No	0	7	6
163	R:R:F354	R:R:L208	3.65	Yes	No	0	9	7
164	R:R:L210	R:R:L214	5.54	No	No	0	7	7
165	R:R:M211	R:R:Y215	3.59	Yes	Yes	2	9	9
166	R:R:M211	R:R:M351	4.33	Yes	No	2	9	8
167	R:R:F354	R:R:M211	3.73	Yes	Yes	0	9	9
168	R:R:R217	R:R:V213	5.23	No	No	0	7	5
169	R:R:L347	R:R:Y215	4.69	No	Yes	0	8	9
170	R:R:I350	R:R:Y215	7.25	No	Yes	0	8	9
171	R:R:M351	R:R:Y215	3.59	No	Yes	2	8	9
172	R:R:F219	R:R:R223	9.62	Yes	No	0	6	7
173	R:R:F219	R:R:T343	7.78	Yes	No	0	6	8
174	R:R:F219	R:R:L347	3.65	Yes	No	0	6	8
175	R:R:R223	R:R:R227	12.79	No	No	0	7	6
176	R:R:E340	R:R:R223	8.14	No	No	0	8	7
177	R:R:F224	R:R:K228	4.96	No	No	0	6	5
178	R:R:K228	R:R:R225	4.95	No	No	0	5	7
179	R:R:I226	R:R:R339	3.76	No	No	0	6	7
180	R:R:I226	R:R:T343	3.04	No	No	0	6	8
181	R:R:N325	R:R:N328	4.09	No	No	0	5	3
182	R:R:E326	R:R:R327	6.98	No	No	0	3	3
183	R:R:A329	R:R:E326	4.53	No	No	0	5	3
184	R:R:E330	R:R:R333	5.82	No	No	0	4	4
185	R:R:M335	R:R:R339	6.2	No	No	0	4	7
186	R:R:I349	R:R:K345	4.36	No	No	0	7	7
187	R:R:I349	R:R:I399	4.42	No	No	0	7	8
188	R:R:L395	R:R:T353	2.95	No	No	0	6	7
189	R:R:I399	R:R:T353	3.04	No	No	0	8	7
190	R:R:I355	R:R:L359	4.28	No	Yes	0	7	7
191	R:R:C357	R:R:N392	6.3	No	No	0	8	9
192	R:R:F361	R:R:W358	5.01	Yes	Yes	1	8	8
193	R:R:F362	R:R:W358	6.01	Yes	Yes	1	7	8
194	R:R:G389	R:R:W358	8.44	No	Yes	0	8	8
195	R:R:N392	R:R:W358	6.78	No	Yes	0	9	8
196	R:R:L359	R:R:P360	3.28	Yes	No	0	7	9
197	R:R:I363	R:R:L359	5.71	No	Yes	0	7	7
198	R:R:F361	R:R:F362	11.79	Yes	Yes	1	8	7
199	R:R:F361	R:R:N386	4.83	Yes	No	0	8	7
200	R:R:M377	R:R:V364	7.61	No	No	0	4	6
201	R:R:I385	R:R:V364	4.61	No	No	0	6	6
202	R:R:L368	R:R:P369	3.28	No	No	0	4	7
203	R:R:S373	R:R:S374	3.26	No	No	0	3	5
204	R:R:L381	R:R:P378	6.57	No	No	0	6	7
205	R:R:I384	R:R:L380	5.71	No	No	0	4	3
206	R:R:G382	R:R:I385	3.53	No	No	0	4	6
207	R:R:W387	R:R:Y390	8.68	Yes	Yes	0	8	8
208	R:R:N392	R:R:N396	12.26	No	Yes	0	9	9
209	R:R:F403	R:R:V398	5.24	No	No	0	8	6
210	R:R:A401	R:R:F407	8.32	No	Yes	0	8	8
211	R:R:F411	R:R:Y402	6.19	Yes	Yes	0	8	6
212	R:R:D406	R:R:N404	13.46	Yes	No	3	7	9
213	R:R:F407	R:R:N404	12.08	Yes	No	3	8	9
214	R:R:K405	R:R:Q408	4.07	No	No	0	6	9
215	R:R:D406	R:R:F407	4.78	Yes	Yes	3	7	8
216	R:R:F407	R:R:F411	5.36	Yes	Yes	0	8	8
217	R:R:L88	R:R:M84	2.83	No	No	0	6	7
218	R:R:I385	R:R:N386	2.83	No	No	0	6	7
219	R:R:G174	R:R:W175	2.81	No	No	0	5	6
220	R:R:C56	R:R:F411	2.79	No	Yes	0	8	8
221	R:R:P397	R:R:Y402	2.78	No	Yes	0	9	6
222	R:R:A93	R:R:F112	2.77	No	No	0	7	6
223	R:R:L104	R:R:L95	2.77	No	No	0	7	6
224	R:R:L111	R:R:L115	2.77	No	No	0	5	5
225	R:R:A365	R:R:F361	2.77	No	Yes	0	8	8
226	R:R:L83	R:R:N54	2.75	No	No	0	8	9
227	R:R:A137	R:R:Y144	2.67	No	No	0	8	8
228	R:R:F219	R:R:V344	2.62	Yes	No	0	6	8
229	R:R:R151	R:R:T149	2.59	No	No	0	6	8
230	R:R:E326	R:R:E330	2.54	No	No	0	3	4
231	R:R:V398	R:R:Y402	2.52	No	Yes	0	6	6
232	R:R:F48	R:R:L52	2.44	No	No	0	4	4
233	R:R:I399	R:R:Y400	2.42	No	Yes	0	8	9
234	R:R:D192	R:R:Y195	2.3	No	Yes	0	6	8
235	R:R:L46	R:R:W387	2.28	No	Yes	0	7	8
236	R:R:A79	R:R:G76	1.95	No	No	0	9	6
237	R:R:C371	R:R:C375	1.82	No	No	0	5	4
238	R:R:G202	R:R:I206	1.76	No	No	0	5	6
239	R:R:P150	R:R:T149	1.75	No	No	0	5	8
240	R:R:G352	R:R:M351	1.75	No	No	0	6	8
241	R:R:C357	R:R:S391	1.72	No	No	0	8	5
242	R:R:G53	R:R:L52	1.71	No	No	0	9	4
243	R:R:A114	R:R:S168	1.71	No	No	0	7	8
244	R:R:C371	R:R:V367	1.71	No	No	0	5	6
245	R:R:G382	R:R:L381	1.71	No	No	0	4	6
246	R:R:A79	R:R:V58	1.7	No	No	0	9	7
247	R:R:A153	R:R:V70	1.7	No	No	0	7	7
248	R:R:C49	R:R:T45	1.69	No	No	0	5	4
249	R:R:I142	R:R:P141	1.69	No	No	0	6	8
250	R:R:A186	R:R:T188	1.68	No	No	0	4	5
251	R:R:A222	R:R:T343	1.68	No	No	0	8	8
252	R:R:L90	R:R:P91	1.64	Yes	No	0	8	9
253	R:R:L388	R:R:P360	1.64	No	No	0	8	9
254	R:R:S40	R:R:V98	1.62	No	Yes	0	5	6
255	R:R:A60	R:R:I414	1.62	No	No	0	8	7
256	R:R:A401	R:R:I75	1.62	No	No	0	8	8
257	R:R:A221	R:R:I138	1.62	No	No	0	6	9
258	R:R:A336	R:R:I226	1.62	No	No	0	5	6
259	R:R:A114	R:R:M172	1.61	No	No	0	7	6
260	R:R:D140	R:R:P141	1.61	No	No	0	7	8
261	R:R:V51	R:R:V87	1.6	No	No	0	7	6
262	R:R:C119	R:R:L115	1.59	No	No	0	7	5
263	R:R:C375	R:R:L368	1.59	No	No	0	4	4
264	R:R:A50	R:R:L394	1.58	No	No	0	8	7
265	R:R:A55	R:R:L83	1.58	No	No	0	5	8
266	R:R:A129	R:R:L74	1.58	No	No	8	8	8
267	R:R:P184	R:R:Q106	1.58	No	No	0	1	4
268	R:R:A129	R:R:L156	1.58	No	No	8	8	6
269	R:R:A71	R:R:N69	1.56	No	No	3	8	8
270	R:R:A71	R:R:N72	1.56	No	Yes	3	8	9
271	R:R:I350	R:R:T346	1.52	No	No	0	8	8
272	R:R:L159	R:R:S158	1.5	No	No	0	3	5
273	R:R:K342	R:R:T346	1.5	No	No	0	8	8
274	R:R:L95	R:R:T103	1.47	No	No	5	6	5
275	R:R:L99	R:R:T103	1.47	No	No	5	5	5
276	R:R:I138	R:R:I218	1.47	No	No	0	9	9
277	R:R:I414	R:R:I415	1.47	No	No	0	7	7
278	R:R:D180	R:R:T177	1.45	No	No	0	4	5
279	R:R:I38	R:R:L42	1.43	No	No	0	3	5
280	R:R:I414	R:R:L63	1.43	No	No	0	7	6
281	R:R:I142	R:R:N146	1.42	No	No	0	6	5
282	R:R:G105	R:R:W102	1.41	No	Yes	0	7	9
283	R:R:K324	R:R:N325	1.4	No	No	0	1	5
284	R:R:P150	R:R:Y73	1.39	No	No	0	5	6
285	R:R:L159	R:R:L162	1.38	No	No	0	3	5
286	R:R:L162	R:R:L166	1.38	No	No	0	5	5
287	R:R:E330	R:R:K334	1.35	No	No	0	4	5
288	R:R:N409	R:R:Q408	1.32	No	No	0	6	9
289	R:R:I38	R:R:Y35	1.21	No	No	0	3	4
290	R:R:L166	R:R:Y198	1.17	No	No	0	5	5
291	R:R:Q36	R:R:Y35	1.13	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.66167	12	1	0
2	R:R:L67	4.086	5	3	8
3	R:R:N72	5.874	5	3	9
4	R:R:D82	5.572	5	2	9
5	R:R:L90	3.552	5	0	8
6	R:R:V98	3.7725	4	5	6
7	R:R:W102	8.26	6	6	9
8	R:R:C109	5.0475	4	6	9
9	R:R:D116	9.045	4	1	8
10	R:R:S122	8.0775	4	4	8
11	R:R:I124	5.925	4	1	8
12	R:R:H126	8.228	5	4	8
13	R:R:Y135	8.2875	4	0	9
14	R:R:R148	10.4975	4	0	8
15	R:R:W161	8.21	5	4	9
16	R:R:I189	3.87	4	0	6
17	R:R:Y195	8.4275	4	0	8
18	R:R:F204	8.975	4	0	8
19	R:R:Y205	8.5125	4	7	7
20	R:R:M211	4.1275	4	2	9
21	R:R:Y215	5.49833	6	2	9
22	R:R:F219	5.9175	4	0	6
23	R:R:F354	5.07	4	0	9
24	R:R:W358	7.71167	6	1	8
25	R:R:L359	4.84	4	0	7
26	R:R:F361	6.824	5	1	8
27	R:R:F362	12.6725	4	1	7
28	R:R:W387	6.9575	4	0	8
29	R:R:Y390	6.254	5	1	8
30	R:R:N396	7.8375	4	2	9
31	R:R:Y400	5.286	5	2	9
32	R:R:Y402	4.178	5	0	6
33	R:R:D406	6.925	4	3	7
34	R:R:F407	6.81286	7	3	8
35	R:R:F411	4.625	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:I189	100	4.55	Yes	Yes	0	0	6
2	R:R:I113	R:R:I189	89.0665	2.94	No	Yes	0	7	6
3	R:R:C109	R:R:I113	55.4173	3.27	Yes	No	6	9	7
4	R:R:C109	R:R:W102	32.9279	6.53	Yes	Yes	6	9	9
5	R:R:L104	R:R:W102	44.4908	7.97	No	Yes	0	7	9
6	R:R:L104	R:R:L95	37.8006	2.77	No	No	0	7	6
7	R:R:L95	R:R:L99	27.546	4.15	No	No	5	6	5
8	R:R:L99	R:R:V98	24.2504	2.98	No	Yes	5	5	6
9	R:R:Q36	R:R:V98	13.9109	5.73	No	Yes	5	4	6
10	R:R:C187	R:R:I113	32.5389	3.27	No	No	6	9	7
11	R:R:C187	R:R:W102	31.0396	16.98	No	Yes	6	9	9
12	L:L:?1	R:R:Y390	30.2617	3.74	Yes	Yes	1	0	8
13	R:R:W387	R:R:Y390	11.7822	8.68	Yes	Yes	0	8	8
14	R:R:L90	R:R:Y390	15.8133	5.86	Yes	Yes	0	8	8
15	R:R:L90	R:R:S86	10.1061	3	Yes	No	0	8	8
16	L:L:?1	R:R:W358	58.6846	11.81	Yes	Yes	1	0	8
17	R:R:N392	R:R:W358	73.4653	6.78	No	Yes	0	9	8
18	R:R:N392	R:R:N396	70.5587	12.26	No	Yes	0	9	9
19	R:R:D82	R:R:N396	50.9123	6.73	Yes	Yes	2	9	9
20	R:R:D82	R:R:N54	64.6252	5.39	Yes	No	0	9	9
21	R:R:N54	R:R:P397	57.0226	6.52	No	No	0	9	9
22	R:R:P397	R:R:Y402	55.4597	2.78	No	Yes	0	9	6
23	R:R:V57	R:R:Y402	13.0269	5.05	No	Yes	0	9	6
24	R:R:F411	R:R:Y402	33.1754	6.19	Yes	Yes	0	8	6
25	R:R:F407	R:R:F411	22.5672	5.36	Yes	Yes	0	8	8
26	L:L:?1	R:R:I124	66.181	4.55	Yes	Yes	1	0	8
27	R:R:F354	R:R:I124	70.8204	7.54	Yes	Yes	0	9	8
28	R:R:F354	R:R:M211	79.8373	3.73	Yes	Yes	0	9	9
29	R:R:C128	R:R:M211	66.4498	4.86	No	Yes	0	7	9
30	R:R:C128	R:R:L210	64.7878	3.17	No	No	0	7	7
31	R:R:L210	R:R:L214	63.1117	5.54	No	No	0	7	7
32	R:R:L132	R:R:L214	40.0354	4.15	No	No	0	6	7
33	R:R:L132	R:R:W136	38.1612	11.39	No	No	0	6	5
34	R:R:R152	R:R:W136	36.2659	7	No	No	0	7	5
35	R:R:R148	R:R:R152	30.6506	4.26	Yes	No	0	8	7
36	R:R:R148	R:R:V70	16.7397	15.69	Yes	No	0	8	7
37	R:R:P150	R:R:V70	12.6379	3.53	No	No	0	5	7
38	L:L:?1	R:R:V117	54.0735	9.51	Yes	No	0	0	8
39	R:R:S168	R:R:V117	43.0976	4.85	No	No	0	8	8
40	R:R:L118	R:R:S168	37.8996	3	No	No	0	6	8
41	R:R:L118	R:R:W161	34.3635	5.69	No	Yes	0	6	9
42	R:R:L78	R:R:Y400	26.8246	3.52	No	Yes	2	9	9
43	R:R:L127	R:R:N396	10.0849	5.49	No	Yes	0	8	9
44	R:R:M84	R:R:W161	10	3.49	No	Yes	0	7	9
45	R:R:F112	R:R:W102	10.2263	7.02	No	Yes	0	6	9
46	R:R:C109	R:R:D110	24.9434	3.11	Yes	No	0	9	7
47	R:R:D110	R:R:R181	23.2532	4.76	No	No	0	7	4
48	R:R:I167	R:R:V117	12.1287	3.07	No	No	0	8	8
49	L:L:?1	R:R:T121	14.4696	5.88	Yes	No	0	0	8
50	R:R:I124	R:R:P207	10.5092	3.39	Yes	No	0	8	9
51	R:R:M211	R:R:Y215	44.5615	3.59	Yes	Yes	2	9	9
52	R:R:R134	R:R:Y215	24.7383	7.2	No	Yes	2	9	9
53	R:R:L214	R:R:Y135	24.7737	4.69	No	Yes	0	7	9
54	R:R:T139	R:R:Y135	12.6379	12.48	No	Yes	0	8	9
55	R:R:D140	R:R:T139	10.5658	4.34	No	No	0	7	8
56	R:R:I167	R:R:Y198	18.9109	6.04	No	No	0	8	5
57	R:R:I167	R:R:T121	11.075	4.56	No	No	0	8	8
58	R:R:I189	R:R:Y195	15.7992	3.63	Yes	Yes	0	6	8
59	R:R:P171	R:R:Y195	10.5799	12.52	No	Yes	0	7	8
60	L:L:?1	R:R:S199	14.2716	7.19	Yes	No	0	0	8
61	R:R:S199	R:R:Y195	12.7864	15.26	No	Yes	0	8	8
62	R:R:D192	R:R:Y195	14.0806	2.3	No	Yes	0	6	8
63	R:R:R176	R:R:R181	21.5488	10.66	No	No	0	6	4
64	R:R:D180	R:R:R176	18.0976	8.34	No	No	0	4	6
65	R:R:D180	R:R:T188	11.0255	5.78	No	No	0	4	5
66	L:L:?1	R:R:F362	19.9364	13.6	Yes	Yes	1	0	7
67	R:R:F204	R:R:F362	31.3296	19.29	Yes	Yes	0	8	7
68	R:R:F204	R:R:Y205	26.6902	5.16	Yes	Yes	0	8	7
69	R:R:F201	R:R:Y205	21.1528	14.44	No	Yes	7	5	7
70	R:R:F201	R:R:I197	19.4413	3.77	No	No	0	5	7
71	R:R:F370	R:R:I197	17.5601	5.02	No	No	0	5	7
72	R:R:F370	R:R:T196	11.8317	3.89	No	No	0	5	7
73	R:R:L347	R:R:Y215	24.8373	4.69	No	Yes	0	8	9
74	R:R:F219	R:R:L347	22.8147	3.65	Yes	No	0	6	8
75	R:R:F219	R:R:T343	12.6096	7.78	Yes	No	0	6	8
76	R:R:I399	R:R:Y400	15.587	2.42	No	Yes	0	8	9
77	L:L:?1	R:R:F361	12.6591	9.72	Yes	Yes	1	0	8
78	R:R:F361	R:R:N386	20.29	4.83	Yes	No	0	8	7
79	R:R:I385	R:R:N386	17.4328	2.83	No	No	0	6	7
80	R:R:L166	R:R:Y198	15.1556	1.17	No	No	0	5	5
81	R:R:L162	R:R:L166	11.3861	1.38	No	No	0	5	5
82	R:R:Q36	R:R:Y35	10.4738	1.13	No	No	0	4	4
83	R:R:R134	R:R:Y400	21.9873	6.17	No	Yes	2	9	9
84	R:R:F204	R:R:F354	14.3211	5.36	Yes	Yes	0	8	9
85	R:R:D82	R:R:L78	18.0976	5.43	Yes	No	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D116	19.49	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:V117	9.51	1	Yes	No	0	8	0	1
L:L:?1	R:R:C120	10.13	1	Yes	No	0	7	0	1
L:L:?1	R:R:T121	5.88	1	Yes	No	0	8	0	1
L:L:?1	R:R:I124	4.55	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:I189	4.55	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:S199	7.19	1	Yes	No	0	8	0	1
L:L:?1	R:R:A203	3.77	1	Yes	No	0	8	0	1
L:L:?1	R:R:W358	11.81	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F361	9.72	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F362	13.6	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Y390	3.74	1	Yes	Yes	0	8	0	1
R:R:L90	R:R:V85	2.98	0	Yes	No	8	8	2	2
R:R:C120	R:R:V85	3.42	1	No	No	7	8	1	2
R:R:D116	R:R:V89	4.38	1	Yes	No	8	8	1	2
R:R:V89	R:R:Y390	3.79	1	No	Yes	8	8	2	1
R:R:L90	R:R:Y390	5.86	0	Yes	Yes	8	8	2	1
R:R:I113	R:R:I189	2.94	6	No	Yes	7	6	2	1
R:R:C120	R:R:D116	3.11	1	No	Yes	7	8	1	1
R:R:D116	R:R:Y390	9.2	1	Yes	Yes	8	8	1	1
R:R:I167	R:R:V117	3.07	0	No	No	8	8	2	1
R:R:S168	R:R:V117	4.85	0	No	No	8	8	2	1
R:R:G164	R:R:T121	3.64	0	No	No	8	8	2	1
R:R:I167	R:R:T121	4.56	0	No	No	8	8	2	1
R:R:I124	R:R:P207	3.39	1	Yes	No	8	9	1	2
R:R:F354	R:R:I124	7.54	0	Yes	Yes	9	8	2	1
R:R:I124	R:R:W358	8.22	1	Yes	Yes	8	8	1	1
R:R:I189	R:R:K191	4.36	0	Yes	No	6	5	1	2
R:R:I189	R:R:Y195	3.63	0	Yes	Yes	6	8	1	2
R:R:S199	R:R:Y195	15.26	0	No	Yes	8	8	1	2
R:R:F204	R:R:F354	5.36	0	Yes	Yes	8	9	2	2
R:R:F204	R:R:F362	19.29	0	Yes	Yes	8	7	2	1
R:R:F361	R:R:W358	5.01	1	Yes	Yes	8	8	1	1
R:R:F362	R:R:W358	6.01	1	Yes	Yes	7	8	1	1
R:R:G389	R:R:W358	8.44	0	No	Yes	8	8	2	1
R:R:N392	R:R:W358	6.78	0	No	Yes	9	8	2	1
R:R:F361	R:R:F362	11.79	1	Yes	Yes	8	7	1	1
R:R:F361	R:R:N386	4.83	1	Yes	No	8	7	1	2
R:R:W387	R:R:Y390	8.68	0	Yes	Yes	8	8	2	1
R:R:A365	R:R:F361	2.77	0	No	Yes	8	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9DYD_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.94
Number of Linked Nodes	265
Number of Links	291
Number of Hubs	35
Number of Links mediated by Hubs	133
Number of Communities	8
Number of Nodes involved in Communities	49
Number of Links involved in Communities	68

Path Summary
Number Of Nodes in MetaPath	86
Number Of Links MetaPath	85
Number of Shortest Paths	40785
Length Of Smallest Path	3
Average Path Length	12.4176
Length of Longest Path	28
Minimum Path Strength	1.17
Average Path Strength	5.90827
Maximum Path Strength	17.46
Minimum Path Correlation	0.7
Average Path Correlation	0.938838
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5.88235
Average % Of Corr. Nodes	60.0162
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.5077
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • GABA-ergic synapse • glutamatergic synapse • cell body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • cation binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • signaling receptor binding • receptor-receptor interaction • tetrapyrrole binding • heme binding • electron transfer activity • transition metal ion binding • iron ion binding • metal ion binding • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • behavior • exploration behavior • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • regulation of tube diameter • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • gamma-aminobutyric acid signaling pathway • regulation of behavior • serotonin metabolic process • indole-containing compound metabolic process • serotonin receptor signaling pathway • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • monoatomic ion transport • serotonin secretion • regulation of monoatomic ion transport • regulation of serotonin secretion • serotonin transport • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • electron transport chain • generation of precursor metabolites and energy • periplasmic space
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1B
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1B
Name	1-deoxy-alpha-L-xylulofuranose-1,2-borate
Synonyms
Identifier
Formula	C5 H10 B O6
Molecular Weight	176.94
SMILES
PubChem	118797262
Formal Charge	-1
Total Atoms	22
Total Chiral Atoms	3
Total Bonds	23
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08908
Sequence	>9DYD_nogp_Chain_R Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E R S L Q N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N K W T L G Q V T C D L F I A L D V L C C T S S I H L C A I A L D R Y W A I T D P I D Y V N K R T P R R A A A L I S L T W L I G F L I S I P P M L G W R T P E D R S D P D A C T I S K D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C E S S C H M P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F Q N A F K K I I W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7E2X	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2X (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-	Gi1/β1/γ2	3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-		3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	8W8B	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-	Gi1/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8B (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8JSP	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-	Gi1/β1/γ2	3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSP (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-		3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8FY8	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-	Gi1/β1/γ1	2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FY8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-		2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-	Gi1/β1/γ1	2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-		2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-	Gi1/β1/γ1	2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-		2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-	Gi1/β1/γ1	2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-		2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gi1/β1/γ1	2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8JT6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-	Gi1/β1/γ2	3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8JT6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-		3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8PJK	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-	Gi1/β1/γ1	2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PJK (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-		2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gi1/β1/γ1	2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	9GL2	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gs/β1/γ2	3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9GL2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9DYF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-	Gi1/β1/γ2	2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-		2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-	Go/β1/γ2	2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-		2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Go/β1/γ2	2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851

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Download 9DYD_nogp.zip

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