psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T39	R:R:V98	6.35	No	Yes	0	5	6
2	R:R:S40	R:R:V98	4.85	No	Yes	0	5	6
3	R:R:A94	R:R:L43	4.73	No	No	0	7	7
4	R:R:L43	R:R:W387	10.25	No	Yes	0	7	8
5	R:R:G44	R:R:I47	3.53	No	No	0	4	7
6	R:R:I47	R:R:L90	7.14	No	No	0	7	8
7	R:R:F48	R:R:L52	4.87	No	No	0	4	4
8	R:R:A50	R:R:S86	3.42	No	No	0	8	8
9	R:R:V51	R:R:V87	4.81	No	No	0	7	6
10	R:R:G53	R:R:L52	3.42	No	No	0	9	4
11	R:R:G53	R:R:Y402	4.35	No	Yes	0	9	6
12	R:R:D82	R:R:N54	6.73	Yes	Yes	0	9	9
13	R:R:L83	R:R:N54	8.24	No	Yes	0	8	9
14	R:R:N54	R:R:S86	4.47	Yes	No	0	9	8
15	R:R:N54	R:R:P397	6.52	Yes	No	0	9	9
16	R:R:C56	R:R:Y402	4.03	No	Yes	0	8	6
17	R:R:A401	R:R:V57	5.09	No	No	0	8	9
18	R:R:V57	R:R:Y402	5.05	No	Yes	0	9	6
19	R:R:A60	R:R:F411	4.16	No	No	0	8	8
20	R:R:F407	R:R:I61	6.28	Yes	No	0	8	8
21	R:R:E64	R:R:S66	5.75	Yes	No	0	7	6
22	R:R:E64	R:R:L67	10.6	Yes	No	0	7	8
23	R:R:A410	R:R:E64	6.03	No	Yes	0	8	7
24	R:R:E64	R:R:K413	9.45	Yes	No	0	7	6
25	R:R:F407	R:R:L67	4.87	Yes	No	0	8	8
26	R:R:Q68	R:R:Y73	7.89	No	No	0	8	6
27	R:R:N69	R:R:N72	14.98	No	No	0	8	9
28	R:R:D133	R:R:V70	4.38	No	No	3	9	7
29	R:R:R148	R:R:V70	11.77	Yes	No	3	8	7
30	R:R:F407	R:R:N72	7.25	Yes	No	0	8	9
31	R:R:I130	R:R:L74	4.28	No	Yes	0	9	8
32	R:R:D133	R:R:L74	4.07	No	Yes	0	9	8
33	R:R:L156	R:R:L74	4.15	No	Yes	0	6	8
34	R:R:I75	R:R:Y400	3.63	No	Yes	0	8	9
35	R:R:F407	R:R:I75	5.02	Yes	No	0	8	8
36	R:R:H126	R:R:S77	6.97	Yes	No	2	8	9
37	R:R:I157	R:R:S77	9.29	No	No	2	8	9
38	R:R:D82	R:R:L78	8.14	Yes	Yes	2	9	9
39	R:R:H126	R:R:L78	7.71	Yes	Yes	2	8	9
40	R:R:L78	R:R:N396	9.61	Yes	Yes	2	9	9
41	R:R:L78	R:R:Y400	3.52	Yes	Yes	2	9	9
42	R:R:S122	R:R:T81	4.8	No	No	2	8	9
43	R:R:H126	R:R:T81	10.95	Yes	No	2	8	9
44	R:R:T81	R:R:W161	9.7	No	Yes	2	9	9
45	R:R:D82	R:R:S393	8.83	Yes	No	0	9	9
46	R:R:D82	R:R:N396	12.12	Yes	Yes	2	9	9
47	R:R:M84	R:R:W161	3.49	No	Yes	0	7	9
48	R:R:S393	R:R:V85	8.08	No	No	0	9	8
49	R:R:L88	R:R:V87	4.47	No	No	0	6	6
50	R:R:D116	R:R:V89	10.22	Yes	No	0	8	8
51	R:R:L90	R:R:W387	3.42	No	Yes	1	8	8
52	R:R:L90	R:R:Y390	3.52	No	Yes	1	8	8
53	R:R:M92	R:R:W102	4.65	No	Yes	1	6	9
54	R:R:F112	R:R:M92	17.42	Yes	No	1	6	6
55	R:R:A93	R:R:W387	3.89	No	Yes	1	7	8
56	R:R:A93	R:R:Y390	5.34	No	Yes	1	7	8
57	L:L:?1	R:R:A93	4.99	Yes	No	1	0	7
58	R:R:L95	R:R:L99	4.15	No	No	0	6	5
59	R:R:W102	R:R:Y96	10.61	Yes	No	1	9	6
60	L:L:?1	R:R:Y96	5.2	Yes	No	1	0	6
61	R:R:A383	R:R:Q97	4.55	No	No	0	6	7
62	R:R:Q97	R:R:W387	4.38	No	Yes	0	7	8
63	R:R:D185	R:R:K101	8.3	No	No	0	4	5
64	R:R:L104	R:R:W102	13.67	No	Yes	0	7	9
65	R:R:C109	R:R:W102	3.92	No	Yes	1	9	9
66	R:R:F112	R:R:W102	4.01	Yes	Yes	1	6	9
67	R:R:C187	R:R:W102	5.22	No	Yes	1	9	9
68	L:L:?1	R:R:W102	7.22	Yes	Yes	1	0	9
69	R:R:F112	R:R:T108	3.89	Yes	No	0	6	6
70	R:R:C109	R:R:C187	7.28	No	No	1	9	9
71	R:R:F112	R:R:L111	3.65	Yes	No	0	6	5
72	L:L:?1	R:R:F112	5.4	Yes	Yes	1	0	6
73	L:L:?1	R:R:I113	7.23	Yes	No	0	0	7
74	R:R:C120	R:R:D116	4.67	No	Yes	1	7	8
75	R:R:D116	R:R:Y390	12.64	Yes	Yes	1	8	8
76	L:L:?1	R:R:D116	12.04	Yes	Yes	1	0	8
77	L:L:?1	R:R:V117	7.55	Yes	No	0	0	8
78	R:R:L118	R:R:W161	5.69	No	Yes	0	6	9
79	R:R:C120	R:R:W358	5.22	No	Yes	1	7	8
80	L:L:?1	R:R:C120	4.02	Yes	No	1	0	7
81	R:R:H126	R:R:S122	4.18	Yes	No	2	8	8
82	R:R:S122	R:R:W161	18.53	No	Yes	2	8	9
83	R:R:F354	R:R:I124	10.05	Yes	No	0	9	8
84	R:R:I124	R:R:W358	9.4	No	Yes	0	8	8
85	R:R:T160	R:R:W125	3.64	No	Yes	0	8	7
86	R:R:I163	R:R:W125	19.97	No	Yes	0	5	7
87	R:R:P207	R:R:W125	13.51	No	Yes	0	9	7
88	R:R:H126	R:R:I157	7.95	Yes	No	2	8	8
89	R:R:H126	R:R:T160	8.21	Yes	No	0	8	8
90	R:R:H126	R:R:W161	6.35	Yes	Yes	2	8	9
91	R:R:L127	R:R:N396	4.12	No	Yes	0	8	9
92	R:R:L127	R:R:Y400	7.03	No	Yes	0	8	9
93	R:R:C128	R:R:M211	4.86	No	No	0	7	9
94	R:R:A129	R:R:L156	6.3	No	No	0	8	6
95	R:R:I130	R:R:R134	6.26	No	No	2	9	9
96	R:R:I130	R:R:Y400	4.84	No	Yes	2	9	9
97	R:R:A131	R:R:Y215	6.67	No	Yes	0	9	9
98	R:R:L132	R:R:W136	12.53	No	No	0	6	5
99	R:R:L132	R:R:L214	6.92	No	No	0	6	7
100	R:R:D133	R:R:R148	8.34	No	Yes	3	9	8
101	R:R:R134	R:R:Y215	7.2	No	Yes	0	9	9
102	R:R:R134	R:R:Y400	4.12	No	Yes	2	9	9
103	R:R:T139	R:R:Y135	11.24	No	Yes	0	8	9
104	R:R:L214	R:R:Y135	5.86	No	Yes	0	7	9
105	R:R:R217	R:R:Y135	11.32	No	Yes	0	7	9
106	R:R:I218	R:R:Y135	4.84	No	Yes	0	9	9
107	R:R:R152	R:R:W136	12	No	No	0	7	5
108	R:R:A137	R:R:Y144	4	No	No	0	8	8
109	R:R:I138	R:R:I218	4.42	No	No	0	9	9
110	R:R:D140	R:R:D143	18.63	No	No	0	7	6
111	R:R:R148	R:R:Y144	13.38	Yes	No	0	8	8
112	R:R:N146	R:R:V145	4.43	No	No	0	5	6
113	R:R:R148	R:R:R152	7.46	Yes	No	0	8	7
114	R:R:P150	R:R:T149	5.25	No	No	0	5	8
115	R:R:R151	R:R:T149	6.47	No	No	0	6	8
116	R:R:I163	R:R:L159	4.28	No	No	0	5	3
117	R:R:L162	R:R:L166	6.92	No	No	0	5	5
118	R:R:F165	R:R:I169	8.79	No	No	0	5	6
119	R:R:I169	R:R:P170	5.08	No	No	0	6	8
120	R:R:I169	R:R:M172	5.83	No	No	0	6	6
121	R:R:P170	R:R:P171	5.84	No	No	5	8	7
122	R:R:P170	R:R:Y195	5.56	No	Yes	5	8	8
123	R:R:P171	R:R:Y195	13.91	No	Yes	5	7	8
124	R:R:G174	R:R:L173	3.42	No	No	0	5	6
125	R:R:D183	R:R:P184	6.44	No	No	4	1	1
126	R:R:D183	R:R:D185	5.32	No	No	4	1	4
127	R:R:A186	R:R:D183	4.63	No	No	0	4	1
128	R:R:D185	R:R:P184	4.83	No	No	4	4	1
129	L:L:?1	R:R:C187	6.03	Yes	No	1	0	9
130	L:L:?1	R:R:I189	6.33	Yes	No	0	0	6
131	R:R:S190	R:R:Y195	3.82	No	Yes	0	6	8
132	R:R:D192	R:R:G194	5.03	No	No	0	6	5
133	R:R:F370	R:R:H193	29.41	No	No	0	5	4
134	R:R:Y195	R:R:Y198	3.97	Yes	No	0	8	5
135	R:R:S199	R:R:Y195	10.17	No	Yes	0	8	8
136	R:R:P369	R:R:T196	5.25	Yes	No	0	7	7
137	R:R:F201	R:R:I197	5.02	No	No	0	5	7
138	R:R:T200	R:R:Y205	8.74	No	Yes	0	7	7
139	R:R:F362	R:R:T200	7.78	Yes	No	0	7	7
140	R:R:F201	R:R:Y205	15.47	No	Yes	0	5	7
141	R:R:F204	R:R:Y205	4.13	Yes	Yes	0	8	7
142	R:R:F204	R:R:F354	8.57	Yes	Yes	0	8	9
143	R:R:F204	R:R:L359	4.87	Yes	Yes	0	8	7
144	R:R:F204	R:R:F362	22.51	Yes	Yes	0	8	7
145	R:R:L366	R:R:Y205	5.86	No	Yes	0	7	7
146	R:R:L208	R:R:L212	5.54	No	No	0	7	6
147	R:R:F354	R:R:L208	3.65	Yes	No	0	9	7
148	R:R:M211	R:R:M351	4.33	No	No	0	9	8
149	R:R:F354	R:R:M211	8.71	Yes	No	0	9	9
150	R:R:L212	R:R:M351	4.24	No	No	0	6	8
151	R:R:I218	R:R:Y215	3.63	No	Yes	0	9	9
152	R:R:L347	R:R:Y215	4.69	No	Yes	0	8	9
153	R:R:I350	R:R:Y215	6.04	No	Yes	0	8	9
154	R:R:M351	R:R:Y215	5.99	No	Yes	0	8	9
155	R:R:F219	R:R:L347	3.65	No	No	0	6	8
156	R:R:R223	R:R:R227	9.6	No	No	0	7	6
157	R:R:E340	R:R:R223	9.3	Yes	No	0	8	7
158	R:R:F224	R:R:K228	8.69	No	No	0	6	5
159	R:R:K228	R:R:R225	7.43	No	No	0	5	7
160	R:R:I226	R:R:R339	3.76	No	No	0	6	7
161	R:R:E340	R:R:I226	5.47	Yes	No	0	8	6
162	R:R:A336	R:R:V230	5.09	No	No	0	5	3
163	R:R:E330	R:R:N328	3.94	No	No	0	4	3
164	R:R:E330	R:R:R333	6.98	No	No	0	4	4
165	R:R:M335	R:R:R339	11.17	No	No	0	4	7
166	R:R:L337	R:R:R341	3.64	No	No	0	5	6
167	R:R:E340	R:R:R341	3.49	Yes	No	0	8	6
168	R:R:I349	R:R:I399	4.42	No	Yes	0	7	8
169	R:R:I350	R:R:Y400	4.84	No	Yes	0	8	9
170	R:R:I399	R:R:T353	4.56	Yes	No	0	8	7
171	R:R:I355	R:R:L359	4.28	No	Yes	0	7	7
172	R:R:L356	R:R:L388	4.15	No	No	0	5	8
173	R:R:C357	R:R:N392	9.45	No	No	0	8	9
174	R:R:F361	R:R:W358	8.02	Yes	Yes	1	8	8
175	R:R:F362	R:R:W358	10.02	Yes	Yes	1	7	8
176	R:R:G389	R:R:W358	5.63	No	Yes	0	8	8
177	R:R:N392	R:R:W358	7.91	No	Yes	0	9	8
178	L:L:?1	R:R:W358	4.33	Yes	Yes	1	0	8
179	R:R:F361	R:R:F362	11.79	Yes	Yes	1	8	7
180	R:R:F361	R:R:N386	3.62	Yes	No	1	8	7
181	L:L:?1	R:R:F361	17.75	Yes	Yes	1	0	8
182	L:L:?1	R:R:F362	7.72	Yes	Yes	1	0	7
183	R:R:L368	R:R:V364	5.96	Yes	No	6	4	6
184	R:R:M377	R:R:V364	6.09	Yes	No	6	4	6
185	R:R:L368	R:R:M377	5.65	Yes	Yes	6	4	4
186	R:R:C371	R:R:S374	3.44	No	No	0	5	5
187	R:R:H376	R:R:P378	7.63	No	No	0	2	7
188	R:R:L381	R:R:P378	4.93	No	No	0	6	7
189	R:R:I384	R:R:L380	4.28	No	No	0	4	3
190	L:L:?1	R:R:N386	8.7	Yes	No	1	0	7
191	R:R:W387	R:R:Y390	13.5	Yes	Yes	1	8	8
192	L:L:?1	R:R:Y390	15.6	Yes	Yes	1	0	8
193	R:R:N392	R:R:N396	12.26	No	Yes	0	9	9
194	R:R:I399	R:R:Y400	4.84	Yes	Yes	0	8	9
195	R:R:F403	R:R:I399	3.77	No	Yes	0	8	8
196	R:R:A401	R:R:F407	8.32	No	Yes	0	8	8
197	R:R:F411	R:R:Y402	6.19	No	Yes	0	8	6
198	R:R:D406	R:R:N404	6.73	No	No	0	7	9
199	R:R:F407	R:R:N404	12.08	Yes	No	0	8	9
200	R:R:I47	R:R:P91	3.39	No	No	0	7	9
201	R:R:A79	R:R:V57	3.39	No	No	0	9	9
202	R:R:I206	R:R:P207	3.39	No	No	0	6	9
203	R:R:I385	R:R:P360	3.39	No	No	0	6	9
204	R:R:A203	R:R:T121	3.36	No	No	0	8	8
205	R:R:M377	R:R:P378	3.35	Yes	No	0	4	7
206	R:R:L359	R:R:P360	3.28	Yes	No	0	7	9
207	R:R:C119	R:R:M84	3.24	No	No	0	7	7
208	R:R:S86	R:R:V51	3.23	No	No	0	8	7
209	R:R:S168	R:R:V117	3.23	No	No	0	8	8
210	R:R:D140	R:R:P141	3.22	No	No	0	7	8
211	R:R:V58	R:R:V80	3.21	No	No	0	7	7
212	R:R:C375	R:R:L368	3.17	No	Yes	0	4	4
213	R:R:A50	R:R:L394	3.15	No	No	0	8	7
214	R:R:A153	R:R:L74	3.15	No	Yes	0	7	8
215	R:R:H193	R:R:P369	3.05	No	Yes	0	4	7
216	R:R:K332	R:R:V230	3.04	No	No	0	6	3
217	R:R:I350	R:R:T346	3.04	No	No	0	8	8
218	R:R:L78	R:R:S123	3	Yes	No	0	9	9
219	R:R:K191	R:R:T188	3	No	No	0	5	5
220	L:L:?1	R:R:A203	2.99	Yes	No	0	0	8
221	R:R:L347	R:R:T343	2.95	No	No	0	8	8
222	R:R:I163	R:R:I167	2.94	No	No	0	5	8
223	R:R:I414	R:R:L63	2.85	No	No	0	7	6
224	R:R:I363	R:R:L359	2.85	No	Yes	0	7	7
225	R:R:I142	R:R:N146	2.83	No	No	0	6	5
226	R:R:E340	R:R:T343	2.82	Yes	No	0	8	8
227	R:R:D140	R:R:I142	2.8	No	No	0	7	6
228	R:R:L394	R:R:L46	2.77	No	No	0	7	7
229	R:R:L104	R:R:L95	2.77	No	No	0	7	6
230	R:R:F219	R:R:V344	2.62	No	No	0	6	8
231	R:R:F403	R:R:V398	2.62	No	No	0	8	6
232	R:R:R339	R:R:T229	2.59	No	No	0	7	4
233	R:R:L210	R:R:W125	2.28	No	Yes	0	7	7
234	R:R:G202	R:R:P207	2.03	No	No	0	5	9
235	R:R:A79	R:R:G76	1.95	No	No	0	9	6
236	L:L:?1	R:R:S199	1.9	Yes	No	0	0	8
237	R:R:G164	R:R:T121	1.82	No	No	0	8	8
238	R:R:C371	R:R:C375	1.82	No	No	0	5	4
239	R:R:G194	R:R:I197	1.76	No	No	0	5	7
240	R:R:G382	R:R:I385	1.76	No	No	0	4	6
241	R:R:G382	R:R:M377	1.75	No	Yes	0	4	4
242	R:R:A114	R:R:S168	1.71	No	No	0	7	8
243	R:R:C371	R:R:V367	1.71	No	No	0	5	6
244	R:R:A79	R:R:V58	1.7	No	No	0	9	7
245	R:R:C49	R:R:T45	1.69	No	No	0	5	4
246	R:R:K191	R:R:P369	1.67	No	Yes	0	5	7
247	R:R:L388	R:R:P360	1.64	No	No	0	8	9
248	R:R:L368	R:R:P369	1.64	Yes	Yes	0	4	7
249	R:R:A221	R:R:I138	1.62	No	No	0	6	9
250	R:R:A336	R:R:I226	1.62	No	No	0	5	6
251	R:R:C49	R:R:L394	1.59	No	No	0	5	7
252	R:R:T108	R:R:V107	1.59	No	No	0	6	4
253	R:R:C119	R:R:L115	1.59	No	No	0	7	5
254	R:R:C357	R:R:L395	1.59	No	No	0	8	6
255	R:R:A71	R:R:N69	1.56	No	No	0	8	8
256	R:R:A331	R:R:N328	1.56	No	No	0	5	3
257	R:R:C109	R:R:Q106	1.53	No	No	0	9	4
258	R:R:F219	R:R:G216	1.51	No	No	0	6	3
259	R:R:L46	R:R:S391	1.5	No	No	0	7	5
260	R:R:K101	R:R:T103	1.5	No	No	0	5	5
261	R:R:G216	R:R:R220	1.5	No	No	0	3	5
262	R:R:K342	R:R:T346	1.5	No	No	0	8	8
263	R:R:L99	R:R:V98	1.49	No	Yes	0	5	6
264	R:R:L104	R:R:T103	1.47	No	No	0	7	5
265	R:R:I414	R:R:I415	1.47	No	No	0	7	7
266	R:R:I349	R:R:K345	1.45	No	No	0	7	7
267	R:R:Q36	R:R:V98	1.43	No	Yes	0	4	6
268	R:R:K101	R:R:N100	1.4	No	No	0	5	5
269	R:R:K147	R:R:N146	1.4	No	No	0	5	5
270	R:R:P150	R:R:Y73	1.39	No	No	0	5	6
271	R:R:L41	R:R:L42	1.38	No	No	0	4	5
272	R:R:D406	R:R:K405	1.38	No	No	0	7	6
273	R:R:K405	R:R:Q408	1.36	No	No	0	6	9
274	R:R:A153	R:R:Y73	1.33	No	No	0	7	6
275	R:R:N409	R:R:Q408	1.32	No	No	0	6	9
276	R:R:V145	R:R:Y144	1.26	No	No	0	6	8
277	R:R:E372	R:R:H193	1.23	No	No	0	3	4
278	R:R:F165	R:R:L166	1.22	No	No	0	5	5
279	R:R:I38	R:R:Y35	1.21	No	No	0	3	4
280	R:R:L337	R:R:R333	1.21	No	No	0	5	4
281	R:R:Q68	R:R:R65	1.17	No	No	0	8	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N54	6.49	4	0	9
2	R:R:E64	7.9575	4	0	7
3	R:R:L74	3.9125	4	0	8
4	R:R:L78	6.396	5	2	9
5	R:R:D82	8.955	4	2	9
6	R:R:V98	3.53	4	0	6
7	R:R:W102	7.04286	7	1	9
8	R:R:F112	6.874	5	1	6
9	R:R:D116	9.8925	4	1	8
10	R:R:W125	9.85	4	0	7
11	R:R:H126	7.47429	7	2	8
12	R:R:Y135	8.315	4	0	9
13	R:R:R148	10.2375	4	3	8
14	R:R:W161	8.752	5	2	9
15	R:R:Y195	7.486	5	5	8
16	R:R:F204	10.02	4	0	8
17	R:R:Y205	8.55	4	0	7
18	R:R:Y215	5.70333	6	0	9
19	R:R:E340	5.27	4	0	8
20	R:R:F354	7.745	4	0	9
21	R:R:W358	7.21857	7	1	8
22	R:R:L359	3.82	4	0	7
23	R:R:F361	10.295	4	1	8
24	R:R:F362	11.964	5	1	7
25	R:R:L368	4.105	4	6	4
26	R:R:P369	2.9025	4	0	7
27	R:R:M377	4.21	4	6	4
28	R:R:W387	7.088	5	1	8
29	R:R:Y390	10.12	5	1	8
30	R:R:N396	9.5275	4	2	9
31	R:R:I399	4.3975	4	0	8
32	R:R:Y400	4.68857	7	2	9
33	R:R:Y402	4.905	4	0	6
34	R:R:F407	7.30333	6	0	8
35	L:L:?1	7.35294	17	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:A93	10.8747	4.99	Yes	No	1	0	7
2	L:L:?1	R:R:W102	32.9861	7.22	Yes	Yes	1	0	9
3	R:R:L104	R:R:W102	26.6574	13.67	No	Yes	0	7	9
4	R:R:L104	R:R:L95	11.5933	2.77	No	No	0	7	6
5	L:L:?1	R:R:Y390	18.4011	15.6	Yes	Yes	1	0	8
6	R:R:V57	R:R:Y402	18.4011	5.05	No	Yes	0	9	6
7	R:R:A401	R:R:V57	31.2145	5.09	No	No	0	8	9
8	R:R:A401	R:R:F407	33.7437	8.32	No	Yes	0	8	8
9	R:R:F407	R:R:I75	70.3454	5.02	Yes	No	0	8	8
10	R:R:I75	R:R:Y400	72.6964	3.63	No	Yes	0	8	9
11	R:R:L78	R:R:Y400	66.2451	3.52	Yes	Yes	2	9	9
12	R:R:L78	R:R:N396	51.8106	9.61	Yes	Yes	2	9	9
13	R:R:N392	R:R:N396	100	12.26	No	Yes	0	9	9
14	R:R:N392	R:R:W358	97.0418	7.91	No	Yes	0	9	8
15	L:L:?1	R:R:W358	77.5543	4.33	Yes	Yes	1	0	8
16	R:R:L127	R:R:Y400	38.663	7.03	No	Yes	0	8	9
17	R:R:L127	R:R:N396	38.6462	4.12	No	Yes	0	8	9
18	R:R:N54	R:R:S86	15.9833	4.47	Yes	No	0	9	8
19	R:R:D82	R:R:N54	20.5627	6.73	Yes	Yes	0	9	9
20	R:R:D82	R:R:N396	10.9582	12.12	Yes	Yes	2	9	9
21	R:R:E64	R:R:L67	10.5794	10.6	Yes	No	0	7	8
22	R:R:F407	R:R:L67	13.1978	4.87	Yes	No	0	8	8
23	R:R:A153	R:R:Y73	10.9916	1.33	No	No	0	7	6
24	R:R:A153	R:R:L74	12.7855	3.15	No	Yes	0	7	8
25	R:R:I130	R:R:L74	40.3287	4.28	No	Yes	0	9	8
26	R:R:I130	R:R:Y400	32.7242	4.84	No	Yes	2	9	9
27	R:R:D133	R:R:L74	23.9889	4.07	No	Yes	0	9	8
28	R:R:D133	R:R:R148	20.5571	8.34	No	Yes	3	9	8
29	R:R:H126	R:R:L78	29.5265	7.71	Yes	Yes	2	8	9
30	R:R:K101	R:R:T103	11.7604	1.5	No	No	0	5	5
31	R:R:L104	R:R:T103	13.6825	1.47	No	No	0	7	5
32	R:R:F354	R:R:I124	16.6741	10.05	Yes	No	0	9	8
33	R:R:I124	R:R:W358	17.4373	9.4	No	Yes	0	8	8
34	R:R:F204	R:R:F354	40.1337	8.57	Yes	Yes	0	8	9
35	R:R:F204	R:R:F362	48.2117	22.51	Yes	Yes	0	8	7
36	L:L:?1	R:R:F362	28.624	7.72	Yes	Yes	1	0	7
37	R:R:H126	R:R:T160	14.4847	8.21	Yes	No	0	8	8
38	R:R:T160	R:R:W125	12.9192	3.64	No	Yes	0	8	7
39	R:R:F354	R:R:M211	53.7827	8.71	Yes	No	0	9	9
40	R:R:R134	R:R:Y400	24.2897	4.12	No	Yes	2	9	9
41	R:R:M351	R:R:Y215	56.273	5.99	No	Yes	0	8	9
42	R:R:M211	R:R:M351	53.9276	4.33	No	No	0	9	8
43	R:R:I218	R:R:Y135	12.4903	4.84	No	Yes	0	9	9
44	R:R:I218	R:R:Y215	18.6072	3.63	No	Yes	0	9	9
45	R:R:R148	R:R:Y144	16.4401	13.38	Yes	No	0	8	8
46	R:R:N146	R:R:V145	11.0585	4.43	No	No	0	5	6
47	R:R:V145	R:R:Y144	12.8635	1.26	No	No	0	6	8
48	R:R:P170	R:R:Y195	11.8273	5.56	No	Yes	5	8	8
49	R:R:S199	R:R:Y195	19.5487	10.17	No	Yes	0	8	8
50	L:L:?1	R:R:S199	21.2535	1.9	Yes	No	0	0	8
51	R:R:F201	R:R:Y205	12.117	15.47	No	Yes	0	5	7
52	R:R:F204	R:R:Y205	12.1783	4.13	Yes	Yes	0	8	7
53	R:R:L368	R:R:P369	13.7103	1.64	Yes	Yes	0	4	7
54	R:R:L368	R:R:M377	23.1978	5.65	Yes	Yes	6	4	4
55	R:R:G382	R:R:M377	32.5404	1.75	No	Yes	0	4	4
56	R:R:G382	R:R:I385	34.3621	1.76	No	No	0	4	6
57	R:R:I385	R:R:P360	36.1727	3.39	No	No	0	6	9
58	R:R:L359	R:R:P360	41.5376	3.28	Yes	No	0	7	9
59	R:R:F204	R:R:L359	46.8022	4.87	Yes	Yes	0	8	7
60	R:R:L347	R:R:Y215	46.6574	4.69	No	Yes	0	8	9
61	R:R:I350	R:R:Y400	27.5209	4.84	No	Yes	0	8	9
62	R:R:E340	R:R:T343	34.4902	2.82	Yes	No	0	8	8
63	R:R:L347	R:R:T343	36.3231	2.95	No	No	0	8	8
64	R:R:E340	R:R:I226	15.3872	5.47	Yes	No	0	8	6
65	R:R:L337	R:R:R341	11.2479	3.64	No	No	0	5	6
66	R:R:E340	R:R:R341	13.4652	3.49	Yes	No	0	8	6
67	R:R:I399	R:R:Y400	15.6769	4.84	Yes	Yes	0	8	9
68	R:R:D406	R:R:N404	10.5794	6.73	No	No	0	7	9
69	R:R:F407	R:R:N404	13.1978	12.08	Yes	No	0	8	9
70	R:R:A79	R:R:V57	10.5794	3.39	No	No	0	9	9
71	R:R:D82	R:R:L78	14.078	8.14	Yes	Yes	2	9	9
72	R:R:R134	R:R:Y215	32.6908	7.2	No	Yes	0	9	9
73	R:R:I350	R:R:Y215	24.4958	6.04	No	Yes	0	8	9
74	R:R:F362	R:R:W358	26.6964	10.02	Yes	Yes	1	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D116	R:R:V89	10.22	1	Yes	No	8	8	1	2
R:R:L90	R:R:W387	3.42	1	No	Yes	8	8	2	2
R:R:L90	R:R:Y390	3.52	1	No	Yes	8	8	2	1
R:R:M92	R:R:W102	4.65	1	No	Yes	6	9	2	1
R:R:F112	R:R:M92	17.42	1	Yes	No	6	6	1	2
R:R:A93	R:R:W387	3.89	1	No	Yes	7	8	1	2
R:R:A93	R:R:Y390	5.34	1	No	Yes	7	8	1	1
L:L:?1	R:R:A93	4.99	1	Yes	No	0	7	0	1
R:R:W102	R:R:Y96	10.61	1	Yes	No	9	6	1	1
L:L:?1	R:R:Y96	5.2	1	Yes	No	0	6	0	1
R:R:L104	R:R:W102	13.67	0	No	Yes	7	9	2	1
R:R:C109	R:R:W102	3.92	1	No	Yes	9	9	2	1
R:R:F112	R:R:W102	4.01	1	Yes	Yes	6	9	1	1
R:R:C187	R:R:W102	5.22	1	No	Yes	9	9	1	1
L:L:?1	R:R:W102	7.22	1	Yes	Yes	0	9	0	1
R:R:F112	R:R:T108	3.89	1	Yes	No	6	6	1	2
R:R:C109	R:R:C187	7.28	1	No	No	9	9	2	1
R:R:F112	R:R:L111	3.65	1	Yes	No	6	5	1	2
L:L:?1	R:R:F112	5.4	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:I113	7.23	1	Yes	No	0	7	0	1
R:R:C120	R:R:D116	4.67	1	No	Yes	7	8	1	1
R:R:D116	R:R:Y390	12.64	1	Yes	Yes	8	8	1	1
L:L:?1	R:R:D116	12.04	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:V117	7.55	1	Yes	No	0	8	0	1
R:R:C120	R:R:W358	5.22	1	No	Yes	7	8	1	1
L:L:?1	R:R:C120	4.02	1	Yes	No	0	7	0	1
R:R:I124	R:R:W358	9.4	0	No	Yes	8	8	2	1
L:L:?1	R:R:C187	6.03	1	Yes	No	0	9	0	1
L:L:?1	R:R:I189	6.33	1	Yes	No	0	6	0	1
R:R:S199	R:R:Y195	10.17	0	No	Yes	8	8	1	2
R:R:F362	R:R:T200	7.78	1	Yes	No	7	7	1	2
R:R:F204	R:R:F362	22.51	0	Yes	Yes	8	7	2	1
R:R:F361	R:R:W358	8.02	1	Yes	Yes	8	8	1	1
R:R:F362	R:R:W358	10.02	1	Yes	Yes	7	8	1	1
R:R:G389	R:R:W358	5.63	0	No	Yes	8	8	2	1
R:R:N392	R:R:W358	7.91	0	No	Yes	9	8	2	1
L:L:?1	R:R:W358	4.33	1	Yes	Yes	0	8	0	1
R:R:F361	R:R:F362	11.79	1	Yes	Yes	8	7	1	1
R:R:F361	R:R:N386	3.62	1	Yes	No	8	7	1	1
L:L:?1	R:R:F361	17.75	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F362	7.72	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N386	8.7	1	Yes	No	0	7	0	1
R:R:W387	R:R:Y390	13.5	1	Yes	Yes	8	8	2	1
L:L:?1	R:R:Y390	15.6	1	Yes	Yes	0	8	0	1
R:R:A203	R:R:T121	3.36	0	No	No	8	8	1	2
R:R:S168	R:R:V117	3.23	0	No	No	8	8	2	1
L:L:?1	R:R:A203	2.99	1	Yes	No	0	8	0	1
L:L:?1	R:R:S199	1.9	1	Yes	No	0	8	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8PKM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.42
Number of Linked Nodes	256
Number of Links	281
Number of Hubs	35
Number of Links mediated by Hubs	149
Number of Communities	6
Number of Nodes involved in Communities	41
Number of Links involved in Communities	60

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	46590
Length Of Smallest Path	3
Average Path Length	11.874
Length of Longest Path	25
Minimum Path Strength	1.34
Average Path Strength	6.25732
Maximum Path Strength	17.15
Minimum Path Correlation	0.7
Average Path Correlation	0.928231
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	52.3067
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.3999
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • cation binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • signaling receptor binding • receptor-receptor interaction • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • behavior • exploration behavior • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • regulation of tube diameter • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • gamma-aminobutyric acid signaling pathway • regulation of behavior • serotonin metabolic process • indole-containing compound metabolic process • serotonin receptor signaling pathway • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • monoatomic ion transport • serotonin secretion • regulation of monoatomic ion transport • regulation of serotonin secretion • serotonin transport • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • somatodendritic compartment • dendrite • dendritic tree
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ZKV
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ZKV
Name	Befiradol
Synonyms	(3-chloro-4-fluorophenyl)(4-fluoro-4-((((5-methylpyridin-2-yl)methyl)amino)methyl)piperidin-1-yl)methanone Befiradol (2E)-2-butenedioate 4-piperidinemethanamine
Identifier
Formula	C20 H22 Cl F2 N3 O
Molecular Weight	393.858
SMILES
PubChem	9865384
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	0
Total Bonds	51
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08908
Sequence	>8PKM_nogp_Chain_R S Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E R S L Q N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N K W T L G Q V T C D L F I A L D V L C C T S S I W H L C A I A L D R Y W A I T D P I D Y V N K R T P R R A A A L I S L T W L I G F L I S I P P M L G D P D A C T I S K D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K T V N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C E S S C H M P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F Q N A F K K I I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7E2X	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2X (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-	Gi1/β1/γ2	3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-		3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	8W8B	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-	Gi1/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8B (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8JSP	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-	Gi1/β1/γ2	3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSP (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-		3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8FY8	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-	Gi1/β1/γ1	2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FY8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-		2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-	Gi1/β1/γ1	2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-		2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-	Gi1/β1/γ1	2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-		2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-	Gi1/β1/γ1	2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-		2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gi1/β1/γ1	2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8JT6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-	Gi1/β1/γ2	3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8JT6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-		3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8PJK	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-	Gi1/β1/γ1	2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PJK (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-		2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gi1/β1/γ1	2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	9GL2	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gs/β1/γ2	3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9GL2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9DYF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-	Gi1/β1/γ2	2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-		2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-	Go/β1/γ2	2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-		2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Go/β1/γ2	2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851

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