psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y96	9.2	Yes	No	1	0	6
2	L:L:?1	R:R:W102	5.21	Yes	Yes	1	0	9
3	L:L:?1	R:R:D116	16.86	Yes	Yes	1	0	8
4	L:L:?1	R:R:V117	8.77	Yes	No	0	0	8
5	L:L:?1	R:R:C120	5.19	Yes	No	1	0	7
6	L:L:?1	R:R:F361	16.72	Yes	Yes	1	0	8
7	L:L:?1	R:R:F362	7.96	Yes	Yes	1	0	7
8	L:L:?1	R:R:N386	8.08	Yes	No	1	0	7
9	L:L:?1	R:R:Y390	10.73	Yes	Yes	1	0	8
10	R:R:Q36	R:R:T39	4.25	No	No	0	4	5
11	R:R:A94	R:R:L43	4.73	No	No	0	7	7
12	R:R:L43	R:R:W387	17.08	No	Yes	0	7	8
13	R:R:G44	R:R:I47	3.53	No	No	0	4	7
14	R:R:I47	R:R:L90	4.28	No	No	0	7	8
15	R:R:A50	R:R:S86	3.42	No	No	0	8	8
16	R:R:G53	R:R:Y402	4.35	No	Yes	0	9	6
17	R:R:D82	R:R:N54	6.73	Yes	No	0	9	9
18	R:R:L83	R:R:N54	4.12	No	No	0	8	9
19	R:R:N54	R:R:P397	9.77	No	No	0	9	9
20	R:R:C56	R:R:Y402	4.03	No	Yes	0	8	6
21	R:R:A79	R:R:V57	3.39	No	Yes	0	9	9
22	R:R:A401	R:R:V57	5.09	No	Yes	2	8	9
23	R:R:V57	R:R:Y402	3.79	Yes	Yes	0	9	6
24	R:R:F407	R:R:V57	3.93	Yes	Yes	2	8	9
25	R:R:V58	R:R:V80	6.41	No	No	0	7	7
26	R:R:A60	R:R:F411	5.55	No	No	0	8	8
27	R:R:F407	R:R:I61	6.28	Yes	No	0	8	8
28	R:R:E64	R:R:L63	3.98	Yes	No	4	7	6
29	R:R:I414	R:R:L63	5.71	No	No	4	7	6
30	R:R:A410	R:R:E64	4.53	No	Yes	0	8	7
31	R:R:E64	R:R:K413	8.1	Yes	No	0	7	6
32	R:R:E64	R:R:I414	4.1	Yes	No	4	7	7
33	R:R:Q68	R:R:R65	5.84	No	No	0	8	7
34	R:R:L67	R:R:N72	8.24	Yes	Yes	2	8	9
35	R:R:F407	R:R:L67	6.09	Yes	Yes	2	8	8
36	R:R:Q68	R:R:Y73	7.89	No	No	0	8	6
37	R:R:N69	R:R:N72	6.81	No	Yes	0	8	9
38	R:R:D133	R:R:V70	4.38	No	Yes	5	9	7
39	R:R:R148	R:R:V70	15.69	Yes	Yes	5	8	7
40	R:R:P150	R:R:V70	3.53	No	Yes	0	5	7
41	R:R:A153	R:R:V70	5.09	No	Yes	0	7	7
42	R:R:F407	R:R:N72	7.25	Yes	Yes	2	8	9
43	R:R:P150	R:R:Y73	5.56	No	No	0	5	6
44	R:R:D133	R:R:L74	5.43	No	No	0	9	8
45	R:R:L156	R:R:L74	4.15	No	No	0	6	8
46	R:R:H126	R:R:S77	5.58	Yes	No	1	8	9
47	R:R:I157	R:R:S77	12.39	No	No	1	8	9
48	R:R:D82	R:R:L78	8.14	Yes	Yes	1	9	9
49	R:R:H126	R:R:L78	7.71	Yes	Yes	1	8	9
50	R:R:L127	R:R:L78	5.54	Yes	Yes	1	8	9
51	R:R:I130	R:R:L78	4.28	No	Yes	1	9	9
52	R:R:L78	R:R:N396	12.36	Yes	Yes	1	9	9
53	R:R:L78	R:R:Y400	4.69	Yes	Yes	1	9	9
54	R:R:S122	R:R:T81	7.99	No	No	1	8	9
55	R:R:H126	R:R:T81	10.95	Yes	No	1	8	9
56	R:R:T81	R:R:W161	8.49	No	Yes	1	9	9
57	R:R:D82	R:R:S123	5.89	Yes	No	0	9	9
58	R:R:D82	R:R:S393	4.42	Yes	No	0	9	9
59	R:R:D82	R:R:N396	8.08	Yes	Yes	1	9	9
60	R:R:M84	R:R:W161	5.82	No	Yes	0	7	9
61	R:R:C119	R:R:V85	3.42	No	No	0	7	8
62	R:R:S393	R:R:V85	4.85	No	No	0	9	8
63	R:R:L88	R:R:V87	4.47	No	No	0	6	6
64	R:R:L115	R:R:L88	5.54	No	No	0	5	6
65	R:R:D116	R:R:V89	11.69	Yes	No	1	8	8
66	R:R:V89	R:R:Y390	3.79	No	Yes	1	8	8
67	R:R:L90	R:R:W387	4.56	No	Yes	1	8	8
68	R:R:L90	R:R:Y390	9.38	No	Yes	1	8	8
69	R:R:F112	R:R:M92	8.71	No	No	0	6	6
70	R:R:A93	R:R:Y390	5.34	No	Yes	0	7	8
71	R:R:W102	R:R:Y96	5.79	Yes	No	1	9	6
72	R:R:A383	R:R:Q97	4.55	No	No	0	6	7
73	R:R:Q97	R:R:W387	5.48	No	Yes	0	7	8
74	R:R:K101	R:R:L99	8.46	No	No	0	5	5
75	R:R:K101	R:R:T103	7.51	No	No	0	5	5
76	R:R:D185	R:R:K101	8.3	No	No	0	4	5
77	R:R:L104	R:R:W102	12.53	No	Yes	0	7	9
78	R:R:C109	R:R:W102	9.14	No	Yes	1	9	9
79	R:R:F112	R:R:W102	5.01	No	Yes	0	6	9
80	R:R:C187	R:R:W102	16.98	No	Yes	1	9	9
81	R:R:L104	R:R:T108	5.9	No	No	0	7	6
82	R:R:C109	R:R:I113	3.27	No	No	1	9	7
83	R:R:C109	R:R:C187	7.28	No	No	1	9	9
84	R:R:D110	R:R:R176	7.15	No	No	0	7	6
85	R:R:D110	R:R:R181	8.34	No	No	0	7	4
86	R:R:C187	R:R:I113	3.27	No	No	1	9	7
87	R:R:I113	R:R:I189	4.42	No	No	0	7	6
88	R:R:C120	R:R:D116	4.67	No	Yes	1	7	8
89	R:R:D116	R:R:Y390	11.49	Yes	Yes	1	8	8
90	R:R:L118	R:R:W161	6.83	No	Yes	0	6	9
91	R:R:F165	R:R:L118	12.18	No	No	0	5	6
92	R:R:C120	R:R:W358	5.22	No	Yes	1	7	8
93	R:R:G164	R:R:T121	3.64	No	No	0	8	8
94	R:R:I167	R:R:T121	7.6	No	No	0	8	8
95	R:R:A203	R:R:T121	5.03	No	No	0	8	8
96	R:R:H126	R:R:S122	8.37	Yes	No	1	8	8
97	R:R:S122	R:R:W161	18.53	No	Yes	1	8	9
98	R:R:I124	R:R:P207	3.39	No	Yes	1	8	9
99	R:R:F354	R:R:I124	5.02	Yes	No	1	9	8
100	R:R:I124	R:R:W358	10.57	No	Yes	1	8	8
101	R:R:C128	R:R:W125	5.22	No	Yes	1	7	7
102	R:R:T160	R:R:W125	3.64	No	Yes	0	8	7
103	R:R:I163	R:R:W125	21.14	No	Yes	0	5	7
104	R:R:P207	R:R:W125	17.57	Yes	Yes	1	9	7
105	R:R:H126	R:R:I157	6.63	Yes	No	1	8	8
106	R:R:H126	R:R:T160	10.95	Yes	No	0	8	8
107	R:R:H126	R:R:W161	5.29	Yes	Yes	1	8	9
108	R:R:F354	R:R:L127	4.87	Yes	Yes	1	9	8
109	R:R:L127	R:R:N396	9.61	Yes	Yes	1	8	9
110	R:R:L127	R:R:Y400	7.03	Yes	Yes	1	8	9
111	R:R:C128	R:R:P207	3.77	No	Yes	1	7	9
112	R:R:C128	R:R:M211	4.86	No	No	0	7	9
113	R:R:A129	R:R:L156	4.73	No	No	0	8	6
114	R:R:I130	R:R:R134	7.52	No	No	1	9	9
115	R:R:I130	R:R:Y400	7.25	No	Yes	1	9	9
116	R:R:A131	R:R:Y215	6.67	No	Yes	0	9	9
117	R:R:L132	R:R:W136	18.22	No	No	0	6	5
118	R:R:L132	R:R:L214	6.92	No	No	0	6	7
119	R:R:D133	R:R:R148	11.91	No	Yes	5	9	8
120	R:R:R134	R:R:Y215	8.23	No	Yes	0	9	9
121	R:R:R134	R:R:Y400	6.17	No	Yes	1	9	9
122	R:R:W136	R:R:Y135	3.86	No	Yes	0	5	9
123	R:R:T139	R:R:Y135	14.98	No	Yes	0	8	9
124	R:R:L214	R:R:Y135	7.03	No	Yes	0	7	9
125	R:R:R217	R:R:Y135	12.35	No	Yes	0	7	9
126	R:R:I218	R:R:Y135	3.63	No	Yes	0	9	9
127	R:R:R152	R:R:W136	6	No	No	0	7	5
128	R:R:D140	R:R:D143	7.98	No	No	0	7	6
129	R:R:D143	R:R:K147	12.44	No	No	0	6	5
130	R:R:D143	R:R:R152	11.91	No	No	0	6	7
131	R:R:R148	R:R:Y144	14.4	Yes	No	0	8	8
132	R:R:R148	R:R:R152	5.33	Yes	No	0	8	7
133	R:R:P150	R:R:T149	3.5	No	No	0	5	8
134	R:R:R151	R:R:T149	3.88	No	No	0	6	8
135	R:R:L162	R:R:L166	5.54	No	No	0	5	5
136	R:R:I167	R:R:Y198	6.04	No	Yes	0	8	5
137	R:R:I169	R:R:P170	5.08	No	Yes	0	6	8
138	R:R:P170	R:R:P171	5.84	Yes	No	3	8	7
139	R:R:P170	R:R:W175	6.76	Yes	Yes	3	8	6
140	R:R:P170	R:R:Y195	4.17	Yes	Yes	3	8	8
141	R:R:P170	R:R:Y198	8.34	Yes	Yes	3	8	5
142	R:R:P171	R:R:Y195	13.91	No	Yes	3	7	8
143	R:R:W175	R:R:Y195	7.72	Yes	Yes	3	6	8
144	R:R:W175	R:R:Y198	7.72	Yes	Yes	3	6	5
145	R:R:D180	R:R:R176	16.68	No	No	0	4	6
146	R:R:R176	R:R:S190	7.91	No	No	0	6	6
147	R:R:P178	R:R:T177	3.5	No	No	0	5	5
148	R:R:E179	R:R:S182	4.31	No	No	0	3	3
149	R:R:D180	R:R:R181	4.76	No	No	0	4	4
150	R:R:D183	R:R:P184	4.83	No	No	0	1	1
151	R:R:I189	R:R:K191	4.36	No	No	0	6	5
152	R:R:I189	R:R:Y195	3.63	No	Yes	0	6	8
153	R:R:K191	R:R:P369	5.02	No	No	0	5	7
154	R:R:F370	R:R:H193	18.1	No	No	0	5	4
155	R:R:E372	R:R:H193	4.92	No	No	0	3	4
156	R:R:S199	R:R:Y195	10.17	No	Yes	0	8	8
157	R:R:P369	R:R:T196	12.24	No	No	0	7	7
158	R:R:F370	R:R:T196	3.89	No	No	0	5	7
159	R:R:F370	R:R:I197	5.02	No	No	0	5	7
160	R:R:F362	R:R:T200	5.19	Yes	No	0	7	7
161	R:R:L366	R:R:T200	8.84	No	No	0	7	7
162	R:R:F201	R:R:Y205	7.22	No	No	1	5	7
163	R:R:F201	R:R:L366	6.09	No	No	1	5	7
164	R:R:G202	R:R:I206	3.53	No	No	0	5	6
165	R:R:F204	R:R:Y205	9.28	Yes	No	1	8	7
166	R:R:F204	R:R:L208	8.53	Yes	Yes	1	8	7
167	R:R:F204	R:R:F354	9.65	Yes	Yes	1	8	9
168	R:R:F204	R:R:L359	7.31	Yes	Yes	0	8	7
169	R:R:F204	R:R:F362	20.36	Yes	Yes	1	8	7
170	R:R:L366	R:R:Y205	4.69	No	No	1	7	7
171	R:R:I206	R:R:P207	3.39	No	Yes	0	6	9
172	R:R:L208	R:R:L212	4.15	Yes	No	0	7	6
173	R:R:F354	R:R:L208	3.65	Yes	Yes	1	9	7
174	R:R:I355	R:R:L208	5.71	Yes	Yes	0	7	7
175	R:R:L210	R:R:L214	5.54	No	No	0	7	7
176	R:R:M211	R:R:M351	5.78	No	No	0	9	8
177	R:R:F354	R:R:M211	6.22	Yes	No	0	9	9
178	R:R:L212	R:R:M351	4.24	No	No	0	6	8
179	R:R:R217	R:R:V213	5.23	No	No	0	7	5
180	R:R:I218	R:R:Y215	3.63	No	Yes	0	9	9
181	R:R:L347	R:R:Y215	4.69	No	Yes	0	8	9
182	R:R:I350	R:R:Y215	8.46	No	Yes	0	8	9
183	R:R:M351	R:R:Y215	3.59	No	Yes	0	8	9
184	R:R:F219	R:R:R223	7.48	Yes	No	0	6	7
185	R:R:F219	R:R:L347	3.65	Yes	No	0	6	8
186	R:R:A222	R:R:T343	3.36	No	No	0	8	8
187	R:R:R223	R:R:R227	4.26	No	No	0	7	6
188	R:R:F224	R:R:R225	6.41	No	No	0	6	7
189	R:R:F224	R:R:K228	6.2	No	No	0	6	5
190	R:R:I226	R:R:R339	6.26	No	No	0	6	7
191	R:R:E340	R:R:I226	6.83	No	No	0	8	6
192	R:R:E340	R:R:R227	11.63	No	No	0	8	6
193	R:R:E326	R:R:K324	16.2	No	No	0	3	1
194	R:R:K324	R:R:R327	4.95	No	No	0	1	3
195	R:R:E330	R:R:R333	6.98	No	No	0	4	4
196	R:R:K334	R:R:R333	6.19	No	No	0	5	4
197	R:R:L337	R:R:R333	7.29	No	No	0	5	4
198	R:R:M335	R:R:R339	8.69	No	No	0	4	7
199	R:R:I349	R:R:I399	4.42	No	Yes	0	7	8
200	R:R:I350	R:R:Y400	4.84	No	Yes	0	8	9
201	R:R:I399	R:R:T353	6.08	Yes	No	0	8	7
202	R:R:F354	R:R:W358	4.01	Yes	Yes	1	9	8
203	R:R:I355	R:R:L359	8.56	Yes	Yes	0	7	7
204	R:R:C357	R:R:N392	9.45	No	No	0	8	9
205	R:R:F361	R:R:W358	8.02	Yes	Yes	1	8	8
206	R:R:F362	R:R:W358	9.02	Yes	Yes	1	7	8
207	R:R:G389	R:R:W358	8.44	No	Yes	0	8	8
208	R:R:N392	R:R:W358	9.04	No	Yes	0	9	8
209	R:R:L359	R:R:P360	3.28	Yes	No	0	7	9
210	R:R:I363	R:R:L359	7.14	No	Yes	0	7	7
211	R:R:I385	R:R:P360	3.39	No	No	0	6	9
212	R:R:F361	R:R:F362	13.93	Yes	Yes	1	8	7
213	R:R:F361	R:R:N386	4.83	Yes	No	1	8	7
214	R:R:M377	R:R:V364	7.61	Yes	No	0	4	6
215	R:R:L368	R:R:M377	4.24	No	Yes	0	4	4
216	R:R:C371	R:R:C375	5.46	No	No	0	5	4
217	R:R:M377	R:R:P378	3.35	Yes	No	6	4	7
218	R:R:L381	R:R:M377	4.24	No	Yes	6	6	4
219	R:R:L381	R:R:P378	6.57	No	No	6	6	7
220	R:R:I384	R:R:L380	7.14	No	No	0	4	3
221	R:R:I385	R:R:L381	7.14	No	No	0	6	6
222	R:R:W387	R:R:Y390	8.68	Yes	Yes	1	8	8
223	R:R:N392	R:R:N396	12.26	No	Yes	0	9	9
224	R:R:N396	R:R:Y400	3.49	Yes	Yes	1	9	9
225	R:R:F403	R:R:V398	3.93	No	No	0	8	6
226	R:R:I399	R:R:Y400	7.25	Yes	Yes	0	8	9
227	R:R:F403	R:R:I399	3.77	No	Yes	0	8	8
228	R:R:A401	R:R:F407	8.32	No	Yes	2	8	8
229	R:R:F411	R:R:Y402	9.28	No	Yes	0	8	6
230	R:R:F407	R:R:N404	10.87	Yes	No	0	8	9
231	R:R:K405	R:R:Q408	9.49	No	No	0	6	9
232	R:R:F407	R:R:F411	5.36	Yes	No	0	8	8
233	R:R:K412	R:R:N409	4.2	No	No	0	6	6
234	R:R:S393	R:R:S86	3.26	No	No	0	9	8
235	R:R:S40	R:R:V37	3.23	No	No	0	5	5
236	R:R:S168	R:R:V117	3.23	No	No	0	8	8
237	R:R:A114	R:R:M172	3.22	No	No	0	7	6
238	R:R:D140	R:R:P141	3.22	No	No	0	7	8
239	R:R:V51	R:R:V87	3.21	No	No	0	7	6
240	R:R:R217	R:R:R220	3.2	No	No	0	7	5
241	R:R:T39	R:R:V98	3.17	No	No	0	5	6
242	R:R:C56	R:R:L52	3.17	No	No	0	8	4
243	R:R:C119	R:R:L115	3.17	No	No	0	7	5
244	R:R:A50	R:R:L394	3.15	No	No	0	8	7
245	R:R:A410	R:R:L67	3.15	No	Yes	0	8	8
246	R:R:A186	R:R:D183	3.09	No	No	0	4	1
247	R:R:L46	R:R:S391	3	No	No	0	7	5
248	R:R:L67	R:R:S66	3	Yes	No	0	8	6
249	R:R:K191	R:R:T188	3	No	No	0	5	5
250	R:R:N146	R:R:V145	2.96	No	No	0	5	6
251	R:R:L43	R:R:T39	2.95	No	No	0	7	5
252	R:R:L347	R:R:T343	2.95	No	No	0	8	8
253	R:R:L395	R:R:T353	2.95	No	No	0	6	7
254	R:R:I169	R:R:M172	2.92	No	No	0	6	6
255	R:R:I349	R:R:K345	2.91	No	No	0	7	7
256	R:R:D192	R:R:T177	2.89	No	No	0	6	5
257	R:R:I355	R:R:L356	2.85	Yes	No	0	7	5
258	R:R:I75	R:R:N72	2.83	No	Yes	0	8	9
259	R:R:I142	R:R:N146	2.83	No	No	0	6	5
260	R:R:E179	R:R:T177	2.82	No	No	0	3	5
261	R:R:P397	R:R:Y402	2.78	No	Yes	0	9	6
262	R:R:L95	R:R:L99	2.77	No	No	0	6	5
263	R:R:A365	R:R:F361	2.77	No	Yes	0	8	8
264	R:R:A137	R:R:Y144	2.67	No	No	0	8	8
265	R:R:F219	R:R:V344	2.62	Yes	No	0	6	8
266	R:R:S190	R:R:Y195	2.54	No	Yes	0	6	8
267	R:R:F48	R:R:L52	2.44	No	No	0	4	4
268	R:R:Q106	R:R:R181	2.34	No	No	0	4	4
269	R:R:L46	R:R:W387	2.28	No	Yes	0	7	8
270	R:R:A79	R:R:G76	1.95	No	No	0	9	6
271	R:R:G352	R:R:I355	1.76	No	Yes	0	6	7
272	R:R:G382	R:R:M377	1.75	No	Yes	0	4	4
273	R:R:C375	R:R:S374	1.72	No	No	0	4	5
274	R:R:C371	R:R:V367	1.71	No	No	0	5	6
275	R:R:G389	R:R:L388	1.71	No	No	0	8	8
276	R:R:A79	R:R:V58	1.7	No	No	0	9	7
277	R:R:C49	R:R:T45	1.69	No	No	0	5	4
278	R:R:I47	R:R:P91	1.69	No	No	0	7	9
279	R:R:A221	R:R:T139	1.68	No	No	0	6	8
280	R:R:D192	R:R:G194	1.68	No	No	0	6	5
281	R:R:S373	R:R:S374	1.63	No	No	0	3	5
282	R:R:S40	R:R:V98	1.62	No	No	0	5	6
283	R:R:A221	R:R:I138	1.62	No	No	0	6	9
284	R:R:A336	R:R:I226	1.62	No	No	0	5	6
285	R:R:C49	R:R:L394	1.59	No	No	0	5	7
286	R:R:T108	R:R:V107	1.59	No	No	0	6	4
287	R:R:G194	R:R:H193	1.59	No	No	0	5	4
288	R:R:A55	R:R:L83	1.58	No	No	0	5	8
289	R:R:A71	R:R:N69	1.56	No	No	0	8	8
290	R:R:I350	R:R:T346	1.52	No	No	0	8	8
291	R:R:F219	R:R:G216	1.51	Yes	No	0	6	3
292	R:R:L41	R:R:S40	1.5	No	No	0	4	5
293	R:R:L159	R:R:S158	1.5	No	No	0	3	5
294	R:R:K342	R:R:T346	1.5	No	No	0	8	8
295	R:R:L99	R:R:V98	1.49	No	No	0	5	6
296	R:R:I414	R:R:I415	1.47	No	No	0	7	7
297	R:R:I38	R:R:L42	1.43	No	No	0	3	5
298	R:R:I384	R:R:L388	1.43	No	No	0	4	8
299	R:R:G174	R:R:W175	1.41	No	Yes	0	5	6
300	R:R:D140	R:R:I142	1.4	No	No	0	7	6
301	R:R:K147	R:R:N146	1.4	No	No	0	5	5
302	R:R:K405	R:R:N409	1.4	No	No	0	6	6
303	R:R:L41	R:R:L42	1.38	No	No	0	4	5
304	R:R:L159	R:R:L162	1.38	No	No	0	3	5
305	R:R:D406	R:R:L67	1.36	No	Yes	0	7	8
306	R:R:A186	R:R:Y96	1.33	No	No	0	4	6
307	R:R:D183	R:R:D185	1.33	No	No	0	1	4
308	R:R:N100	R:R:Q36	1.32	No	No	0	5	4
309	R:R:L166	R:R:Y198	1.17	No	Yes	0	5	5
310	R:R:Q36	R:R:Y35	1.13	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.85778	9	1	0
2	R:R:V57	4.05	4	2	9
3	R:R:E64	5.1775	4	4	7
4	R:R:L67	4.368	5	2	8
5	R:R:V70	7.1725	4	5	7
6	R:R:N72	6.2825	4	2	9
7	R:R:L78	7.12	6	1	9
8	R:R:D82	6.652	5	1	9
9	R:R:W102	9.11	6	1	9
10	R:R:D116	11.1775	4	1	8
11	R:R:W125	11.8925	4	1	7
12	R:R:H126	7.92571	7	1	8
13	R:R:L127	6.7625	4	1	8
14	R:R:Y135	8.37	5	0	9
15	R:R:R148	11.8325	4	5	8
16	R:R:W161	8.992	5	1	9
17	R:R:P170	6.038	5	3	8
18	R:R:W175	5.9025	4	3	6
19	R:R:Y195	7.02333	6	3	8
20	R:R:Y198	5.8175	4	3	5
21	R:R:F204	11.026	5	1	8
22	R:R:P207	7.03	4	1	9
23	R:R:L208	5.51	4	1	7
24	R:R:Y215	5.87833	6	0	9
25	R:R:F219	3.815	4	0	6
26	R:R:F354	5.57	6	1	9
27	R:R:I355	4.72	4	0	7
28	R:R:W358	7.76	7	1	8
29	R:R:L359	6.5725	4	0	7
30	R:R:F361	9.254	5	1	8
31	R:R:F362	11.292	5	1	7
32	R:R:M377	4.238	5	6	4
33	R:R:W387	7.616	5	1	8
34	R:R:Y390	8.235	6	1	8
35	R:R:N396	9.16	5	1	9
36	R:R:I399	5.38	4	0	8
37	R:R:Y400	5.81714	7	1	9
38	R:R:Y402	4.846	5	0	6
39	R:R:F407	6.87143	7	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y390	25.1316	10.73	Yes	Yes	1	0	8
2	R:R:W387	R:R:Y390	23.3063	8.68	Yes	Yes	1	8	8
3	R:R:L43	R:R:W387	17.309	17.08	No	Yes	0	7	8
4	R:R:L43	R:R:T39	14.8724	2.95	No	No	0	7	5
5	L:L:?1	R:R:C120	33.2857	5.19	Yes	No	1	0	7
6	R:R:C120	R:R:W358	39.4444	5.22	No	Yes	1	7	8
7	R:R:N392	R:R:W358	53.5514	9.04	No	Yes	0	9	8
8	R:R:N392	R:R:N396	52.7355	12.26	No	Yes	0	9	9
9	R:R:D82	R:R:N396	48.9579	8.08	Yes	Yes	1	9	9
10	R:R:D82	R:R:S393	13.2221	4.42	Yes	No	0	9	9
11	L:L:?1	R:R:F361	33.4447	16.72	Yes	Yes	1	0	8
12	R:R:F361	R:R:W358	33.7947	8.02	Yes	Yes	1	8	8
13	L:L:?1	R:R:F362	61.6032	7.96	Yes	Yes	1	0	7
14	R:R:F362	R:R:W358	33.7861	9.02	Yes	Yes	1	7	8
15	R:R:D82	R:R:N54	51.9356	6.73	Yes	No	0	9	9
16	R:R:N54	R:R:P397	48.9259	9.77	No	No	0	9	9
17	R:R:P397	R:R:Y402	47.9177	2.78	No	Yes	0	9	6
18	R:R:V57	R:R:Y402	23.5737	3.79	Yes	Yes	0	9	6
19	R:R:F407	R:R:V57	17.2461	3.93	Yes	Yes	2	8	9
20	R:R:F411	R:R:Y402	19.2896	9.28	No	Yes	0	8	6
21	R:R:F407	R:R:F411	17.1894	5.36	Yes	No	0	8	8
22	R:R:F407	R:R:L67	19.3993	6.09	Yes	Yes	2	8	8
23	R:R:A410	R:R:L67	12.9842	3.15	No	Yes	0	8	8
24	R:R:A410	R:R:E64	10.8261	4.53	No	Yes	0	8	7
25	R:R:F354	R:R:W358	47.3323	4.01	Yes	Yes	1	9	8
26	R:R:F354	R:R:M211	43.3292	6.22	Yes	No	0	9	9
27	R:R:M211	R:R:M351	41.8724	5.78	No	No	0	9	8
28	R:R:M351	R:R:Y215	52.5938	3.59	No	Yes	0	8	9
29	R:R:I218	R:R:Y215	54.1676	3.63	No	Yes	0	9	9
30	R:R:I218	R:R:Y135	52.7035	3.63	No	Yes	0	9	9
31	R:R:W136	R:R:Y135	37.8927	3.86	No	Yes	0	5	9
32	R:R:R152	R:R:W136	34.968	6	No	No	0	7	5
33	R:R:R148	R:R:R152	23.0154	5.33	Yes	No	0	8	7
34	R:R:R148	R:R:V70	12.3039	15.69	Yes	Yes	5	8	7
35	R:R:F204	R:R:F362	28.357	20.36	Yes	Yes	1	8	7
36	R:R:F204	R:R:F354	18.5501	9.65	Yes	Yes	1	8	9
37	R:R:F204	R:R:L208	11.4239	8.53	Yes	Yes	1	8	7
38	R:R:L208	R:R:L212	11.7591	4.15	Yes	No	0	7	6
39	R:R:L212	R:R:M351	11.4301	4.24	No	No	0	6	8
40	R:R:F354	R:R:L127	24.3563	4.87	Yes	Yes	1	9	8
41	R:R:L127	R:R:L78	11.0467	5.54	Yes	Yes	1	8	9
42	R:R:H126	R:R:L78	16.0038	7.71	Yes	Yes	1	8	9
43	R:R:L127	R:R:Y400	10.6031	7.03	Yes	Yes	1	8	9
44	R:R:N396	R:R:Y400	17.0489	3.49	Yes	Yes	1	9	9
45	L:L:?1	R:R:W102	100	5.21	Yes	Yes	1	0	9
46	R:R:C109	R:R:W102	48.2295	9.14	No	Yes	1	9	9
47	R:R:C187	R:R:W102	48.2591	16.98	No	Yes	1	9	9
48	R:R:C109	R:R:I113	47.3631	3.27	No	No	1	9	7
49	R:R:C187	R:R:I113	47.3927	3.27	No	No	1	9	7
50	R:R:I113	R:R:I189	92.9527	4.42	No	No	0	7	6
51	R:R:I189	R:R:Y195	65.6938	3.63	No	Yes	0	6	8
52	R:R:S190	R:R:Y195	15.3074	2.54	No	Yes	0	6	8
53	R:R:R176	R:R:S190	13.402	7.91	No	No	0	6	6
54	R:R:P170	R:R:Y195	24.5757	4.17	Yes	Yes	3	8	8
55	R:R:P170	R:R:Y198	17.0588	8.34	Yes	Yes	3	8	5
56	R:R:I167	R:R:Y198	15.1374	6.04	No	Yes	0	8	5
57	R:R:I167	R:R:T121	11.3401	7.6	No	No	0	8	8
58	R:R:W175	R:R:Y195	20.7932	7.72	Yes	Yes	3	6	8
59	R:R:W175	R:R:Y198	17.0268	7.72	Yes	Yes	3	6	5
60	R:R:R134	R:R:Y400	11.0739	6.17	No	Yes	1	9	9
61	R:R:D143	R:R:R152	10.8076	11.91	No	No	0	6	7
62	R:R:L166	R:R:Y198	15.2027	1.17	No	Yes	0	5	5
63	R:R:L162	R:R:L166	11.4054	5.54	No	No	0	5	5
64	R:R:I189	R:R:K191	26.6919	4.36	No	No	0	6	5
65	R:R:K191	R:R:P369	22.9082	5.02	No	No	0	5	7
66	R:R:P369	R:R:T196	21.0126	12.24	No	No	0	7	7
67	R:R:F370	R:R:T196	19.1146	3.89	No	No	0	5	7
68	R:R:F370	R:R:H193	15.3111	18.1	No	No	0	5	4
69	R:R:G194	R:R:H193	11.4978	1.59	No	No	0	5	4
70	R:R:L347	R:R:Y215	19.8676	4.69	No	Yes	0	8	9
71	R:R:I350	R:R:Y400	14.2919	4.84	No	Yes	0	8	9
72	R:R:F219	R:R:L347	15.2976	3.65	Yes	No	0	6	8
73	R:R:F219	R:R:R223	10.7053	7.48	Yes	No	0	6	7
74	R:R:I399	R:R:Y400	11.9736	7.25	Yes	Yes	0	8	9
75	R:R:D82	R:R:L78	16.6854	8.14	Yes	Yes	1	9	9
76	R:R:R134	R:R:Y215	14.4373	8.23	No	Yes	0	9	9
77	R:R:L78	R:R:Y400	10.5994	4.69	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y96	9.2	1	Yes	No	0	6	0	1
L:L:?1	R:R:W102	5.21	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:D116	16.86	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:V117	8.77	1	Yes	No	0	8	0	1
L:L:?1	R:R:C120	5.19	1	Yes	No	0	7	0	1
L:L:?1	R:R:F361	16.72	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F362	7.96	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N386	8.08	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y390	10.73	1	Yes	Yes	0	8	0	1
R:R:D116	R:R:V89	11.69	1	Yes	No	8	8	1	2
R:R:V89	R:R:Y390	3.79	1	No	Yes	8	8	2	1
R:R:L90	R:R:W387	4.56	1	No	Yes	8	8	2	2
R:R:L90	R:R:Y390	9.38	1	No	Yes	8	8	2	1
R:R:A93	R:R:Y390	5.34	0	No	Yes	7	8	2	1
R:R:W102	R:R:Y96	5.79	1	Yes	No	9	6	1	1
R:R:L104	R:R:W102	12.53	0	No	Yes	7	9	2	1
R:R:C109	R:R:W102	9.14	1	No	Yes	9	9	2	1
R:R:F112	R:R:W102	5.01	0	No	Yes	6	9	2	1
R:R:C187	R:R:W102	16.98	1	No	Yes	9	9	2	1
R:R:C109	R:R:C187	7.28	1	No	No	9	9	2	2
R:R:C120	R:R:D116	4.67	1	No	Yes	7	8	1	1
R:R:D116	R:R:Y390	11.49	1	Yes	Yes	8	8	1	1
R:R:C120	R:R:W358	5.22	1	No	Yes	7	8	1	2
R:R:F362	R:R:T200	5.19	1	Yes	No	7	7	1	2
R:R:F204	R:R:F362	20.36	1	Yes	Yes	8	7	2	1
R:R:F361	R:R:W358	8.02	1	Yes	Yes	8	8	1	2
R:R:F362	R:R:W358	9.02	1	Yes	Yes	7	8	1	2
R:R:F361	R:R:F362	13.93	1	Yes	Yes	8	7	1	1
R:R:F361	R:R:N386	4.83	1	Yes	No	8	7	1	1
R:R:W387	R:R:Y390	8.68	1	Yes	Yes	8	8	2	1
R:R:S168	R:R:V117	3.23	0	No	No	8	8	2	1
R:R:A365	R:R:F361	2.77	0	No	Yes	8	8	2	1
R:R:A186	R:R:Y96	1.33	0	No	No	4	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8FYX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.27
Number of Linked Nodes	269
Number of Links	310
Number of Hubs	39
Number of Links mediated by Hubs	155
Number of Communities	6
Number of Nodes involved in Communities	58
Number of Links involved in Communities	86

Path Summary
Number Of Nodes in MetaPath	78
Number Of Links MetaPath	77
Number of Shortest Paths	151840
Length Of Smallest Path	3
Average Path Length	15.7266
Length of Longest Path	31
Minimum Path Strength	1.225
Average Path Strength	6.55253
Maximum Path Strength	19.355
Minimum Path Correlation	0.7
Average Path Correlation	0.939108
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	50.3675
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.6608
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • serotonin binding • amine binding • heterocyclic compound binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • signaling receptor binding • receptor-receptor interaction • electron transport chain • metabolic process • generation of precursor metabolites and energy • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • behavior • exploration behavior • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • regulation of tube diameter • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • gamma-aminobutyric acid signaling pathway • regulation of behavior • ammonium ion metabolic process • serotonin metabolic process • indole-containing compound metabolic process • primary amino compound metabolic process • serotonin receptor signaling pathway • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • monoatomic ion transport • serotonin secretion • regulation of monoatomic ion transport • regulation of serotonin secretion • serotonin transport • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • periplasmic space • somatodendritic compartment • dendrite • dendritic tree
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	YLX
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	YLX
Name	Buspirone
Synonyms	Buspironum
Identifier
Formula	C21 H31 N5 O2
Molecular Weight	385.503
SMILES
PubChem	2477
Formal Charge	0
Total Atoms	59
Total Chiral Atoms	0
Total Bonds	62
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08908
Sequence	>8FYX_nogp_Chain_R Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E R S L Q N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N K W T L G Q V T C D L F I A L D V L C C T S S I W H L C A I A L D R Y W A I T D P I D Y V N K R T P R R A A A L I S L T W L I G F L I S I P P M L G W R T P E D R S D P D A C T I S K D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C E S S C H M P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F Q N A F K K I I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8PKM	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	t7m	Gi1/β1/γ1	2.9	2024-05-29	To be published
	8PKM (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	t7m		2.9	2024-05-29	To be published
	8PJK	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	t7m	Gi1/β1/γ1	2.4	2024-05-29	To be published
	8PJK (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	t7m		2.4	2024-05-29	To be published
	8FYX	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gi1/β1/γ1	2.72	2024-05-15	10.1038/s41586-024-07403-2
	8FYX (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.72	2024-05-15	10.1038/s41586-024-07403-2
	8FYT	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-	Gi1/β1/γ1	2.64	2024-05-15	10.1038/s41586-024-07403-2
	8FYT (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-		2.64	2024-05-15	10.1038/s41586-024-07403-2
	8FYL	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-	Gi1/β1/γ1	2.94	2024-05-15	10.1038/s41586-024-07403-2
	8FYL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-		2.94	2024-05-15	10.1038/s41586-024-07403-2
	8FYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-	Gi1/β1/γ1	2.85	2024-05-15	10.1038/s41586-024-07403-2
	8FYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-		2.85	2024-05-15	10.1038/s41586-024-07403-2
	8FY8	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-	Gi1/β1/γ1	2.79	2024-05-15	10.1038/s41586-024-07403-2
	8FY8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-		2.79	2024-05-15	10.1038/s41586-024-07403-2
	8JT6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-	Gi1/β1/γ2	3	2024-02-28	To be published
	8JT6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-		3	2024-02-28	To be published
	8W8B	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-	Gi1/β1/γ2	3	2023-11-22	10.1038/s41586-023-06775-1
	8W8B (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-		3	2023-11-22	10.1038/s41586-023-06775-1
	8JSP	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-	Gi1/β1/γ2	3.65	2023-11-15	10.1038/s41586-023-06804-z
	8JSP (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-		3.65	2023-11-15	10.1038/s41586-023-06804-z
	7E2Z	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-	Gi1/β1/γ2	3.1	2021-04-14	10.1038/s41586-021-03376-8
	7E2Z (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-		3.1	2021-04-14	10.1038/s41586-021-03376-8
	7E2Y	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-	Gi1/β1/γ2	3	2021-04-14	10.1038/s41586-021-03376-8
	7E2Y (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-		3	2021-04-14	10.1038/s41586-021-03376-8
	7E2X	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-	Gi1/β1/γ2	3	2021-04-14	10.1038/s41586-021-03376-8
	7E2X (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-		3	2021-04-14	10.1038/s41586-021-03376-8

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8FYX_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.