psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D116	12.69	Yes	No	1	0	8
2	L:L:?1	R:R:V117	9.95	Yes	No	0	0	8
3	L:L:?1	R:R:C120	8.48	Yes	No	1	0	7
4	L:L:?1	R:R:T121	3.94	Yes	Yes	0	0	8
5	L:L:?1	R:R:I189	6.67	Yes	No	0	0	6
6	L:L:?1	R:R:S199	7.02	Yes	No	0	0	8
7	L:L:?1	R:R:T200	3.94	Yes	Yes	1	0	7
8	L:L:?1	R:R:W358	3.8	Yes	Yes	1	0	8
9	L:L:?1	R:R:F361	23.59	Yes	Yes	1	0	8
10	L:L:?1	R:R:F362	10.57	Yes	Yes	1	0	7
11	L:L:?1	R:R:N386	5.5	Yes	No	1	0	7
12	L:L:?1	R:R:Y390	13.31	Yes	Yes	1	0	8
13	R:R:Q36	R:R:V98	4.3	No	Yes	0	4	6
14	R:R:A94	R:R:L43	4.73	No	No	0	7	7
15	R:R:L43	R:R:W387	11.39	No	Yes	0	7	8
16	R:R:I47	R:R:L90	8.56	No	No	0	7	8
17	R:R:F48	R:R:L52	3.65	No	No	0	4	4
18	R:R:G53	R:R:Y402	4.35	No	Yes	0	9	6
19	R:R:D82	R:R:N54	6.73	Yes	No	0	9	9
20	R:R:L83	R:R:N54	4.12	No	No	0	8	9
21	R:R:N54	R:R:P397	6.52	No	No	0	9	9
22	R:R:A401	R:R:V57	5.09	No	No	0	8	9
23	R:R:V57	R:R:Y402	5.05	No	Yes	0	9	6
24	R:R:V58	R:R:V80	4.81	No	No	0	7	7
25	R:R:A60	R:R:F411	4.16	No	No	0	8	8
26	R:R:F407	R:R:I61	5.02	Yes	No	0	8	8
27	R:R:I414	R:R:L63	8.56	No	No	0	7	6
28	R:R:A410	R:R:E64	4.53	No	No	0	8	7
29	R:R:L67	R:R:N72	8.24	Yes	Yes	2	8	9
30	R:R:D406	R:R:L67	4.07	Yes	Yes	2	7	8
31	R:R:F407	R:R:L67	8.53	Yes	Yes	2	8	8
32	R:R:Q68	R:R:Y73	6.76	No	No	0	8	6
33	R:R:N69	R:R:N72	10.9	No	Yes	0	8	9
34	R:R:R148	R:R:V70	13.08	Yes	No	0	8	7
35	R:R:D406	R:R:N72	4.04	Yes	Yes	2	7	9
36	R:R:F407	R:R:N72	7.25	Yes	Yes	2	8	9
37	R:R:P150	R:R:Y73	5.56	No	No	0	5	6
38	R:R:D133	R:R:L74	5.43	No	No	0	9	8
39	R:R:L156	R:R:L74	4.15	No	No	0	6	8
40	R:R:H126	R:R:S77	5.58	Yes	No	1	8	9
41	R:R:I157	R:R:S77	10.84	No	No	1	8	9
42	R:R:D82	R:R:L78	8.14	Yes	Yes	1	9	9
43	R:R:H126	R:R:L78	5.14	Yes	Yes	1	8	9
44	R:R:L127	R:R:L78	4.15	Yes	Yes	1	8	9
45	R:R:L78	R:R:N396	10.98	Yes	Yes	1	9	9
46	R:R:S122	R:R:T81	6.4	No	No	1	8	9
47	R:R:H126	R:R:T81	12.32	Yes	No	1	8	9
48	R:R:T81	R:R:W161	8.49	No	Yes	1	9	9
49	R:R:D82	R:R:S123	5.89	Yes	No	0	9	9
50	R:R:D82	R:R:S393	4.42	Yes	No	0	9	9
51	R:R:D82	R:R:N396	8.08	Yes	Yes	1	9	9
52	R:R:M84	R:R:W161	6.98	No	Yes	0	7	9
53	R:R:S393	R:R:V85	4.85	No	No	0	9	8
54	R:R:L115	R:R:L88	6.92	No	No	0	5	6
55	R:R:L90	R:R:Y390	4.69	No	Yes	0	8	8
56	R:R:F112	R:R:M92	9.95	No	No	0	6	6
57	R:R:A93	R:R:Y390	5.34	No	Yes	0	7	8
58	R:R:L95	R:R:L99	4.15	No	No	0	6	5
59	R:R:W102	R:R:Y96	7.72	Yes	No	0	9	6
60	R:R:A383	R:R:Q97	4.55	No	No	0	6	7
61	R:R:Q97	R:R:W387	5.48	No	Yes	0	7	8
62	R:R:L99	R:R:T103	4.42	No	No	0	5	5
63	R:R:L104	R:R:W102	11.39	No	Yes	0	7	9
64	R:R:C109	R:R:W102	5.22	No	Yes	4	9	9
65	R:R:F112	R:R:W102	11.02	No	Yes	0	6	9
66	R:R:C187	R:R:W102	9.14	No	Yes	4	9	9
67	R:R:L104	R:R:T108	7.37	No	No	0	7	6
68	R:R:D110	R:R:Q106	5.22	No	No	5	7	4
69	R:R:Q106	R:R:R181	10.51	No	No	5	4	4
70	R:R:C109	R:R:C187	7.28	No	No	4	9	9
71	R:R:D110	R:R:R181	4.76	No	No	5	7	4
72	R:R:L111	R:R:L115	4.15	No	No	0	5	5
73	R:R:I113	R:R:I189	4.42	No	No	0	7	6
74	R:R:D116	R:R:Y390	10.34	No	Yes	1	8	8
75	R:R:S168	R:R:V117	6.46	No	No	0	8	8
76	R:R:L118	R:R:W161	5.69	No	Yes	0	6	9
77	R:R:F165	R:R:L118	10.96	No	No	0	5	6
78	R:R:C120	R:R:W358	5.22	No	Yes	1	7	8
79	R:R:G164	R:R:T121	3.64	No	Yes	0	8	8
80	R:R:I167	R:R:T121	6.08	No	Yes	0	8	8
81	R:R:A203	R:R:T121	5.03	No	Yes	0	8	8
82	R:R:H126	R:R:S122	6.97	Yes	No	1	8	8
83	R:R:S122	R:R:W161	18.53	No	Yes	1	8	9
84	R:R:F354	R:R:I124	3.77	Yes	No	1	9	8
85	R:R:I124	R:R:W358	11.74	No	Yes	1	8	8
86	R:R:C128	R:R:W125	3.92	No	No	0	7	7
87	R:R:I163	R:R:W125	18.79	No	No	0	5	7
88	R:R:P207	R:R:W125	13.51	No	No	0	9	7
89	R:R:H126	R:R:I157	7.95	Yes	No	1	8	8
90	R:R:H126	R:R:T160	12.32	Yes	No	0	8	8
91	R:R:H126	R:R:W161	5.29	Yes	Yes	1	8	9
92	R:R:L127	R:R:M211	4.24	Yes	Yes	1	8	9
93	R:R:F354	R:R:L127	3.65	Yes	Yes	1	9	8
94	R:R:L127	R:R:N396	6.87	Yes	Yes	1	8	9
95	R:R:L127	R:R:Y400	8.21	Yes	Yes	1	8	9
96	R:R:C128	R:R:M211	4.86	No	Yes	0	7	9
97	R:R:I130	R:R:R134	5.01	No	Yes	1	9	9
98	R:R:I130	R:R:Y400	4.84	No	Yes	1	9	9
99	R:R:A131	R:R:Y215	6.67	No	Yes	0	9	9
100	R:R:L132	R:R:W136	15.94	No	No	0	6	5
101	R:R:L132	R:R:L214	6.92	No	No	0	6	7
102	R:R:D133	R:R:R148	9.53	No	Yes	0	9	8
103	R:R:R134	R:R:Y215	8.23	Yes	Yes	0	9	9
104	R:R:R134	R:R:Y400	6.17	Yes	Yes	1	9	9
105	R:R:R134	W:W:?1	4.88	Yes	Yes	0	9	0
106	R:R:W136	R:R:Y135	3.86	No	Yes	0	5	9
107	R:R:T139	R:R:Y135	12.48	No	Yes	0	8	9
108	R:R:L214	R:R:Y135	7.03	No	Yes	0	7	9
109	R:R:R217	R:R:Y135	11.32	No	Yes	0	7	9
110	R:R:I218	R:R:Y135	3.63	No	Yes	0	9	9
111	R:R:R152	R:R:W136	5	No	No	0	7	5
112	R:R:D140	R:R:D143	5.32	No	No	0	7	6
113	R:R:D143	R:R:K147	4.15	No	No	0	6	5
114	R:R:D143	R:R:R152	10.72	No	No	0	6	7
115	R:R:R148	R:R:Y144	12.35	Yes	No	0	8	8
116	R:R:I163	R:R:L159	4.28	No	No	0	5	3
117	R:R:L162	R:R:L166	5.54	No	No	0	5	5
118	R:R:I167	R:R:Y198	4.84	No	No	0	8	5
119	R:R:P170	R:R:P171	5.84	No	No	0	8	7
120	R:R:P170	R:R:W175	4.05	No	No	0	8	6
121	R:R:P171	R:R:Y195	16.69	No	Yes	0	7	8
122	R:R:R176	R:R:R181	24.52	No	No	0	6	4
123	R:R:R176	R:R:S190	3.95	No	No	0	6	6
124	R:R:E179	R:R:S182	4.31	No	No	0	3	3
125	R:R:D183	R:R:P184	4.83	No	No	0	1	1
126	R:R:A186	R:R:D183	4.63	No	No	0	4	1
127	R:R:I189	R:R:Y195	6.04	No	Yes	0	6	8
128	R:R:S190	R:R:Y195	6.36	No	Yes	0	6	8
129	R:R:F370	R:R:H193	18.1	No	No	0	5	4
130	R:R:E372	R:R:H193	6.15	No	No	0	3	4
131	R:R:S199	R:R:Y195	15.26	No	Yes	0	8	8
132	R:R:P369	R:R:T196	12.24	No	No	0	7	7
133	R:R:F370	R:R:T196	3.89	No	No	0	5	7
134	R:R:F201	R:R:I197	3.77	No	No	0	5	7
135	R:R:F370	R:R:I197	5.02	No	No	0	5	7
136	R:R:T200	R:R:Y205	3.75	Yes	Yes	1	7	7
137	R:R:F362	R:R:T200	3.89	Yes	Yes	1	7	7
138	R:R:L366	R:R:T200	8.84	No	Yes	1	7	7
139	R:R:F201	R:R:Y205	5.16	No	Yes	0	5	7
140	R:R:F204	R:R:Y205	6.19	Yes	Yes	1	8	7
141	R:R:F204	R:R:L208	10.96	Yes	Yes	1	8	7
142	R:R:F204	R:R:F354	8.57	Yes	Yes	1	8	9
143	R:R:F204	R:R:W358	5.01	Yes	Yes	1	8	8
144	R:R:F204	R:R:L359	6.09	Yes	Yes	0	8	7
145	R:R:F204	R:R:F362	19.29	Yes	Yes	1	8	7
146	R:R:L366	R:R:Y205	7.03	No	Yes	1	7	7
147	R:R:L208	R:R:L212	6.92	Yes	No	0	7	6
148	R:R:F354	R:R:L208	4.87	Yes	Yes	1	9	7
149	R:R:M211	R:R:M351	5.78	Yes	No	0	9	8
150	R:R:F354	R:R:M211	8.71	Yes	Yes	1	9	9
151	R:R:R217	R:R:V213	5.23	No	No	0	7	5
152	R:R:I218	R:R:Y215	3.63	No	Yes	0	9	9
153	R:R:L347	R:R:Y215	4.69	No	Yes	0	8	9
154	R:R:I350	R:R:Y215	7.25	No	Yes	0	8	9
155	R:R:M351	R:R:Y215	4.79	No	Yes	0	8	9
156	R:R:F219	R:R:R223	4.28	Yes	No	3	6	7
157	R:R:E340	R:R:F219	4.66	Yes	Yes	3	8	6
158	R:R:F219	R:R:T343	3.89	Yes	Yes	3	6	8
159	R:R:F219	R:R:L347	4.87	Yes	No	0	6	8
160	R:R:R223	R:R:R227	10.66	No	No	0	7	6
161	R:R:E340	R:R:R223	8.14	Yes	No	3	8	7
162	R:R:F224	R:R:R225	7.48	No	No	0	6	7
163	R:R:F224	R:R:K228	4.96	No	No	0	6	5
164	R:R:I226	R:R:R339	6.26	No	No	0	6	7
165	R:R:E326	R:R:K324	14.85	No	No	0	3	1
166	R:R:A329	R:R:R333	4.15	No	No	0	5	4
167	R:R:E330	R:R:R333	8.14	No	No	0	4	4
168	R:R:E330	R:R:K334	8.1	No	No	0	4	5
169	R:R:M335	R:R:R339	16.13	No	No	0	4	7
170	R:R:E340	R:R:T343	4.23	Yes	Yes	3	8	8
171	R:R:K345	W:W:?1	13.22	No	Yes	0	7	0
172	R:R:T346	W:W:?1	8.88	No	Yes	0	8	0
173	R:R:I349	W:W:?1	5.73	No	Yes	0	7	0
174	R:R:I399	R:R:T353	4.56	No	No	0	8	7
175	R:R:F354	R:R:W358	6.01	Yes	Yes	1	9	8
176	R:R:C357	R:R:N392	7.87	No	No	0	8	9
177	R:R:F362	R:R:W358	6.01	Yes	Yes	1	7	8
178	R:R:G389	R:R:W358	7.04	No	Yes	0	8	8
179	R:R:N392	R:R:W358	14.69	No	Yes	0	9	8
180	R:R:I363	R:R:L359	7.14	No	Yes	0	7	7
181	R:R:F361	R:R:F362	12.86	Yes	Yes	1	8	7
182	R:R:A365	R:R:F361	4.16	No	Yes	0	8	8
183	R:R:F361	R:R:N386	6.04	Yes	No	1	8	7
184	R:R:L368	R:R:M377	4.24	No	No	0	4	4
185	R:R:C371	R:R:C375	5.46	No	No	0	5	4
186	R:R:M377	R:R:P378	6.71	No	No	0	4	7
187	R:R:L381	R:R:M377	4.24	No	No	0	6	4
188	R:R:I385	R:R:L381	7.14	Yes	No	0	6	6
189	R:R:W387	R:R:Y390	16.4	Yes	Yes	0	8	8
190	R:R:N392	R:R:N396	10.9	No	Yes	0	9	9
191	R:R:P397	R:R:Y402	4.17	No	Yes	0	9	6
192	R:R:V398	W:W:?1	3.99	No	Yes	0	6	0
193	R:R:I399	R:R:Y400	4.84	No	Yes	0	8	9
194	R:R:A401	R:R:F407	4.16	No	Yes	0	8	8
195	R:R:F411	R:R:Y402	10.32	No	Yes	0	8	6
196	R:R:Y402	W:W:?1	6.28	Yes	Yes	0	6	0
197	R:R:F403	W:W:?1	26.09	No	Yes	0	8	0
198	R:R:D406	R:R:N404	10.77	Yes	No	2	7	9
199	R:R:F407	R:R:N404	13.29	Yes	No	2	8	9
200	R:R:N404	W:W:?1	4.6	No	Yes	0	9	0
201	R:R:K405	R:R:Q408	9.49	No	No	0	6	9
202	R:R:D406	R:R:F407	5.97	Yes	Yes	2	7	8
203	R:R:F407	R:R:F411	4.29	Yes	No	0	8	8
204	R:R:K412	R:R:N409	5.6	No	No	0	6	6
205	R:R:Q408	W:W:?1	3.56	No	Yes	0	9	0
206	R:R:A50	R:R:S86	3.42	No	No	0	8	8
207	R:R:G53	R:R:L52	3.42	No	No	0	9	4
208	R:R:C119	R:R:V85	3.42	No	No	0	7	8
209	R:R:A79	R:R:V57	3.39	No	No	0	9	9
210	R:R:I169	R:R:P170	3.39	No	No	0	6	8
211	R:R:I206	R:R:P207	3.39	No	No	0	6	9
212	R:R:I385	R:R:P360	3.39	Yes	No	0	6	9
213	R:R:K191	R:R:P369	3.35	No	No	0	5	7
214	R:R:L359	R:R:P360	3.28	Yes	No	0	7	9
215	R:R:C187	R:R:I113	3.27	No	No	0	9	7
216	R:R:S393	R:R:S86	3.26	No	No	0	9	8
217	R:R:V51	R:R:V87	3.21	No	No	0	7	6
218	R:R:V85	R:R:V89	3.21	No	No	0	8	8
219	R:R:R148	R:R:R152	3.2	Yes	No	0	8	7
220	R:R:C56	R:R:L52	3.17	No	No	0	8	4
221	R:R:A50	R:R:L394	3.15	No	No	0	8	7
222	R:R:A410	R:R:L67	3.15	No	Yes	0	8	8
223	R:R:A129	R:R:L156	3.15	No	No	0	8	6
224	R:R:I385	R:R:V364	3.07	Yes	No	0	6	6
225	R:R:I138	R:R:T139	3.04	No	No	0	9	8
226	R:R:K101	R:R:T103	3	No	No	0	5	5
227	R:R:L83	R:R:V87	2.98	No	No	0	8	6
228	R:R:L88	R:R:V87	2.98	No	No	0	6	6
229	R:R:N146	R:R:V145	2.96	No	No	0	5	6
230	R:R:L43	R:R:T39	2.95	No	No	0	7	5
231	R:R:L395	R:R:T353	2.95	No	No	0	6	7
232	R:R:I414	R:R:I415	2.94	No	No	0	7	7
233	R:R:D192	R:R:T177	2.89	No	No	0	6	5
234	R:R:I169	R:R:L173	2.85	No	No	0	6	6
235	R:R:I355	R:R:L208	2.85	No	Yes	0	7	7
236	R:R:E340	R:R:V344	2.85	Yes	No	0	8	8
237	R:R:I355	R:R:L359	2.85	No	Yes	0	7	7
238	R:R:I384	R:R:L388	2.85	No	No	0	4	8
239	R:R:E179	R:R:T177	2.82	No	No	0	3	5
240	R:R:L41	R:R:L42	2.77	No	No	0	4	5
241	R:R:A71	R:R:R148	2.77	No	Yes	0	8	8
242	R:R:L210	R:R:L214	2.77	No	No	0	7	7
243	R:R:E64	R:R:I414	2.73	No	No	0	7	7
244	R:R:K412	R:R:Q408	2.71	No	No	0	6	9
245	R:R:E64	R:R:K413	2.7	No	No	0	7	6
246	R:R:A137	R:R:Y144	2.67	No	No	0	8	8
247	R:R:D180	R:R:Q106	2.61	No	No	0	4	4
248	R:R:R151	R:R:T149	2.59	No	No	0	6	8
249	R:R:T39	R:R:Y35	2.5	No	No	0	5	4
250	R:R:I75	R:R:Y400	2.42	No	Yes	0	8	9
251	R:R:Q68	R:R:R65	2.34	No	No	0	8	7
252	R:R:D192	R:R:Y195	2.3	No	Yes	0	6	8
253	R:R:L46	R:R:W387	2.28	No	Yes	0	7	8
254	R:R:A79	R:R:G76	1.95	No	No	0	9	6
255	R:R:P150	R:R:V70	1.77	No	No	0	5	7
256	R:R:G44	R:R:I47	1.76	No	No	0	4	7
257	R:R:G202	R:R:I167	1.76	No	No	0	5	8
258	R:R:G202	R:R:I206	1.76	No	No	0	5	6
259	R:R:G382	R:R:I385	1.76	No	Yes	0	4	6
260	R:R:P150	R:R:T149	1.75	No	No	0	5	8
261	R:R:P178	R:R:T177	1.75	No	No	0	5	5
262	R:R:C357	R:R:S391	1.72	No	No	0	8	5
263	R:R:C375	R:R:S374	1.72	No	No	0	4	5
264	R:R:A114	R:R:S168	1.71	No	No	0	7	8
265	R:R:C371	R:R:V367	1.71	No	No	0	5	6
266	R:R:A79	R:R:V58	1.7	No	No	0	9	7
267	R:R:A153	R:R:V70	1.7	No	No	0	7	7
268	R:R:C49	R:R:T45	1.69	No	No	0	5	4
269	R:R:A221	R:R:T139	1.68	No	No	0	6	8
270	R:R:A186	R:R:T188	1.68	No	No	0	4	5
271	R:R:D192	R:R:G194	1.68	No	No	0	6	5
272	R:R:A222	R:R:T343	1.68	No	Yes	0	8	8
273	R:R:L90	R:R:P91	1.64	No	No	0	8	9
274	R:R:S373	R:R:S374	1.63	No	No	0	3	5
275	R:R:S40	R:R:V98	1.62	No	Yes	0	5	6
276	R:R:A336	R:R:I226	1.62	No	No	0	5	6
277	R:R:A114	R:R:M172	1.61	No	No	0	7	6
278	R:R:D140	R:R:P141	1.61	No	No	0	7	8
279	R:R:D185	R:R:P184	1.61	No	No	0	4	1
280	R:R:T39	R:R:V98	1.59	No	Yes	0	5	6
281	R:R:C49	R:R:L394	1.59	No	No	0	5	7
282	R:R:A55	R:R:L83	1.58	No	No	0	5	8
283	R:R:I363	R:R:V367	1.54	No	No	0	7	6
284	R:R:I226	R:R:T343	1.52	No	Yes	0	6	8
285	R:R:F219	R:R:G216	1.51	Yes	No	0	6	3
286	R:R:L67	R:R:S66	1.5	Yes	No	0	8	6
287	R:R:K191	R:R:T188	1.5	No	No	0	5	5
288	R:R:G216	R:R:R220	1.5	No	No	0	3	5
289	R:R:K342	R:R:T346	1.5	No	No	0	8	8
290	R:R:L41	R:R:V37	1.49	No	No	0	4	5
291	R:R:L99	R:R:V98	1.49	No	Yes	0	5	6
292	R:R:I38	R:R:L42	1.43	No	No	0	3	5
293	R:R:I384	R:R:L380	1.43	No	No	0	4	3
294	R:R:I142	R:R:N146	1.42	No	No	0	6	5
295	R:R:G105	R:R:W102	1.41	No	Yes	0	7	9
296	R:R:G174	R:R:W175	1.41	No	No	0	5	6
297	R:R:K334	R:R:L337	1.41	No	No	0	5	5
298	R:R:D140	R:R:I142	1.4	No	No	0	7	6
299	R:R:K147	R:R:N146	1.4	No	No	0	5	5
300	R:R:A338	R:R:R341	1.38	No	No	0	5	6
301	R:R:L356	R:R:L388	1.38	No	No	0	5	8
302	R:R:N325	R:R:N328	1.36	No	No	0	5	3
303	R:R:K324	R:R:R327	1.24	No	No	0	1	3
304	R:R:L166	R:R:Y198	1.17	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.12167	12	1	0
2	R:R:L67	5.098	5	2	8
3	R:R:N72	7.6075	4	2	9
4	R:R:L78	7.1025	4	1	9
5	R:R:D82	6.652	5	1	9
6	R:R:V98	2.25	4	0	6
7	R:R:W102	7.65	6	4	9
8	R:R:T121	4.6725	4	0	8
9	R:R:H126	7.93857	7	1	8
10	R:R:L127	5.424	5	1	8
11	R:R:R134	6.0725	4	1	9
12	R:R:Y135	7.664	5	0	9
13	R:R:R148	8.186	5	0	8
14	R:R:W161	8.996	5	1	9
15	R:R:Y195	9.33	5	0	8
16	R:R:T200	5.105	4	1	7
17	R:R:F204	9.35167	6	1	8
18	R:R:Y205	5.5325	4	1	7
19	R:R:L208	6.4	4	1	7
20	R:R:M211	5.8975	4	1	9
21	R:R:Y215	5.87667	6	0	9
22	R:R:F219	3.842	5	3	6
23	R:R:E340	4.97	4	3	8
24	R:R:T343	2.83	4	3	8
25	R:R:F354	5.93	6	1	9
26	R:R:W358	7.44	8	1	8
27	R:R:L359	4.84	4	0	7
28	R:R:F361	11.6625	4	1	8
29	R:R:F362	10.524	5	1	7
30	R:R:I385	3.84	4	0	6
31	R:R:W387	8.8875	4	0	8
32	R:R:Y390	10.016	5	1	8
33	R:R:N396	9.2075	4	1	9
34	R:R:Y400	5.296	5	1	9
35	R:R:Y402	6.034	5	0	6
36	R:R:D406	6.2125	4	2	7
37	R:R:F407	6.93	7	2	8
38	W:W:?1	8.58111	9	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y390	35.9626	13.31	Yes	Yes	1	0	8
2	R:R:W387	R:R:Y390	26.3644	16.4	Yes	Yes	0	8	8
3	R:R:L43	R:R:W387	19.6242	11.39	No	Yes	0	7	8
4	R:R:L43	R:R:T39	16.2485	2.95	No	No	0	7	5
5	R:R:T39	R:R:V98	12.7152	1.59	No	Yes	0	5	6
6	L:L:?1	R:R:W358	100	3.8	Yes	Yes	1	0	8
7	R:R:F354	R:R:W358	70.7944	6.01	Yes	Yes	1	9	8
8	R:R:F354	R:R:L127	60.5491	3.65	Yes	Yes	1	9	8
9	R:R:L127	R:R:Y400	62.1526	8.21	Yes	Yes	1	8	9
10	R:R:R134	R:R:Y400	58.3493	6.17	Yes	Yes	1	9	9
11	R:R:R134	W:W:?1	64.8644	4.88	Yes	Yes	0	9	0
12	R:R:Y402	W:W:?1	20.8901	6.28	Yes	Yes	0	6	0
13	R:R:N392	R:R:W358	31.6248	14.69	No	Yes	0	9	8
14	R:R:N392	R:R:N396	31.8611	10.9	No	Yes	0	9	9
15	R:R:D82	R:R:N396	34.9781	8.08	Yes	Yes	1	9	9
16	R:R:D82	R:R:N54	24.5246	6.73	Yes	No	0	9	9
17	R:R:N54	R:R:P397	17.188	6.52	No	No	0	9	9
18	R:R:P397	R:R:Y402	16.3328	4.17	No	Yes	0	9	6
19	R:R:L83	R:R:N54	13.9361	4.12	No	No	0	8	9
20	R:R:V57	R:R:Y402	12.2989	5.05	No	Yes	0	9	6
21	R:R:N404	W:W:?1	34.1172	4.6	No	Yes	0	9	0
22	R:R:F407	R:R:N404	17.6494	13.29	Yes	No	2	8	9
23	R:R:D406	R:R:N404	15.112	10.77	Yes	No	2	7	9
24	R:R:D406	R:R:L67	10.9317	4.07	Yes	Yes	2	7	8
25	R:R:A410	R:R:L67	18.1895	3.15	No	Yes	0	8	8
26	R:R:A410	R:R:E64	15.1851	4.53	No	No	0	8	7
27	R:R:F407	R:R:L67	13.1372	8.53	Yes	Yes	2	8	8
28	R:R:F354	R:R:M211	46.0335	8.71	Yes	Yes	1	9	9
29	R:R:M211	R:R:M351	58.248	5.78	Yes	No	0	9	8
30	R:R:M351	R:R:Y215	57.7079	4.79	No	Yes	0	8	9
31	R:R:I218	R:R:Y215	61.8656	3.63	No	Yes	0	9	9
32	R:R:I218	R:R:Y135	60.3409	3.63	No	Yes	0	9	9
33	R:R:W136	R:R:Y135	45.9548	3.86	No	Yes	0	5	9
34	R:R:R152	R:R:W136	42.956	5	No	No	0	7	5
35	R:R:R148	R:R:R152	29.4306	3.2	Yes	No	0	8	7
36	R:R:R148	R:R:V70	15.0726	13.08	Yes	No	0	8	7
37	R:R:P150	R:R:V70	11.3705	1.77	No	No	0	5	7
38	R:R:L127	R:R:L78	30.4771	4.15	Yes	Yes	1	8	9
39	R:R:H126	R:R:L78	24.6596	5.14	Yes	Yes	1	8	9
40	R:R:D82	R:R:S393	25.8692	4.42	Yes	No	0	9	9
41	R:R:L83	R:R:V87	10.009	2.98	No	No	0	8	6
42	L:L:?1	R:R:I189	46.99	6.67	Yes	No	0	0	6
43	R:R:I113	R:R:I189	16.8617	4.42	No	No	0	7	6
44	R:R:C187	R:R:I113	15.337	3.27	No	No	0	9	7
45	R:R:C187	R:R:W102	11.9669	9.14	No	Yes	4	9	9
46	R:R:I189	R:R:Y195	31.0397	6.04	No	Yes	0	6	8
47	R:R:S190	R:R:Y195	19.7423	6.36	No	Yes	0	6	8
48	R:R:R176	R:R:S190	16.4791	3.95	No	No	0	6	6
49	R:R:R176	R:R:R181	13.2047	24.52	No	No	0	6	4
50	L:L:?1	R:R:S199	31.563	7.02	Yes	No	0	0	8
51	R:R:S199	R:R:Y195	30.0945	15.26	No	Yes	0	8	8
52	L:L:?1	R:R:T121	15.067	3.94	Yes	Yes	0	0	8
53	R:R:C128	R:R:M211	11.5281	4.86	No	Yes	0	7	9
54	R:R:D143	R:R:R152	13.2216	10.72	No	No	0	6	7
55	R:R:P171	R:R:Y195	19.7423	16.69	No	Yes	0	7	8
56	R:R:P170	R:R:P171	16.4791	5.84	No	No	0	8	7
57	R:R:D192	R:R:Y195	19.7423	2.3	No	Yes	0	6	8
58	R:R:D192	R:R:T177	13.2047	2.89	No	No	0	6	5
59	R:R:F201	R:R:Y205	23.1743	5.16	No	Yes	0	5	7
60	R:R:F201	R:R:I197	21.4527	3.77	No	No	0	5	7
61	R:R:F370	R:R:I197	19.7198	5.02	No	No	0	5	7
62	R:R:F370	R:R:T196	14.4537	3.89	No	No	0	5	7
63	R:R:P369	R:R:T196	12.6758	12.24	No	No	0	7	7
64	R:R:K191	R:R:P369	10.8867	3.35	No	No	0	5	7
65	R:R:F204	R:R:W358	14.7744	5.01	Yes	Yes	1	8	8
66	L:L:?1	R:R:F362	10.2622	10.57	Yes	Yes	1	0	7
67	R:R:F204	R:R:F362	13.4466	19.29	Yes	Yes	1	8	7
68	R:R:F204	R:R:L359	34.708	6.09	Yes	Yes	0	8	7
69	R:R:L347	R:R:Y215	25.5598	4.69	No	Yes	0	8	9
70	R:R:F219	R:R:L347	23.7876	4.87	Yes	No	0	6	8
71	R:R:F219	R:R:T343	11.0892	3.89	Yes	Yes	3	6	8
72	R:R:I363	R:R:L359	13.8348	7.14	No	Yes	0	7	7
73	R:R:L359	R:R:P360	18.3583	3.28	Yes	No	0	7	9
74	R:R:I385	R:R:P360	16.1022	3.39	Yes	No	0	6	9
75	R:R:I363	R:R:V367	11.5562	1.54	No	No	0	7	6
76	R:R:S393	R:R:S86	14.4818	3.26	No	No	0	9	8
77	R:R:A50	R:R:S86	11.6068	3.42	No	No	0	8	8
78	R:R:F204	R:R:Y205	19.5173	6.19	Yes	Yes	1	8	7
79	R:R:F204	R:R:F354	33.4927	8.57	Yes	Yes	1	8	9
80	R:R:R134	R:R:Y215	33.2339	8.23	Yes	Yes	0	9	9
81	R:R:D82	R:R:L78	15.1007	8.14	Yes	Yes	1	9	9
82	R:R:L127	R:R:M211	16.406	4.24	Yes	Yes	1	8	9
83	R:R:L127	R:R:N396	16.0347	6.87	Yes	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D116	12.69	1	Yes	No	0	8	0	1
L:L:?1	R:R:V117	9.95	1	Yes	No	0	8	0	1
L:L:?1	R:R:C120	8.48	1	Yes	No	0	7	0	1
L:L:?1	R:R:T121	3.94	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:I189	6.67	1	Yes	No	0	6	0	1
L:L:?1	R:R:S199	7.02	1	Yes	No	0	8	0	1
L:L:?1	R:R:T200	3.94	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:W358	3.8	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F361	23.59	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F362	10.57	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N386	5.5	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y390	13.31	1	Yes	Yes	0	8	0	1
R:R:L90	R:R:Y390	4.69	0	No	Yes	8	8	2	1
R:R:A93	R:R:Y390	5.34	0	No	Yes	7	8	2	1
R:R:I113	R:R:I189	4.42	0	No	No	7	6	2	1
R:R:D116	R:R:Y390	10.34	1	No	Yes	8	8	1	1
R:R:S168	R:R:V117	6.46	0	No	No	8	8	2	1
R:R:C120	R:R:W358	5.22	1	No	Yes	7	8	1	1
R:R:G164	R:R:T121	3.64	0	No	Yes	8	8	2	1
R:R:I167	R:R:T121	6.08	0	No	Yes	8	8	2	1
R:R:A203	R:R:T121	5.03	0	No	Yes	8	8	2	1
R:R:F354	R:R:I124	3.77	1	Yes	No	9	8	2	2
R:R:I124	R:R:W358	11.74	1	No	Yes	8	8	2	1
R:R:I189	R:R:Y195	6.04	0	No	Yes	6	8	1	2
R:R:S199	R:R:Y195	15.26	0	No	Yes	8	8	1	2
R:R:T200	R:R:Y205	3.75	1	Yes	Yes	7	7	1	2
R:R:F362	R:R:T200	3.89	1	Yes	Yes	7	7	1	1
R:R:L366	R:R:T200	8.84	1	No	Yes	7	7	2	1
R:R:F204	R:R:Y205	6.19	1	Yes	Yes	8	7	2	2
R:R:F204	R:R:F354	8.57	1	Yes	Yes	8	9	2	2
R:R:F204	R:R:W358	5.01	1	Yes	Yes	8	8	2	1
R:R:F204	R:R:F362	19.29	1	Yes	Yes	8	7	2	1
R:R:L366	R:R:Y205	7.03	1	No	Yes	7	7	2	2
R:R:F354	R:R:W358	6.01	1	Yes	Yes	9	8	2	1
R:R:F362	R:R:W358	6.01	1	Yes	Yes	7	8	1	1
R:R:G389	R:R:W358	7.04	0	No	Yes	8	8	2	1
R:R:N392	R:R:W358	14.69	0	No	Yes	9	8	2	1
R:R:F361	R:R:F362	12.86	1	Yes	Yes	8	7	1	1
R:R:A365	R:R:F361	4.16	0	No	Yes	8	8	2	1
R:R:F361	R:R:N386	6.04	1	Yes	No	8	7	1	1
R:R:W387	R:R:Y390	16.4	0	Yes	Yes	8	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:G53	R:R:Y402	4.35	0	No	Yes	9	6	2	1
R:R:V57	R:R:Y402	5.05	0	No	Yes	9	6	2	1
R:R:I130	R:R:R134	5.01	1	No	Yes	9	9	2	1
R:R:I130	R:R:Y400	4.84	1	No	Yes	9	9	2	2
R:R:R134	R:R:Y215	8.23	1	Yes	Yes	9	9	1	2
R:R:R134	R:R:Y400	6.17	1	Yes	Yes	9	9	1	2
R:R:R134	W:W:?1	4.88	1	Yes	Yes	9	0	1	0
R:R:K345	W:W:?1	13.22	0	No	Yes	7	0	1	0
R:R:T346	W:W:?1	8.88	0	No	Yes	8	0	1	0
R:R:I349	W:W:?1	5.73	0	No	Yes	7	0	1	0
R:R:P397	R:R:Y402	4.17	0	No	Yes	9	6	2	1
R:R:V398	W:W:?1	3.99	0	No	Yes	6	0	1	0
R:R:F411	R:R:Y402	10.32	0	No	Yes	8	6	2	1
R:R:Y402	W:W:?1	6.28	0	Yes	Yes	6	0	1	0
R:R:F403	W:W:?1	26.09	0	No	Yes	8	0	1	0
R:R:D406	R:R:N404	10.77	2	Yes	No	7	9	2	1
R:R:F407	R:R:N404	13.29	2	Yes	No	8	9	2	1
R:R:N404	W:W:?1	4.6	2	No	Yes	9	0	1	0
R:R:K405	R:R:Q408	9.49	0	No	No	6	9	2	1
R:R:D406	R:R:F407	5.97	2	Yes	Yes	7	8	2	2
R:R:F407	R:R:F411	4.29	2	Yes	No	8	8	2	2
R:R:Q408	W:W:?1	3.56	0	No	Yes	9	0	1	0
R:R:K412	R:R:Q408	2.71	0	No	No	6	9	2	1
R:R:K342	R:R:T346	1.5	0	No	No	8	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8FYE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.63
Number of Linked Nodes	274
Number of Links	304
Number of Hubs	38
Number of Links mediated by Hubs	152
Number of Communities	5
Number of Nodes involved in Communities	44
Number of Links involved in Communities	67

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	48803
Length Of Smallest Path	3
Average Path Length	11.3836
Length of Longest Path	27
Minimum Path Strength	1.41
Average Path Strength	6.26049
Maximum Path Strength	19.655
Minimum Path Correlation	0.7
Average Path Correlation	0.937503
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.88235
Average % Of Corr. Nodes	59.8617
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.2802
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cation binding • binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • protein binding • signaling receptor binding • receptor-receptor interaction • tetrapyrrole binding • heme binding • electron transfer activity • transition metal ion binding • iron ion binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • behavior • multicellular organismal process • exploration behavior • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • adult behavior • regulation of tube diameter • system process • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • cell-cell signaling • gamma-aminobutyric acid signaling pathway • regulation of behavior • serotonin metabolic process • indole-containing compound metabolic process • cellular response to nitrogen compound • response to dopamine • serotonin receptor signaling pathway • cellular response to dopamine • response to monoamine • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to catecholamine • cellular response to monoamine stimulus • response to chemical • cellular response to catecholamine stimulus • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • monoatomic ion transport • serotonin secretion • regulation of monoatomic ion transport • regulation of serotonin secretion • serotonin transport • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • electron transport chain • generation of precursor metabolites and energy • cell periphery • cellular anatomical structure • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • synapse • cell junction • periplasmic space • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • establishment of protein localization • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • negative regulation of cellular process • negative regulation of protein localization • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	YGH
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	YGH
Name	4-fluoro-5-methoxy-3-[2-(pyrrolidin-1-yl)ethyl]-1H-indole
Synonyms
Identifier
Formula	C15 H19 F N2 O
Molecular Weight	262.323
SMILES
PubChem	10015574
Formal Charge	0
Total Atoms	38
Total Chiral Atoms	0
Total Bonds	40
Total Aromatic Bonds	10


Code	J40
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	J40
Name	[(2R)-1-[oxidanyl-[(2R,3R,5S,6R)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5E,8E)-hexadeca-5,8,11,14-tetraenoate
Synonyms
Identifier
Formula	C39 H68 O16 P2
Molecular Weight	854.895
SMILES
PubChem
Formal Charge	0
Total Atoms	125
Total Chiral Atoms	5
Total Bonds	125
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08908
Sequence	>8FYE_nogp_Chain_R Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E R S L Q N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N K W T L G Q V T C D L F I A L D V L C C T S S I W H L C A I A L D R Y W A I T D P I D Y V N K R T P R R A A A L I S L T W L I G F L I S I P P M L G W R T P E D R S D P D A C T I S K D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C E S S C H M P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F Q N A F K K I I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7E2X	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	PtdIns4P	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2X (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	PtdIns4P		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	PtdIns4P	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	PtdIns4P		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	PtdIns4P	Gi1/β1/γ2	3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	PtdIns4P		3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	8JSP	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-	Gi1/β1/γ2	3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSP (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-		3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8W8B	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-	Gi1/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8B (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8FY8	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P	Gi1/β1/γ1	2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FY8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P		2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	PtdIns4P	Gi1/β1/γ1	2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	PtdIns4P		2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	PtdIns4P	Gi1/β1/γ1	2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	PtdIns4P		2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	PtdIns4P	Gi1/β1/γ1	2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	PtdIns4P		2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gi1/β1/γ1	2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8PJK	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-	Gi1/β1/γ1	2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PJK (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-		2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gi1/β1/γ1	2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8JT6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	PtdIns4P	Gi1/β1/γ2	3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8JT6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	PtdIns4P		3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	9GL2	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gs/β1/γ2	3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9GL2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9DYD	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P	Go/β1/γ2	2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P		2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Go/β1/γ2	2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P	Gi1/β1/γ2	2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P		2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9VJ5	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Gepirone	-	Go/β1/γ2	2.69	2025-11-12	To be published
	9VJ5 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Gepirone	-		2.69	2025-11-12	To be published
	9VJ6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	F-15599	-	Gi3/β1/γ2	2.62	2025-11-12	To be published
	9VJ6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	F-15599	-		2.62	2025-11-12	To be published
	9VJE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Go/β1/γ2	2.47	2025-11-12	To be published
	9VJE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.47	2025-11-12	To be published
	9VJF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gi3/β1/γ2	2.7	2025-11-12	To be published
	9VJF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.7	2025-11-12	To be published
	9VJG	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	8-OH-DPAT	-	chim(NtGi2-Gz)/β1/γ2	2.67	2025-11-12	To be published
	9VJG (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	8-OH-DPAT	-		2.67	2025-11-12	To be published
	9VMY	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	TMU4142	-	Go/β1/γ2	2.86	2025-11-12	To be published
	9VMY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	TMU4142	-		2.86	2025-11-12	To be published
	9VNF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Pindolol	-	Go/β1/γ2	2.74	2025-11-12	To be published
	9VNF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Pindolol	-		2.74	2025-11-12	To be published
	9KVG	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P	Gi1/β1/γ2	2.63	2025-12-03	To be published
	9KVG (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P		2.63	2025-12-03	To be published
	9KVH	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Cinobufotenine	PtdIns4P	Gi1/β1/γ2	2.59	2025-12-03	To be published
	9KVH (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Cinobufotenine	PtdIns4P		2.59	2025-12-03	To be published
	9KVI	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Bufotenin	PtdIns4P	Gi1/β1/γ2	2.54	2025-12-03	To be published
	9KVI (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Bufotenin	PtdIns4P		2.54	2025-12-03	To be published
	9HYI	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	DP81	-	Gi1/β1/γ2	2.3	2026-01-21	To be published
	9HYI (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	DP81	-		2.3	2026-01-21	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8FYE_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.