| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8FYX | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo Sapiens | Buspirone | - | Gi1/Beta1/Gamma1 | 2.72 | 2024-05-15 | doi.org/10.1038/s41586-024-07403-2 |
|
A 2D representation of the interactions of YLX in 8FYX
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:Y96 | 9.2 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:W102 | 5.21 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | | L:L:?1 | R:R:D116 | 16.86 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:V117 | 8.77 | 1 | Yes | No | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:C120 | 5.19 | 1 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:F361 | 16.72 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:F362 | 7.96 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:N386 | 8.08 | 1 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:Y390 | 10.73 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | R:R:D116 | R:R:V89 | 11.69 | 1 | Yes | No | 8 | 8 | 1 | 2 | | R:R:V89 | R:R:Y390 | 3.79 | 1 | No | Yes | 8 | 8 | 2 | 1 | | R:R:L90 | R:R:W387 | 4.56 | 1 | No | Yes | 8 | 8 | 2 | 2 | | R:R:L90 | R:R:Y390 | 9.38 | 1 | No | Yes | 8 | 8 | 2 | 1 | | R:R:A93 | R:R:Y390 | 5.34 | 0 | No | Yes | 7 | 8 | 2 | 1 | | R:R:W102 | R:R:Y96 | 5.79 | 1 | Yes | No | 9 | 6 | 1 | 1 | | R:R:L104 | R:R:W102 | 12.53 | 0 | No | Yes | 7 | 9 | 2 | 1 | | R:R:C109 | R:R:W102 | 9.14 | 1 | No | Yes | 9 | 9 | 2 | 1 | | R:R:F112 | R:R:W102 | 5.01 | 0 | No | Yes | 6 | 9 | 2 | 1 | | R:R:C187 | R:R:W102 | 16.98 | 1 | No | Yes | 9 | 9 | 2 | 1 | | R:R:C109 | R:R:C187 | 7.28 | 1 | No | No | 9 | 9 | 2 | 2 | | R:R:C120 | R:R:D116 | 4.67 | 1 | No | Yes | 7 | 8 | 1 | 1 | | R:R:D116 | R:R:Y390 | 11.49 | 1 | Yes | Yes | 8 | 8 | 1 | 1 | | R:R:C120 | R:R:W358 | 5.22 | 1 | No | Yes | 7 | 8 | 1 | 2 | | R:R:F362 | R:R:T200 | 5.19 | 1 | Yes | No | 7 | 7 | 1 | 2 | | R:R:F204 | R:R:F362 | 20.36 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:F361 | R:R:W358 | 8.02 | 1 | Yes | Yes | 8 | 8 | 1 | 2 | | R:R:F362 | R:R:W358 | 9.02 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | | R:R:F361 | R:R:F362 | 13.93 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | | R:R:F361 | R:R:N386 | 4.83 | 1 | Yes | No | 8 | 7 | 1 | 1 | | R:R:W387 | R:R:Y390 | 8.68 | 1 | Yes | Yes | 8 | 8 | 2 | 1 | | R:R:S168 | R:R:V117 | 3.23 | 0 | No | No | 8 | 8 | 2 | 1 | | R:R:A365 | R:R:F361 | 2.77 | 0 | No | Yes | 8 | 8 | 2 | 1 | | R:R:A186 | R:R:Y96 | 1.33 | 0 | No | No | 4 | 6 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 9.00 | | Average Number Of Links With An Hub | 5.00 | | Average Interaction Strength | 9.86 | | Average Nodes In Shell | 24.00 | | Average Hubs In Shell | 9.00 | | Average Links In Shell | 33.00 | | Average Links Mediated by Hubs In Shell | 30.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9DYE | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo Sapiens | Buspirone | - | Go/Beta1/Gamma2 | 2.9 | 2025-08-13 | doi.org/10.1126/sciadv.adu9851 |
|
A 2D representation of the interactions of YLX in 9DYE
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:A93 | 3.09 | 2 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:W102 | 4.47 | 2 | Yes | Yes | 0 | 9 | 0 | 1 | | L:L:?1 | R:R:F112 | 2.39 | 2 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:D116 | 20.41 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:V117 | 8.77 | 2 | Yes | No | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:C120 | 3.11 | 2 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:T121 | 1.93 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:C187 | 4.15 | 2 | Yes | Yes | 0 | 9 | 0 | 1 | | L:L:?1 | R:R:I189 | 1.87 | 2 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:A203 | 2.06 | 2 | Yes | No | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:W358 | 2.23 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:F361 | 15.93 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:F362 | 5.57 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:N386 | 8.98 | 2 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:Y390 | 11.5 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | | R:R:D116 | R:R:V89 | 5.84 | 2 | Yes | No | 8 | 8 | 1 | 2 | | R:R:L90 | R:R:Y390 | 5.86 | 0 | Yes | Yes | 8 | 8 | 2 | 1 | | R:R:F112 | R:R:M92 | 7.46 | 0 | No | No | 6 | 6 | 1 | 2 | | R:R:A93 | R:R:W387 | 2.59 | 2 | No | Yes | 7 | 8 | 1 | 2 | | R:R:A93 | R:R:Y390 | 2.67 | 2 | No | Yes | 7 | 8 | 1 | 1 | | R:R:W102 | R:R:Y96 | 8.68 | 2 | Yes | No | 9 | 6 | 1 | 2 | | R:R:L104 | R:R:W102 | 11.39 | 2 | No | Yes | 7 | 9 | 2 | 1 | | R:R:T108 | R:R:W102 | 2.43 | 2 | No | Yes | 6 | 9 | 2 | 1 | | R:R:C109 | R:R:W102 | 3.92 | 2 | No | Yes | 9 | 9 | 2 | 1 | | R:R:C187 | R:R:W102 | 9.14 | 2 | Yes | Yes | 9 | 9 | 1 | 1 | | R:R:L104 | R:R:T108 | 7.37 | 2 | No | No | 7 | 6 | 2 | 2 | | R:R:F112 | R:R:T108 | 2.59 | 0 | No | No | 6 | 6 | 1 | 2 | | R:R:C109 | R:R:I113 | 3.27 | 2 | No | No | 9 | 7 | 2 | 2 | | R:R:C109 | R:R:C187 | 7.28 | 2 | No | Yes | 9 | 9 | 2 | 1 | | R:R:C187 | R:R:I113 | 3.27 | 2 | Yes | No | 9 | 7 | 1 | 2 | | R:R:C120 | R:R:D116 | 3.11 | 2 | No | Yes | 7 | 8 | 1 | 1 | | R:R:D116 | R:R:Y390 | 8.05 | 2 | Yes | Yes | 8 | 8 | 1 | 1 | | R:R:S168 | R:R:V117 | 3.23 | 0 | No | No | 8 | 8 | 2 | 1 | | R:R:C120 | R:R:W358 | 5.22 | 2 | No | Yes | 7 | 8 | 1 | 1 | | R:R:T121 | R:R:W125 | 2.43 | 2 | Yes | Yes | 8 | 7 | 1 | 2 | | R:R:G164 | R:R:T121 | 3.64 | 0 | No | Yes | 8 | 8 | 2 | 1 | | R:R:I167 | R:R:T121 | 6.08 | 0 | No | Yes | 8 | 8 | 2 | 1 | | R:R:A203 | R:R:T121 | 3.36 | 2 | No | Yes | 8 | 8 | 1 | 1 | | R:R:F354 | R:R:I124 | 3.77 | 2 | Yes | No | 9 | 8 | 2 | 2 | | R:R:I124 | R:R:W358 | 9.4 | 2 | No | Yes | 8 | 8 | 2 | 1 | | R:R:I189 | R:R:K191 | 2.91 | 0 | No | No | 6 | 5 | 1 | 2 | | R:R:I189 | R:R:Y195 | 3.63 | 0 | No | Yes | 6 | 8 | 1 | 2 | | R:R:F362 | R:R:T200 | 2.59 | 2 | Yes | Yes | 7 | 7 | 1 | 2 | | R:R:A203 | R:R:F362 | 2.77 | 2 | No | Yes | 8 | 7 | 1 | 1 | | R:R:F204 | R:R:F354 | 5.36 | 2 | Yes | Yes | 8 | 9 | 2 | 2 | | R:R:F204 | R:R:W358 | 3.01 | 2 | Yes | Yes | 8 | 8 | 2 | 1 | | R:R:F204 | R:R:F362 | 18.22 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:F354 | R:R:W358 | 3.01 | 2 | Yes | Yes | 9 | 8 | 2 | 1 | | R:R:F361 | R:R:W358 | 5.01 | 2 | Yes | Yes | 8 | 8 | 1 | 1 | | R:R:F362 | R:R:W358 | 5.01 | 2 | Yes | Yes | 7 | 8 | 1 | 1 | | R:R:G389 | R:R:W358 | 5.63 | 0 | No | Yes | 8 | 8 | 2 | 1 | | R:R:N392 | R:R:W358 | 9.04 | 0 | No | Yes | 9 | 8 | 2 | 1 | | R:R:F361 | R:R:F362 | 11.79 | 2 | Yes | Yes | 8 | 7 | 1 | 1 | | R:R:A365 | R:R:F361 | 4.16 | 0 | No | Yes | 8 | 8 | 2 | 1 | | R:R:F361 | R:R:N386 | 2.42 | 2 | Yes | No | 8 | 7 | 1 | 1 | | R:R:I385 | R:R:N386 | 2.83 | 0 | No | No | 6 | 7 | 2 | 1 | | R:R:W387 | R:R:Y390 | 9.65 | 2 | Yes | Yes | 8 | 8 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 15.00 | | Average Number Of Links With An Hub | 8.00 | | Average Interaction Strength | 6.43 | | Average Nodes In Shell | 39.00 | | Average Hubs In Shell | 16.00 | | Average Links In Shell | 57.00 | | Average Links Mediated by Hubs In Shell | 50.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9MD1 | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo Sapiens | Buspirone | - | Gz/Beta1/Gamma2 | 3.03 | 2025-08-13 | doi.org/10.1126/sciadv.adu9851 |
|
A 2D representation of the interactions of YLX in 9MD1
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:V89 | 1.95 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:A93 | 5.15 | 1 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:Y96 | 6.9 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:W102 | 5.21 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | | L:L:?1 | R:R:F112 | 3.98 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:D116 | 19.52 | 1 | Yes | No | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:V117 | 6.82 | 1 | Yes | No | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:C120 | 6.23 | 1 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:T121 | 1.93 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:C187 | 4.15 | 1 | Yes | No | 0 | 9 | 0 | 1 | | L:L:?1 | R:R:I189 | 1.87 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:A203 | 2.06 | 1 | Yes | No | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:F361 | 14.33 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:F362 | 7.17 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:N386 | 7.18 | 1 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:Y390 | 8.43 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | R:R:D116 | R:R:V89 | 7.3 | 1 | No | Yes | 8 | 8 | 1 | 1 | | R:R:C119 | R:R:V89 | 1.71 | 0 | No | Yes | 7 | 8 | 2 | 1 | | R:R:V89 | R:R:Y390 | 3.79 | 1 | Yes | Yes | 8 | 8 | 1 | 1 | | R:R:L90 | R:R:W387 | 2.28 | 1 | No | Yes | 8 | 8 | 2 | 2 | | R:R:L90 | R:R:Y390 | 8.21 | 1 | No | Yes | 8 | 8 | 2 | 1 | | R:R:M92 | R:R:W102 | 3.49 | 1 | No | Yes | 6 | 9 | 2 | 1 | | R:R:L104 | R:R:M92 | 4.24 | 1 | Yes | No | 7 | 6 | 2 | 2 | | R:R:F112 | R:R:M92 | 13.68 | 1 | Yes | No | 6 | 6 | 1 | 2 | | R:R:A93 | R:R:W387 | 2.59 | 0 | No | Yes | 7 | 8 | 1 | 2 | | R:R:W102 | R:R:Y96 | 7.72 | 1 | Yes | No | 9 | 6 | 1 | 1 | | R:R:D185 | R:R:Y96 | 9.2 | 0 | No | No | 4 | 6 | 2 | 1 | | R:R:L104 | R:R:W102 | 10.25 | 1 | Yes | Yes | 7 | 9 | 2 | 1 | | R:R:T108 | R:R:W102 | 4.85 | 1 | Yes | Yes | 6 | 9 | 2 | 1 | | R:R:C109 | R:R:W102 | 3.92 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | | R:R:F112 | R:R:W102 | 5.01 | 1 | Yes | Yes | 6 | 9 | 1 | 1 | | R:R:C187 | R:R:W102 | 14.37 | 1 | No | Yes | 9 | 9 | 1 | 1 | | R:R:L104 | R:R:T108 | 5.9 | 1 | Yes | Yes | 7 | 6 | 2 | 2 | | R:R:F112 | R:R:T108 | 2.59 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | | R:R:C109 | R:R:C187 | 5.46 | 1 | Yes | No | 9 | 9 | 2 | 1 | | R:R:D116 | R:R:Y390 | 10.34 | 1 | No | Yes | 8 | 8 | 1 | 1 | | R:R:S168 | R:R:V117 | 3.23 | 0 | No | No | 8 | 8 | 2 | 1 | | R:R:C120 | R:R:W358 | 5.22 | 0 | No | Yes | 7 | 8 | 1 | 2 | | R:R:T121 | R:R:W125 | 2.43 | 1 | Yes | Yes | 8 | 7 | 1 | 2 | | R:R:G164 | R:R:T121 | 3.64 | 0 | No | Yes | 8 | 8 | 2 | 1 | | R:R:A203 | R:R:T121 | 5.03 | 1 | No | Yes | 8 | 8 | 1 | 1 | | R:R:I124 | R:R:W358 | 9.4 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | | R:R:F362 | R:R:I124 | 2.51 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | | R:R:I189 | R:R:Y195 | 7.25 | 0 | No | Yes | 6 | 8 | 1 | 2 | | R:R:F362 | R:R:T200 | 2.59 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | | R:R:A203 | R:R:F362 | 2.77 | 1 | No | Yes | 8 | 7 | 1 | 1 | | R:R:F204 | R:R:W358 | 3.01 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | | R:R:F204 | R:R:F362 | 20.36 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:F361 | R:R:W358 | 7.02 | 1 | Yes | Yes | 8 | 8 | 1 | 2 | | R:R:F362 | R:R:W358 | 6.01 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | | R:R:F361 | R:R:F362 | 9.65 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | | R:R:F361 | R:R:N386 | 2.42 | 1 | Yes | No | 8 | 7 | 1 | 1 | | R:R:W387 | R:R:Y390 | 5.79 | 1 | Yes | Yes | 8 | 8 | 2 | 1 | | R:R:L115 | R:R:V89 | 1.49 | 0 | No | Yes | 5 | 8 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 16.00 | | Average Number Of Links With An Hub | 7.00 | | Average Interaction Strength | 6.43 | | Average Nodes In Shell | 34.00 | | Average Hubs In Shell | 18.00 | | Average Links In Shell | 54.00 | | Average Links Mediated by Hubs In Shell | 52.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
