psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D116	18.79	Yes	No	1	0	8
2	L:L:?1	R:R:V117	11.79	Yes	No	0	0	8
3	L:L:?1	R:R:C120	12.56	Yes	No	1	0	7
4	L:L:?1	R:R:W358	4.51	Yes	Yes	1	0	8
5	L:L:?1	R:R:F361	20.48	Yes	No	1	0	8
6	L:L:?1	R:R:F362	8.43	Yes	Yes	1	0	7
7	L:L:?1	R:R:Y390	11.6	Yes	Yes	1	0	8
8	R:R:T39	R:R:V98	3.17	No	No	0	5	6
9	R:R:S40	R:R:V98	3.23	No	No	0	5	6
10	R:R:A94	R:R:L43	3.15	No	No	0	7	7
11	R:R:L43	R:R:W387	11.39	No	Yes	0	7	8
12	R:R:L394	R:R:L46	4.15	No	No	0	7	7
13	R:R:I47	R:R:L90	4.28	No	Yes	0	7	8
14	R:R:A50	R:R:S86	3.42	No	No	0	8	8
15	R:R:A50	R:R:L394	3.15	No	No	0	8	7
16	R:R:G53	R:R:Y402	4.35	No	Yes	0	9	6
17	R:R:D82	R:R:N54	6.73	Yes	No	0	9	9
18	R:R:L83	R:R:N54	5.49	Yes	No	0	8	9
19	R:R:N54	R:R:P397	6.52	No	No	0	9	9
20	R:R:A79	R:R:V57	3.39	No	No	0	9	9
21	R:R:A401	R:R:V57	3.39	No	No	0	8	9
22	R:R:V57	R:R:Y402	5.05	No	Yes	0	9	6
23	R:R:V58	R:R:V80	3.21	No	No	0	7	7
24	R:R:A60	R:R:F411	4.16	No	No	0	8	8
25	R:R:F407	R:R:I61	6.28	Yes	No	0	8	8
26	R:R:I414	R:R:L63	7.14	No	No	0	7	6
27	R:R:E64	R:R:S66	11.5	No	No	0	7	6
28	R:R:A410	R:R:E64	4.53	No	No	0	8	7
29	R:R:E64	R:R:K413	5.4	No	No	0	7	6
30	R:R:F407	R:R:L67	8.53	Yes	No	0	8	8
31	R:R:A410	R:R:L67	4.73	No	No	0	8	8
32	R:R:Q68	R:R:Y73	5.64	No	No	0	8	6
33	R:R:N69	R:R:N72	10.9	No	No	0	8	9
34	R:R:R148	R:R:V70	11.77	No	No	0	8	7
35	R:R:P150	R:R:V70	3.53	No	No	0	5	7
36	R:R:F407	R:R:N72	6.04	Yes	No	0	8	9
37	R:R:P150	R:R:Y73	4.17	No	No	0	5	6
38	R:R:D133	R:R:L74	5.43	No	No	0	9	8
39	R:R:A153	R:R:L74	3.15	No	No	0	7	8
40	R:R:L156	R:R:L74	4.15	No	No	0	6	8
41	R:R:H126	R:R:S77	6.97	Yes	No	2	8	9
42	R:R:I157	R:R:S77	10.84	No	No	2	8	9
43	R:R:D82	R:R:L78	5.43	Yes	Yes	2	9	9
44	R:R:H126	R:R:L78	7.71	Yes	Yes	2	8	9
45	R:R:L127	R:R:L78	5.54	No	Yes	2	8	9
46	R:R:L78	R:R:N396	9.61	Yes	Yes	2	9	9
47	R:R:L78	R:R:Y400	3.52	Yes	Yes	2	9	9
48	R:R:H126	R:R:T81	8.21	Yes	No	2	8	9
49	R:R:T81	R:R:W161	8.49	No	Yes	2	9	9
50	R:R:D82	R:R:S123	5.89	Yes	No	2	9	9
51	R:R:D82	R:R:S393	4.42	Yes	No	0	9	9
52	R:R:D82	R:R:N396	9.42	Yes	Yes	2	9	9
53	R:R:M84	R:R:W161	3.49	No	Yes	0	7	9
54	R:R:C119	R:R:V85	3.42	No	No	0	7	8
55	R:R:L90	R:R:S86	4.5	Yes	No	0	8	8
56	R:R:S393	R:R:S86	3.26	No	No	0	9	8
57	R:R:L88	R:R:V87	4.47	No	No	0	6	6
58	R:R:F112	R:R:V89	3.93	No	No	0	6	8
59	R:R:D116	R:R:V89	7.3	No	No	1	8	8
60	R:R:V89	R:R:Y390	3.79	No	Yes	1	8	8
61	R:R:L90	R:R:Y390	7.03	Yes	Yes	0	8	8
62	R:R:F112	R:R:M92	8.71	No	No	0	6	6
63	R:R:A93	R:R:Y390	4	No	Yes	0	7	8
64	R:R:L95	R:R:L99	4.15	No	No	0	6	5
65	R:R:W102	R:R:Y96	4.82	Yes	No	3	9	6
66	R:R:C187	R:R:Y96	4.03	Yes	No	3	9	6
67	R:R:A383	R:R:Q97	4.55	No	No	0	6	7
68	R:R:Q97	R:R:W387	5.48	No	Yes	0	7	8
69	R:R:D185	R:R:K101	11.06	No	No	0	4	5
70	R:R:L104	R:R:W102	6.83	No	Yes	3	7	9
71	R:R:T108	R:R:W102	4.85	No	Yes	3	6	9
72	R:R:C109	R:R:W102	5.22	No	Yes	3	9	9
73	R:R:F112	R:R:W102	6.01	No	Yes	0	6	9
74	R:R:C187	R:R:W102	5.22	Yes	Yes	3	9	9
75	R:R:L104	R:R:T103	4.42	No	No	0	7	5
76	R:R:L104	R:R:T108	8.84	No	No	3	7	6
77	R:R:P184	R:R:Q106	4.74	No	No	0	1	4
78	R:R:C109	R:R:C187	7.28	No	Yes	3	9	9
79	R:R:L111	R:R:L115	5.54	No	No	0	5	5
80	R:R:C187	R:R:I113	3.27	Yes	No	0	9	7
81	R:R:I113	R:R:I189	5.89	No	No	0	7	6
82	R:R:D116	R:R:Y390	12.64	No	Yes	1	8	8
83	R:R:S168	R:R:V117	3.23	No	No	0	8	8
84	R:R:L118	R:R:W161	5.69	No	Yes	0	6	9
85	R:R:F165	R:R:L118	12.18	No	No	0	5	6
86	R:R:C120	R:R:W358	3.92	No	Yes	1	7	8
87	R:R:G164	R:R:T121	3.64	No	No	0	8	8
88	R:R:I167	R:R:T121	4.56	No	No	0	8	8
89	R:R:A203	R:R:T121	3.36	No	No	0	8	8
90	R:R:S122	R:R:W161	13.59	No	Yes	0	8	9
91	R:R:N396	R:R:S123	4.47	Yes	No	2	9	9
92	R:R:I124	R:R:P207	3.39	No	Yes	0	8	9
93	R:R:F354	R:R:I124	5.02	Yes	No	0	9	8
94	R:R:I124	R:R:W358	9.4	No	Yes	0	8	8
95	R:R:C128	R:R:W125	3.92	Yes	No	5	7	7
96	R:R:I163	R:R:W125	11.74	No	No	0	5	7
97	R:R:P207	R:R:W125	13.51	Yes	No	5	9	7
98	R:R:H126	R:R:I157	6.63	Yes	No	2	8	8
99	R:R:H126	R:R:T160	15.06	Yes	No	0	8	8
100	R:R:H126	R:R:W161	4.23	Yes	Yes	2	8	9
101	R:R:L127	R:R:N396	9.61	No	Yes	2	8	9
102	R:R:L127	R:R:Y400	5.86	No	Yes	2	8	9
103	R:R:C128	R:R:P207	3.77	Yes	Yes	5	7	9
104	R:R:C128	R:R:L210	4.76	Yes	No	0	7	7
105	R:R:C128	R:R:M211	3.24	Yes	No	0	7	9
106	R:R:A129	R:R:L156	3.15	No	No	0	8	6
107	R:R:I130	R:R:R134	6.26	No	No	2	9	9
108	R:R:I130	R:R:Y400	4.84	No	Yes	2	9	9
109	R:R:A131	R:R:Y215	5.34	No	Yes	0	9	9
110	R:R:L132	R:R:W136	17.08	No	No	0	6	5
111	R:R:L132	R:R:L214	4.15	No	No	0	6	7
112	R:R:D133	R:R:R148	9.53	No	No	0	9	8
113	R:R:R134	R:R:Y215	6.17	No	Yes	0	9	9
114	R:R:R134	R:R:Y400	6.17	No	Yes	2	9	9
115	R:R:T139	R:R:Y135	13.73	No	Yes	0	8	9
116	R:R:L214	R:R:Y135	7.03	No	Yes	0	7	9
117	R:R:R217	R:R:Y135	10.29	No	Yes	0	7	9
118	R:R:I218	R:R:Y135	3.63	No	Yes	0	9	9
119	R:R:R152	R:R:W136	5	No	No	0	7	5
120	R:R:I138	R:R:I218	4.42	No	No	0	9	9
121	R:R:D140	R:R:P141	3.22	No	No	0	7	8
122	R:R:D140	R:R:D143	7.98	No	No	0	7	6
123	R:R:D143	R:R:K147	8.3	No	No	0	6	5
124	R:R:D143	R:R:R152	9.53	No	No	0	6	7
125	R:R:R148	R:R:Y144	11.32	No	No	0	8	8
126	R:R:P150	R:R:T149	5.25	No	No	0	5	8
127	R:R:I167	R:R:Y198	3.63	No	Yes	0	8	5
128	R:R:I169	R:R:P170	3.39	No	Yes	0	6	8
129	R:R:P170	R:R:P171	5.84	Yes	No	4	8	7
130	R:R:P170	R:R:Y195	4.17	Yes	Yes	4	8	8
131	R:R:P170	R:R:Y198	4.17	Yes	Yes	4	8	5
132	R:R:P171	R:R:Y195	12.52	No	Yes	4	7	8
133	R:R:S190	R:R:W175	13.59	No	No	0	6	6
134	R:R:I189	R:R:Y195	3.63	No	Yes	0	6	8
135	R:R:S190	R:R:Y195	3.82	No	Yes	0	6	8
136	R:R:E372	R:R:K191	5.4	No	No	0	3	5
137	R:R:D192	R:R:G194	5.03	No	No	0	6	5
138	R:R:D192	R:R:Y195	3.45	No	Yes	0	6	8
139	R:R:F370	R:R:H193	15.84	No	No	0	5	4
140	R:R:Y195	R:R:Y198	3.97	Yes	Yes	4	8	5
141	R:R:S199	R:R:Y195	8.9	No	Yes	0	8	8
142	R:R:P369	R:R:T196	6.99	Yes	No	0	7	7
143	R:R:F370	R:R:I197	6.28	No	No	0	5	7
144	R:R:F201	R:R:T200	3.89	No	Yes	1	5	7
145	R:R:T200	R:R:Y205	4.99	Yes	Yes	1	7	7
146	R:R:F362	R:R:T200	3.89	Yes	Yes	1	7	7
147	R:R:F201	R:R:Y205	7.22	No	Yes	1	5	7
148	R:R:F204	R:R:Y205	6.19	Yes	Yes	1	8	7
149	R:R:F204	R:R:L208	7.31	Yes	No	1	8	7
150	R:R:F204	R:R:F354	7.5	Yes	Yes	1	8	9
151	R:R:F204	R:R:W358	4.01	Yes	Yes	1	8	8
152	R:R:F204	R:R:L359	8.53	Yes	Yes	0	8	7
153	R:R:F204	R:R:F362	19.29	Yes	Yes	1	8	7
154	R:R:L366	R:R:Y205	7.03	No	Yes	0	7	7
155	R:R:I206	R:R:P207	3.39	No	Yes	0	6	9
156	R:R:L208	R:R:L212	4.15	No	No	0	7	6
157	R:R:F354	R:R:L208	3.65	Yes	No	1	9	7
158	R:R:L210	R:R:L214	5.54	No	No	0	7	7
159	R:R:M211	R:R:M351	4.33	No	No	0	9	8
160	R:R:F354	R:R:M211	7.46	Yes	No	0	9	9
161	R:R:R217	R:R:V213	3.92	No	No	0	7	5
162	R:R:I218	R:R:Y215	3.63	No	Yes	0	9	9
163	R:R:L347	R:R:Y215	4.69	No	Yes	0	8	9
164	R:R:I350	R:R:Y215	7.25	No	Yes	0	8	9
165	R:R:M351	R:R:Y215	3.59	No	Yes	0	8	9
166	R:R:F219	R:R:R223	5.34	Yes	No	0	6	7
167	R:R:F219	R:R:L347	4.87	Yes	No	0	6	8
168	R:R:A222	R:R:T343	3.36	No	No	0	8	8
169	R:R:E340	R:R:R223	6.98	No	No	0	8	7
170	R:R:F224	R:R:K228	6.2	No	No	0	6	5
171	R:R:K228	R:R:R225	4.95	No	No	0	5	7
172	R:R:I226	R:R:R339	3.76	No	No	0	6	7
173	R:R:E340	R:R:R227	13.96	No	No	0	8	6
174	R:R:N325	R:R:N328	6.81	No	No	0	5	3
175	R:R:A329	R:R:R333	4.15	No	No	0	5	4
176	R:R:E330	R:R:R333	11.63	No	No	0	4	4
177	R:R:M335	R:R:R339	9.93	No	No	0	4	7
178	R:R:I349	R:R:K345	4.36	No	No	0	7	7
179	R:R:I349	R:R:I399	4.42	No	No	0	7	8
180	R:R:L395	R:R:T353	4.42	No	No	0	6	7
181	R:R:I399	R:R:T353	6.08	No	No	0	8	7
182	R:R:I355	R:R:L359	4.28	No	Yes	0	7	7
183	R:R:C357	R:R:N392	9.45	No	No	0	8	9
184	R:R:F362	R:R:W358	7.02	Yes	Yes	1	7	8
185	R:R:G389	R:R:W358	7.04	No	Yes	0	8	8
186	R:R:N392	R:R:W358	13.56	No	Yes	0	9	8
187	R:R:L359	R:R:P360	3.28	Yes	No	0	7	9
188	R:R:I363	R:R:L359	7.14	No	Yes	0	7	7
189	R:R:I385	R:R:P360	3.39	No	No	0	6	9
190	R:R:F361	R:R:F362	6.43	No	Yes	1	8	7
191	R:R:F361	R:R:I385	3.77	No	No	0	8	6
192	R:R:M377	R:R:V364	4.56	Yes	No	0	4	6
193	R:R:L368	R:R:M377	5.65	No	Yes	0	4	4
194	R:R:F370	R:R:P369	4.33	No	Yes	0	5	7
195	R:R:S373	R:R:S374	3.26	No	No	0	3	5
196	R:R:M377	R:R:P378	3.35	Yes	No	6	4	7
197	R:R:L381	R:R:M377	4.24	No	Yes	6	6	4
198	R:R:L381	R:R:P378	3.28	No	No	6	6	7
199	R:R:I384	R:R:L380	4.28	No	No	0	4	3
200	R:R:N386	R:R:W387	3.39	No	Yes	1	7	8
201	R:R:N386	R:R:Y390	8.14	No	Yes	1	7	8
202	R:R:W387	R:R:Y390	7.72	Yes	Yes	1	8	8
203	R:R:N392	R:R:N396	12.26	No	Yes	0	9	9
204	R:R:F403	R:R:V398	5.24	No	No	0	8	6
205	R:R:I399	R:R:Y400	7.25	No	Yes	0	8	9
206	R:R:A401	R:R:F407	9.71	No	Yes	0	8	8
207	R:R:F411	R:R:Y402	8.25	No	Yes	0	8	6
208	R:R:D406	R:R:N404	5.39	No	No	0	7	9
209	R:R:F407	R:R:N404	4.83	Yes	No	0	8	9
210	R:R:K405	R:R:Q408	5.42	No	No	0	6	9
211	R:R:F407	R:R:F411	5.36	Yes	No	0	8	8
212	R:R:K191	R:R:T188	3	No	No	0	5	5
213	R:R:L83	R:R:V51	2.98	Yes	No	0	8	7
214	R:R:L83	R:R:V87	2.98	Yes	No	0	8	6
215	R:R:L90	R:R:V85	2.98	Yes	No	0	8	8
216	R:R:N146	R:R:V145	2.96	No	No	0	5	6
217	R:R:L43	R:R:T39	2.95	No	No	0	7	5
218	R:R:L99	R:R:T103	2.95	No	No	0	5	5
219	R:R:I38	R:R:L42	2.85	No	No	0	3	5
220	R:R:I169	R:R:L173	2.85	No	No	0	6	6
221	R:R:I142	R:R:N146	2.83	No	No	0	6	5
222	R:R:G105	R:R:W102	2.81	No	Yes	0	7	9
223	R:R:P397	R:R:Y402	2.78	No	Yes	0	9	6
224	R:R:L115	R:R:L88	2.77	No	No	0	5	6
225	R:R:L162	R:R:L166	2.77	No	No	0	5	5
226	R:R:C56	R:R:Y402	2.69	No	Yes	0	8	6
227	R:R:A137	R:R:Y144	2.67	No	No	0	8	8
228	R:R:F219	R:R:V344	2.62	Yes	No	0	6	8
229	R:R:R151	R:R:T149	2.59	No	No	0	6	8
230	R:R:F219	R:R:T343	2.59	Yes	No	0	6	8
231	R:R:F407	R:R:I75	2.51	Yes	No	0	8	8
232	R:R:I226	R:R:R227	2.51	No	No	0	6	6
233	R:R:F48	R:R:L52	2.44	No	No	0	4	4
234	R:R:Q68	R:R:R65	2.34	No	No	0	8	7
235	R:R:R220	R:R:R223	2.13	No	No	0	5	7
236	R:R:A79	R:R:G76	1.95	No	No	0	9	6
237	R:R:C371	R:R:C375	1.82	No	No	7	5	4
238	R:R:G44	R:R:I47	1.76	No	No	0	4	7
239	R:R:G202	R:R:I167	1.76	No	No	0	5	8
240	R:R:G202	R:R:I206	1.76	No	No	0	5	6
241	R:R:G352	R:R:M351	1.75	No	No	0	6	8
242	R:R:G382	R:R:M377	1.75	No	Yes	0	4	4
243	R:R:C371	R:R:S374	1.72	No	No	7	5	5
244	R:R:C375	R:R:S374	1.72	No	No	7	4	5
245	R:R:G53	R:R:L52	1.71	No	No	0	9	4
246	R:R:G174	R:R:L173	1.71	No	No	0	5	6
247	R:R:G389	R:R:L388	1.71	No	No	0	8	8
248	R:R:A79	R:R:V58	1.7	No	No	0	9	7
249	R:R:C49	R:R:T45	1.69	No	No	0	5	4
250	R:R:A129	R:R:T160	1.68	No	No	0	8	8
251	R:R:A186	R:R:T188	1.68	No	No	0	4	5
252	R:R:A365	R:R:T200	1.68	No	Yes	0	8	7
253	R:R:K191	R:R:P369	1.67	No	Yes	0	5	7
254	R:R:L90	R:R:P91	1.64	Yes	No	0	8	9
255	R:R:L368	R:R:P369	1.64	No	Yes	0	4	7
256	R:R:A60	R:R:I414	1.62	No	No	0	8	7
257	R:R:A221	R:R:I138	1.62	No	No	0	6	9
258	R:R:A336	R:R:I226	1.62	No	No	0	5	6
259	R:R:A114	R:R:M172	1.61	No	No	0	7	6
260	R:R:C49	R:R:L394	1.59	No	No	0	5	7
261	R:R:G194	R:R:H193	1.59	No	No	0	5	4
262	R:R:C375	R:R:L368	1.59	No	No	0	4	4
263	R:R:A55	R:R:L83	1.58	No	Yes	0	5	8
264	R:R:A71	R:R:N69	1.56	No	No	0	8	8
265	R:R:C109	R:R:D110	1.56	No	No	0	9	7
266	R:R:I363	R:R:V367	1.54	No	No	0	7	6
267	R:R:I350	R:R:T346	1.52	No	No	0	8	8
268	R:R:F219	R:R:G216	1.51	Yes	No	0	6	3
269	R:R:L46	R:R:S391	1.5	No	No	0	7	5
270	R:R:K101	R:R:T103	1.5	No	No	0	5	5
271	R:R:K342	R:R:T346	1.5	No	No	0	8	8
272	R:R:L41	R:R:V37	1.49	No	No	0	4	5
273	R:R:K147	R:R:N146	1.4	No	No	0	5	5
274	R:R:K405	R:R:N404	1.4	No	No	0	6	9
275	R:R:D110	R:R:M172	1.39	No	No	0	7	6
276	R:R:A338	R:R:R341	1.38	No	No	0	5	6
277	R:R:N409	R:R:Q408	1.32	No	No	0	6	9
278	R:R:V398	R:R:Y402	1.26	No	Yes	0	6	6
279	R:R:T39	R:R:Y35	1.25	No	No	0	5	4
280	R:R:L337	R:R:R227	1.21	No	No	0	5	6
281	R:R:L166	R:R:Y198	1.17	No	Yes	0	5	5
282	R:R:Q36	R:R:Y35	1.13	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	12.5943	7	1	0
2	R:R:L78	6.362	5	2	9
3	R:R:D82	6.378	5	2	9
4	R:R:L83	3.2575	4	0	8
5	R:R:L90	4.086	5	0	8
6	R:R:W102	5.10857	7	3	9
7	R:R:H126	8.135	6	2	8
8	R:R:C128	3.9225	4	5	7
9	R:R:Y135	8.67	4	0	9
10	R:R:W161	7.098	5	2	9
11	R:R:P170	4.3925	4	4	8
12	R:R:C187	4.95	4	3	9
13	R:R:Y195	5.78	7	4	8
14	R:R:Y198	3.235	4	4	5
15	R:R:T200	3.6125	4	1	7
16	R:R:F204	8.805	6	1	8
17	R:R:Y205	6.3575	4	1	7
18	R:R:P207	6.015	4	5	9
19	R:R:Y215	5.11167	6	0	9
20	R:R:F219	3.386	5	0	6
21	R:R:F354	5.9075	4	1	9
22	R:R:W358	7.06571	7	1	8
23	R:R:L359	5.8075	4	0	7
24	R:R:F362	9.012	5	1	7
25	R:R:P369	3.6575	4	0	7
26	R:R:M377	3.91	5	6	4
27	R:R:W387	6.995	4	1	8
28	R:R:Y390	7.84571	7	1	8
29	R:R:N396	9.074	5	2	9
30	R:R:Y400	5.528	5	2	9
31	R:R:Y402	4.06333	6	0	6
32	R:R:F407	6.18	7	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y390	71.0553	11.6	Yes	Yes	1	0	8
2	R:R:W387	R:R:Y390	34.1396	7.72	Yes	Yes	1	8	8
3	R:R:L43	R:R:W387	24.3723	11.39	No	Yes	0	7	8
4	R:R:L43	R:R:T39	17.6465	2.95	No	No	0	7	5
5	R:R:L90	R:R:Y390	45.642	7.03	Yes	Yes	0	8	8
6	R:R:L90	R:R:S86	43.9886	4.5	Yes	No	0	8	8
7	R:R:A50	R:R:S86	16.1564	3.42	No	No	0	8	8
8	R:R:A50	R:R:L394	13.513	3.15	No	No	0	8	7
9	L:L:?1	R:R:W358	88.1098	4.51	Yes	Yes	1	0	8
10	R:R:N392	R:R:W358	93.5497	13.56	No	Yes	0	9	8
11	R:R:N392	R:R:N396	93.4272	12.26	No	Yes	0	9	9
12	R:R:D82	R:R:N396	36.4156	9.42	Yes	Yes	2	9	9
13	R:R:D82	R:R:N54	88.7222	6.73	Yes	No	0	9	9
14	R:R:N54	R:R:P397	74.5969	6.52	No	No	0	9	9
15	R:R:P397	R:R:Y402	72.7393	2.78	No	Yes	0	9	6
16	R:R:L83	R:R:N54	17.279	5.49	Yes	No	0	8	9
17	R:R:V57	R:R:Y402	13.8498	5.05	No	Yes	0	9	6
18	R:R:F411	R:R:Y402	45.7134	8.25	No	Yes	0	8	6
19	R:R:F407	R:R:F411	37.0994	5.36	Yes	No	0	8	8
20	R:R:F407	R:R:L67	12.4413	8.53	Yes	No	0	8	8
21	R:R:L78	R:R:N396	45.693	9.61	Yes	Yes	2	9	9
22	R:R:H126	R:R:L78	70.6573	7.71	Yes	Yes	2	8	9
23	R:R:H126	R:R:T160	46.8565	15.06	Yes	No	0	8	8
24	R:R:A129	R:R:T160	44.0804	1.68	No	No	0	8	8
25	R:R:A129	R:R:L156	41.2839	3.15	No	No	0	8	6
26	R:R:L156	R:R:L74	38.467	4.15	No	No	0	6	8
27	R:R:D133	R:R:L74	32.772	5.43	No	No	0	9	8
28	R:R:D133	R:R:R148	29.8939	9.53	No	No	0	9	8
29	R:R:R148	R:R:V70	21.137	11.77	No	No	0	8	7
30	R:R:P150	R:R:V70	18.1772	3.53	No	No	0	5	7
31	R:R:L127	R:R:N396	12.6148	9.61	No	Yes	2	8	9
32	R:R:L78	R:R:Y400	55.0623	3.52	Yes	Yes	2	9	9
33	R:R:L127	R:R:Y400	11.2064	5.86	No	Yes	2	8	9
34	R:R:S393	R:R:S86	42.9169	3.26	No	No	0	9	8
35	L:L:?1	R:R:D116	38.9978	18.79	Yes	No	1	0	8
36	R:R:D116	R:R:V89	37.2627	7.3	No	No	1	8	8
37	R:R:F112	R:R:V89	100	3.93	No	No	0	6	8
38	R:R:V89	R:R:Y390	66.9218	3.79	No	Yes	1	8	8
39	R:R:F112	R:R:W102	91.386	6.01	No	Yes	0	6	9
40	R:R:L104	R:R:W102	32.2005	6.83	No	Yes	3	7	9
41	R:R:L104	R:R:T103	26.9341	4.42	No	No	0	7	5
42	R:R:L99	R:R:T103	10.8287	2.95	No	No	0	5	5
43	R:R:C187	R:R:W102	27.1892	5.22	Yes	Yes	3	9	9
44	R:R:K101	R:R:T103	10.8287	1.5	No	No	0	5	5
45	R:R:C109	R:R:W102	19.7898	5.22	No	Yes	3	9	9
46	R:R:C187	R:R:I113	24.9643	3.27	Yes	No	0	9	7
47	R:R:I113	R:R:I189	22.9026	5.89	No	No	0	7	6
48	R:R:H126	R:R:W161	14.8704	4.23	Yes	Yes	2	8	9
49	R:R:I124	R:R:W358	87.5995	9.4	No	Yes	0	8	8
50	R:R:I124	R:R:P207	74.454	3.39	No	Yes	0	8	9
51	R:R:I206	R:R:P207	78.4038	3.39	No	Yes	0	6	9
52	R:R:G202	R:R:I206	76.6075	1.76	No	No	0	5	6
53	R:R:G202	R:R:I167	74.9949	1.76	No	No	0	5	8
54	R:R:F354	R:R:I124	23.0966	5.02	Yes	No	0	9	8
55	R:R:F204	R:R:W358	38.0996	4.01	Yes	Yes	1	8	8
56	R:R:F204	R:R:F354	45.1215	7.5	Yes	Yes	1	8	9
57	L:L:?1	R:R:F362	25.6991	8.43	Yes	Yes	1	0	7
58	R:R:F204	R:R:F362	24.2396	19.29	Yes	Yes	1	8	7
59	R:R:C128	R:R:P207	38.9671	3.77	Yes	Yes	5	7	9
60	R:R:C128	R:R:L210	26.9239	4.76	Yes	No	0	7	7
61	R:R:F354	R:R:M211	56.5115	7.46	Yes	No	0	9	9
62	R:R:R134	R:R:Y400	46.2747	6.17	No	Yes	2	9	9
63	R:R:M211	R:R:M351	67.0953	4.33	No	No	0	9	8
64	R:R:M351	R:R:Y215	64.2376	3.59	No	Yes	0	8	9
65	R:R:L210	R:R:L214	24.8316	5.54	No	No	0	7	7
66	R:R:L132	R:R:L214	27.8118	4.15	No	No	0	6	7
67	R:R:L132	R:R:W136	25.1072	17.08	No	No	0	6	5
68	R:R:L214	R:R:Y135	21.2492	7.03	No	Yes	0	7	9
69	R:R:I218	R:R:Y215	30.0674	3.63	No	Yes	0	9	9
70	R:R:R152	R:R:W136	22.3719	5	No	No	0	7	5
71	R:R:D143	R:R:R152	19.7693	9.53	No	No	0	6	7
72	R:R:D143	R:R:K147	11.4207	8.3	No	No	0	6	5
73	R:R:I167	R:R:Y198	68.5242	3.63	No	Yes	0	8	5
74	R:R:I189	R:R:Y195	21.7493	3.63	No	Yes	0	6	8
75	R:R:Y195	R:R:Y198	54.603	3.97	Yes	Yes	4	8	5
76	R:R:D192	R:R:Y195	54.8173	3.45	No	Yes	0	6	8
77	R:R:D192	R:R:G194	52.4087	5.03	No	No	0	6	5
78	R:R:G194	R:R:H193	49.9796	1.59	No	No	0	5	4
79	R:R:F370	R:R:H193	47.5301	15.84	No	No	0	5	4
80	R:R:F370	R:R:P369	42.5699	4.33	No	Yes	0	5	7
81	R:R:K191	R:R:P369	11.0941	1.67	No	Yes	0	5	7
82	R:R:F204	R:R:Y205	11.3493	6.19	Yes	Yes	1	8	7
83	R:R:F204	R:R:L359	18.8304	8.53	Yes	Yes	0	8	7
84	R:R:L347	R:R:Y215	55.2562	4.69	No	Yes	0	8	9
85	R:R:I350	R:R:Y215	11.4717	7.25	No	Yes	0	8	9
86	R:R:F219	R:R:L347	51.6942	4.87	Yes	No	0	6	8
87	R:R:F219	R:R:R223	33.5783	5.34	Yes	No	0	6	7
88	R:R:E340	R:R:R223	26.1788	6.98	No	No	0	8	7
89	R:R:E340	R:R:R227	22.7291	13.96	No	No	0	8	6
90	R:R:I226	R:R:R227	15.2174	2.51	No	No	0	6	6
91	R:R:I399	R:R:Y400	23.7702	7.25	No	Yes	0	8	9
92	R:R:L368	R:R:P369	27.2403	1.64	No	Yes	0	4	7
93	R:R:L368	R:R:M377	13.8702	5.65	No	Yes	0	4	4
94	R:R:C375	R:R:L368	11.1349	1.59	No	No	0	4	4
95	R:R:F407	R:R:N404	12.4413	4.83	Yes	No	0	8	9
96	R:R:C109	R:R:D110	16.187	1.56	No	No	0	9	7
97	R:R:D110	R:R:M172	10.8083	1.39	No	No	0	7	6
98	R:R:D82	R:R:S393	43.713	4.42	Yes	No	0	9	9
99	R:R:C128	R:R:M211	20.79	3.24	Yes	No	0	7	9
100	R:R:R134	R:R:Y215	45.8767	6.17	No	Yes	0	9	9
101	R:R:I218	R:R:Y135	21.0043	3.63	No	Yes	0	9	9
102	R:R:D82	R:R:L78	55.3991	5.43	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D116	18.79	1	Yes	No	0	8	0	1
L:L:?1	R:R:V117	11.79	1	Yes	No	0	8	0	1
L:L:?1	R:R:C120	12.56	1	Yes	No	0	7	0	1
L:L:?1	R:R:W358	4.51	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F361	20.48	1	Yes	No	0	8	0	1
L:L:?1	R:R:F362	8.43	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Y390	11.6	1	Yes	Yes	0	8	0	1
R:R:D116	R:R:V89	7.3	1	No	No	8	8	1	2
R:R:V89	R:R:Y390	3.79	1	No	Yes	8	8	2	1
R:R:L90	R:R:Y390	7.03	0	Yes	Yes	8	8	2	1
R:R:A93	R:R:Y390	4	0	No	Yes	7	8	2	1
R:R:D116	R:R:Y390	12.64	1	No	Yes	8	8	1	1
R:R:S168	R:R:V117	3.23	0	No	No	8	8	2	1
R:R:C120	R:R:W358	3.92	1	No	Yes	7	8	1	1
R:R:I124	R:R:W358	9.4	0	No	Yes	8	8	2	1
R:R:F362	R:R:T200	3.89	1	Yes	Yes	7	7	1	2
R:R:F204	R:R:W358	4.01	1	Yes	Yes	8	8	2	1
R:R:F204	R:R:F362	19.29	1	Yes	Yes	8	7	2	1
R:R:F362	R:R:W358	7.02	1	Yes	Yes	7	8	1	1
R:R:G389	R:R:W358	7.04	0	No	Yes	8	8	2	1
R:R:N392	R:R:W358	13.56	0	No	Yes	9	8	2	1
R:R:F361	R:R:F362	6.43	1	No	Yes	8	7	1	1
R:R:F361	R:R:I385	3.77	1	No	No	8	6	1	2
R:R:N386	R:R:W387	3.39	1	No	Yes	7	8	2	2
R:R:N386	R:R:Y390	8.14	1	No	Yes	7	8	2	1
R:R:W387	R:R:Y390	7.72	1	Yes	Yes	8	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8W8B_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	258
Number of Links	282
Number of Hubs	32
Number of Links mediated by Hubs	139
Number of Communities	7
Number of Nodes involved in Communities	48
Number of Links involved in Communities	66

Path Summary
Number Of Nodes in MetaPath	103
Number Of Links MetaPath	102
Number of Shortest Paths	39193
Length Of Smallest Path	3
Average Path Length	12.6673
Length of Longest Path	32
Minimum Path Strength	1.19
Average Path Strength	6.01231
Maximum Path Strength	16.135
Minimum Path Correlation	0.7
Average Path Correlation	0.93685
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	58.471
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.8589
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • cation binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • signaling receptor binding • receptor-receptor interaction • tetrapyrrole binding • heme binding • electron transfer activity • transition metal ion binding • iron ion binding • metal ion binding • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • behavior • exploration behavior • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • regulation of tube diameter • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • gamma-aminobutyric acid signaling pathway • regulation of behavior • serotonin metabolic process • indole-containing compound metabolic process • serotonin receptor signaling pathway • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • monoatomic ion transport • serotonin secretion • regulation of monoatomic ion transport • regulation of serotonin secretion • serotonin transport • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • electron transport chain • generation of precursor metabolites and energy • somatodendritic compartment • dendrite • dendritic tree • periplasmic space
SCOP2	Domain Identifier	• Ras-like P-loop GTPases
SCOP2	Family Identifier	• Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	UJL
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	UJL
Name	SEP-363856
Synonyms	Ulotaront; SEP-363856; SEP-856
Identifier
Formula	C9 H13 N O S
Molecular Weight	183.271
SMILES
PubChem	89532783
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	1
Total Bonds	26
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08908
Sequence	>8W8B_nogp_Chain_R Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E R S L Q N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N K W T L G Q V T C D L F I A L D V L C C T S S I W H L C A I A L D R Y W A I T D P I D Y V N K R T P R R A A A L I S L T W L I G F L I S I P P M L G W P D A C T I S K D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C E S S C H M P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F Q N A F K K I I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7E2X	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2X (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-	Gi1/β1/γ2	3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-		3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	8W8B	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-	Gi1/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8B (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8JSP	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-	Gi1/β1/γ2	3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSP (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-		3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8FY8	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-	Gi1/β1/γ1	2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FY8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-		2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-	Gi1/β1/γ1	2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-		2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-	Gi1/β1/γ1	2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-		2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-	Gi1/β1/γ1	2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-		2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gi1/β1/γ1	2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8JT6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-	Gi1/β1/γ2	3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8JT6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-		3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8PJK	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-	Gi1/β1/γ1	2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PJK (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-		2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gi1/β1/γ1	2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	9GL2	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gs/β1/γ2	3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9GL2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9DYF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-	Gi1/β1/γ2	2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-		2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-	Go/β1/γ2	2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-		2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Go/β1/γ2	2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851

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