psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q36	R:R:Y35	4.51	No	No	0	4	4
2	R:R:Q36	R:R:V98	5.73	No	No	0	4	6
3	R:R:N100	R:R:Q36	6.6	No	No	0	5	4
4	R:R:I38	R:R:V37	3.07	No	No	0	3	5
5	R:R:T39	R:R:V98	3.17	No	No	0	5	6
6	R:R:S40	R:R:V98	3.23	No	No	0	5	6
7	R:R:A94	R:R:L43	4.73	No	No	0	7	7
8	R:R:I47	R:R:L90	7.14	No	Yes	0	7	8
9	R:R:I47	R:R:P91	3.39	No	No	0	7	9
10	R:R:C49	R:R:L394	7.94	No	No	0	5	7
11	R:R:A50	R:R:S86	3.42	No	Yes	0	8	8
12	R:R:S86	R:R:V51	3.23	Yes	No	0	8	7
13	R:R:C56	R:R:L52	3.17	No	No	0	8	4
14	R:R:D82	R:R:N54	13.46	No	No	2	9	9
15	R:R:L83	R:R:N54	6.87	Yes	No	0	8	9
16	R:R:N54	R:R:P397	4.89	No	No	2	9	9
17	R:R:A79	R:R:V57	3.39	No	No	0	9	9
18	R:R:A401	R:R:V57	3.39	No	No	0	8	9
19	R:R:V57	R:R:Y402	3.79	No	Yes	0	9	6
20	R:R:V58	R:R:V80	3.21	No	No	0	7	7
21	R:R:A60	R:R:F411	4.16	No	No	0	8	8
22	R:R:F407	R:R:I61	7.54	Yes	No	0	8	8
23	R:R:I414	R:R:L63	4.28	No	No	0	7	6
24	R:R:E64	R:R:L67	3.98	No	Yes	0	7	8
25	R:R:E64	R:R:I414	4.1	No	No	0	7	7
26	R:R:L67	R:R:S66	3	Yes	No	0	8	6
27	R:R:L67	R:R:N72	2.75	Yes	Yes	5	8	9
28	R:R:D406	R:R:L67	5.43	Yes	Yes	5	7	8
29	R:R:F407	R:R:L67	8.53	Yes	Yes	5	8	8
30	R:R:A410	R:R:L67	3.15	No	Yes	0	8	8
31	R:R:Q68	R:R:Y73	6.76	No	No	0	8	6
32	R:R:N69	R:R:N72	8.17	No	Yes	0	8	9
33	R:R:P150	R:R:V70	3.53	No	No	0	5	7
34	R:R:I75	R:R:N72	2.83	No	Yes	0	8	9
35	R:R:D406	R:R:N72	5.39	Yes	Yes	5	7	9
36	R:R:F407	R:R:N72	13.29	Yes	Yes	5	8	9
37	R:R:P150	R:R:Y73	2.78	No	No	0	5	6
38	R:R:D133	R:R:L74	4.07	No	Yes	0	9	8
39	R:R:A153	R:R:L74	3.15	No	Yes	0	7	8
40	R:R:L156	R:R:L74	4.15	No	Yes	0	6	8
41	R:R:I157	R:R:L74	2.85	No	Yes	0	8	8
42	R:R:I75	R:R:Y400	2.42	No	Yes	0	8	9
43	R:R:H126	R:R:S77	2.79	Yes	No	4	8	9
44	R:R:I157	R:R:S77	10.84	No	No	4	8	9
45	R:R:H126	R:R:L78	7.71	Yes	No	0	8	9
46	R:R:L78	R:R:N396	12.36	No	Yes	0	9	9
47	R:R:T81	R:R:W161	15.77	No	Yes	0	9	9
48	R:R:D82	R:R:S393	8.83	No	No	0	9	9
49	R:R:D82	R:R:P397	3.22	No	No	2	9	9
50	R:R:L83	R:R:S86	3	Yes	Yes	0	8	8
51	R:R:L83	R:R:V87	2.98	Yes	No	0	8	6
52	R:R:M84	R:R:W161	3.49	No	Yes	0	7	9
53	R:R:C119	R:R:V85	8.54	No	No	0	7	8
54	R:R:S393	R:R:V85	3.23	No	No	0	9	8
55	R:R:L90	R:R:S86	3	Yes	Yes	0	8	8
56	R:R:L88	R:R:V87	2.98	No	No	0	6	6
57	R:R:L115	R:R:L88	4.15	No	No	0	5	6
58	R:R:D116	R:R:V89	7.3	No	No	1	8	8
59	R:R:V89	R:R:Y390	2.52	No	Yes	1	8	8
60	R:R:L90	R:R:Y390	4.69	Yes	Yes	0	8	8
61	R:R:F112	R:R:M92	8.71	No	No	0	6	6
62	R:R:A93	R:R:F112	2.77	No	No	0	7	6
63	R:R:A93	R:R:Y390	4	No	Yes	0	7	8
64	R:R:L95	R:R:L99	4.15	No	No	0	6	5
65	R:R:W102	R:R:Y96	8.68	Yes	No	3	9	6
66	R:R:D185	R:R:Y96	17.24	No	No	0	4	6
67	R:R:C187	R:R:Y96	2.69	No	No	3	9	6
68	R:R:Q97	R:R:W387	5.48	No	No	0	7	8
69	R:R:L99	R:R:T103	5.9	No	No	0	5	5
70	R:R:K101	R:R:N100	2.8	No	No	0	5	5
71	R:R:K101	R:R:P184	3.35	No	No	0	5	1
72	R:R:D185	R:R:K101	2.77	No	No	0	4	5
73	R:R:L104	R:R:W102	6.83	No	Yes	3	7	9
74	R:R:T108	R:R:W102	4.85	No	Yes	3	6	9
75	R:R:C109	R:R:W102	6.53	No	Yes	3	9	9
76	R:R:C187	R:R:W102	16.98	No	Yes	3	9	9
77	R:R:L104	R:R:T108	10.32	No	No	3	7	6
78	R:R:Q106	R:R:V107	2.87	No	No	0	4	4
79	R:R:D110	R:R:Q106	5.22	No	No	0	7	4
80	R:R:C109	R:R:C187	7.28	No	No	3	9	9
81	R:R:D110	R:R:M172	8.32	No	No	0	7	6
82	R:R:I113	R:R:I189	8.83	No	No	0	7	6
83	R:R:D116	R:R:Y390	11.49	No	Yes	1	8	8
84	L:L:?1	R:R:D116	5.37	Yes	No	1	0	8
85	R:R:S168	R:R:V117	8.08	No	No	0	8	8
86	L:L:?1	R:R:V117	2.95	Yes	No	0	0	8
87	R:R:L118	R:R:W161	3.42	Yes	Yes	0	6	9
88	R:R:G164	R:R:L118	3.42	No	Yes	0	8	6
89	R:R:F165	R:R:L118	4.87	No	Yes	0	5	6
90	R:R:L118	R:R:S168	7.51	Yes	No	0	6	8
91	R:R:C120	R:R:W358	2.61	No	Yes	1	7	8
92	R:R:C120	R:R:Y390	2.69	No	Yes	1	7	8
93	L:L:?1	R:R:C120	7.85	Yes	No	1	0	7
94	R:R:I167	R:R:T121	4.56	No	No	0	8	8
95	R:R:A203	R:R:T121	3.36	No	No	1	8	8
96	L:L:?1	R:R:T121	8.75	Yes	No	1	0	8
97	R:R:H126	R:R:S122	4.18	Yes	No	4	8	8
98	R:R:S122	R:R:T160	3.2	No	No	4	8	8
99	R:R:S122	R:R:W161	8.65	No	Yes	0	8	9
100	R:R:I124	R:R:P207	3.39	No	No	0	8	9
101	R:R:F354	R:R:I124	2.51	Yes	No	0	9	8
102	R:R:I124	R:R:W358	8.22	No	Yes	0	8	8
103	R:R:C128	R:R:W125	5.22	No	Yes	0	7	7
104	R:R:T160	R:R:W125	2.43	No	Yes	0	8	7
105	R:R:I163	R:R:W125	12.92	No	Yes	0	5	7
106	R:R:P207	R:R:W125	13.51	No	Yes	0	9	7
107	R:R:H126	R:R:I157	5.3	Yes	No	4	8	8
108	R:R:H126	R:R:T160	17.8	Yes	No	4	8	8
109	R:R:F354	R:R:L127	4.87	Yes	No	0	9	8
110	R:R:L127	R:R:N396	2.75	No	Yes	2	8	9
111	R:R:L127	R:R:Y400	7.03	No	Yes	2	8	9
112	R:R:I130	R:R:R134	6.26	No	No	2	9	9
113	R:R:I130	R:R:Y400	7.25	No	Yes	2	9	9
114	R:R:A131	R:R:Y215	5.34	No	Yes	0	9	9
115	R:R:L132	R:R:W136	6.83	No	No	0	6	5
116	R:R:L132	R:R:L214	2.77	No	No	0	6	7
117	R:R:R134	R:R:Y215	5.14	No	Yes	0	9	9
118	R:R:R134	R:R:Y400	3.09	No	Yes	2	9	9
119	R:R:W136	R:R:Y135	4.82	No	Yes	0	5	9
120	R:R:T139	R:R:Y135	8.74	No	Yes	0	8	9
121	R:R:R217	R:R:Y135	7.2	No	Yes	0	7	9
122	R:R:I218	R:R:Y135	4.84	No	Yes	0	9	9
123	R:R:R152	R:R:W136	5	No	No	0	7	5
124	R:R:D140	R:R:T139	7.23	No	No	0	7	8
125	R:R:D140	R:R:D143	3.99	No	No	0	7	6
126	R:R:I142	R:R:N146	2.83	No	No	0	6	5
127	R:R:D143	R:R:K147	5.53	No	No	0	6	5
128	R:R:D143	R:R:R152	5.96	No	No	0	6	7
129	R:R:R148	R:R:Y144	8.23	No	No	0	8	8
130	R:R:K147	R:R:N146	4.2	No	No	0	5	5
131	R:R:R148	R:R:R152	5.33	No	No	0	8	7
132	R:R:P150	R:R:T149	3.5	No	No	0	5	8
133	R:R:R151	R:R:T149	2.59	No	No	0	6	8
134	R:R:I167	R:R:Y198	2.42	No	No	0	8	5
135	R:R:I169	R:R:P170	5.08	No	No	0	6	8
136	R:R:P170	R:R:P171	5.84	No	No	0	8	7
137	R:R:P171	R:R:Y195	6.95	No	No	0	7	8
138	R:R:E179	R:R:T177	2.82	No	No	0	3	5
139	R:R:D180	R:R:S182	5.89	No	No	0	4	3
140	R:R:D180	R:R:D183	2.66	No	No	0	4	1
141	R:R:R181	R:R:T188	9.06	No	No	0	4	5
142	R:R:A186	R:R:D183	4.63	No	No	0	4	1
143	L:L:?1	R:R:I189	2.82	Yes	No	0	0	6
144	R:R:D192	R:R:G194	3.35	Yes	No	0	6	5
145	R:R:D192	R:R:Y195	3.45	Yes	No	0	6	8
146	R:R:F370	R:R:H193	9.05	No	No	0	5	4
147	R:R:S199	R:R:Y195	6.36	No	No	0	8	8
148	R:R:P369	R:R:T196	6.99	No	No	0	7	7
149	R:R:F370	R:R:T196	2.59	No	No	0	5	7
150	R:R:F201	R:R:I197	7.54	No	No	0	5	7
151	R:R:F370	R:R:I197	2.51	No	No	0	5	7
152	L:L:?1	R:R:S199	7.43	Yes	No	0	0	8
153	R:R:F362	R:R:T200	5.19	Yes	No	0	7	7
154	R:R:L366	R:R:T200	4.42	No	No	0	7	7
155	R:R:F201	R:R:Y205	7.22	No	Yes	0	5	7
156	L:L:?1	R:R:A203	3.12	Yes	No	1	0	8
157	R:R:F204	R:R:Y205	6.19	Yes	Yes	1	8	7
158	R:R:F204	R:R:F354	5.36	Yes	Yes	0	8	9
159	R:R:F204	R:R:W358	6.01	Yes	Yes	1	8	8
160	R:R:F204	R:R:L359	7.31	Yes	Yes	1	8	7
161	R:R:F204	R:R:F362	10.72	Yes	Yes	1	8	7
162	R:R:L359	R:R:Y205	3.52	Yes	Yes	1	7	7
163	R:R:L366	R:R:Y205	3.52	No	Yes	0	7	7
164	R:R:I206	R:R:P207	3.39	No	No	0	6	9
165	R:R:F354	R:R:L208	2.44	Yes	No	0	9	7
166	R:R:I355	R:R:L208	2.85	No	No	0	7	7
167	R:R:M211	R:R:M351	5.78	No	Yes	0	9	8
168	R:R:F354	R:R:M211	9.95	Yes	No	0	9	9
169	R:R:L212	R:R:M351	4.24	No	Yes	0	6	8
170	R:R:R217	R:R:V213	5.23	No	No	0	7	5
171	R:R:I218	R:R:Y215	2.42	No	Yes	0	9	9
172	R:R:L347	R:R:Y215	7.03	No	Yes	0	8	9
173	R:R:I350	R:R:Y215	2.42	No	Yes	0	8	9
174	R:R:F219	R:R:R223	6.41	Yes	Yes	0	6	7
175	R:R:F219	R:R:L347	3.65	Yes	No	0	6	8
176	R:R:I226	R:R:R223	2.51	No	Yes	0	6	7
177	R:R:R223	R:R:R227	4.26	Yes	No	6	7	6
178	R:R:E340	R:R:R223	4.65	Yes	Yes	6	8	7
179	R:R:F224	R:R:R225	4.28	No	No	7	6	7
180	R:R:F224	R:R:K228	3.72	No	No	7	6	5
181	R:R:K228	R:R:R225	2.48	No	No	7	5	7
182	R:R:A336	R:R:I226	3.25	No	No	0	5	6
183	R:R:I226	R:R:R339	3.76	No	No	0	6	7
184	R:R:E340	R:R:R227	3.49	Yes	No	6	8	6
185	R:R:K324	R:R:N325	6.99	No	No	0	1	5
186	R:R:E326	R:R:E330	3.81	No	No	0	3	4
187	R:R:A329	R:R:R333	4.15	No	No	0	5	4
188	R:R:E330	R:R:R333	4.65	No	No	0	4	4
189	R:R:M335	R:R:R339	8.69	No	No	0	4	7
190	R:R:E340	R:R:L337	7.95	Yes	No	0	8	5
191	R:R:A338	R:R:R339	2.77	No	No	0	5	7
192	R:R:L347	R:R:M351	2.83	No	Yes	0	8	8
193	R:R:I355	R:R:L359	2.85	No	Yes	0	7	7
194	R:R:C357	R:R:N392	4.72	No	No	0	8	9
195	R:R:F362	R:R:W358	3.01	Yes	Yes	1	7	8
196	R:R:G389	R:R:W358	8.44	No	Yes	0	8	8
197	R:R:N392	R:R:W358	11.3	No	Yes	0	9	8
198	L:L:?1	R:R:W358	3.38	Yes	Yes	1	0	8
199	R:R:L359	R:R:P360	3.28	Yes	No	0	7	9
200	R:R:F361	R:R:F362	3.22	Yes	Yes	1	8	7
201	R:R:F361	R:R:I385	5.02	Yes	No	0	8	6
202	R:R:F361	R:R:N386	2.42	Yes	No	0	8	7
203	L:L:?1	R:R:F361	13.25	Yes	Yes	1	0	8
204	L:L:?1	R:R:F362	7.23	Yes	Yes	1	0	7
205	R:R:L368	R:R:V364	2.98	No	No	0	4	6
206	R:R:I385	R:R:V364	7.68	No	No	0	6	6
207	R:R:L368	R:R:V367	2.98	No	No	0	4	6
208	R:R:S373	R:R:V367	3.23	No	No	0	3	6
209	R:R:L368	R:R:M377	4.24	No	No	0	4	4
210	R:R:C375	R:R:E372	3.04	No	No	0	4	3
211	R:R:L381	R:R:P378	8.21	No	No	0	6	7
212	R:R:G382	R:R:I385	3.53	No	No	0	4	6
213	R:R:N386	R:R:W387	3.39	No	No	0	7	8
214	R:R:L394	R:R:L395	2.77	No	No	0	7	6
215	R:R:N396	R:R:P397	4.89	Yes	No	2	9	9
216	R:R:N396	R:R:Y400	3.49	Yes	Yes	2	9	9
217	R:R:V398	R:R:Y402	2.52	No	Yes	0	6	6
218	R:R:I399	R:R:Y400	7.25	No	Yes	0	8	9
219	R:R:A401	R:R:F407	2.77	No	Yes	0	8	8
220	R:R:F411	R:R:Y402	7.22	No	Yes	0	8	6
221	R:R:D406	R:R:N404	4.04	Yes	No	0	7	9
222	R:R:K405	R:R:Q408	10.85	No	No	0	6	9
223	R:R:D406	R:R:F407	5.97	Yes	Yes	5	7	8
224	R:R:L166	R:R:Y198	2.34	No	No	0	5	5
225	R:R:M92	R:R:W102	2.33	No	Yes	0	6	9
226	R:R:E326	R:R:R327	2.33	No	No	0	3	3
227	R:R:D192	R:R:W175	2.23	Yes	No	0	6	6
228	R:R:A79	R:R:G76	1.95	No	No	0	9	6
229	R:R:G105	R:R:T108	1.82	No	No	0	7	6
230	R:R:G202	R:R:I206	1.76	No	No	0	5	6
231	R:R:P178	R:R:T177	1.75	No	No	0	5	5
232	R:R:G352	R:R:M351	1.75	No	Yes	0	6	8
233	R:R:C371	R:R:S373	1.72	No	No	0	5	3
234	R:R:G53	R:R:L52	1.71	No	No	0	9	4
235	R:R:G174	R:R:L173	1.71	No	No	0	5	6
236	R:R:G389	R:R:L388	1.71	No	No	0	8	8
237	R:R:A79	R:R:V58	1.7	No	No	0	9	7
238	R:R:A153	R:R:V70	1.7	No	No	0	7	7
239	R:R:C357	R:R:T353	1.69	No	No	0	8	7
240	R:R:M377	R:R:P378	1.68	No	No	0	4	7
241	R:R:K191	R:R:P369	1.67	No	No	0	5	7
242	R:R:L380	R:R:P378	1.64	No	No	0	3	7
243	R:R:A94	R:R:I47	1.62	No	No	0	7	7
244	R:R:A114	R:R:I113	1.62	No	No	0	7	7
245	R:R:A137	R:R:I138	1.62	No	No	0	8	9
246	R:R:A221	R:R:I138	1.62	No	No	0	6	9
247	R:R:A383	R:R:I384	1.62	No	No	0	6	4
248	R:R:D140	R:R:P141	1.61	No	No	0	7	8
249	R:R:D183	R:R:P184	1.61	No	No	0	1	1
250	R:R:A331	R:R:K334	1.61	No	No	0	5	5
251	R:R:S190	R:R:T177	1.6	No	No	0	6	5
252	R:R:T343	R:R:V344	1.59	No	No	0	8	8
253	R:R:A55	R:R:L83	1.58	No	Yes	0	5	8
254	R:R:A129	R:R:L156	1.58	No	No	0	8	6
255	R:R:A71	R:R:D133	1.54	No	No	0	8	9
256	R:R:M377	R:R:S374	1.53	No	No	0	4	5
257	R:R:A383	R:R:Q97	1.52	No	No	0	6	7
258	R:R:I350	R:R:T346	1.52	No	No	0	8	8
259	R:R:I349	R:R:T353	1.52	No	No	0	7	7
260	R:R:F219	R:R:G216	1.51	Yes	No	0	6	3
261	R:R:L41	R:R:S40	1.5	No	No	0	4	5
262	R:R:G174	R:R:R176	1.5	No	No	0	5	6
263	R:R:L395	R:R:S391	1.5	No	No	0	6	5
264	R:R:N396	R:R:S123	1.49	Yes	No	0	9	9
265	R:R:L104	R:R:T103	1.47	No	No	0	7	5
266	R:R:D192	R:R:S190	1.47	Yes	No	0	6	6
267	R:R:C375	R:R:H376	1.47	No	No	0	4	2
268	R:R:G53	R:R:Y402	1.45	No	Yes	0	9	6
269	R:R:I206	R:R:L210	1.43	No	No	0	6	7
270	R:R:G174	R:R:W175	1.41	No	No	0	5	6
271	R:R:A365	R:R:F361	1.39	No	Yes	0	8	8
272	R:R:L41	R:R:L42	1.38	No	No	0	4	5
273	R:R:L46	R:R:L90	1.38	No	Yes	0	7	8
274	R:R:L394	R:R:L46	1.38	No	No	0	7	7
275	R:R:A186	R:R:R181	1.38	No	No	0	4	4
276	R:R:L209	R:R:L212	1.38	No	No	0	5	6
277	R:R:E64	R:R:K413	1.35	No	No	0	7	6
278	R:R:E326	R:R:K324	1.35	No	No	0	3	1
279	R:R:E330	R:R:K334	1.35	No	No	0	4	5
280	R:R:N409	R:R:Q408	1.32	No	No	0	6	9
281	R:R:F48	R:R:V51	1.31	No	No	0	4	7
282	R:R:F219	R:R:V344	1.31	Yes	No	0	6	8
283	R:R:F403	R:R:V398	1.31	No	No	0	8	6
284	R:R:V145	R:R:Y144	1.26	No	No	0	6	8
285	R:R:I363	R:R:Y205	1.21	No	Yes	0	7	7
286	R:R:E340	R:R:R341	1.16	Yes	No	0	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L67	4.47333	6	5	8
2	R:R:N72	6.486	5	5	9
3	R:R:L74	3.555	4	0	8
4	R:R:L83	3.6075	4	0	8
5	R:R:S86	3.1625	4	0	8
6	R:R:L90	4.0525	4	0	8
7	R:R:W102	7.7	6	3	9
8	R:R:L118	4.805	4	0	6
9	R:R:W125	8.52	4	0	7
10	R:R:H126	7.556	5	4	8
11	R:R:Y135	6.4	4	0	9
12	R:R:W161	7.8325	4	0	9
13	R:R:D192	2.625	4	0	6
14	R:R:F204	7.118	5	1	8
15	R:R:Y205	4.332	5	1	7
16	R:R:Y215	4.47	5	0	9
17	R:R:F219	3.22	4	0	6
18	R:R:R223	4.4575	4	6	7
19	R:R:E340	4.3125	4	6	8
20	R:R:M351	3.65	4	0	8
21	R:R:F354	5.026	5	0	9
22	R:R:W358	6.13857	7	1	8
23	R:R:L359	4.24	4	1	7
24	R:R:F361	5.06	5	1	8
25	R:R:F362	5.874	5	1	7
26	R:R:Y390	5.078	5	1	8
27	R:R:N396	4.996	5	2	9
28	R:R:Y400	5.08833	6	2	9
29	R:R:Y402	3.745	4	0	6
30	R:R:D406	5.2075	4	5	7
31	R:R:F407	7.62	5	5	8
32	L:L:?1	6.215	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q36	R:R:V98	13.7957	5.73	No	No	0	4	6
2	R:R:L90	R:R:Y390	27.762	4.69	Yes	Yes	0	8	8
3	R:R:A93	R:R:Y390	77.5314	4	No	Yes	0	7	8
4	R:R:A93	R:R:F112	75.2511	2.77	No	No	0	7	6
5	R:R:F112	R:R:M92	72.9392	8.71	No	No	0	6	6
6	R:R:M92	R:R:W102	70.5009	2.33	No	Yes	0	6	9
7	R:R:W102	R:R:Y96	47.8744	8.68	Yes	No	3	9	6
8	R:R:D185	R:R:Y96	45.5309	17.24	No	No	0	4	6
9	R:R:D185	R:R:K101	42.9474	2.77	No	No	0	4	5
10	R:R:K101	R:R:N100	21.8243	2.8	No	No	0	5	5
11	R:R:N100	R:R:Q36	19.127	6.6	No	No	0	5	4
12	R:R:L46	R:R:L90	10.1636	1.38	No	Yes	0	7	8
13	R:R:L90	R:R:S86	19.5692	3	Yes	Yes	0	8	8
14	R:R:V57	R:R:Y402	17.1246	3.79	No	Yes	0	9	6
15	R:R:A401	R:R:V57	27.4209	3.39	No	No	0	8	9
16	R:R:A401	R:R:F407	29.4422	2.77	No	Yes	0	8	8
17	R:R:F407	R:R:N72	32.5374	13.29	Yes	Yes	5	8	9
18	R:R:I75	R:R:N72	54.5701	2.83	No	Yes	0	8	9
19	R:R:I75	R:R:Y400	56.4146	2.42	No	Yes	0	8	9
20	R:R:L127	R:R:Y400	77.8662	7.03	No	Yes	2	8	9
21	R:R:F354	R:R:L127	92.8305	4.87	Yes	No	0	9	8
22	R:R:F354	R:R:I124	57.1284	2.51	Yes	No	0	9	8
23	R:R:I124	R:R:W358	68.3911	8.22	No	Yes	0	8	8
24	R:R:C120	R:R:W358	62.8766	2.61	No	Yes	1	7	8
25	R:R:C120	R:R:Y390	79.6096	2.69	No	Yes	1	7	8
26	R:R:F204	R:R:F354	100	5.36	Yes	Yes	0	8	9
27	R:R:F204	R:R:W358	58.8529	6.01	Yes	Yes	1	8	8
28	R:R:L83	R:R:N54	16.114	6.87	Yes	No	0	8	9
29	R:R:L83	R:R:S86	17.472	3	Yes	Yes	0	8	8
30	R:R:N54	R:R:P397	13.6125	4.89	No	No	2	9	9
31	R:R:L67	R:R:N72	14.2316	2.75	Yes	Yes	5	8	9
32	R:R:I124	R:R:P207	23.7509	3.39	No	No	0	8	9
33	R:R:P207	R:R:W125	17.4594	13.51	No	Yes	0	9	7
34	R:R:T160	R:R:W125	14.3326	2.43	No	Yes	0	8	7
35	R:R:H126	R:R:T160	12.8608	17.8	Yes	No	4	8	8
36	R:R:H126	R:R:I157	25.7785	5.3	Yes	No	4	8	8
37	R:R:I157	R:R:L74	23.9467	2.85	No	Yes	0	8	8
38	R:R:A153	R:R:L74	14.1874	3.15	No	Yes	0	7	8
39	R:R:A153	R:R:V70	12.1976	1.7	No	No	0	7	7
40	R:R:P150	R:R:V70	10.1952	3.53	No	No	0	5	7
41	R:R:L78	R:R:N396	22.2854	12.36	No	Yes	0	9	9
42	R:R:L127	R:R:N396	14.1684	2.75	No	Yes	2	8	9
43	R:R:N396	R:R:P397	20.8641	4.89	Yes	No	2	9	9
44	R:R:D116	R:R:Y390	18.388	11.49	No	Yes	1	8	8
45	L:L:?1	R:R:D116	23.7193	5.37	Yes	No	1	0	8
46	L:L:?1	R:R:V117	19.7082	2.95	Yes	No	0	0	8
47	R:R:S168	R:R:V117	16.4424	8.08	No	No	0	8	8
48	R:R:L118	R:R:S168	13.802	7.51	Yes	No	0	6	8
49	R:R:L118	R:R:W161	11.2248	3.42	Yes	Yes	0	6	9
50	L:L:?1	R:R:C120	18.4259	7.85	Yes	No	1	0	7
51	R:R:L104	R:R:W102	10.9848	6.83	No	Yes	3	7	9
52	L:L:?1	R:R:F361	22.039	13.25	Yes	Yes	1	0	8
53	R:R:F361	R:R:N386	11.7996	2.42	Yes	No	0	8	7
54	R:R:K101	R:R:P184	19.2281	3.35	No	No	0	5	1
55	L:L:?1	R:R:I189	10.7132	2.82	Yes	No	0	0	6
56	R:R:I167	R:R:T121	11.0227	4.56	No	No	0	8	8
57	L:L:?1	R:R:T121	14.6485	8.75	Yes	No	1	0	8
58	R:R:S122	R:R:W161	10.391	8.65	No	Yes	0	8	9
59	R:R:R134	R:R:Y400	57.7475	3.09	No	Yes	2	9	9
60	R:R:R134	R:R:Y215	56.4525	5.14	No	Yes	0	9	9
61	R:R:L347	R:R:Y215	45.2719	7.03	No	Yes	0	8	9
62	R:R:L347	R:R:M351	58.6507	2.83	No	Yes	0	8	8
63	R:R:M211	R:R:M351	64.8917	5.78	No	Yes	0	9	8
64	R:R:F354	R:R:M211	66.6288	9.95	Yes	No	0	9	9
65	R:R:W136	R:R:Y135	36.9149	4.82	No	Yes	0	5	9
66	R:R:I218	R:R:Y135	70.1661	4.84	No	Yes	0	9	9
67	R:R:I218	R:R:Y215	73.3813	2.42	No	Yes	0	9	9
68	R:R:T139	R:R:Y135	23.6877	8.74	No	Yes	0	8	9
69	R:R:D140	R:R:T139	20.3335	7.23	No	No	0	7	8
70	R:R:D140	R:R:D143	13.6757	3.99	No	No	0	7	6
71	R:R:D143	R:R:R152	13.7705	5.96	No	No	0	6	7
72	R:R:R152	R:R:W136	26.9219	5	No	No	0	7	5
73	R:R:K147	R:R:N146	13.6378	4.2	No	No	0	5	5
74	R:R:D143	R:R:K147	20.4409	5.53	No	No	0	6	5
75	R:R:R148	R:R:R152	10.3405	5.33	No	No	0	8	7
76	R:R:P171	R:R:Y195	11.0227	6.95	No	No	0	7	8
77	R:R:S199	R:R:Y195	50.4895	6.36	No	No	0	8	8
78	L:L:?1	R:R:S199	54.0016	7.43	Yes	No	0	0	8
79	R:R:S190	R:R:T177	11.0227	1.6	No	No	0	6	5
80	R:R:D192	R:R:S190	14.6737	1.47	Yes	No	0	6	6
81	R:R:D192	R:R:Y195	36.3148	3.45	Yes	No	0	6	8
82	R:R:D183	R:R:P184	16.5182	1.61	No	No	0	1	1
83	R:R:F201	R:R:I197	11.8944	7.54	No	No	0	5	7
84	R:R:F201	R:R:Y205	13.8336	7.22	No	Yes	0	5	7
85	R:R:F204	R:R:Y205	18.6406	6.19	Yes	Yes	1	8	7
86	L:L:?1	R:R:F362	25.9049	7.23	Yes	Yes	1	0	7
87	R:R:F219	R:R:L347	30.156	3.65	Yes	No	0	6	8
88	R:R:F219	R:R:R223	21.6664	6.41	Yes	Yes	0	6	7
89	R:R:I226	R:R:R223	10.9027	2.51	No	Yes	0	6	7
90	R:R:N392	R:R:W358	10.151	11.3	No	Yes	0	9	8
91	R:R:F361	R:R:I385	27.9641	5.02	Yes	No	0	8	6
92	R:R:L368	R:R:V364	21.1421	2.98	No	No	0	4	6
93	R:R:I385	R:R:V364	23.4287	7.68	No	No	0	6	6
94	R:R:L368	R:R:M377	11.8691	4.24	No	No	0	4	4
95	R:R:D192	R:R:W175	14.6737	2.23	Yes	No	0	6	6
96	R:R:G174	R:R:W175	11.0227	1.41	No	No	0	5	6
97	R:R:N396	R:R:Y400	24.0288	3.49	Yes	Yes	2	9	9
98	R:R:H126	R:R:L78	20.3777	7.71	Yes	No	0	8	9
99	L:L:?1	R:R:W358	53.1363	3.38	Yes	Yes	1	0	8
100	R:R:F204	R:R:F362	42.341	10.72	Yes	Yes	1	8	7
101	R:R:F361	R:R:F362	21.3252	3.22	Yes	Yes	1	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D116	R:R:V89	7.3	1	No	No	8	8	1	2
R:R:V89	R:R:Y390	2.52	1	No	Yes	8	8	2	2
R:R:I113	R:R:I189	8.83	0	No	No	7	6	2	1
R:R:D116	R:R:Y390	11.49	1	No	Yes	8	8	1	2
L:L:?1	R:R:D116	5.37	1	Yes	No	0	8	0	1
R:R:S168	R:R:V117	8.08	0	No	No	8	8	2	1
L:L:?1	R:R:V117	2.95	1	Yes	No	0	8	0	1
R:R:C120	R:R:W358	2.61	1	No	Yes	7	8	1	1
R:R:C120	R:R:Y390	2.69	1	No	Yes	7	8	1	2
L:L:?1	R:R:C120	7.85	1	Yes	No	0	7	0	1
R:R:I167	R:R:T121	4.56	0	No	No	8	8	2	1
R:R:A203	R:R:T121	3.36	1	No	No	8	8	1	1
L:L:?1	R:R:T121	8.75	1	Yes	No	0	8	0	1
R:R:I124	R:R:W358	8.22	0	No	Yes	8	8	2	1
L:L:?1	R:R:I189	2.82	1	Yes	No	0	6	0	1
R:R:S199	R:R:Y195	6.36	0	No	No	8	8	1	2
L:L:?1	R:R:S199	7.43	1	Yes	No	0	8	0	1
R:R:F362	R:R:T200	5.19	1	Yes	No	7	7	1	2
L:L:?1	R:R:A203	3.12	1	Yes	No	0	8	0	1
R:R:F204	R:R:W358	6.01	1	Yes	Yes	8	8	2	1
R:R:F204	R:R:F362	10.72	1	Yes	Yes	8	7	2	1
R:R:F362	R:R:W358	3.01	1	Yes	Yes	7	8	1	1
R:R:G389	R:R:W358	8.44	0	No	Yes	8	8	2	1
R:R:N392	R:R:W358	11.3	0	No	Yes	9	8	2	1
L:L:?1	R:R:W358	3.38	1	Yes	Yes	0	8	0	1
R:R:F361	R:R:F362	3.22	1	Yes	Yes	8	7	1	1
R:R:F361	R:R:I385	5.02	1	Yes	No	8	6	1	2
R:R:F361	R:R:N386	2.42	1	Yes	No	8	7	1	2
L:L:?1	R:R:F361	13.25	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F362	7.23	1	Yes	Yes	0	7	0	1
R:R:A365	R:R:F361	1.39	0	No	Yes	8	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JSP_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.42
Number of Linked Nodes	265
Number of Links	286
Number of Hubs	32
Number of Links mediated by Hubs	130
Number of Communities	7
Number of Nodes involved in Communities	42
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	102
Number Of Links MetaPath	101
Number of Shortest Paths	49211
Length Of Smallest Path	3
Average Path Length	13.0231
Length of Longest Path	30
Minimum Path Strength	1.38
Average Path Strength	5.19501
Maximum Path Strength	13.215
Minimum Path Correlation	0.7
Average Path Correlation	0.943107
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	59.3562
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.3443
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cation binding • binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • protein binding • signaling receptor binding • receptor-receptor interaction • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • behavior • multicellular organismal process • exploration behavior • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • regulation of tube diameter • system process • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • cell-cell signaling • gamma-aminobutyric acid signaling pathway • regulation of behavior • serotonin metabolic process • indole-containing compound metabolic process • cellular response to nitrogen compound • response to dopamine • serotonin receptor signaling pathway • cellular response to dopamine • response to monoamine • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to catecholamine • cellular response to monoamine stimulus • response to chemical • cellular response to catecholamine stimulus • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • monoatomic ion transport • serotonin secretion • regulation of monoatomic ion transport • regulation of serotonin secretion • serotonin transport • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell periphery • cellular anatomical structure • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • establishment of protein localization • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • amide transport • negative regulation of cellular process • negative regulation of protein localization • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases
SCOP2	Family Identifier	• Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	UJL
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	UJL
Name	SEP-363856
Synonyms	Ulotaront; SEP-363856; SEP-856
Identifier
Formula	C9 H13 N O S
Molecular Weight	183.271
SMILES
PubChem	89532783
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	1
Total Bonds	26
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08908
Sequence	>8JSP_nogp_Chain_R Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E R S L Q N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N K W T L G Q V T C D L F I A L D V L C C T S S I W H L C A I A L D R Y W A I T D P I D Y V N K R T P R R A A A L I S L T W L I G F L I S I P P M L G W R T P E D R S D P D A C T I S K D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C E S S C H M P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F Q N A F K K I I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7E2X	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2X (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-	Gi1/β1/γ2	3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-		3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	8W8B	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-	Gi1/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8B (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8JSP	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-	Gi1/β1/γ2	3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSP (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-		3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8FY8	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-	Gi1/β1/γ1	2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FY8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-		2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-	Gi1/β1/γ1	2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-		2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-	Gi1/β1/γ1	2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-		2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-	Gi1/β1/γ1	2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-		2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gi1/β1/γ1	2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8JT6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-	Gi1/β1/γ2	3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8JT6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-		3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8PJK	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-	Gi1/β1/γ1	2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PJK (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-		2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gi1/β1/γ1	2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	9GL2	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gs/β1/γ2	3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9GL2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9DYF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-	Gi1/β1/γ2	2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-		2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-	Go/β1/γ2	2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-		2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Go/β1/γ2	2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8JSP_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.