psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W102	4.47	Yes	Yes	1	0	9
2	L:L:?1	R:R:D116	20.41	Yes	No	1	0	8
3	L:L:?1	R:R:V117	8.77	Yes	No	0	0	8
4	L:L:?1	R:R:C187	4.15	Yes	Yes	1	0	9
5	L:L:?1	R:R:F361	15.93	Yes	Yes	1	0	8
6	L:L:?1	R:R:F362	5.57	Yes	Yes	1	0	7
7	L:L:?1	R:R:N386	8.98	Yes	No	0	0	7
8	L:L:?1	R:R:Y390	11.5	Yes	Yes	1	0	8
9	R:R:Q36	R:R:V98	5.73	No	Yes	0	4	6
10	R:R:L43	R:R:W387	13.67	No	Yes	0	7	8
11	R:R:A50	R:R:S86	3.42	No	No	0	8	8
12	R:R:G53	W:W:?1	4.58	No	Yes	0	9	0
13	R:R:D82	R:R:N54	4.04	Yes	No	0	9	9
14	R:R:N54	R:R:P397	6.52	No	No	0	9	9
15	R:R:A79	R:R:V57	3.39	No	No	0	9	9
16	R:R:A401	R:R:V57	3.39	No	No	0	8	9
17	R:R:V57	R:R:Y402	3.79	No	Yes	0	9	6
18	R:R:A60	R:R:F411	4.16	No	No	0	8	8
19	R:R:F407	R:R:I61	5.02	Yes	No	0	8	8
20	R:R:I414	R:R:L63	4.28	No	No	0	7	6
21	R:R:A410	R:R:E64	4.53	No	No	0	8	7
22	R:R:E64	R:R:K413	8.1	No	No	0	7	6
23	R:R:E64	R:R:I414	6.83	No	No	0	7	7
24	R:R:Q68	R:R:R65	9.35	No	No	0	8	7
25	R:R:L67	R:R:N72	4.12	Yes	No	4	8	9
26	R:R:F407	R:R:L67	8.53	Yes	Yes	4	8	8
27	R:R:Q68	R:R:Y73	4.51	No	No	0	8	6
28	R:R:A71	R:R:N69	4.69	No	No	0	8	8
29	R:R:N69	R:R:N72	8.17	No	No	0	8	9
30	R:R:R148	R:R:V70	7.85	Yes	No	0	8	7
31	R:R:P150	R:R:V70	3.53	No	No	0	5	7
32	R:R:F407	R:R:N72	10.87	Yes	No	4	8	9
33	R:R:P150	R:R:Y73	4.17	No	No	0	5	6
34	R:R:D133	R:R:L74	4.07	No	No	0	9	8
35	R:R:H126	R:R:S77	6.97	Yes	No	0	8	9
36	R:R:I157	R:R:S77	10.84	No	No	0	8	9
37	R:R:D82	R:R:L78	5.43	Yes	No	3	9	9
38	R:R:H126	R:R:L78	6.43	Yes	No	0	8	9
39	R:R:L78	R:R:N396	4.12	No	Yes	3	9	9
40	R:R:S122	R:R:T81	6.4	No	No	5	8	9
41	R:R:H126	R:R:T81	5.48	Yes	No	0	8	9
42	R:R:T81	R:R:W161	8.49	No	Yes	5	9	9
43	R:R:D82	R:R:S123	5.89	Yes	No	0	9	9
44	R:R:D82	R:R:S393	5.89	Yes	No	0	9	9
45	R:R:D82	R:R:N396	6.73	Yes	Yes	3	9	9
46	R:R:M84	R:R:W161	3.49	No	Yes	0	7	9
47	R:R:C119	R:R:V85	3.42	No	No	0	7	8
48	R:R:D116	R:R:V89	5.84	No	No	0	8	8
49	R:R:L90	R:R:Y390	5.86	No	Yes	0	8	8
50	R:R:F112	R:R:M92	7.46	No	No	0	6	6
51	R:R:L95	R:R:L99	4.15	No	No	0	6	5
52	R:R:W102	R:R:Y96	8.68	Yes	No	0	9	6
53	R:R:A383	R:R:Q97	4.55	No	No	0	6	7
54	R:R:Q97	R:R:W387	4.38	No	Yes	0	7	8
55	R:R:D185	R:R:K101	5.53	No	No	0	4	5
56	R:R:L104	R:R:W102	11.39	No	Yes	0	7	9
57	R:R:C109	R:R:W102	3.92	No	Yes	1	9	9
58	R:R:C187	R:R:W102	9.14	Yes	Yes	1	9	9
59	R:R:L104	R:R:T108	7.37	No	No	0	7	6
60	R:R:C109	R:R:C187	7.28	No	Yes	1	9	9
61	R:R:D110	R:R:M172	8.32	No	No	0	7	6
62	R:R:D110	R:R:R181	10.72	No	No	0	7	4
63	R:R:D116	R:R:Y390	8.05	No	Yes	1	8	8
64	R:R:L118	R:R:W161	6.83	No	Yes	0	6	9
65	R:R:F165	R:R:L118	10.96	No	No	0	5	6
66	R:R:C120	R:R:W358	5.22	No	Yes	0	7	8
67	R:R:G164	R:R:T121	3.64	No	No	0	8	8
68	R:R:I167	R:R:T121	6.08	No	No	0	8	8
69	R:R:S122	R:R:W161	18.53	No	Yes	5	8	9
70	R:R:I124	R:R:P207	3.39	No	No	0	8	9
71	R:R:F354	R:R:I124	3.77	Yes	No	0	9	8
72	R:R:I124	R:R:W358	9.4	No	Yes	0	8	8
73	R:R:I163	R:R:W125	15.27	No	No	0	5	7
74	R:R:P207	R:R:W125	10.81	No	No	0	9	7
75	R:R:H126	R:R:T160	12.32	Yes	No	0	8	8
76	R:R:L127	R:R:N396	6.87	No	Yes	0	8	9
77	R:R:L127	R:R:Y400	4.69	No	Yes	0	8	9
78	R:R:C128	R:R:M211	4.86	No	Yes	0	7	9
79	R:R:I130	R:R:R134	5.01	No	Yes	2	9	9
80	R:R:I130	R:R:Y400	6.04	No	Yes	2	9	9
81	R:R:A131	R:R:Y215	6.67	No	Yes	0	9	9
82	R:R:L132	R:R:W136	14.81	No	No	0	6	5
83	R:R:L132	R:R:L214	4.15	No	No	0	6	7
84	R:R:D133	R:R:R148	7.15	No	Yes	0	9	8
85	R:R:R134	R:R:Y215	5.14	Yes	Yes	0	9	9
86	R:R:R134	R:R:Y400	4.12	Yes	Yes	2	9	9
87	R:R:R134	W:W:?1	4.07	Yes	Yes	2	9	0
88	R:R:T139	R:R:Y135	13.73	No	Yes	0	8	9
89	R:R:L214	R:R:Y135	5.86	No	Yes	0	7	9
90	R:R:R217	R:R:Y135	11.32	No	Yes	0	7	9
91	R:R:I218	R:R:Y135	3.63	No	Yes	0	9	9
92	R:R:R152	R:R:W136	5	No	No	0	7	5
93	R:R:D140	R:R:D143	6.65	No	No	0	7	6
94	R:R:I142	R:R:N146	4.25	No	No	0	6	5
95	R:R:D143	R:R:K147	4.15	No	No	0	6	5
96	R:R:D143	R:R:R152	10.72	No	No	0	6	7
97	R:R:R148	R:R:Y144	8.23	Yes	No	0	8	8
98	R:R:N146	R:R:V145	4.43	No	No	0	5	6
99	R:R:K147	R:R:N146	5.6	No	No	0	5	5
100	R:R:R148	R:R:R152	7.46	Yes	No	0	8	7
101	R:R:P150	R:R:T149	3.5	No	No	0	5	8
102	R:R:T160	R:R:W161	4.85	No	Yes	0	8	9
103	R:R:I167	R:R:Y198	3.63	No	No	0	8	5
104	R:R:I169	R:R:P170	5.08	No	Yes	0	6	8
105	R:R:P170	R:R:P171	5.84	Yes	No	0	8	7
106	R:R:P170	R:R:W175	8.11	Yes	No	0	8	6
107	R:R:P170	R:R:Y198	5.56	Yes	No	0	8	5
108	R:R:P171	R:R:Y195	16.69	No	Yes	0	7	8
109	R:R:W175	R:R:Y195	4.82	No	Yes	0	6	8
110	R:R:D180	R:R:R176	17.87	No	No	0	4	6
111	R:R:R176	R:R:R181	9.6	No	No	0	6	4
112	R:R:R176	R:R:S190	6.59	No	No	0	6	6
113	R:R:D180	R:R:T177	5.78	No	No	0	4	5
114	R:R:D192	R:R:T177	4.34	No	No	0	6	5
115	R:R:D183	R:R:P184	6.44	No	No	6	1	1
116	R:R:D183	R:R:D185	6.65	No	No	6	1	4
117	R:R:A186	R:R:D183	4.63	No	No	0	4	1
118	R:R:D185	R:R:P184	4.83	No	No	6	4	1
119	R:R:I189	R:R:Y195	3.63	No	Yes	0	6	8
120	R:R:D192	R:R:Y195	3.45	No	Yes	0	6	8
121	R:R:F370	R:R:H193	14.71	No	No	0	5	4
122	R:R:E372	R:R:H193	4.92	No	No	0	3	4
123	R:R:S199	R:R:Y195	7.63	No	Yes	0	8	8
124	R:R:P369	R:R:T196	10.49	No	No	0	7	7
125	R:R:F201	R:R:I197	3.77	No	No	0	5	7
126	R:R:F370	R:R:I197	5.02	No	No	0	5	7
127	R:R:F201	R:R:T200	3.89	No	No	0	5	7
128	R:R:L366	R:R:T200	7.37	No	No	0	7	7
129	R:R:F201	R:R:Y205	8.25	No	No	0	5	7
130	R:R:F204	R:R:Y205	6.19	Yes	No	0	8	7
131	R:R:F204	R:R:F354	5.36	Yes	Yes	0	8	9
132	R:R:F204	R:R:L359	6.09	Yes	Yes	0	8	7
133	R:R:F204	R:R:F362	18.22	Yes	Yes	0	8	7
134	R:R:L366	R:R:Y205	4.69	No	No	0	7	7
135	R:R:I206	R:R:P207	3.39	No	No	0	6	9
136	R:R:F354	R:R:L208	3.65	Yes	No	0	9	7
137	R:R:L210	R:R:L214	4.15	No	No	0	7	7
138	R:R:M211	R:R:Y215	3.59	Yes	Yes	0	9	9
139	R:R:M211	R:R:M351	4.33	Yes	No	0	9	8
140	R:R:F354	R:R:M211	3.73	Yes	Yes	0	9	9
141	R:R:R217	R:R:V213	5.23	No	No	0	7	5
142	R:R:I218	R:R:Y215	3.63	No	Yes	0	9	9
143	R:R:L347	R:R:Y215	4.69	No	Yes	0	8	9
144	R:R:F219	R:R:R223	11.76	Yes	No	0	6	7
145	R:R:F219	R:R:T343	5.19	Yes	No	0	6	8
146	R:R:F219	R:R:L347	3.65	Yes	No	0	6	8
147	R:R:R223	R:R:R227	5.33	No	No	7	7	6
148	R:R:E340	R:R:R223	15.12	Yes	No	7	8	7
149	R:R:F224	R:R:K228	3.72	No	No	0	6	5
150	R:R:I226	R:R:R339	3.76	No	No	0	6	7
151	R:R:E340	R:R:I226	6.83	Yes	No	0	8	6
152	R:R:E340	R:R:R227	10.47	Yes	No	7	8	6
153	R:R:E326	R:R:R327	8.14	No	No	0	3	3
154	R:R:E326	R:R:E330	6.34	No	No	0	3	4
155	R:R:K332	R:R:N328	8.39	No	No	0	6	3
156	R:R:E330	R:R:R333	3.49	No	No	0	4	4
157	R:R:M335	R:R:R339	8.69	No	No	0	4	7
158	R:R:I349	R:R:K345	5.82	No	No	0	7	7
159	R:R:K345	W:W:?1	7.55	No	Yes	0	7	0
160	R:R:T346	W:W:?1	5.92	No	Yes	0	8	0
161	R:R:I399	R:R:T353	4.56	No	No	0	8	7
162	R:R:I355	R:R:L359	4.28	No	Yes	0	7	7
163	R:R:C357	R:R:N392	11.02	No	No	0	8	9
164	R:R:F361	R:R:W358	5.01	Yes	Yes	1	8	8
165	R:R:F362	R:R:W358	5.01	Yes	Yes	1	7	8
166	R:R:G389	R:R:W358	5.63	No	Yes	0	8	8
167	R:R:N392	R:R:W358	9.04	No	Yes	0	9	8
168	R:R:I363	R:R:L359	5.71	No	Yes	0	7	7
169	R:R:F361	R:R:F362	11.79	Yes	Yes	1	8	7
170	R:R:A365	R:R:F361	4.16	No	Yes	0	8	8
171	R:R:L368	R:R:V364	4.47	No	No	0	4	6
172	R:R:I385	R:R:V364	4.61	No	No	0	6	6
173	R:R:L368	R:R:M377	5.65	No	No	0	4	4
174	R:R:M377	R:R:P378	6.71	No	No	0	4	7
175	R:R:L381	R:R:M377	4.24	No	No	0	6	4
176	R:R:I384	R:R:L380	7.14	No	No	0	4	3
177	R:R:G382	R:R:I385	3.53	No	No	0	4	6
178	R:R:W387	R:R:Y390	9.65	Yes	Yes	0	8	8
179	R:R:N392	R:R:N396	10.9	No	Yes	0	9	9
180	R:R:V398	R:R:Y402	3.79	No	Yes	2	6	6
181	R:R:V398	W:W:?1	4.99	No	Yes	2	6	0
182	R:R:I399	R:R:Y400	3.63	No	Yes	0	8	9
183	R:R:F411	R:R:Y402	6.19	No	Yes	0	8	6
184	R:R:Y402	W:W:?1	10.99	Yes	Yes	2	6	0
185	R:R:F403	W:W:?1	41.58	No	Yes	0	8	0
186	R:R:F407	R:R:N404	13.29	Yes	No	0	8	9
187	R:R:N404	W:W:?1	5.52	No	Yes	0	9	0
188	R:R:K412	R:R:N409	4.2	No	No	0	6	6
189	R:R:I414	R:R:I415	4.42	No	No	0	7	7
190	R:R:A203	R:R:T121	3.36	No	No	0	8	8
191	R:R:D192	R:R:G194	3.35	No	No	0	6	5
192	R:R:L359	R:R:P360	3.28	Yes	No	0	7	9
193	R:R:C109	R:R:I113	3.27	No	No	1	9	7
194	R:R:C187	R:R:I113	3.27	Yes	No	1	9	7
195	R:R:S40	R:R:V98	3.23	No	Yes	0	5	6
196	R:R:S393	R:R:V85	3.23	No	No	0	9	8
197	R:R:S168	R:R:V117	3.23	No	No	0	8	8
198	R:R:A114	R:R:M172	3.22	No	No	0	7	6
199	R:R:D140	R:R:P141	3.22	No	No	0	7	8
200	R:R:V58	R:R:V80	3.21	No	No	0	7	7
201	R:R:C375	R:R:L368	3.17	No	No	0	4	4
202	R:R:A94	R:R:L43	3.15	No	No	0	7	7
203	R:R:A50	R:R:L394	3.15	No	No	0	8	7
204	R:R:A410	R:R:L67	3.15	No	Yes	0	8	8
205	L:L:?1	R:R:A93	3.09	Yes	No	0	0	7
206	R:R:I138	R:R:T139	3.04	No	No	0	9	8
207	R:R:L90	R:R:S86	3	No	No	0	8	8
208	R:R:L83	R:R:V51	2.98	Yes	No	0	8	7
209	R:R:L83	R:R:V87	2.98	Yes	No	0	8	6
210	R:R:L395	R:R:T353	2.95	No	No	0	6	7
211	R:R:I189	R:R:K191	2.91	No	No	0	6	5
212	R:R:I47	R:R:L90	2.85	No	No	0	7	8
213	R:R:L212	R:R:M351	2.83	No	No	0	6	8
214	R:R:I385	R:R:N386	2.83	No	No	0	6	7
215	R:R:G174	R:R:W175	2.81	No	No	0	5	6
216	R:R:C56	R:R:F411	2.79	No	No	0	8	8
217	R:R:L156	R:R:L74	2.77	No	No	0	6	8
218	R:R:L115	R:R:L88	2.77	No	No	0	5	6
219	R:R:L162	R:R:L166	2.77	No	No	0	5	5
220	R:R:A203	R:R:F362	2.77	No	Yes	0	8	7
221	R:R:L83	R:R:N54	2.75	Yes	No	0	8	9
222	R:R:K405	R:R:Q408	2.71	No	No	0	6	9
223	R:R:F219	R:R:V344	2.62	Yes	No	0	6	8
224	R:R:F112	R:R:T108	2.59	No	No	0	6	6
225	R:R:K228	R:R:R225	2.48	No	No	0	5	7
226	R:R:F48	R:R:L52	2.44	No	No	0	4	4
227	R:R:I350	R:R:Y215	2.42	No	Yes	0	8	9
228	R:R:L46	R:R:W387	2.28	No	Yes	0	7	8
229	R:R:R217	R:R:R220	2.13	No	No	0	7	5
230	R:R:A79	R:R:G76	1.95	No	No	0	9	6
231	R:R:C371	R:R:C375	1.82	No	No	0	5	4
232	R:R:G44	R:R:I47	1.76	No	No	0	4	7
233	R:R:G202	R:R:I167	1.76	No	No	0	5	8
234	R:R:P178	R:R:T177	1.75	No	No	0	5	5
235	R:R:C357	R:R:S391	1.72	No	No	0	8	5
236	R:R:C371	R:R:S374	1.72	No	No	0	5	5
237	R:R:G53	R:R:L52	1.71	No	No	0	9	4
238	R:R:A79	R:R:V58	1.7	No	No	0	9	7
239	R:R:A153	R:R:V70	1.7	No	No	0	7	7
240	R:R:C49	R:R:T45	1.69	No	No	0	5	4
241	R:R:I47	R:R:P91	1.69	No	No	0	7	9
242	R:R:A129	R:R:T160	1.68	No	No	0	8	8
243	R:R:A221	R:R:T139	1.68	No	No	0	6	8
244	R:R:A222	R:R:T343	1.68	No	No	0	8	8
245	R:R:K191	R:R:P369	1.67	No	No	0	5	7
246	R:R:A401	R:R:I75	1.62	No	No	0	8	8
247	R:R:T39	R:R:V98	1.59	No	Yes	0	5	6
248	R:R:C49	R:R:L394	1.59	No	No	0	5	7
249	R:R:A55	R:R:L83	1.58	No	Yes	0	5	8
250	R:R:E179	R:R:P178	1.57	No	No	0	3	5
251	R:R:I363	R:R:V367	1.54	No	No	0	7	6
252	R:R:F219	R:R:G216	1.51	Yes	No	0	6	3
253	R:R:A336	R:R:E340	1.51	No	Yes	0	5	8
254	R:R:K101	R:R:T103	1.5	No	No	0	5	5
255	R:R:L159	R:R:S158	1.5	No	No	0	3	5
256	R:R:K342	R:R:T346	1.5	No	No	0	8	8
257	R:R:L388	R:R:S391	1.5	No	No	0	8	5
258	R:R:L41	R:R:V37	1.49	No	No	0	4	5
259	R:R:L88	R:R:V89	1.49	No	No	0	6	8
260	R:R:L99	R:R:V98	1.49	No	Yes	0	5	6
261	R:R:L99	R:R:T103	1.47	No	No	0	5	5
262	R:R:D180	R:R:T188	1.45	No	No	0	4	5
263	R:R:I38	R:R:L42	1.43	No	No	0	3	5
264	R:R:L95	R:R:M92	1.41	No	No	0	6	6
265	R:R:A137	R:R:R148	1.38	No	Yes	0	8	8
266	R:R:L159	R:R:L162	1.38	No	No	0	3	5
267	R:R:L356	R:R:L388	1.38	No	No	0	5	8
268	R:R:D406	R:R:L67	1.36	No	Yes	0	7	8
269	R:R:N325	R:R:N328	1.36	No	No	0	5	3
270	R:R:K412	R:R:Q408	1.36	No	No	0	6	9
271	R:R:D406	R:R:N409	1.35	No	No	0	7	6
272	R:R:R151	R:R:T149	1.29	No	No	0	6	8
273	R:R:L337	R:R:R333	1.21	No	No	0	5	4
274	R:R:L166	R:R:Y198	1.17	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.20778	9	1	0
2	R:R:L67	4.29	4	4	8
3	R:R:D82	5.596	5	3	9
4	R:R:L83	2.5725	4	0	8
5	R:R:V98	3.01	4	0	6
6	R:R:W102	7.52	5	1	9
7	R:R:H126	7.8	4	0	8
8	R:R:R134	4.585	4	2	9
9	R:R:Y135	8.635	4	0	9
10	R:R:R148	6.414	5	0	8
11	R:R:W161	8.438	5	5	9
12	R:R:P170	6.1475	4	0	8
13	R:R:C187	5.96	4	1	9
14	R:R:Y195	7.244	5	0	8
15	R:R:F204	8.965	4	0	8
16	R:R:M211	4.1275	4	0	9
17	R:R:Y215	4.35667	6	0	9
18	R:R:F219	4.946	5	0	6
19	R:R:E340	8.4825	4	7	8
20	R:R:F354	4.1275	4	0	9
21	R:R:W358	6.55167	6	1	8
22	R:R:L359	4.84	4	0	7
23	R:R:F361	9.2225	4	1	8
24	R:R:F362	8.672	5	1	7
25	R:R:W387	7.495	4	0	8
26	R:R:Y390	8.765	4	1	8
27	R:R:N396	7.155	4	3	9
28	R:R:Y400	4.62	4	2	9
29	R:R:Y402	6.19	4	2	6
30	R:R:F407	9.4275	4	4	8
31	W:W:?1	10.65	8	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W102	41.0851	4.47	Yes	Yes	1	0	9
2	R:R:L104	R:R:W102	35.346	11.39	No	Yes	0	7	9
3	R:R:L104	R:R:T108	33.2458	7.37	No	No	0	7	6
4	R:R:F112	R:R:T108	31.131	2.59	No	No	0	6	6
5	R:R:F112	R:R:M92	29.0017	7.46	No	No	0	6	6
6	R:R:L95	R:R:M92	26.8577	1.41	No	No	0	6	6
7	R:R:L95	R:R:L99	24.6992	4.15	No	No	0	6	5
8	L:L:?1	R:R:Y390	34.6387	11.5	Yes	Yes	1	0	8
9	R:R:W387	R:R:Y390	13.5565	9.65	Yes	Yes	0	8	8
10	R:R:L90	R:R:Y390	20.2217	5.86	No	Yes	0	8	8
11	R:R:L90	R:R:S86	11.4417	3	No	No	0	8	8
12	L:L:?1	R:R:F361	20.3019	15.93	Yes	Yes	1	0	8
13	R:R:F361	R:R:W358	22.1979	5.01	Yes	Yes	1	8	8
14	R:R:N392	R:R:W358	59.0389	9.04	No	Yes	0	9	8
15	R:R:N392	R:R:N396	54.4811	10.9	No	Yes	0	9	9
16	R:R:D82	R:R:N396	24.4585	6.73	Yes	Yes	3	9	9
17	L:L:?1	R:R:F362	88.1353	5.57	Yes	Yes	1	0	7
18	R:R:F362	R:R:W358	42.0842	5.01	Yes	Yes	1	7	8
19	R:R:D82	R:R:N54	14.2565	4.04	Yes	No	0	9	9
20	R:R:F204	R:R:F362	95.9892	18.22	Yes	Yes	0	8	7
21	R:R:F204	R:R:F354	91.1325	5.36	Yes	Yes	0	8	9
22	R:R:F354	R:R:M211	100	3.73	Yes	Yes	0	9	9
23	R:R:M211	R:R:Y215	98.5707	3.59	Yes	Yes	0	9	9
24	R:R:R134	R:R:Y215	73.1787	5.14	Yes	Yes	0	9	9
25	R:R:R134	W:W:?1	67.7168	4.07	Yes	Yes	2	9	0
26	R:R:Y402	W:W:?1	21.3301	10.99	Yes	Yes	2	6	0
27	R:R:V57	R:R:Y402	13.8263	3.79	No	Yes	0	9	6
28	R:R:N404	W:W:?1	34.1209	5.52	No	Yes	0	9	0
29	R:R:F407	R:R:N404	32.3489	13.29	Yes	No	0	8	9
30	R:R:F407	R:R:L67	23.0074	8.53	Yes	Yes	4	8	8
31	R:R:A410	R:R:L67	11.8938	3.15	No	Yes	0	8	8
32	R:R:I218	R:R:Y215	60.388	3.63	No	Yes	0	9	9
33	R:R:I218	R:R:Y135	58.8493	3.63	No	Yes	0	9	9
34	R:R:L214	R:R:Y135	47.6701	5.86	No	Yes	0	7	9
35	R:R:L132	R:R:L214	44.3448	4.15	No	No	0	6	7
36	R:R:L132	R:R:W136	42.6602	14.81	No	No	0	6	5
37	R:R:R152	R:R:W136	40.9538	5	No	No	0	7	5
38	R:R:R148	R:R:R152	26.9452	7.46	Yes	No	0	8	7
39	R:R:R148	R:R:V70	15.7442	7.85	Yes	No	0	8	7
40	R:R:P150	R:R:V70	11.8938	3.53	No	No	0	5	7
41	R:R:L78	R:R:N396	35.5794	4.12	No	Yes	3	9	9
42	R:R:H126	R:R:L78	34.6678	6.43	Yes	No	0	8	9
43	R:R:H126	R:R:T81	14.0086	5.48	Yes	No	0	8	9
44	R:R:H126	R:R:T160	14.0086	12.32	Yes	No	0	8	8
45	R:R:L99	R:R:T103	13.6877	1.47	No	No	0	5	5
46	R:R:K101	R:R:T103	11.4417	1.5	No	No	0	5	5
47	R:R:A203	R:R:F362	84.4673	2.77	No	Yes	0	8	7
48	R:R:A203	R:R:T121	83.2495	3.36	No	No	0	8	8
49	R:R:I167	R:R:T121	80.7628	6.08	No	No	0	8	8
50	R:R:I167	R:R:Y198	78.3126	3.63	No	No	0	8	5
51	R:R:P170	R:R:Y198	71.713	5.56	Yes	No	0	8	5
52	R:R:P170	R:R:P171	33.6104	5.84	Yes	No	0	8	7
53	R:R:P171	R:R:Y195	32.0645	16.69	No	Yes	0	7	8
54	R:R:D192	R:R:Y195	44.6438	3.45	No	Yes	0	6	8
55	R:R:D192	R:R:T177	37.9348	4.34	No	No	0	6	5
56	R:R:D180	R:R:T177	27.762	5.78	No	No	0	4	5
57	R:R:D180	R:R:R176	20.9072	17.87	No	No	0	4	6
58	R:R:R176	R:R:R181	13.994	9.6	No	No	0	6	4
59	R:R:D110	R:R:R181	10.5156	10.72	No	No	0	7	4
60	R:R:P170	R:R:W175	35.3825	8.11	Yes	No	0	8	6
61	R:R:W175	R:R:Y195	32.2905	4.82	No	Yes	0	6	8
62	R:R:I124	R:R:W358	14.468	9.4	No	Yes	0	8	8
63	R:R:L127	R:R:N396	33.2458	6.87	No	Yes	0	8	9
64	R:R:L127	R:R:Y400	32.3197	4.69	No	Yes	0	8	9
65	R:R:D143	R:R:R152	13.819	10.72	No	No	0	6	7
66	R:R:I189	R:R:Y195	13.9065	3.63	No	Yes	0	6	8
67	R:R:F204	R:R:Y205	17.1443	6.19	Yes	No	0	8	7
68	R:R:F201	R:R:Y205	11.5365	8.25	No	No	0	5	7
69	R:R:I189	R:R:K191	10.5156	2.91	No	No	0	6	5
70	R:R:L347	R:R:Y215	24.9398	4.69	No	Yes	0	8	9
71	R:R:F219	R:R:L347	23.0949	3.65	Yes	No	0	6	8
72	R:R:F219	R:R:R223	13.6513	11.76	Yes	No	0	6	7
73	R:R:C357	R:R:N392	10.9021	11.02	No	No	0	8	9
74	L:L:?1	R:R:N386	24.5898	8.98	Yes	No	0	0	7
75	R:R:I385	R:R:N386	22.5261	2.83	No	No	0	6	7
76	R:R:I385	R:R:V364	18.1361	4.61	No	No	0	6	6
77	R:R:L368	R:R:V364	15.9192	4.47	No	No	0	4	6
78	R:R:F354	R:R:I124	11.0042	3.77	Yes	No	0	9	8
79	R:R:R134	R:R:Y400	27.9807	4.12	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:W102	4.47	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:D116	20.41	1	Yes	No	0	8	0	1
L:L:?1	R:R:V117	8.77	1	Yes	No	0	8	0	1
L:L:?1	R:R:C187	4.15	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F361	15.93	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F362	5.57	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N386	8.98	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y390	11.5	1	Yes	Yes	0	8	0	1
R:R:D116	R:R:V89	5.84	1	No	No	8	8	1	2
R:R:L90	R:R:Y390	5.86	0	No	Yes	8	8	2	1
R:R:W102	R:R:Y96	8.68	1	Yes	No	9	6	1	2
R:R:L104	R:R:W102	11.39	0	No	Yes	7	9	2	1
R:R:C109	R:R:W102	3.92	1	No	Yes	9	9	2	1
R:R:C187	R:R:W102	9.14	1	Yes	Yes	9	9	1	1
R:R:C109	R:R:C187	7.28	1	No	Yes	9	9	2	1
R:R:D116	R:R:Y390	8.05	1	No	Yes	8	8	1	1
R:R:F204	R:R:F362	18.22	0	Yes	Yes	8	7	2	1
R:R:F361	R:R:W358	5.01	1	Yes	Yes	8	8	1	2
R:R:F362	R:R:W358	5.01	1	Yes	Yes	7	8	1	2
R:R:F361	R:R:F362	11.79	1	Yes	Yes	8	7	1	1
R:R:A365	R:R:F361	4.16	0	No	Yes	8	8	2	1
R:R:W387	R:R:Y390	9.65	0	Yes	Yes	8	8	2	1
R:R:C109	R:R:I113	3.27	1	No	No	9	7	2	2
R:R:C187	R:R:I113	3.27	1	Yes	No	9	7	1	2
R:R:S168	R:R:V117	3.23	0	No	No	8	8	2	1
L:L:?1	R:R:A93	3.09	1	Yes	No	0	7	0	1
R:R:I385	R:R:N386	2.83	0	No	No	6	7	2	1
R:R:A203	R:R:F362	2.77	0	No	Yes	8	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:G53	W:W:?1	4.58	0	No	Yes	9	0	1	0
R:R:V57	R:R:Y402	3.79	0	No	Yes	9	6	2	1
R:R:I130	R:R:R134	5.01	2	No	Yes	9	9	2	1
R:R:I130	R:R:Y400	6.04	2	No	Yes	9	9	2	2
R:R:R134	R:R:Y215	5.14	2	Yes	Yes	9	9	1	2
R:R:R134	R:R:Y400	4.12	2	Yes	Yes	9	9	1	2
R:R:R134	W:W:?1	4.07	2	Yes	Yes	9	0	1	0
R:R:I349	R:R:K345	5.82	0	No	No	7	7	2	1
R:R:K345	W:W:?1	7.55	0	No	Yes	7	0	1	0
R:R:T346	W:W:?1	5.92	0	No	Yes	8	0	1	0
R:R:V398	R:R:Y402	3.79	2	No	Yes	6	6	1	1
R:R:V398	W:W:?1	4.99	2	No	Yes	6	0	1	0
R:R:F411	R:R:Y402	6.19	0	No	Yes	8	6	2	1
R:R:Y402	W:W:?1	10.99	2	Yes	Yes	6	0	1	0
R:R:F403	W:W:?1	41.58	0	No	Yes	8	0	1	0
R:R:F407	R:R:N404	13.29	4	Yes	No	8	9	2	1
R:R:N404	W:W:?1	5.52	0	No	Yes	9	0	1	0
R:R:G53	R:R:L52	1.71	0	No	No	9	4	1	2
R:R:K342	R:R:T346	1.5	0	No	No	8	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9DYE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.39
Number of Linked Nodes	263
Number of Links	274
Number of Hubs	31
Number of Links mediated by Hubs	123
Number of Communities	7
Number of Nodes involved in Communities	31
Number of Links involved in Communities	37

Path Summary
Number Of Nodes in MetaPath	80
Number Of Links MetaPath	79
Number of Shortest Paths	39135
Length Of Smallest Path	3
Average Path Length	13.1925
Length of Longest Path	32
Minimum Path Strength	1.355
Average Path Strength	6.20807
Maximum Path Strength	26.285
Minimum Path Correlation	0.7
Average Path Correlation	0.937342
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	55.4886
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.4995
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cation binding • binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • protein binding • signaling receptor binding • receptor-receptor interaction • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • behavior • multicellular organismal process • exploration behavior • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • adult behavior • regulation of tube diameter • system process • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • cell-cell signaling • gamma-aminobutyric acid signaling pathway • regulation of behavior • serotonin metabolic process • indole-containing compound metabolic process • cellular response to nitrogen compound • response to dopamine • serotonin receptor signaling pathway • cellular response to dopamine • response to monoamine • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to catecholamine • cellular response to monoamine stimulus • response to chemical • cellular response to catecholamine stimulus • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • monoatomic ion transport • serotonin secretion • regulation of monoatomic ion transport • regulation of serotonin secretion • serotonin transport • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell periphery • cellular anatomical structure • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • mu-type opioid receptor binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • cation binding • metal ion binding • heart process • regulation of heart contraction • heart contraction • locomotory behavior • membrane docking • vesicle-mediated transport • organelle localization by membrane tethering • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • negative regulation of protein transport • establishment of protein localization • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • negative regulation of cellular process • negative regulation of protein localization • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • insulin secretion • modulation of chemical synaptic transmission • regulation of trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • GABA-ergic synapse • glutamatergic synapse • cell body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	YLX
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	YLX
Name	Buspirone
Synonyms	Buspironum
Identifier
Formula	C21 H31 N5 O2
Molecular Weight	385.503
SMILES
PubChem	2477
Formal Charge	0
Total Atoms	59
Total Chiral Atoms	0
Total Bonds	62
Total Aromatic Bonds	6


Code	J40
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	J40
Name	[(2R)-1-[oxidanyl-[(2R,3R,5S,6R)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5E,8E)-hexadeca-5,8,11,14-tetraenoate
Synonyms
Identifier
Formula	C39 H68 O16 P2
Molecular Weight	854.895
SMILES
PubChem
Formal Charge	0
Total Atoms	125
Total Chiral Atoms	5
Total Bonds	125
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08908
Sequence	>9DYE_nogp_Chain_R Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E R S L Q N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N K W T L G Q V T C D L F I A L D V L C C T S S I H L C A I A L D R Y W A I T D P I D Y V N K R T P R R A A A L I S L T W L I G F L I S I P P M L G W R T P E D R S D P D A C T I S K D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C E S S C H M P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F Q N A F K K I I W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7E2X	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	PtdIns4P	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2X (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	PtdIns4P		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	PtdIns4P	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	PtdIns4P		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	PtdIns4P	Gi1/β1/γ2	3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	PtdIns4P		3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	8JSP	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-	Gi1/β1/γ2	3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSP (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-		3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8W8B	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-	Gi1/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8B (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8FY8	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P	Gi1/β1/γ1	2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FY8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P		2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	PtdIns4P	Gi1/β1/γ1	2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	PtdIns4P		2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	PtdIns4P	Gi1/β1/γ1	2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	PtdIns4P		2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	PtdIns4P	Gi1/β1/γ1	2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	PtdIns4P		2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gi1/β1/γ1	2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8PJK	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-	Gi1/β1/γ1	2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PJK (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-		2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gi1/β1/γ1	2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8JT6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	PtdIns4P	Gi1/β1/γ2	3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8JT6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	PtdIns4P		3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	9GL2	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gs/β1/γ2	3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9GL2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9DYD	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P	Go/β1/γ2	2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P		2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Go/β1/γ2	2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P	Gi1/β1/γ2	2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P		2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9VJ5	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Gepirone	-	Go/β1/γ2	2.69	2025-11-12	To be published
	9VJ5 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Gepirone	-		2.69	2025-11-12	To be published
	9VJ6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	F-15599	-	Gi3/β1/γ2	2.62	2025-11-12	To be published
	9VJ6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	F-15599	-		2.62	2025-11-12	To be published
	9VJE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Go/β1/γ2	2.47	2025-11-12	To be published
	9VJE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.47	2025-11-12	To be published
	9VJF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gi3/β1/γ2	2.7	2025-11-12	To be published
	9VJF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.7	2025-11-12	To be published
	9VJG	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	8-OH-DPAT	-	chim(NtGi2-Gz)/β1/γ2	2.67	2025-11-12	To be published
	9VJG (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	8-OH-DPAT	-		2.67	2025-11-12	To be published
	9VMY	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	TMU4142	-	Go/β1/γ2	2.86	2025-11-12	To be published
	9VMY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	TMU4142	-		2.86	2025-11-12	To be published
	9VNF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Pindolol	-	Go/β1/γ2	2.74	2025-11-12	To be published
	9VNF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Pindolol	-		2.74	2025-11-12	To be published
	9KVG	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P	Gi1/β1/γ2	2.63	2025-12-03	To be published
	9KVG (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P		2.63	2025-12-03	To be published
	9KVH	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Cinobufotenine	PtdIns4P	Gi1/β1/γ2	2.59	2025-12-03	To be published
	9KVH (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Cinobufotenine	PtdIns4P		2.59	2025-12-03	To be published
	9KVI	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Bufotenin	PtdIns4P	Gi1/β1/γ2	2.54	2025-12-03	To be published
	9KVI (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Bufotenin	PtdIns4P		2.54	2025-12-03	To be published
	9HYI	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	DP81	-	Gi1/β1/γ2	2.3	2026-01-21	To be published
	9HYI (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	DP81	-		2.3	2026-01-21	To be published

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Download 9DYE_nogp.zip

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