psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D116	12.69	Yes	No	1	0	8
2	L:L:?1	R:R:V117	9.95	Yes	No	0	0	8
3	L:L:?1	R:R:C120	8.48	Yes	No	1	0	7
4	L:L:?1	R:R:T121	3.94	Yes	Yes	0	0	8
5	L:L:?1	R:R:I189	6.67	Yes	No	0	0	6
6	L:L:?1	R:R:S199	7.02	Yes	No	0	0	8
7	L:L:?1	R:R:T200	3.94	Yes	Yes	1	0	7
8	L:L:?1	R:R:W358	3.8	Yes	Yes	1	0	8
9	L:L:?1	R:R:F361	23.59	Yes	Yes	1	0	8
10	L:L:?1	R:R:F362	10.57	Yes	Yes	1	0	7
11	L:L:?1	R:R:N386	5.5	Yes	No	1	0	7
12	L:L:?1	R:R:Y390	13.31	Yes	Yes	1	0	8
13	R:R:Q36	R:R:V98	4.3	No	Yes	0	4	6
14	R:R:A94	R:R:L43	4.73	No	No	0	7	7
15	R:R:L43	R:R:W387	11.39	No	Yes	0	7	8
16	R:R:I47	R:R:L90	8.56	No	No	0	7	8
17	R:R:F48	R:R:L52	3.65	No	No	0	4	4
18	R:R:A50	R:R:S86	3.42	No	No	0	8	8
19	R:R:G53	R:R:L52	3.42	No	No	0	9	4
20	R:R:G53	R:R:Y402	4.35	No	Yes	0	9	6
21	R:R:D82	R:R:N54	6.73	Yes	No	0	9	9
22	R:R:L83	R:R:N54	4.12	No	No	0	8	9
23	R:R:N54	R:R:P397	6.52	No	No	0	9	9
24	R:R:A401	R:R:V57	5.09	No	No	0	8	9
25	R:R:V57	R:R:Y402	5.05	No	Yes	0	9	6
26	R:R:V58	R:R:V80	4.81	No	No	0	7	7
27	R:R:A60	R:R:F411	4.16	No	No	0	8	8
28	R:R:F407	R:R:I61	5.02	Yes	No	0	8	8
29	R:R:I414	R:R:L63	8.56	No	No	0	7	6
30	R:R:A410	R:R:E64	4.53	No	No	0	8	7
31	R:R:L67	R:R:N72	8.24	Yes	Yes	2	8	9
32	R:R:D406	R:R:L67	4.07	Yes	Yes	2	7	8
33	R:R:F407	R:R:L67	8.53	Yes	Yes	2	8	8
34	R:R:Q68	R:R:Y73	6.76	No	No	0	8	6
35	R:R:N69	R:R:N72	10.9	No	Yes	0	8	9
36	R:R:R148	R:R:V70	13.08	Yes	No	0	8	7
37	R:R:D406	R:R:N72	4.04	Yes	Yes	2	7	9
38	R:R:F407	R:R:N72	7.25	Yes	Yes	2	8	9
39	R:R:P150	R:R:Y73	5.56	No	No	0	5	6
40	R:R:D133	R:R:L74	5.43	No	No	0	9	8
41	R:R:L156	R:R:L74	4.15	No	No	0	6	8
42	R:R:H126	R:R:S77	5.58	Yes	No	1	8	9
43	R:R:I157	R:R:S77	10.84	No	No	1	8	9
44	R:R:D82	R:R:L78	8.14	Yes	Yes	1	9	9
45	R:R:H126	R:R:L78	5.14	Yes	Yes	1	8	9
46	R:R:L127	R:R:L78	4.15	Yes	Yes	1	8	9
47	R:R:L78	R:R:N396	10.98	Yes	Yes	1	9	9
48	R:R:L78	R:R:Y400	3.52	Yes	Yes	1	9	9
49	R:R:S122	R:R:T81	6.4	No	No	1	8	9
50	R:R:H126	R:R:T81	12.32	Yes	No	1	8	9
51	R:R:T81	R:R:W161	8.49	No	Yes	1	9	9
52	R:R:D82	R:R:S123	5.89	Yes	No	0	9	9
53	R:R:D82	R:R:S393	4.42	Yes	No	0	9	9
54	R:R:D82	R:R:N396	8.08	Yes	Yes	1	9	9
55	R:R:M84	R:R:W161	6.98	No	Yes	0	7	9
56	R:R:C119	R:R:V85	3.42	No	No	0	7	8
57	R:R:S393	R:R:V85	4.85	No	No	0	9	8
58	R:R:L115	R:R:L88	6.92	No	No	0	5	6
59	R:R:L90	R:R:Y390	4.69	No	Yes	0	8	8
60	R:R:M92	R:R:W102	3.49	No	Yes	3	6	9
61	R:R:F112	R:R:M92	9.95	No	No	3	6	6
62	R:R:A93	R:R:Y390	5.34	No	Yes	0	7	8
63	R:R:L95	R:R:L99	4.15	No	No	0	6	5
64	R:R:W102	R:R:Y96	7.72	Yes	No	0	9	6
65	R:R:A383	R:R:Q97	4.55	No	No	0	6	7
66	R:R:Q97	R:R:W387	5.48	No	Yes	0	7	8
67	R:R:L99	R:R:T103	4.42	No	No	0	5	5
68	R:R:L104	R:R:W102	11.39	No	Yes	0	7	9
69	R:R:C109	R:R:W102	5.22	No	Yes	3	9	9
70	R:R:F112	R:R:W102	11.02	No	Yes	3	6	9
71	R:R:C187	R:R:W102	9.14	No	Yes	3	9	9
72	R:R:L104	R:R:T108	7.37	No	No	0	7	6
73	R:R:D110	R:R:Q106	5.22	No	No	5	7	4
74	R:R:Q106	R:R:R181	10.51	No	No	5	4	4
75	R:R:C109	R:R:C187	7.28	No	No	3	9	9
76	R:R:D110	R:R:R181	4.76	No	No	5	7	4
77	R:R:L111	R:R:L115	4.15	No	No	0	5	5
78	R:R:I113	R:R:I189	4.42	No	No	0	7	6
79	R:R:D116	R:R:Y390	10.34	No	Yes	1	8	8
80	R:R:S168	R:R:V117	6.46	No	No	0	8	8
81	R:R:L118	R:R:W161	5.69	No	Yes	0	6	9
82	R:R:F165	R:R:L118	10.96	No	No	0	5	6
83	R:R:C120	R:R:W358	5.22	No	Yes	1	7	8
84	R:R:G164	R:R:T121	3.64	No	Yes	0	8	8
85	R:R:I167	R:R:T121	6.08	No	Yes	0	8	8
86	R:R:A203	R:R:T121	5.03	No	Yes	0	8	8
87	R:R:H126	R:R:S122	6.97	Yes	No	1	8	8
88	R:R:S122	R:R:W161	18.53	No	Yes	1	8	9
89	R:R:F354	R:R:I124	3.77	Yes	No	1	9	8
90	R:R:I124	R:R:W358	11.74	No	Yes	1	8	8
91	R:R:C128	R:R:W125	3.92	No	No	0	7	7
92	R:R:I163	R:R:W125	18.79	No	No	0	5	7
93	R:R:P207	R:R:W125	13.51	No	No	0	9	7
94	R:R:H126	R:R:I157	7.95	Yes	No	1	8	8
95	R:R:H126	R:R:T160	12.32	Yes	No	0	8	8
96	R:R:H126	R:R:W161	5.29	Yes	Yes	1	8	9
97	R:R:L127	R:R:M211	4.24	Yes	Yes	1	8	9
98	R:R:F354	R:R:L127	3.65	Yes	Yes	1	9	8
99	R:R:L127	R:R:N396	6.87	Yes	Yes	1	8	9
100	R:R:L127	R:R:Y400	8.21	Yes	Yes	1	8	9
101	R:R:C128	R:R:M211	4.86	No	Yes	0	7	9
102	R:R:I130	R:R:R134	5.01	No	No	1	9	9
103	R:R:I130	R:R:Y400	4.84	No	Yes	1	9	9
104	R:R:A131	R:R:Y215	6.67	No	Yes	0	9	9
105	R:R:L132	R:R:W136	15.94	No	No	0	6	5
106	R:R:L132	R:R:L214	6.92	No	No	0	6	7
107	R:R:D133	R:R:R148	9.53	No	Yes	0	9	8
108	R:R:R134	R:R:Y215	8.23	No	Yes	1	9	9
109	R:R:R134	R:R:Y400	6.17	No	Yes	1	9	9
110	R:R:W136	R:R:Y135	3.86	No	Yes	0	5	9
111	R:R:T139	R:R:Y135	12.48	No	Yes	0	8	9
112	R:R:L214	R:R:Y135	7.03	No	Yes	0	7	9
113	R:R:R217	R:R:Y135	11.32	No	Yes	0	7	9
114	R:R:I218	R:R:Y135	3.63	No	Yes	0	9	9
115	R:R:R152	R:R:W136	5	No	No	0	7	5
116	R:R:D140	R:R:D143	5.32	No	No	0	7	6
117	R:R:D143	R:R:K147	4.15	No	No	0	6	5
118	R:R:D143	R:R:R152	10.72	No	No	0	6	7
119	R:R:R148	R:R:Y144	12.35	Yes	No	0	8	8
120	R:R:I163	R:R:L159	4.28	No	No	0	5	3
121	R:R:L162	R:R:L166	5.54	No	No	0	5	5
122	R:R:I167	R:R:Y198	4.84	No	No	0	8	5
123	R:R:P170	R:R:P171	5.84	No	No	0	8	7
124	R:R:P170	R:R:W175	4.05	No	No	0	8	6
125	R:R:P171	R:R:Y195	16.69	No	Yes	0	7	8
126	R:R:R176	R:R:R181	24.52	No	No	0	6	4
127	R:R:R176	R:R:S190	3.95	No	No	0	6	6
128	R:R:E179	R:R:S182	4.31	No	No	0	3	3
129	R:R:D183	R:R:P184	4.83	No	No	0	1	1
130	R:R:A186	R:R:D183	4.63	No	No	0	4	1
131	R:R:I189	R:R:Y195	6.04	No	Yes	0	6	8
132	R:R:S190	R:R:Y195	6.36	No	Yes	0	6	8
133	R:R:F370	R:R:H193	18.1	No	No	0	5	4
134	R:R:E372	R:R:H193	6.15	No	No	0	3	4
135	R:R:S199	R:R:Y195	15.26	No	Yes	0	8	8
136	R:R:P369	R:R:T196	12.24	No	No	0	7	7
137	R:R:F370	R:R:T196	3.89	No	No	0	5	7
138	R:R:F201	R:R:I197	3.77	No	No	0	5	7
139	R:R:F370	R:R:I197	5.02	No	No	0	5	7
140	R:R:T200	R:R:Y205	3.75	Yes	Yes	1	7	7
141	R:R:F362	R:R:T200	3.89	Yes	Yes	1	7	7
142	R:R:L366	R:R:T200	8.84	No	Yes	1	7	7
143	R:R:F201	R:R:Y205	5.16	No	Yes	0	5	7
144	R:R:F204	R:R:Y205	6.19	Yes	Yes	1	8	7
145	R:R:F204	R:R:L208	10.96	Yes	Yes	1	8	7
146	R:R:F204	R:R:F354	8.57	Yes	Yes	1	8	9
147	R:R:F204	R:R:W358	5.01	Yes	Yes	1	8	8
148	R:R:F204	R:R:L359	6.09	Yes	Yes	0	8	7
149	R:R:F204	R:R:F362	19.29	Yes	Yes	1	8	7
150	R:R:L366	R:R:Y205	7.03	No	Yes	1	7	7
151	R:R:L208	R:R:L212	6.92	Yes	No	0	7	6
152	R:R:F354	R:R:L208	4.87	Yes	Yes	1	9	7
153	R:R:M211	R:R:Y215	3.59	Yes	Yes	1	9	9
154	R:R:M211	R:R:M351	5.78	Yes	No	1	9	8
155	R:R:F354	R:R:M211	8.71	Yes	Yes	1	9	9
156	R:R:R217	R:R:V213	5.23	No	No	0	7	5
157	R:R:I218	R:R:Y215	3.63	No	Yes	0	9	9
158	R:R:L347	R:R:Y215	4.69	No	Yes	0	8	9
159	R:R:I350	R:R:Y215	7.25	No	Yes	0	8	9
160	R:R:M351	R:R:Y215	4.79	No	Yes	1	8	9
161	R:R:F219	R:R:R223	4.28	Yes	No	4	6	7
162	R:R:E340	R:R:F219	4.66	Yes	Yes	4	8	6
163	R:R:F219	R:R:T343	3.89	Yes	Yes	4	6	8
164	R:R:F219	R:R:L347	4.87	Yes	No	0	6	8
165	R:R:R223	R:R:R227	10.66	No	No	0	7	6
166	R:R:E340	R:R:R223	8.14	Yes	No	4	8	7
167	R:R:F224	R:R:R225	7.48	No	No	0	6	7
168	R:R:F224	R:R:K228	4.96	No	No	0	6	5
169	R:R:I226	R:R:R339	6.26	No	No	0	6	7
170	R:R:E326	R:R:K324	14.85	No	No	0	3	1
171	R:R:A329	R:R:R333	4.15	No	No	0	5	4
172	R:R:E330	R:R:R333	8.14	No	No	0	4	4
173	R:R:E330	R:R:K334	8.1	No	No	0	4	5
174	R:R:M335	R:R:R339	16.13	No	No	0	4	7
175	R:R:E340	R:R:T343	4.23	Yes	Yes	4	8	8
176	R:R:I399	R:R:T353	4.56	No	No	0	8	7
177	R:R:F354	R:R:W358	6.01	Yes	Yes	1	9	8
178	R:R:C357	R:R:N392	7.87	No	No	0	8	9
179	R:R:F362	R:R:W358	6.01	Yes	Yes	1	7	8
180	R:R:G389	R:R:W358	7.04	No	Yes	0	8	8
181	R:R:N392	R:R:W358	14.69	No	Yes	0	9	8
182	R:R:I363	R:R:L359	7.14	No	Yes	0	7	7
183	R:R:F361	R:R:F362	12.86	Yes	Yes	1	8	7
184	R:R:A365	R:R:F361	4.16	No	Yes	0	8	8
185	R:R:F361	R:R:N386	6.04	Yes	No	1	8	7
186	R:R:L368	R:R:M377	4.24	No	No	0	4	4
187	R:R:C371	R:R:C375	5.46	No	No	0	5	4
188	R:R:M377	R:R:P378	6.71	No	No	0	4	7
189	R:R:L381	R:R:M377	4.24	No	No	0	6	4
190	R:R:I385	R:R:L381	7.14	Yes	No	0	6	6
191	R:R:W387	R:R:Y390	16.4	Yes	Yes	0	8	8
192	R:R:N392	R:R:N396	10.9	No	Yes	0	9	9
193	R:R:P397	R:R:Y402	4.17	No	Yes	0	9	6
194	R:R:I399	R:R:Y400	4.84	No	Yes	0	8	9
195	R:R:A401	R:R:F407	4.16	No	Yes	0	8	8
196	R:R:F411	R:R:Y402	10.32	No	Yes	0	8	6
197	R:R:D406	R:R:N404	10.77	Yes	No	2	7	9
198	R:R:F407	R:R:N404	13.29	Yes	No	2	8	9
199	R:R:K405	R:R:Q408	9.49	No	No	0	6	9
200	R:R:D406	R:R:F407	5.97	Yes	Yes	2	7	8
201	R:R:F407	R:R:F411	4.29	Yes	No	0	8	8
202	R:R:K412	R:R:N409	5.6	No	No	0	6	6
203	R:R:A79	R:R:V57	3.39	No	No	0	9	9
204	R:R:I169	R:R:P170	3.39	No	No	0	6	8
205	R:R:I206	R:R:P207	3.39	No	No	0	6	9
206	R:R:I385	R:R:P360	3.39	Yes	No	0	6	9
207	R:R:K191	R:R:P369	3.35	No	No	0	5	7
208	R:R:L359	R:R:P360	3.28	Yes	No	0	7	9
209	R:R:C187	R:R:I113	3.27	No	No	0	9	7
210	R:R:S393	R:R:S86	3.26	No	No	0	9	8
211	R:R:V51	R:R:V87	3.21	No	No	0	7	6
212	R:R:V85	R:R:V89	3.21	No	No	0	8	8
213	R:R:R148	R:R:R152	3.2	Yes	No	0	8	7
214	R:R:C56	R:R:L52	3.17	No	No	0	8	4
215	R:R:A50	R:R:L394	3.15	No	No	0	8	7
216	R:R:A410	R:R:L67	3.15	No	Yes	0	8	8
217	R:R:A129	R:R:L156	3.15	No	No	0	8	6
218	R:R:I385	R:R:V364	3.07	Yes	No	0	6	6
219	R:R:I138	R:R:T139	3.04	No	No	0	9	8
220	R:R:I350	R:R:T346	3.04	No	No	0	8	8
221	R:R:K101	R:R:T103	3	No	No	0	5	5
222	R:R:L83	R:R:V87	2.98	No	No	0	8	6
223	R:R:L88	R:R:V87	2.98	No	No	0	6	6
224	R:R:N146	R:R:V145	2.96	No	No	0	5	6
225	R:R:L43	R:R:T39	2.95	No	No	0	7	5
226	R:R:L395	R:R:T353	2.95	No	No	0	6	7
227	R:R:I414	R:R:I415	2.94	No	No	0	7	7
228	R:R:D192	R:R:T177	2.89	No	No	0	6	5
229	R:R:I169	R:R:L173	2.85	No	No	0	6	6
230	R:R:I355	R:R:L208	2.85	No	Yes	0	7	7
231	R:R:E340	R:R:V344	2.85	Yes	No	0	8	8
232	R:R:I355	R:R:L359	2.85	No	Yes	0	7	7
233	R:R:I384	R:R:L388	2.85	No	No	0	4	8
234	R:R:E179	R:R:T177	2.82	No	No	0	3	5
235	R:R:L41	R:R:L42	2.77	No	No	0	4	5
236	R:R:A71	R:R:R148	2.77	No	Yes	0	8	8
237	R:R:L210	R:R:L214	2.77	No	No	0	7	7
238	R:R:E64	R:R:I414	2.73	No	No	0	7	7
239	R:R:K412	R:R:Q408	2.71	No	No	0	6	9
240	R:R:E64	R:R:K413	2.7	No	No	0	7	6
241	R:R:A137	R:R:Y144	2.67	No	No	0	8	8
242	R:R:F403	R:R:V398	2.62	No	No	0	8	6
243	R:R:D180	R:R:Q106	2.61	No	No	0	4	4
244	R:R:R151	R:R:T149	2.59	No	No	0	6	8
245	R:R:F403	R:R:I349	2.51	No	No	0	8	7
246	R:R:F403	R:R:I399	2.51	No	No	0	8	8
247	R:R:T39	R:R:Y35	2.5	No	No	0	5	4
248	R:R:I75	R:R:Y400	2.42	No	Yes	0	8	9
249	R:R:Q68	R:R:R65	2.34	No	No	0	8	7
250	R:R:D192	R:R:Y195	2.3	No	Yes	0	6	8
251	R:R:L46	R:R:W387	2.28	No	Yes	0	7	8
252	R:R:A79	R:R:G76	1.95	No	No	0	9	6
253	R:R:P150	R:R:V70	1.77	No	No	0	5	7
254	R:R:G44	R:R:I47	1.76	No	No	0	4	7
255	R:R:G202	R:R:I167	1.76	No	No	0	5	8
256	R:R:G202	R:R:I206	1.76	No	No	0	5	6
257	R:R:G382	R:R:I385	1.76	No	Yes	0	4	6
258	R:R:P150	R:R:T149	1.75	No	No	0	5	8
259	R:R:P178	R:R:T177	1.75	No	No	0	5	5
260	R:R:C357	R:R:S391	1.72	No	No	0	8	5
261	R:R:C375	R:R:S374	1.72	No	No	0	4	5
262	R:R:A114	R:R:S168	1.71	No	No	0	7	8
263	R:R:C371	R:R:V367	1.71	No	No	0	5	6
264	R:R:A79	R:R:V58	1.7	No	No	0	9	7
265	R:R:A153	R:R:V70	1.7	No	No	0	7	7
266	R:R:C49	R:R:T45	1.69	No	No	0	5	4
267	R:R:A221	R:R:T139	1.68	No	No	0	6	8
268	R:R:A186	R:R:T188	1.68	No	No	0	4	5
269	R:R:D192	R:R:G194	1.68	No	No	0	6	5
270	R:R:A222	R:R:T343	1.68	No	Yes	0	8	8
271	R:R:L90	R:R:P91	1.64	No	No	0	8	9
272	R:R:S373	R:R:S374	1.63	No	No	0	3	5
273	R:R:S40	R:R:V98	1.62	No	Yes	0	5	6
274	R:R:A336	R:R:I226	1.62	No	No	0	5	6
275	R:R:A114	R:R:M172	1.61	No	No	0	7	6
276	R:R:D140	R:R:P141	1.61	No	No	0	7	8
277	R:R:D185	R:R:P184	1.61	No	No	0	4	1
278	R:R:T39	R:R:V98	1.59	No	Yes	0	5	6
279	R:R:C49	R:R:L394	1.59	No	No	0	5	7
280	R:R:A55	R:R:L83	1.58	No	No	0	5	8
281	R:R:I363	R:R:V367	1.54	No	No	0	7	6
282	R:R:I226	R:R:T343	1.52	No	Yes	0	6	8
283	R:R:F219	R:R:G216	1.51	Yes	No	0	6	3
284	R:R:L67	R:R:S66	1.5	Yes	No	0	8	6
285	R:R:K191	R:R:T188	1.5	No	No	0	5	5
286	R:R:G216	R:R:R220	1.5	No	No	0	3	5
287	R:R:K342	R:R:T346	1.5	No	No	0	8	8
288	R:R:L41	R:R:V37	1.49	No	No	0	4	5
289	R:R:L99	R:R:V98	1.49	No	Yes	0	5	6
290	R:R:I349	R:R:K345	1.45	No	No	0	7	7
291	R:R:I38	R:R:L42	1.43	No	No	0	3	5
292	R:R:I384	R:R:L380	1.43	No	No	0	4	3
293	R:R:I142	R:R:N146	1.42	No	No	0	6	5
294	R:R:G105	R:R:W102	1.41	No	Yes	0	7	9
295	R:R:G174	R:R:W175	1.41	No	No	0	5	6
296	R:R:K334	R:R:L337	1.41	No	No	0	5	5
297	R:R:D140	R:R:I142	1.4	No	No	0	7	6
298	R:R:K147	R:R:N146	1.4	No	No	0	5	5
299	R:R:A338	R:R:R341	1.38	No	No	0	5	6
300	R:R:L356	R:R:L388	1.38	No	No	0	5	8
301	R:R:N325	R:R:N328	1.36	No	No	0	5	3
302	R:R:K324	R:R:R327	1.24	No	No	0	1	3
303	R:R:L166	R:R:Y198	1.17	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.12167	12	1	0
2	R:R:L67	5.098	5	2	8
3	R:R:N72	7.6075	4	2	9
4	R:R:L78	6.386	5	1	9
5	R:R:D82	6.652	5	1	9
6	R:R:V98	2.25	4	0	6
7	R:R:W102	7.05571	7	3	9
8	R:R:T121	4.6725	4	0	8
9	R:R:H126	7.93857	7	1	8
10	R:R:L127	5.424	5	1	8
11	R:R:Y135	7.664	5	0	9
12	R:R:R148	8.186	5	0	8
13	R:R:W161	8.996	5	1	9
14	R:R:Y195	9.33	5	0	8
15	R:R:T200	5.105	4	1	7
16	R:R:F204	9.35167	6	1	8
17	R:R:Y205	5.5325	4	1	7
18	R:R:L208	6.4	4	1	7
19	R:R:M211	5.436	5	1	9
20	R:R:Y215	5.55	7	1	9
21	R:R:F219	3.842	5	4	6
22	R:R:E340	4.97	4	4	8
23	R:R:T343	2.83	4	4	8
24	R:R:F354	5.93	6	1	9
25	R:R:W358	7.44	8	1	8
26	R:R:L359	4.84	4	0	7
27	R:R:F361	11.6625	4	1	8
28	R:R:F362	10.524	5	1	7
29	R:R:I385	3.84	4	0	6
30	R:R:W387	8.8875	4	0	8
31	R:R:Y390	10.016	5	1	8
32	R:R:N396	9.2075	4	1	9
33	R:R:Y400	5	6	1	9
34	R:R:Y402	5.9725	4	0	6
35	R:R:D406	6.2125	4	2	7
36	R:R:F407	6.93	7	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y390	37.925	13.31	Yes	Yes	1	0	8
2	R:R:W387	R:R:Y390	27.863	16.4	Yes	Yes	0	8	8
3	R:R:L43	R:R:W387	20.7635	11.39	No	Yes	0	7	8
4	R:R:L43	R:R:T39	17.2007	2.95	No	No	0	7	5
5	R:R:T39	R:R:V98	13.4682	1.59	No	Yes	0	5	6
6	L:L:?1	R:R:W358	100	3.8	Yes	Yes	1	0	8
7	R:R:N392	R:R:W358	51.478	14.69	No	Yes	0	9	8
8	R:R:N392	R:R:N396	50.3622	10.9	No	Yes	0	9	9
9	R:R:D82	R:R:N396	71.7586	8.08	Yes	Yes	1	9	9
10	R:R:D82	R:R:N54	99.1256	6.73	Yes	No	0	9	9
11	R:R:N54	R:R:P397	78.5579	6.52	No	No	0	9	9
12	R:R:P397	R:R:Y402	75.9282	4.17	No	Yes	0	9	6
13	R:R:G53	R:R:Y402	11.8434	4.35	No	Yes	0	9	6
14	R:R:D82	R:R:S393	26.3622	4.42	Yes	No	0	9	9
15	R:R:S393	R:R:S86	14.7732	3.26	No	No	0	9	8
16	R:R:A50	R:R:S86	11.8434	3.42	No	No	0	8	8
17	R:R:L83	R:R:N54	20.5938	4.12	No	No	0	8	9
18	R:R:V57	R:R:Y402	17.1289	5.05	No	Yes	0	9	6
19	R:R:A79	R:R:V57	11.8434	3.39	No	No	0	9	9
20	R:R:F411	R:R:Y402	45.5791	10.32	No	Yes	0	8	6
21	R:R:F407	R:R:F411	40.0196	4.29	Yes	No	0	8	8
22	R:R:F407	R:R:L67	23.3279	8.53	Yes	Yes	2	8	8
23	R:R:A410	R:R:L67	17.7292	3.15	No	Yes	0	8	8
24	R:R:A410	R:R:E64	14.8059	4.53	No	No	0	8	7
25	R:R:F354	R:R:W358	55.9152	6.01	Yes	Yes	1	9	8
26	R:R:F354	R:R:M211	56.0653	8.71	Yes	Yes	1	9	9
27	R:R:M211	R:R:Y215	92.8352	3.59	Yes	Yes	1	9	9
28	R:R:I218	R:R:Y215	81.155	3.63	No	Yes	0	9	9
29	R:R:I218	R:R:Y135	79.1256	3.63	No	Yes	0	9	9
30	R:R:W136	R:R:Y135	60.0914	3.86	No	Yes	0	5	9
31	R:R:R152	R:R:W136	56.0914	5	No	No	0	7	5
32	R:R:R148	R:R:R152	38.3099	3.2	Yes	No	0	8	7
33	R:R:R148	R:R:V70	19.5693	13.08	Yes	No	0	8	7
34	R:R:P150	R:R:V70	14.7537	1.77	No	No	0	5	7
35	R:R:F354	R:R:L127	42.8059	3.65	Yes	Yes	1	9	8
36	R:R:L127	R:R:L78	45.0832	4.15	Yes	Yes	1	8	9
37	R:R:H126	R:R:L78	26.9755	5.14	Yes	Yes	1	8	9
38	R:R:L127	R:R:Y400	10.7602	8.21	Yes	Yes	1	8	9
39	R:R:H126	R:R:W161	10.7863	5.29	Yes	Yes	1	8	9
40	R:R:L83	R:R:V87	14.7732	2.98	No	No	0	8	6
41	L:L:?1	R:R:I189	49.044	6.67	Yes	No	0	0	6
42	R:R:I113	R:R:I189	17.7423	4.42	No	No	0	7	6
43	R:R:C187	R:R:I113	16.1436	3.27	No	No	0	9	7
44	R:R:C187	R:R:W102	12.6003	9.14	No	Yes	3	9	9
45	R:R:I189	R:R:Y195	32.5416	6.04	No	Yes	0	6	8
46	R:R:S190	R:R:Y195	20.7047	6.36	No	Yes	0	6	8
47	R:R:R176	R:R:S190	17.2855	3.95	No	No	0	6	6
48	R:R:R176	R:R:R181	13.8532	24.52	No	No	0	6	4
49	L:L:?1	R:R:S199	32.9527	7.02	Yes	No	0	0	8
50	R:R:S199	R:R:Y195	31.4323	15.26	No	Yes	0	8	8
51	L:L:?1	R:R:T121	16	3.94	Yes	Yes	0	0	8
52	R:R:I167	R:R:T121	10.5383	6.08	No	Yes	0	8	8
53	R:R:C128	R:R:M211	11.3083	4.86	No	Yes	0	7	9
54	R:R:R134	R:R:Y400	25.4486	6.17	No	Yes	1	9	9
55	R:R:R134	R:R:Y215	25.7945	8.23	No	Yes	1	9	9
56	R:R:D143	R:R:R152	17.1615	10.72	No	No	0	6	7
57	R:R:P171	R:R:Y195	20.7047	16.69	No	Yes	0	7	8
58	R:R:P170	R:R:P171	17.2855	5.84	No	No	0	8	7
59	R:R:D192	R:R:Y195	20.7047	2.3	No	Yes	0	6	8
60	R:R:D192	R:R:T177	13.8532	2.89	No	No	0	6	5
61	L:L:?1	R:R:T200	10.6754	3.94	Yes	Yes	1	0	7
62	R:R:F201	R:R:Y205	30.1794	5.16	No	Yes	0	5	7
63	R:R:F201	R:R:I197	27.9282	3.77	No	No	0	5	7
64	R:R:F370	R:R:I197	25.6639	5.02	No	No	0	5	7
65	R:R:F370	R:R:T196	18.7928	3.89	No	No	0	5	7
66	R:R:P369	R:R:T196	16.4763	12.24	No	No	0	7	7
67	R:R:K191	R:R:P369	14.1468	3.35	No	No	0	5	7
68	R:R:K191	R:R:T188	11.8042	1.5	No	No	0	5	5
69	R:R:F204	R:R:W358	22.5905	5.01	Yes	Yes	1	8	8
70	L:L:?1	R:R:F362	11.9021	10.57	Yes	Yes	1	0	7
71	R:R:F204	R:R:F362	14.4992	19.29	Yes	Yes	1	8	7
72	R:R:F204	R:R:L359	44.0718	6.09	Yes	Yes	0	8	7
73	R:R:L347	R:R:Y215	33.279	4.69	No	Yes	0	8	9
74	R:R:F219	R:R:L347	30.9625	4.87	Yes	No	0	6	8
75	R:R:F219	R:R:T343	14.4144	3.89	Yes	Yes	4	6	8
76	R:R:I399	R:R:Y400	12.4633	4.84	No	Yes	0	8	9
77	R:R:I363	R:R:L359	17.5726	7.14	No	Yes	0	7	7
78	R:R:L359	R:R:P360	23.3279	3.28	Yes	No	0	7	9
79	R:R:I385	R:R:P360	20.4568	3.39	Yes	No	0	6	9
80	R:R:I385	R:R:L381	11.7651	7.14	Yes	No	0	6	6
81	R:R:I363	R:R:V367	14.6754	1.54	No	No	0	7	6
82	R:R:C371	R:R:V367	11.7651	1.71	No	No	0	5	6
83	R:R:F204	R:R:Y205	26.1729	6.19	Yes	Yes	1	8	7
84	R:R:F204	R:R:F354	39.9021	8.57	Yes	Yes	1	8	9
85	R:R:D82	R:R:L78	54.2773	8.14	Yes	Yes	1	9	9
86	R:R:L127	R:R:M211	45.8336	4.24	Yes	Yes	1	8	9
87	R:R:L127	R:R:N396	32.8352	6.87	Yes	Yes	1	8	9
88	R:R:L78	R:R:Y400	25.2333	3.52	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D116	12.69	1	Yes	No	0	8	0	1
L:L:?1	R:R:V117	9.95	1	Yes	No	0	8	0	1
L:L:?1	R:R:C120	8.48	1	Yes	No	0	7	0	1
L:L:?1	R:R:T121	3.94	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:I189	6.67	1	Yes	No	0	6	0	1
L:L:?1	R:R:S199	7.02	1	Yes	No	0	8	0	1
L:L:?1	R:R:T200	3.94	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:W358	3.8	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F361	23.59	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F362	10.57	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N386	5.5	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y390	13.31	1	Yes	Yes	0	8	0	1
R:R:L90	R:R:Y390	4.69	0	No	Yes	8	8	2	1
R:R:A93	R:R:Y390	5.34	0	No	Yes	7	8	2	1
R:R:I113	R:R:I189	4.42	0	No	No	7	6	2	1
R:R:D116	R:R:Y390	10.34	1	No	Yes	8	8	1	1
R:R:S168	R:R:V117	6.46	0	No	No	8	8	2	1
R:R:C120	R:R:W358	5.22	1	No	Yes	7	8	1	1
R:R:G164	R:R:T121	3.64	0	No	Yes	8	8	2	1
R:R:I167	R:R:T121	6.08	0	No	Yes	8	8	2	1
R:R:A203	R:R:T121	5.03	0	No	Yes	8	8	2	1
R:R:F354	R:R:I124	3.77	1	Yes	No	9	8	2	2
R:R:I124	R:R:W358	11.74	1	No	Yes	8	8	2	1
R:R:I189	R:R:Y195	6.04	0	No	Yes	6	8	1	2
R:R:S199	R:R:Y195	15.26	0	No	Yes	8	8	1	2
R:R:T200	R:R:Y205	3.75	1	Yes	Yes	7	7	1	2
R:R:F362	R:R:T200	3.89	1	Yes	Yes	7	7	1	1
R:R:L366	R:R:T200	8.84	1	No	Yes	7	7	2	1
R:R:F204	R:R:Y205	6.19	1	Yes	Yes	8	7	2	2
R:R:F204	R:R:F354	8.57	1	Yes	Yes	8	9	2	2
R:R:F204	R:R:W358	5.01	1	Yes	Yes	8	8	2	1
R:R:F204	R:R:F362	19.29	1	Yes	Yes	8	7	2	1
R:R:L366	R:R:Y205	7.03	1	No	Yes	7	7	2	2
R:R:F354	R:R:W358	6.01	1	Yes	Yes	9	8	2	1
R:R:F362	R:R:W358	6.01	1	Yes	Yes	7	8	1	1
R:R:G389	R:R:W358	7.04	0	No	Yes	8	8	2	1
R:R:N392	R:R:W358	14.69	0	No	Yes	9	8	2	1
R:R:F361	R:R:F362	12.86	1	Yes	Yes	8	7	1	1
R:R:A365	R:R:F361	4.16	0	No	Yes	8	8	2	1
R:R:F361	R:R:N386	6.04	1	Yes	No	8	7	1	1
R:R:W387	R:R:Y390	16.4	0	Yes	Yes	8	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8FYE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.42
Number of Linked Nodes	273
Number of Links	303
Number of Hubs	36
Number of Links mediated by Hubs	145
Number of Communities	5
Number of Nodes involved in Communities	48
Number of Links involved in Communities	75

Path Summary
Number Of Nodes in MetaPath	89
Number Of Links MetaPath	88
Number of Shortest Paths	48257
Length Of Smallest Path	3
Average Path Length	11.7237
Length of Longest Path	27
Minimum Path Strength	1.41
Average Path Strength	6.16758
Maximum Path Strength	18.45
Minimum Path Correlation	0.7
Average Path Correlation	0.939318
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	6.25
Average % Of Corr. Nodes	61.4297
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.9416
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • serotonin binding • amine binding • heterocyclic compound binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • signaling receptor binding • receptor-receptor interaction • electron transport chain • metabolic process • generation of precursor metabolites and energy • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • behavior • exploration behavior • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • regulation of tube diameter • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • gamma-aminobutyric acid signaling pathway • regulation of behavior • ammonium ion metabolic process • serotonin metabolic process • indole-containing compound metabolic process • primary amino compound metabolic process • serotonin receptor signaling pathway • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • monoatomic ion transport • serotonin secretion • regulation of monoatomic ion transport • regulation of serotonin secretion • serotonin transport • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • periplasmic space • somatodendritic compartment • dendrite • dendritic tree
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	YGH
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	YGH
Name	4-fluoro-5-methoxy-3-[2-(pyrrolidin-1-yl)ethyl]-1H-indole
Synonyms
Identifier
Formula	C15 H19 F N2 O
Molecular Weight	262.323
SMILES
PubChem	10015574
Formal Charge	0
Total Atoms	38
Total Chiral Atoms	0
Total Bonds	40
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08908
Sequence	>8FYE_nogp_Chain_R Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E R S L Q N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N K W T L G Q V T C D L F I A L D V L C C T S S I W H L C A I A L D R Y W A I T D P I D Y V N K R T P R R A A A L I S L T W L I G F L I S I P P M L G W R T P E D R S D P D A C T I S K D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C E S S C H M P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F Q N A F K K I I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8PKM	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	t7m	Gi1/β1/γ1	2.9	2024-05-29	To be published
	8PKM (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	t7m		2.9	2024-05-29	To be published
	8PJK	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	t7m	Gi1/β1/γ1	2.4	2024-05-29	To be published
	8PJK (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	t7m		2.4	2024-05-29	To be published
	8FYX	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gi1/β1/γ1	2.72	2024-05-15	10.1038/s41586-024-07403-2
	8FYX (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.72	2024-05-15	10.1038/s41586-024-07403-2
	8FYT	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-	Gi1/β1/γ1	2.64	2024-05-15	10.1038/s41586-024-07403-2
	8FYT (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-		2.64	2024-05-15	10.1038/s41586-024-07403-2
	8FYL	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-	Gi1/β1/γ1	2.94	2024-05-15	10.1038/s41586-024-07403-2
	8FYL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-		2.94	2024-05-15	10.1038/s41586-024-07403-2
	8FYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-	Gi1/β1/γ1	2.85	2024-05-15	10.1038/s41586-024-07403-2
	8FYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-		2.85	2024-05-15	10.1038/s41586-024-07403-2
	8FY8	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-	Gi1/β1/γ1	2.79	2024-05-15	10.1038/s41586-024-07403-2
	8FY8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-		2.79	2024-05-15	10.1038/s41586-024-07403-2
	8JT6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-	Gi1/β1/γ2	3	2024-02-28	To be published
	8JT6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-		3	2024-02-28	To be published
	8W8B	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-	Gi1/β1/γ2	3	2023-11-22	10.1038/s41586-023-06775-1
	8W8B (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-		3	2023-11-22	10.1038/s41586-023-06775-1
	8JSP	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-	Gi1/β1/γ2	3.65	2023-11-15	10.1038/s41586-023-06804-z
	8JSP (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-		3.65	2023-11-15	10.1038/s41586-023-06804-z
	7E2Z	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-	Gi1/β1/γ2	3.1	2021-04-14	10.1038/s41586-021-03376-8
	7E2Z (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-		3.1	2021-04-14	10.1038/s41586-021-03376-8
	7E2Y	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-	Gi1/β1/γ2	3	2021-04-14	10.1038/s41586-021-03376-8
	7E2Y (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-		3	2021-04-14	10.1038/s41586-021-03376-8
	7E2X	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-	Gi1/β1/γ2	3	2021-04-14	10.1038/s41586-021-03376-8
	7E2X (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-		3	2021-04-14	10.1038/s41586-021-03376-8

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