psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:A93	3.09	Yes	No	0	0	7
2	L:L:?1	R:R:W102	4.47	Yes	Yes	1	0	9
3	L:L:?1	R:R:D116	20.41	Yes	Yes	1	0	8
4	L:L:?1	R:R:V117	8.77	Yes	No	0	0	8
5	L:L:?1	R:R:C120	3.11	Yes	No	1	0	7
6	L:L:?1	R:R:C187	4.15	Yes	Yes	1	0	9
7	L:L:?1	R:R:F361	15.93	Yes	Yes	1	0	8
8	L:L:?1	R:R:F362	5.57	Yes	Yes	1	0	7
9	L:L:?1	R:R:N386	8.98	Yes	No	0	0	7
10	L:L:?1	R:R:Y390	11.5	Yes	Yes	1	0	8
11	R:R:Q36	R:R:V98	5.73	No	Yes	0	4	6
12	R:R:S40	R:R:V98	3.23	No	Yes	0	5	6
13	R:R:A94	R:R:L43	3.15	No	No	0	7	7
14	R:R:L43	R:R:W387	13.67	No	Yes	0	7	8
15	R:R:I47	R:R:L90	2.85	No	Yes	0	7	8
16	R:R:A50	R:R:S86	3.42	No	No	0	8	8
17	R:R:A50	R:R:L394	3.15	No	No	0	8	7
18	R:R:L83	R:R:V51	2.98	Yes	No	0	8	7
19	R:R:G53	R:R:Y402	2.9	No	Yes	0	9	6
20	R:R:D82	R:R:N54	4.04	Yes	Yes	0	9	9
21	R:R:N54	R:R:S86	2.98	Yes	No	0	9	8
22	R:R:N54	R:R:P397	6.52	Yes	No	0	9	9
23	R:R:A79	R:R:V57	3.39	No	Yes	0	9	9
24	R:R:A401	R:R:V57	3.39	No	Yes	0	8	9
25	R:R:V57	R:R:Y402	3.79	Yes	Yes	0	9	6
26	R:R:V58	R:R:V80	3.21	No	No	0	7	7
27	R:R:A60	R:R:F411	4.16	No	No	0	8	8
28	R:R:F407	R:R:I61	5.02	Yes	No	0	8	8
29	R:R:I414	R:R:L63	4.28	No	No	0	7	6
30	R:R:A410	R:R:E64	4.53	No	No	0	8	7
31	R:R:E64	R:R:K413	8.1	No	No	0	7	6
32	R:R:E64	R:R:I414	6.83	No	No	0	7	7
33	R:R:Q68	R:R:R65	9.35	No	No	0	8	7
34	R:R:L67	R:R:N72	4.12	Yes	No	3	8	9
35	R:R:F407	R:R:L67	8.53	Yes	Yes	3	8	8
36	R:R:A410	R:R:L67	3.15	No	Yes	0	8	8
37	R:R:Q68	R:R:Y73	4.51	No	No	0	8	6
38	R:R:A71	R:R:N69	4.69	No	No	0	8	8
39	R:R:N69	R:R:N72	8.17	No	No	0	8	9
40	R:R:R148	R:R:V70	7.85	Yes	No	0	8	7
41	R:R:P150	R:R:V70	3.53	No	No	0	5	7
42	R:R:F407	R:R:N72	10.87	Yes	No	3	8	9
43	R:R:P150	R:R:Y73	4.17	No	No	0	5	6
44	R:R:D133	R:R:L74	4.07	No	No	0	9	8
45	R:R:I157	R:R:L74	2.85	No	No	0	8	8
46	R:R:H126	R:R:S77	6.97	Yes	No	0	8	9
47	R:R:I157	R:R:S77	10.84	No	No	0	8	9
48	R:R:D82	R:R:L78	5.43	Yes	No	2	9	9
49	R:R:H126	R:R:L78	6.43	Yes	No	2	8	9
50	R:R:L78	R:R:N396	4.12	No	Yes	2	9	9
51	R:R:S122	R:R:T81	6.4	No	No	2	8	9
52	R:R:H126	R:R:T81	5.48	Yes	No	2	8	9
53	R:R:T81	R:R:W161	8.49	No	Yes	2	9	9
54	R:R:D82	R:R:S123	5.89	Yes	No	0	9	9
55	R:R:D82	R:R:S393	5.89	Yes	No	0	9	9
56	R:R:D82	R:R:N396	6.73	Yes	Yes	2	9	9
57	R:R:L83	R:R:V87	2.98	Yes	No	0	8	6
58	R:R:M84	R:R:W161	3.49	No	Yes	0	7	9
59	R:R:L90	R:R:V85	2.98	Yes	No	0	8	8
60	R:R:C119	R:R:V85	3.42	No	No	0	7	8
61	R:R:S393	R:R:V85	3.23	No	No	0	9	8
62	R:R:L90	R:R:S86	3	Yes	No	0	8	8
63	R:R:D116	R:R:V89	5.84	Yes	No	0	8	8
64	R:R:L90	R:R:Y390	5.86	Yes	Yes	0	8	8
65	R:R:F112	R:R:M92	7.46	No	No	0	6	6
66	R:R:L95	R:R:L99	4.15	No	No	0	6	5
67	R:R:W102	R:R:Y96	8.68	Yes	No	0	9	6
68	R:R:A383	R:R:Q97	4.55	No	No	0	6	7
69	R:R:Q97	R:R:W387	4.38	No	Yes	0	7	8
70	R:R:D185	R:R:K101	5.53	No	No	0	4	5
71	R:R:L104	R:R:W102	11.39	No	Yes	0	7	9
72	R:R:C109	R:R:W102	3.92	No	Yes	1	9	9
73	R:R:C187	R:R:W102	9.14	Yes	Yes	1	9	9
74	R:R:L104	R:R:T108	7.37	No	No	0	7	6
75	R:R:C109	R:R:I113	3.27	No	No	1	9	7
76	R:R:C109	R:R:C187	7.28	No	Yes	1	9	9
77	R:R:D110	R:R:M172	8.32	No	No	0	7	6
78	R:R:D110	R:R:R181	10.72	No	No	0	7	4
79	R:R:C187	R:R:I113	3.27	Yes	No	1	9	7
80	R:R:A114	R:R:M172	3.22	No	No	0	7	6
81	R:R:C120	R:R:D116	3.11	No	Yes	1	7	8
82	R:R:D116	R:R:Y390	8.05	Yes	Yes	1	8	8
83	R:R:S168	R:R:V117	3.23	No	No	0	8	8
84	R:R:L118	R:R:W161	6.83	No	Yes	0	6	9
85	R:R:F165	R:R:L118	10.96	No	No	0	5	6
86	R:R:L118	R:R:S168	3	No	No	0	6	8
87	R:R:C120	R:R:W358	5.22	No	Yes	1	7	8
88	R:R:G164	R:R:T121	3.64	No	No	0	8	8
89	R:R:I167	R:R:T121	6.08	No	No	0	8	8
90	R:R:A203	R:R:T121	3.36	No	No	0	8	8
91	R:R:S122	R:R:T160	3.2	No	Yes	2	8	8
92	R:R:S122	R:R:W161	18.53	No	Yes	2	8	9
93	R:R:I124	R:R:P207	3.39	No	No	0	8	9
94	R:R:F354	R:R:I124	3.77	Yes	No	1	9	8
95	R:R:I124	R:R:W358	9.4	No	Yes	1	8	8
96	R:R:I163	R:R:W125	15.27	No	No	0	5	7
97	R:R:P207	R:R:W125	10.81	No	No	0	9	7
98	R:R:H126	R:R:T160	12.32	Yes	Yes	2	8	8
99	R:R:H126	R:R:W161	3.17	Yes	Yes	2	8	9
100	R:R:L127	R:R:N396	6.87	No	Yes	0	8	9
101	R:R:L127	R:R:Y400	4.69	No	Yes	0	8	9
102	R:R:C128	R:R:M211	4.86	No	Yes	0	7	9
103	R:R:I130	R:R:R134	5.01	No	No	5	9	9
104	R:R:I130	R:R:Y400	6.04	No	Yes	5	9	9
105	R:R:A131	R:R:Y215	6.67	No	Yes	0	9	9
106	R:R:L132	R:R:W136	14.81	No	No	0	6	5
107	R:R:L132	R:R:L214	4.15	No	No	0	6	7
108	R:R:D133	R:R:R148	7.15	No	Yes	0	9	8
109	R:R:R134	R:R:Y215	5.14	No	Yes	0	9	9
110	R:R:R134	R:R:Y400	4.12	No	Yes	5	9	9
111	R:R:W136	R:R:Y135	2.89	No	Yes	0	5	9
112	R:R:T139	R:R:Y135	13.73	No	Yes	0	8	9
113	R:R:L214	R:R:Y135	5.86	No	Yes	0	7	9
114	R:R:R217	R:R:Y135	11.32	No	Yes	0	7	9
115	R:R:I218	R:R:Y135	3.63	No	Yes	0	9	9
116	R:R:R152	R:R:W136	5	No	No	0	7	5
117	R:R:I138	R:R:T139	3.04	No	No	0	9	8
118	R:R:D140	R:R:P141	3.22	No	No	0	7	8
119	R:R:D140	R:R:D143	6.65	No	No	0	7	6
120	R:R:I142	R:R:N146	4.25	No	No	0	6	5
121	R:R:D143	R:R:K147	4.15	No	No	0	6	5
122	R:R:D143	R:R:R152	10.72	No	No	0	6	7
123	R:R:R148	R:R:Y144	8.23	Yes	No	0	8	8
124	R:R:N146	R:R:V145	4.43	No	No	0	5	6
125	R:R:K147	R:R:N146	5.6	No	No	0	5	5
126	R:R:R148	R:R:R152	7.46	Yes	No	0	8	7
127	R:R:P150	R:R:T149	3.5	No	No	0	5	8
128	R:R:T160	R:R:W161	4.85	Yes	Yes	2	8	9
129	R:R:I167	R:R:Y198	3.63	No	No	0	8	5
130	R:R:I169	R:R:P170	5.08	No	Yes	0	6	8
131	R:R:P170	R:R:P171	5.84	Yes	No	0	8	7
132	R:R:P170	R:R:W175	8.11	Yes	No	0	8	6
133	R:R:P170	R:R:Y198	5.56	Yes	No	0	8	5
134	R:R:P171	R:R:Y195	16.69	No	Yes	0	7	8
135	R:R:W175	R:R:Y195	4.82	No	Yes	0	6	8
136	R:R:D180	R:R:R176	17.87	Yes	No	6	4	6
137	R:R:R176	R:R:R181	9.6	No	No	0	6	4
138	R:R:R176	R:R:S190	6.59	No	No	6	6	6
139	R:R:D180	R:R:T177	5.78	Yes	No	0	4	5
140	R:R:D192	R:R:T177	4.34	No	No	0	6	5
141	R:R:D180	R:R:S190	2.94	Yes	No	6	4	6
142	R:R:D183	R:R:P184	6.44	No	No	4	1	1
143	R:R:D183	R:R:D185	6.65	No	No	4	1	4
144	R:R:A186	R:R:D183	4.63	No	No	0	4	1
145	R:R:D185	R:R:P184	4.83	No	No	4	4	1
146	R:R:I189	R:R:K191	2.91	No	No	0	6	5
147	R:R:I189	R:R:Y195	3.63	No	Yes	0	6	8
148	R:R:D192	R:R:G194	3.35	No	No	0	6	5
149	R:R:D192	R:R:Y195	3.45	No	Yes	0	6	8
150	R:R:F370	R:R:H193	14.71	No	No	0	5	4
151	R:R:E372	R:R:H193	4.92	No	No	0	3	4
152	R:R:S199	R:R:Y195	7.63	No	Yes	0	8	8
153	R:R:P369	R:R:T196	10.49	No	No	0	7	7
154	R:R:F201	R:R:I197	3.77	No	No	0	5	7
155	R:R:F370	R:R:I197	5.02	No	No	0	5	7
156	R:R:F201	R:R:T200	3.89	No	No	0	5	7
157	R:R:L366	R:R:T200	7.37	No	No	0	7	7
158	R:R:F201	R:R:Y205	8.25	No	No	0	5	7
159	R:R:F204	R:R:Y205	6.19	Yes	No	0	8	7
160	R:R:F204	R:R:F354	5.36	Yes	Yes	1	8	9
161	R:R:F204	R:R:W358	3.01	Yes	Yes	1	8	8
162	R:R:F204	R:R:L359	6.09	Yes	Yes	0	8	7
163	R:R:F204	R:R:F362	18.22	Yes	Yes	1	8	7
164	R:R:L366	R:R:Y205	4.69	No	No	0	7	7
165	R:R:I206	R:R:P207	3.39	No	No	0	6	9
166	R:R:F354	R:R:L208	3.65	Yes	No	0	9	7
167	R:R:I355	R:R:L208	2.85	No	No	0	7	7
168	R:R:L210	R:R:L214	4.15	No	No	0	7	7
169	R:R:M211	R:R:Y215	3.59	Yes	Yes	0	9	9
170	R:R:M211	R:R:M351	4.33	Yes	No	0	9	8
171	R:R:F354	R:R:M211	3.73	Yes	Yes	0	9	9
172	R:R:R217	R:R:V213	5.23	No	No	0	7	5
173	R:R:I218	R:R:Y215	3.63	No	Yes	0	9	9
174	R:R:L347	R:R:Y215	4.69	No	Yes	0	8	9
175	R:R:F219	R:R:R223	11.76	Yes	No	0	6	7
176	R:R:F219	R:R:T343	5.19	Yes	No	0	6	8
177	R:R:F219	R:R:L347	3.65	Yes	No	0	6	8
178	R:R:R223	R:R:R227	5.33	No	No	7	7	6
179	R:R:E340	R:R:R223	15.12	Yes	No	7	8	7
180	R:R:F224	R:R:K228	3.72	No	No	0	6	5
181	R:R:I226	R:R:R339	3.76	No	No	0	6	7
182	R:R:E340	R:R:I226	6.83	Yes	No	0	8	6
183	R:R:I226	R:R:T343	3.04	No	No	0	6	8
184	R:R:E340	R:R:R227	10.47	Yes	No	7	8	6
185	R:R:E326	R:R:R327	8.14	No	No	0	3	3
186	R:R:E326	R:R:E330	6.34	No	No	0	3	4
187	R:R:K332	R:R:N328	8.39	No	No	0	6	3
188	R:R:E330	R:R:R333	3.49	No	No	0	4	4
189	R:R:M335	R:R:R339	8.69	No	No	0	4	7
190	R:R:I349	R:R:K345	5.82	No	No	0	7	7
191	R:R:I349	R:R:I399	2.94	No	No	0	7	8
192	R:R:I355	R:R:M351	2.92	No	No	0	7	8
193	R:R:L395	R:R:T353	2.95	No	No	0	6	7
194	R:R:I399	R:R:T353	4.56	No	No	0	8	7
195	R:R:F354	R:R:W358	3.01	Yes	Yes	1	9	8
196	R:R:I355	R:R:L359	4.28	No	Yes	0	7	7
197	R:R:C357	R:R:N392	11.02	No	No	0	8	9
198	R:R:F361	R:R:W358	5.01	Yes	Yes	1	8	8
199	R:R:F362	R:R:W358	5.01	Yes	Yes	1	7	8
200	R:R:G389	R:R:W358	5.63	No	Yes	0	8	8
201	R:R:N392	R:R:W358	9.04	No	Yes	0	9	8
202	R:R:L359	R:R:P360	3.28	Yes	No	0	7	9
203	R:R:I363	R:R:L359	5.71	No	Yes	0	7	7
204	R:R:F361	R:R:F362	11.79	Yes	Yes	1	8	7
205	R:R:A365	R:R:F361	4.16	No	Yes	0	8	8
206	R:R:L368	R:R:V364	4.47	No	No	0	4	6
207	R:R:I385	R:R:V364	4.61	No	No	0	6	6
208	R:R:C375	R:R:L368	3.17	No	No	0	4	4
209	R:R:L368	R:R:M377	5.65	No	No	0	4	4
210	R:R:M377	R:R:P378	6.71	No	No	0	4	7
211	R:R:L381	R:R:M377	4.24	No	No	0	6	4
212	R:R:I384	R:R:L380	7.14	No	No	0	4	3
213	R:R:G382	R:R:I385	3.53	No	No	0	4	6
214	R:R:W387	R:R:Y390	9.65	Yes	Yes	0	8	8
215	R:R:N392	R:R:N396	10.9	No	Yes	0	9	9
216	R:R:V398	R:R:Y402	3.79	No	Yes	0	6	6
217	R:R:I399	R:R:Y400	3.63	No	Yes	0	8	9
218	R:R:F411	R:R:Y402	6.19	No	Yes	0	8	6
219	R:R:F407	R:R:N404	13.29	Yes	No	0	8	9
220	R:R:K412	R:R:N409	4.2	No	No	0	6	6
221	R:R:I414	R:R:I415	4.42	No	No	0	7	7
222	R:R:L212	R:R:M351	2.83	No	No	0	6	8
223	R:R:I385	R:R:N386	2.83	No	No	0	6	7
224	R:R:G174	R:R:W175	2.81	No	No	0	5	6
225	R:R:C56	R:R:F411	2.79	No	No	0	8	8
226	R:R:L156	R:R:L74	2.77	No	No	0	6	8
227	R:R:L115	R:R:L88	2.77	No	No	0	5	6
228	R:R:L162	R:R:L166	2.77	No	No	0	5	5
229	R:R:A203	R:R:F362	2.77	No	Yes	0	8	7
230	R:R:L83	R:R:N54	2.75	Yes	Yes	0	8	9
231	R:R:K405	R:R:Q408	2.71	No	No	0	6	9
232	R:R:F407	R:R:V57	2.62	Yes	Yes	0	8	9
233	R:R:F219	R:R:V344	2.62	Yes	No	0	6	8
234	R:R:F403	R:R:V398	2.62	No	No	0	8	6
235	R:R:F112	R:R:T108	2.59	No	No	0	6	6
236	R:R:K228	R:R:R225	2.48	No	No	0	5	7
237	R:R:F48	R:R:L52	2.44	No	No	0	4	4
238	R:R:I350	R:R:Y215	2.42	No	Yes	0	8	9
239	R:R:L46	R:R:W387	2.28	No	Yes	0	7	8
240	R:R:R217	R:R:R220	2.13	No	No	0	7	5
241	R:R:A79	R:R:G76	1.95	No	No	0	9	6
242	R:R:C371	R:R:C375	1.82	No	No	0	5	4
243	R:R:P397	R:R:V57	1.77	No	Yes	0	9	9
244	R:R:G44	R:R:I47	1.76	No	No	0	4	7
245	R:R:G202	R:R:I167	1.76	No	No	0	5	8
246	R:R:P178	R:R:T177	1.75	No	No	0	5	5
247	R:R:C357	R:R:S391	1.72	No	No	0	8	5
248	R:R:C371	R:R:S374	1.72	No	No	0	5	5
249	R:R:G53	R:R:L52	1.71	No	No	0	9	4
250	R:R:A79	R:R:V58	1.7	No	No	0	9	7
251	R:R:A153	R:R:V70	1.7	No	No	0	7	7
252	R:R:C49	R:R:T45	1.69	No	No	0	5	4
253	R:R:I47	R:R:P91	1.69	No	No	0	7	9
254	R:R:A129	R:R:T160	1.68	No	Yes	0	8	8
255	R:R:A221	R:R:T139	1.68	No	No	0	6	8
256	R:R:A222	R:R:T343	1.68	No	No	0	8	8
257	R:R:K191	R:R:P369	1.67	No	No	0	5	7
258	R:R:A401	R:R:I75	1.62	No	No	0	8	8
259	R:R:T39	R:R:V98	1.59	No	Yes	0	5	6
260	R:R:C49	R:R:L394	1.59	No	No	0	5	7
261	R:R:A55	R:R:L83	1.58	No	Yes	0	5	8
262	R:R:E179	R:R:P178	1.57	No	No	0	3	5
263	R:R:I363	R:R:V367	1.54	No	No	0	7	6
264	R:R:I350	R:R:T346	1.52	No	No	0	8	8
265	R:R:F219	R:R:G216	1.51	Yes	No	0	6	3
266	R:R:A336	R:R:E340	1.51	No	Yes	0	5	8
267	R:R:K101	R:R:T103	1.5	No	No	0	5	5
268	R:R:L159	R:R:S158	1.5	No	No	0	3	5
269	R:R:K342	R:R:T346	1.5	No	No	0	8	8
270	R:R:L388	R:R:S391	1.5	No	No	0	8	5
271	R:R:L41	R:R:V37	1.49	No	No	0	4	5
272	R:R:L88	R:R:V89	1.49	No	No	0	6	8
273	R:R:L99	R:R:V98	1.49	No	Yes	0	5	6
274	R:R:L99	R:R:T103	1.47	No	No	0	5	5
275	R:R:D180	R:R:T188	1.45	Yes	No	0	4	5
276	R:R:I38	R:R:L42	1.43	No	No	0	3	5
277	R:R:L95	R:R:M92	1.41	No	No	0	6	6
278	R:R:A137	R:R:R148	1.38	No	Yes	0	8	8
279	R:R:L159	R:R:L162	1.38	No	No	0	3	5
280	R:R:L356	R:R:L388	1.38	No	No	0	5	8
281	R:R:D406	R:R:L67	1.36	No	Yes	0	7	8
282	R:R:N325	R:R:N328	1.36	No	No	0	5	3
283	R:R:K412	R:R:Q408	1.36	No	No	0	6	9
284	R:R:D406	R:R:N409	1.35	No	No	0	7	6
285	R:R:R151	R:R:T149	1.29	No	No	0	6	8
286	R:R:L337	R:R:R333	1.21	No	No	0	5	4
287	R:R:L166	R:R:Y198	1.17	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.598	10	1	0
2	R:R:N54	4.0725	4	0	9
3	R:R:V57	2.992	5	0	9
4	R:R:L67	4.29	4	3	8
5	R:R:D82	5.596	5	2	9
6	R:R:L83	2.5725	4	0	8
7	R:R:L90	3.6725	4	0	8
8	R:R:V98	3.01	4	0	6
9	R:R:W102	7.52	5	1	9
10	R:R:D116	9.3525	4	1	8
11	R:R:H126	6.874	5	2	8
12	R:R:Y135	7.486	5	0	9
13	R:R:R148	6.414	5	0	8
14	R:R:T160	5.5125	4	2	8
15	R:R:W161	7.56	6	2	9
16	R:R:P170	6.1475	4	0	8
17	R:R:D180	7.01	4	6	4
18	R:R:C187	5.96	4	1	9
19	R:R:Y195	7.244	5	0	8
20	R:R:F204	7.774	5	1	8
21	R:R:M211	4.1275	4	0	9
22	R:R:Y215	4.35667	6	0	9
23	R:R:F219	4.946	5	0	6
24	R:R:E340	8.4825	4	7	8
25	R:R:F354	3.904	5	1	9
26	R:R:W358	5.66625	8	1	8
27	R:R:L359	4.84	4	0	7
28	R:R:F361	9.2225	4	1	8
29	R:R:F362	8.672	5	1	7
30	R:R:W387	7.495	4	0	8
31	R:R:Y390	8.765	4	1	8
32	R:R:N396	7.155	4	2	9
33	R:R:Y400	4.62	4	5	9
34	R:R:Y402	4.1675	4	0	6
35	R:R:F407	8.066	5	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W102	46.9188	4.47	Yes	Yes	1	0	9
2	R:R:L104	R:R:W102	40.0377	11.39	No	Yes	0	7	9
3	R:R:L104	R:R:T108	37.6115	7.37	No	No	0	7	6
4	R:R:F112	R:R:T108	35.1751	2.59	No	No	0	6	6
5	R:R:F112	R:R:M92	32.7285	7.46	No	No	0	6	6
6	R:R:L95	R:R:M92	30.2717	1.41	No	No	0	6	6
7	R:R:L95	R:R:L99	27.8047	4.15	No	No	0	6	5
8	R:R:L99	R:R:V98	10.2503	1.49	No	Yes	0	5	6
9	L:L:?1	R:R:Y390	47.8822	11.5	Yes	Yes	1	0	8
10	R:R:W387	R:R:Y390	18.9561	9.65	Yes	Yes	0	8	8
11	R:R:L90	R:R:Y390	39.5841	5.86	Yes	Yes	0	8	8
12	R:R:L90	R:R:S86	30.1544	3	Yes	No	0	8	8
13	R:R:N54	R:R:S86	28.8292	2.98	Yes	No	0	9	8
14	R:R:N54	R:R:P397	52.8009	6.52	Yes	No	0	9	9
15	R:R:P397	R:R:V57	51.4654	1.77	No	Yes	0	9	9
16	R:R:V57	R:R:Y402	14.7663	3.79	Yes	Yes	0	9	6
17	L:L:?1	R:R:C120	20.8166	3.11	Yes	No	1	0	7
18	R:R:C120	R:R:W358	27.5549	5.22	No	Yes	1	7	8
19	R:R:N392	R:R:W358	43.3712	9.04	No	Yes	0	9	8
20	R:R:N392	R:R:N396	38.5799	10.9	No	Yes	0	9	9
21	R:R:D82	R:R:N396	33.4268	6.73	Yes	Yes	2	9	9
22	L:L:?1	R:R:F361	21.0816	15.93	Yes	Yes	1	0	8
23	R:R:F361	R:R:W358	21.5352	5.01	Yes	Yes	1	8	8
24	L:L:?1	R:R:F362	69.6417	5.57	Yes	Yes	1	0	7
25	R:R:F362	R:R:W358	56.6033	5.01	Yes	Yes	1	7	8
26	R:R:D82	R:R:N54	40.4506	4.04	Yes	Yes	0	9	9
27	R:R:F407	R:R:V57	28.712	2.62	Yes	Yes	0	8	9
28	R:R:F407	R:R:L67	19.3231	8.53	Yes	Yes	3	8	8
29	L:L:?1	R:R:V117	14.0629	8.77	Yes	No	0	0	8
30	R:R:S168	R:R:V117	12.1566	3.23	No	No	0	8	8
31	R:R:L118	R:R:S168	10.7702	3	No	No	0	6	8
32	R:R:H126	R:R:S77	17.427	6.97	Yes	No	0	8	9
33	R:R:I157	R:R:S77	16.3107	10.84	No	No	0	8	9
34	R:R:I157	R:R:L74	15.2811	2.85	No	No	0	8	8
35	R:R:D133	R:R:L74	13.4767	4.07	No	No	0	9	8
36	R:R:D133	R:R:R148	12.7529	7.15	No	Yes	0	9	8
37	R:R:R148	R:R:V70	20.9542	7.85	Yes	No	0	8	7
38	R:R:P150	R:R:V70	15.7755	3.53	No	No	0	5	7
39	R:R:F354	R:R:W358	67.9545	3.01	Yes	Yes	1	9	8
40	R:R:F354	R:R:M211	100	3.73	Yes	Yes	0	9	9
41	R:R:M211	R:R:Y215	93.6184	3.59	Yes	Yes	0	9	9
42	R:R:I218	R:R:Y215	65.2327	3.63	No	Yes	0	9	9
43	R:R:I218	R:R:Y135	63.1021	3.63	No	Yes	0	9	9
44	R:R:W136	R:R:Y135	41.7402	2.89	No	Yes	0	5	9
45	R:R:R152	R:R:W136	37.953	5	No	No	0	7	5
46	R:R:R148	R:R:R152	25.7047	7.46	Yes	No	0	8	7
47	R:R:F204	R:R:F362	40.471	18.22	Yes	Yes	1	8	7
48	R:R:F204	R:R:F354	35.0782	5.36	Yes	Yes	1	8	9
49	R:R:L99	R:R:T103	15.3168	1.47	No	No	0	5	5
50	R:R:K101	R:R:T103	12.7886	1.5	No	No	0	5	5
51	R:R:D185	R:R:K101	10.2503	5.53	No	No	0	4	5
52	R:R:A203	R:R:F362	86.3704	2.77	No	Yes	0	8	7
53	R:R:A203	R:R:T121	85.0043	3.36	No	No	0	8	8
54	R:R:I167	R:R:T121	82.2417	6.08	No	No	0	8	8
55	R:R:I167	R:R:Y198	79.5097	3.63	No	No	0	8	5
56	R:R:P170	R:R:Y198	72.3177	5.56	Yes	No	0	8	5
57	R:R:P170	R:R:P171	33.8498	5.84	Yes	No	0	8	7
58	R:R:P171	R:R:Y195	32.2544	16.69	No	Yes	0	7	8
59	R:R:D192	R:R:Y195	44.5894	3.45	No	Yes	0	6	8
60	R:R:D192	R:R:T177	37.8409	4.34	No	No	0	6	5
61	R:R:D180	R:R:T177	27.6416	5.78	Yes	No	0	4	5
62	R:R:D180	R:R:R176	17.325	17.87	Yes	No	6	4	6
63	R:R:R176	R:R:R181	13.8998	9.6	No	No	0	6	4
64	R:R:D110	R:R:R181	10.4389	10.72	No	No	0	7	4
65	R:R:P170	R:R:W175	35.5421	8.11	Yes	No	0	8	6
66	R:R:W175	R:R:Y195	32.3513	4.82	No	Yes	0	6	8
67	R:R:L127	R:R:N396	23.202	6.87	No	Yes	0	8	9
68	R:R:L127	R:R:Y400	21.8462	4.69	No	Yes	0	8	9
69	R:R:R134	R:R:Y215	16.6216	5.14	No	Yes	0	9	9
70	R:R:D143	R:R:R152	17.2231	10.72	No	No	0	6	7
71	R:R:I189	R:R:Y195	13.8998	3.63	No	Yes	0	6	8
72	R:R:I189	R:R:K191	10.4389	2.91	No	No	0	6	5
73	R:R:F204	R:R:Y205	12.9517	6.19	Yes	No	0	8	7
74	R:R:L347	R:R:Y215	31.286	4.69	No	Yes	0	8	9
75	R:R:F219	R:R:L347	28.9107	3.65	Yes	No	0	6	8
76	R:R:F219	R:R:T343	12.1719	5.19	Yes	No	0	6	8
77	R:R:I399	R:R:Y400	10.1636	3.63	No	Yes	0	8	9
78	L:L:?1	R:R:N386	27.7384	8.98	Yes	No	0	0	7
79	R:R:I385	R:R:N386	25.3275	2.83	No	No	0	6	7
80	R:R:I385	R:R:V364	20.3425	4.61	No	No	0	6	6
81	R:R:L368	R:R:V364	17.8348	4.47	No	No	0	4	6
82	R:R:H126	R:R:L78	20.0826	6.43	Yes	No	2	8	9
83	R:R:D82	R:R:L78	12.0699	5.43	Yes	No	2	9	9
84	R:R:R134	R:R:Y400	13.1964	4.12	No	Yes	5	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:A93	3.09	1	Yes	No	0	7	0	1
L:L:?1	R:R:W102	4.47	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:D116	20.41	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:V117	8.77	1	Yes	No	0	8	0	1
L:L:?1	R:R:C120	3.11	1	Yes	No	0	7	0	1
L:L:?1	R:R:C187	4.15	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F361	15.93	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F362	5.57	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N386	8.98	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y390	11.5	1	Yes	Yes	0	8	0	1
R:R:D116	R:R:V89	5.84	1	Yes	No	8	8	1	2
R:R:L90	R:R:Y390	5.86	0	Yes	Yes	8	8	2	1
R:R:W102	R:R:Y96	8.68	1	Yes	No	9	6	1	2
R:R:L104	R:R:W102	11.39	0	No	Yes	7	9	2	1
R:R:C109	R:R:W102	3.92	1	No	Yes	9	9	2	1
R:R:C187	R:R:W102	9.14	1	Yes	Yes	9	9	1	1
R:R:C109	R:R:I113	3.27	1	No	No	9	7	2	2
R:R:C109	R:R:C187	7.28	1	No	Yes	9	9	2	1
R:R:C187	R:R:I113	3.27	1	Yes	No	9	7	1	2
R:R:C120	R:R:D116	3.11	1	No	Yes	7	8	1	1
R:R:D116	R:R:Y390	8.05	1	Yes	Yes	8	8	1	1
R:R:S168	R:R:V117	3.23	0	No	No	8	8	2	1
R:R:C120	R:R:W358	5.22	1	No	Yes	7	8	1	2
R:R:F204	R:R:W358	3.01	1	Yes	Yes	8	8	2	2
R:R:F204	R:R:F362	18.22	1	Yes	Yes	8	7	2	1
R:R:F361	R:R:W358	5.01	1	Yes	Yes	8	8	1	2
R:R:F362	R:R:W358	5.01	1	Yes	Yes	7	8	1	2
R:R:F361	R:R:F362	11.79	1	Yes	Yes	8	7	1	1
R:R:A365	R:R:F361	4.16	0	No	Yes	8	8	2	1
R:R:W387	R:R:Y390	9.65	0	Yes	Yes	8	8	2	1
R:R:I385	R:R:N386	2.83	0	No	No	6	7	2	1
R:R:A203	R:R:F362	2.77	0	No	Yes	8	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9DYE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	262
Number of Links	287
Number of Hubs	35
Number of Links mediated by Hubs	137
Number of Communities	7
Number of Nodes involved in Communities	37
Number of Links involved in Communities	51

Path Summary
Number Of Nodes in MetaPath	85
Number Of Links MetaPath	84
Number of Shortest Paths	54906
Length Of Smallest Path	3
Average Path Length	13.3442
Length of Longest Path	30
Minimum Path Strength	1.355
Average Path Strength	5.48408
Maximum Path Strength	15.005
Minimum Path Correlation	0.7
Average Path Correlation	0.937991
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	56.5578
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.8977
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • GABA-ergic synapse • glutamatergic synapse • cell body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • cation binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • signaling receptor binding • receptor-receptor interaction • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • behavior • exploration behavior • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • regulation of tube diameter • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • gamma-aminobutyric acid signaling pathway • regulation of behavior • serotonin metabolic process • indole-containing compound metabolic process • serotonin receptor signaling pathway • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • monoatomic ion transport • serotonin secretion • regulation of monoatomic ion transport • regulation of serotonin secretion • serotonin transport • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	YLX
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	YLX
Name	Buspirone
Synonyms	Buspirona
Identifier
Formula	C21 H31 N5 O2
Molecular Weight	385.503
SMILES
PubChem	2477
Formal Charge	0
Total Atoms	59
Total Chiral Atoms	0
Total Bonds	62
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08908
Sequence	>9DYE_nogp_Chain_R Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E R S L Q N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N K W T L G Q V T C D L F I A L D V L C C T S S I H L C A I A L D R Y W A I T D P I D Y V N K R T P R R A A A L I S L T W L I G F L I S I P P M L G W R T P E D R S D P D A C T I S K D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C E S S C H M P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F Q N A F K K I I W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7E2X	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2X (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-	Gi1/β1/γ2	3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-		3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	8W8B	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-	Gi1/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8B (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8JSP	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-	Gi1/β1/γ2	3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSP (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-		3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8FY8	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-	Gi1/β1/γ1	2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FY8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-		2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-	Gi1/β1/γ1	2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-		2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-	Gi1/β1/γ1	2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-		2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-	Gi1/β1/γ1	2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-		2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gi1/β1/γ1	2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8JT6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-	Gi1/β1/γ2	3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8JT6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-		3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8PJK	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-	Gi1/β1/γ1	2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PJK (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-		2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gi1/β1/γ1	2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	9GL2	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gs/β1/γ2	3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9GL2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9DYF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-	Gi1/β1/γ2	2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-		2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-	Go/β1/γ2	2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-		2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Go/β1/γ2	2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851

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