psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q36	R:R:V98	2.87	No	No	0	4	6
2	R:R:L41	R:R:V37	2.98	No	No	0	4	5
3	R:R:A94	R:R:L43	4.73	No	No	0	7	7
4	R:R:L43	R:R:W387	11.39	No	No	0	7	8
5	R:R:I47	R:R:L46	4.28	No	No	0	7	7
6	R:R:L46	R:R:S391	6.01	No	No	0	7	5
7	R:R:L394	R:R:L46	2.77	Yes	No	0	7	7
8	R:R:I47	R:R:L90	7.14	No	Yes	0	7	8
9	R:R:F48	R:R:L52	10.96	No	No	0	4	4
10	R:R:A50	R:R:S86	3.42	No	Yes	0	8	8
11	R:R:A50	R:R:L394	3.15	No	Yes	0	8	7
12	R:R:L83	R:R:V51	4.47	No	No	0	8	7
13	R:R:S86	R:R:V51	3.23	Yes	No	0	8	7
14	R:R:D82	R:R:N54	6.73	Yes	No	0	9	9
15	R:R:L83	R:R:N54	5.49	No	No	0	8	9
16	R:R:N54	R:R:P397	4.89	No	No	0	9	9
17	R:R:C56	R:R:F411	2.79	No	Yes	0	8	8
18	R:R:I61	R:R:V57	3.07	No	Yes	2	8	9
19	R:R:A79	R:R:V57	3.39	No	Yes	0	9	9
20	R:R:A401	R:R:V57	3.39	No	Yes	2	8	9
21	R:R:V57	R:R:Y402	3.79	Yes	Yes	0	9	6
22	R:R:F407	R:R:V57	6.55	Yes	Yes	2	8	9
23	R:R:V58	R:R:V80	3.21	No	No	0	7	7
24	R:R:A60	R:R:F407	2.77	No	Yes	2	8	8
25	R:R:A60	R:R:F411	4.16	No	Yes	2	8	8
26	R:R:F407	R:R:I61	5.02	Yes	No	2	8	8
27	R:R:E64	R:R:L63	5.3	Yes	No	0	7	6
28	R:R:I414	R:R:L63	9.99	No	No	0	7	6
29	R:R:E64	R:R:S66	2.87	Yes	No	0	7	6
30	R:R:E64	R:R:L67	6.63	Yes	Yes	2	7	8
31	R:R:A410	R:R:E64	4.53	No	Yes	2	8	7
32	R:R:F407	R:R:L67	3.65	Yes	Yes	2	8	8
33	R:R:A410	R:R:L67	3.15	No	Yes	2	8	8
34	R:R:Q68	R:R:Y73	9.02	No	No	0	8	6
35	R:R:N69	R:R:N72	8.17	No	No	0	8	9
36	R:R:R148	R:R:V70	14.38	Yes	No	0	8	7
37	R:R:P150	R:R:Y73	5.56	No	No	0	5	6
38	R:R:I130	R:R:L74	2.85	No	Yes	0	9	8
39	R:R:D133	R:R:L74	4.07	No	Yes	0	9	8
40	R:R:A153	R:R:L74	3.15	No	Yes	0	7	8
41	R:R:L156	R:R:L74	4.15	No	Yes	0	6	8
42	R:R:H126	R:R:S77	5.58	Yes	No	0	8	9
43	R:R:I157	R:R:S77	7.74	No	No	0	8	9
44	R:R:D82	R:R:L78	5.43	Yes	Yes	0	9	9
45	R:R:H126	R:R:L78	7.71	Yes	Yes	1	8	9
46	R:R:L127	R:R:L78	2.77	Yes	Yes	1	8	9
47	R:R:L78	R:R:N396	4.12	Yes	No	1	9	9
48	R:R:M84	R:R:V80	3.04	No	No	0	7	7
49	R:R:S122	R:R:T81	6.4	No	No	1	8	9
50	R:R:H126	R:R:T81	6.85	Yes	No	1	8	9
51	R:R:T81	R:R:W161	7.28	No	Yes	1	9	9
52	R:R:D82	R:R:S123	5.89	Yes	No	0	9	9
53	R:R:D82	R:R:S393	4.42	Yes	No	0	9	9
54	R:R:L83	R:R:V87	2.98	No	No	0	8	6
55	R:R:L90	R:R:V85	2.98	Yes	No	0	8	8
56	R:R:L90	R:R:S86	3	Yes	Yes	0	8	8
57	R:R:S393	R:R:S86	4.89	No	Yes	0	9	8
58	R:R:L88	R:R:V87	2.98	No	No	0	6	6
59	R:R:L115	R:R:L88	4.15	No	No	0	5	6
60	R:R:L115	R:R:V89	4.47	No	No	0	5	8
61	R:R:D116	R:R:V89	10.22	Yes	No	0	8	8
62	R:R:L90	R:R:Y390	5.86	Yes	Yes	0	8	8
63	R:R:M92	R:R:W102	4.65	No	Yes	0	6	9
64	R:R:F112	R:R:M92	4.98	No	No	0	6	6
65	R:R:A93	R:R:F112	2.77	No	No	0	7	6
66	R:R:A93	R:R:Y390	4	No	Yes	0	7	8
67	R:R:L95	R:R:L99	6.92	No	No	0	6	5
68	R:R:W102	R:R:Y96	9.65	Yes	No	0	9	6
69	R:R:Q97	R:R:W387	12.05	No	No	0	7	8
70	R:R:L99	R:R:V98	2.98	No	No	0	5	6
71	R:R:D185	R:R:K101	5.53	No	No	0	4	5
72	R:R:L104	R:R:W102	11.39	No	Yes	3	7	9
73	R:R:T108	R:R:W102	7.28	No	Yes	3	6	9
74	R:R:C109	R:R:W102	3.92	Yes	Yes	3	9	9
75	R:R:C187	R:R:W102	6.53	Yes	Yes	3	9	9
76	R:R:L104	R:R:T103	2.95	No	No	0	7	5
77	R:R:L104	R:R:T108	7.37	No	No	3	7	6
78	R:R:C109	R:R:Q106	6.1	Yes	No	0	9	4
79	R:R:D110	R:R:Q106	7.83	No	No	0	7	4
80	R:R:C109	R:R:I113	3.27	Yes	No	3	9	7
81	R:R:C109	R:R:C187	7.28	Yes	Yes	3	9	9
82	R:R:D110	R:R:M172	9.7	No	No	0	7	6
83	R:R:C187	R:R:F112	2.79	Yes	No	0	9	6
84	R:R:C187	R:R:I113	3.27	Yes	No	3	9	7
85	R:R:I113	R:R:I189	5.89	No	No	0	7	6
86	R:R:C119	R:R:L115	3.17	No	No	0	7	5
87	R:R:C120	R:R:D116	4.67	No	Yes	1	7	8
88	R:R:D116	R:R:Y390	10.34	Yes	Yes	1	8	8
89	L:L:?1	R:R:D116	8.08	Yes	Yes	1	0	8
90	R:R:I167	R:R:V117	3.07	Yes	No	0	8	8
91	R:R:L118	R:R:W161	5.69	No	Yes	0	6	9
92	R:R:F165	R:R:L118	13.4	No	No	0	5	6
93	R:R:L118	R:R:S168	3	No	No	0	6	8
94	L:L:?1	R:R:C120	10.8	Yes	No	1	0	7
95	R:R:G164	R:R:T121	3.64	No	Yes	0	8	8
96	R:R:I167	R:R:T121	6.08	Yes	Yes	0	8	8
97	R:R:A203	R:R:T121	3.36	No	Yes	0	8	8
98	R:R:H126	R:R:S122	4.18	Yes	No	1	8	8
99	R:R:S122	R:R:W161	18.53	No	Yes	1	8	9
100	R:R:I124	R:R:W358	14.09	No	Yes	0	8	8
101	R:R:I163	R:R:W125	8.22	No	Yes	0	5	7
102	R:R:P207	R:R:W125	6.76	No	Yes	0	9	7
103	R:R:H126	R:R:T160	9.58	Yes	Yes	0	8	8
104	R:R:L127	R:R:M211	2.83	Yes	No	1	8	9
105	R:R:F354	R:R:L127	3.65	Yes	Yes	1	9	8
106	R:R:L127	R:R:N396	6.87	Yes	No	1	8	9
107	R:R:L127	R:R:Y400	7.03	Yes	Yes	1	8	9
108	R:R:C128	R:R:P207	3.77	No	No	0	7	9
109	R:R:C128	R:R:L210	4.76	No	No	0	7	7
110	R:R:I130	R:R:R134	6.26	No	No	1	9	9
111	R:R:I130	R:R:Y400	6.04	No	Yes	1	9	9
112	R:R:A131	R:R:Y215	6.67	No	Yes	0	9	9
113	R:R:L132	R:R:W136	17.08	No	No	0	6	5
114	R:R:L132	R:R:L214	4.15	No	No	0	6	7
115	R:R:D133	R:R:R148	3.57	No	Yes	0	9	8
116	R:R:R134	R:R:Y400	6.17	No	Yes	1	9	9
117	R:R:R134	W:W:?1	9.76	No	Yes	1	9	0
118	R:R:T139	R:R:Y135	17.48	No	Yes	0	8	9
119	R:R:L214	R:R:Y135	5.86	No	Yes	0	7	9
120	R:R:R217	R:R:Y135	11.32	No	Yes	0	7	9
121	R:R:I218	R:R:Y135	3.63	No	Yes	0	9	9
122	R:R:R152	R:R:W136	7	No	No	0	7	5
123	R:R:I138	R:R:T139	3.04	No	No	0	9	8
124	R:R:I138	R:R:I218	2.94	No	No	0	9	9
125	R:R:D140	R:R:D143	9.31	No	No	0	7	6
126	R:R:I142	R:R:P141	3.39	No	No	0	6	8
127	R:R:I142	R:R:N146	4.25	No	No	0	6	5
128	R:R:D143	R:R:K147	12.44	No	No	0	6	5
129	R:R:D143	R:R:R152	5.96	No	No	0	6	7
130	R:R:R148	R:R:Y144	13.38	Yes	No	0	8	8
131	R:R:P150	R:R:T149	5.25	No	No	0	5	8
132	R:R:I157	R:R:T160	3.04	No	Yes	0	8	8
133	R:R:L162	R:R:L166	2.77	No	No	0	5	5
134	R:R:I167	R:R:Y198	6.04	Yes	No	0	8	5
135	R:R:I167	R:R:S199	3.1	Yes	No	0	8	8
136	R:R:I169	R:R:P170	3.39	No	No	0	6	8
137	R:R:I169	R:R:L173	7.14	No	No	0	6	6
138	R:R:P170	R:R:P171	5.84	No	No	0	8	7
139	R:R:P171	R:R:Y195	13.91	No	Yes	0	7	8
140	R:R:S190	R:R:Y195	3.82	No	Yes	0	6	8
141	R:R:D192	R:R:G194	5.03	No	No	0	6	5
142	R:R:D192	R:R:Y195	3.45	No	Yes	0	6	8
143	R:R:F370	R:R:H193	11.31	Yes	No	0	5	4
144	R:R:E372	R:R:H193	3.69	No	No	0	3	4
145	R:R:P369	R:R:T196	5.25	No	No	4	7	7
146	R:R:F370	R:R:T196	3.89	Yes	No	4	5	7
147	R:R:F201	R:R:I197	7.54	No	No	0	5	7
148	L:L:?1	R:R:S199	7.66	Yes	No	0	0	8
149	R:R:F201	R:R:T200	5.19	No	No	1	5	7
150	R:R:T200	R:R:Y205	4.99	No	Yes	1	7	7
151	R:R:F201	R:R:Y205	8.25	No	Yes	1	5	7
152	R:R:A203	R:R:F362	2.77	No	Yes	0	8	7
153	R:R:F204	R:R:Y205	4.13	Yes	Yes	1	8	7
154	R:R:F204	R:R:L208	4.87	Yes	No	0	8	7
155	R:R:F204	R:R:F354	6.43	Yes	Yes	1	8	9
156	R:R:F204	R:R:W358	4.01	Yes	Yes	1	8	8
157	R:R:F204	R:R:L359	6.09	Yes	Yes	0	8	7
158	R:R:F204	R:R:F362	20.36	Yes	Yes	1	8	7
159	R:R:L366	R:R:Y205	5.86	No	Yes	0	7	7
160	R:R:I206	R:R:P207	3.39	No	No	0	6	9
161	R:R:L208	R:R:L212	2.77	No	No	0	7	6
162	R:R:L209	R:R:V213	2.98	No	No	0	5	5
163	R:R:M211	R:R:Y215	8.38	No	Yes	1	9	9
164	R:R:M211	R:R:M351	4.33	No	No	1	9	8
165	R:R:L212	R:R:M351	4.24	No	No	0	6	8
166	R:R:R217	R:R:V213	6.54	No	No	0	7	5
167	R:R:I350	R:R:Y215	3.63	No	Yes	1	8	9
168	R:R:M351	R:R:Y215	3.59	No	Yes	1	8	9
169	R:R:F219	R:R:R223	9.62	No	No	0	6	7
170	R:R:F219	R:R:L347	4.87	No	Yes	0	6	8
171	R:R:R223	R:R:R227	11.73	No	No	0	7	6
172	R:R:I226	R:R:R339	6.26	No	No	0	6	7
173	R:R:E340	R:R:R227	12.79	No	No	0	8	6
174	R:R:A329	R:R:R333	2.77	No	No	0	5	4
175	R:R:M335	R:R:R339	7.44	No	No	0	4	7
176	R:R:K342	R:R:T346	4.5	No	No	1	8	8
177	R:R:K342	W:W:?1	5.66	No	Yes	1	8	0
178	R:R:L347	R:R:T343	2.95	Yes	Yes	0	8	8
179	R:R:I349	R:R:K345	5.82	No	No	1	7	7
180	R:R:K345	W:W:?1	11.33	No	Yes	1	7	0
181	R:R:I350	R:R:T346	3.04	No	No	1	8	8
182	R:R:T346	W:W:?1	9.87	No	Yes	1	8	0
183	R:R:I349	W:W:?1	4.78	No	Yes	1	7	0
184	R:R:I350	W:W:?1	4.78	No	Yes	1	8	0
185	R:R:I399	R:R:T353	7.6	No	No	0	8	7
186	R:R:F354	R:R:I355	3.77	Yes	No	0	9	7
187	R:R:F354	R:R:W358	8.02	Yes	Yes	1	9	8
188	R:R:I355	R:R:L359	2.85	No	Yes	0	7	7
189	R:R:C357	R:R:N392	11.02	No	Yes	0	8	9
190	R:R:F362	R:R:W358	3.01	Yes	Yes	1	7	8
191	R:R:G389	R:R:W358	4.22	No	Yes	0	8	8
192	R:R:N392	R:R:W358	11.3	Yes	Yes	0	9	8
193	R:R:L359	R:R:P360	3.28	Yes	No	0	7	9
194	R:R:I363	R:R:L359	4.28	No	Yes	0	7	7
195	R:R:I385	R:R:P360	3.39	Yes	No	0	6	9
196	R:R:F361	R:R:F362	3.22	No	Yes	1	8	7
197	R:R:F361	R:R:N386	7.25	No	No	0	8	7
198	L:L:?1	R:R:F361	10.36	Yes	No	1	0	8
199	L:L:?1	R:R:F362	8.29	Yes	Yes	1	0	7
200	R:R:L368	R:R:V364	4.47	No	No	0	4	6
201	R:R:I385	R:R:V364	3.07	Yes	No	0	6	6
202	R:R:L368	R:R:M377	4.24	No	No	0	4	4
203	R:R:F370	R:R:P369	5.78	Yes	No	4	5	7
204	R:R:C371	R:R:S374	3.44	No	No	0	5	5
205	R:R:S373	R:R:S374	3.26	No	No	0	3	5
206	R:R:L381	R:R:P378	4.93	No	No	0	6	7
207	R:R:I385	R:R:L381	5.71	Yes	No	0	6	6
208	R:R:N386	R:R:Y390	5.81	No	Yes	0	7	8
209	R:R:W387	R:R:Y390	9.65	No	Yes	0	8	8
210	L:L:?1	R:R:Y390	3.99	Yes	Yes	1	0	8
211	R:R:L395	R:R:N392	6.87	No	Yes	0	6	9
212	R:R:N392	R:R:N396	8.17	Yes	No	0	9	9
213	R:R:L394	R:R:L395	2.77	Yes	No	0	7	6
214	R:R:P397	R:R:Y402	2.78	No	Yes	0	9	6
215	R:R:F403	R:R:V398	5.24	No	No	0	8	6
216	R:R:I399	R:R:Y400	6.04	No	Yes	0	8	9
217	R:R:A401	R:R:F407	4.16	No	Yes	2	8	8
218	R:R:F411	R:R:Y402	9.28	Yes	Yes	0	8	6
219	R:R:Y402	W:W:?1	8.63	Yes	Yes	0	6	0
220	R:R:F403	W:W:?1	26.91	No	Yes	0	8	0
221	R:R:D406	R:R:N404	10.77	No	No	0	7	9
222	R:R:F407	R:R:N404	4.83	Yes	No	0	8	9
223	R:R:K405	W:W:?1	3.78	No	Yes	0	6	0
224	R:R:F407	R:R:F411	8.57	Yes	Yes	2	8	8
225	R:R:L67	R:R:N72	2.75	Yes	No	0	8	9
226	R:R:K405	R:R:Q408	2.71	No	No	0	6	9
227	R:R:S199	R:R:Y195	2.54	No	Yes	0	8	8
228	R:R:F370	R:R:L366	2.44	Yes	No	0	5	7
229	R:R:T121	R:R:W125	2.43	Yes	Yes	0	8	7
230	R:R:T160	R:R:W125	2.43	Yes	Yes	0	8	7
231	R:R:M84	R:R:W161	2.33	No	Yes	0	7	9
232	R:R:E330	R:R:R327	2.33	No	No	0	4	3
233	R:R:C56	R:R:G53	1.96	No	No	0	8	9
234	R:R:A79	R:R:G76	1.95	No	No	0	9	6
235	R:R:G105	R:R:T108	1.82	No	No	0	7	6
236	R:R:G202	R:R:I206	1.76	No	No	0	5	6
237	R:R:G352	R:R:I355	1.76	No	No	0	6	7
238	R:R:G382	R:R:I385	1.76	No	Yes	0	4	6
239	R:R:G44	R:R:L43	1.71	No	No	0	4	7
240	R:R:G53	R:R:L52	1.71	No	No	0	9	4
241	R:R:A114	R:R:S168	1.71	No	No	0	7	8
242	R:R:G348	R:R:L347	1.71	No	Yes	0	7	8
243	R:R:C371	R:R:V367	1.71	No	No	0	5	6
244	R:R:G389	R:R:L388	1.71	No	No	0	8	8
245	R:R:A129	R:R:T160	1.68	No	Yes	0	8	8
246	R:R:A186	R:R:T188	1.68	No	No	0	4	5
247	R:R:A222	R:R:T343	1.68	No	Yes	0	8	8
248	R:R:K191	R:R:P369	1.67	No	No	0	5	7
249	R:R:L90	R:R:P91	1.64	Yes	No	0	8	9
250	R:R:A401	R:R:I75	1.62	No	No	0	8	8
251	R:R:A221	R:R:I138	1.62	No	No	0	6	9
252	R:R:D140	R:R:P141	1.61	No	No	0	7	8
253	R:R:T39	R:R:V98	1.59	No	No	0	5	6
254	R:R:C49	R:R:L394	1.59	No	Yes	0	5	7
255	R:R:T343	R:R:V344	1.59	Yes	No	0	8	8
256	R:R:A131	R:R:L214	1.58	No	No	0	9	7
257	R:R:A336	R:R:L337	1.58	No	No	0	5	5
258	R:R:A329	R:R:N325	1.56	No	No	0	5	5
259	R:R:A71	R:R:D133	1.54	No	No	0	8	9
260	R:R:I363	R:R:V367	1.54	No	No	0	7	6
261	R:R:A383	R:R:Q97	1.52	No	No	0	6	7
262	R:R:I226	R:R:T343	1.52	No	Yes	0	6	8
263	R:R:F219	R:R:G216	1.51	No	No	0	6	3
264	R:R:L99	R:R:T103	1.47	No	No	0	5	5
265	R:R:I414	R:R:I415	1.47	No	No	0	7	7
266	R:R:I163	R:R:L159	1.43	No	No	0	5	3
267	R:R:I384	R:R:L380	1.43	No	No	0	4	3
268	R:R:K332	R:R:N328	1.4	No	No	0	6	3
269	R:R:K413	R:R:N409	1.4	No	No	0	6	6
270	R:R:A137	R:R:R148	1.38	No	Yes	0	8	8
271	R:R:A154	R:R:R151	1.38	No	No	0	4	6
272	R:R:A338	R:R:R341	1.38	No	No	0	5	6
273	R:R:L380	R:R:L381	1.38	No	No	0	3	6
274	R:R:E64	R:R:K413	1.35	Yes	No	0	7	6
275	L:L:?1	R:R:A365	1.34	Yes	No	0	0	8
276	R:R:A153	R:R:Y73	1.33	No	No	0	7	6
277	R:R:A186	R:R:Y96	1.33	No	No	0	4	6
278	R:R:E340	R:R:L337	1.33	No	No	0	8	5
279	R:R:N100	R:R:Q97	1.32	No	No	0	5	7
280	R:R:R151	R:R:T149	1.29	No	No	0	6	8
281	R:R:V145	R:R:Y144	1.26	No	No	0	6	8
282	R:R:F224	R:R:K228	1.24	No	No	0	6	5
283	R:R:L166	R:R:Y198	1.17	No	No	0	5	5
284	R:R:L347	R:R:Y215	1.17	Yes	Yes	0	8	9
285	R:R:R217	R:R:R220	1.07	No	No	0	7	5
286	R:R:F224	R:R:R225	1.07	No	No	0	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V57	4.038	5	2	9
2	R:R:E64	4.136	5	2	7
3	R:R:L67	4.045	4	2	8
4	R:R:L74	3.555	4	0	8
5	R:R:L78	5.0075	4	1	9
6	R:R:D82	5.6175	4	0	9
7	R:R:S86	3.635	4	0	8
8	R:R:L90	4.124	5	0	8
9	R:R:W102	7.23667	6	3	9
10	R:R:C109	5.1425	4	3	9
11	R:R:D116	8.3275	4	1	8
12	R:R:T121	3.8775	4	0	8
13	R:R:W125	4.96	4	0	7
14	R:R:H126	6.78	5	1	8
15	R:R:L127	4.63	5	1	8
16	R:R:Y135	9.5725	4	0	9
17	R:R:R148	8.1775	4	0	8
18	R:R:T160	4.1825	4	0	8
19	R:R:W161	8.4575	4	1	9
20	R:R:I167	4.5725	4	0	8
21	R:R:C187	4.9675	4	3	9
22	R:R:Y195	5.93	4	0	8
23	R:R:F204	7.64833	6	1	8
24	R:R:Y205	5.8075	4	1	7
25	R:R:Y215	4.688	5	1	9
26	R:R:T343	1.935	4	0	8
27	R:R:L347	2.675	4	0	8
28	R:R:F354	5.4675	4	1	9
29	R:R:W358	7.44167	6	1	8
30	R:R:L359	4.125	4	0	7
31	R:R:F362	7.53	5	1	7
32	R:R:F370	5.855	4	4	5
33	R:R:I385	3.4825	4	0	6
34	R:R:Y390	6.60833	6	1	8
35	R:R:N392	9.34	4	0	9
36	R:R:L394	2.57	4	0	7
37	R:R:Y400	6.32	4	1	9
38	R:R:Y402	6.12	4	0	6
39	R:R:F407	5.07857	7	2	8
40	R:R:F411	6.2	4	2	8
41	L:L:?1	7.21714	7	1	0
42	W:W:?1	9.5	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:W387	R:R:Y390	16.1226	9.65	No	Yes	0	8	8
2	R:R:A93	R:R:Y390	79.1485	4	No	Yes	0	7	8
3	R:R:A93	R:R:F112	77.2228	2.77	No	No	0	7	6
4	R:R:F112	R:R:M92	30.9714	4.98	No	No	0	6	6
5	R:R:M92	R:R:W102	28.8551	4.65	No	Yes	0	6	9
6	R:R:L104	R:R:W102	31.4478	11.39	No	Yes	3	7	9
7	R:R:L104	R:R:T103	27.0448	2.95	No	No	0	7	5
8	R:R:L99	R:R:T103	22.5616	1.47	No	No	0	5	5
9	R:R:L99	R:R:V98	13.565	2.98	No	No	0	5	6
10	R:R:C187	R:R:F112	44.2405	2.79	Yes	No	0	9	6
11	R:R:C187	R:R:W102	28.9554	6.53	Yes	Yes	3	9	9
12	R:R:L90	R:R:Y390	42.7611	5.86	Yes	Yes	0	8	8
13	R:R:L90	R:R:S86	43.3529	3	Yes	Yes	0	8	8
14	R:R:F411	R:R:Y402	36.1767	9.28	Yes	Yes	0	8	6
15	R:R:P397	R:R:Y402	48.5231	2.78	No	Yes	0	9	6
16	R:R:N54	R:R:P397	49.3105	4.89	No	No	0	9	9
17	R:R:D82	R:R:N54	32.4858	6.73	Yes	No	0	9	9
18	R:R:D82	R:R:S393	27.6516	4.42	Yes	No	0	9	9
19	R:R:S393	R:R:S86	27.0097	4.89	No	Yes	0	9	8
20	R:R:L83	R:R:N54	25.1843	5.49	No	No	0	8	9
21	R:R:L83	R:R:V51	19.4925	4.47	No	No	0	8	7
22	R:R:S86	R:R:V51	19.5527	3.23	Yes	No	0	8	7
23	R:R:V57	R:R:Y402	36.1767	3.79	Yes	Yes	0	9	6
24	R:R:F407	R:R:V57	25.5704	6.55	Yes	Yes	2	8	9
25	R:R:F407	R:R:F411	25.771	8.57	Yes	Yes	2	8	8
26	R:R:D82	R:R:L78	24.748	5.43	Yes	Yes	0	9	9
27	R:R:H126	R:R:L78	40.8104	7.71	Yes	Yes	1	8	9
28	R:R:H126	R:R:T81	14.1668	6.85	Yes	No	1	8	9
29	R:R:T81	R:R:W161	12.6323	7.28	No	Yes	1	9	9
30	R:R:H126	R:R:S122	14.1066	4.18	Yes	No	1	8	8
31	R:R:S122	R:R:W161	12.5721	18.53	No	Yes	1	8	9
32	R:R:E64	R:R:L67	25.9014	6.63	Yes	Yes	2	7	8
33	R:R:F407	R:R:L67	40.5396	3.65	Yes	Yes	2	8	8
34	R:R:E64	R:R:L63	11.173	5.3	Yes	No	0	7	6
35	L:L:?1	R:R:Y390	69.48	3.99	Yes	Yes	1	0	8
36	L:L:?1	R:R:F362	87.8542	8.29	Yes	Yes	1	0	7
37	R:R:F204	R:R:F362	63.1062	20.36	Yes	Yes	1	8	7
38	R:R:F204	R:R:F354	53.4978	6.43	Yes	Yes	1	8	9
39	R:R:F354	R:R:L127	100	3.65	Yes	Yes	1	9	8
40	R:R:L127	R:R:Y400	61.3209	7.03	Yes	Yes	1	8	9
41	R:R:I130	R:R:Y400	26.9345	6.04	No	Yes	1	9	9
42	R:R:I130	R:R:L74	33.2932	2.85	No	Yes	0	9	8
43	R:R:A153	R:R:L74	14.8789	3.15	No	Yes	0	7	8
44	R:R:A153	R:R:Y73	12.7827	1.33	No	No	0	7	6
45	R:R:F362	R:R:W358	37.4906	3.01	Yes	Yes	1	7	8
46	R:R:F354	R:R:W358	35.585	8.02	Yes	Yes	1	9	8
47	R:R:D133	R:R:L74	14.8789	4.07	No	Yes	0	9	8
48	R:R:D133	R:R:R148	10.6765	3.57	No	Yes	0	9	8
49	R:R:T160	R:R:W125	16.2529	2.43	Yes	Yes	0	8	7
50	R:R:T121	R:R:W125	17.1757	2.43	Yes	Yes	0	8	7
51	R:R:I167	R:R:T121	15.586	6.08	Yes	Yes	0	8	8
52	R:R:I167	R:R:S199	13.7305	3.1	Yes	No	0	8	8
53	L:L:?1	R:R:S199	33.4988	7.66	Yes	No	0	0	8
54	R:R:A203	R:R:T121	15.7063	3.36	No	Yes	0	8	8
55	R:R:A203	R:R:F362	17.4916	2.77	No	Yes	0	8	7
56	R:R:W102	R:R:Y96	13.565	9.65	Yes	No	0	9	6
57	R:R:L118	R:R:W161	12.7125	5.69	No	Yes	0	6	9
58	R:R:L127	R:R:M211	59.9168	2.83	Yes	No	1	8	9
59	R:R:R134	R:R:Y400	30.7206	6.17	No	Yes	1	9	9
60	R:R:A131	R:R:Y215	54.24	6.67	No	Yes	0	9	9
61	R:R:M211	R:R:Y215	58.1816	8.38	No	Yes	1	9	9
62	R:R:M351	R:R:Y215	22.0902	3.59	No	Yes	1	8	9
63	R:R:L212	R:R:M351	22.4964	4.24	No	No	0	6	8
64	R:R:L208	R:R:L212	22.4262	2.77	No	No	0	7	6
65	R:R:F204	R:R:L208	22.9377	4.87	Yes	No	0	8	7
66	R:R:L132	R:R:L214	22.6869	4.15	No	No	0	6	7
67	R:R:A131	R:R:L214	51.873	1.58	No	No	0	9	7
68	R:R:L132	R:R:W136	20.1896	17.08	No	No	0	6	5
69	R:R:Y402	W:W:?1	40.0933	8.63	Yes	Yes	0	6	0
70	R:R:R134	W:W:?1	38.1375	9.76	No	Yes	1	9	0
71	R:R:L214	R:R:Y135	27.797	5.86	No	Yes	0	7	9
72	R:R:R217	R:R:Y135	10.2452	11.32	No	Yes	0	7	9
73	R:R:R152	R:R:W136	17.6771	7	No	No	0	7	5
74	R:R:D140	R:R:D143	10.2452	9.31	No	No	0	7	6
75	R:R:D143	R:R:R152	15.3051	5.96	No	No	0	6	7
76	R:R:I167	R:R:Y198	10.5862	6.04	Yes	No	0	8	5
77	R:R:P171	R:R:Y195	10.5261	13.91	No	Yes	0	7	8
78	R:R:S199	R:R:Y195	20.8966	2.54	No	Yes	0	8	8
79	R:R:L366	R:R:Y205	11.3334	5.86	No	Yes	0	7	7
80	R:R:F204	R:R:Y205	17.5919	4.13	Yes	Yes	1	8	7
81	R:R:F204	R:R:L359	25.8212	6.09	Yes	Yes	0	8	7
82	R:R:I350	R:R:Y215	19.4574	3.63	No	Yes	1	8	9
83	R:R:F219	R:R:L347	17.6872	4.87	No	Yes	0	6	8
84	R:R:L347	R:R:Y215	37.3301	1.17	Yes	Yes	0	8	9
85	R:R:F219	R:R:R223	12.6423	9.62	No	No	0	6	7
86	R:R:R223	R:R:R227	10.1048	11.73	No	No	0	7	6
87	R:R:L347	R:R:T343	15.1748	2.95	Yes	Yes	0	8	8
88	R:R:F354	R:R:I355	15.4205	3.77	Yes	No	0	9	7
89	R:R:I355	R:R:L359	12.9532	2.85	No	Yes	0	7	7
90	R:R:L359	R:R:P360	23.2035	3.28	Yes	No	0	7	9
91	R:R:I363	R:R:L359	11.7797	4.28	No	Yes	0	7	7
92	R:R:I385	R:R:P360	20.9167	3.39	Yes	No	0	6	9
93	R:R:L127	R:R:L78	30.4498	2.77	Yes	Yes	1	8	9
94	R:R:H126	R:R:T160	16.8848	9.58	Yes	Yes	0	8	8
95	R:R:I350	W:W:?1	15.7465	4.78	No	Yes	1	8	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D116	R:R:V89	10.22	1	Yes	No	8	8	1	2
R:R:L90	R:R:Y390	5.86	0	Yes	Yes	8	8	2	1
R:R:A93	R:R:Y390	4	0	No	Yes	7	8	2	1
R:R:C120	R:R:D116	4.67	1	No	Yes	7	8	1	1
R:R:D116	R:R:Y390	10.34	1	Yes	Yes	8	8	1	1
L:L:?1	R:R:D116	8.08	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:C120	10.8	1	Yes	No	0	7	0	1
R:R:I167	R:R:S199	3.1	0	Yes	No	8	8	2	1
L:L:?1	R:R:S199	7.66	1	Yes	No	0	8	0	1
R:R:A203	R:R:F362	2.77	0	No	Yes	8	7	2	1
R:R:F204	R:R:W358	4.01	1	Yes	Yes	8	8	2	2
R:R:F204	R:R:F362	20.36	1	Yes	Yes	8	7	2	1
R:R:F362	R:R:W358	3.01	1	Yes	Yes	7	8	1	2
R:R:F361	R:R:F362	3.22	1	No	Yes	8	7	1	1
R:R:F361	R:R:N386	7.25	1	No	No	8	7	1	2
L:L:?1	R:R:F361	10.36	1	Yes	No	0	8	0	1
L:L:?1	R:R:F362	8.29	1	Yes	Yes	0	7	0	1
R:R:N386	R:R:Y390	5.81	0	No	Yes	7	8	2	1
R:R:W387	R:R:Y390	9.65	0	No	Yes	8	8	2	1
L:L:?1	R:R:Y390	3.99	1	Yes	Yes	0	8	0	1
R:R:S199	R:R:Y195	2.54	0	No	Yes	8	8	1	2
L:L:?1	R:R:A365	1.34	1	Yes	No	0	8	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V57	R:R:Y402	3.79	2	Yes	Yes	9	6	2	1
R:R:I130	R:R:R134	6.26	1	No	No	9	9	2	1
R:R:I130	R:R:Y400	6.04	1	No	Yes	9	9	2	2
R:R:R134	R:R:Y400	6.17	1	No	Yes	9	9	1	2
R:R:R134	W:W:?1	9.76	1	No	Yes	9	0	1	0
R:R:I350	R:R:Y215	3.63	1	No	Yes	8	9	1	2
R:R:K342	R:R:T346	4.5	1	No	No	8	8	1	1
R:R:K342	W:W:?1	5.66	1	No	Yes	8	0	1	0
R:R:I349	R:R:K345	5.82	1	No	No	7	7	1	1
R:R:K345	W:W:?1	11.33	1	No	Yes	7	0	1	0
R:R:I350	R:R:T346	3.04	1	No	No	8	8	1	1
R:R:T346	W:W:?1	9.87	1	No	Yes	8	0	1	0
R:R:I349	W:W:?1	4.78	1	No	Yes	7	0	1	0
R:R:I350	W:W:?1	4.78	1	No	Yes	8	0	1	0
R:R:P397	R:R:Y402	2.78	0	No	Yes	9	6	2	1
R:R:F403	R:R:V398	5.24	0	No	No	8	6	1	2
R:R:F411	R:R:Y402	9.28	2	Yes	Yes	8	6	2	1
R:R:Y402	W:W:?1	8.63	0	Yes	Yes	6	0	1	0
R:R:F403	W:W:?1	26.91	0	No	Yes	8	0	1	0
R:R:K405	W:W:?1	3.78	0	No	Yes	6	0	1	0
R:R:K405	R:R:Q408	2.71	0	No	No	6	9	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7E2Y_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	255
Number of Links	286
Number of Hubs	42
Number of Links mediated by Hubs	159
Number of Communities	4
Number of Nodes involved in Communities	49
Number of Links involved in Communities	68

Path Summary
Number Of Nodes in MetaPath	96
Number Of Links MetaPath	95
Number of Shortest Paths	59789
Length Of Smallest Path	3
Average Path Length	12.4048
Length of Longest Path	27
Minimum Path Strength	1.155
Average Path Strength	5.57572
Maximum Path Strength	19.12
Minimum Path Correlation	0.7
Average Path Correlation	0.936557
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	55.9271
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	52.141
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cation binding • binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • protein binding • signaling receptor binding • receptor-receptor interaction • tetrapyrrole binding • heme binding • electron transfer activity • transition metal ion binding • iron ion binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • behavior • multicellular organismal process • exploration behavior • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • adult behavior • regulation of tube diameter • system process • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • cell-cell signaling • gamma-aminobutyric acid signaling pathway • regulation of behavior • serotonin metabolic process • indole-containing compound metabolic process • cellular response to nitrogen compound • response to dopamine • serotonin receptor signaling pathway • cellular response to dopamine • response to monoamine • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to catecholamine • cellular response to monoamine stimulus • response to chemical • cellular response to catecholamine stimulus • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • monoatomic ion transport • serotonin secretion • regulation of monoatomic ion transport • regulation of serotonin secretion • serotonin transport • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • electron transport chain • generation of precursor metabolites and energy • cell periphery • cellular anatomical structure • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • synapse • cell junction • periplasmic space • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • establishment of protein localization • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • negative regulation of cellular process • negative regulation of protein localization • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases
SCOP2	Family Identifier	• Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	SRO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	SRO
Name	Serotonin
Synonyms	Serotonin
Identifier
Formula	C10 H12 N2 O
Molecular Weight	176.215
SMILES
PubChem	5202
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	0
Total Bonds	26
Total Aromatic Bonds	10


Code	J40
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	J40
Name	[(2R)-1-[oxidanyl-[(2R,3R,5S,6R)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5E,8E)-hexadeca-5,8,11,14-tetraenoate
Synonyms
Identifier
Formula	C39 H68 O16 P2
Molecular Weight	854.895
SMILES
PubChem
Formal Charge	0
Total Atoms	125
Total Chiral Atoms	5
Total Bonds	125
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08908
Sequence	>7E2Y_nogp_Chain_R Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E R S L Q N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N K W T L G Q V T C D L F I A L D V L C C T S S I W H L C A I A L D R Y W A I T D P I D Y V N K R T P R R A A A L I S L T W L I G F L I S I P P M L G D A C T I S K D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C E S S C H M P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F Q N A F K K I I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7E2X	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	PtdIns4P	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2X (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	PtdIns4P		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	PtdIns4P	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	PtdIns4P		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	PtdIns4P	Gi1/β1/γ2	3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	PtdIns4P		3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	8JSP	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-	Gi1/β1/γ2	3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSP (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-		3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8W8B	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-	Gi1/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8B (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8FY8	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P	Gi1/β1/γ1	2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FY8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P		2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	PtdIns4P	Gi1/β1/γ1	2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	PtdIns4P		2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	PtdIns4P	Gi1/β1/γ1	2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	PtdIns4P		2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	PtdIns4P	Gi1/β1/γ1	2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	PtdIns4P		2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gi1/β1/γ1	2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8PJK	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-	Gi1/β1/γ1	2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PJK (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-		2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gi1/β1/γ1	2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8JT6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	PtdIns4P	Gi1/β1/γ2	3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8JT6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	PtdIns4P		3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	9GL2	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gs/β1/γ2	3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9GL2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9DYD	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P	Go/β1/γ2	2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P		2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Go/β1/γ2	2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P	Gi1/β1/γ2	2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P		2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9VJ5	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Gepirone	-	Go/β1/γ2	2.69	2025-11-12	To be published
	9VJ5 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Gepirone	-		2.69	2025-11-12	To be published
	9VJ6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	F-15599	-	Gi3/β1/γ2	2.62	2025-11-12	To be published
	9VJ6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	F-15599	-		2.62	2025-11-12	To be published
	9VJE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Go/β1/γ2	2.47	2025-11-12	To be published
	9VJE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.47	2025-11-12	To be published
	9VJF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gi3/β1/γ2	2.7	2025-11-12	To be published
	9VJF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.7	2025-11-12	To be published
	9VJG	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	8-OH-DPAT	-	chim(NtGi2-Gz)/β1/γ2	2.67	2025-11-12	To be published
	9VJG (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	8-OH-DPAT	-		2.67	2025-11-12	To be published
	9VMY	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	TMU4142	-	Go/β1/γ2	2.86	2025-11-12	To be published
	9VMY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	TMU4142	-		2.86	2025-11-12	To be published
	9VNF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Pindolol	-	Go/β1/γ2	2.74	2025-11-12	To be published
	9VNF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Pindolol	-		2.74	2025-11-12	To be published
	9KVG	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P	Gi1/β1/γ2	2.63	2025-12-03	To be published
	9KVG (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P		2.63	2025-12-03	To be published
	9KVH	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Cinobufotenine	PtdIns4P	Gi1/β1/γ2	2.59	2025-12-03	To be published
	9KVH (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Cinobufotenine	PtdIns4P		2.59	2025-12-03	To be published
	9KVI	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Bufotenin	PtdIns4P	Gi1/β1/γ2	2.54	2025-12-03	To be published
	9KVI (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Bufotenin	PtdIns4P		2.54	2025-12-03	To be published
	9HYI	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	DP81	-	Gi1/β1/γ2	2.3	2026-01-21	To be published
	9HYI (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	DP81	-		2.3	2026-01-21	To be published

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