psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T32	R:R:V33	4.76	No	No	0	4	4
2	R:R:Q36	R:R:T32	5.67	No	No	0	4	4
3	R:R:S34	R:R:V33	3.23	No	No	0	3	4
4	R:R:Q36	R:R:Y35	3.38	No	No	0	4	4
5	R:R:T39	R:R:Y35	6.24	Yes	No	0	5	4
6	R:R:N100	R:R:Y35	9.3	No	No	0	5	4
7	R:R:L41	R:R:V37	2.98	No	No	0	4	5
8	R:R:T39	R:R:V98	3.17	Yes	No	0	5	6
9	R:R:A94	R:R:L43	4.73	No	No	0	7	7
10	R:R:L43	R:R:W387	13.67	No	No	0	7	8
11	R:R:I47	R:R:L90	4.28	No	Yes	0	7	8
12	R:R:A50	R:R:S86	3.42	No	No	0	8	8
13	R:R:A50	R:R:L394	4.73	No	No	0	8	7
14	R:R:L83	R:R:V51	4.47	Yes	No	0	8	7
15	R:R:C56	R:R:L52	3.17	No	No	0	8	4
16	R:R:G53	R:R:Y402	4.35	No	Yes	0	9	6
17	R:R:D82	R:R:N54	6.73	Yes	No	0	9	9
18	R:R:L83	R:R:N54	5.49	Yes	No	0	8	9
19	R:R:N54	R:R:P397	8.15	No	No	0	9	9
20	R:R:A79	R:R:V57	3.39	No	No	0	9	9
21	R:R:A401	R:R:V57	5.09	No	No	0	8	9
22	R:R:V57	R:R:Y402	5.05	No	Yes	0	9	6
23	R:R:V58	R:R:V80	3.21	No	No	0	7	7
24	R:R:A60	R:R:F411	4.16	No	No	0	8	8
25	R:R:F407	R:R:I61	5.02	Yes	No	0	8	8
26	R:R:A410	R:R:E64	7.54	No	No	0	8	7
27	R:R:E64	R:R:K413	12.15	No	No	0	7	6
28	R:R:L67	R:R:S66	3	No	No	0	8	6
29	R:R:F407	R:R:L67	9.74	Yes	No	0	8	8
30	R:R:A410	R:R:L67	4.73	No	No	0	8	8
31	R:R:Q68	R:R:Y73	7.89	No	No	0	8	6
32	R:R:N69	R:R:N72	12.26	No	No	0	8	9
33	R:R:R148	R:R:V70	13.08	No	No	0	8	7
34	R:R:P150	R:R:V70	5.3	No	No	0	5	7
35	R:R:F407	R:R:N72	8.46	Yes	No	0	8	9
36	R:R:P150	R:R:Y73	4.17	No	No	0	5	6
37	R:R:D133	R:R:L74	4.07	No	Yes	0	9	8
38	R:R:A153	R:R:L74	3.15	No	Yes	0	7	8
39	R:R:L156	R:R:L74	4.15	No	Yes	0	6	8
40	R:R:I75	R:R:Y400	3.63	No	Yes	0	8	9
41	R:R:H126	R:R:S77	8.37	Yes	No	1	8	9
42	R:R:I157	R:R:S77	10.84	No	No	1	8	9
43	R:R:D82	R:R:L78	6.79	Yes	Yes	1	9	9
44	R:R:L78	R:R:S123	3	Yes	No	1	9	9
45	R:R:H126	R:R:L78	7.71	Yes	Yes	1	8	9
46	R:R:L78	R:R:N396	6.87	Yes	Yes	1	9	9
47	R:R:L78	R:R:Y400	3.52	Yes	Yes	1	9	9
48	R:R:M84	R:R:V80	3.04	No	No	0	7	7
49	R:R:S122	R:R:T81	7.99	Yes	No	1	8	9
50	R:R:H126	R:R:T81	8.21	Yes	No	1	8	9
51	R:R:T81	R:R:W161	8.49	No	Yes	1	9	9
52	R:R:D82	R:R:S123	5.89	Yes	No	1	9	9
53	R:R:D82	R:R:S393	8.83	Yes	No	0	9	9
54	R:R:D82	R:R:N396	8.08	Yes	Yes	1	9	9
55	R:R:L83	R:R:V87	2.98	Yes	No	0	8	6
56	R:R:C119	R:R:M84	3.24	No	No	0	7	7
57	R:R:M84	R:R:W161	5.82	No	Yes	0	7	9
58	R:R:L90	R:R:V85	2.98	Yes	No	0	8	8
59	R:R:S393	R:R:V85	8.08	No	No	0	9	8
60	R:R:L90	R:R:S86	6.01	Yes	No	0	8	8
61	R:R:L88	R:R:V87	4.47	No	No	0	6	6
62	R:R:L115	R:R:L88	4.15	No	No	0	5	6
63	R:R:F112	R:R:V89	5.24	Yes	No	1	6	8
64	R:R:D116	R:R:V89	8.76	Yes	No	1	8	8
65	R:R:V89	R:R:Y390	3.79	No	Yes	1	8	8
66	R:R:L90	R:R:Y390	7.03	Yes	Yes	0	8	8
67	R:R:M92	R:R:W102	4.65	No	Yes	1	6	9
68	R:R:F112	R:R:M92	9.95	Yes	No	1	6	6
69	R:R:L95	R:R:L99	5.54	No	No	0	6	5
70	R:R:W102	R:R:Y96	7.72	Yes	No	0	9	6
71	L:L:?1	R:R:Y96	17.88	Yes	No	0	0	6
72	R:R:A383	R:R:Q97	4.55	No	No	0	6	7
73	R:R:Q97	R:R:W387	13.14	No	No	0	7	8
74	L:L:?1	R:R:Q97	9.75	Yes	No	0	0	7
75	R:R:L99	R:R:V98	2.98	No	No	0	5	6
76	R:R:K101	R:R:T103	6.01	No	No	0	5	5
77	R:R:D185	R:R:K101	9.68	No	No	0	4	5
78	R:R:L104	R:R:W102	6.83	No	Yes	0	7	9
79	R:R:C109	R:R:W102	5.22	No	Yes	1	9	9
80	R:R:F112	R:R:W102	7.02	Yes	Yes	1	6	9
81	R:R:C187	R:R:W102	10.45	No	Yes	1	9	9
82	R:R:L104	R:R:T108	7.37	No	No	0	7	6
83	R:R:C109	R:R:I113	3.27	No	No	1	9	7
84	R:R:C109	R:R:C187	7.28	No	No	1	9	9
85	R:R:L111	R:R:L115	4.15	No	No	0	5	5
86	R:R:C187	R:R:I113	3.27	No	No	1	9	7
87	R:R:C120	R:R:D116	4.67	No	Yes	1	7	8
88	R:R:D116	R:R:Y390	11.49	Yes	Yes	1	8	8
89	L:L:?1	R:R:D116	11.59	Yes	Yes	1	0	8
90	R:R:I167	R:R:V117	3.07	Yes	No	0	8	8
91	R:R:S168	R:R:V117	3.23	No	No	0	8	8
92	L:L:?1	R:R:V117	7.27	Yes	No	0	0	8
93	R:R:L118	R:R:W161	6.83	No	Yes	0	6	9
94	R:R:F165	R:R:L118	4.87	No	No	0	5	6
95	R:R:L118	R:R:S168	4.5	No	No	0	6	8
96	R:R:C120	R:R:W358	5.22	No	Yes	1	7	8
97	L:L:?1	R:R:C120	4.84	Yes	No	1	0	7
98	R:R:G164	R:R:T121	3.64	No	No	0	8	8
99	R:R:I167	R:R:T121	7.6	Yes	No	0	8	8
100	R:R:A203	R:R:T121	5.03	No	No	0	8	8
101	R:R:H126	R:R:S122	4.18	Yes	Yes	1	8	8
102	R:R:S122	R:R:T160	3.2	Yes	No	1	8	8
103	R:R:S122	R:R:W161	18.53	Yes	Yes	1	8	9
104	R:R:I124	R:R:P207	3.39	No	Yes	0	8	9
105	R:R:F354	R:R:I124	6.28	Yes	No	1	9	8
106	R:R:I124	R:R:W358	8.22	No	Yes	1	8	8
107	R:R:T160	R:R:W125	3.64	No	No	0	8	7
108	R:R:I163	R:R:W125	16.44	No	No	0	5	7
109	R:R:P207	R:R:W125	13.51	Yes	No	0	9	7
110	R:R:H126	R:R:I157	5.3	Yes	No	1	8	8
111	R:R:H126	R:R:T160	6.85	Yes	No	1	8	8
112	R:R:H126	R:R:W161	4.23	Yes	Yes	1	8	9
113	R:R:F354	R:R:L127	3.65	Yes	No	1	9	8
114	R:R:L127	R:R:N396	6.87	No	Yes	1	8	9
115	R:R:L127	R:R:Y400	5.86	No	Yes	1	8	9
116	R:R:C128	R:R:P207	3.77	No	Yes	0	7	9
117	R:R:C128	R:R:M211	3.24	No	No	0	7	9
118	R:R:A129	R:R:L156	3.15	No	No	0	8	6
119	R:R:I130	R:R:R134	6.26	No	No	1	9	9
120	R:R:I130	R:R:Y400	4.84	No	Yes	1	9	9
121	R:R:A131	R:R:L214	3.15	No	No	0	9	7
122	R:R:A131	R:R:Y215	5.34	No	Yes	0	9	9
123	R:R:L132	R:R:W136	17.08	No	No	0	6	5
124	R:R:L132	R:R:L214	4.15	No	No	0	6	7
125	R:R:D133	R:R:R148	11.91	No	No	0	9	8
126	R:R:R134	R:R:Y215	4.12	No	Yes	1	9	9
127	R:R:R134	R:R:Y400	4.12	No	Yes	1	9	9
128	R:R:W136	R:R:Y135	4.82	No	Yes	0	5	9
129	R:R:T139	R:R:Y135	11.24	No	Yes	0	8	9
130	R:R:L214	R:R:Y135	5.86	No	Yes	0	7	9
131	R:R:R217	R:R:Y135	11.32	No	Yes	0	7	9
132	R:R:I218	R:R:Y135	3.63	No	Yes	0	9	9
133	R:R:R152	R:R:W136	3	No	No	0	7	5
134	R:R:I138	R:R:I218	4.42	No	No	0	9	9
135	R:R:D140	R:R:P141	3.22	No	No	0	7	8
136	R:R:D140	R:R:D143	6.65	No	No	0	7	6
137	R:R:D143	R:R:R152	10.72	No	No	0	6	7
138	R:R:R148	R:R:Y144	13.38	No	No	0	8	8
139	R:R:N146	R:R:V145	4.43	No	No	0	5	6
140	R:R:P150	R:R:T149	5.25	No	No	0	5	8
141	R:R:L162	R:R:L166	4.15	No	No	0	5	5
142	R:R:I167	R:R:Y198	3.63	Yes	No	0	8	5
143	R:R:I169	R:R:S168	3.1	No	No	0	6	8
144	R:R:P170	R:R:P171	5.84	Yes	No	2	8	7
145	R:R:P170	R:R:W175	6.76	Yes	Yes	2	8	6
146	R:R:P170	R:R:Y195	5.56	Yes	Yes	2	8	8
147	R:R:P170	R:R:Y198	5.56	Yes	No	0	8	5
148	R:R:P171	R:R:Y195	11.13	No	Yes	2	7	8
149	R:R:D192	R:R:W175	7.82	No	Yes	0	6	6
150	R:R:W175	R:R:Y195	7.72	Yes	Yes	2	6	8
151	R:R:D183	R:R:P184	6.44	No	No	0	1	1
152	R:R:A186	R:R:D183	4.63	No	No	0	4	1
153	R:R:I189	R:R:Y195	3.63	No	Yes	0	6	8
154	L:L:?1	R:R:I189	4.36	Yes	No	0	0	6
155	R:R:K191	R:R:P369	5.02	No	No	0	5	7
156	R:R:F370	R:R:H193	16.97	No	No	0	5	4
157	R:R:E372	R:R:H193	4.92	No	No	0	3	4
158	R:R:S199	R:R:Y195	8.9	No	Yes	0	8	8
159	R:R:P369	R:R:T196	8.74	No	No	0	7	7
160	R:R:F201	R:R:I197	3.77	No	No	0	5	7
161	R:R:F370	R:R:I197	5.02	No	No	0	5	7
162	L:L:?1	R:R:S199	3.67	Yes	No	0	0	8
163	R:R:F201	R:R:Y205	12.38	No	Yes	0	5	7
164	R:R:F204	R:R:Y205	9.28	Yes	Yes	1	8	7
165	R:R:F204	R:R:F354	6.43	Yes	Yes	1	8	9
166	R:R:F204	R:R:W358	3.01	Yes	Yes	1	8	8
167	R:R:F204	R:R:L359	4.87	Yes	Yes	0	8	7
168	R:R:F204	R:R:F362	22.51	Yes	Yes	1	8	7
169	R:R:F362	R:R:Y205	3.09	Yes	Yes	1	7	7
170	R:R:L366	R:R:Y205	8.21	No	Yes	0	7	7
171	R:R:I206	R:R:P207	3.39	No	Yes	0	6	9
172	R:R:L208	R:R:L212	4.15	No	No	0	7	6
173	R:R:F354	R:R:L208	3.65	Yes	No	0	9	7
174	R:R:M211	R:R:Y215	4.79	No	Yes	1	9	9
175	R:R:M211	R:R:M351	5.78	No	No	1	9	8
176	R:R:I218	R:R:Y215	3.63	No	Yes	0	9	9
177	R:R:L347	R:R:Y215	3.52	No	Yes	0	8	9
178	R:R:I350	R:R:Y215	7.25	No	Yes	0	8	9
179	R:R:M351	R:R:Y215	4.79	No	Yes	1	8	9
180	R:R:R217	R:R:R220	4.26	No	No	0	7	5
181	R:R:F219	R:R:R223	4.28	Yes	No	0	6	7
182	R:R:F219	R:R:L347	3.65	Yes	No	0	6	8
183	R:R:R223	R:R:R227	11.73	No	No	0	7	6
184	R:R:E340	R:R:R223	9.3	No	No	0	8	7
185	R:R:F224	R:R:R225	9.62	No	No	3	6	7
186	R:R:F224	R:R:K228	4.96	No	No	3	6	5
187	R:R:K228	R:R:R225	7.43	No	No	3	5	7
188	R:R:I226	R:R:R339	5.01	No	No	0	6	7
189	R:R:E340	R:R:I226	9.56	No	No	0	8	6
190	R:R:T229	R:R:V230	3.17	No	No	0	4	3
191	R:R:E326	R:R:K324	18.9	No	No	0	3	1
192	R:R:K324	R:R:R327	8.66	No	No	0	1	3
193	R:R:E330	R:R:R333	10.47	No	No	0	4	4
194	R:R:M335	R:R:R339	7.44	No	No	0	4	7
195	R:R:I350	R:R:T346	3.04	No	No	0	8	8
196	R:R:I399	R:R:T353	4.56	No	No	0	8	7
197	R:R:F354	R:R:W358	4.01	Yes	Yes	1	9	8
198	R:R:I355	R:R:L359	4.28	No	Yes	0	7	7
199	R:R:C357	R:R:N392	7.87	No	No	0	8	9
200	R:R:F361	R:R:W358	7.02	Yes	Yes	1	8	8
201	R:R:F362	R:R:W358	9.02	Yes	Yes	1	7	8
202	R:R:G389	R:R:W358	8.44	No	Yes	0	8	8
203	R:R:N392	R:R:W358	10.17	No	Yes	0	9	8
204	R:R:L359	R:R:P360	3.28	Yes	No	0	7	9
205	R:R:I363	R:R:L359	7.14	No	Yes	0	7	7
206	R:R:I385	R:R:P360	3.39	No	No	0	6	9
207	R:R:F361	R:R:F362	12.86	Yes	Yes	1	8	7
208	R:R:F361	R:R:N386	3.62	Yes	No	1	8	7
209	L:L:?1	R:R:F361	17.84	Yes	Yes	1	0	8
210	L:L:?1	R:R:F362	6.69	Yes	Yes	1	0	7
211	R:R:L368	R:R:V364	2.98	No	No	0	4	6
212	R:R:M377	R:R:V364	3.04	Yes	No	0	4	6
213	R:R:C371	R:R:C375	3.64	No	No	0	5	4
214	R:R:H376	R:R:P378	4.58	No	No	0	2	7
215	R:R:M377	R:R:P378	5.03	Yes	No	0	4	7
216	R:R:L381	R:R:M377	4.24	No	Yes	0	6	4
217	R:R:G382	R:R:M377	3.49	No	Yes	0	4	4
218	R:R:I384	R:R:L380	4.28	No	No	0	4	3
219	L:L:?1	R:R:N386	4.19	Yes	No	1	0	7
220	R:R:W387	R:R:Y390	7.72	No	Yes	0	8	8
221	L:L:?1	R:R:Y390	12.16	Yes	Yes	1	0	8
222	R:R:N392	R:R:N396	12.26	No	Yes	0	9	9
223	R:R:N396	R:R:Y400	4.65	Yes	Yes	1	9	9
224	R:R:F403	R:R:V398	5.24	No	No	0	8	6
225	R:R:I399	R:R:Y400	8.46	No	Yes	0	8	9
226	R:R:A401	R:R:F407	8.32	No	Yes	0	8	8
227	R:R:F411	R:R:Y402	10.32	No	Yes	0	8	6
228	R:R:D406	R:R:N404	4.04	No	No	0	7	9
229	R:R:F407	R:R:N404	8.46	Yes	No	0	8	9
230	R:R:L43	R:R:T39	2.95	No	Yes	0	7	5
231	R:R:L99	R:R:T103	2.95	No	No	0	5	5
232	R:R:L104	R:R:T103	2.95	No	No	0	7	5
233	R:R:L366	R:R:T200	2.95	No	No	0	7	7
234	R:R:L395	R:R:T353	2.95	No	No	0	6	7
235	R:R:I414	R:R:I415	2.94	No	No	0	7	7
236	R:R:I157	R:R:L74	2.85	No	Yes	0	8	8
237	R:R:I169	R:R:L173	2.85	No	No	0	6	6
238	R:R:I206	R:R:L210	2.85	No	No	0	6	7
239	R:R:I142	R:R:N146	2.83	No	No	0	6	5
240	R:R:G194	R:R:W175	2.81	No	Yes	0	5	6
241	R:R:P397	R:R:Y402	2.78	No	Yes	0	9	6
242	R:R:L394	R:R:L46	2.77	No	No	0	7	7
243	R:R:A93	R:R:F112	2.77	No	Yes	0	7	6
244	R:R:D110	R:R:M172	2.77	No	No	0	7	6
245	R:R:K405	R:R:Q408	2.71	No	No	0	6	9
246	R:R:K412	R:R:Q408	2.71	No	No	0	6	9
247	R:R:C56	R:R:Y402	2.69	No	Yes	0	8	6
248	R:R:A137	R:R:Y144	2.67	No	No	0	8	8
249	R:R:D183	R:R:D185	2.66	No	No	0	1	4
250	R:R:F219	R:R:V344	2.62	Yes	No	0	6	8
251	R:R:D110	R:R:Q106	2.61	No	No	0	7	4
252	R:R:R151	R:R:T149	2.59	No	No	0	6	8
253	R:R:F219	R:R:T343	2.59	Yes	No	0	6	8
254	R:R:F403	R:R:I399	2.51	No	No	0	8	8
255	R:R:A79	R:R:G76	1.95	No	No	0	9	6
256	R:R:G44	R:R:I47	1.76	No	No	0	4	7
257	R:R:G202	R:R:I167	1.76	No	Yes	0	5	8
258	R:R:G352	R:R:I355	1.76	No	No	0	6	7
259	R:R:G382	R:R:I385	1.76	No	No	0	4	6
260	R:R:C371	R:R:S374	1.72	No	No	0	5	5
261	R:R:A155	R:R:S158	1.71	No	No	0	3	5
262	R:R:A336	R:R:V230	1.7	No	No	0	5	3
263	R:R:C49	R:R:T45	1.69	No	No	0	5	4
264	R:R:A186	R:R:T188	1.68	No	No	0	4	5
265	R:R:A365	R:R:T200	1.68	No	No	0	8	7
266	R:R:A222	R:R:T343	1.68	No	No	0	8	8
267	R:R:L90	R:R:P91	1.64	Yes	No	0	8	9
268	R:R:L368	R:R:P369	1.64	No	No	0	4	7
269	R:R:S40	R:R:V98	1.62	No	No	0	5	6
270	R:R:A221	R:R:I138	1.62	No	No	0	6	9
271	R:R:A336	R:R:I226	1.62	No	No	0	5	6
272	R:R:A114	R:R:M172	1.61	No	No	0	7	6
273	R:R:C49	R:R:L394	1.59	No	No	0	5	7
274	R:R:C375	R:R:L368	1.59	No	No	0	4	4
275	R:R:A55	R:R:L83	1.58	No	Yes	0	5	8
276	R:R:A71	R:R:N69	1.56	No	No	0	8	8
277	R:R:I38	R:R:V37	1.54	No	No	0	3	5
278	R:R:I38	R:R:T39	1.52	No	Yes	0	3	5
279	R:R:I349	R:R:T353	1.52	No	No	0	7	7
280	R:R:F219	R:R:G216	1.51	Yes	No	0	6	3
281	R:R:L46	R:R:S391	1.5	No	No	0	7	5
282	R:R:L209	R:R:V213	1.49	No	No	0	5	5
283	R:R:D192	R:R:S190	1.47	No	No	0	6	6
284	R:R:I349	R:R:K345	1.45	No	No	0	7	7
285	R:R:E372	R:R:S373	1.44	No	No	0	3	3
286	R:R:I414	R:R:L63	1.43	No	No	0	7	6
287	R:R:I163	R:R:L159	1.43	No	No	0	5	3
288	R:R:I355	R:R:L356	1.43	No	No	0	7	5
289	R:R:G105	R:R:W102	1.41	No	Yes	0	7	9
290	R:R:G174	R:R:W175	1.41	No	Yes	0	5	6
291	R:R:D140	R:R:I142	1.4	No	No	0	7	6
292	R:R:K147	R:R:N146	1.4	No	No	0	5	5
293	R:R:K324	R:R:N325	1.4	No	No	0	1	5
294	R:R:K405	R:R:N404	1.4	No	No	0	6	9
295	R:R:A338	R:R:R341	1.38	No	No	0	5	6
296	R:R:E64	R:R:I414	1.37	No	No	0	7	7
297	R:R:R217	R:R:V213	1.31	No	No	0	7	5
298	R:R:F48	R:R:L52	1.22	No	No	0	4	4
299	R:R:L337	R:R:R333	1.21	No	No	0	5	4
300	R:R:L166	R:R:Y198	1.17	No	No	0	5	5
301	R:R:F224	R:R:R227	1.07	No	No	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T39	3.47	4	0	5
2	R:R:L74	3.555	4	0	8
3	R:R:L78	5.578	5	1	9
4	R:R:D82	7.264	5	1	9
5	R:R:L83	3.63	4	0	8
6	R:R:L90	4.388	5	0	8
7	R:R:W102	6.18571	7	1	9
8	R:R:F112	6.245	4	1	6
9	R:R:D116	9.1275	4	1	8
10	R:R:S122	8.475	4	1	8
11	R:R:H126	6.40714	7	1	8
12	R:R:Y135	7.374	5	0	9
13	R:R:W161	8.78	5	1	9
14	R:R:I167	4.015	4	0	8
15	R:R:P170	5.93	4	2	8
16	R:R:W175	5.304	5	2	6
17	R:R:Y195	7.388	5	2	8
18	R:R:F204	9.22	5	1	8
19	R:R:Y205	8.24	4	1	7
20	R:R:P207	6.015	4	0	9
21	R:R:Y215	4.77714	7	1	9
22	R:R:F219	2.93	5	0	6
23	R:R:F354	4.804	5	1	9
24	R:R:W358	6.88875	8	1	8
25	R:R:L359	4.8925	4	0	7
26	R:R:F361	10.335	4	1	8
27	R:R:F362	10.834	5	1	7
28	R:R:M377	3.95	4	0	4
29	R:R:Y390	8.438	5	1	8
30	R:R:N396	7.746	5	1	9
31	R:R:Y400	5.01143	7	1	9
32	R:R:Y402	5.038	5	0	6
33	R:R:F407	8	5	0	8
34	L:L:?1	9.11273	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q36	R:R:T32	14.0222	5.67	No	No	0	4	4
2	R:R:Q36	R:R:Y35	18.6862	3.38	No	No	0	4	4
3	R:R:T39	R:R:Y35	27.8517	6.24	Yes	No	0	5	4
4	R:R:I38	R:R:T39	14.0222	1.52	No	Yes	0	3	5
5	R:R:T39	R:R:V98	10.1264	3.17	Yes	No	0	5	6
6	R:R:L43	R:R:T39	55.4362	2.95	No	Yes	0	7	5
7	R:R:L43	R:R:W387	64.4668	13.67	No	No	0	7	8
8	R:R:L90	R:R:Y390	21.8248	7.03	Yes	Yes	0	8	8
9	R:R:W387	R:R:Y390	42.1382	7.72	No	Yes	0	8	8
10	R:R:L83	R:R:N54	10.1154	5.49	Yes	No	0	8	9
11	R:R:D82	R:R:N54	51.6808	6.73	Yes	No	0	9	9
12	R:R:D82	R:R:S393	22.0258	8.83	Yes	No	0	9	9
13	R:R:S393	R:R:V85	21.5633	8.08	No	No	0	9	8
14	R:R:L90	R:R:V85	21.4504	2.98	Yes	No	0	8	8
15	R:R:P397	R:R:Y402	40.1586	2.78	No	Yes	0	9	6
16	R:R:N54	R:R:P397	41.4609	8.15	No	No	0	9	9
17	R:R:V57	R:R:Y402	30.8885	5.05	No	Yes	0	9	6
18	R:R:A401	R:R:V57	26.833	5.09	No	No	0	8	9
19	R:R:Q97	R:R:W387	27.502	13.14	No	No	0	7	8
20	L:L:?1	R:R:Q97	31.6236	9.75	Yes	No	0	0	7
21	L:L:?1	R:R:V117	28.8125	7.27	Yes	No	0	0	8
22	R:R:S168	R:R:V117	12.2877	3.23	No	No	0	8	8
23	R:R:L118	R:R:S168	11.9242	4.5	No	No	0	6	8
24	R:R:L118	R:R:W161	11.8582	6.83	No	Yes	0	6	9
25	L:L:?1	R:R:Y390	39.2583	12.16	Yes	Yes	1	0	8
26	R:R:A401	R:R:F407	25.4701	8.32	No	Yes	0	8	8
27	R:R:F407	R:R:L67	11.5388	9.74	Yes	No	0	8	8
28	R:R:D133	R:R:L74	10.3494	4.07	No	Yes	0	9	8
29	R:R:I157	R:R:L74	14.3361	2.85	No	Yes	0	8	8
30	R:R:H126	R:R:I157	15.2777	5.3	Yes	No	1	8	8
31	R:R:H126	R:R:L78	20.707	7.71	Yes	Yes	1	8	9
32	R:R:D82	R:R:L78	17.4307	6.79	Yes	Yes	1	9	9
33	R:R:H126	R:R:W161	11.7398	4.23	Yes	Yes	1	8	9
34	R:R:L78	R:R:Y400	18.9477	3.52	Yes	Yes	1	9	9
35	R:R:N396	R:R:Y400	49.481	4.65	Yes	Yes	1	9	9
36	R:R:D82	R:R:N396	36.461	8.08	Yes	Yes	1	9	9
37	R:R:L127	R:R:Y400	58.2886	5.86	No	Yes	1	8	9
38	R:R:F354	R:R:L127	65.9949	3.65	Yes	No	1	9	8
39	R:R:F204	R:R:F354	26.5218	6.43	Yes	Yes	1	8	9
40	R:R:F204	R:R:F362	19.4488	22.51	Yes	Yes	1	8	7
41	L:L:?1	R:R:F362	65.2845	6.69	Yes	Yes	1	0	7
42	R:R:F354	R:R:W358	42.2621	4.01	Yes	Yes	1	9	8
43	R:R:F362	R:R:W358	45.5384	9.02	Yes	Yes	1	7	8
44	R:R:N392	R:R:N396	65.3203	12.26	No	Yes	0	9	9
45	R:R:N392	R:R:W358	66.6088	10.17	No	Yes	0	9	8
46	R:R:C120	R:R:W358	54.1009	5.22	No	Yes	1	7	8
47	L:L:?1	R:R:C120	42.9724	4.84	Yes	No	1	0	7
48	R:R:F361	R:R:W358	44.0544	7.02	Yes	Yes	1	8	8
49	L:L:?1	R:R:F361	42.9449	17.84	Yes	Yes	1	0	8
50	R:R:C120	R:R:D116	10.7569	4.67	No	Yes	1	7	8
51	R:R:L104	R:R:W102	26.3567	6.83	No	Yes	0	7	9
52	R:R:L104	R:R:T103	21.4889	2.95	No	No	0	7	5
53	L:L:?1	R:R:Y96	42.9449	17.88	Yes	No	0	0	6
54	R:R:K101	R:R:T103	15.2611	6.01	No	No	0	5	5
55	R:R:D185	R:R:K101	12.7309	9.68	No	No	0	4	5
56	R:R:I167	R:R:V117	21.7037	3.07	Yes	No	0	8	8
57	R:R:I124	R:R:P207	42.6035	3.39	No	Yes	0	8	9
58	R:R:I124	R:R:W358	41.9234	8.22	No	Yes	1	8	8
59	R:R:C128	R:R:P207	35.4313	3.77	No	Yes	0	7	9
60	R:R:C128	R:R:M211	34.2281	3.24	No	No	0	7	9
61	R:R:R134	R:R:Y400	100	4.12	No	Yes	1	9	9
62	R:R:R134	R:R:Y215	98.0452	4.12	No	Yes	1	9	9
63	R:R:M211	R:R:Y215	32.5569	4.79	No	Yes	1	9	9
64	R:R:I218	R:R:Y215	56.2099	3.63	No	Yes	0	9	9
65	R:R:I218	R:R:Y135	46.9343	3.63	No	Yes	0	9	9
66	R:R:W136	R:R:Y135	28.2509	4.82	No	Yes	0	5	9
67	R:R:R217	R:R:Y135	12.7502	11.32	No	Yes	0	7	9
68	R:R:R152	R:R:W136	25.1425	3	No	No	0	7	5
69	R:R:D140	R:R:D143	19.1102	6.65	No	No	0	7	6
70	R:R:D143	R:R:R152	22.2736	10.72	No	No	0	6	7
71	R:R:D140	R:R:I142	12.7612	1.4	No	No	0	7	6
72	R:R:I189	R:R:Y195	19.0744	3.63	No	Yes	0	6	8
73	L:L:?1	R:R:I189	21.3265	4.36	Yes	No	0	0	6
74	R:R:S199	R:R:Y195	19.0744	8.9	No	Yes	0	8	8
75	L:L:?1	R:R:S199	21.354	3.67	Yes	No	0	0	8
76	R:R:W175	R:R:Y195	23.9779	7.72	Yes	Yes	2	6	8
77	R:R:D183	R:R:D185	10.1952	2.66	No	No	0	1	4
78	R:R:G382	R:R:M377	12.8493	3.49	No	Yes	0	4	4
79	R:R:G382	R:R:I385	13.8845	1.76	No	No	0	4	6
80	R:R:I385	R:R:P360	14.9142	3.39	No	No	0	6	9
81	R:R:L359	R:R:P360	15.9384	3.28	Yes	No	0	7	9
82	R:R:F204	R:R:L359	20.9768	4.87	Yes	Yes	0	8	7
83	R:R:L347	R:R:Y215	56.3503	3.52	No	Yes	0	8	9
84	R:R:F219	R:R:L347	53.2502	3.65	Yes	No	0	6	8
85	R:R:F219	R:R:R223	37.6614	4.28	Yes	No	0	6	7
86	R:R:R223	R:R:R227	12.7392	11.73	No	No	0	7	6
87	R:R:E340	R:R:R223	21.9377	9.3	No	No	0	8	7
88	R:R:E340	R:R:I226	19.0689	9.56	No	No	0	8	6
89	R:R:I399	R:R:Y400	17.0728	8.46	No	Yes	0	8	9
90	R:R:W102	R:R:Y96	40.7368	7.72	Yes	No	0	9	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D116	R:R:V89	8.76	1	Yes	No	8	8	1	2
R:R:V89	R:R:Y390	3.79	1	No	Yes	8	8	2	1
R:R:L90	R:R:Y390	7.03	0	Yes	Yes	8	8	2	1
R:R:W102	R:R:Y96	7.72	1	Yes	No	9	6	2	1
L:L:?1	R:R:Y96	17.88	1	Yes	No	0	6	0	1
R:R:A383	R:R:Q97	4.55	0	No	No	6	7	2	1
R:R:Q97	R:R:W387	13.14	0	No	No	7	8	1	2
L:L:?1	R:R:Q97	9.75	1	Yes	No	0	7	0	1
R:R:C120	R:R:D116	4.67	1	No	Yes	7	8	1	1
R:R:D116	R:R:Y390	11.49	1	Yes	Yes	8	8	1	1
L:L:?1	R:R:D116	11.59	1	Yes	Yes	0	8	0	1
R:R:I167	R:R:V117	3.07	0	Yes	No	8	8	2	1
R:R:S168	R:R:V117	3.23	0	No	No	8	8	2	1
L:L:?1	R:R:V117	7.27	1	Yes	No	0	8	0	1
R:R:C120	R:R:W358	5.22	1	No	Yes	7	8	1	2
L:L:?1	R:R:C120	4.84	1	Yes	No	0	7	0	1
R:R:I189	R:R:Y195	3.63	0	No	Yes	6	8	1	2
L:L:?1	R:R:I189	4.36	1	Yes	No	0	6	0	1
R:R:S199	R:R:Y195	8.9	0	No	Yes	8	8	1	2
L:L:?1	R:R:S199	3.67	1	Yes	No	0	8	0	1
R:R:F204	R:R:Y205	9.28	1	Yes	Yes	8	7	2	2
R:R:F204	R:R:W358	3.01	1	Yes	Yes	8	8	2	2
R:R:F204	R:R:F362	22.51	1	Yes	Yes	8	7	2	1
R:R:F362	R:R:Y205	3.09	1	Yes	Yes	7	7	1	2
R:R:F361	R:R:W358	7.02	1	Yes	Yes	8	8	1	2
R:R:F362	R:R:W358	9.02	1	Yes	Yes	7	8	1	2
R:R:F361	R:R:F362	12.86	1	Yes	Yes	8	7	1	1
R:R:F361	R:R:N386	3.62	1	Yes	No	8	7	1	1
L:L:?1	R:R:F361	17.84	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F362	6.69	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N386	4.19	1	Yes	No	0	7	0	1
R:R:W387	R:R:Y390	7.72	0	No	Yes	8	8	2	1
L:L:?1	R:R:Y390	12.16	1	Yes	Yes	0	8	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8PJK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	268
Number of Links	301
Number of Hubs	34
Number of Links mediated by Hubs	145
Number of Communities	3
Number of Nodes involved in Communities	44
Number of Links involved in Communities	69

Path Summary
Number Of Nodes in MetaPath	91
Number Of Links MetaPath	90
Number of Shortest Paths	97635
Length Of Smallest Path	3
Average Path Length	13.8011
Length of Longest Path	26
Minimum Path Strength	1.4
Average Path Strength	6.31258
Maximum Path Strength	17.685
Minimum Path Correlation	0.7
Average Path Correlation	0.936045
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	50.3574
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.3612
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cation binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • signaling receptor binding • receptor-receptor interaction • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • behavior • multicellular organismal process • exploration behavior • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • regulation of tube diameter • system process • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • cell-cell signaling • gamma-aminobutyric acid signaling pathway • regulation of behavior • serotonin metabolic process • indole-containing compound metabolic process • serotonin receptor signaling pathway • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • monoatomic ion transport • serotonin secretion • regulation of monoatomic ion transport • regulation of serotonin secretion • serotonin transport • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • somatodendritic compartment • dendrite • dendritic tree • D2 dopamine receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • carbohydrate derivative binding • ribonucleotide binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • establishment of protein localization • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • amide transport • negative regulation of cellular process • negative regulation of protein localization • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ZL9
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ZL9
Name	6-[3-[2-(2-methoxyphenoxy)ethylamino]propoxy]-4~{H}-1,4-benzoxazin-3-one
Synonyms
Identifier
Formula	C20 H24 N2 O5
Molecular Weight	372.415
SMILES
PubChem	171392444
Formal Charge	0
Total Atoms	51
Total Chiral Atoms	0
Total Bonds	53
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08908
Sequence	>8PJK_nogp_Chain_R T V S Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E R S L Q N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N K W T L G Q V T C D L F I A L D V L C C T S S I W H L C A I A L D R Y W A I T D P I D Y V N K R T P R R A A A L I S L T W L I G F L I S I P P M L G W R S D P D A C T I S K D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K T V K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C E S S C H M P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F Q N A F K K I I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7E2X	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2X (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-	Gi1/β1/γ2	3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-		3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	8W8B	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-	Gi1/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8B (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8JSP	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-	Gi1/β1/γ2	3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSP (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-		3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8FY8	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-	Gi1/β1/γ1	2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FY8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-		2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-	Gi1/β1/γ1	2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-		2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-	Gi1/β1/γ1	2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-		2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-	Gi1/β1/γ1	2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-		2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gi1/β1/γ1	2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8JT6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-	Gi1/β1/γ2	3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8JT6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-		3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8PJK	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-	Gi1/β1/γ1	2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PJK (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-		2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gi1/β1/γ1	2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	9GL2	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gs/β1/γ2	3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9GL2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9DYF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-	Gi1/β1/γ2	2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-		2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-	Go/β1/γ2	2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-		2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Go/β1/γ2	2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851

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