psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:A93	5.15	Yes	No	0	0	7
2	L:L:?1	R:R:Y96	6.9	Yes	No	1	0	6
3	L:L:?1	R:R:W102	5.21	Yes	Yes	1	0	9
4	L:L:?1	R:R:F112	3.98	Yes	No	1	0	6
5	L:L:?1	R:R:D116	19.52	Yes	No	1	0	8
6	L:L:?1	R:R:V117	6.82	Yes	No	0	0	8
7	L:L:?1	R:R:C120	6.23	Yes	No	0	0	7
8	L:L:?1	R:R:C187	4.15	Yes	No	1	0	9
9	L:L:?1	R:R:F361	14.33	Yes	No	1	0	8
10	L:L:?1	R:R:F362	7.17	Yes	Yes	1	0	7
11	L:L:?1	R:R:N386	7.18	Yes	No	0	0	7
12	L:L:?1	R:R:Y390	8.43	Yes	Yes	1	0	8
13	R:R:I38	R:R:Y35	10.88	No	No	0	3	4
14	R:R:Q36	R:R:V98	2.87	No	No	0	4	6
15	R:R:T39	R:R:V98	3.17	No	No	0	5	6
16	R:R:L41	R:R:S40	3	No	No	0	4	5
17	R:R:L43	R:R:W387	11.39	No	Yes	0	7	8
18	R:R:L46	R:R:S391	3	No	No	0	7	5
19	R:R:I47	R:R:L90	4.28	No	No	0	7	8
20	R:R:A50	R:R:S86	3.42	No	No	0	8	8
21	R:R:S86	R:R:V51	3.23	No	No	0	8	7
22	R:R:C56	R:R:L52	3.17	No	No	0	8	4
23	R:R:G53	R:R:Y402	4.35	No	Yes	0	9	6
24	R:R:D82	R:R:N54	6.73	Yes	No	0	9	9
25	R:R:N54	R:R:P397	11.4	No	No	0	9	9
26	R:R:A79	R:R:V57	3.39	No	No	0	9	9
27	R:R:A401	R:R:V57	3.39	No	No	0	8	9
28	R:R:V58	R:R:V80	3.21	No	No	0	7	7
29	R:R:A60	R:R:F411	4.16	No	No	0	8	8
30	R:R:F407	R:R:I61	6.28	Yes	No	0	8	8
31	R:R:E64	R:R:L67	3.98	Yes	Yes	4	7	8
32	R:R:A410	R:R:E64	3.02	No	Yes	4	8	7
33	R:R:E64	R:R:K413	6.75	Yes	No	0	7	6
34	R:R:L67	R:R:N72	4.12	Yes	No	4	8	9
35	R:R:F407	R:R:L67	6.09	Yes	Yes	4	8	8
36	R:R:A410	R:R:L67	3.15	No	Yes	4	8	8
37	R:R:Q68	R:R:Y73	4.51	No	No	0	8	6
38	R:R:N69	R:R:N72	9.54	No	No	0	8	9
39	R:R:R148	R:R:V70	14.38	Yes	No	0	8	7
40	R:R:F407	R:R:N72	7.25	Yes	No	4	8	9
41	R:R:P150	R:R:Y73	4.17	No	No	0	5	6
42	R:R:D133	R:R:L74	4.07	No	Yes	0	9	8
43	R:R:A153	R:R:L74	3.15	No	Yes	0	7	8
44	R:R:L156	R:R:L74	4.15	No	Yes	0	6	8
45	R:R:I157	R:R:L74	2.85	No	Yes	0	8	8
46	R:R:H126	R:R:S77	11.16	Yes	No	3	8	9
47	R:R:I157	R:R:S77	9.29	No	No	3	8	9
48	R:R:D82	R:R:L78	5.43	Yes	No	2	9	9
49	R:R:L127	R:R:L78	4.15	No	No	2	8	9
50	R:R:L78	R:R:N396	8.24	No	Yes	2	9	9
51	R:R:S122	R:R:T81	4.8	No	No	3	8	9
52	R:R:H126	R:R:T81	8.21	Yes	No	3	8	9
53	R:R:T81	R:R:W161	3.64	No	Yes	3	9	9
54	R:R:D82	R:R:S123	4.42	Yes	No	0	9	9
55	R:R:D82	R:R:S393	7.36	Yes	No	0	9	9
56	R:R:D82	R:R:N396	8.08	Yes	Yes	2	9	9
57	R:R:L83	R:R:S86	4.5	No	No	0	8	8
58	R:R:M84	R:R:W161	3.49	No	Yes	0	7	9
59	R:R:C119	R:R:V85	3.42	No	No	0	7	8
60	R:R:S393	R:R:V85	6.46	No	No	0	9	8
61	R:R:L88	R:R:V87	4.47	No	No	0	6	6
62	R:R:D116	R:R:V89	7.3	No	No	1	8	8
63	R:R:V89	R:R:Y390	3.79	No	Yes	1	8	8
64	R:R:L90	R:R:Y390	8.21	No	Yes	0	8	8
65	R:R:M92	R:R:W102	3.49	No	Yes	1	6	9
66	R:R:L104	R:R:M92	4.24	Yes	No	1	7	6
67	R:R:F112	R:R:M92	13.68	No	No	1	6	6
68	R:R:L95	R:R:L99	4.15	No	No	0	6	5
69	R:R:W102	R:R:Y96	7.72	Yes	No	1	9	6
70	R:R:D185	R:R:Y96	9.2	No	No	0	4	6
71	R:R:A383	R:R:Q97	4.55	No	No	0	6	7
72	R:R:L99	R:R:T103	2.95	No	No	0	5	5
73	R:R:K101	R:R:T103	4.5	No	No	0	5	5
74	R:R:K101	R:R:P184	3.35	No	No	0	5	1
75	R:R:L104	R:R:W102	10.25	Yes	Yes	1	7	9
76	R:R:T108	R:R:W102	4.85	No	Yes	1	6	9
77	R:R:C109	R:R:W102	3.92	Yes	Yes	1	9	9
78	R:R:F112	R:R:W102	5.01	No	Yes	1	6	9
79	R:R:C187	R:R:W102	14.37	No	Yes	1	9	9
80	R:R:L104	R:R:T103	2.95	Yes	No	0	7	5
81	R:R:L104	R:R:T108	5.9	Yes	No	1	7	6
82	R:R:G105	R:R:T108	3.64	No	No	0	7	6
83	R:R:Q106	R:R:R181	7.01	No	No	0	4	4
84	R:R:C109	R:R:I113	3.27	Yes	No	0	9	7
85	R:R:C109	R:R:C187	5.46	Yes	No	1	9	9
86	R:R:D110	R:R:R176	7.15	Yes	No	0	7	6
87	R:R:L111	R:R:L115	6.92	No	No	0	5	5
88	R:R:D116	R:R:Y390	10.34	No	Yes	1	8	8
89	R:R:S168	R:R:V117	3.23	No	No	0	8	8
90	R:R:L118	R:R:W161	4.56	No	Yes	0	6	9
91	R:R:F165	R:R:L118	9.74	No	No	0	5	6
92	R:R:L118	R:R:S168	6.01	No	No	0	6	8
93	R:R:C120	R:R:W358	5.22	No	Yes	0	7	8
94	R:R:G164	R:R:T121	3.64	No	No	0	8	8
95	R:R:A203	R:R:T121	5.03	No	No	0	8	8
96	R:R:S122	R:R:T160	3.2	No	No	0	8	8
97	R:R:S122	R:R:W161	17.3	No	Yes	3	8	9
98	R:R:I124	R:R:P207	3.39	No	No	0	8	9
99	R:R:I124	R:R:W358	9.4	No	Yes	0	8	8
100	R:R:T160	R:R:W125	3.64	No	No	0	8	7
101	R:R:I163	R:R:W125	16.44	No	No	0	5	7
102	R:R:P207	R:R:W125	13.51	No	No	0	9	7
103	R:R:H126	R:R:I157	5.3	Yes	No	3	8	8
104	R:R:H126	R:R:T160	17.8	Yes	No	0	8	8
105	R:R:H126	R:R:W161	3.17	Yes	Yes	3	8	9
106	R:R:L127	R:R:N396	6.87	No	Yes	2	8	9
107	R:R:L127	R:R:Y400	4.69	No	Yes	2	8	9
108	R:R:C128	R:R:L210	4.76	No	No	0	7	7
109	R:R:A129	R:R:L156	3.15	No	No	0	8	6
110	R:R:I130	R:R:R134	7.52	No	No	2	9	9
111	R:R:I130	R:R:Y400	4.84	No	Yes	2	9	9
112	R:R:A131	R:R:Y215	4	No	Yes	0	9	9
113	R:R:L132	R:R:W136	10.25	No	No	0	6	5
114	R:R:L132	R:R:L214	4.15	No	No	0	6	7
115	R:R:D133	R:R:R148	11.91	No	Yes	0	9	8
116	R:R:R134	R:R:Y215	6.17	No	Yes	0	9	9
117	R:R:R134	R:R:Y400	6.17	No	Yes	2	9	9
118	R:R:W136	R:R:Y135	6.75	No	Yes	0	5	9
119	R:R:T139	R:R:Y135	7.49	No	Yes	0	8	9
120	R:R:L214	R:R:Y135	5.86	No	Yes	0	7	9
121	R:R:R217	R:R:Y135	11.32	No	Yes	0	7	9
122	R:R:A137	R:R:I138	3.25	No	No	0	8	9
123	R:R:D140	R:R:P141	3.22	No	No	0	7	8
124	R:R:D140	R:R:D143	7.98	No	No	0	7	6
125	R:R:D143	R:R:K147	4.15	No	No	0	6	5
126	R:R:D143	R:R:R152	10.72	No	No	0	6	7
127	R:R:R148	R:R:Y144	11.32	Yes	No	0	8	8
128	R:R:N146	R:R:V145	2.96	No	No	0	5	6
129	R:R:R148	R:R:R152	7.46	Yes	No	0	8	7
130	R:R:R151	R:R:T149	6.47	No	No	0	6	8
131	R:R:I163	R:R:L159	2.85	No	No	0	5	3
132	R:R:F165	R:R:I169	6.28	No	No	0	5	6
133	R:R:I167	R:R:Y198	3.63	No	No	0	8	5
134	R:R:I169	R:R:S168	4.64	No	No	0	6	8
135	R:R:I169	R:R:P170	5.08	No	No	0	6	8
136	R:R:P170	R:R:P171	5.84	No	No	0	8	7
137	R:R:P171	R:R:Y195	4.17	No	Yes	0	7	8
138	R:R:G174	R:R:W175	4.22	No	No	0	5	6
139	R:R:D180	R:R:P178	3.22	No	No	0	4	5
140	R:R:I189	R:R:Y195	7.25	No	Yes	0	6	8
141	R:R:K191	R:R:P369	3.35	No	No	0	5	7
142	R:R:F370	R:R:H193	18.1	No	No	0	5	4
143	R:R:S199	R:R:Y195	6.36	No	Yes	0	8	8
144	R:R:T196	R:R:T200	3.14	No	Yes	0	7	7
145	R:R:P369	R:R:T196	10.49	No	No	0	7	7
146	R:R:F370	R:R:T196	3.89	No	No	0	5	7
147	R:R:F201	R:R:I197	5.02	No	No	0	5	7
148	R:R:T200	R:R:Y205	4.99	Yes	Yes	1	7	7
149	R:R:L366	R:R:T200	4.42	No	Yes	1	7	7
150	R:R:F201	R:R:Y205	5.16	No	Yes	0	5	7
151	R:R:F204	R:R:Y205	8.25	Yes	Yes	1	8	7
152	R:R:F204	R:R:L208	4.87	Yes	No	1	8	7
153	R:R:F204	R:R:F354	4.29	Yes	No	1	8	9
154	R:R:F204	R:R:W358	3.01	Yes	Yes	1	8	8
155	R:R:F204	R:R:L359	3.65	Yes	Yes	0	8	7
156	R:R:F204	R:R:F362	20.36	Yes	Yes	1	8	7
157	R:R:L366	R:R:Y205	7.03	No	Yes	1	7	7
158	R:R:I206	R:R:P207	3.39	No	No	0	6	9
159	R:R:L208	R:R:L212	4.15	No	No	0	7	6
160	R:R:F354	R:R:L208	3.65	No	No	1	9	7
161	R:R:F354	R:R:M211	4.98	No	No	0	9	9
162	R:R:R217	R:R:V213	3.92	No	No	0	7	5
163	R:R:L347	R:R:Y215	3.52	No	Yes	0	8	9
164	R:R:I350	R:R:Y215	6.04	No	Yes	0	8	9
165	R:R:M351	R:R:Y215	3.59	No	Yes	0	8	9
166	R:R:F219	R:R:R223	5.34	Yes	Yes	0	6	7
167	R:R:F219	R:R:T343	3.89	Yes	No	0	6	8
168	R:R:F219	R:R:L347	3.65	Yes	No	0	6	8
169	R:R:R223	R:R:R227	19.19	Yes	No	5	7	6
170	R:R:E340	R:R:R223	6.98	No	Yes	5	8	7
171	R:R:F224	R:R:R225	5.34	No	No	0	6	7
172	R:R:F224	R:R:K228	3.72	No	No	0	6	5
173	R:R:I226	R:R:R339	5.01	No	No	0	6	7
174	R:R:E340	R:R:R227	12.79	No	No	5	8	6
175	R:R:E330	R:R:R333	20.93	No	No	0	4	4
176	R:R:E330	R:R:K334	8.1	No	No	0	4	5
177	R:R:M335	R:R:R339	4.96	No	No	0	4	7
178	R:R:L337	R:R:R341	13.36	No	No	0	5	6
179	R:R:I349	R:R:K345	2.91	No	No	0	7	7
180	R:R:I349	R:R:I399	4.42	No	No	0	7	8
181	R:R:L395	R:R:T353	2.95	No	No	0	6	7
182	R:R:I399	R:R:T353	6.08	No	No	0	8	7
183	R:R:I355	R:R:L359	4.28	No	Yes	0	7	7
184	R:R:C357	R:R:N392	3.15	No	No	0	8	9
185	R:R:F361	R:R:W358	7.02	No	Yes	1	8	8
186	R:R:F362	R:R:W358	6.01	Yes	Yes	1	7	8
187	R:R:G389	R:R:W358	5.63	No	Yes	0	8	8
188	R:R:N392	R:R:W358	9.04	No	Yes	0	9	8
189	R:R:L359	R:R:P360	3.28	Yes	No	0	7	9
190	R:R:I363	R:R:L359	7.14	No	Yes	0	7	7
191	R:R:F361	R:R:F362	9.65	No	Yes	1	8	7
192	R:R:L368	R:R:V364	2.98	Yes	No	0	4	6
193	R:R:C371	R:R:C375	3.64	No	No	0	5	4
194	R:R:S373	R:R:S374	3.26	No	No	0	3	5
195	R:R:M377	R:R:P378	6.71	Yes	No	0	4	7
196	R:R:L381	R:R:M377	4.24	No	Yes	0	6	4
197	R:R:G382	R:R:M377	3.49	No	Yes	0	4	4
198	R:R:I384	R:R:L380	2.85	No	No	0	4	3
199	R:R:W387	R:R:Y390	5.79	Yes	Yes	0	8	8
200	R:R:N392	R:R:N396	12.26	No	Yes	0	9	9
201	R:R:V398	R:R:Y402	6.31	No	Yes	0	6	6
202	R:R:I399	R:R:Y400	4.84	No	Yes	0	8	9
203	R:R:F411	R:R:Y402	3.09	No	Yes	0	8	6
204	R:R:F407	R:R:N404	8.46	Yes	No	0	8	9
205	R:R:K405	R:R:Q408	4.07	No	No	0	6	9
206	R:R:F407	R:R:F411	4.29	Yes	No	0	8	8
207	R:R:I414	R:R:I415	2.94	No	No	0	7	7
208	R:R:I142	R:R:N146	2.83	No	No	0	6	5
209	R:R:L368	R:R:M377	2.83	Yes	Yes	0	4	4
210	R:R:D140	R:R:I142	2.8	No	No	0	7	6
211	R:R:P397	R:R:Y402	2.78	No	Yes	0	9	6
212	R:R:A203	R:R:F362	2.77	No	Yes	0	8	7
213	R:R:A401	R:R:F407	2.77	No	Yes	0	8	8
214	R:R:L83	R:R:N54	2.75	No	No	0	8	9
215	R:R:A153	R:R:Y73	2.67	No	No	0	7	6
216	R:R:A137	R:R:Y144	2.67	No	No	0	8	8
217	R:R:F403	R:R:V398	2.62	No	No	0	8	6
218	R:R:R181	R:R:T177	2.59	No	No	0	4	5
219	R:R:F48	R:R:L52	2.44	No	No	0	4	4
220	R:R:I218	R:R:Y135	2.42	No	Yes	0	9	9
221	R:R:I218	R:R:Y215	2.42	No	Yes	0	9	9
222	R:R:D110	R:R:R181	2.38	Yes	No	0	7	4
223	R:R:L166	R:R:Y198	2.34	No	No	0	5	5
224	R:R:D192	R:R:Y195	2.3	No	Yes	0	6	8
225	R:R:L46	R:R:W387	2.28	No	Yes	0	7	8
226	R:R:Q97	R:R:W387	2.19	No	Yes	0	7	8
227	R:R:A79	R:R:G76	1.95	No	No	0	9	6
228	R:R:P184	R:R:S182	1.78	No	No	0	1	3
229	R:R:G202	R:R:I167	1.76	No	No	0	5	8
230	R:R:G202	R:R:I206	1.76	No	No	0	5	6
231	R:R:P150	R:R:T149	1.75	No	No	0	5	8
232	R:R:P178	R:R:T177	1.75	No	No	0	5	5
233	R:R:G53	R:R:L52	1.71	No	No	0	9	4
234	R:R:G352	R:R:L356	1.71	No	No	0	6	5
235	R:R:C371	R:R:V367	1.71	No	No	0	5	6
236	R:R:G389	R:R:L388	1.71	No	No	0	8	8
237	R:R:C49	R:R:T45	1.69	No	No	0	5	4
238	R:R:I47	R:R:P91	1.69	No	No	0	7	9
239	R:R:I385	R:R:P360	1.69	No	No	0	6	9
240	R:R:D192	R:R:G194	1.68	No	No	0	6	5
241	R:R:A365	R:R:T200	1.68	No	Yes	0	8	7
242	R:R:A222	R:R:T343	1.68	No	No	0	8	8
243	R:R:L368	R:R:P369	1.64	Yes	No	0	4	7
244	R:R:A94	R:R:I47	1.62	No	No	0	7	7
245	R:R:A60	R:R:I414	1.62	No	No	0	8	7
246	R:R:A401	R:R:I75	1.62	No	No	0	8	8
247	R:R:C128	R:R:M211	1.62	No	No	0	7	9
248	R:R:A221	R:R:I138	1.62	No	No	0	6	9
249	R:R:A114	R:R:M172	1.61	No	No	0	7	6
250	R:R:D183	R:R:P184	1.61	No	No	0	1	1
251	R:R:A338	R:R:M335	1.61	No	No	0	5	4
252	R:R:V51	R:R:V87	1.6	No	No	0	7	6
253	R:R:C49	R:R:L394	1.59	No	No	0	5	7
254	R:R:C375	R:R:L368	1.59	No	Yes	0	4	4
255	R:R:A50	R:R:L394	1.58	No	No	0	8	7
256	R:R:A55	R:R:L83	1.58	No	No	0	5	8
257	R:R:A71	R:R:N69	1.56	No	No	0	8	8
258	R:R:C109	R:R:D110	1.56	Yes	Yes	0	9	7
259	R:R:I350	R:R:T346	1.52	No	No	0	8	8
260	R:R:K191	R:R:T188	1.5	No	No	0	5	5
261	R:R:L41	R:R:V37	1.49	No	No	0	4	5
262	R:R:L115	R:R:V89	1.49	No	No	0	5	8
263	R:R:L99	R:R:V98	1.49	No	No	0	5	6
264	R:R:D192	R:R:S190	1.47	No	No	0	6	6
265	R:R:E64	R:R:S66	1.44	Yes	No	0	7	6
266	R:R:I38	R:R:L42	1.43	No	No	0	3	5
267	R:R:I384	R:R:L388	1.43	No	No	0	4	8
268	R:R:K412	R:R:N409	1.4	No	No	0	6	6
269	R:R:D110	R:R:M172	1.39	Yes	No	0	7	6
270	R:R:D406	R:R:K405	1.38	No	No	0	7	6
271	R:R:D406	R:R:L67	1.36	No	Yes	0	7	8
272	R:R:R176	R:R:V107	1.31	No	No	0	6	4
273	R:R:F219	R:R:V344	1.31	Yes	No	0	6	8
274	R:R:Q68	R:R:R65	1.17	No	No	0	8	7
275	R:R:R220	R:R:R223	1.07	No	Yes	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.9225	12	1	0
2	R:R:E64	3.7975	4	4	7
3	R:R:L67	3.74	5	4	8
4	R:R:L74	3.555	4	0	8
5	R:R:D82	6.404	5	2	9
6	R:R:W102	6.8525	8	1	9
7	R:R:L104	5.835	4	1	7
8	R:R:C109	3.5525	4	1	9
9	R:R:D110	3.12	4	0	7
10	R:R:H126	9.128	5	3	8
11	R:R:Y135	6.768	5	0	9
12	R:R:R148	11.2675	4	0	8
13	R:R:W161	6.432	5	3	9
14	R:R:Y195	5.02	4	0	8
15	R:R:T200	3.5575	4	1	7
16	R:R:F204	7.405	6	1	8
17	R:R:Y205	6.3575	4	1	7
18	R:R:Y215	4.29	6	0	9
19	R:R:F219	3.5475	4	0	6
20	R:R:R223	8.145	4	5	7
21	R:R:W358	6.47571	7	1	8
22	R:R:L359	4.5875	4	0	7
23	R:R:F362	9.192	5	1	7
24	R:R:L368	2.26	4	0	4
25	R:R:M377	4.3175	4	0	4
26	R:R:W387	5.4125	4	0	8
27	R:R:Y390	7.312	5	1	8
28	R:R:N396	8.8625	4	2	9
29	R:R:Y400	5.135	4	2	9
30	R:R:Y402	4.1325	4	0	6
31	R:R:F407	5.85667	6	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W102	39.1559	5.21	Yes	Yes	1	0	9
2	R:R:L104	R:R:W102	16.819	10.25	Yes	Yes	1	7	9
3	R:R:L104	R:R:T103	15.4478	2.95	Yes	No	0	7	5
4	L:L:?1	R:R:Y390	21.5039	8.43	Yes	Yes	1	0	8
5	L:L:?1	R:R:C120	29.0638	6.23	Yes	No	0	0	7
6	R:R:C120	R:R:W358	29.2481	5.22	No	Yes	0	7	8
7	R:R:N392	R:R:W358	100	9.04	No	Yes	0	9	8
8	R:R:N392	R:R:N396	98.1423	12.26	No	Yes	0	9	9
9	R:R:D82	R:R:N396	63.192	8.08	Yes	Yes	2	9	9
10	R:R:D82	R:R:N54	62.2742	6.73	Yes	No	0	9	9
11	R:R:L83	R:R:N54	16.1408	2.75	No	No	0	8	9
12	R:R:L83	R:R:S86	12.9709	4.5	No	No	0	8	8
13	L:L:?1	R:R:F361	28.9421	14.33	Yes	No	1	0	8
14	R:R:F361	R:R:W358	29.2149	7.02	No	Yes	1	8	8
15	L:L:?1	R:R:F362	39.9705	7.17	Yes	Yes	1	0	7
16	R:R:F362	R:R:W358	30.4939	6.01	Yes	Yes	1	7	8
17	R:R:N54	R:R:P397	47.0697	11.4	No	No	0	9	9
18	R:R:P397	R:R:Y402	45.6432	2.78	No	Yes	0	9	6
19	R:R:F411	R:R:Y402	35.4442	3.09	No	Yes	0	8	6
20	R:R:F407	R:R:F411	29.4582	4.29	Yes	No	0	8	8
21	R:R:F407	R:R:L67	12.8824	6.09	Yes	Yes	4	8	8
22	L:L:?1	R:R:V117	30.7446	6.82	Yes	No	0	0	8
23	R:R:S168	R:R:V117	29.4729	3.23	No	No	0	8	8
24	R:R:L118	R:R:S168	15.8386	6.01	No	No	0	6	8
25	R:R:L118	R:R:W161	15.1714	4.56	No	Yes	0	6	9
26	R:R:H126	R:R:W161	11.4928	3.17	Yes	Yes	3	8	9
27	R:R:H126	R:R:I157	22.5986	5.3	Yes	No	3	8	8
28	R:R:I157	R:R:L74	21.9056	2.85	No	Yes	0	8	8
29	R:R:D133	R:R:L74	13.6012	4.07	No	Yes	0	9	8
30	R:R:D133	R:R:R148	12.8345	11.91	No	Yes	0	9	8
31	R:R:L127	R:R:N396	43.8186	6.87	No	Yes	2	8	9
32	R:R:C109	R:R:W102	18.1791	3.92	Yes	Yes	1	9	9
33	L:L:?1	R:R:C187	18.9237	4.15	Yes	No	1	0	9
34	R:R:C109	R:R:C187	17.6041	5.46	Yes	No	1	9	9
35	R:R:C109	R:R:D110	30.0221	1.56	Yes	Yes	0	9	7
36	R:R:D110	R:R:R181	15.2635	2.38	Yes	No	0	7	4
37	R:R:I169	R:R:S168	15.9307	4.64	No	No	0	6	8
38	R:R:H126	R:R:T160	16.5647	17.8	Yes	No	0	8	8
39	R:R:I124	R:R:W358	29.7051	9.4	No	Yes	0	8	8
40	R:R:I124	R:R:P207	28.544	3.39	No	No	0	8	9
41	R:R:P207	R:R:W125	22.4622	13.51	No	No	0	9	7
42	R:R:T160	R:R:W125	19.6756	3.64	No	No	0	8	7
43	R:R:L127	R:R:Y400	47.9875	4.69	No	Yes	2	8	9
44	R:R:F204	R:R:F362	10.4055	20.36	Yes	Yes	1	8	7
45	R:R:R134	R:R:Y400	37.3424	6.17	No	Yes	2	9	9
46	R:R:R134	R:R:Y215	36.1703	6.17	No	Yes	0	9	9
47	R:R:I218	R:R:Y215	15.0571	2.42	No	Yes	0	9	9
48	R:R:I218	R:R:Y135	13.4132	2.42	No	Yes	0	9	9
49	R:R:I169	R:R:P170	14.5337	5.08	No	No	0	6	8
50	R:R:P170	R:R:P171	12.7202	5.84	No	No	0	8	7
51	R:R:P171	R:R:Y195	10.8994	4.17	No	Yes	0	7	8
52	R:R:F204	R:R:Y205	17.6041	8.25	Yes	Yes	1	8	7
53	R:R:T200	R:R:Y205	14.4195	4.99	Yes	Yes	1	7	7
54	R:R:T196	R:R:T200	12.8603	3.14	No	Yes	0	7	7
55	R:R:P369	R:R:T196	10.3723	10.49	No	No	0	7	7
56	R:R:L347	R:R:Y215	14.2388	3.52	No	Yes	0	8	9
57	R:R:F219	R:R:L347	12.5839	3.65	Yes	No	0	6	8
58	R:R:F204	R:R:W358	15.9528	3.01	Yes	Yes	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:A93	5.15	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y96	6.9	1	Yes	No	0	6	0	1
L:L:?1	R:R:W102	5.21	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F112	3.98	1	Yes	No	0	6	0	1
L:L:?1	R:R:D116	19.52	1	Yes	No	0	8	0	1
L:L:?1	R:R:V117	6.82	1	Yes	No	0	8	0	1
L:L:?1	R:R:C120	6.23	1	Yes	No	0	7	0	1
L:L:?1	R:R:C187	4.15	1	Yes	No	0	9	0	1
L:L:?1	R:R:F361	14.33	1	Yes	No	0	8	0	1
L:L:?1	R:R:F362	7.17	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N386	7.18	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y390	8.43	1	Yes	Yes	0	8	0	1
R:R:D116	R:R:V89	7.3	1	No	No	8	8	1	2
R:R:V89	R:R:Y390	3.79	1	No	Yes	8	8	2	1
R:R:L90	R:R:Y390	8.21	0	No	Yes	8	8	2	1
R:R:M92	R:R:W102	3.49	1	No	Yes	6	9	2	1
R:R:L104	R:R:M92	4.24	1	Yes	No	7	6	2	2
R:R:F112	R:R:M92	13.68	1	No	No	6	6	1	2
R:R:W102	R:R:Y96	7.72	1	Yes	No	9	6	1	1
R:R:D185	R:R:Y96	9.2	0	No	No	4	6	2	1
R:R:L104	R:R:W102	10.25	1	Yes	Yes	7	9	2	1
R:R:T108	R:R:W102	4.85	1	No	Yes	6	9	2	1
R:R:C109	R:R:W102	3.92	1	Yes	Yes	9	9	2	1
R:R:F112	R:R:W102	5.01	1	No	Yes	6	9	1	1
R:R:C187	R:R:W102	14.37	1	No	Yes	9	9	1	1
R:R:L104	R:R:T108	5.9	1	Yes	No	7	6	2	2
R:R:C109	R:R:C187	5.46	1	Yes	No	9	9	2	1
R:R:D116	R:R:Y390	10.34	1	No	Yes	8	8	1	1
R:R:S168	R:R:V117	3.23	0	No	No	8	8	2	1
R:R:C120	R:R:W358	5.22	0	No	Yes	7	8	1	2
R:R:F204	R:R:W358	3.01	1	Yes	Yes	8	8	2	2
R:R:F204	R:R:F362	20.36	1	Yes	Yes	8	7	2	1
R:R:F361	R:R:W358	7.02	1	No	Yes	8	8	1	2
R:R:F362	R:R:W358	6.01	1	Yes	Yes	7	8	1	2
R:R:F361	R:R:F362	9.65	1	No	Yes	8	7	1	1
R:R:W387	R:R:Y390	5.79	0	Yes	Yes	8	8	2	1
R:R:A203	R:R:F362	2.77	0	No	Yes	8	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9MD1_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	259
Number of Links	275
Number of Hubs	31
Number of Links mediated by Hubs	133
Number of Communities	5
Number of Nodes involved in Communities	42
Number of Links involved in Communities	60

Path Summary
Number Of Nodes in MetaPath	59
Number Of Links MetaPath	58
Number of Shortest Paths	48130
Length Of Smallest Path	3
Average Path Length	12.7919
Length of Longest Path	28
Minimum Path Strength	1.37
Average Path Strength	6.18454
Maximum Path Strength	15.6833
Minimum Path Correlation	0.7
Average Path Correlation	0.926755
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	50.7313
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.4266
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • G protein-coupled serotonin receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • G protein-coupled serotonin receptor signaling pathway • negative regulation of protein transport
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • G protein-coupled serotonin receptor signaling pathway • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • membrane-bounded organelle • intracellular organelle • organelle envelope • cellular anatomical structure • intracellular anatomical structure • organelle • nuclear envelope • nucleus • intracellular membrane-bounded organelle • endomembrane system • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular organelle • organelle envelope • cellular anatomical structure • intracellular anatomical structure • organelle • nuclear envelope • nucleus • intracellular membrane-bounded organelle • endomembrane system • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • synapse • cell junction • cell body • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • cytoplasm • endoplasmic reticulum • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • cation binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • signaling receptor binding • receptor-receptor interaction • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • behavior • exploration behavior • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • regulation of tube diameter • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • gamma-aminobutyric acid signaling pathway • regulation of behavior • serotonin metabolic process • indole-containing compound metabolic process • serotonin receptor signaling pathway • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • monoatomic ion transport • serotonin secretion • regulation of monoatomic ion transport • regulation of serotonin secretion • serotonin transport • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	YLX
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	YLX
Name	Buspirone
Synonyms	Buspirona
Identifier
Formula	C21 H31 N5 O2
Molecular Weight	385.503
SMILES
PubChem	2477
Formal Charge	0
Total Atoms	59
Total Chiral Atoms	0
Total Bonds	62
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08908
Sequence	>9MD1_nogp_Chain_R Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E R S L Q N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N K W T L G Q V T C D L F I A L D V L C C T S S I H L C A I A L D R Y W A I T D P I D Y V N K R T P R R A A A L I S L T W L I G F L I S I P P M L G W R T P E D R S D P D A C T I S K D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C E S S C H M P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F Q N A F K K I I W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7E2X	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2X (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-	Gi1/β1/γ2	3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-		3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	8W8B	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-	Gi1/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8B (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8JSP	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-	Gi1/β1/γ2	3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSP (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-		3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8FY8	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-	Gi1/β1/γ1	2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FY8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-		2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-	Gi1/β1/γ1	2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-		2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-	Gi1/β1/γ1	2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-		2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-	Gi1/β1/γ1	2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-		2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gi1/β1/γ1	2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8JT6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-	Gi1/β1/γ2	3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8JT6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-		3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8PJK	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-	Gi1/β1/γ1	2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PJK (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-		2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gi1/β1/γ1	2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	9GL2	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gs/β1/γ2	3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9GL2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9DYF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-	Gi1/β1/γ2	2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-		2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-	Go/β1/γ2	2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-		2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Go/β1/γ2	2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9MD1_nogp.zip

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