psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:A93	5.15	Yes	No	0	0	7
2	L:L:?1	R:R:Y96	6.9	Yes	No	1	0	6
3	L:L:?1	R:R:W102	5.21	Yes	Yes	1	0	9
4	L:L:?1	R:R:F112	3.98	Yes	No	1	0	6
5	L:L:?1	R:R:D116	19.52	Yes	No	1	0	8
6	L:L:?1	R:R:V117	6.82	Yes	No	0	0	8
7	L:L:?1	R:R:C120	6.23	Yes	No	0	0	7
8	L:L:?1	R:R:C187	4.15	Yes	No	1	0	9
9	L:L:?1	R:R:F361	14.33	Yes	No	1	0	8
10	L:L:?1	R:R:F362	7.17	Yes	Yes	1	0	7
11	L:L:?1	R:R:N386	7.18	Yes	No	0	0	7
12	L:L:?1	R:R:Y390	8.43	Yes	Yes	1	0	8
13	R:R:I38	R:R:Y35	10.88	No	No	0	3	4
14	R:R:T39	R:R:V98	3.17	No	No	0	5	6
15	R:R:L41	R:R:S40	3	No	No	0	4	5
16	R:R:L43	R:R:W387	11.39	No	Yes	0	7	8
17	R:R:L46	R:R:S391	3	No	No	0	7	5
18	R:R:I47	R:R:L90	4.28	No	No	0	7	8
19	R:R:A50	R:R:S86	3.42	No	No	0	8	8
20	R:R:S86	R:R:V51	3.23	No	No	0	8	7
21	R:R:C56	R:R:L52	3.17	No	No	0	8	4
22	R:R:G53	R:R:Y402	4.35	No	Yes	0	9	6
23	R:R:D82	R:R:N54	6.73	Yes	No	0	9	9
24	R:R:N54	R:R:P397	11.4	No	No	0	9	9
25	R:R:A79	R:R:V57	3.39	No	No	0	9	9
26	R:R:A401	R:R:V57	3.39	No	No	0	8	9
27	R:R:V58	R:R:V80	3.21	No	No	0	7	7
28	R:R:A60	R:R:F411	4.16	No	No	0	8	8
29	R:R:F407	R:R:I61	6.28	Yes	No	0	8	8
30	R:R:E64	R:R:L67	3.98	Yes	Yes	4	7	8
31	R:R:A410	R:R:E64	3.02	No	Yes	4	8	7
32	R:R:E64	R:R:K413	6.75	Yes	No	0	7	6
33	R:R:L67	R:R:N72	4.12	Yes	No	4	8	9
34	R:R:F407	R:R:L67	6.09	Yes	Yes	4	8	8
35	R:R:A410	R:R:L67	3.15	No	Yes	4	8	8
36	R:R:Q68	R:R:Y73	4.51	No	No	0	8	6
37	R:R:N69	R:R:N72	9.54	No	No	0	8	9
38	R:R:R148	R:R:V70	14.38	Yes	No	0	8	7
39	R:R:F407	R:R:N72	7.25	Yes	No	4	8	9
40	R:R:P150	R:R:Y73	4.17	No	No	0	5	6
41	R:R:D133	R:R:L74	4.07	No	Yes	0	9	8
42	R:R:A153	R:R:L74	3.15	No	Yes	0	7	8
43	R:R:L156	R:R:L74	4.15	No	Yes	0	6	8
44	R:R:H126	R:R:S77	11.16	Yes	No	3	8	9
45	R:R:I157	R:R:S77	9.29	No	No	3	8	9
46	R:R:D82	R:R:L78	5.43	Yes	No	2	9	9
47	R:R:L127	R:R:L78	4.15	No	No	2	8	9
48	R:R:L78	R:R:N396	8.24	No	Yes	2	9	9
49	R:R:S122	R:R:T81	4.8	No	No	3	8	9
50	R:R:H126	R:R:T81	8.21	Yes	No	3	8	9
51	R:R:T81	R:R:W161	3.64	No	Yes	3	9	9
52	R:R:D82	R:R:S123	4.42	Yes	No	0	9	9
53	R:R:D82	R:R:S393	7.36	Yes	No	0	9	9
54	R:R:D82	R:R:N396	8.08	Yes	Yes	2	9	9
55	R:R:L83	R:R:S86	4.5	No	No	0	8	8
56	R:R:M84	R:R:W161	3.49	No	Yes	0	7	9
57	R:R:C119	R:R:V85	3.42	No	No	0	7	8
58	R:R:S393	R:R:V85	6.46	No	No	0	9	8
59	R:R:L88	R:R:V87	4.47	No	No	0	6	6
60	R:R:D116	R:R:V89	7.3	No	No	1	8	8
61	R:R:V89	R:R:Y390	3.79	No	Yes	1	8	8
62	R:R:L90	R:R:Y390	8.21	No	Yes	0	8	8
63	R:R:M92	R:R:W102	3.49	No	Yes	1	6	9
64	R:R:L104	R:R:M92	4.24	Yes	No	1	7	6
65	R:R:F112	R:R:M92	13.68	No	No	1	6	6
66	R:R:L95	R:R:L99	4.15	No	No	0	6	5
67	R:R:W102	R:R:Y96	7.72	Yes	No	1	9	6
68	R:R:D185	R:R:Y96	9.2	No	No	0	4	6
69	R:R:A383	R:R:Q97	4.55	No	No	0	6	7
70	R:R:L99	R:R:T103	2.95	No	No	0	5	5
71	R:R:K101	R:R:T103	4.5	No	No	0	5	5
72	R:R:K101	R:R:P184	3.35	No	No	0	5	1
73	R:R:L104	R:R:W102	10.25	Yes	Yes	1	7	9
74	R:R:T108	R:R:W102	4.85	No	Yes	1	6	9
75	R:R:C109	R:R:W102	3.92	Yes	Yes	1	9	9
76	R:R:F112	R:R:W102	5.01	No	Yes	1	6	9
77	R:R:C187	R:R:W102	14.37	No	Yes	1	9	9
78	R:R:L104	R:R:T103	2.95	Yes	No	0	7	5
79	R:R:L104	R:R:T108	5.9	Yes	No	1	7	6
80	R:R:G105	R:R:T108	3.64	No	No	0	7	6
81	R:R:Q106	R:R:R181	7.01	No	No	0	4	4
82	R:R:C109	R:R:I113	3.27	Yes	No	0	9	7
83	R:R:C109	R:R:C187	5.46	Yes	No	1	9	9
84	R:R:D110	R:R:R176	7.15	Yes	No	0	7	6
85	R:R:L111	R:R:L115	6.92	No	No	0	5	5
86	R:R:D116	R:R:Y390	10.34	No	Yes	1	8	8
87	R:R:S168	R:R:V117	3.23	No	No	0	8	8
88	R:R:L118	R:R:W161	4.56	No	Yes	0	6	9
89	R:R:F165	R:R:L118	9.74	No	No	0	5	6
90	R:R:L118	R:R:S168	6.01	No	No	0	6	8
91	R:R:C120	R:R:W358	5.22	No	Yes	0	7	8
92	R:R:G164	R:R:T121	3.64	No	No	0	8	8
93	R:R:A203	R:R:T121	5.03	No	No	0	8	8
94	R:R:S122	R:R:T160	3.2	No	No	0	8	8
95	R:R:S122	R:R:W161	17.3	No	Yes	3	8	9
96	R:R:I124	R:R:P207	3.39	No	No	0	8	9
97	R:R:I124	R:R:W358	9.4	No	Yes	0	8	8
98	R:R:T160	R:R:W125	3.64	No	No	0	8	7
99	R:R:I163	R:R:W125	16.44	No	No	0	5	7
100	R:R:P207	R:R:W125	13.51	No	No	0	9	7
101	R:R:H126	R:R:I157	5.3	Yes	No	3	8	8
102	R:R:H126	R:R:T160	17.8	Yes	No	0	8	8
103	R:R:H126	R:R:W161	3.17	Yes	Yes	3	8	9
104	R:R:L127	R:R:N396	6.87	No	Yes	2	8	9
105	R:R:L127	R:R:Y400	4.69	No	Yes	2	8	9
106	R:R:C128	R:R:L210	4.76	No	No	0	7	7
107	R:R:A129	R:R:L156	3.15	No	No	0	8	6
108	R:R:I130	R:R:R134	7.52	No	No	2	9	9
109	R:R:I130	R:R:Y400	4.84	No	Yes	2	9	9
110	R:R:A131	R:R:Y215	4	No	Yes	0	9	9
111	R:R:L132	R:R:W136	10.25	No	No	0	6	5
112	R:R:L132	R:R:L214	4.15	No	No	0	6	7
113	R:R:D133	R:R:R148	11.91	No	Yes	0	9	8
114	R:R:R134	R:R:Y215	6.17	No	Yes	0	9	9
115	R:R:R134	R:R:Y400	6.17	No	Yes	2	9	9
116	R:R:W136	R:R:Y135	6.75	No	Yes	0	5	9
117	R:R:T139	R:R:Y135	7.49	No	Yes	0	8	9
118	R:R:L214	R:R:Y135	5.86	No	Yes	0	7	9
119	R:R:R217	R:R:Y135	11.32	No	Yes	0	7	9
120	R:R:A137	R:R:I138	3.25	No	No	0	8	9
121	R:R:D140	R:R:P141	3.22	No	No	0	7	8
122	R:R:D140	R:R:D143	7.98	No	No	0	7	6
123	R:R:D143	R:R:K147	4.15	No	No	0	6	5
124	R:R:D143	R:R:R152	10.72	No	No	0	6	7
125	R:R:R148	R:R:Y144	11.32	Yes	No	0	8	8
126	R:R:N146	R:R:V145	2.96	No	No	0	5	6
127	R:R:R148	R:R:R152	7.46	Yes	No	0	8	7
128	R:R:R151	R:R:T149	6.47	No	No	0	6	8
129	R:R:F165	R:R:I169	6.28	No	No	0	5	6
130	R:R:I167	R:R:Y198	3.63	No	No	0	8	5
131	R:R:I169	R:R:S168	4.64	No	No	0	6	8
132	R:R:I169	R:R:P170	5.08	No	No	0	6	8
133	R:R:P170	R:R:P171	5.84	No	No	0	8	7
134	R:R:P171	R:R:Y195	4.17	No	Yes	0	7	8
135	R:R:G174	R:R:W175	4.22	No	No	0	5	6
136	R:R:D180	R:R:P178	3.22	No	No	0	4	5
137	R:R:I189	R:R:Y195	7.25	No	Yes	0	6	8
138	R:R:K191	R:R:P369	3.35	No	No	0	5	7
139	R:R:F370	R:R:H193	18.1	No	No	0	5	4
140	R:R:S199	R:R:Y195	6.36	No	Yes	0	8	8
141	R:R:T196	R:R:T200	3.14	No	Yes	0	7	7
142	R:R:P369	R:R:T196	10.49	No	No	0	7	7
143	R:R:F370	R:R:T196	3.89	No	No	0	5	7
144	R:R:F201	R:R:I197	5.02	No	No	0	5	7
145	R:R:T200	R:R:Y205	4.99	Yes	Yes	1	7	7
146	R:R:L366	R:R:T200	4.42	No	Yes	1	7	7
147	R:R:F201	R:R:Y205	5.16	No	Yes	0	5	7
148	R:R:F204	R:R:Y205	8.25	Yes	Yes	1	8	7
149	R:R:F204	R:R:L208	4.87	Yes	No	1	8	7
150	R:R:F204	R:R:F354	4.29	Yes	No	1	8	9
151	R:R:F204	R:R:W358	3.01	Yes	Yes	1	8	8
152	R:R:F204	R:R:L359	3.65	Yes	Yes	0	8	7
153	R:R:F204	R:R:F362	20.36	Yes	Yes	1	8	7
154	R:R:L366	R:R:Y205	7.03	No	Yes	1	7	7
155	R:R:I206	R:R:P207	3.39	No	No	0	6	9
156	R:R:L208	R:R:L212	4.15	No	No	0	7	6
157	R:R:F354	R:R:L208	3.65	No	No	1	9	7
158	R:R:F354	R:R:M211	4.98	No	No	0	9	9
159	R:R:R217	R:R:V213	3.92	No	No	0	7	5
160	R:R:L347	R:R:Y215	3.52	No	Yes	0	8	9
161	R:R:I350	R:R:Y215	6.04	No	Yes	0	8	9
162	R:R:M351	R:R:Y215	3.59	No	Yes	0	8	9
163	R:R:F219	R:R:R223	5.34	Yes	Yes	0	6	7
164	R:R:F219	R:R:T343	3.89	Yes	No	0	6	8
165	R:R:F219	R:R:L347	3.65	Yes	No	0	6	8
166	R:R:R223	R:R:R227	19.19	Yes	No	6	7	6
167	R:R:E340	R:R:R223	6.98	No	Yes	6	8	7
168	R:R:F224	R:R:R225	5.34	No	No	0	6	7
169	R:R:F224	R:R:K228	3.72	No	No	0	6	5
170	R:R:I226	R:R:R339	5.01	No	No	0	6	7
171	R:R:E340	R:R:R227	12.79	No	No	6	8	6
172	R:R:E330	R:R:R333	20.93	No	No	0	4	4
173	R:R:E330	R:R:K334	8.1	No	No	0	4	5
174	R:R:M335	R:R:R339	4.96	No	No	0	4	7
175	R:R:L337	R:R:R341	13.36	No	No	0	5	6
176	R:R:K345	W:W:?1	9.44	No	Yes	0	7	0
177	R:R:T346	W:W:?1	6.91	No	Yes	0	8	0
178	R:R:I349	R:R:I399	4.42	No	No	0	7	8
179	R:R:I349	W:W:?1	3.82	No	Yes	0	7	0
180	R:R:L395	R:R:T353	2.95	No	No	0	6	7
181	R:R:I399	R:R:T353	6.08	No	No	0	8	7
182	R:R:I355	R:R:L359	4.28	No	Yes	0	7	7
183	R:R:C357	R:R:N392	3.15	No	No	0	8	9
184	R:R:F361	R:R:W358	7.02	No	Yes	1	8	8
185	R:R:F362	R:R:W358	6.01	Yes	Yes	1	7	8
186	R:R:G389	R:R:W358	5.63	No	Yes	0	8	8
187	R:R:N392	R:R:W358	9.04	No	Yes	0	9	8
188	R:R:L359	R:R:P360	3.28	Yes	No	0	7	9
189	R:R:I363	R:R:L359	7.14	No	Yes	0	7	7
190	R:R:F361	R:R:F362	9.65	No	Yes	1	8	7
191	R:R:L368	R:R:V364	2.98	Yes	No	0	4	6
192	R:R:C371	R:R:C375	3.64	No	No	0	5	4
193	R:R:S373	R:R:S374	3.26	No	No	0	3	5
194	R:R:M377	R:R:P378	6.71	Yes	No	0	4	7
195	R:R:L381	R:R:M377	4.24	No	Yes	0	6	4
196	R:R:G382	R:R:M377	3.49	No	Yes	0	4	4
197	R:R:W387	R:R:Y390	5.79	Yes	Yes	0	8	8
198	R:R:N392	R:R:N396	12.26	No	Yes	0	9	9
199	R:R:V398	R:R:Y402	6.31	No	Yes	5	6	6
200	R:R:V398	W:W:?1	3.99	No	Yes	5	6	0
201	R:R:I399	R:R:Y400	4.84	No	Yes	0	8	9
202	R:R:F411	R:R:Y402	3.09	No	Yes	0	8	6
203	R:R:Y402	W:W:?1	8.63	Yes	Yes	5	6	0
204	R:R:F403	W:W:?1	37.5	No	Yes	0	8	0
205	R:R:F407	R:R:N404	8.46	Yes	No	0	8	9
206	R:R:N404	W:W:?1	6.43	No	Yes	0	9	0
207	R:R:K405	R:R:Q408	4.07	No	No	0	6	9
208	R:R:F407	R:R:F411	4.29	Yes	No	0	8	8
209	R:R:I414	R:R:I415	2.94	No	No	0	7	7
210	R:R:Q36	R:R:V98	2.87	No	No	0	4	6
211	R:R:I157	R:R:L74	2.85	No	Yes	0	8	8
212	R:R:I163	R:R:L159	2.85	No	No	0	5	3
213	R:R:I384	R:R:L380	2.85	No	No	0	4	3
214	R:R:I142	R:R:N146	2.83	No	No	0	6	5
215	R:R:L368	R:R:M377	2.83	Yes	Yes	0	4	4
216	R:R:D140	R:R:I142	2.8	No	No	0	7	6
217	R:R:A203	R:R:F362	2.77	No	Yes	0	8	7
218	R:R:A401	R:R:F407	2.77	No	Yes	0	8	8
219	R:R:L83	R:R:N54	2.75	No	No	0	8	9
220	R:R:A153	R:R:Y73	2.67	No	No	0	7	6
221	R:R:A137	R:R:Y144	2.67	No	No	0	8	8
222	R:R:R181	R:R:T177	2.59	No	No	0	4	5
223	R:R:F48	R:R:L52	2.44	No	No	0	4	4
224	R:R:I218	R:R:Y135	2.42	No	Yes	0	9	9
225	R:R:I218	R:R:Y215	2.42	No	Yes	0	9	9
226	R:R:D110	R:R:R181	2.38	Yes	No	0	7	4
227	R:R:L166	R:R:Y198	2.34	No	No	0	5	5
228	R:R:D192	R:R:Y195	2.3	No	Yes	0	6	8
229	R:R:L46	R:R:W387	2.28	No	Yes	0	7	8
230	R:R:Q97	R:R:W387	2.19	No	Yes	0	7	8
231	R:R:A79	R:R:G76	1.95	No	No	0	9	6
232	R:R:P184	R:R:S182	1.78	No	No	0	1	3
233	R:R:Q408	W:W:?1	1.78	No	Yes	0	9	0
234	R:R:G202	R:R:I167	1.76	No	No	0	5	8
235	R:R:G202	R:R:I206	1.76	No	No	0	5	6
236	R:R:P150	R:R:T149	1.75	No	No	0	5	8
237	R:R:P178	R:R:T177	1.75	No	No	0	5	5
238	R:R:G53	R:R:L52	1.71	No	No	0	9	4
239	R:R:G352	R:R:L356	1.71	No	No	0	6	5
240	R:R:C371	R:R:V367	1.71	No	No	0	5	6
241	R:R:G389	R:R:L388	1.71	No	No	0	8	8
242	R:R:C49	R:R:T45	1.69	No	No	0	5	4
243	R:R:I47	R:R:P91	1.69	No	No	0	7	9
244	R:R:I385	R:R:P360	1.69	No	No	0	6	9
245	R:R:D192	R:R:G194	1.68	No	No	0	6	5
246	R:R:A365	R:R:T200	1.68	No	Yes	0	8	7
247	R:R:A222	R:R:T343	1.68	No	No	0	8	8
248	R:R:L368	R:R:P369	1.64	Yes	No	0	4	7
249	R:R:A94	R:R:I47	1.62	No	No	0	7	7
250	R:R:A60	R:R:I414	1.62	No	No	0	8	7
251	R:R:A401	R:R:I75	1.62	No	No	0	8	8
252	R:R:C128	R:R:M211	1.62	No	No	0	7	9
253	R:R:A221	R:R:I138	1.62	No	No	0	6	9
254	R:R:A114	R:R:M172	1.61	No	No	0	7	6
255	R:R:D183	R:R:P184	1.61	No	No	0	1	1
256	R:R:A338	R:R:M335	1.61	No	No	0	5	4
257	R:R:V51	R:R:V87	1.6	No	No	0	7	6
258	R:R:C49	R:R:L394	1.59	No	No	0	5	7
259	R:R:C375	R:R:L368	1.59	No	Yes	0	4	4
260	R:R:A50	R:R:L394	1.58	No	No	0	8	7
261	R:R:A55	R:R:L83	1.58	No	No	0	5	8
262	R:R:A71	R:R:N69	1.56	No	No	0	8	8
263	R:R:C109	R:R:D110	1.56	Yes	Yes	0	9	7
264	R:R:K191	R:R:T188	1.5	No	No	0	5	5
265	R:R:L41	R:R:V37	1.49	No	No	0	4	5
266	R:R:L115	R:R:V89	1.49	No	No	0	5	8
267	R:R:L99	R:R:V98	1.49	No	No	0	5	6
268	R:R:D192	R:R:S190	1.47	No	No	0	6	6
269	R:R:E64	R:R:S66	1.44	Yes	No	0	7	6
270	R:R:I38	R:R:L42	1.43	No	No	0	3	5
271	R:R:I384	R:R:L388	1.43	No	No	0	4	8
272	R:R:K412	R:R:N409	1.4	No	No	0	6	6
273	R:R:D110	R:R:M172	1.39	Yes	No	0	7	6
274	R:R:D406	R:R:K405	1.38	No	No	0	7	6
275	R:R:R176	R:R:V107	1.31	No	No	0	6	4
276	R:R:F219	R:R:V344	1.31	Yes	No	0	6	8
277	R:R:Q68	R:R:R65	1.17	No	No	0	8	7
278	R:R:R220	R:R:R223	1.07	No	Yes	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.9225	12	1	0
2	R:R:E64	3.7975	4	4	7
3	R:R:L67	4.335	4	4	8
4	R:R:L74	3.555	4	0	8
5	R:R:D82	6.404	5	2	9
6	R:R:W102	6.8525	8	1	9
7	R:R:L104	5.835	4	1	7
8	R:R:C109	3.5525	4	1	9
9	R:R:D110	3.12	4	0	7
10	R:R:H126	9.128	5	3	8
11	R:R:Y135	6.768	5	0	9
12	R:R:R148	11.2675	4	0	8
13	R:R:W161	6.432	5	3	9
14	R:R:Y195	5.02	4	0	8
15	R:R:T200	3.5575	4	1	7
16	R:R:F204	7.405	6	1	8
17	R:R:Y205	6.3575	4	1	7
18	R:R:Y215	4.29	6	0	9
19	R:R:F219	3.5475	4	0	6
20	R:R:R223	8.145	4	6	7
21	R:R:W358	6.47571	7	1	8
22	R:R:L359	4.5875	4	0	7
23	R:R:F362	9.192	5	1	7
24	R:R:L368	2.26	4	0	4
25	R:R:M377	4.3175	4	0	4
26	R:R:W387	5.4125	4	0	8
27	R:R:Y390	7.312	5	1	8
28	R:R:N396	8.8625	4	2	9
29	R:R:Y400	5.135	4	2	9
30	R:R:Y402	5.595	4	5	6
31	R:R:F407	5.85667	6	4	8
32	W:W:?1	9.8125	8	5	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W102	38.9692	5.21	Yes	Yes	1	0	9
2	R:R:L104	R:R:W102	16.7188	10.25	Yes	Yes	1	7	9
3	R:R:L104	R:R:T103	15.3558	2.95	Yes	No	0	7	5
4	L:L:?1	R:R:Y390	21.2401	8.43	Yes	Yes	1	0	8
5	L:L:?1	R:R:C120	29.0143	6.23	Yes	No	0	0	7
6	R:R:C120	R:R:W358	29.1997	5.22	No	Yes	0	7	8
7	R:R:N392	R:R:W358	100	9.04	No	Yes	0	9	8
8	R:R:N392	R:R:N396	98.1755	12.26	No	Yes	0	9	9
9	R:R:D82	R:R:N396	24.6493	8.08	Yes	Yes	2	9	9
10	R:R:D82	R:R:N54	20.4078	6.73	Yes	No	0	9	9
11	R:R:L83	R:R:N54	17.0786	2.75	No	No	0	8	9
12	R:R:L83	R:R:S86	13.7203	4.5	No	No	0	8	8
13	L:L:?1	R:R:F361	28.8871	14.33	Yes	No	1	0	8
14	R:R:F361	R:R:W358	29.1633	7.02	No	Yes	1	8	8
15	L:L:?1	R:R:F362	39.7579	7.17	Yes	Yes	1	0	7
16	R:R:F362	R:R:W358	30.439	6.01	Yes	Yes	1	7	8
17	R:R:L127	R:R:N396	79.1633	6.87	No	Yes	2	8	9
18	R:R:L127	R:R:Y400	82.1618	4.69	No	Yes	2	8	9
19	R:R:I399	R:R:Y400	52.7731	4.84	No	Yes	0	8	9
20	R:R:I349	R:R:I399	48.8115	4.42	No	No	0	7	8
21	R:R:I349	W:W:?1	47.4595	3.82	No	Yes	0	7	0
22	R:R:Y402	W:W:?1	13.3496	8.63	Yes	Yes	5	6	0
23	R:R:N404	W:W:?1	23.4571	6.43	No	Yes	0	9	0
24	R:R:F407	R:R:N404	22.0361	8.46	Yes	No	0	8	9
25	L:L:?1	R:R:V117	30.4899	6.82	Yes	No	0	0	8
26	R:R:S168	R:R:V117	29.2251	3.23	No	No	0	8	8
27	R:R:L118	R:R:S168	15.6538	6.01	No	No	0	6	8
28	R:R:L118	R:R:W161	14.9742	4.56	No	Yes	0	6	9
29	R:R:H126	R:R:W161	11.3324	3.17	Yes	Yes	3	8	9
30	R:R:H126	R:R:I157	22.3632	5.3	Yes	No	3	8	8
31	R:R:I157	R:R:L74	21.6762	2.85	No	Yes	0	8	8
32	R:R:D133	R:R:L74	13.4513	4.07	No	Yes	0	9	8
33	R:R:D133	R:R:R148	12.699	11.91	No	Yes	0	9	8
34	R:R:C109	R:R:W102	18.0853	3.92	Yes	Yes	1	9	9
35	L:L:?1	R:R:C187	18.8304	4.15	Yes	No	1	0	9
36	R:R:C109	R:R:C187	17.5111	5.46	Yes	No	1	9	9
37	R:R:C109	R:R:D110	29.8575	1.56	Yes	Yes	0	9	7
38	R:R:D110	R:R:R181	15.1668	2.38	Yes	No	0	7	4
39	R:R:I169	R:R:S168	15.8247	4.64	No	No	0	6	8
40	R:R:H126	R:R:T160	16.4389	17.8	Yes	No	0	8	8
41	R:R:I124	R:R:W358	29.4505	9.4	No	Yes	0	8	8
42	R:R:I124	R:R:P207	28.302	3.39	No	No	0	8	9
43	R:R:P207	R:R:W125	22.2832	13.51	No	No	0	9	7
44	R:R:T160	R:R:W125	19.5246	3.64	No	No	0	8	7
45	R:R:F204	R:R:F362	10.253	20.36	Yes	Yes	1	8	7
46	R:R:R134	R:R:Y400	33.1286	6.17	No	Yes	2	9	9
47	R:R:R134	R:R:Y215	32.0818	6.17	No	Yes	0	9	9
48	R:R:I218	R:R:Y215	13.8984	2.42	No	Yes	0	9	9
49	R:R:I218	R:R:Y135	12.3828	2.42	No	Yes	0	9	9
50	R:R:I169	R:R:P170	14.4254	5.08	No	No	0	6	8
51	R:R:P170	R:R:P171	12.6263	5.84	No	No	0	8	7
52	R:R:P171	R:R:Y195	10.8199	4.17	No	Yes	0	7	8
53	R:R:F204	R:R:Y205	17.4384	8.25	Yes	Yes	1	8	7
54	R:R:T200	R:R:Y205	14.28	4.99	Yes	Yes	1	7	7
55	R:R:T196	R:R:T200	12.7353	3.14	No	Yes	0	7	7
56	R:R:P369	R:R:T196	10.2711	10.49	No	No	0	7	7
57	R:R:L347	R:R:Y215	13.3568	3.52	No	Yes	0	8	9
58	R:R:F219	R:R:L347	11.8303	3.65	Yes	No	0	6	8
59	R:R:F204	R:R:W358	15.861	3.01	Yes	Yes	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:A93	5.15	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y96	6.9	1	Yes	No	0	6	0	1
L:L:?1	R:R:W102	5.21	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F112	3.98	1	Yes	No	0	6	0	1
L:L:?1	R:R:D116	19.52	1	Yes	No	0	8	0	1
L:L:?1	R:R:V117	6.82	1	Yes	No	0	8	0	1
L:L:?1	R:R:C120	6.23	1	Yes	No	0	7	0	1
L:L:?1	R:R:C187	4.15	1	Yes	No	0	9	0	1
L:L:?1	R:R:F361	14.33	1	Yes	No	0	8	0	1
L:L:?1	R:R:F362	7.17	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N386	7.18	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y390	8.43	1	Yes	Yes	0	8	0	1
R:R:D116	R:R:V89	7.3	1	No	No	8	8	1	2
R:R:V89	R:R:Y390	3.79	1	No	Yes	8	8	2	1
R:R:L90	R:R:Y390	8.21	0	No	Yes	8	8	2	1
R:R:M92	R:R:W102	3.49	1	No	Yes	6	9	2	1
R:R:L104	R:R:M92	4.24	1	Yes	No	7	6	2	2
R:R:F112	R:R:M92	13.68	1	No	No	6	6	1	2
R:R:W102	R:R:Y96	7.72	1	Yes	No	9	6	1	1
R:R:D185	R:R:Y96	9.2	0	No	No	4	6	2	1
R:R:L104	R:R:W102	10.25	1	Yes	Yes	7	9	2	1
R:R:T108	R:R:W102	4.85	1	No	Yes	6	9	2	1
R:R:C109	R:R:W102	3.92	1	Yes	Yes	9	9	2	1
R:R:F112	R:R:W102	5.01	1	No	Yes	6	9	1	1
R:R:C187	R:R:W102	14.37	1	No	Yes	9	9	1	1
R:R:L104	R:R:T108	5.9	1	Yes	No	7	6	2	2
R:R:C109	R:R:C187	5.46	1	Yes	No	9	9	2	1
R:R:D116	R:R:Y390	10.34	1	No	Yes	8	8	1	1
R:R:S168	R:R:V117	3.23	0	No	No	8	8	2	1
R:R:C120	R:R:W358	5.22	0	No	Yes	7	8	1	2
R:R:F204	R:R:W358	3.01	1	Yes	Yes	8	8	2	2
R:R:F204	R:R:F362	20.36	1	Yes	Yes	8	7	2	1
R:R:F361	R:R:W358	7.02	1	No	Yes	8	8	1	2
R:R:F362	R:R:W358	6.01	1	Yes	Yes	7	8	1	2
R:R:F361	R:R:F362	9.65	1	No	Yes	8	7	1	1
R:R:W387	R:R:Y390	5.79	0	Yes	Yes	8	8	2	1
R:R:A203	R:R:F362	2.77	0	No	Yes	8	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:G53	R:R:Y402	4.35	0	No	Yes	9	6	2	1
R:R:K345	W:W:?1	9.44	0	No	Yes	7	0	1	0
R:R:T346	W:W:?1	6.91	0	No	Yes	8	0	1	0
R:R:I349	R:R:I399	4.42	0	No	No	7	8	1	2
R:R:I349	W:W:?1	3.82	0	No	Yes	7	0	1	0
R:R:V398	R:R:Y402	6.31	5	No	Yes	6	6	1	1
R:R:V398	W:W:?1	3.99	5	No	Yes	6	0	1	0
R:R:F411	R:R:Y402	3.09	0	No	Yes	8	6	2	1
R:R:Y402	W:W:?1	8.63	5	Yes	Yes	6	0	1	0
R:R:F403	W:W:?1	37.5	0	No	Yes	8	0	1	0
R:R:F407	R:R:N404	8.46	4	Yes	No	8	9	2	1
R:R:N404	W:W:?1	6.43	0	No	Yes	9	0	1	0
R:R:K405	R:R:Q408	4.07	0	No	No	6	9	2	1
R:R:F407	R:R:F411	4.29	4	Yes	No	8	8	2	2
R:R:Q408	W:W:?1	1.78	0	No	Yes	9	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9MD1_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.95
Number of Linked Nodes	260
Number of Links	278
Number of Hubs	32
Number of Links mediated by Hubs	139
Number of Communities	6
Number of Nodes involved in Communities	45
Number of Links involved in Communities	63

Path Summary
Number Of Nodes in MetaPath	60
Number Of Links MetaPath	59
Number of Shortest Paths	48128
Length Of Smallest Path	3
Average Path Length	12.953
Length of Longest Path	29
Minimum Path Strength	1.475
Average Path Strength	6.13861
Maximum Path Strength	23.47
Minimum Path Correlation	0.7
Average Path Correlation	0.922473
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	48.6146
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.0916
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • cation binding • binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • protein binding • signaling receptor binding • receptor-receptor interaction • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • behavior • multicellular organismal process • exploration behavior • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • adult behavior • regulation of tube diameter • system process • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • cell-cell signaling • gamma-aminobutyric acid signaling pathway • regulation of behavior • serotonin metabolic process • indole-containing compound metabolic process • cellular response to nitrogen compound • response to dopamine • serotonin receptor signaling pathway • cellular response to dopamine • response to monoamine • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to catecholamine • cellular response to monoamine stimulus • response to chemical • cellular response to catecholamine stimulus • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • monoatomic ion transport • serotonin secretion • regulation of monoatomic ion transport • regulation of serotonin secretion • serotonin transport • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • G protein-coupled serotonin receptor binding • G protein-coupled receptor binding • G-protein beta/gamma-subunit complex binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • carbohydrate derivative binding • ribonucleotide binding • metal ion binding • negative regulation of protein transport • establishment of protein localization • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • negative regulation of cellular process • negative regulation of protein localization • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • insulin secretion • organelle envelope • nuclear envelope • nucleus • endomembrane system • cell body • endoplasmic reticulum
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	YLX
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	YLX
Name	Buspirone
Synonyms	Buspironum
Identifier
Formula	C21 H31 N5 O2
Molecular Weight	385.503
SMILES
PubChem	2477
Formal Charge	0
Total Atoms	59
Total Chiral Atoms	0
Total Bonds	62
Total Aromatic Bonds	6


Code	J40
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	J40
Name	[(2R)-1-[oxidanyl-[(2R,3R,5S,6R)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5E,8E)-hexadeca-5,8,11,14-tetraenoate
Synonyms
Identifier
Formula	C39 H68 O16 P2
Molecular Weight	854.895
SMILES
PubChem
Formal Charge	0
Total Atoms	125
Total Chiral Atoms	5
Total Bonds	125
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08908
Sequence	>9MD1_nogp_Chain_R Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E R S L Q N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N K W T L G Q V T C D L F I A L D V L C C T S S I H L C A I A L D R Y W A I T D P I D Y V N K R T P R R A A A L I S L T W L I G F L I S I P P M L G W R T P E D R S D P D A C T I S K D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C E S S C H M P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F Q N A F K K I I W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7E2X	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	PtdIns4P	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2X (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	PtdIns4P		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	PtdIns4P	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	PtdIns4P		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	PtdIns4P	Gi1/β1/γ2	3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	PtdIns4P		3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	8JSP	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-	Gi1/β1/γ2	3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSP (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-		3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8W8B	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-	Gi1/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8B (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8FY8	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P	Gi1/β1/γ1	2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FY8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P		2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	PtdIns4P	Gi1/β1/γ1	2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	PtdIns4P		2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	PtdIns4P	Gi1/β1/γ1	2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	PtdIns4P		2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	PtdIns4P	Gi1/β1/γ1	2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	PtdIns4P		2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gi1/β1/γ1	2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8PJK	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-	Gi1/β1/γ1	2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PJK (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-		2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gi1/β1/γ1	2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8JT6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	PtdIns4P	Gi1/β1/γ2	3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8JT6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	PtdIns4P		3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	9GL2	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gs/β1/γ2	3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9GL2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9DYD	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P	Go/β1/γ2	2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P		2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Go/β1/γ2	2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P	Gi1/β1/γ2	2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P		2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9VJ5	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Gepirone	-	Go/β1/γ2	2.69	2025-11-12	To be published
	9VJ5 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Gepirone	-		2.69	2025-11-12	To be published
	9VJ6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	F-15599	-	Gi3/β1/γ2	2.62	2025-11-12	To be published
	9VJ6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	F-15599	-		2.62	2025-11-12	To be published
	9VJE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Go/β1/γ2	2.47	2025-11-12	To be published
	9VJE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.47	2025-11-12	To be published
	9VJF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gi3/β1/γ2	2.7	2025-11-12	To be published
	9VJF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.7	2025-11-12	To be published
	9VJG	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	8-OH-DPAT	-	chim(NtGi2-Gz)/β1/γ2	2.67	2025-11-12	To be published
	9VJG (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	8-OH-DPAT	-		2.67	2025-11-12	To be published
	9VMY	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	TMU4142	-	Go/β1/γ2	2.86	2025-11-12	To be published
	9VMY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	TMU4142	-		2.86	2025-11-12	To be published
	9VNF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Pindolol	-	Go/β1/γ2	2.74	2025-11-12	To be published
	9VNF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Pindolol	-		2.74	2025-11-12	To be published
	9KVG	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P	Gi1/β1/γ2	2.63	2025-12-03	To be published
	9KVG (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P		2.63	2025-12-03	To be published
	9KVH	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Cinobufotenine	PtdIns4P	Gi1/β1/γ2	2.59	2025-12-03	To be published
	9KVH (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Cinobufotenine	PtdIns4P		2.59	2025-12-03	To be published
	9KVI	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Bufotenin	PtdIns4P	Gi1/β1/γ2	2.54	2025-12-03	To be published
	9KVI (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Bufotenin	PtdIns4P		2.54	2025-12-03	To be published
	9HYI	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	DP81	-	Gi1/β1/γ2	2.3	2026-01-21	To be published
	9HYI (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	DP81	-		2.3	2026-01-21	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9MD1_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.